Umarnin don maganin Rotomox > Jiyya da rigakafin

Yadda ake amfani da umarnin shafinmu don allunan da sauran kwayoyi OnlineManuals.ru
Manufarmu ita ce samar muku da sauri zuwa ga abin da ke cikin umarnin don maganin Rotomox. Tare da taimakon kallon yanar gizo, zaka iya duba abinda ke ciki na umarnin mai magani Rotomox.

Don saukaka muku
Idan kun samo asali ta hanyar umarnin don amfani da miyagun ƙwayoyi Rotomox kai tsaye akan shafin, bai dace muku ba, akwai mafita guda biyu:

• Duba cikin yanayin allo gabaɗaya - yana da sauƙi duba umarnin don amfani (ba tare da saukar dashi zuwa kwamfutarka ba), zaku iya amfani da yanayin yanayin cikakken allo. Don duba umarnin "don Rotomox a cikin cikakken allo, yi amfani da maɓallin" Buɗe a cikin Pdf-mai kallo ".
• Zazzagewa zuwa kwamfuta - Hakanan zaka iya sauke umarnin don shirin Rotomox akan kwamfutarka kuma adana shi a cikin fayiloli.

Mutane da yawa sun fi son karanta takardu ba akan allo ba, amma a buga. Hakanan an bayar da damar buga umarnin don magunguna da allunan a shafin yanar gizon mu, kuma zaku iya amfani da ita ta danna maɓallin “bugawa” a cikin mai kallon Pdf. Babu buƙatar buga duk umarnin don shirye-shiryen Rotomox, zaku iya zaɓar kawai shafukan da ake buƙata na umarnin don amfani da takamaiman magani ko allunan.

Umarnin don amfani da miyagun ƙwayoyi Rotomox za'a iya saukar da shi ƙasa:

Kungiyar magunguna

Dangane da Maganar Likitocin Likitoci (2009), moxifloxacin an nuna shi don magance cututtukan cututtukan da ke haifar da cututtukan ƙwayoyin cuta a cikin marasa lafiyar (fiye da shekaru 18).

Cututtukan ƙwayar cuta na ƙwayar cutalalacewa ta Kwayar cutar huhu da ƙwayoyin cuta, da cutar huemophilus ko Moraxella catarrhalis.

Wucewar cutar mashako da ke hade da kamuwa da cuta ta kwayan cuta(Streptococcus pneumoniae, Haemophilus mura, Haemophilus parainfluenzae, Klebsiella ciwon huhu, methicillin-m Amintakarwa ko Moraxella catarrhalis).

Cutar huhu da al'umma ta samulalacewa ta Kwayar cutar huda ciki (haɗe da lalacewa ta hanyar ƙananan ƙwayoyin cuta tare da juriyar ƙwayoyin cuta masu guba *), Haemophilus mura, Moraxella catarrhalis, methicillin-m Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma ciwon huhu ko Chlamydia cutar huhu.

Kwayoyin cuta marasa illa na fata da kayan aikintasanadin methicillin-m Amintakarwa ko Pyogenes mai ƙarfi.

Abun ciki na cikigami da cututtukan cututtukan cututtukan ƙwayoyin cuta irin su ƙarancin kumburin ciki da ya haifar Escherichia coli, Bacteroides fragilis, Stregincoccus anginosus, Hanyar maƙarƙashiya, Encerococcus faecalis, Kare mirabilis, Clostridium turare, Bacteroides thetaiotaomicron ko Kawaicin spp.

Kwayoyin cuta masu kamuwa da cuta na fata da kayan aikintasanadin methicillin-m Amintakarwa, Escherichia coli, Klebsiella ciwon huhu ko Enterobacter cloacae.

* - Cututtukan da suke tsayayya da juriya na kwayoyi masu yawa Kwayar cutar huda ciki - MDRSP), gami da nau'ikan da aka sani da PRSP (Penicillin-resistant S. ciwon huhu) da siraran da zasu iya jurewa biyu ko fiye na kwayoyi masu zuwa: penicillin (tare da MPC ≥2 μg / ml), cephalosporins na biyu (misali cefuroxime), macrolides, tetracyclines da trimethoprim / sulfamethoxazole.

Haihuwa da lactation

Amfani da shi yayin daukar ciki yana yiwuwa idan ana tsammanin tasirin farjin cutar ya wuce hadarin cutar tayin (ba a gudanar da nazarin ingantaccen nazari game da amincin amfani da mata masu juna biyu ba).

Tasirin Teratogenic. Moxifloxacin bashi da tasirin teratogenic lokacin da ake gudanar da shi ga berayen masu ciki yayin kwayoyin a cikin manyan kwayoyin cutar da suka fi 500 mg / kg / rana, wanda yayi daidai da 0.24 MPDs (bisa ƙididdigar AUC), amma an sami raguwar yawan fitsarin jikin mutum da kuma ɗan jinkiri a tsarin ƙashi, fetotoxicity.

Lokacin da iv-ke gudanar da berayen mai ciki tare da moxifloxacin a kashi 80 MG / kg / rana (kusan sau 2 sama da MPD, ana kirga shi akan jikin mutum (MG / m 2), an lura da guba ga mace da ƙarancin tasiri akan tayin, nauyi da bayyanar ƙwayar cuta. Tare da iv allurai sama da 80 mg / kg / day, ba a lura da wani tasirin teratogenic .. Gudanarwar IV zuwa zomaye yayin daukar ciki yayin lokacin allurai na kwayoyin 20 mg / kg / rana (kusan daidai yake da MPD lokacin da aka sha ta a baki) ya haifar da raguwar nauyin jikin tayi. da kuma jinkirta fitar da kasusuwa Signs Alamomin yawan guba ga mata Akwai rauni, ɓarna, raguwar ci abinci, raguwar yawan shan ruwa, da kuma rashin ƙarfi a cikin waɗannan allurai Babu wata shaida ta baka ta teratogenicity a cikin birai Cynomolgus a kashi 100 mg / kg / day (2.5 MRDI). Ya karu da kashi 100 MG / kg / rana. A cikin berayen, an gano cewa tare da maganin ƙwayar cuta na 500 MG / kg / rana, an lura da tasirin masu zuwa: ƙaramin ƙaruwa a cikin tsawon lokacin ciki, asarar haihuwa, rage nauyi a cikin jariri s matasa, rage neonatal rayuwa. Sakamakon mai guba na moxifloxacin akan kwayoyin masu juna biyu ya bayyana ne yayin da aka gudanar da kashi 500 MG / kg / rana akan berayen yayin daukar ciki.

FDA KYAUTA A CIKINSA - C.

Ana fitar da Moxifloxacin a cikin nono na berayen. Tunda moxifloxacin zai iya shiga cikin madarar nono na mata masu shayarwa kuma yana haifar da mummunar illa a cikin jarirai masu shayarwa, mata masu shayarwa ya kamata su dakatar da ko dai su shayar da mama ko kuma suyi amfani da moxifloxacin (da aka baiwa mahimmancin maganin ga mahaifiyar).

Side effects

A lokacin gwaji na asibiti wanda ya shafi fiye da 9,200 marasa lafiya waɗanda suka karbi moxifloxacin magana da iv (sama da marasa lafiya 8600 sun karɓa shi a cikin kashi 400 MG), yawancin sakamako masu illa da aka lura sun kasance masu laushi da matsakaici kuma basu buƙatar dakatar da magani ba. An daina amfani da maganin saboda tasirin sakamako masu illa da ke tattare da maganin a cikin 2.9% na marasa lafiya lokacin da aka sha shi a baki da kuma 6.3% na marasa lafiya da suka karɓa biyun (iv da baki).

Abubuwanda suka biyo baya sune aka tantance aƙalla aƙalla yiwuwar amfani da kwayoyi kuma an lura dasu a cikin ≥2% na marasa lafiya: tashin zuciya (6%), zawo (5%), dizziness (2%).

Magungunan da aka bayyana ta hanyar asibiti wanda aka tantance kamar aƙalla yiwuwar suna da alaƙa da magani kuma an lura da su a cikin QT, leukopenia, rage prothrombin (ƙara yawan lokacin prothrombin / ƙara yawan INR), eosinophilia, thrombocythemia, ECG, hauhawar jini, hauhawar jini, jijiyoyin mahaifa, haɓaka prothrombin (raguwa a cikin lokacin prothrombin / raguwa a cikin INR), thrombocytopenia, supreyventricular tachycardia, raguwa a cikin thromboplastin, ventricular tachycardia.

Daga narkewa: % 0% ciki har da jin zafi a kirji, baya, kafafu, ciwo na pelvic, asma, kumburi fuska, hyperglycemia, hyperlipidemia, hauhawar jini, hypesthesia, photoensitivity / phototoxicity halayen, syncope, tenopathy.

A bincike-bayan-tallace-tallace An ba da rahoton sakamako masu biyo baya: halayen anaphylactic, angioedema (gami da laryngeal edema), gazawar hanta (gami da cutar kansa), hepatitis (yawancin cholestatic), halayen hoto / halayen hototoxicity, halayen psychotic, Stevens-Johnson syndrome, jijiyoyin wuya, fashewa mai guba na necrolysis mai guba da ventricular tachyarrhythmia (gami da halartattun lokuta lokuta na kamuwa da bugun zuciya da torsade de maki yawanci a cikin marasa lafiya da concomitant mai girma proarrhythmic bayyanar cututtuka).

Kariya da aminci

A kan asalin moxifloxacin, karuwa a cikin tazara na QT mai yiwuwa ne, saboda haka, ya kamata a yi amfani da shi da taka tsantsan a cikin marasa lafiya da ke karbar wasu kwayoyi a lokaci guda wanda kuma ya tsawaita tazara ta QT (cisapride, erythromycin, antipsychotics, tricyclic antidepressants), saboda ƙari sakamako ba zai iya fitar da mulki.

Tare da taka tsantsan, an wajabta su akan asalin magungunan antiarrhythmic na aji IA (quinidine, procainamide) ko aji III (amiodarone, sotalol).

Saboda ƙarancin bayanan asibiti game da amfani da moxifloxacin a cikin marasa lafiya tare da bradycardia na asibiti kuma tare da alamun ischemia na myocardial m, ya kamata a yi amfani dashi da taka tsantsan a cikin waɗannan marasa lafiya. Matsakaicin tsawaita tazara na QT na iya ƙaruwa tare da haɓaka yawan abu da haɓaka adadin kumburi tare da gwamnatin iv, sabili da haka, shawarar da aka ba da shawarar da lokacin sarrafa maganin bai kamata a wuce ba. Increasearuwar tazara tsakanin QT na iya haifar da haɓakar haɗarin arrhythmias, ciki har da torsade de maki. Babu wani lamunin yanayin rashin lafiya ko mace-mace da ke da alaƙa da tsawaita tazara na QT a cikin gwaji na asibiti tare da yin amfani da moxifloxacin a cikin marasa lafiya fiye da 9,200 (ciki har da marasa lafiya 223 tare da hypokalemia a farkon magani), kuma babu karuwa a cikin mace 18,000 marasa lafiya suna shan moxifloxacin a ciki, a lokacin binciken bayan-tallace-tallace ba tare da kulawar ECG ba.

Amfani da quinolones yana da alaƙa da yuwuwar haɗarin kamuwa da cututtukan zuciya, kazalika da sauran rikice-rikice na tsarin juyayi na tsakiya (jin ƙima, rikicewa, rawar jiki, hallucinations, ɓacin rai, da wuya, tunani kai ko kashe kansa). Ana iya lura da waɗannan halayen bayan kashi na farko na miyagun ƙwayoyi. Idan akwai irin wannan halayen, moxifloxacin yakamata a dakatar dashi. Kamar sauran quinolones, moxifloxacin yakamata a yi amfani dashi tare da taka tsantsan a gaban ko tuhuma game da cututtukan ƙwayar jijiya na tsakiya (gami da maƙarƙashiya arteriosclerosis, amai) ko kuma a gaban sauran abubuwan da ke haifar da tashin hankali ko raguwa a bakin kife.

An bayar da rahoton maganganun ci gaban mummunan halayen anaphylactic yayin shan maganin a cikin marasa lafiya da ke ɗaukar quinolones, gami da moxifloxacin. A wasu halayen, waɗannan halayen suna haɗuwa da rushewar zuciya, asarar rai, fainting, kumburi daga makogwaro ko fuska, dyspnea, urticaria, da itching. Game da halayen anaphylactic, ana buƙatar gudanar da aikin epinephrine na gaggawa. Idan fatar fata ko wasu alamun rashin amsawar jiki sun bayyana, ya kamata a dakatar da maganin moxifloxacin kuma yakamata a aiwatar da matakan farfadowa (idan ya cancanta).

Yana da mahimmanci la'akari da yiwuwar haɓakar cututtukan cututtukan ƙwayar cuta, idan zawo ya bayyana a cikin marasa lafiya da ke karɓar wakilai na ƙwayoyin cuta. Yin jiyya tare da wakilai na ƙwayoyin cuta yana haifar da canji na ƙwanƙwarar al'ada na babban hanjin kuma yana iya haifar da haɓakar ƙwaƙwalwar clostridia. Lokacin da aka gano cutar cututtukan cututtukan cututtukan ƙwayar cuta, yakamata a fara amfani da maganin da ya dace.

A lokacin jiyya tare da fluoroquinolones, ciki har da moxifloxacin, ci gaban tendonitis da rushewar tendon (Achilles da sauransu) mai yiwuwa ne. Abubuwan lura bayan tallace-tallace sun ba da rahoton karuwar haɗari a cikin marasa lafiya da ke karɓar corticosteroids na lokaci guda, musamman waɗanda shekarunsu suka wuce 60. Sabili da haka, lokacin jin zafi, kumburi ko katsewar jijiyoyin sun faru, ya kamata a dakatar da gudanar da moxifloxacin. Ya kamata a ɗauka a hankali cewa rushewar jijiya na iya faruwa yayin ko bayan maganin quinolone (gami da moxifloxacin).

Umarni na musamman

Kafin magani, yakamata ayi gwaje-gwajen da suka dace don gano ƙwayoyin cututtukan da suka haifar da cutar da kuma tantance ƙwarewar moxifloxacin. Ana iya fara amfani da maganin moxifloxacin kafin a sami sakamakon wadannan gwaje-gwaje. Lokacin da aka san sakamakon gwaji, yakamata a ci gaba da yin amfani da maganin.