Desmopressin - umarnin don amfani

Bayanin da ya dace da 30.07.2015

• Sunan Latin: Harshen
• Lambar ATX: H01BA02
• Tsarin sunadarai: C₄₆H₆₄N₁₄O₁₂S₂
• Lambar CAS: 16679-58-6

Abubuwan sunadarai

Desmopressin ne analog na roba vasopressin maganin antidiuretic, wanda ke yawan haɓaka daga haɓakar maɗaukaki glandar gland. An samo sinadarin ne ta hanyar kayan aiki na yau da kullun. vasopressin:1-maganin cysteine da maye gurbinsu 8-l-arginineyanzu a cikin kwayoyin halitta akan 8-D-arginine.

Kayan aiki yana da ƙarancin ingantaccen sakamako a kan madaidaicin tsokoki na gado na jijiyoyin bugun gini da gabobin ciki, amma ita anti-duretic sakamako bayyana da karfi sosai.

Magunguna da magunguna

The abu kunna Masu karɓar Vasopressin V2waɗanda suke a cikin ƙwayar epithelial nuna tubules kuma a cikin Hawan madaukai na Henle, wannan yana haifar da karuwa a cikin aiwatar da sake farfadowa da ruwa zuwa tasoshin jini, yana ƙarfafawa 8 abubuwan coagulation.

An cimma sakamako na antiduretic na miyagun ƙwayoyi tare da subcutaneous, ciki da ciki intramuscular management, tare da malami magunguna a hanci.

Rabin rayuwar haɓakar ƙwayar roba = mintina 75. Koyaya, za'a iya gano yawan abubuwan da ke tattare da abu a cikin jiki a cikin awanni 8-20, bayan gudanarwa. An tabbatar da alamun cutar polyuria ɓace bayan sau 2-3 na amfani da samfurin. Gudun cikin jijiya yafi tasiri fiye da gudanarwar cikin zuciya.

A cikin marasa lafiya tare da hawan jini da cutar Kwayan Willebrandt bayan allura guda na 0.4 μg na miyagun ƙwayoyi a kowace kilogiram 1 na nauyi, 8 coagulation factoryana ƙaruwa sau 3-4. Tasirin maganin yana fara bayyana bayan rabin sa'a kuma ya kai matsakaicin darajar shi a cikin rabin da rabi - 2 hours.

Hakanan, lokacin amfani da miyagun ƙwayoyi, ana lura da haɓaka mai sauri a cikin ƙwayar plasma plasminogenamma a lokaci guda matakin fibrinolysis ya kasance iri ɗaya ne.

Abubuwan yana haɗuwa a cikin kyallen hanta. Cleavage na faruwa rushe gada hade da enzyme transhydrogenases. Magunguna tare da fitsari an cire shi ko kuma a cikin yanayin metabolites mara aiki. Desmopressin yana da ƙarancin guba, a'a teratogenic ko Kayan aikin mutagenic.

Fom ɗin saki

An samar da miyagun ƙwayoyi a yawancin sigogi. Kafin zabar fom, ya kamata ka nemi likitanka don nemo wanda ya dace don maganin cutar.

Maganin maganin allura ana gudanar dashi ne ta hanyar intramuscularly, intravenously, subcutaneously.

Ana samun magungunan ta hanyar farin, allunan zagaye. A gefe ɗaya rubutu yana "rubutu D1" ko "D2". A rabe biyu na biyu. Baya ga sashin aiki mai aiki, desmopressin, abun da ke ciki ya haɗa da sterate magnesium, sitacin dankalin turawa, povidone-K30, lactose monohydrate.

Ana samun magungunan ta hanyar farin, allunan zagaye.

Saukad da hanci na ruwa mai ruwa mara launi. Wadanda suka kware sune chlorobutanol, sodium chloride, ruwa, hydrochloric acid. Sashi 0.1 MG da 1 ml.

Ruwan fili ne. An ɗauke shi a cikin kwalba na musamman tare da mai watsawa. Wadanda suka kware sune sorbate potassium, ruwa, hydrochloric acid, sodium chloride.

Pharmacokinetics

Rabin rayuwar rabin kwayoyin halitta shine minti na 75. Amma a lokaci guda, za a iya lura da miyagun ƙwayoyi a cikin kyawawan dabi'u a cikin jikin mutum na 8-20 hours bayan amfani. An bayyana cewa alamun polyuria ta ɓace bayan amfani da kwayoyi 2-3. A wannan yanayin, allurar rigakafi suna da tasiri fiye da gudanarwar cikin ciki.

A cikin mutanen da ke da cutar Willebrand, har da hemophilia tare da gudanarwa guda ɗaya na 0.4 μg / kg na kayan, an lura da karuwar 3-4 sau 8 kashi na 8 na coagulation na jini. Magungunan yana fara aiki bayan mintuna 30 daga lokacin da aka yi amfani da shi kuma ya kai darajar ƙima bayan awa 1.5-2.

A lokaci guda, yin amfani da miyagun ƙwayoyi yana haifar da haɓaka mai sauri a cikin ƙimar ƙwayar cutar ta plasminogen, kodayake alamun alamun fibrinolysis suna kasancewa iri ɗaya.

Maganin yana shafar metabolism a cikin hanta hanta. An lalata gada mai lalacewa ta hanyar enzyme transhydrogenase.

Rawanin abu mara canzawa ko samfuran metabolism marasa aiki yana faruwa tare da fitsari.

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Contraindications

• polydipsia na halin psychogenic ko yanayin haifuwa,
• gaban anuria,
• plasma hypoosmolality,
• riƙewar ruwa a jiki,
• kasancewar bugun zuciya tare da bukatar cututtukan diuretic,
• rashin lafiyan amsa ga magani.

An haramta gudanar da kwayar cutar cikin kwayar cutar tare da cutar W Wbbrand-Dian na sigogin 2b, kuma ban da angina mai tsayayye

Sashi da gudanarwa

Allunan ya kamata a ɗauka a baki, bayan 'yan sa'o'i bayan cin abinci (tare da amfani lokaci ɗaya, raunana shan ƙwayoyi, wanda zai haifar da raguwa a cikin tasirinsa). Likita ya zaba masu girma dabam da kuma lokacin da likitan yake so.

Mutanen da ke dauke da nau'in mellitus na sukari da farko suna buƙatar ɗaukar 0.1 mg na kayan sau 1-3 a rana. Bayan wannan, ya zama dole don ɗayan zaɓi zaɓi daban-daban, la'akari da tasirin da allunan suka yi, da kuma haƙurinsu ga mai haƙuri. A matsakaici, sashi shine 0.1-0.2 mg, ana ɗaukar sau 1-3 a rana.

Girman matsakaicin adadin bakin da aka yarda da shi a rana shine 1.2 MG.

Tare da rashin daidaituwa na dare, galibi suna shiga 0.2 MG na kayan a ciki da dare. Idan tasirin bai isa ba, an ninka kashi biyu zuwa 0.4 MG. Lokacin gudanar da jiyya, yakamata a taƙaita yawan shan ruwa a cikin rabin rabin rana. A matsakaici, ci gaba da jiyya yana ɗaukar kwanaki 90. Yin la'akari da hoton asibiti, likita zai iya tsawaita hanya (sau da yawa, kafin tsawaita magani, an soke magungunan don kwanaki 7, sannan, la'akari da bayanan asibiti da aka karɓa bayan janyewar magunguna, sun yanke shawara ko mai haƙuri yana buƙatar ci gaba da hanya).

Manya, tare da polyuria na nau'in dare, sau da yawa suna buƙatar shan 0.1 MG na miyagun ƙwayoyi a cikin dare. Idan babu sakamakon warkewa, yana yiwuwa a ninka kashi - zuwa 0.2 MG. A karkashin kulawar likita, sashi na iya ci gaba da ƙaruwa idan ya cancanta. Idan babu alamun ci gaba bayan watanni 1 na amfani da miyagun ƙwayoyi, ya kamata a dakatar da magani.

Ana amfani da fesa intranasal a cikin rabo na 10-40 mcg / day, wanda aka rarraba cikin yawancin amfani. Yara masu shekaru akalla watanni 3 da matsakaicin shekaru 12 ya kamata su daidaita suturar yau da kullun, wanda ke cikin kewayon 5-30 micrograms.

Dos na Desmopressin don iv, s / c, kuma ma / m injections sune 1-4 mcg / day (na manya). An yarda yara su shiga 0.4-2 microgram na miyagun ƙwayoyi kowace rana.

Idan babu sakamako bayan makon farko na jiyya, ya zama dole don daidaita suturar yau da kullun. Don zaɓar tsarin kulawa da yakamata a wasu lokuta yakan ɗauki lokaci mai yawa - cikin fewan makonni.

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Yawan abin sama da ya kamata

Guba tare da miyagun ƙwayoyi sau da yawa yakan haifar da riƙe ruwa da ci gaban alamun hyponatremia.

A cikin waɗannan halayen, ana buƙata don gudanar da isotonic na ciki ko maganin mafitsara na sodium chloride, ka kuma ba da magani na diuretic (furosemide) ga mai haƙuri.

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Haɗi tare da wasu kwayoyi

Haɗuwa tare da dopamine, musamman a manyan sigogi, na iya haifar da sakamako mai latsawa.

Indomethacin yana rinjayar yawan tasirin magani wanda Desmopressin ke motsawa.

Haɗin maganin tare da carbonate na lithium yana haifar da raguwa a cikin abubuwan antidiuretic dinta.

Dole ne a kula da hankali don haɗaka maganin tare da magunguna waɗanda ke kara haɗarin sakin maganin antidiuretic: kamar carbamazepine tare da chlorpromazine, phenylephrine tare da tricyclics, da epinephrine. Irin wannan haɗin zai iya haifar da tasirin vasopressor na kwayoyi.

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Aikace-aikacen yara

Girman sabis ɗin yau da kullun don yara waɗanda ba su da shekara 12 yana buƙatar gyara.

A cikin jarirai har zuwa shekara 1, shan maye tare da abu na iya haifar da ci gaba na seizures - dangane da haushi da miyagun ƙwayoyi a kan NS.

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Analogues na abu shine shirye-shiryen Vazomirin, Minirin da Emosint tare da Presinex, kuma ban da Adiuretin, Desmopressin acetate, Nourem tare da Nativa, Apo-Desmopressin da Adiuretin SD.

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Desmopressin yana karɓar kwalliya masu kyau a cikin lura da maganin rashin damuwa a yara, kodayake an lura cewa tasirin amfani dashi baya haɓaka nan da nan, amma bayan makonni da yawa. A lokaci guda, maganganun sun ce an yarda da maganin sosai.

Hakanan akwai sake dubawa game da tasiri na maganin a cikin cututtukan sukari na yanayin rashin sukari - amfani da shi yana inganta yanayin mai haƙuri, yana rage alamun cutar.

Hanyar aikin

Abunda yake aiki abu ne wanda aka inganta shi irin kwayar halittar vasopressin. Lokacin da miyagun ƙwayoyi ya shiga cikin jiki, ana karɓar masu karɓuwa na musamman, saboda wanda aka inganta aikin sake sarrafa ruwa. Coagulation na jini yana inganta.

A cikin marasa lafiya da hawan jini, ƙwayar tana ƙara yawan coagulation 8 sau 3-4. Akwai karuwa a yawan plasminogen a cikin jini.

Gudanar da ciki yana ba ku damar hanzarta cimma sakamako.

Magungunan yana haɓaka coagulation na jini.

Tare da kulawa

Idan har aka sami daidaituwa game da ma'aunin ruwa, toshewar hanji, cututtukan cututtukan zuciya da kodan, hadarin karuwar karfin mahaifa, yakamata a yi taka tsantsan yayin jiyya. Ana daukar dangi na dangi ya wuce shekaru 65.

Dos da tsarin jeri sun dogara da cutar, yanayin halayen mutum na haƙuri. Ya kamata a zaɓa su tare da likita. Ya kamata ku san kanku da umarnin don amfani.

Maganin farko na saukowar hanci, feshi ya bambanta daga 10 zuwa 40 mcg kowace rana. Ya kamata a dauka sau da yawa. Yara underan ƙasa da shekara 12 zasu buƙaci gyara. A gare su, an zaɓi kashi 5 zuwa 30 microgram a rana.

Tare da gabatarwar allura ga manya, sashi yana daga microgram 1 zuwa 4 a kilo kilogram na jikin mutum. A lokacin ƙuruciya, ya kamata a gudanar da microgram 0.4-2.

Idan ilimin bai kawo sakamako da ake tsammanin cikin sati guda ba, dole sai an gyara sashi.

Idan ilimin bai kawo sakamako da ake tsammanin cikin sati guda ba, dole sai an gyara sashi.

Side effects

Haushi, ciwon kai, rikicewa mai yiwuwa ne. Da wuya, marasa lafiya suna fada cikin rashin lafiya. Yawan jiki yana iya ƙaruwa, rhinitis na iya faruwa. A cikin wasu marasa lafiya, ƙwayoyin mucous na hanci sun kumbura. Amai, tashin zuciya, da ciwon mara na yiwuwa.

Hawan jini na iya ƙaruwa ko raguwa. Wasu lokuta oliguria, filasha mai zafi, halayen rashin lafiyan yana faruwa. Hyponatremia na iya faruwa. Lokacin amfani da allura, za'a iya lura da jin zafi a wurin allurar.

Idan ana amfani da magani don kula da yara 'yan ƙasa da watanni 12, raunin kansa yana yiwuwa.

Alamu don amfani

Amfani da Desmopressin an nuna shi don ganowa da lura da cututtukan cututtukan ƙwayar cuta na tsakiya.

Bugu da kari, alamomi daban daban na hanyoyin sashi:

• Allunan: yara sama da 5 da shekaru - na farko nocturnal enuresis, manya - bayyanar cututtuka na cutar nocturnal polyuria,
• Saddara hanci da fitsari hanci da ruwa: gwaji na gano ƙwaƙƙwaran ƙarfin ƙwayar kodan,
• saukad da hanci: m polyuria na asali na asali, wanda ya haifar da wata cuta ko shigarwar tiyata a kan tsarin juyayi na tsakiya, rauni.

Amfani da barasa

Ba a ba da shawarar shan giya yayin jiyya ba, saboda yana sa magani ya zama mai tasiri.

Magungunan yana da adadin adonai da yawa. Analogs sune Allunan, Nativa, Adiuretin, Spayys sprays, Vasomirin. Hakanan ana amfani da Desmopressin Acetate. Akwai sauran kwalliya, allunan da kuma mafita tare da kayan antidiuretic. Wataƙila amfani da magungunan jama'a.

Minirin kwatankwacin kwatancen Desmopressin ne.

Sashi da gudanarwa

Ana ɗaukar allunan a baki, wani lokaci bayan cin abinci.

• cutar insipidus na tsakiya: kashi na farko shine 0.1 mg 1-3 sau a rana ga yara da manya. Na gaba, an zaɓi kashi don yin la'akari da martani na mutum, zai iya zuwa daga 0.2 MG zuwa 1.2 MG kowace rana,
• first nocturnal enuresis: kashi na farko shine 0.2 MG a lokacin bacci, in babu ingantaccen sakamako na warkewa, ana iya karuwa zuwa 0.4 MG. Wajibi ne a iyakance abincin da yamma. Aikin na tsawon kwanaki 90. Bayan hutu na kwana 7, ana iya sake fara amfani da kwayoyin magani bisa shaidar asibiti,
• nocturnal polyuria a cikin manya: kashi na farko shine 0.1 MG a lokacin bacci, a cikin rashin sakamako da ake buƙata, ana ƙaruwa kowace kwanaki 0.1 ta 0.1 mg har sai an sami kashi wanda ya ba da sakamako mafi kyau.

Idan babu cikakkiyar amsa na asibiti bayan kwana 30 na magani, ya kamata a dakatar da maganin.

Sashi hanci hanci

Ana amfani da fesawa ta hanyar gudanarwar intranasal, danna ɗaya akan na'urar dosing ya dace da 0.01 MG na miyagun ƙwayoyi.

A cikin kula da yara, ya kamata a aiwatar da hanyar a karkashin kulawa ta manya.

Mafi kyawun kashi ana tantance shi ta zaɓin mutum.

• insipidus na ciwon sukari na tsakiya: manya - 0.01-0.04 mg, yara - 0.01-0.02 mg a rana. Ana aiwatar da hanyar sau ɗaya ko raba maganin da aka tsara zuwa kashi biyu don injections,
• Gwajin ƙwaƙwalwar koda: manya - 0.04 MG, yara sama da shekara 1 - 0.01-0.02 mg, yara thean shekaru 1 1 - 0.01 mg. Bayan gudanarwa, mara lafiya ya kwantar da mafitsara, a cikin awowi 8 masu zuwa, ana fitar da abinci sau 2 na fitsari don nazarin yanayin aikinsa. Matsakaicin yawan ruwan da mai haƙuri ya bugu yayin gwajin (awa 1 kafin binciken da kuma lokacin 8 hours masu zuwa) bai wuce 500 ml ba. Idan aka gano ƙididdigar osmolality a ƙasa 800 mOsm / kg a cikin manya da 600 mOsm / kg a cikin yara, an maimaita gwajin. Lokacin tabbatar da take hakkin ikon ƙwayar ƙwayar ƙwayar cuta, ana buƙatar ƙarin gwaje-gwaje.

Nasal ta fad'i

Saukad da ƙasa ana amfani da shi ne ta hanjin, ta hanyar shigar da hankali zuwa hancin hanci zuwa hancin hanci da ƙyallen kai daga baya da karkatar da kansa zuwa gefe.

Bayyanar da sakamako mai warkewa yana faruwa a cikin minti 30 bayan instillation na miyagun ƙwayoyi.

• cututtukan ƙwayar cuta na asali na asali: manya - 0.01-0.04 mg (2-8 saukad da), yara - 0.005-0.02 mg (1-4 saukad da) kowace rana. Ana gudanar da miyagun ƙwayoyi sau ɗaya, ko kuma kashi na yau da kullun ya kasu kashi biyu injections. Likita ya tsara adadin da kuma tazara tsakanin gwamnatoci daban-daban, la'akari da kwarewar mai haƙuri game da miyagun ƙwayoyi,
• m nau'i na tsakiyar polyuria: 0.01 mg kowane. Yakamata a tantance yadda ake amfani da ciwan diureis da na ruwa a sa'oin awa har sai an sami daidaituwa. A cikin awanni 3-5, lura da tsararren plasma da fitsari, maida hankali ne yawan sodium a cikin jini,
• nazarin ikon maida hankali na kodan: manya - 0.015 MG, yara sama da shekara 1 - 0.01-0.015 mg. Bayan instillation na miyagun ƙwayoyi, ana buƙatar narkewar mafitsara. Sannan ana tattara samfuran fitsari don tantance osmolarity, ana maimaita hanyar sau 4 tare da tazara na 1 awa. Idan ƙishirwa ta faru, an ba shi izinin ɗaukar ruwa fiye da 200 ml na tsawon lokacin (awa 1 kafin binciken da kuma awanni 8 masu zuwa) na binciken.

Umarni na musamman

Bai kamata a yi amfani da Desmopressin a cikin marasa lafiya da ke tattare da rikice-rikice ba ko yayin shan magunguna waɗanda zasu iya haifar da riƙe ruwa a cikin jiki da rikicewar lantarki.

Marasa lafiya da ke da saurin rashin wayewa zuwa awa 1 kafin da kuma a cikin awanni 8 bayan amfani da maganin yakamata a rage yawan shan ruwa - wannan zai rage hadarin illa.

Amfani da Desmopressin don maganin rashin maganin ciwon hanji da ke faruwa a yara da marasa lafiya yana haifar da haɗarin haɓakar ƙwayar cuta ta hanji.

Marasa lafiya tare da polyuria daga 2.8 zuwa lita 3 da ƙananan matakan plasma sodium na farko suna cikin haɗarin sakamako masu illa.

Tare da tsananin taka tsantsan, ana bada shawara don amfani da miyagun ƙwayoyi a cikin marasa lafiya fiye da shekaru 65 saboda babban haɗarin riƙewar ruwa, haɓakar hyponatremia da sauran tasirin da ba a so. Ya kamata a ba wa mara lafiya ikon kula da jihar da kuma na yau da kullun (kafin jiyya, bayan kwana uku na maganin kuma a kowane karuwa na ƙaddara) ƙuduri na matakin sodium taro a cikin jini na jini.

Idan akwai zazzabi, cututtuka na ciki ko gastroenteritis, ya kamata a daina amfani da maganin.

Don hana hyponatremia, ana ba da shawarar karatu akai-akai don ƙayyade matakin sodium a cikin jini, musamman lokacin da ake haɗa allunan tare da maganin tricyclic antidepressants, serotonin inhibitors, chlorpromazine, carbamazepine, sauran magunguna waɗanda ke haifar da ciwo na rashin isasshen ɓoyayyen kwayoyin antidiuretic, kuma a hade tare da magungunan anti-steroidal NSAIDs).

Bayyanar cututtuka da kuma kula da matsanancin urinary rashin daidaituwa, nocturia da / ko dysuria, cututtukan urinary fili, mafitsara ko ciwan prostate, zubar da cututtukan cututtukan ƙwayar cuta, cututtukan ƙwayar cuta, polydipsia, da barasa ya kamata a aiwatar da su kafin amfani da Desmopressin.

A cikin yara 'yan ƙasa da shekara 1, gwaji don tantance ƙarfin ƙwayar kodan ya kamata a gudanar da shi kawai a asibiti.

Bayan gudanar da gwaje-gwaje na ganewar asali, an yarda wa mai haƙuri ya karɓi ruwan ɗumi a cikin girma wanda ke ba da ƙishirwa.

Ba za a iya ba da allurar sashi don yara ba idan adadin da ake buƙata don maganin yana ƙasa da 0.01 MG.

Nazarin ikon maida hankali ne da kodan tare da saukowar yara a cikin shekara 1 yakamata a gudanar dashi a lokuta na musamman, tunda a wannan zamani an rage karfin yawan kodan. Dole ne a aiwatar da wannan hanyar ta likitan ilimin yara. Yayi yawa sosai a cikin jarirai na iya haifar da hangula daga tsarin juyayi, wanda ke tattare da haɓaka mawuyacin hali. A yayin tattara fitsari, ana buƙatar cikakken wariyar ruwa na ruwa.

Tunda tare da mummunan rhinitis, ɗaukar abubuwan saukad da ƙasa yana da illa, ana bada shawara don amfani da miyagun ƙwayoyi a ciki.

Tare da insipidus na ciwon sukari na asalin tsakiya, gudanarwar intranasal na desmopressin yana ƙara haɗarin haɓakar haɓakar hyponatremia.

Hulɗa da ƙwayoyi

Tare da amfani da Desmopressin lokaci guda:

• indomethacin na iya haifar da karuwa a cikin aikin desmopressin ba tare da kara tsawon sa ba,
• tetracycline, glibutide, norepinephrine, shirye-shiryen lithium suna rage tasirin maganin,
• masu kara karfin jini suna inganta tasirinsu,
• zabin maganin serotonin inhibitors, maganin tricyclic antidepressants, carbamazepine, chlorpromazine zai iya haifar da ciwo na rashin isasshen maganin antidiuretic hormone, karuwar tasirin antidiuretic na desmopressin, ƙara yawan haɗarin riƙe ruwa da ci gaban hyponatremia,
• NSAIDs suna kara haɗarin riƙe ruwa a cikin jiki, abubuwan da ke faruwa na hyponatremia,
• dimethicone yana rage yawan shan ƙwayoyi,
• loperamide da sauran magunguna waɗanda ke rage jinkirin peristalsis na iya haɓaka matakan plasma na desmopressin har sau 3 kuma suna ƙara haɓakar haɗarin riƙe ruwa da hyponatremia.

Analogs na Desmopressin sune: Allunan - Minirin, Nativa, Nourem, feshi - Apo-Desmopressin, Presineks, Minirin, Vasomirin.

Haɗa kai

Amfani da ciki, musamman a manyan sashi, tare da dopamine na iya inganta tasirin mai latsawa.

Indomethacin na iya shafar zafin bayyanar Desmopressin ga jiki.

Yayin shan magani tare da kabarin lithium, tasirin maganin ta mai rauni.

Tare da taka tsantsan, abu ya kamata a haɗu tare da kwayoyi waɗanda ke haɓaka fitarwa. maganin antidiuretic: chlorpromazine, carbamazepine, maganin tricyclic antidepressants, phenylephrine, epinephrine. Haɗin wannan zai iya haifar da karuwa a cikin aikin vasopressor na Desmopressin.

Aikin magunguna

Desmopressin alama ce ta yanayin arginine-vasopressin na halitta tare da tasirin maganin antidiuretic.

Idan aka kwatanta da vasopressin, yana da ƙarancin tasirin sakamako akan ƙoshin lafiya na jijiyoyin jini da gabobin ciki, wanda ya faru ne sakamakon canje-canje a cikin tsarin ƙirar desmopressin idan aka kwatanta da ƙwayar vasopressin na halitta - lalata kwayar 1-cysteine ​​da maye gurbin 8-L-arginine tare da D-arginine.

Theara yawan peritability na epithelium na distal sassan tubules da aka haɗa don ruwa kuma yana ƙaruwa da farfadowa. Yin amfani da Desmopressin a cikin insipidus na ciwon suga yana haifar da raguwa a cikin yawan fitsari da kuma haɓaka lokaci guda a cikin ƙwayar fitsari da raguwa a cikin ƙwayar jini na osmolality na jini. Wannan yana haifar da rage yawan urination da raguwa a cikin ƙwayar nocturnal polyuria.

Matsakaicin tasirin antidiuretic yana faruwa ne lokacin da aka sha shi a baki - bayan awoyi 4-7. Maganin antidiuretic lokacin da aka sha shi a cikin ƙwayar 0.1-0.2 mg - har zuwa 8 hours, a kashi na 0.4 mg - har zuwa awanni 12.

Bedwetting

• Tambayi wata ƙwararren mahaifa wata tambaya
• Sayi magani
• Duba cibiyoyin

Tsarin magunguna

Mai sana'antawa ya samar da maganin a wasu nau'ikan magungunan, daga cikinsu:

1. Nasal saukad da, wanda ruwa ne bayyananne, mara launi. Sanya cikin kwalayen dropper, kowane ɗayan yana dauke da 5 ml na miyagun ƙwayoyi.
2. Fesa hanci "Desmopressin". Ruwan bayyane yake ba tare da launi ba. Sanya cikin kwalaben da aka yi da gilashin duhu kuma sanye take da na'urar ta musamman don fesa. Kowane kwalban yana riƙe da allurai 50.
3. Kwayoyi Su farare ne masu launi, a gefe guda akwai haɗari. Sanya cikin kwantena polyethylene na 28, 30, 90, ko a cikin fakiti mai bakin ciki 10, 30.

Ba a nuna umarnin ba don amfani da "Desmopressin" analogues. Za mu yi la’akari da su a ƙasa.

Abubuwan da ke aiki a cikin allunan da fesa hanci shine desmopressin acetate, cikin saukad - desmopressin. A cikin kera allunan, ana amfani da kayan taimako kamar magnesium stearate, sitaci dankalin turawa, povidone-K30, lactose monohydrate.

Abubuwan taimako a cikin fesawa sune: tsarkakakken ruwa, hydrochloric acid, sodium chloride, potassium sorbate.

Kamar yadda ake amfani da ƙarin abubuwan haɗi a cikin saukad da ruwa: tsarkakakken ruwa, hydrochloric acid, sodium chloride, chlorobutanol.

Analogues na allunan Desmopressin da fesa ba su da wuyar karba, amma likitan da ke halartar yakamata ya yi wannan.

Sakamakon mummunan amfani da miyagun ƙwayoyi

A kan tushen amfani da saukad, feshi da Allunan Desmopressin, mai haƙuri na iya haɓaka halayen da ba su da kyau, dangane da abin da aka ba da shawarar yin la'akari da allurai da likita ya umarta. Mafi sau da yawa tare da ilimin aikin likita yana bayyana:

• Jin zafi a wurin allurar.
• Take hakkin lacrimation.
• Allergic conjunctivitis.
• The tides.
• Bayyananniyar bayyanar a kan fata.
• Rayayyar
• Colic na ciki.
• Amai
• Ciwon ciki.
• Ciwon ciki
• Kumburi a bango na riƙewar ruwa a jikin mutum.
• Hyponatremia.
• Oliguria.
• Aseara ko raguwa a cikin karfin jini idan an gudanar da maganin a cikin hanzari.
• Kumburi daga cikin mucous membranes a cikin hanci hanci.
• Hypoosmolality.
• Rhinitis.
• Rage nauyi.
• Rashin sani.
• Rikicewa.
• Dizziness.
• Ciwon kai.
• Coma

Idan wani mummunan halayen ya faru, yana da mahimmanci sanar da likitanka. An tabbatar da wannan ta umarnin don amfani. Analogs na Desmopressin suna da irin wannan sakamako.

Yin amfani da magani: yadda ake yin shi daidai

Bayanin kula da jiyya da sashi na kowane mai haƙuri an yanke shi ne da likita.

Lokacin amfani da nau'ikan magungunan intranasal, ana nuna alamar har zuwa 40 mgk na miyagun ƙwayoyi kowace rana. Dole ne a raba kashi da aka nuna a aikace-aikace da yawa. A cikin kulawa da yara, ana buƙatar daidaita sashi, tunda har zuwa 3 μg kowace rana ana yawan amfani dashi.

Idan an tsara tsarin maganin a intramuscularly, intravenously, subcutaneously, to, marasa lafiya manya suna buƙatar amfani har zuwa 4 μg kowace rana, yara - har zuwa 2 μg.

Idan babu tasirin warkewa yayin sati daya na amfani da miyagun ƙwayoyi, dole ne a nemi likita don daidaita sashi. Yawancin lokaci yana ɗaukar makonni da yawa don zaɓar madaidaicin tsarin magani.

Yanayin ajiya na miyagun ƙwayoyi

Adana miyagun ƙwayoyi a cikin wurin da ba a iya kaiwa ga yara, yawan zafin jiki wanda bai wuce digiri 30 ba.

Kiyaye miyagun ƙwayoyi daga isa ga yara.

Haihuwa da lactation

Ba a gudanar da cikakken isasshen bincike mai zurfi game da lafiyar desmopressin yayin daukar ciki da kuma lactation ba. Idan ya zama dole don amfani da desmopressin a cikin wannan rukuni na marasa lafiya, ana tsammanin amfanin lafiyar likita ga mahaifiya da kuma haɗarin yiwuwar tayin da jariri.

Shirye-shirye da suka kunshi DESMOPRESSIN (DESMOPRESSIN)

• APO-DESMOPRESSINE (hanci na fitar da hanci). 10 mcg / 1 kashi: fl. 2.5 ml (allurai 25) ko 5 ml (allurai 50) • EMOSINT (EMOSINT) mafita d / allura. 4 μg / 0.5 ml: amp. Guda 10 guda goma. • MINIRIN® (MINIRIN) shafin. mcg mai zurfin 120 m: 10, 30 ko kwamfutoci 100. • MINIRIN® (MINIRIN) shafin. 200 mcg: pcs 30. • MINIRIN® (MINIRIN) shafin.

100 mcg: inji mai kwakwalwa 30. • EMOSINT (EMOSINT) maganin allura. 40 mcg / 1 ml: amp. Kwafsayo guda 10. 50 allurai tare da dosing. • na'urar MINIRIN® (MINIRIN) feshin hanci. 10 mcg / 1 kashi: fl. 2.5 ml (allurai 25) ko 5 ml (allurai 50) • MINIRIN® (MINIRIN) shafin.

240 mcg na sublingual: 10, 30 ko 100 raka'a • PRESINEX (hanci na fitar da hanci). 10 mcg / 1 kashi: fl. Allurai 60 • EMOSINT (EMOSINT) bayani d / allura. 20 mcg / 1 ml: amp. Guda 10. • DESMOPRESSIN (saukowar hanci) 100 mcg / 1 ml: vial. 5 ml

• MINIRIN® (MINIRIN) shafin.

mcg na 60 60: 10, 30, ko 100 inji mai kwakwalwa.