Simvastatin: umarnin don amfani, analogues, farashi da bita

Simvastatin magani ne tare da kaddarorin rage kiba. Samun ƙwayar ta amfani da ƙwayar sunadarai daga samfurin enzymatic metabolism na Aspergillus terreus.

Tsarin sunadarai na abu abu ne mai kama da lactone. Ta hanyar canzawar kwayoyin halittu, tasirin cholesterol yana faruwa. Yin amfani da miyagun ƙwayoyi yana hana haɗarin lipids mai guba sosai a jiki.

Molecules na abu suna ba da gudummawa ga rage yawan ƙwayar plasma na triglycerides, ƙananan ƙwayoyin atherogenic na lipoproteins, kazalika da matakin jimlar cholesterol. Arfafawar ƙwayar ƙwayar atherogenic lipids yana faruwa ne saboda dakatarwar samuwar cholesterol a cikin hepatocytes da haɓaka yawan adadin tsarin karɓa don LDL akan membrane na sel, wanda ke haifar da kunnawa da amfani da LDL.

Hakanan yana haɓaka matakin babban lipoproteins mai yawa, yana rage ƙimar lipids na atherogenic zuwa antiatherogenic da kuma matakin cholesterol kyauta zuwa gungun antiatherogenic.

Dangane da gwajin asibiti, ƙwayar ba ta haifar da maye gurbi ba. Adadin farawa na warkewar tasirin sakamako 12 na farkon bayyanuwar tasirin shine kwanaki 12-14, mafi girman tasirin warkewa yana faruwa wata daya bayan fara amfani. Sakamakon ya kasance na dindindin tare da tsawan magani. Idan kun daina shan magani, matakin kwayoyi masu narkewa zai koma yadda yake.

Abubuwan da ke cikin miyagun ƙwayoyi suna wakiltar abubuwan da ke amfani da Simvastatin da kayan haɗin taimako.

Abun yana da babban narkewa da karancin bioavailability. Shiga jini, yana ɗaure wa albumin. Tsarin maganin yana aiki da takamaiman halayen magunguna.

Metabolism din Simvastatin yana faruwa a cikin hepatocytes. Yana da tasirin "hanyar farko" ta cikin sel hanta. Zubar da jini yana faruwa ta hanyar narkewa (har zuwa 60%) a cikin nau'i na metabolites marasa aiki. Theaya daga cikin ƙananan ƙwayoyin yana zubar da shi ta hanyar da aka lalata.

Abun ciki da sashi tsari

Simvastatin (INN ta radar - simvastatin) wani abu ne mai aiki wanda aka hada shi da wasu nau'ikan magunguna iri daban-daban na masana'antun daban daban da alamomi karkashin sunaye daban-daban (Zentiva, Vertex, Northern Star da sauransu, dangane da kasar). Kwayar ta zama ta ƙarni na mutum-mutumi ne kuma mai tabbatar da rage ƙwayar lipid.

A kan shelf na kantin magani zaka iya samun magani tare da suna wanda yake cikakke daidai ga abu mai aiki - Simvastatin. Hanyar sakin miyagun ƙwayoyi shine kwamfutar hannu, yana da gefunan da aka zagaye na biconvex, an lullube shi da launi mai haske ko mara kyau. Dangane da maida hankali kan abu mai aiki, ana samun allunan Simvastatin a cikin sigogi da yawa - 10 da 20 a kowace.

Cholesterol a cikin jini na mutum yana samuwa ne kawai ta tsarin da ke daurewar furotin. Irin waɗannan mahadi su ake kira lipoproteins. A cikin jikin akwai wasu nau'ikan waɗannan kwayoyin - babba, ƙanana da ƙarancin girma (HDL, LDL da VLDL, bi da bi). Sakamakon mummunan tasirin cholesterol ya fara bayyana lokacin da ya bayyana a cikin metabolism na lipid. bayyana fa'ida zuwa LDL, abin da ake kira "mummunan" cholesterol.

Sakamakon warkewa na simvastatin an cimma shi da farko ta hanyar rage wannan ɓangaren na lipoproteins (LDL). Ta hana haɗin enzymatic sarkar HMG - Coenzyme A reductase, ƙwaƙwalwar ƙwayar da aka yi nazari ta rage yawan fitsari a cikin sel kuma yana kunna masu karɓa don ƙarancin wadataccen lipoproteins (LDL da VLDL). Don haka, pathogenesis na hypercholesterolemia yana yin tasiri ta hanyoyin guda biyu a lokaci daya - cholesterol ya zama mafi muni daga sel kuma ana samun saurin ficewa daga cikin jini da jiki gaba daya.

Gabanin tushen raguwa daga cikin lahani na mai mai mai kyau, an sake dawo da ma'aunin lipid kuma an tattara haɓakar antagonist, cholesterol mai haɓaka, yana ɗan ƙara girma. A cewar kafofin daban-daban, karuwa a cikin HDL bayan hanya ta warke zai kasance daga 5 zuwa 14%. Simvastatin ba kawai rage mummunar cholesterol ba, amma yana da sakamako vasoconstrictor. Wannan magani yana hana ayyukan dysfunction na bango na jijiyoyin bugun gini, yana ƙara ƙaruwa da sautin sa saboda tasirin antioxidant.

Ofaya daga cikin ka'idojin ci gaban atherosclerosis shine kumburi. Mayar da hankalin kumburi wani bangare ne na wajibi na kowane fifita atherosclerotic a cikin endothelium. Simvastatin yana da tasirin antiproliferative, ta haka ne yake kare endothelium daga sclerotherapy, scarring da stenosis. Yawancin kafofin kimiyya sun bayar da shawarar cewa an samar da tasirin kariya akan maganin endothelium wata daya bayan fara maganin.

Dalilin miyagun ƙwayoyi ana yin shi ne kawai gwargwadon tabbatattun alamu, zaɓin sashi ɗaya ne mutum. Fara amfani yawanci 10 MG kuma, bisa ga marasa lafiya da likitoci, yana da haƙuri sosai. Matsakaicin adadin yau da kullun shine 80 MG. An wajabta shi don yanayin cututtukan cuta mai tsanani. Ga marasa lafiya da cututtukan hanta ko ƙwayar koda, matsakaicin kashi ya ragu kuma shine 40 MG.

Alamu don amfani

An wajabta maganin Simvastatin don maganin yanayin da cututtuka masu zuwa:

• Hypercholesterolemia IIA da nau'ikan IIB bisa ga rarrabuwa na Fredrickson. An wajabta statins idan daidaitawar abincin, salon rayuwa da sauran matakan rashin magunguna basu kawo tasirin warkewar cutar ba. Suna taimakawa tare da tsayayyen ƙwayar cuta a cikin haɗarin haɓakar cututtukan zuciya da jijiyoyin jini daga tushen cututtukan atherosclerosis na hanyoyin jini na zuciya da samuwar plaques.
• Amfani da su ya barata a manyan dabi'un ba kawai gutsuttsuran ƙwayoyin cholesterol ba, har ma da triglycerides Godiya ga aikin aiwatar da Simvastatin, yana yiwuwa a rage yawan TG (triglycerides) a cikin jini da kusan 25%.
• An wajabta Simvastatin a cikin hadadden tsarin kula don magance rigakafin jijiyoyin bugun zuciya da bugun zuciya - shanyewar jiki, bugun zuciya, atherosclerosis. A waje da tushen amfani da wannan magani, matakan cholesterol suna komawa sannu a hankali.

Duk shirye-shiryen cholesterol suna da alamomi na musamman, jerin abubuwan sakamako masu illa da contraindications, saboda haka likita ne kawai zai iya tsara su ta hanyar takardar sayen magani a Latin.

Contraindications

Kamar kowane magani, Simvastatin yana da wasu tsauraran matakan contraindications, wanda yakamata a nisantar dashi. Waɗannan sharuɗɗan sun haɗa da:

• Aiki mataki na pathologies na hepatobiliary tsarin, kazalika da tsawan, ba zai yuwu karuwa a hepatic transaminases asalin da ba a sani ba.
• Cutar myopathic. Saboda myotoxicity, simvastatin na iya tsananta yanayin cututtukan tsarin tsoka, tsokani rhabdomyolysis da gazawar koda bayan shi.
• Shekarun yara. A cikin ilimin yara, babu kwarewa game da amfani da wannan magani. A cikin ilimin kimiyya, babu bayanai kan bayanan martaba na inganci da amincin Simvastatin ga marasa lafiya da ke ƙasa da shekara 18.
• Ciki da shayarwa - babu statin da ake amfani dashi na cholesterol a waɗannan lokutan.

Tare da taka tsantsan, ana wajabta simvastatin ga mutanen da ke shan barasa - daidaituwa da barasa a cikin statins yana da ƙasa, kuma na koda ko na hepatic rashin ƙarfi na iya haɓaka da sauri.

Side effects

Daga gabobin gastrointestinal na ciki na iya samun raunin ciki, cututtukan dyspeptik syndromes, tashin zuciya, amai, da rikodin bargo. Yin amfani da miyagun ƙwayoyi na iya shafar hanta - bisa ga umarnin, karuwa ta wucin gadi a cikin enzymes hanta (ɗaukar jini) mai yiwuwa ne.

Tsarin tsakiya da na jijiyoyin jiki suna iya amsawa ga yin amfani da simvastatin tare da haɓakar ciwo na astheno-vegetative tare da tasirin cephalgia, gajiya, rauni, saurin yanayi, rashin bacci, da bushewa. Seriousarin mummunan sakamako masu illa na Simvastatin sun haɗa da murɗa tsoka (fasciculations), raunin yanayin yanki, canje-canje na zuciya.

Tare da babban hankalin mutum ga aiki ko abubuwan taimako na wannan magani, halayen rashin lafiyan zasu iya haɓaka. Akwai nau'ikan bayyanarsu da yawa, amma bisa ga ƙididdiga, urticaria, eosinophilia, arthritis, angioedema da polymyalgia na rheumatoid genesis na iya samun ci gaba.

Abubuwan da suka shafi fata game da halayen m suna iya zama a cikin nau'in jan-erythematous mai-ƙarami, ƙaiƙayi, da dermatoses. Abubuwan hanawar jini suna da guba ga ƙwayar tsoka, sabili da haka, tare da adadin halaye na mutum ɗaya ko babban sashi, bayyanar myopathies, raɗaɗin ƙwayar tsoka, matakai mai kumburi a cikin tsokoki, rauni da gajiya. A cikin lokuta mafi wuya, rhabdomyolysis yana tasowa.

Sashi da gudanarwa

Dangane da ganewar asali, ana yin simvastatin a cikin sashi na likita wanda aka tsara. Ya bambanta tsakanin ƙaramar warkewa (10 mg) da matsakaicin kullun (80 MG). Ya kamata a sha miyagun ƙwayoyi kafin abinci, sau ɗaya a rana, zai fi dacewa da maraice, a wanke da ruwa mai laushi a zazzabi a ɗakin. Zaɓaɓɓen zaɓi da daidaitawa ana aiwatar da su tare da tazara tsakanin ƙasa da wata ɗaya.

Amsar tambaya ga tsawon lokacin da za a ɗauki Simvastatin don inganta haɓakawa kawai likita zai halarci. Tsawon lokacin karatun ya dogara da ganewar asali, sauyin cutar da alamomin bayanan lipid - LDL, triglycerides, total cholesterol.

Yayin ciki da lactation

Simvastatin yana da teratogenic da tasirin fata. Yana da ikon shiga cikin mahaifa, saboda haka, lokacin da aka tsara shi lokacin daukar ciki, zai iya haifar da ci gaban tayin da cutar. Yarinya mata masu shekaru masu haihuwa waɗanda suke buƙatar shan kwayoyi daga rukuni na statins don dalilai na kiwon lafiya dole ne su bi hanyoyin da suka dace na rigakafi a duk lokacin aikin likita.

A cikin ilimin yara, ba a amfani da maganin ba, tunda babu bayanan asibiti a kan lafiyar aminci da ingancin bayanan Simvastatin ga marasa lafiyar yara.

Tare da aikin hanta mai rauni

Wajibi ne a kula da aikin hanta ba tare da faduwa ba duka biyu kafin fara aikin rage rage kiba da kuma lokacin aikin ta. Ana nuna alamun enzymes na hanta (kwayar magani), kuma ana yin gwaje gwaje da yawa na hanta. Tare da ci gaba da canje-canje a cikin sakamakon gwajin, an dakatar da miyagun ƙwayoyi.

Tare da nakasa aiki na koda

Marasa lafiya da ke fama da raunin ƙwayar cuta ko matsakaitan matsakaici na ƙarancin ƙwayar cutar koda an ba da izinin yin magani, amma an bada shawara su guji matsakaicin matakin. A cikin maganganu masu tsanani na PN (rashin cinikin koda), keɓantar da creatinine ƙasa da 30 ml a minti ɗaya, ko tare da tushen amfani da kwayoyi kamar cyclosporine, fibrates, dinazole, matsakaicin maganin shine 10 MG kowace rana.

Allunan Simvastatin: abin da magani ke taimakawa

Alamu don amfani da miyagun ƙwayoyi sun haɗa da:

• babban hypercholesterolemia (nau'in IIa da IIb) tare da rashin ingancin maganin rashin abinci tare da ƙarancin cholesterol da sauran matakan rashin magunguna (asarar nauyi da aikin jiki) a cikin mutane tare da haɗarin haɓakar haɓakar atherosclerosis,
• hade hypertriglyceridemia da hypercholesterolemia ba a gyara ta hanyar motsa jiki da abinci na musamman ba,
• raguwa a cikin abin da ya faru na cututtukan zuciya (tashin hankali ischemic harin ko bugun jini),
• rigakafin infarction na zuciya na zuciya,
• rage hawan jini na atherosclerosis,
• rage haɗarin hanyoyin farfadowa.

Umarnin don amfani

Ana ɗaukar "Simvastatin" a baki, a maraice 1 lokaci kowace rana a hade tare da adadin ruwa da ake buƙata. Lokacin shan miyagun ƙwayoyi ba ya buƙatar alaƙa da abinci.

Kafin fara maganin, an wajabta mai haƙuri a rage yawan abincin hypocholesterol, wanda ya kamata a lura dashi a duk lokacin da yake jiyya.

Don lura da hypercholesterolemia, maganin da aka ba da shawarar "Simvastatin" ya tashi daga 10 zuwa 80 MG sau ɗaya a rana da maraice. Ga marasa lafiya da wannan maganin, maganin farko da aka ba da shawarar maganin shine 10 MG. Matsakaicin adadin yau da kullun shine 80 MG.

Zaɓin (canji) na kashi ana buƙata a tazara na makonni 4. A cikin mafi yawan marasa lafiya, ana samun ingantaccen sakamako na jiyya yayin ɗaukar maganin a allurai har zuwa 20 mg / rana.

A cikin kula da marasa lafiya da cututtukan zuciya ko babban haɗarin ci gabanta, ingantattun magunguna sune 20-40 mg / day. A wannan batun, shawarar da aka ba da shawarar farko a cikin irin wannan marasa lafiya shine 20 mg / rana. Zaɓin (canji) na kashi ya kamata a yi a tsakanin tsaran makonni 4. Idan ya cancanta, ana iya ƙara yawan zuwa 40 mg / rana.

Ga marasa lafiya da ke shan verapamil ko amiodarone concomitantly tare da Simvastatin, kashi na yau da kullun bai kamata ya wuce 20 MG ba.

A cikin marasa lafiya da matsakaiciyar matsakaici ko ƙananan gazawar maye, kazalika da tsofaffi marasa lafiya, canji a cikin sashi na miyagun ƙwayoyi ba a buƙatar.

A cikin daidaikun mutane tare da hyzycholesterolemia na homozygous, kashi na yau da kullun na Simvastatin shine 80 MG a cikin allurai uku (20 mg da safe, 20 mg da yamma da 40 mg da maraice) ko 40 mg da maraice sau ɗaya a rana.

A cikin marasa lafiya tare da gazawar ƙwayar ƙwayar ƙwayar cuta ko karɓar cyclosporine, gemfibrozil, danazol ko wasu fibrates (ban da fenofibrate), kazalika da nicotinic acid a hade tare da miyagun ƙwayoyi, mafi girman maganin da aka ba da shawarar ya kamata ya wuce 10 MG / rana.

Aikin magunguna

"Simvastatin", umarni don amfani da sanarwa game da wannan, - wakili mai rage yawan lipid wanda aka samo daga kayan aikin Aspergillus terreus shine lactone mara aiki, yana sanya ruwa cikin jiki don samar da wani sinadarin hydroxy acid. Metabolite mai aiki yana hana 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), wani enzyme wanda ke ɗaukar farkon mevalonate daga HMG-CoA.

Tunda canzawar HMG-CoA zuwa mevalonate shine farkon matakin fara aiki a cikin kwayar cholesterol, yin amfani da simvastatin baya haifar da tarin sinadarai masu guba a jiki. HMG-CoA yana da sauƙin haɗuwa da acetyl-CoA, wanda ke shiga cikin ayyukan da yawa na jiki.

"Simvastatin" yana haifar da raguwa a cikin matakan plasma na triglycerides (TG), ƙarancin lipoproteins (LDL), ƙarancin yawan lipoproteins (VLDL) da jimlar cholesterol (a cikin yanayin heterozygous familial da kuma rashin iyali na hypercholesterolemia, tare da cakuda cuta mai ƙarfi a lokacin, lamari mai haɗari) saboda hanawar ƙwayar cholesterol a cikin hanta da haɓaka adadin masu karɓa na LDL akan farfajiyar tantanin halitta, wanda ke haifar da karɓar haɓakawa da catabolism na LDL.

Theara yawan abubuwan lipoproteins mai yawa (HDL) da rage haɓakar LDL / HDL da jimlar cholesterol / HDL. Ba shi da tasirin mutagenic. Farkon bayyanar tasirin shine sati 2 bayan farawar, mafi girman tasirin warkewa yana faruwa bayan makonni 4-6.

Sakamakon ya ci gaba tare da ci gaba da magani, tare da dakatar da jiyya, abubuwan da ke cikin cholesterol ya koma cikin matakin farko.

Side effects

Jiyya na iya haifar da ci gaban sakamako mara amfani kamar:

• anemia
• palpitations
• dyspepsia
• alopecia
• fata tayi
• itching
• rashin bacci
• paresthesia
• ƙwaƙwalwar ƙwaƙwalwar ajiya
• jijiyar wuya
• tsananin farin ciki
• ciwon kai
• na gefe neuropathy,
• m gazawar koda (saboda rhabdomyolysis),
• maganin ciwon huhu
• hepatitis
• rage iko
• rauni
• ciwon ciki
• zawo
• tashin zuciya, amai,
• rashin tsoro
• maƙarƙashiya
• aikin hanta mai rauni,
• myasthenia gravis
• asthenia
• myalgia
• ciwon kai
• Jazzice,
• jijiyar wuya
• rhydomyolysis,
• take hakkin dandano
• fahimta hoto,
• ci gaba da rashin lafiyar hyperensitivity (angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, dermatomyositis, thrombocytopenia, eosinophilia, ƙwararrun ESR, arthritis, arthralgia, urticaria, daukar hoto, zubar fuska, gazawar hanzari).

Analogues na miyagun ƙwayoyi "Simvastatin"

Cikakken analogues akan aiki mai aiki:

1. Simlo.
2. Jahilci.
3. Holvasim.
4. Simvacol.
5. Simvalimite.
6. Zorstat.
7. Aries
8. Simvor.
9. Simgal.
10. Zokor forte.
11. Simvakard.
12. Simvastatin Chaikafarma.
13. Simvastol.
14. Zokor.
15. Simvastatin Zentiva.
16. Mai aiki.
17. Vasilip.
18. Vero Simvastatin.
19. Simvastatin Pfizer.
20. Atherostat.
21. Simvastatin Fereyn.

Rukunin gumakan sun hada da magunguna:

1. Tulip
2. Holvasim.
3. Holetar.
4. Atomax
5. Leskol forte.
6. Mertenil.
7. Aries
8. Pravastatin.
9. Rovacor.
10. Liptonorm.
11. Lovacor.
12. Vasilip.
13. Atoris.
14. Vazator.
15. Zorstat.
16. Cardiostatin.
17. Lovasterol
18. Mevacor.
19. Roxer.
20. Lipobay.
21. Lipona.
22. Rosulip.
23. Tevastor
24. Atorvox.
25. Kanta
26. Lovastatin.
27. Medostatin.
28. Atorvastatin.
29. Leskol.
30. Liprimar.
31. Rosuvastatin.
32. Akorta.
33. Lipostat.
34. Lipoford.
35. Rosucard.
36. Anvistat.
37. Torvazin.
38. Apextatin.
39. Torvacard.
40. Atherostat.
41. Atocord.

Sharuɗɗan hutu da farashi

Matsakaicin farashin Simvastatin (Allunan 10 MG mai lamba 30) a cikin Moscow shine 44 rubles. A cikin Kiev, zaku iya siyan magani (20 mg No. 28) don 90 hryvnias. A cikin Kazakhstan, kantin magunguna suna ba da misalin analog na Vazilip (10 mg No. 28) don 2060 tenge. Yana da matsala samun magani a Minsk. Akwai shi daga kantin magunguna tare da takardar sayan magani.

Game da sake duba marasa haƙuri "Simvastatin" sun bambanta. Wadansu masu sayen sun tabbatar da cewa maganin yana rage matukar rage tasirin cholesterol, amma a lokaci guda suna bayyana nau'ikan maganganu marasa kyau da suka shafi yanayin gaba daya na maganin rashin karfin jini. Marasa lafiya tare da cututtukan cututtukan cututtukan ƙwayar cuta, lura da karuwa da yawaitar fashewa yayin jiyya. Tare da tsawan magani, akwai canji a cikin bayanan lipid don mafi kyau.

An kuma raba ra'ayoyin likitocin. Wasu sun lura cewa maganin ya samu nasarar rage kwayar cholesterol kuma ya zama wata kyakkyawar hanyar hana atherosclerosis. Wasu sun yi imanin cewa maganin yana daɗaɗɗe, ya ba da ƙarancin halayen m, da kuma bayyanar a kan kasuwar magunguna na Atorvastatin da Rosuvastatin, waɗanda sababbin magunguna ne na zamani.

Yin hulɗa tare da wasu kwayoyi

Yin amfani da magungunan antimycotic lokaci guda kamar ketoconazole, itraconazole, yin amfani da erythromycin, cytostatics, babban allurai na Vitamin PP (nicotinic acid) sune contraindication ga alƙawarin Simvastatin. Duk waɗannan magunguna suna da babban abin da ya faru na myopathies da sauran rikice-rikice na tsoka a cikin tasirin sakamako. Lokacin gudanar da su a lokaci guda, ƙwayoyin tsokarsu suna haɓaka, ta haka kusan kusan sau biyu a cikin rhabdomyolysis aukuwa.

Tare da wa'azin layi ɗaya na Simvastatin tare da magungunan anticoagulant (warfarin, fenprocoumone), ya zama dole don saka idanu akan coagulogram na jini a kai a kai, tunda statins suna ƙaruwa da tasirin maganin anticoagulants. Ana aiwatar da canji na sashi ko cirewar magani bayan sarrafa INR.

An ba da shawarar karfi don amfani da ruwan 'ya'yan itace na innabi yayin wani lokacin kula da rage ƙwayar lipid tare da statins. Matsakaicin da aka yarda ya kai miliyan 250 a rana. Wannan sabon abin sha yana dauke da sinadarin inhibitor na CYP3A4, wanda ke canza magungunan gargajiya da magunguna na Simvastatin.

Siffofin aikace-aikace

Simvastatin magani ne wanda ke da yawan magunguna da sakamako masu illa, saboda haka likita ne kawai ke wajabta shi, gwargwadon tabbatattun alamun, kuma ana bayar dashi a cikin kantin magunguna kawai ta hanyar takardar sayan magani. Yayin gudanar da aikin jiyya, ana sanya alamun alamomi na tsarin coagulation na jini (INR, APTT, lokacin coagulation), bayanan lipid, aikin hanta (ALT, enzymes AST) da aikin koda (aikin kwantar da aikin creatinine, CPK).

Farashin magani

Farashin simvastatin matsakaici ne kuma mai araha ga kowane mai haƙuri. Ya danganta da yankin da manufofin sarkar kantin magani, farashin na iya bambanta. A matsakaici, farashin magani a Rasha shine:

• Sashi na 10 MG, guda 30 a kowane fakiti - daga 40 zuwa 70 rubles.
• Sashi 20 MG, guda 30 a kowane fakiti - daga 90 rubles.

A cikin magunguna na Yukren, farashin Simvastatin shine 20-25 UAH da 40 UAH don allurai na 10 da 20 mg, bi da bi.

Analogs na simvastatin

Simvastatin yana da duka rukuni a kasuwar magunguna cikakken analogues - kwayoyin a karkashin wasu sunayen kasuwanci. Wadannan sun hada da Vasilip, Aries, Alkaloid, Simlo, Simvastatin C3, Simgal, Vertex, Simvastol, Zokor. Wadannan kwayoyi sun kasance ma'anar kalmomi kuma ana iya tsara shi dangane da fifikon likitan mutum, yiwuwar kuɗin kuɗin mai haƙuri da kuma halayen mutum dangane da tasirin maganin a kan wani haƙuri.

Menene mafi kyawun simvastatin ko atorvastatin

Simvastatin da Atorvastatin ba abu ɗaya bane. Wadannan magungunan suna cikin tsararraki daban-daban na statins: Atorvastatin - na farko, Simvastatin - na uku. Sun bambanta a cikin abubuwa masu aiki, alamomi, contraindications, ƙimar hulɗa tare da wasu na'urorin likita.

Kowane magani yana da nasa hanyar warkewa da fa'idarsa, don haka bai dace a gwada su ba. Atorvastatin magani ne mai kwazo da aiki da sauri kuma yana da tasiri sosai. Sabili da haka, idan ya cancanta, don hanzarta karɓar canje-canje masu kyau, an ba shi damar. Koyaya, simvastatin, bi da bi, magani ne mai sauƙin ƙwayar cuta wanda ke ba da ƙananan sakamako masu illa kuma an amince dashi don amfani dashi a cikin matakan sassauci na koda da cututtukan hanta, sabanin Atorvastatin.

Mene ne bambanci tsakanin simvastatin da rosuvastatin

Tsakanin simvastatin da rosuvastatin akwai bambanci a cikin abubuwa masu aiki, bayanin martabar tasiri, alamomi, contraindications, tasirin sakamako da kewayon farashi. Ana amfani da Rosuvastatin sau da yawa daga ra'ayi don hanawa a cikin marasa lafiya tare da tarihin ɗaukar nauyi na tsarin zuciya.

Yin Amfani da Bita

Nazarin likitoci da marasa lafiya da ke shan Simvastatin ba su da tsaka tsaki. Likitoci sun lura da larurar da miyagun ƙwayoyi - mummunan tasirin sakamako da wuya a samu daga gare ta, yana dacewa sosai da sauran magunguna. Babban fa'idar maganin shine yiwuwar alƙawarinta tare da cututtukan da ke tattare da kodan ko hanta a cikin bayyanar su mai sauƙi ko matsakaici. Koyaya, a cikin tasiri na simvastatin yana da ƙaranci zuwa analogues na wasu ƙarni na statins, saboda haka, ba a amfani da shi don maganin tashin hankali.

Magunguna da magunguna

Simvastatin yana da babban adadinshi. Ana yin rikodin mafi girman hankali bayan sa'o'i 1.5-2.5, amma bayan sa'o'i 12 yana ragewa da 90%. A cikin sunadaran plasma, bangaren da ke aiki zai iya ɗaure zuwa kashi 95%. Don simvastatin tare da metabolism tasirin da ke tattare da “wucewar farko” halayyar ne a cikin tsarin hepatic, lokacin da, sakamakon hydrolysis, aka samo asalin aiki, beta-hydroxy acid, aka samar. Babban hanyar isarwa shine ta hanji. A cikin tsari mara aiki, 10-15% na abu mai aiki an keɓance ta ta tsarin renal.

Yadda ake ɗaukar simvastatin?

Kullum maganin wannan maganin ga manya shine 1 t. (20-40 mg.) 1 p. kowace rana tsawon minti 30-40. Kafin bacci, shan ruwa mai yawa.

Matsakaicin adadin yau da kullun kada ya wuce 80 MG. (2 t.), Tunda wannan na iya yin tasiri ga lafiyar lafiyar jiki gaba ɗaya.

Hanyar magani da kashi na miyagun ƙwayoyi suna ƙaddara ta wurin halartar likitan halartar cikakke daban-daban ga kowane mara lafiya, gwargwadon tsananin cutarwar wata cuta ta jiki.

Abun ciki da nau'i na saki

Masu kari, mg

Allunan 10/20/40 mg

simvastatin 10/20/40 mg

microcrystalline cellulose 70/140/210

ascorbic acid 2.5 / 5 / 7.5

gelatinized sitaci 33.73 / 67.46 / 101.19

stearic acid 1.25 / 2.5 / 3.75

lactose monohydrate 21/42/63

polyvinyl barasa 2.33 / 4.66 / 6.99

silikion dioxide 0.75 / 1.50 / 2.25

titanium dioxide 0.97 / 1.94 / 2.91

Baƙin ƙarfe baƙin ƙarfe 0.28 / 0.56 / 0.84

jan baƙin ƙarfe 0.19 / 0.38 / 057

Sashi da gudanarwa

Kafin farawa, magani na hypocholesterol wajibi ne. Ana ɗaukar Simvastatin a baki sau 1 da yamma, ana wanka da ruwa, ba tare da la'akari da cin abinci ba. Sashi ya dogara da dalilin saduwa da allunan:

• Hypercholesterolemia - kashi na farko shine 10 MG, mafi girman shine 80 MG. Ana aiwatar da gyaran fuska sau 1 a kowane wata.
• Ischemia, hadarin ci gabanta shine 20-40 MG.
• Maganin Homozygous na hypercholesterolemia - 20 MG sau 3 a rana.
• Kwayar cututtukan ƙwayar cuta na ƙodan - ba fiye da 10 MG kowace rana tare da creatinine na al'ada (ana iya bayyana 3 0.31 ml / min).
• Ga marasa lafiya da ke shan Verapamil, Amiodarone - kashi 20 na yau da kullun.

Umarni na musamman

Kwanakin farko na 1-3 na shan Simvastatin, ana iya ƙaruwa da bilirubin a cikin jini da matakan AST da ALT. A saboda wannan dalili, wajibi ne don gudanar da gwajin duban dan tayi a kowane watanni 3 (lokacin shan 80 MG ko fiye). Jiyya yana tsayawa da zaran enzymes hanta ya wuce al'ada sau 3. Hypertriglyceridemia na nau'ikan 1.4, 5 contraindication ne don amfani da maganin.

Magungunan zai iya haifar da haɓakar rashin lafiyar myopathy, sakamakon abin da ke haifar da rhabdomyolysis, lalacewa aiki na renal. Allunan suna da tasiri duka a cikin hadaddun jiyya tare da jerin abubuwan bile acid, da cikin monotherapy. Za'a iya inganta tasirin allunan ta amfani da tsarin abinci na hypocholesterol. Yin amfani da ruwan 'ya'yan innabi a lokacin jiyya ba a so.

Hulɗa da ƙwayoyi

Sesaukar matakan simvastatin da shan cyclosporine, danazole na iya haifar da rhabdomyolysis. Statin yana haɓaka tasirin maganin cututtukan jini - Warfarin, Fenprokumon, wanda zai iya ƙara haɗarin zubar jini. Digoxin taro yana ƙaruwa a hade tare da cin abinci na statin. An hana shi shan Allunan tare da gemfibrozil. Rashin kamuwa da cutar sankarar mahaifa ya kasance sakamakon haɗuwa da magungunan masu zuwa:

• Nefazodon.
• Amaryaw.
• Clarithromycin
• Labaran.
• Ketoconazole, Itraconazole.
• Fibrates.
• Acidicic acid a cikin manyan allurai.
• Masu hana HIV kariya.

Yawan abin sama da ya kamata

Bayyanar cututtuka na yawan wuce haddi ba takamaiman bayani. Don magani, yana da buqatar jawo vomiting, kurkura ciki. Mai biyo baya shine maganin syndromic tare da lura da sigogin hepatic. Tare da rikitarwa na koda, yin amfani da magungunan diuretic, ana bada shawarar gudanar da maganin sodium bicarbonate. Hemodialysis ba shi da tasiri, amma ana iya yin sa kamar yadda ake buƙata. Tare da rhabdomyolysis, hyperkalemia ya haɓaka, wanda ke buƙatar jiko na ciki na alli chloride da gluconate, insulin tare da glucose.

Sharuɗɗan sayarwa da ajiya

Magungunan Statin magani ne. A wasu kantin magunguna, ba za a buƙatar sayan magani ba. Mai samar da kwamfutar hannu ya ba da shawarar adana magungunan a cikin duhu, wuri mai sanyi a zazzabi na 15 zuwa 25. Ya kamata a kiyaye samfurin musamman a hankali daga yara. Rayuwar rayuwar shiryayye shine watanni 24 daga ranar da aka sake su.

Analogs da maye gurbin magani Simvastatin

Akwai jerin magunguna waɗanda suke da kama da juna a cikin abun da ke ciki da aiki don simvastine. Wadannan magungunan sun hada da:

1. Vasilip cikakke ne tsarin tsarin analog. Ana amfani dashi don kula da hypercholesterolemia, rigakafin ischemia.
2. Simgal - wanda aka yi amfani dashi don hana ci gaban atherosclerosis, infarction na zuciya.
3. Zokor - an wajabta shi zuwa ƙananan ƙwayar plasma cholesterol.
4. Holvasim - shawarar don lura da cakuda hyperlipidemia, ischemia na kullum.
5. Sinkard - wanda aka yi amfani da shi don daidaita wurare dabam dabam, ke rage yiwuwar mutuwa.

A cikin ciki (da lactation)

Simvastatin yana contraindicated a cikin gestation na cikisaboda zai iya haifar da ci gaban mahaifa a cikin jarirai. A lokacin jiyya, da amfani da hana haihuwa. Babu bayanai game da shigarwar abu mai aiki a cikin madara. Koyaya, yana da mahimmanci a tuna cewa akwai babban haɗarin sakamakon tasirin simvastatin akan lafiyar yaro.

Reviews game da Simvastatin (ra'ayin likitoci, marasa lafiya)

Reviews game da Simvastatin a kan tattaunawar sun bambanta. Marasa lafiya sun tabbatar da cewa ƙwaƙwalwar da gaske tana rage ƙwayar cholesterol, amma a lokaci guda suna bayyana halayen ɗabi'a iri daban-daban game da tushen duk hanyar maganin hypocholesterol. Marasa lafiya da ke fama da matsanancin ƙwayar cututtukan ƙwayar cuta suna lura da karuwa da yawaitar fashewar lokacin jiyya. Tare da tsawan magani, akwai canji a cikin bayanan lipid don mafi kyau.

An raba ra'ayoyin likitocin. Wasu sun yi imanin cewa miyagun ƙwayoyi na "tsohuwar mai gadi" kuma ya wanzu da kansa, ba da tsananin halayen halayen ba, da bayyanar a kasuwar magunguna. Atorvastatin da Rosuvastatinwannan yana cikin magungunan sabon zamani. Wasu kuma sun lura cewa magungunan sun sami nasarar rage kwayar cholesterol kuma suna amfani da ingantacciyar hanyar hana atherosclerosis.