Atoris: umarnin don amfani, analogues da sake dubawa, farashin a cikin kantin magunguna na Rasha

Atorvastatin shine ɗayan magungunan rage ƙwayar lipid daga rukuni na statins. Babban aikin aiwatarwa shine hana ayyukan HMG-CoA reductase (enzyme wanda ke daukar nauyin sauya HMG-CoA zuwa mevalonic acid). Wannan canjin shine ɗayan matakan farko a sarkar samuwar cholesterol a jiki. Lokacin da aka katse ƙirar Chs, akwai ƙara ƙarfin aiki na masu karɓa na LDL (ƙananan ƙarancin lipoproteins) a cikin hanta da kuma a cikin ƙwayoyin cuta na extrahepatic. Bayan an tattara barbashi na LDL daga masu karɓa, ana cire su daga jini, hakan yana haifar da raguwar haɗuwar LDL-C a cikin jini.

Sakamakon antiatherosclerotic na atorvastatin yana haɓaka sakamakon tasirinsa akan abubuwan haɗin jini da ganuwar jini. Atorvastatin yana hana ayyukan haɗin gwiwar isoprenoids, waɗanda sune abubuwan haɓaka abubuwan haɓaka ƙwayoyin sel na ciki na jijiyoyin jini. Sakamakon sakamako na miyagun ƙwayoyi, akwai haɓakawa game da fadada tasirin endothelium-dogara da jijiyoyin jini, raguwa a cikin taro na LDL-C, Apo-B (apolipoprotein B) da TG (triglycerides), haɓakar taro na HDL-C (babban yawan lipoproteins) da Apo-A (apolipoprotein A).

Ana nuna tasirin warkewa na atorvastatin a cikin raguwar hauhawar jini na jini da kuma aiki na wasu tarin abubuwan farin jini da abubuwan coagulation. Sakamakon haka, hemodynamics yana inganta kuma yanayin tsarin coagulation yana daidaituwa. HMG-CoA reductase inhibitors suma suna shafar metabolism na macrophages, tare da dakatar da kunnawarsu da hana katsewa daga cikin matsanancin bututun da atherosclerotic.

An lura da haɓakar tasirin warkewa, a matsayin mai mulkin, bayan makonni 2 na maganin, ya isa cikin matsakaicin makonni 4 na amfani da Atoris.

Tare da yin amfani da 80 MG na Atoris kowace rana, da yiwuwar rikitowar ischemic (ciki har da mutuwa daga myocardial infarction) an rage shi ta hanyar 16%, kuma haɗarin sake farfadowa saboda angina tare da alamun myocardial shine 26% ƙasa.

Pharmacokinetics

Atorvastatin yana da babban amfani (kusan kashi 80% na kashi ana ɗaukar shi daga ƙwayar gastrointestinal). Matsakaici na sha da ƙwayar plasma a cikin jini yana ƙaruwa gwargwadon kashi. Matsakaicin lokacin isa C_max (matsakaicin maida hankali ne akan abu) - daga 1 zuwa 2 hours. A cikin mata, wannan alamar tana da kashi 20% mafi girma, kuma AUC (yankin da ke ƙarƙashin ɓarna "taro - lokaci") ya ragu 10%. Ta hanyar jinsi da shekaru, bambance-bambance a cikin sigogin kantin magani ba su da mahimmanci kuma ba a buƙatar daidaita sutura.

Tare da giya cirrhosis na hanta T_max (lokaci don kaiwa ga iyakar maida hankali) yakai sau 16 sama da na al'ada. Cin dan kadan yana rage tsawon lokacin da yawan shan atorvastatin (ta hanyar 9% da 25%, bi da bi), yayin da raguwar yawan LDL-C yana kama da na Atoris ba tare da abinci ba.

Atorvastatin yana da ƙananan bioavailability (12%), bioavailability na tsari na aikin hanawa da hanawa HMG-CoA ragewa shine 30% (saboda haɓakar ƙwaƙwalwar ƙwaƙwalwa a cikin mucous membrane na ƙwayar hanji da kuma tasirin "jigon farko" ta hanta).

V_d (distributionarar rarraba) na atorvastatin averages 381 lita. Fiye da kashi 98% na abubuwan suna ɗaure wa garkuwar plasma. Atorvastatin baya shiga katangar-kwakwalwa. Hanyoyin metabolism na faruwa ne a ƙarƙashin rinjayar da keɓaɓɓen CYP3A4 cytochrome P₄₅₀ a hanta. Sakamakon haka, an samar da metabolites na aiki a fannin magunguna (para- da orthohydroxylated metabolites, beta-oxidation kayayyakin), wanda yakai kusan kashi 70% na aikin inhibitory akan rage girman HMG-CoA a cikin tsawon 20-30 hours.

T_1/2 (rabin-rayuwa) na atorvastatin awoyi 14 ne. An keɓance shi musamman da bile (ba a fallasa maimaitawar hanjin-hepatic, tare kuma ba a cire shi). Kusan 46% na atorvastatin an cire ta cikin hanjin ciki, kasa da 2% ta hanta.

Tare da cirrhosis na hanta giya (bisa ga rarrabuwa na Yara-Pugh, aji B), yawan atorvastatin yana ƙaruwa sosai (C_max - kusan sau 16, AUC - kusan sau 11).

Contraindications

• ciki
• lactation
• shekara 18 da haihuwa
• cututtukan hanta (cututtukan hepatitis, cirrhosis, gazawar hanta),
• cutar tsoka
• rashin maganin lactose, karancin lactase, galactose / glucose malabsorption syndrome,
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Dangane da umarnin, yakamata a tsara Atoris tare da taka tsantsan idan akwai cututtukan hanta a cikin tarihi da dogaro na giya.

Umarnin don amfani da Atoris: hanya da sashi

Ana ɗaukar allunan Ator a baki ɗaya a lokaci guda, ba tare da cin abinci ba.

Kafin da lokacin aikin jiyya, ya kamata a bi tsarin rage cin abinci mai ƙoshin abinci mai ƙoshin abinci.

Ba a amfani da Atoris a cikin ilimin yara, an tsara marasa lafiya na 10 10 sau ɗaya a rana don 4 makonni. Idan ba a lura da sakamako mai warkewa ba bayan karatun farko, gwargwadon bayanan lipid, ana kara yawan kullun zuwa kashi 20 zuwa 80 a rana.

Side effects

Amfani da Atoris na iya haifar da sakamako masu illa:

• daga narkewa kamar jini: matsanancin matattara, tashin zuciya, asarar ci, farjin huhun ciki, gurbataccen hanji, amai, hepatitis, jin zafi a yankin na hanji, rashin jin daɗi,
• daga tsarin juyayi: bushewar zuciya, paresthesia, tashin hankali na fargaba da lokacin bacci, jijiyoyin mahaifa, ciwon kai,
• daga musculoskeletal tsarin: cramps, rauni na tsoka, myopathy, ciwon tsoka, myositis,
• daga tsarin zuciya: arrhythmia, palpitations, phlebitis, vasodilation, hawan jini,
• halayen rashin lafiyan: alopecia, urticaria, itching, fitsari a kan fata, edema na Quincke.

Alamu don amfani

Menene taimaka Atoris daga? Adana magungunan a cikin halaye masu zuwa:

• don lura da marasa lafiya tare da firamare (nau'in 2a da 2b) da kuma cudewar hyperlipidemia.
• an nuna kulawa da miyagun ƙwayoyi ga marasa lafiya tare da familialus hyzycholesterolemia tare da karuwa: cholesterol a gaba ɗaya, ƙarancin lipoprotein cholesterol, triglyceride ko apolipoprotein B.

Umarnin don amfani da Atoris, sashi

Ana ɗaukar magani a baka, ba tare da la'akari da abincin ba.

Yankin farawa shine 1 kwamfutar hannu na Atoris 10 MG kowace rana. Dangane da umarnin, sashi na miyagun ƙwayoyi ya bambanta daga 10 MG zuwa 80 MG sau ɗaya a rana, kuma an zaɓi yin la'akari da matakin farko na LDL-C, manufar farfaɗiya da tasirin magani na mutum. Iswararren likitan yana zaban maganin ne, la'akari da sakamakon gwajin da matakin farko na cholesterol.

A farkon farfajiya da / ko yayin karuwa a cikin kashi, yana da mahimmanci don saka idanu cikin abubuwan da ke cikin ƙwayar plasma a kowane mako na 2-4 kuma daidaita sashi gwargwado.

A cikin firamare (heterozygous hereditary da polygenic) hypercholesterolemia (nau'in IIa) da cakuda hyperlipidemia (nau'in IIb), jiyya yana farawa tare da shawarar farko na shawarar, wanda aka haɓaka bayan makonni 4 dangane da amsawar mai haƙuri. Matsakaicin adadin yau da kullun shine 80 MG.

Ga tsofaffi marasa lafiya da marasa lafiya da ke fama da rauni na aiki, ba a buƙatar daidaita sashi.

A cikin marasa lafiya da ke fama da aikin hanta, an wajabta magunguna tare da taka tsantsan dangane da jinkirin kawar da miyagun ƙwayoyi daga jikin mutum.

Side effects

Dangane da umarnin yin amfani da, ƙarar Atoris zai iya haɗuwa da waɗannan sakamako masu illa:

• Daga psyche: rashin jin daɗi, damuwa ta bacci, gami da rashin bacci da yawan bacci.
• Daga tsarin rigakafi: halayen rashin lafiyan, anaphylaxis (gami da girgiza ƙwayar anaphylactic).
• Rashin daidaituwa na metabolism: hyperglycemia, hypoglycemia, karin nauyi, anorexia, ciwon sukari mellitus.
• Daga tsarin haihuwa da gabobin dabbobi masu shaye shaye: lalatawar jima'i, rashin ƙarfi, gynecomastia.
• Daga tsarin juyayi: ciwon kai, paresthesia, dizziness, hypesthesia, dysgeusia, amnesia, neuropathy na gefe.
• Daga tsarin numfashi: cutar huhu na ciki, amai da gudawa, hancin hanci.
• Abun ciki da infestations: nasopharyngitis, cututtukan urinary tract.
• Daga tsarin jini da tsarin lymphatic: thrombocytopenia.
• Daga gefen kwayoyin hangen nesa: hangen nesa mai ruhi, raunin gani.
• Daga tsarin zuciya: bugun jini.
• A wani ɓangaren ɓangaren ji mai jijiya: tinnitus, raunin ji.
• Daga narkewa kamar jijiyoyi: maƙarƙashiya, flatulence, dyspepsia, tashin zuciya, zawo, amai, jin zafi a cikin manya da ƙananan ciki, belching, pancreatitis.
• Daga tsarin hepatobiliary: hepatitis, cholestasis, gazawar hanta.
• A wani ɓangaren fata da ƙwayoyin subcutaneous: urticaria, fatar fata, itching, alopecia, angioedema, bullous dermatitis, ciki har da exudative erythema, Stevens-Johnson syndrome, mai guba da ƙwayoyin cutar necrolysis, guba da jijiyoyin jiki.
• Daga tsarin musculoskeletal: myalgia, arthralgia, jin zafi a cikin wata gabar jiki, kasalar tsoka, kumburi tare, ciwon baya, ciwon wuya, rauni na tsoka, myopathy, myositis, rhabdomyolysis, tendonopathy (wani lokacin rikicewar da jijiyoyin wuya).
• Rashin rikice-rikice na yau da kullun: malaise, asthenia, ciwon kirji, yanki na ciki, gajiya, zazzabi.

Contraindications

Atoris yana cikin abubuwan da ke tafe:

• mutum mai haƙuri zuwa ga abubuwan da ke tattare da kwayoyi,
• galactosemia,
• malabsorption na glucose galactose,
• karancin maganin lactose,
• m koda cuta,
• tsoka tsoka,
• ciki
• nono
• shekaru har zuwa shekaru 10.

Ya kamata a dauki hankali tare da shan giya, cutar hanta. Wannan rukunin ya kuma ƙunshi mutanen da ayyukan sana'arsu ke da alaƙa da tuki motoci da wasu keɓaɓɓun hanyoyin.

Yawan abin sama da ya kamata

Game da yawan abin sama da ya kamata, ya kamata a bayyanar da cututtukan da suka kamata kuma a tallafa musu. Wajibi ne don sarrafa aikin hanta da aikin CPK a cikin jini. Hemodialysis ba shi da tasiri. Babu takamaiman maganin rigakafi.

Ana sayar da magungunan Atoris, farashi a cikin kantin magani

Idan ya cancanta, za'a iya maye gurbin Atoris tare da analog na abu mai aiki - waɗannan magunguna ne:

Lokacin zabar analogues, yana da mahimmanci a fahimci cewa umarnin don amfani da Atoris, farashin da sake dubawa na kwayoyi tare da tasirin irin wannan ba su amfani. Yana da mahimmanci don samun shawarar likita kuma kada kuyi canjin magani mai yanci.

Farashi a cikin magunguna na Rasha: Allunan Atoris 10 MG 30 inji mai kwakwalwa. - daga 337 zuwa 394 rubles, 20 mg 30pcs - daga 474 zuwa 503 rubles.

Adana a zazzabi da bai wuce 25 ° C. Rayuwar shelf shine shekaru 2. A cikin kantin magunguna, ana siyar da shi ta hanyar sayan magani.

Akwai ra'ayoyi daban-daban game da Atoris, kamar yadda mutane da yawa suka ce babban farashin maganin yana barata ta hanyar inganci da haƙuri mai kyau. An lura cewa yayin aikin jiyya, yakamata a bi umarnin likita game da abinci da aikin jiki, kuma lokacin zaba da daidaita sashi, yakamata ayi la'akari da yawaitar lipoproteins mai yawa. A cewar wasu masu amfani, miyagun ƙwayoyi ba shi da tasirin warkewa da ta dace kuma yana da haƙuri da haƙuri, yana haifar da mummunan sakamako.

Sake dubawa 5 na “Atoris”

Mahaifina ya kwashe shekaru biyu yana cin atoris ba tare da hutu ba bayan wani bugun zuciya - ba shi da wata illa, komai na mutum ne

Magungunan yana da ban mamaki, tare da sakamako kaɗan. My cholesterol ya kasance 6.2-6.7.
Ina sha Atoris a kai a kai tare da sashi na 20 mg. Yanzu cholesterol ya tabbata daga 3.5 zuwa 3.9. Ba na bin abinci

Kyakkyawan mataimaki a cikin kawar da cutarwa, koda ba tare da cutarwa ba kuma babu inda, amma ya kamata a kula da cholesterol.

Ina sha makonni biyu Atoris ko yana yiwuwa a ɗauki hutu.

An umurce ni da miyagun ƙwayoyi saboda ED. Na karba kullun, zan tafi in dauki gwaji nan bada jimawa ba. Don tsalle kanta, Ina ɗaukar Sildenafil-SZ.

Menene taimaka wa Allunan Allunan? - alamomi

Atoris an nuna shi don yawancin cututtuka na tsarin jijiyoyin jini da haɗarin da ke hade:

• basantankara,
• bashin,
• dyslipidemia, don rage hadarin infarction myocardial,
• m bayyananniyar cutar ischemic zuciya,
• bugun jini
• abin da ya faru na angina pectoris.

Hakanan ana amfani da maganin yadda yakamata a cikin hadaddun fargaba idan aka samu ci gaban masu ciwon suga, hyperlipidemia.

Atoris analogues, jerin magunguna

Atoris analogues sune magunguna masu zuwa:

Mahimmanci - umarnin don amfani da Atoris, farashi da sake dubawa ba su shafi analogues ba kuma ba za a iya amfani da shi azaman jagora don amfani da kwayoyi irin wannan abin da ke kama ko tasiri ba. Dukkanin alƙawarin da ya kamata ya kamata likita ne ya tsara su. Lokacin sauya Atoris tare da analog, yana da mahimmanci a nemi ƙwararrun likitanci, wataƙila ku canza hanya na aikin jiyya, sashi, da sauransu. Kada ku sami magani na kai!

Abubuwan da likitocin suka yi game da amfani da Atoris suna da inganci a zahiri - marasa lafiya sun lura da ci gaba a cikin yanayin lafiyar su na dogon lokaci, koda bayan an dakatar da maganin. Magungunan yana cikin magungunan rage ƙwayar lipid kuma ya kamata a ɗauka kamar yadda likita ya umurce shi.

Formaddamar da tsari da abun da ke ciki

Atoris an samar dashi a cikin Slovenia a cikin nau'ikan allunan tare da harsashi wanda dole ne a sha shi a baki. Dos na Atoris 10, 20, 30 da 40 mg sune fari da fari (sifofin kwalliyar alama ce ta kwastomomi na 60 da 80 MG, waɗanda basa samarwa a kasuwar Rasha).

A cikin fakiti 30 ko 90 allurai, kazalika da umarnin umarnin aikin da aka yarda.

Atorvastatin (sunan ƙasa - Atorvastatinum) shine babban sinadaran aiki a cikin magungunan Atoris (INN a Latin - Atoris). Dukkanin nau'ikan tasirin magunguna suna samar da tsarin aikin Atorvastatin a cikin magunguna daban-daban - 10, 20, 30, 40 mg (allurai na Atoris 60 da 80 mg suna rajista a wasu ƙasashe).

Halayen magunguna

Atoris suna ba da gudummawa ga samar da irin wannan tasirin magungunan:

• Yana taimakawa rage danko na jini, yana aiwatar da tsari na coagulation na jini.
• Taimakawa yiwuwar fashewar alluran atherosclerotic.
• Wersaukar ƙananan ƙwayoyi na rashin ƙarfi na ƙananan kwayoyi, triglycerides.
• Theara yawan abun ciki na ƙwayar ƙwayar lipoprotein mai yawa.
• Yana da tasirin anti-atherosclerotic - yana da kyau yana tasiri ganuwar tasoshin jini.

Sakamakon warkewar Atoris yana tasowa bayan makonni 2 na cin abinci na yau da kullun Allunan, matsakaicin sakamako na miyagun ƙwayoyi - bayan wata 1.

Me aka gindaya Atoris?

Magungunan yana taimakawa a cikin halaye masu zuwa:

Alamu don amfani da Atoris sun bambanta dan kadan dangane da abun ciki na allunan atorvastatin.

Atoris 10 mg da Atoris 20 mg:

• babban hyperlipidemia na IIa da IIb bisa ga rarrabuwa na Fredrickson, gami da polygenic hypercholesterolemia, cakuda hyperlipidemia, heterozygous familial hypercholesterolemia, don rage jimlar cholesterol, apolipoprotein B, LDL cholesterol, triglycerides a cikin jini,
• iyali na hyzycholesterolemia, don rage jimlar cholesterol, apolipoprotein B, LDL cholesterol, a matsayin ƙari ga ilimin abinci da sauran hanyoyin magani marasa magani.

Atoris 30, 40, 60, 80 MG:

• primary hypercholesterolemia (ba dangi da dan heterozygous irin II hypercholesterolemia bisa ga rarrabuwa na Fredrickson,
• cakuda (hade) hyperlipidemia na nau'ikan IIa da IIb bisa ga rarrabuwa da Fredrickson,
• nau'in dysbetalipoproteinemia na III bisa ga rarrabuwa na Fredrickson (a ƙari ga aikin abinci),
• Abinci-yana iya magance cututtukan iyali na nau'in cutar hawan jini na jini na III wanda ya danganta da Fredrickon,
• familial homozygous hypercholesterolemia, a matsayin ƙari ga ilimin abinci da sauran hanyoyin magani marasa magani.

An tsara allurai na Atoris:

• don manufar rigakafin farko na cututtukan zuciya a cikin marasa lafiya ba tare da bayyanar cututtuka na IHD ba, amma tare da yiwuwar ci gabanta saboda abubuwan haɗarin da ake ciki, ciki har da shekaru bayan shekaru 55, hauhawar jini, dogarawar nicotine, ciwon sukari mellitus, ƙarancin plasma HDL cholesterol, ƙaddarar jini. ,
• tare da manufar rigakafin sakandare na cututtukan zuciya na jijiyoyin jini a cikin marasa lafiya da ke fama da cututtukan zuciya na zuciya, don rage rikice-rikice, ciki har da infarction na myocardial, mace-mace, bugun jini, sake komawa asibiti da ke hade da angina pectoris da buƙatar farfadowa.

Umarnin likita don amfani

Lokacin ɗaukar Atoris, mai haƙuri dole ne ya bi ka'idodin ka'idodin rage rage yawan abincin lipid a duk tsawon lokacin maganin.

An shawarci marasa lafiya na Obese game da masu zuwa: kafin fara amfani da Atoris, mutum ya kamata yayi ƙoƙarin daidaita matakan ƙwayar cholesterol ta hanyar haɗuwa da matsakaicin aiki na jiki da kuma lura da dalilin cutar.

Ina ɗaukar Atoris a ciki, ba tare da la'akari da cin abinci ba. Maganin farko shine 10 MG.

Kamar yadda ya cancanta, ana iya ƙara yawan zuwa 80 MG. Iswararren likitan yana zaban maganin ne, la'akari da sakamakon gwajin da matakin farko na cholesterol.

Ana ba da shawarar kashi ɗaya na yau da kullun na miyagun ƙwayoyi, zai fi dacewa a lokaci guda. Bai kamata a daidaita sashi ba kafin watan 1 bayan fara amfani da maganin.

A lokacin jiyya, wajibi ne don saka idanu akai-akai matakin lipids a cikin jini na jini. Ya kamata a aiwatar da hanyar a kalla sau ɗaya a kowane mako na 2-4.

Gyara daidaitawa na marasa lafiya na tsofaffi kungiyoyin ba a buƙata.

Ana amfani da Atoris azaman taimako na jiyya na aiki tare tare da sauran hanyoyin maganin (plasmapheresis). Hakanan za'a iya amfani da miyagun ƙwayoyi azaman babban bangaren maganin idan har sauran hanyoyin magani da magunguna basu da tasiri na warkewa.

Yi amfani da lokacin daukar ciki da lactation

Atoris yana contraindicated a cikin ciki da kuma lactating uwaye.

An tsara magungunan ga mata masu haihuwa kawai idan yuwuwar samun juna biyu ya ragu, kuma a sanar da mara lafiyar game da yiwuwar haɗarin tayin. Ya kamata matan da suka isa haihuwa suyi amfani da isassun hanyoyin rigakafi yayin magani. Idan mace tana shirin daukar ciki, to ya kamata ta daina shan Atoris aƙalla wata guda kafin shirinta na ɗaukar ciki.

Idan ya cancanta, nadin Atoris ya kamata ya yanke shawara game da dakatar da shayarwa.

Yadda ake ɗaukar yara?

Ba a gudanar da nazarin ingancin Atoris da amincin amfaninsa a cikin yara ba, wanda daga kwamfyutocin Atoris suna haɗu har zuwa shekara 18.

1. Anvistat
2. Atocord
3. Atomax
4. Atorvastatin
5. Allium atorvastatin,
6. Atorvox
7. Vazator
8. Lipona
9. Lipoford
10. Liprimar
11. Kaya Yanar,
12. TG-tor
13. Torvazin
14. Thorvacard
15. Tulip

Lokacin zabar analogues, dole ne a tuna cewa umarnin don amfani da Atoris, farashin da sake dubawa na kwayoyi irin wannan ba su amfani ba. Sauya maganin yana halatta ne kawai bayan shawarar likita.

Liprimar ko Atoris - Wanne ya fi kyau?

Kamar yadda yake a cikin yanayin tare da Torvacard, Liprimar alama ce ta Atoris, shine, ya ƙunshi abu ɗaya a matsayin atorvastatin a matsayin kayan aiki mai aiki. Dukansu magunguna suna da alamomi iri ɗaya, fasalin amfani, contraindications, sakamako masu illa, da sauransu.

Dosages na Liprimar maimaita yawan Atoris banda allunan 30 MG. Kamfanin kamfanin Liprimara - Pfizer (Ireland), wanda a cikin sa yayi magana game da ingancin samfurin.

Yana da mahimmanci a sani cewa Liprimar shine asalin magungunan atorvastatin, kuma duk sauran, ciki har da Atoris, asalinsa ne.

Torvakard ko Atoris - Wanne ya fi kyau?

Ya kamata a sani cewa duka magungunan suna dauke da atorvastatin a matsayin sashi mai aiki, sabili da haka suna da tasirin magunguna iri ɗaya. Atoris an samar dashi ne daga Krka (Slovenia), kuma Torvacard ta Zentiva (Czech Republic).

Dukkanin kamfanonin masana'antar sun shahara sosai kuma suna da suna mai kyau, wanda ya sa waɗannan magunguna kusan ba su da ma'ana. Bambanci kawai tsakanin Torvacard shine sashi na allunansa, wanda shine matsakaicin 40 mg, yayin da wasu yanayin cututtukan cuta ke buƙatar allurai na atorvastatin 80 MG, wanda na iya haifar da wasu damuwa ga shan allunan.

Umarni na musamman

Kafin farawa da maganin Atoris, ya kamata a tsara mai haƙuri ta hanyar daidaitaccen tsarin abinci, wanda dole ne ya bi yayin duk lokacin kulawa.

Lokacin amfani Atoris, haɓaka aikin hepatic transaminase za'a iya lura. Wannan ƙaruwa yawanci ƙarami ne kuma bashi da mahimmancin asibiti. Koyaya, ya zama dole don saka idanu kan alamomin ayyukan hanta kafin magani, makonni 6 da makonni 12 bayan farawar magunguna da kuma bayan an kara yawan maganin. Ya kamata a dakatar da jiyya tare da karuwa a AST da ALT fiye da sau 3 dangane da VGN.

Atorvastatin na iya haifar da karuwa a cikin ayyukan CPK da aminotransferases.

Yakamata a gargadi marassa lafiya cewa yakamata su nemi likita kai tsaye idan zafin da ba a bayyana ba ko rauni na tsoka ya faru. Musamman idan waɗannan alamu suna tare da zazzabi da zazzabi.

Tare da jiyya tare da Atoris, haɓakar ciwon kai na iya yiwuwa, wanda a wasu lokuta yana haɗuwa da rhabdomyolysis, wanda ke haifar da gazawar cutar koda. Hadarin wannan rikitarwa yana ƙaruwa yayin ɗauka ɗaya ko fiye na kwayoyi masu zuwa tare da Atoris: fibrates, nicotinic acid, cyclosporine, nefazodone, wasu ƙwayoyin rigakafi, antifungals na Azole, da masu hana ƙwayoyin cutar ta HIV.

A cikin bayyanar cututtukan cututtukan cututtukan zuciya, ana bada shawara cewa shawarar plasma na CPK ta ƙaddara. Tare da ƙaruwa sau 10 a cikin aikin VGN na KFK, ya kamata a dakatar da jiyya tare da Atoris.

Akwai rahotanni na ci gaban atciic fasciitis tare da yin amfani da atorvastatin, duk da haka, haɗi tare da amfani da miyagun ƙwayoyi yana yiwuwa, amma har yanzu ba a tabbatar da hakan ba, ba a san etiology ba.

Yawan abin sama da ya kamata

Babu wata shaida game da yawan shan ruwa.

Game da yawan abin sama da ya kamata, ana nuna taimako da warkewar cutar siga. Kulawa da kiyaye mahimman ayyuka na jiki, rigakafin ƙarin sha na Atoris (ɗaukar kwayoyi tare da tasirin laxative ko gawayi, ƙwayar ciki), sa ido kan aikin hanta da kuma aikin creatine phosphokinase a cikin ƙwayoyin jini ana buƙatar.

Hemodialysis ba shi da tasiri. Babu takamaiman maganin rigakafi.

Hulɗa da ƙwayoyi

Tare da yin amfani da Atoris (10 MG) tare da diltiazem (fiye da 200 MG), ana iya lura da ƙaruwa cikin haɗuwar Atoris a cikin jini na jini.

Hadarin rikitarwa yana ƙaruwa lokacin da aka yi amfani da Atoris a cikin haɗin gwiwa tare da fibrates, acid nicotinic, maganin rigakafi, wakilai na antifungal.

Tasirin Atoris yana raguwa tare da amfani da lokaci ɗaya na Rifampicin da Phenytoin.

Tare da yin amfani da lokaci ɗaya tare da shirye-shiryen antacid, wanda ya haɗa da aluminium da magnesium, ana lura da raguwa a cikin haɗakar Atoris a cikin jini na jini.

Shan Atoris tare da ruwan 'ya'yan itace na innabi zai iya kara maida hankali kan miyagun ƙwayoyi a cikin jini na jini. Marasa lafiya waɗanda suka ɗauki Atoris ya kamata su tuna cewa shan ruwan 'ya'yan innabi a cikin girma fiye da 1 lita kowace rana ba a yarda da su ba.

Menene sake dubawa suke magana akai?

Akwai ra'ayoyi daban-daban game da Atoris, kamar yadda mutane da yawa suka ce babban farashin maganin yana barata ta hanyar inganci da haƙuri mai kyau. An lura cewa yayin aikin jiyya, yakamata a bi umarnin likita game da abinci da aikin jiki, kuma lokacin zaba da daidaita sashi, yakamata ayi la'akari da yawaitar lipoproteins mai yawa.

A cewar wasu masu amfani, miyagun ƙwayoyi ba shi da tasirin warkewa da ta dace kuma yana da haƙuri da haƙuri, yana haifar da mummunan sakamako.

Ra'ayoyin Atoris

Akwai ra'ayoyi daban-daban na Atoris. Dayawa sun lura cewa babban farashin maganin yana barata ta hanyar inganci da kyawun haƙuri. An lura cewa yayin aikin jiyya, yakamata a bi umarnin likita game da abinci da aikin jiki, kuma lokacin zaba da daidaita sashi, yakamata ayi la'akari da yawaitar lipoproteins mai yawa. A cewar wasu masu amfani, Atoris ba shi da tasirin warkewar da ake so kuma yana da haƙuri da haƙuri, yana haifar da mummunan sakamako.

Ta yaya miyagun ƙwayoyi ke aiki?

A kan tushen abu mai aiki na atorvastatin, an sanya magungunan Atoris. Menene taimaka? Yana rage yawan yawan lipids a cikin jini. Saboda aikin atorvastatin, ayyukan GMA reductase yana raguwa kuma an hana aikin haɗin cholesterol. Quantimar adadin ƙarshen ƙarshe a cikin jini yana raguwa sosai saboda karuwar adadin masu karɓa akan ƙwayoyin hanta da haɓaka da ɗaure na lipoproteins.

"Atoris" kuma yana da tasirin antisclerotic akan tasoshin jini. Abubuwa masu aiki suna hana samar da isoprenoids. Vasodilation shima yana inganta. A matsayinka na mai mulkin, ana iya samun sakamako na farko bayan kammala makonni biyu. Kuma bayan makonni huɗu, matsakaicin sakamako yana faruwa.

Kusan 80% na abu mai aiki yana ɗaukar ta hanyar narkewar abinci. Bayan 2 hours, maida hankali ne kan atorvastatin a cikin jiki ya kai matsayin mafi girma. Yana da mahimmanci a lura cewa a cikin mata wannan adadi ya kai kashi 20% sama da na maza. Aikin hanawa yakai tsawon awanni 30. Amma kawar da miyagun ƙwayoyi yana farawa bayan sa'o'i 14. Babban rabo aka share a cikin bile. Sauran kashi 40-46% suna barin jiki ta cikin hanji da fitsari.

A cikin lambobin da yawa, likitoci sun yanke shawara don ba da magani kamar Atoris. Alamu don amfanin sa kamar haka:

• na farko hypercholesterolemia,
• Cakuda maganin cuta,
• familiya hypercholesterolemia,
• dysbetalipoproteinemia,
• cututtukan zuciya da cututtukan jijiyoyin jiki wanda ke haifar da dyslipidemia,
• rigakafin cututtukan zuciya da jijiyoyin jini, ciwon zuciya da angina pectoris,
• na biyu rigakafin sakamakon da ba a ke so ba na cutar zuciya.

Babban contraindications

Ba duk masu haƙuri za su iya amfani da allunan Atoris ba. Contraindications sune kamar haka:

• cututtukan hanta na yau da kullun waɗanda suke a cikin matakin ɓarna,
• giya hepatitis
• gazawar hanta
• ciki da shayarwa,
• cirrhosis na hanta
• increasedarin hepatic transaminases,
• ji na ƙwarai game da aiki bangaren ko rashin lafiyan dauki da shi,
• tsoka tsarin cututtuka
• shekaru zuwa shekaru 18
• rashin haƙuri a cikin lactase ko rashi,
• m koda cuta
• galactose malabsorption.

Tare da tsananin taka tsantsan, an wajabta magunguna ga marasa lafiya da irin waɗannan cututtukan:

• barasa
• bayyana damuwa a cikin ma'aunin electrolytes,
• matsaloli na rayuwa
• cututtukan endocrine
• karancin jini
• mummunan cututtuka
• amo mai amo
• manyan hanyoyin tiyata,
• mummunan raunin da ya faru.

Yadda ake shan magani

Don cimma tasirin sanarwa, yana da muhimmanci a ɗauka "Atoris" daidai. Umarni ya ƙunshi irin wannan bayanin:

• Bayan 'yan kwanaki kafin a fara shan miyagun ƙwayoyi, ya kamata a tura mai haƙuri zuwa abincin, wanda ke nuna raguwar adadin ƙwayoyin lipids. Ya kamata a bi wannan abincin a duk tsawon lokacin magani.
• Ana ɗaukar allunan Ator ba tare da la'akari da tsarin abinci ba.
• Dogaro da tattarawar farko na LDL-C wanda aka ƙaddara ta hanyar sakamakon binciken, ana iya tsara 10-80 MG na miyagun ƙwayoyi kowace rana. Ana amfani da wannan adadin a lokaci ɗaya.
• An ba da shawarar yin amfani da miyagun ƙwayoyi "Atoris" kowace rana a lokaci guda.
• Canja sashi ba da shawarar a farkon makonni 4 bayan farkon maganin. Bayan wannan lokaci ne kawai zamu iya kimanta tasirin warkewa da daidaita jiyya.

Lokacin Adadin

Daga marasa lafiya zaku iya jin ra'ayi iri iri game da tsawon lokacin da za'a ɗauki Atoris. Masana sun ce idan har akwai barazanar kamuwa da ciwon zuciya, to yakamata a sha maganin a kan wani ci gaba (wato, duk rayuwa). A lokaci guda, ba a ba da shawarar ɗaukar kowane hutu ba, saboda magungunan tushen atorvastatin ba su da niyyar gudanarwa ta hanya. Ko da suna da tasirin sakamako masu illa ga lafiyar jiki, dole ne ka zabi tsakanin dadi da kwanciyar hankali na rayuwa. Rage sashi ko cirewa zai yuwu ne kawai idan cutukan da suka zama marasa iya jurewa.

Wasu marasa lafiya suna yin wasan kwaikwayo na mai son motsa jiki kuma suna ɗaukar magunguna na tushen atorvastatin kowace rana. Ba za a iya kiran wannan abin da komai ba sai “zane-zanen mutane.” Idan likita ya shawarce ku da irin wannan makirci, yana da kyau shakkar cancantarsa. Babu nazarin karatun asibiti wanda zai tabbatar da ingancin irin wannan tsarin gudanar da magani ba a gudanar da shi ba.

Maganin Atoris: sakamako masu illa

Duk da duk fa'idodin maganin da ake tambaya, a wasu halaye akwai raguwa cikin walwala. Sabili da haka, a karkashin kulawa ta kusa da likita, ana bada shawara a dauki Atoris. Abubuwan da ke haifar da sakamako na iya zama kamar haka:

• Wani lokacin tsarin mai juyayi yana amsa shan wannan magani tare da rashin bacci da tsananin wahala. Asthenia, ciwon kai da kuma rashin kwanciyar hankali shima zai yiwu. Da ƙarancin nutsuwa, rashi ƙwaƙwalwa, rashin damuwa da fitsari na faruwa.
• Hakanan ana iya faruwa daga gabobin ciki. Tinnitus da rasa ji na ji, bushewar idanu, karkatacciyar tsinkaye game da dandano, ko kuma wani lokacin rasa hasarar ɗanɗano.
• Atoris na iya haifar da matsaloli tare da tsarin zuciya. Nazarin haƙuri ya ƙunshi bayani game da ciwon kirji, bugun zuciya, hawan jini, arrhythmias, angina pectoris. Cutar sankara tana iya yiwuwa.
• Yayin shan magungunan, tsarin numfashi ya zama mafi rauni. Magungunan na iya tsokanar cutar huhu, rhinitis, harin asma. Hakanan ana iya iya zama bakin hanci.
• Yawancin sakamako masu illa suna lura daga tsarin narkewa. Marasa lafiya sau da yawa suna ba da rahoton ƙwannafi da jin zafi a ciki, tashin zuciya, zawo, ƙwanƙwasa. Magunguna na iya haifar da ƙaruwa a cikin ci ko rashinsa. Wataƙila samuwar ulcers, gastritis, pancreatitis. A cikin mafi yawan lokuta, an lura da zubar jini na hanji.
• Tare da tsawaita amfani da miyagun ƙwayoyi a cikin tambaya, matsaloli tare da tsarin musculoskeletal na iya faruwa. Mafi sau da yawa, marasa lafiya suna bayar da rahoton cramps, myositis, amosanin gabbai da hauhawar tsoka.
• Daga tsarin jijiyoyin jiki, haɗarin cututtukan cututtuka, matsaloli tare da urination (jinkirta ko enuresis), nephritis, lalata jima'i, zubar jini na farji.
• Marasa lafiya suna shan allunan Atoris na dogon lokaci suna lura da asarar gashi da kuma wuce kima. Wataƙila mummunan tasirin da ke tattare da ƙoshin fata, rashes, urticaria.Da wuya a gano cutar kumburin fuska.
• Yayinda kake shan maganin, ƙara ƙarancin nauyin jikin yana yiwuwa.

Magani "Atoris": analogues

Magunguna a cikin tambaya yana da yawancin musanyawa waɗanda suke yin aiki iri ɗaya a jiki. Dogaro da masana'anta, farashin na iya zama mafi girma ko ƙasa da Atoris. Analogs sune kamar haka:

• "Torvacard" - kamar maganin da ake tambaya, ya ƙunshi abu mai aiki kamar atorvastatin. Duk da cewa kusan analog ne cikakke, tasirin warkewar aikinta ya ɗanɗaɗa. Amma zai kusan kusan sau uku mafi tsada fiye da kayan aikin da ake tambaya.
• Liprimar cikakke ne analog na Atoris. Wannan za a iya gani ba wai kawai a cikin kayan sunadarai ba, har ma a cikin alamun, contraindications da tasirin asibiti.
• "Sinator" - shima cikakkiyar analog ne na maganin da ake tambaya. Tunda babu wani binciken da aka gudanar game da aminci da tasirin magani ga yara, an wajabta shi ne kawai ga manya.
• "Rosuvastatin" shine magungunan ƙarni na ƙarshe. Yana da inganci fiye da atorvastatin, kuma yana da effectsarancin sakamako masu illa.
• “Torvakard” kusan cikakkiyar magana ce ta “Atoris”. Wannan ba za a faɗi wane irin kwayoyi ne mafi kyau ba. Yana da mahimmanci cewa duka kamfanonin samar da magunguna guda biyu suna samar da su.
• "Simvastitatin" magani ne na mutanen da suka gabata. A matsayinka na mai mulki, likitoci kusan basa yin maganin sa, tunda yana da ƙarancin aiki fiye da Atoris kuma baya haɗuwa sosai da sauran magunguna. M, ana ɗaukar shi ta hanyar mutanen da suka dade suna bi, da kuma masu amfani da kwayoyi ta halitta.

Cikakken ra'ayi

Nazarin marasa lafiya zai taimaka wajen kimanta tasirin magungunan Atoris. Daga cikinsu zaku iya jin waɗannan maganganu masu kyau:

• Kimanin wata daya bayan fara maganin, ana rage yawan kwalagin ko kuma inganta shi,
• babu wasu sakamako masu illa da aka ambata,
• in mun gwada da araha idan aka kwatanta da wasu analogues,
• miyagun ƙwayoyi ne ke samarwa ta hanyar kamfani mai daraja, sabili da haka kuna iya tabbata cewa ana sarrafa sarrafawa, kuma ingancin ya cika ka'idodin Turai.

Nazarin ra'ayoyi mara kyau

Saƙon magani na likita kawai zai yiwu a ɗauki maganin "Atoris". Yin bita da haƙuri zai taimaka wajen fahimtar mummunan yanayin aikin jiyya tare da wannan kayan aiki:

• Bayan shan magunguna, tsokoki na sun ji ciwo ƙwarai,
• bayan dakatar da maganin, cholesterol yakan tashi da sauri (ƙari, mai nuna alama ya fi yadda ake jiyya kafin magani),
• fatar fata ta bayyana,
• gajiya yana ƙaruwa sosai yayin shan ƙwayoyi,
• ana buƙatar kulawa da likita koyaushe.

Kammalawa

Atoris shine ɗayan magunguna da yawa dangane da atorvastatin wanda aka tsara don rage ƙwayar jini. Haka kuma, yana aiki akan adon abubuwa masu cutarwa waɗanda suka yi nasarar tarawa a baya. Duk sabbin kwayoyi na wannan rukunin suna bayyana a kasuwa, suna yin gasa da juna. A kowane hali, likita ya kamata ya zaɓi maganin.

Allunan Allunan, umarnin don amfani (Hanyar da sashi)

Umarnin don amfani da Atoris yana ba da shawarar cewa kafin farawa tare da amfani da shi, canja wurin mai haƙuri zuwa abinciwanda zai bayar rage lipid a cikin jini. Ya kamata a bi tsarin abincin a tsawon lokacin magani. Kafin ka fara shan Atoris, yakamata kayi kokarin samun iko hypercholesterolemiata hanyar aikatawa motsa jiki da asarar nauyi a cikin masu fama da kiba har ma ta hanyar magani cutar cuta.

Ana ɗaukar allunan Ator a baki (a baka), bayan abinci ko a kan komai a ciki. An ba da shawarar farawa tare da maganin guda ɗaya na yau da kullum na 10 MG, bayan wannan, dangane da tasiri na ƙwayar farko kuma idan ya zama dole a ƙara shi, an ƙulla mafi girma kashi - 20 MG, 40 MG, da sauransu har zuwa 80 MG. Magungunan Atoris, a cikin kowane matakin, ana ɗaukar sau ɗaya a rana, a lokaci guda na rana, dacewa ga mara haƙuri. Ana lura da tasirin warkewa bayan yin amfani da makonni biyu na miyagun ƙwayoyi, tare da haɓaka mafi girman tasirinsa bayan makonni huɗu. A wannan batun, gyaran Atoris ana aiwatar dashi ne bawai a farkon satin da ya fara ɗauka ba, la’akari da matakin ingancin maganin da ya gabata. Matsakaicin yiwuwar maganin yau da kullun na Atoris shine 80 MG.

Don warkewa hadewar hyperlipidemia Nau'in IIb da na farko(polygenicda heterozygous na gado) hypercholesterolemiaNau'in IIa, suna ba da shawarar shan Atoris a kashi 10 MG, tare da karuwa a cikin kashi bayan sati huɗu, bisa la onakari da tasiri na farkon kashi da hankalin mutum kowane haƙuri.

Don neman magani maganin hyzycholesterolemia na gado, ya danganta da tsananin bayyanarsa, ana gudanar da zaɓi na allurai na farko daban-daban, kamar yadda yake da sauran nau'ikan. basir.

A cikin mafi yawan marasa lafiya tare da maganin hyzycholesterolemia na gado ingantaccen tasiri na Atoris an lura dashi a cikin kashi ɗaya na yau da kullun na 80 MG.

An tsara Atoris a matsayin ƙarin magani zuwa wasu hanyoyin maganin (misali, plasmapheresis) ko kuma babban maganin, idan ba shi yiwuwa a gudanar da magani tare da sauran hanyoyin.

Marasa lafiya tare da cututtukan koda da kuma a cikin tsufa basu buƙatar daidaita sashi na magani.

Marasa lafiya tare da cututtukan hanta nadin Atoris yana yiwuwa tare da taka tsantsan, tunda a wannan yanayin akwai raguwar kawarwa atorvastatin daga jiki. Ana gudanar da aikin tiyata a ƙarƙashin ikon gwaje-gwaje da alamu na asibiti kuma a cikin yanayin karuwa mai mahimmanci matakan transaminase tare da raguwar kashi ko tare da cikakken cire maganin.

Haɗa kai

Amfani na lokaci daya atorvastatintare da maganin rigakafi (Clarithromycin, Amaryaw, Quinupristine / dalfopristine), NefazodonKwayar cutar kwayar cutar HIVRitonavir, Indinavir), magungunan antifungal (Ketoconazole, Itraconazole, Fluconazole) ko Sankarinina iya haifar da hauhawar matakan jini atorvastatinkuma sanadi myopathiestare da kara rhabdomyolysisda ci gaba na gazawar.

Amfani da Atoris tare da nicotinic acid da zaren wutaa cikin rage rage kiba (sama da 1 g / day), haka kuma 40 mg atorvastatinda 240 MG Diltiazemayana kuma haifar da karuwa a cikin jini atorvastatin.

Hada kai na Atoris tare da Rifampicinda Phenytoinlowers da tasiri.

Antacids(dakatarwa aluminum hydroxides da magnesium) runtse abubuwan atorvastatina cikin jini.

Hada Atoris da ColestipolHar ila yau, lowers taro atorvastatina cikin jini da kashi 25%, amma yana da tasirin warkewa mafi girma, idan aka kwatanta da Atoris kaɗai.

Saboda haɓakar haɓakar ƙananan matakan steroid endogenous hormone, yin taka tsantsan wajibi ne yayin da aka tsara Atoris tare da kwayoyi waɗanda ke rage matakin steroid endogenous steroid (gami da ƙari) Spironolactone, Ketoconazole, Cimetidine).

Marasa lafiya a lokaci guda suna karbar Atoris a kashi 80 na mg da Digoxinyakamata ya kasance karkashin kulawa na yau da kullun, saboda wannan haɗin yana haifar da karuwa a cikin taro Digoxin, kusan kashi 20%.

Atorvastatinna iya inganta sha maganin hana haihuwa (Ethinyl estradiol, Northindrone) da, gwargwadon haka, maida hankali ne a cikin plasma, wanda na iya buƙatar sake tsara wata rigakafin.

Haduwar gaba daya Atoris da Warfarin, a farkon amfani, na iya inganta tasirin ƙarshen dangane da haɗuwa da jini (raguwa cikin PV). Wannan sakamako yana raguwa bayan kwanaki 15 na haɗin gwiwa.

Atorvastatinba shi da wani tasiri mai tasiri a asibiti Terfenadine da Karin.

Amincewar amfani da 10 MG Amlodipineda kuma 80 MG atorvastatinba ya haifar da canji a cikin pharmacokinetics na karshen a cikin ma'auni.

An bayyana yanayin kirkirar. rhabdomyolysisa cikin marasa lafiya waɗanda lokaci guda suka ɗauki Atoris da fusidic acid.

Aikace-aikacen Atoris tare da isrogenda maganin rigakafin jini, a cikin tsarin canzawar motsa jiki, bai bayyana alamun hulɗa mara amfani ba.

Ruwan innabi, a cikin adadin 1,2 lita a kowace rana, yayin jiyya tare da Atoris na iya haifar da karuwa a cikin ƙwayar plasma na miyagun ƙwayoyi, sabili da haka, yawan amfani da shi ya kamata ya iyakance.

Analogs na Atoris

Ana amfani da magungunan Atoris da kwayoyi kusa da shi a cikin aikin aikin su. Mafi yawan maganganun analogues sune:

Farashin analogues ya bambanta sosai kuma ya dogara da masana'anta, yawan abubuwan da ke aiki mai aiki da adadin allunan. Don haka kwayoyin hana daukar ciki Simvastatin10 MG na 28 za'a iya sayan 250-200 rubles, kuma Kanta10 mg No. 28 don 1500-1700 rubles.

Farashin Atoris, inda zaka siya

A cikin magunguna na Rasha, farashin maganin yana bambanta sosai, alal misali, farashin Atoris 10 mg No. 30 na iya bambanta tsakanin 400-600 rubles, farashin Atoris 20 mg No. 30 daga 450 zuwa 1000 rubles, allunan 40 mg No. 30 daga 500 zuwa 1000 rubles.

Kuna iya siyan allunan a Ukraine akan matsakaici: 10 MG No. 30 - 140 hryvnia, 20 MG No. 30 - 180 hryvnia, 60 MG No. 30 - 300 hryvnia.