Dokokin tricor don amfani, contraindications, tasirin sakamako, sake dubawa

Wani wakili na zubar da jini daga rukunin abubuwan asali na fibroic acid.
Shiri: TAFIYA
Aiki mai guba na miyagun ƙwayoyi: fenofibrate
Lullukin ATX: C10AB05
KFG: Magungunan ƙwayar cuta
Lambar yin rijista: LSR-002450/08
Ranar Rajista: 04/03/08
Mai mallaka reg. doc.: dakunan gwaje-gwaje FOURNIER S.A.

Formaddamar da nau'in Tricor, marufin magunguna da abun da ke ciki

Allunan an lullube su da farin fim, tare da rubutu “145” a gefe guda kuma tambarin kamfanin a daya bangaren. Allunan mai rufe fim. fenofibrate (micronized) 145 MG
Waɗanda suka ƙware: sucrose, sodium lauryl sulfate, lactose monohydrate, crospovidone, microcrystalline cellulose, sillofon silicon dioxide, hypromellose, sodium docusate, magnesium stearate.
Harshen Shell: Opadry OY-B-28920 (barasa polyvinyl, titanium dioxide, talc, soya lecithin, xanthan dan gum).
10 inji mai kwakwalwa - blister (1) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (2) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (5) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (9) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (10) - fakitoci na kwali.
Guda 14. - blister (2) - fakitoci na kwali.
Guda 14. - blister (6) - fakitoci na kwali.
Guda 14. - blister (7) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (28) - kwali na kwali (kwace don asibitoci).
10 inji mai kwakwalwa - blister (30) - kwali na kwali (kwace don asibitoci).
Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Magunguna na Farmacological

Wani wakili na zubar da jini daga rukunin abubuwan asali na fibroic acid. Fenofibrate yana da ikon canza abun ciki mai narkewa a cikin jikin mutum ta hanyar kunnawar masu karɓar PPAR- masu karɓa (alpha receptors wanda ke ci gaba da yaduwar peroxisome).
Fenofibrate yana haɓaka ƙwayar plasma lipolysis da kuma excretion na atherogenic lipoproteins tare da babban abun ciki na triglycerides ta kunna masu karɓar PPAR-α, lipoprotein lipo kuma rage haɓakar apoprotein C-III. Sakamakon da aka bayyana a sama yana haifar da raguwa a cikin abubuwan da ke cikin ƙananan lamuran LDL da VLDL, wanda ya haɗa da apoprotein B (apo B), da haɓaka abubuwan da ke cikin ƙananan juzu'in na HDL, wanda ya haɗa da apo A-I da apo A-II. Bugu da ƙari, saboda gyaran ƙetarewar rikice-rikice na tsarin kira da catabolism na VLDL, fenofibrate yana ƙara yarda da LDL da rage abun ciki na ƙananan ƙananan abubuwa masu mahimmanci na LDL (ana lura da haɓaka cikin waɗannan LDL a cikin marasa lafiya tare da ƙwayar cutar atherogenic lipid phenotype kuma an danganta shi da babban haɗarin CHD).
A cikin nazarin asibiti, an lura cewa yin amfani da fenofibrate yana rage matakin jimlar cholesterol ta 20-25% kuma triglycerides da 40-55% tare da karuwa a matakin HDL-C ta 10-30%. A cikin marasa lafiya tare da hypercholesterolemia, a cikin abin da rage yawan Chs-LDL an rage shi zuwa 20-35%, yin amfani da fenofibrate ya haifar da raguwa a cikin masu girma: jimlar Chs / Chs-HDL, Chs-LDL / Chs-HDL da apo B / apo A-I, waɗanda alamomi ne na atherogenic hadarin.
Yin la'akari da tasirin fenofibrate akan matakin LDL-C da triglycerides, yin amfani da miyagun ƙwayoyi yana da tasiri a cikin marasa lafiya tare da hypercholesterolemia, duka biyun kuma ba su tare da hypertriglyceridemia, ciki har da hyperlipoproteinemia na biyu, alal misali, tare da nau'in ciwon sukari na 2 a yayin maganin, fenofibrate na iya raguwa sosai har ma ya ɓace gaba ɗaya. karin kudi Xc (jijiyoyin da xanthomas bututun). A cikin marasa lafiya tare da matakan fibrinogen haɓaka waɗanda suka sami magani fenofibrate, an lura da raguwa mai yawa a cikin wannan alamar, kazalika a cikin marasa lafiya da keɓaɓɓen matakan lipoprotein. A cikin lura da fenofibrate, ana lura da raguwa a cikin ƙwayar C-mai amsawa da sauran alamun alamun kumburi.
Ga marasa lafiya da dyslipidemia da hyperuricemia, ƙarin fa'ida shine cewa fenofibrate yana da tasirin uricosuric, wanda ke haifar da raguwa a cikin yawan uric acid da kusan 25%.
A cikin nazarin asibiti da kuma gwaje-gwajen dabbobi, an nuna fenofibrate don rage haɗarin platelet wanda ya haifar da adenosine diphosphate, acid na arachidonic, da epinephrine.

Pharmacokinetics na miyagun ƙwayoyi.

Damuwa
Bayan gudanar da maganin ta Tricor, an sami 145 MG na Cmax bayan sa'o'i 2-4. Cmax a cikin plasma da jimlar maganin micronozed fenofibrate a cikin nau'i na nanoparticles (Tricor 145 mg) yana da 'yancin cin abinci (saboda haka, ana iya shan miyagun ƙwayoyi a kowane lokaci, ba tare da la'akari da abincin abinci ba )
Rarraba
Fenofibroic acid yana da tabbaci kuma sama da kashi 99% yana daure ne da albumin plasma. T1 / 2 - kimanin sa'o'i 20. Maganin ba ya tara bayan kashi ɗaya kuma tare da tsawan amfani.
Tsarin rayuwa
Bayan gudanar da baki, fenofibrate yana da sauri hydrolyzed by esterases. Sai kawai babban metabolite mai aiki na fenofibrate, fenofibroic acid, ana samun su a cikin plasma. Tare da yin amfani da tsawan lokaci, maida hankali ne fenofibroic acid a cikin plasma ya kasance tsayayye, ba tare da la'akari da halayen mutum na haƙuri ba. Fenofibrate ba wani abu bane na CYP3A4, baya cikin metabolism na metabolism.
Kiwo
An cire shi da fari tare da fitsari a cikin nau'i na fenofibroic acid da concuug glucuronide. A tsakanin kwanaki 6, fenofibrate an keɓe shi gaba daya.

Bayani na gaba daya, abun da ya shafi da kuma sakin saki

Dangane da radar, Tricor magani ne mai rage karfin jiki - daga cholesterol a cikin jini. Amfani da shi yana taimakawa rage yawan kitse a jiki kuma yana hana samuwar atherosclerosis.

Fitar tasa an yi ta ne a Faransa, inda ake siyar da wannan magani ta hanyar allunan. Sakamakon maganin yana faruwa ne saboda babban bangaren, wanda shine fenofibrate.

Kuna iya amfani dashi kawai kamar yadda likita ya umarta, tunda yana da tasiri mai ƙarfi akan jiki. Wataƙila rashin daidaituwa na rikice-rikice idan an cinye ta ba lallai ba. Sabili da haka, yana yiwuwa a saya kawai ta takardar sayan magani.

Ana aiwatar da samar da kudade a cikin allunan. Babban sinadaran aiki na maganin shine fenofibrate. An haɗa shi a cikin allunan a cikin adadin 145 MG.

Baya ga shi, akwai abubuwa irinsu:

yi nasara
sabbinne,
sodium docusate,
sitiri na magnesium,
microcrystalline cellulose,
lactose monohydrate,
sodium laurisulfate,
silikion dioxide colloidal.

Wadannan abubuwa suna ba ka damar ba da maganin yadda ake so. Allunan an rufe fim ɗin (bp).

Hakanan akwai Allunan tare da kayan aiki mai aiki na 160 MG. Sun ƙunshi ƙarin kayan haɗin guda ɗaya kamar wani nau'in magani.

Kunshin magunguna suna da jeri daban-daban. Zasu iya haɗawa daga 10 zuwa 300 Allunan (sashi na 145 mg) ko daga 10 zuwa 100 guda (kashi na 160 mg).

Aikin magunguna da magunguna

Don fahimtar abin da ake nufi da wannan maganin, kuna buƙatar gano fasalin aikinsa.

Fenofibrate yana da tasiri kan triglycerides, rage adadin su. Hakanan yana taimakawa rage cholesterol a cikin jini. Wannan ya faru ne sakamakon cin zarafin mai mai.

Yin amfani da miyagun ƙwayoyi na iya rage adadin fibrinogen. Slightlyungiyar mai rauni mai rauni mai ƙarfi yana aiki akan glucose, yana taimakawa rage matakinsa. Wadannan sifofi suna sa Tricor yayi tasiri don lura da marasa lafiyar atherosclerosis wadanda ke da muradin bunkasa ciwon sukari.

Fenofibrate ya kai ƙarshen tasirin sa'o'i 5 bayan gudanarwa (wannan yana tasiri da halayen kayan jikin mutum).

Significantarancin sa yana ɗaure wa albumin, furotin plasma, samar da fenofibroic acid. Ana amfani da metabolism dinsa a cikin hanta. Abubuwan yana da tasirin gaske - kusan awanni 20 ana buƙatar cire rabin shi. Yana barin jiki ta hanjin ciki da kodan.

Manuniya da contraindications

Kuna iya gano abin da wannan kayan aiki ke taimaka daga ta hanyar nazarin umarnin da alamomi don dalilin sa.

An ba da shawarar yin amfani da shi don wannan take hakki kamar:

Tare da irin waɗannan cututtukan, ana amfani da Tricorr idan hanyoyin rashin magani ba su kawo sakamako ba.

Hakanan, likita na iya ba da wannan magani don shawo kan wasu cututtuka a matsayin wani ɓangare na maganin rikice-rikice, idan irin waɗannan ayyukan sun dace.

Dole ne a tuna cewa kasancewar alamomi don takardar sayen magani ba ya nufin yin amfani da wannan magani. Gano magungunan hana tilastawa yin watsi da amfani da ita.

Wadannan sun hada da:

mummunan cutar hanta
mummunan matsalolin koda
rashin haƙuri a cikin abun da ke ciki,
lactation
cutar hanji
shekarun yara.

Haka kuma akwai lokuta inda aka yarda da amfani da Tricor, amma yana buƙatar ƙarin taka tsantsan:

barasa
hawan jini
tsufa
take hakki a hanta da kodan.

Wannan yana nufin cewa zaku iya shan wannan magani kawai kamar yadda kwararrun likitoci suka umurce ku. Yin magani na kai na iya haifar da rikitarwa.

Alamu don amfani:

- hypercholesterolemia da hypertriglyceridemia ware ko gauraye (nau'in dyslipidemia IIa, IIb, IV) tare da rashin ingancin hanyoyin kwantar da hankali na rashin abinci (rage yawan abinci, yawan asara, yawan motsa jiki), musamman a gaban abubuwanda ke tattare da haɗarin dyslipidemia kamar hauhawar jini da shan sigari,
- hyperlipoproteinemia na sakandare, a cikin yanayin inda hyperlipoproteinemia ya ci gaba, duk da ingantaccen magani na cutar rashin lafiyar (alal misali, dyslipidemia a cikin ciwon sukari mellitus).

Sashi da hanyar gudanar da magani.

An tsara tsofaffi 1 shafin. 1 lokaci / rana
Marasa lafiya suna ɗaukan iyakoki 1. fenofibrate 200 MG na iya zuwa 1 shafin. Tricorra 145 MG ba tare da ƙarin gyaran kashi ba. Marasa lafiya suna ɗayan shafin ɗaya. fenofibrate 160 MG / rana, na iya zuwa don ɗaukar shafin 1. Tricorra 145 MG ba tare da ƙarin gyaran kashi ba.
An shawarci tsofaffi marasa lafiya su tsara daidai ma'aunin tsofaffi.
Ba a yi amfani da maganin ba a cikin marasa lafiya da cututtukan hanta.
Ana ɗaukar ƙwayar Tricor 145 MG a kowane lokaci na rana, ba tare da la'akari da cin abinci ba, ya kamata a hadiye kwamfutar hannu gaba ɗaya, ba tare da taunawa ba, tare da gilashin ruwa.
Ya kamata a sha miyagun ƙwayoyi na dogon lokaci, yayin ci gaba da bin abincin da mai haƙuri ya bi kafin fara magani tare da Trikor.

Umarnin don amfani

Ana amfani da Tricorum musamman a ciki. Lokacin amfani da miyagun ƙwayoyi a cikin sashi na 145 MG, zaka iya sha shi ba tare da la'akari da abinci ba. Idan an tsara kashi 160 na mg, magani ya kamata a sha tare da abinci. Ba lallai ba ne a niƙa shi kuma ta ɗanɗana kwamfutar hannu, yana da kyau kawai a wanke shi da isasshen ruwa.

Sashi da jadawalin gudanarwa galibi kwararre ne ya tsara shi bayan nazarin hoton cutar da cututtukan da suka danganci su. Idan yanayi bai buƙaci gyaransa ba ya nan, ana bada shawarar mai haƙuri ya ɗauki 145 ko 160 mg (1 kwamfutar hannu) kowace rana.

Hakanan ana ƙayyade tsawon lokacin aikin jiyya daban daban. A mafi yawan lokuta, yakan dauki lokaci mai tsawo. Baya ga shi, ana bada shawarar abinci. Ana amfani da tasirin magani ta hanyar sakamakon gwaje-gwaje don tantance yawan cholesterol da triglycerides.

Koda koda kwararren likita ne ya tsara shi, mai haƙuri yakamata ya lura da canje-canje a yanayinsa. Bayyanar da mummunan sakamako ko rashin sakamako yana nufin cewa Tricor bai dace da wannan yanayin ba. Hakanan yana iya nuna buƙatar daidaitawar sashi ko kasancewar ɓoyayyen abubuwan hana haihuwa.

Bidiyo game da cholesterol da ayyukanta a cikin jiki:

Marasa lafiya na musamman da kuma Jagorori

Yawan marasa lafiya don waɗanda aka ba da shawarar ta musamman lokacin amfani da Tricor an haɗa su da rukuni na mutane:

Mata yayin daukar ciki. Aiki abu na miyagun ƙwayoyi ne contraindicated, saboda haka, da amfani da shi an haramta a wannan lokacin.
Iyayen mata masu shayarwa. Sakamakon fenofibrate akan ingancin madara mai nono da kuma akan jariri ba'a kafa shi ba. A wannan batun, likitoci ba sa amfani da Trikor don irin waɗannan marasa lafiya.
Yara. A karkashin shekara 18, ba a yi amfani da wannan magani ba, saboda ba a san yadda saitinsa zai iya shafar jikin yara ba.
Tsofaffi mutane. Don wannan rukuni na marasa lafiya, ana amfani da maganin yana da karɓa. Amma kafin alƙawarin sa, marasa lafiya suna buƙatar jarrabawa don guje wa rikice-rikice masu yiwuwa. Hakanan ana rage rage sashi.

Sauran mutane (in babu contraindications) na iya amfani da maganin kamar yadda likita ya umarta.

Dole ne a yi taka tsantsan yayin amfani da Traicor a gaban waɗannan raunin da ke cikin jiki:

Cutar koda. A cikin mummunan cututtuka na wannan sashin, an haramta amfani da miyagun ƙwayoyi. Deviarancin karkacewa a cikin aikin kodan suna buƙatar kulawa da kulawa akai-akai game da aikin jiyya tare da amfani.
Cutar hanta. Don ƙananan matsalolin hanta, likita zai iya ba da maganin Tricor bayan jarrabawa. Violationsayyadaddun ƙetare dalilai ne na ƙin shan miyagun ƙwayoyi.

Fenofibrate na iya shafar aikin hanta, don haka koda a cikin rashin damuwa a wannan yankin, kuna buƙatar duba yanayin shi lokaci-lokaci. Hakanan, a ƙarƙashin rinjayar miyagun ƙwayoyi, sigogin coagulation na jini na iya canzawa - wannan kuma yana buƙatar sarrafawa.

Side effects da yawan abin sama da ya kamata

Lokacin amfani da Tricorr, tasirin sakamako na iya faruwa. Tare da babban tasiri, dole ne ku ƙi jiyya tare da wannan magani.

Babban sakamako masu illa na miyagun ƙwayoyi sun hada da:

tashin zuciya
ciwon kai
jijiyar wuya
increasedara yawan ƙwayoyin farin jini,
karuwar gas,
zawo
ciwon ciki
myositis
cututtukan mahaifa
maganin ciwon huhu
itching
fata rashes,
gallstones
alopecia
rage yin jima'i.

Idan ya cancanta, likita ya kamata ya magance su. Babu takamaiman maganin rigakafi, sabili da haka, ana bai wa marasa lafiya magani na alama.

Har yanzu ba a rubuta adadin abubuwan da suka shafi yawa ba Ana ba da shawarar cewa maganin tiyata ya kamata ya taimaka da ganowa.

Hadin gwiwar Magunguna da Analogs

Gwanin ƙwaƙwalwar ƙwaƙwalwa ya ƙunshi haɗuwa daidai na magungunan da aka yi amfani da su. Idan magani daya ya gurbata tasirin wani, sakamakon zai iya zama wanda ba zai yiwu ba. Sabili da haka, kuna buƙatar yin la'akari da yadda Tricor zai iya shafar waɗancan magungunan da ake amfani da su a layi ɗaya da shi.

Tsanani yana buƙatar haɗuwa da wannan magani tare da:

magungunan anticoagulants (fenofibrate suna ƙoƙarin inganta tasirin su, wanda ke haifar da haɗarin zubar jini),
Cyclosporine (ana iya lalata aikin koda),
statins (akwai haɗarin cutarwa mai guba a kan tsokoki).

Don wasu kwayoyi, ba a lura da canje-canje masu mahimmanci ba. Koyaya, mai haƙuri dole ne ya sanar da likita game da duk magungunan da yake amfani da shi don ƙwararren likita ya iya ba da cikakkiyar magani.

Dalilan yin amfani da kayan aikin analog na iya bambanta. Mafi sau da yawa, marasa lafiya suna neman analogues mai rahusa, tunda ɗaukar magani mai tsada akan ci gaba mai gudana aiki ne mai tsada sosai.

Wasu kuma suna damuwa da illolin da ke haifar musu da wahala su yi aiki cikakke. A wannan batun, kwararru galibi suna buƙatar zaɓar kwayoyi tare da tasirin irin wannan.

Wadannan sun hada da:

Wasu daga cikin kudaden da aka lissafa suna da kayan kama da na Traicor. Ga waɗansu, tasirin kama ɗaya halayen ne, duk da bambance-bambance a cikin kayan haɗin.

Don amfani da analog, dole ne ka nemi likitanka. Kai magani kai koyaushe yana da haɗari, saboda haka kana buƙatar tabbatar da cewa zaɓaɓɓen magani ya dace da wani mai haƙuri.

Mai haƙuri ra'ayi

Abun sake dubawa game da kwayar Tricor galibi tabbatacce ne - da yawa suna lura da fa'idarsa mai amfani ga jiki da rage ƙwaƙwalwar jini.

Saw Tricor watanni shida da suka gabata kamar yadda likita ya umarta. Godiya gareshi, ta sami jin zafi a ƙafafunta da gwiwoyinta. Hawan jini na ya ragu kuma, ƙwayoyina na raguwa. Ta ji dadi har sai da ta daina shansa. Dukkanin alamu sun dawo, saboda haka ina tunanin tambayar likita a karo na biyu.

Magungunan sun taimaka mini in kawar da matsalar ƙwayar cholesterol. Amma saboda shi, na kamu da mashako - a bayyane yake, wasu nau'in sakamako masu illa. Ya zama dole a ki amfani.

Na kasance ina amfani da samfurin tsawon watanni 3 yanzu. Da farko babu wani tasiri mai kyau, kawai rauni da ciwon kai. Sannan komai ya koma daidai, gwaje-gwajen sun inganta. Haka nan azabar kafafu da hannayensa sun tsaya, cramps din ya bace. Na kan tashi cikin dare saboda su, amma yanzu wannan ba ya faruwa. Ina jin karin ƙarfi - kamar in sake sabuntawa.

Kudin maganin yana dogara ne akan sashi na sashi mai aiki wanda yake kunshe da adadin allunan a cikin kunshin. Don kayan haɗi tare da allunan 30 (145 MG) kana buƙatar ba daga 750 zuwa 900 rubles. A sashi na 160 MG da irin kayan marufi iri ɗaya, farashin Tricor zai kasance daga 850 zuwa 1100 rubles.