Metformin 850: umarni don amfani, bita da kuma alamun analogues

Allunan mai rufi, 500 MG, 850 MG, 1000 MG

Tabletaya daga cikin kwamfutar hannu ya ƙunshi

abu mai aiki - metformin hydrochloride (dangane da abu 100%) 500 MG, 850 MG ko 1000 MG,

magabata: sitaci 1500 (wani bangare wanda aka riga aka shirya), povidone, croscarmellose sodium, magnesium stearate, microcrystalline cellulose,

harsashi Opadry II: polyvinyl barasa (wani sashi na ruwa mai ruwa), macrogol 3350 (polyethylene glycol), canza launin launi (titanium dioxide (E 171), varnish na aluminika dangane da indigo carmine (E 132), varnish na aluminika dangane da quinoline rawaya (E 104)

Allunan mai launin kore tare da biconvex farfajiya tare da haɗari (don adadin 500 na mg da 1000 mg).

Allunan mai launin kore tare da farfajiya na biconvex ba tare da haɗari ba (don sashi na 850 MG).

Facungiyar makamai

Yana nufin don maganin ciwon sukari. Magungunan sukari na rage sukari don maganin baka. Biguanides. Metformin.

Lambar ATX A10BA02

Kayan magunguna

Pharmacokinetics

Bayan gudanar da baki, yana sha da sauri cikin hanji. Cikakken azumi bioavailability shine 50-60%.

Matsakaicin maida hankali (Cmax) an kai shi ne bayan kimanin awanni 2, ingin tare da abinci yana rage Cmax da 40% kuma yana rage jinkirin nasa ta minti 35. Plasma maida hankali bai wuce 1 μg / ml.

Ofimar rarraba (Vd) shine lita 296-1012. Sadarwa tare da sunadaran plasma ba shi da mahimmanci, yana iya tarawa cikin sel jini.

Rabin-rayuwar (T½) kusan awa 6.5 ne (farawa T½ daga 1.7 zuwa 3 hours, tashar - daga 9 zuwa 17 hours). Enalarancin fitarwa ya wuce 400 ml / min.

Ya kyankyasar kodan, akasarinsu a yanayin da ba a canza su ba (zazzabin dunƙule da tubular ɓoye) da cikin hanjin ciki (har zuwa 30%).

A cikin gazawar koda, rarrabuwa yana raguwa gwargwadon aikin yarda. T½ tsawaita, akwai haɗarin haɗuwa da miyagun ƙwayoyi kuma yawan haɗarin metformin a cikin jini yana tashi.

Pharmacodynamics

Metformin yana rage hyperglycemia, baya haifar da ci gaban hypoglycemia. Ba kamar sulfonylurea ba, ba ta haifar da insulin insulin kuma ba ya haifar da tasirin hypoglycemic a cikin mutane masu lafiya. Yana rage duka matakan glucose na farko da matakin glucose bayan cin abinci a cikin jini na jini.

Za'a iya samun sakamako na hypoglycemic na metformin ta hanyar matakai uku:

- rage samar da glucose a cikin hanta saboda hanawar gluconeogenesis da glycogenolysis,

- inganta haɓakawa da kuma amfani da gllu na yanki a cikin tsokoki ta hanyar ƙara ƙarfin halin insulin,

- jinkirta sha da glucose a cikin hanji.

Metformin yana haɓaka hadaddun ƙwayar glycogen, yana tasiri glycogen synthetase. Capacityara ƙarfin jigilar kayayyaki na kowane nau'ikan jigilar jini na membrane.

Ko da kuwa tasirin sa game da glycemia, metformin yana da tasirin gaske akan metabolism na lipid: yana rage adadin kuzari, ƙarancin kitsen lipoproteins da triglycerides.

Theara hankalin mai karɓar mahaifa zuwa insulin da kuma amfani da glucose ta sel. Yana hana gluconeogenesis a cikin hanta. Yana jinkirta ɗaukar carbohydrates a cikin hanjin.

Sashi da gudanarwa

Monotherapy ko magani a hade tare da sauran jami'in na baki hypoglycemic.

Yawanci, kashi na farko shine 500 MG ko 850 MG na metformin sau 2-3 a rana yayin ko bayan abinci. Bayan kwanakin 10-15 na magani, dole ne a daidaita adadin gwargwadon sakamakon ma'aunin matakan glucose matakin. Increasearawar hankali a hankali yana taimakawa rage girman sakamako daga narkewa.

Matsakaicin shawarar da aka ba da shawarar ita ce 3000 MG kowace rana, ya kasu kashi uku. A cikin jiyya na babban allurai, ana amfani da Metformin a cikin sashi na 1000 MG. Idan akwai yiwuwar canzawa zuwa jiyya tare da Metformin, to ya zama dole a daina shan wani wakilin maganin cututtukan ƙwayar cuta.

Hade jiki tare da insulin.

Don cimma nasarar sarrafa matakan glucose na jini, ana iya amfani da metformin da insulin azaman maganin haɗuwa. Yawanci, kashi na farko shine 500 MG ko 850 MG na miyagun ƙwayoyi Metformin sau 2-3 a rana, yayin da aka zaɓi kashi na insulin bisa ga sakamakon auna glucose jini.

A cikin tsofaffi marasa lafiya dole ne a zaɓi ƙimar metformin gwargwadon kimanta aikin aikin na koda, wanda dole ne a yi shi akai-akai.

Abun da ya shafi samfurin magani da kaddarorin magungunan sa

Magungunan yana hana haɓaka aiki na abubuwa masu laushi na jikin bangon tsarin jijiyoyin jiki. An bayyana sakamako mai kyau na miyagun ƙwayoyi akan janar yanayin tsarin zuciya da jijiyoyin bugun jini kuma yana hana ci gaba da cutar ciwon sukari.

Jiyya na ciwon sukari tare da Metformin kawai likitanku zai iya yin wasiyyarsa bayan cikakken binciken mai haƙuri. Tsawon lokacin jiyya da adadin maganin da aka yi amfani da shi an ƙaddara yin la'akari da duk abubuwan aikin cutar a jikin mai haƙuri.

Abubuwan da ke aiki da maganin shine Metformin hydrochloride. Tabletaya daga cikin kwamfutar hannu yana ƙunshe da nauyin 850 na ƙwayoyin mai aiki. Baya ga babban fili, abun da ke cikin magungunan ya hada da mahallin sunadarai masu taimakawa.

Abubuwan sunadarai masu guba da ke cikin magunguna sune masu zuwa:

• alli phosphate dibasic,
• sitaci masara
• lactose
• povidone
• sodium benzoate,
• foda talcum
• magnesium stearate,
• sitaci soda sittin glycolate,
• titanium dioxide
• hydroxypropyl methylcellulose,
• ethyl cellulose,
• prolylene glycol
• polyethylene glycol.

Samun Metformin baya tasiri matakin hormone a jikin mutum, amma yana ba da gudummawa ga canji a cikin harhada magunguna, wanda ke faruwa sakamakon raguwa a cikin rabo tsakanin insulin da kuma 'yanci, karuwa a cikin sashin jikin mutum tsakanin insulin da proinsulin. Ofayan mafi mahimman matakai a cikin aikin aiwatar da miyagun ƙwayoyi shine haɓaka amfani da glucose ta hanyar ƙwayoyin tsoka.

Abunda yake aiki yana inganta hawan jini a cikin hanta kuma yana taimakawa hanzarta sarrafa glucose cikin glycogen. Amfani da Metformin 850 MG na inganta abubuwan da ke cikin fibrinolytic na jini. Wannan shi ne saboda hanawar ƙwaƙwalwar ƙwaƙwalwar ƙwayar plasminogen mai hanawa.

Ana ɗaukar ƙwayar abu mai aiki daga lumen ƙwayar gastrointestinal kuma alama ce da ke fitowa daga 48 zuwa 52%. Rabin rayuwar rayuwa mai aiki shine kimanin awa 6.5. Abubuwa masu aiki suna daga jikin mutum ta asali. Abubuwan da ke aiki basu da ma'amala tare da abubuwan gina jiki na plasma jini. Rarraba magungunan yana faruwa ne a cikin gland shine yake ji, ƙwayar tsoka, hanta da hanta. Drawacewa daga jiki ta hanyar ƙodan yayin aiwatar da fitsari.

Tare da haɓaka rikice-rikice a cikin aiki na tsarin urinary, miyagun ƙwayoyi sun tattara cikin kodan.

Alamu da magunguna don amfani da magani

Babban alamu don amfani sune masu zuwa:

1. kasancewar nau'in ciwon sukari na 2 na cuta ba tare da nuna hali ba zuwa ketoacidosis,
2. kasancewar kamuwa da cutar sikari idan babu inganci daga maganin rage cin abinci,
3. lura da ciwon sukari mai nau'in 2 a hade tare da ilimin insulin, musamman tare da ƙaddara mai kiba, wanda ke haɗuwa tare da bayyanar juriya na sashin insulin na hormone.

Babban contraindications ga yin amfani da miyagun ƙwayoyi a cikin lura da ciwon sukari na type 2 sune kamar haka:

• ci gaba a cikin jikin mai ciwon sukari ketoacidosis, ciwon sukari precoma ko coma,
• koda mai aiki,
• fitowan da ci gaba a jikin mai haƙuri da cututtukan da ke tattare da haɗarin aiki na ƙarancin ƙwayar cuta - rashin ruwa, zazzabi, ƙwanƙwasawa, cututtuka na kodan, haɓakar cututtukan zuciya,
• da ci gaban m da na kullum cututtuka da za su iya tsokani ci gaban da hypoxia nama,
• mummunan ayyukan cikin jiki da mara lafiya na karbar raunin jiki,
• abin da ya faru da ci gaban cuta a cikin aiki na hanta,
• mara lafiya yana da yawan barasa ko shan guba mai guba,
• ci gaban lactic acidosis a cikin jiki,
• bukatar abinci mai karancin kalori,
• tsawon lokacin haihuwa,
• lactation zamani
• mara lafiya yana da rashin kwanciyar hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

An hana yin amfani da Metformin kwanaki 2 kafin da kwana 2 bayan binciken radioisotope na jiki ta amfani da abubuwan da ke tattare da sinadarin aidin.

Umarnin don amfani da miyagun ƙwayoyi

Domin sanin yadda ake shan magungunan daidai, yakamata ku nemi likitan ku. Yakamata a bincika mai haƙuri umarnin yin amfani da Metformin.

Ana saita kashi na miyagun ƙwayoyi ne ta hanyar halartar endocrinologist. Likita ya kayyade sashi don kowane mai haƙuri daban-daban, la'akari da sakamakon da aka samu yayin nazarin jikin mutum da yin la’akari da halayen jikin mai haƙuri. Yawan maganin da mai haƙuri ya kamata ya sha ya dogara da matakin glucose a cikin jini na jini a jikin mai haƙuri.

Don ɗaukar Metformin daidai, kashi na farko ya kamata ya zama daga 500 zuwa 1000 MG kowace rana, wanda shine Allunan 1-2. Bayan kwanakin 10-15 na shiga, bisa ga shawarar endocrinologist na lura da mai haƙuri, ƙarin haɓaka matakin zai yiwu idan an buƙaci wannan ta hanyar yawan abubuwan glucose a jikin mai haƙuri.

Umarnin don amfani yana ba da shawarar amfani da 1500-2000 MG na miyagun ƙwayoyi azaman maganin kiyayewa, wanda shine Allunan 3-4, kuma mafi girman adadin da aka ba da izinin shan shine 3000 MG kowace rana.

Game da batun kula da cututtukan sukari na 2 na mellitus a cikin tsofaffi marasa lafiya, kashi da na'urar likita ta yi amfani da ita kada ya wuce 1 g ko allunan 2 a rana.

Allunan ya kamata a sha a baka ba tare da taunawa ba ko a kai tsaye bayan cin abinci. Ya kamata a sha miyagun ƙwayoyi tare da karamin adadin ruwa. Don hana haɓaka sakamako masu illa a cikin jiki, ana bada shawarar sashi na yau da kullun don kasha kashi 2-3.

Tun lokacin da kuke shan maganin, akwai babban yiwuwar haɓakar lactic acidosis, ana rage kashi da aka yi amfani da shi don maganin nau'in ciwon sukari na 2 na mellitus idan mai haƙuri yana da mummunar cuta na rayuwa.

Game da kulawa na lokaci guda tare da insulin a cikin kashi na ba fiye da raka'a 40 a kowace rana ba, sakin magunguna yana canzawa. A cikin jiyya da ke buƙatar kashi na yau da kullun na insulin fiye da raka'a 40 a kowace rana, ya kamata a dauki matakan kulawa da tsananin kulawa. Zabi sashi ya kamata a yi a wannan yanayin a asibiti karkashin kulawar akai-akai na halartar likita.

Metformin kawai yana rage yawan glucose a cikin mutane masu ciwon sukari ba tare da nuna abubuwan da suka mallaka a cikin mutum mai lafiya ba.

Side sakamako na miyagun ƙwayoyi a jiki

Tare da yin amfani da magani na tsawan lokaci, mai yuwuwar faruwa a jikin rikice-rikicen da ke tattare da shan ƙwayoyin Vitamin B12.

Tare da tsawanta yin amfani da miyagun ƙwayoyi, ya kamata a kula da kulawa ta musamman don lura da yanayin aikin hanta da ƙodan.

Lokacin amfani da miyagun ƙwayoyi, waɗannan sakamako masu illa na iya faruwa:

1. Daga aikin gastrointestinal tract, ana iya samun rikice-rikice, ana nuna su ta hanyar bayyanar jin tashin zuciya, amai, jin zafi a ciki, raguwa ko rashin ci, bayyanar dandano mai ƙarfe a bakin.
2. Daga fata akwai yiwuwar halayen rashin lafiyan ta hanyar fatar fata.
3. Tsarin endocrine yana da ikon amsawa game da amfani da miyagun ƙwayoyi ta hanyar ƙirƙirar yanayin hypoglycemic. Mafi yawan lokuta, irin wannan yanayi yana faruwa ne sakamakon karancin magunguna.
4. A wani ɓangaren sashi na tafiyar matakai na rayuwa a lokuta mafi wuya, lokacin ɗaukar isasshen allurai, ci gaban lactic acidosis a cikin ƙila yana yiwuwa. Idan wannan yanayin ya faru, ana buƙatar dakatar da maganin.
5. Tsarin jijiyoyin jini yana da ikon amsa magunguna ta hanyar samuwar a wasu halayen cutar megaloblastic.

Sakamakon babban haɗari ga jiki, amfani da metformin a gaban raunin koda a cikin mutum ya kamata a dakatar dashi ko yakamata a ɗauka ƙarƙashin kulawar likita kuma a cikin ƙaramin sashi.

Yawancin masana kimiyyar halittar endocrinologists a cikin wannan yanayin suna ba da shawarar dakatar da miyagun ƙwayoyi gaba daya, da ɗaukar shi a cikin raguwa sosai, tunda sa ido akan abubuwan sukari shine mafi mahimmanci.

Gaskiyar ita ce haɓaka sukari na jini na iya haifar da ƙarin rikice-rikice a cikin jiki wanda zai haifar da karuwar yiwuwar mummunan sakamako.

Umarnin na musamman don amfanin Metformin

Lokacin da ake shirin yin ciki ko lokacin da ya faru, ya kamata a dakatar da maganin. Game da ciki, ana maye gurbin amfani da miyagun ƙwayoyi don lokacin haila ta hanyar maganin insulin.

Tunda babu bayanai game da yiwuwar shigar shigar da abubuwan da ke cikin miyagun ƙwayoyi da kuma kayan aiki a cikin abin da ke cikin madara, lokacin amfani da nono, ya kamata a dakatar da amfani da maganin. Idan akwai buƙatar gaggawa don amfani da Metformin yayin shayarwa, ya kamata a dakatar da ciyar da nono.

An haramta yin amfani da miyagun ƙwayoyi ga yara da matasa a ƙarƙashin shekara 18.

Likitoci ba su ba da shawarar yin amfani da miyagun ƙwayoyi a cikin lura da ciwon sukari a cikin tsofaffi, wanda shekarunsa ya kai shekaru 60 da yin babban aiki mai dangantaka da ƙara yawan damuwa a jiki. Wannan shawarar ta kasance saboda gaskiyar cewa irin waɗannan marasa lafiya suna da matukar yiwuwar haɓaka lactic acidosis a cikin jiki.

Game da shan Metformin, ana iya haɗe shi tare da wakilai waɗanda aka samo daga sulfonylurea. Tare da irin wannan haɗuwa na ƙwayar cuta, ana buƙatar saka idanu musamman game da yanayin alamar glucose a cikin jiki.

Haramun ne a sha giya da magunguna masu dauke da ethanol a lokacin shan maganin. Shan Metformin a lokaci guda tare da barasa na iya tayar da haɓakar ci gaban lactic acidosis a cikin haƙuri tare da ciwon sukari.

Lokacin amfani da miyagun ƙwayoyi, an ba shi izinin motsa motoci da injuna, tun da yake gwamnatinsa ba ta tasiri da ikon tuki.

Kudin Metformin, analogues da nazarinsa na haƙuri game da amfani da miyagun ƙwayoyi

Kwayoyi masu zuwa sune analogues na Metformin:

• Bagomet,
• Glycon
• Glyminfor,
• Glyformin
• Glucophage,
• Glucophage Tsawon,
• Langerine
• Methadiene
• Metospanin
• Metfogamma 500, 850, 1000
• Metformin
• Karin Richter,
• Metformin Teva,
• Metformin hydrochloride,
• Nova Sanda
• Lankaranna,
• Siofor 1000,
• Siofor 500,
• Siofor 850,
• Sofamet
• A tsari,
• Tsarin Pliva.

Reviews game da amfani da miyagun ƙwayoyi ta hanyar marasa lafiya don lura da ciwon sukari suna nuna cewa wannan magani yana da tasiri a jikin mutum, wanda ke ba ka damar sarrafa yawan glucose a cikin jiki.

Akwai sake dubawa da yawa game da magungunan da ke nuna canji mai kyau a jikin mutum yayin shan Metformin ko analogues da bayyanar ingantaccen kuzari a cikin maganin cutar sankara. Mafi sau da yawa, marasa lafiya da ke fama da ciwon sukari mellitus da kiba suna nunawa a cikin sake duba su cewa yin amfani da Metformin a cikin aikin maganin ƙwaƙwalwa ya rage nauyin jiki.

Farashin magungunan a cikin magungunan kasar ya dogara da yankin da kuma shirya maganin.

Kudin magungunan Metformin Teva 850 MG a cikin ƙasa shine matsakaici na 100 rubles a kowane fakitin da ke ɗauke da allunan 30.

Magunguna kamar Metformin Canon 1000 MG yana da matsakaicin tsada a cikin ƙasar 270 rubles a kowane kunshin, wanda ya ƙunshi allunan 60.

Kudin magungunan sun dogara da yawancin Allunan suna cikin kunshin. Lokacin da sayen maganin, ya kamata a tuna cewa hutunsa yana gudana ne kawai a kan takardar sayan magani daga likitan halartar.

A cikin bidiyon a cikin wannan labarin, Dr. Myasnikov zai yi magana game da ka'idodin aikin Metformin a cikin ciwon sukari.