Siofor 1000: umarnin don amfani da allunan don ciwon sukari

Siofor 1000: umarnin don amfani da sake dubawa

Sunan Latin: Siofor 1000

Lambar ATX: A.10.B.A.02

Ingantaccen kayan aiki: Metformin (Metformin)

Mai kera: BERLIN-CHEMIE, AG (Jamus), DRAGENOPHARM APOTHEKER PUSCHL, GmbH & Co. KG (Jamus)

Ofaukaka bayanin da hoto: 10.24.2018

Farashin kuɗi a cikin kantin magani: daga 383 rubles.

Siofor 1000 magani ne mai haɓaka.

Formaddamar da tsari da abun da ke ciki

Sedfor nau'i na Siofor 1000 - Allunan mai rufi: farin, oblong, tare da daraja a daya da kuma wedge-dimbin yawa "karye-tab" hutu a daya gefen (a cikin blisters na 15 inji mai kwakwalwa., A cikin kwali na kwali na 2, 4 ko 8 blisters).

Abun ciki 1 kwamfutar hannu:

• abu mai aiki: metformin hydrochloride - 1 g,
• karin abubuwan taimako: magnesium stearate - 0.005 8 g, povidone - 0.053 g, hypromellose - 0.035 2 g,
• harsashi: titanium dioxide (E 171) - 0.009 2 g, macrogol 6000 - 0.002 3 g, hypromellose - 0.011 5 g.

Pharmacodynamics

Metformin, abu mai aiki na miyagun ƙwayoyi, ya kasance ga rukuni na biguanides.

Ayyukan Siofor 1000, saboda metformin:

• yana da tasirin antihyperglycemic,
• yana samar da raguwa a cikin kwaskwarimar glucose da jini na postprandial
• baya motsa insulin insulin, kuma sabili da haka baya haifar da yawan aiki,
• yana rage haɓakar glucose a cikin hanta ta hanyar hana glycogenolysis da gluconeogenesis,
• yana ƙara ƙarfin jijiyoyin jiki zuwa insulin, wanda ke haifar da ingantaccen amfani da ɗaukar glucose a cikin keɓaɓɓiyar,
• yana hana sha glucose a cikin hanjin,
• yana ƙarfafa aikin haɗin glycogen ta hanyar aiki akan glycogen synthetase,
• yana haɓaka ƙarfin sufuri na duk abubuwan da ake sani yanzu na membrane kai sunadaran glucose,
• da kyau yana shafar maganin ƙwayar cuta, yana rage haɗuwa da ƙwaƙwalwar ƙwayar cuta gaba ɗaya, ƙwaƙwalwar ƙwayar cuta da ƙananan ƙwayoyin cuta.

Pharmacokinetics

• sha: bayan an sami kula da baka daga hancin gastrointestinal, C_max Ana samun mafi girman yawan plasma bayan awa 2.5 sannan kuma lokacin ɗaukar matsakaicin matakin bai wuce 4 notg a 1 ml ba. A lokacin abinci, sha yana ragewa kuma yana rage gudu kaɗan,
• rarrabuwa: tarawa a cikin kodan, hanta, tsokoki, glandon salivary, yana shiga cikin sel jini. Cikakken bayanin halitta a cikin marasa lafiya masu lafiya ya bambanta daga 50 zuwa 60%. A zahiri ba a ɗaure shi ga furotin jini na jini ba, V_d (matsakaicin girman rarraba) - 63-76 l,
• excretion: kodan da ba'a canza shi ba daga kodan, keɓaɓɓe renal - fiye da 400 ml a cikin 1 min. T_1/2 (kawar da rabin rayuwa) - kimanin awowi 6.5. Shakar hanyoyin karafa ta hanyar rage aiki a cikin koda, a hankali, kawarda rabin rayuwa zaiyi tsawo, kuma tattara abu a cikin jini yana kara hauhawa.

Alamu don amfani

An tsara Siofor 1000 ga marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na sukari na 2, musamman ga kiba, lokacin da tsarin abinci da aikin jiki ba su da tasiri.

Magungunan a cikin yara sama da shekaru 10 ana amfani dashi azaman monotherapy ko kuma a hade tare da insulin, a cikin manya azaman maganin monotherapy ko kuma wani ɓangare na haɗakar magani tare da wasu magungunan maganganu na baka da insulin.

Aikin magunguna

Magungunan rigakafin jini daga ƙungiyar biguanide. Yana ba da raguwa a cikin tasoshin tasoshin jini da na bayan jini da kuma bayan jini. Ba ya tayar da rufin insulin kuma sabili da haka baya haifar da hypoglycemia. Tabbatar da aikin metformin yana yiwuwa ne akan waɗannan hanyoyin: - rage samar da glucose a cikin hanta sakamakon hana gluconeogenesis da glycogenolysis, - ƙwarewar ƙwayar tsoka zuwa insulin kuma, saboda haka, haɓaka haɓakar glucose a cikin haɓakar da kuma amfani dashi, - hana haɓakar glucose a cikin hanji. Metformin, ta hanyar aikinsa akan glycogen synthetase, yana ƙarfafa haɗin glycogen kira. Yana kara karfin jigilar dukkan abubuwan jigilar kayayyaki na glucose, wanda aka sani zuwa yau. Ko da kuwa tasirin tasirin glucose na jini, yana da tasiri mai amfani ga metabolism na lipid, yana haifar da raguwa cikin jimlar cholesterol, ƙarancin ƙarancin cholesterol da triglycerides.

Yanayi na musamman

Kafin tsara magungunan, da kowane watanni 6, wajibi ne don saka idanu akan aikin hanta da koda. Wajibi ne a kula da matakin lactate a cikin jini akalla sau 2 a shekara. Ya kamata a sauya hanyar kulawa tare da Siofor® 500 da Siofor® 850 tare da wasu magungunan hypoglycemic (alal misali, insulin) kwanaki 2 kafin aikin X-ray tare da iv na iodinated kwatankwacin wakilai, da kuma kwanaki 2 kafin tiyata a karkashin maganin sa maye, kuma ci gaba da wannan far don wani 2 na kwanaki bayan wannan gwajin ko bayan tiyata. A haɗuwa da jiyya tare da maganin ƙwaƙwalwar ƙwayar mahaifa, lura da hankali kan matakan glucose na jini ya zama dole. Tasiri a kan ikon tuka motoci da hanyoyin sarrafawa Lokacin amfani da Siofor®, ba a ba da shawarar shiga cikin ayyukan da ke buƙatar taro da saurin psychomotor ba saboda haɗarin cutar hawan jini.

• Metformin hydrochloride 1000 MG na mahaɗan: povidone K25, hypromellose, magnesium stearate, macrogol 6000, titanium dioxide (E171)

Hulɗa da ƙwayoyi

Tare da yin amfani da lokaci guda tare da abubuwan da suka samo asali na sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, Clofibrate Kalam, cyclophosphamide, beta-blockers, yana yiwuwa a ƙara tasirin hypoglycemic na Siofor®. Tare da yin amfani da lokaci guda tare da corticosteroids, hanawar hana haihuwa, epinephrine, sympathomimetics, glucagon, hormones na thyot, abubuwan asalin kwayoyin halittar phenothiazine, abubuwan nicotinic acid, yana yiwuwa a rage tasirin hypoglycemic na Siofor®. Siofor® na iya raunana tasirin maganin rashin daidaituwa. Tare da amfani da lokaci ɗaya tare da ethanol, haɗarin haɓaka lactic acidosis yana ƙaruwa. Hulɗa tare da Pharmacokinetic na furosemide yana ƙara Cmax na metformin a cikin jini. Nifedipine yana ƙara yawan sha, Cmax na metformin a cikin jini, yana tsawaita fitowar ta. Shirye-shiryen cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin

Yanayin ajiya

• adana a zazzabi daki 15-25
• nisantar da yara

Bayanin da Bayanan Magunguna na Jiha suka bayar.

• Glycomet-500, Glycon, Glyformin, Glyukofag, Metformin.

Lactic acidosis wani mummunan yanayin cututtukan cuta ne wanda ba kasafai yake faruwa ba, yana da alaƙa da tara ƙwayar lactic acid a cikin jini, wanda mai haɗarin metformin zai iya haifarwa. Abubuwan da aka bayyana game da ci gaban lactic acidosis a cikin marasa lafiya na karɓar metformin an lura da su musamman a cikin marasa lafiya da ke fama da ciwon sukari tare da gazawar koda. Yin rigakafin maganin lactic acidosis ya ƙunshi gano duk abubuwan haɗari masu haɗari, irin su cututtukan ƙwayar cuta, ketosis, yin azumi mai yawa, yawan shan giya, gazawar hanta, da duk wani yanayin da ke hade da hypoxia. Idan kuna zargin ci gaban lactic acidosis, ana ba da shawarar cire magunguna da gaggawa asibiti da gaggawa.

Tunda ƙananan ƙwayoyin metformin sun fitar da kodan, yakamata a tantance ƙwaƙwalwar creatinine a cikin jini kafin yin jiyya, sannan a kai a kai. Ya kamata a kula da kulawa ta musamman idan akwai haɗarin aikin mara nauyi, alal misali, a farkon farfajiya tare da magungunan antihypertensive, diuretics ko NSAIDs.

Jiyya tare da Siofor ® ya kamata a maye gurbin shi na ɗan lokaci tare da wasu magungunan hypoglycemic (alal misali, insulin) sa'o'i 48 kafin da kuma awanni 48 bayan yin X-ray tare da iv na wakilcin wakilan iodinated.

Yin amfani da miyagun ƙwayoyi Siofor ® dole ne a dakatar da shi awanni 48 kafin aikin tiyata da aka shirya a ƙarƙashin maganin sa barci na gaba ɗaya, tare da maganin kashin baya ko na maganin tashin hankali. Ya kamata a ci gaba da warkewa a jiki bayan sake dawo da abinci na baka ko kuma a baya fiye da awanni 48 bayan tiyata, ƙarƙashin tabbaci na aikin koda na al'ada.

Siofor ® ba musanyawa ga abinci da motsa jiki na yau da kullun ba - dole ne a haɗar da waɗannan nau'o'in maganin dangane da shawarar likita. A yayin jiyya tare da Siofor ®, duk mara lafiya yakamata a bi hanyar rage cin abinci tare da cin abincin koda a cikin kullun. Marasa lafiya masu nauyin jiki yakamata su bi tsarin rage kalori.

Ya kamata a gudanar da gwaje-gwajen gwaje-gwaje na marasa lafiya ga masu fama da ciwon sukari mellitus akai-akai.

Kafin amfani da Siofor ® a cikin yara masu shekaru 10 zuwa 18, yakamata a tabbatar da bayyanar cututtuka na nau'in ciwon sukari na 2.

A cikin karatun nazarin asibiti na shekara guda, ba a lura da tasirin metformin kan ci gaba da haɓakawa ba, har ma lokacin balaga na yara, ba a lura da bayanai kan waɗannan alamomin tare da amfani mai tsawo ba. A wannan batun, ana ba da shawarar saka idanu sosai game da sigogi masu dacewa a cikin yaran da ke karɓar metformin, musamman a cikin lokacin prepubertal (10-12 shekaru).

Monotherapy tare da Siofor ® ba ya haifar da hypoglycemia, amma ana yin taka tsantsan lokacin amfani da miyagun ƙwayoyi tare da abubuwan insulin ko abubuwan da suka samo asali na sulfonylurea.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Yin amfani da Siofor ® ba ya haifar da hypoglycemia, saboda haka, ba ya tasiri da ikon tuki motocin da kuma kula da hanyoyin.

Tare da yin amfani da magani na lokaci guda Siofor ® tare da wasu magungunan hypoglycemic (sulfonylureas, insulin, repaglinide), haɓaka yanayin hypoglycemic mai yiwuwa ne, saboda haka ana buƙatar taka tsantsan lokacin tuki motocin da sauran ayyukan haɗari masu haɗari waɗanda ke buƙatar taro da saurin halayen psychomotor.

Babban contraindications

Ba'a bada shawarar amfani da miyagun ƙwayoyi don amfani da irin waɗannan halaye ba:

1. akwai wuce haddi a hankali ga babban aiki mai aiki (metformin hydrochloride) ko wasu abubuwan maganin,
2. batun bayyanar cututtuka na rikitarwa ga tushen ciwon sukari. Wannan na iya zama ƙaruwa mai ƙarfi a cikin tattarawar glucose a cikin jini ko kuma wani muhimmin hadawan abu na jini saboda yawan jikin jikin ketone. Alamar wannan yanayin zai kasance mai zafi a cikin rami na ciki, numfashi mai wahala sosai, bacci, da kuma sabon wari, mara amfani mara amfani daga bakin,
3. hanta da cututtukan koda,

Yanayin matsanancin yanayi wanda zai iya haifar da cutar koda, misali:

• cututtuka
• babban asarar ruwa saboda amai ko gudawa,
• kasa isar da jini
• lokacin da ya zama tilas a gabatar da wakilin da ya kunshi aidin. Wannan na iya buƙatar waɗannan karatun likita daban-daban, kamar su-ray,

Don waɗannan cututtukan waɗanda zasu iya haifar da matsananciyar ƙwayar oxygen, misali:

1. bugun zuciya
2. mai aiki mai ɗaukar hoto,
3. kasa isar da jini
4. bugun zuciya kwanannan
5. yayin mummunan maye na giya, kazalika da shan giya.

Idan kuma akwai masu juna biyu da shayarwa, haramun ne yin amfani da Siofor 1000. A irin waɗannan yanayi, likitan halartar ya kamata ya maye gurbin maganin tare da shirye-shiryen insulin.

Idan akalla ɗayan waɗannan yanayin ya faru, dole ne ka sanar da likitanka game da shi.

Aikace-aikacen da sashi

Dole ne a sha maganin Siofor 1000 a cikin madaidaitan yadda aka tsara kamar yadda likita ya umarta. Don kowane alamun bayyanar cututtuka, ya kamata ka nemi likita.

Ya kamata a ƙaddara adadin kudade a kowane yanayi daban-daban. Nadin zai dogara ne akan matakin glucose a cikin jini. Wannan yana da matukar muhimmanci ga lura da duk nau'ikan marasa lafiya.

Ana yin Siofor 1000 a cikin tsarin kwamfutar hannu. Kowane kwamfutar hannu mai rufi yana dauke da nauyin 1000 na metformin. Bugu da ƙari, akwai wani nau'i na sakin wannan magani a cikin nau'ikan allunan 500 MG da 850 MG na abu a cikin kowane.

Za a bayar da ingantaccen tsarin kulawa da magani mai zuwa:

• yin amfani da Siofor 1000 azaman magani mai zaman kanta,
• haɗuwa tare da wasu magunguna na baka wanda zai iya rage sukarin jini (a cikin majinyata),
• hadin gwiwa tare da insulin.

Marasa lafiya tsofaffi

Kashin farko na yau da kullun za a haɗa da Allunan mai rufi tare da kwamfutar hannu mai rufi (wannan zai dace da 500 MG na metformin hydrochloride) sau 2-3 a rana ko 850 MG na abu 2-3 sau a rana (irin wannan adadin Siofor 1000 ba zai yiwu ba), umarnin don amfani ya nuna a fili.

Bayan kwanaki 10-15, likita mai halartar jiki zai gyara mahimmancin sashi gwargwadon yawan glucose a cikin jini. A hankali, ƙarar ƙwayar za ta ƙaru, wanda ya zama mabuɗin mafi kyawun haƙuri ga ƙwayoyi daga tsarin narkewa.

Bayan yin gyare-gyare, kashi zai zama kamar haka: 1 kwamfutar hannu Siofor 1000, mai rufi, sau biyu a rana. Volumearar da aka nuna zata dace da 2000 mg na metformin hydrochloride a cikin sa'o'i 24.

Matsakaicin adadin yau da kullun: 1 kwamfutar hannu Siofor 1000, mai rufi, sau uku a rana. Volumearar zata dace da 3000 MG na metformin hydrochloride kowace rana.

Yara daga shekaru 10

Thearancin da aka saba da shi shine 0.5 g na kwamfutar hannu mai rufi (wannan zai dace da 500 MG na metformin hydrochloride) sau 2-3 a rana ko 850 MG na abu 1 a rana kowace rana (irin wannan kashi ba zai yiwu ba).

Bayan makonni 2, likita zai daidaita matakan da ake buƙata, farawa daga tattarawar glucose a cikin jini. A hankali, ƙara Siofor 1000 zai karu, wanda ya zama mabuɗin don ingantaccen haƙuri game da ƙwayar cuta daga ƙwayar gastrointestinal.

Bayan yin gyare-gyare, kashi zai zama kamar haka: 1 kwamfutar hannu, mai rufi, sau biyu a rana. Irin wannan girma zai dace da 1000 mg na metformin hydrochloride kowace rana.

Matsakaicin adadin kayan aiki mai aiki zai zama 2000 MG, wanda yayi daidai da kwamfutar hannu 1 na fim ɗin Siofor 1000 mai rufi.

Rashin Amincewa da Yawan doauka

Kamar kowane magani, Siofor 1000 na iya haifar da wasu sakamako masu illa, amma suna iya fara haɓaka nesa da duk marasa lafiya da ke shan maganin.

Idan yawan ƙwayar ƙwayar cuta ya faru, to a irin wannan yanayin ya kamata ku nemi taimakon likita nan da nan.

Yin amfani da ƙima mai yawa ba ya haifar da raguwa mai yawa a cikin taro na glucose a cikin jini (hypoglycemia), duk da haka, akwai babban yiwuwar iskar shaka mai guba na jinin mai haƙuri tare da lactic acid (lactate acidosis).

A kowane hali, kulawa da gaggawa na likita da magani a asibiti ya zama dole.

Haɗi tare da wasu kwayoyi

Idan an bayar da amfani da miyagun ƙwayoyi, to a wannan yanayin yana da matukar muhimmanci a sanar da likita halartar duk waɗannan magungunan da marasa lafiyar ke amfani da su na ciwon suga har zuwa kwanan nan. Wajibi ne a ambaci ko da magunguna na kan-kan-kudi.

Tare da Sifor 1000 far, akwai damar yiwuwar faduwa cikin sukari na jini a farkon farawar magani, da kuma lokacin da aka kammala sauran magunguna.A wannan lokacin, yakamata a kula da tattara abubuwan glucose a hankali.

Idan akalla ana amfani da ɗayan magungunan masu zuwa, to wannan bai kamata likita yayi watsi da wannan ba:

• corticosteroids (cortisone),
• wasu nau'ikan magungunan da za a iya amfani dasu tare da hawan jini ko ƙarancin aiki na zuciya,
• diuretics ana amfani da su don saukar da hawan jini (diuretics),
• kwayoyi don kawar da ciwon asma (beta tausayi),
• bambancin jami'ai dauke da aidin,
• barasa mai dauke da giya,

Yana da mahimmanci a gargaɗi likitoci game da amfani da irin waɗannan kwayoyi waɗanda zasu iya shafar aikin kodan:

• magunguna don rage hawan jini,
• kwayoyi waɗanda ke rage alamun cututtukan ƙwayar cuta na huhun ciki ko kuma rheumatism (zafi, zazzabi).

Kariya da aminci

Yayin aikin jiyya tare da shirin Siofor 1000, ya zama dole a bi wani tsarin kula da tsarin abinci sannan kuma a kula sosai da yawan abincin da ake samu a jikin carbohydrate. Yana da mahimmanci a ci abinci tare da babban sitaci abun ciki koyaushe:

Idan mai haƙuri yana da tarihin wuce haddi a jiki, to, kuna buƙatar bin ƙashin abincin kalori na musamman. Wannan yakamata ya faru a ƙarƙashin kulawar likita mai halartar.

Don lura da yanayin ciwon sukari, dole ne a kai a kai gwajin jini don sukari.

Siofor 1000 ba zai iya haifar da cutar hypoglycemia ba. Idan anyi amfani da su a lokaci guda tare da wasu magunguna don ciwon sukari, da alama raguwar raguwa cikin matakan glucose na jini na iya ƙaruwa. Muna magana ne game da shirye-shiryen insulin da sulfonylurea.

Yara daga shekaru 10 da matasa

Kafin tsara yadda ake amfani da Siofor 1000 zuwa wannan rukunin na zamani, endocrinologist dole ne ya tabbatar da kasancewar nau'in ciwon sukari na 2 a cikin haƙuri.

Ana aiwatar da warkewa tare da taimakon miyagun ƙwayoyi tare da daidaitawar abincin, kazalika da haɗin haɗin motsa jiki na yau da kullun.

Sakamakon binciken likita na shekara guda da aka sarrafa, sakamakon babban sinadarin Siofor 1000 (metformin hydrochloride) akan ci gaba, haɓaka da balaga na yara ba a kafa shi ba.

A yanzu, babu sauran nazarin da aka gudanar.

Gwajin ya shafi yara ne daga 10 zuwa 12.

Umarni na musamman

Siofor 1000 baya iya shafar ikon tuki yadda yakamata sannan kuma baya tasiri kan ingancin hanyoyin aikin.

A karkashin yanayin amfani da lokaci daya tare da wasu kwayoyi don lura da ciwon sukari mellitus (insulin, repaglinide ko sulfonylurea), ana iya cin zarafin ikon fitar da motoci sakamakon raguwa a cikin yawan kwantar da hankalin glucose na jini.