Ciwon sukari insipidus (ciwon sukari insipidus, ciwon sukari insipidus syndrome, lat)

Nikita Tyrtov 1 year ago Views:

1 ciwon sukari insipidus (insipidus na sukari, ciwon insipidus na ciwon sukari, insipidus na Latin) wata cuta ce mai saurin kamuwa da cuta (kusan 3 akan) wanda ke da alaƙa da aiki da jijiyoyin jini ko ƙwarƙwar hanji, wanda ke nuna yanayin polyuria (fitowar 6 15 lita na fitsari a rana) da polydipsia (ƙishirwa. )

2 A karo na farko, dandano na fitsari ya raba sukari zuwa mellitus na sukari da ciwon sukari insipidus insipidus Thomas Willis a cikin 1674. An bayyana nau'in dangi na insipidus hypothalamic a cikin 1841 ta Lacombe

3 WILLIS, Thomas (WILLIS, Thomas,) Ba a adana bayanai na kudi game da halin kudin dangin Willis ba, amma a bayyane ba ta cikin masaniyar tattalin arziki, tunda an san cewa Thomas Willis ya je karatu a Oxford a matsayin bawa (dalibin da ke aiki a matsayin bawa na malanta. ) Daga 1646 zuwa 1667, Thomas Willis ya kasance likita a Oxford. Da farko, aikinsa bai yi nasara sosai ba, amma sannu a hankali ya sami wadata sosai. Binciken bayanan haraji ya nuna cewa samun kudin shiga na shekara-shekara shi ne mafi girma a Oxford. Zai yiwu cewa Thomas Willis ya karu da shahararrun likitocin a cikin marasa lafiya ta hanyar sa hannu a cikin Ingila duka, wanda aka sani a ranar 14 ga Disamba 16, 1650, a cikin sake tattara bayanan farko. a cikin 1664 ya buga littafin "Brain Anatomy" wani aiki mai mahimmanci kan ilmin jikin mutum na tsarin juyayi na tsakiya tare da misalai masu ban mamaki. A cikin wannan littafi ne cewa hadaddin jijiyoyin bugun gini a ginin kwakwalwa, wanda a yanzu ake kira da'irar vilisis na arterial, aka fara bayani dalla dalla. Yawancin kuskure suna ba da izini ga marubucin a cikin bayanin wannan halitta ga masanin kimiyyar halittar ɗabi'a da babu shi Vilizius, kodayake a zahiri wannan ya faru ne sakamakon haruffan Turanci na sunan Willis (Willis). Yana ɗayan waɗanda suka kafa kungiyar Masana kimiyya ta Royal.

4 Willis ya bayyana cututtukan guda shida da ilimin kimiyyar likita bai sani ba har zuwa wannan lokacin. Ya bayyana cututtukan fata, meningitis, narcolepsy a cikin marasa lafiya da schizophrenia, cututtukan zuciya da kuma hanyar nasara don maganin ta, shi ne farkon wanda ya bayyana zazzabi bayan haihuwa kuma ya ba ta suna. Idan akai la'akari da fuka-fuka-fuka-fuka, ya nuna farin ciki da tsarin juyayi a matsayin daya daga cikin abubuwan da suka haddasa harin. Da yake magana game da ciwon sanyi, sabanin ra’ayi da aka yarda da shi a wancan lokacin, sai ya bayar da hujjar cewa fitsari ba cuta ce ta mahaifa ba, kuma abubuwan da ke haifar da wannan cutar suna da alaƙa da ƙwaƙwalwar kwakwalwa. Ya bayyana cutar zazzabin cizon sauro da zazzabin cizon sauro, kodayake, farkon shi ne yayi daga baya a shekarar 1659, lokacin da Willis ya ba da lokacin sosai ga karatun zazzabi. Godiya ga wannan aikin, ana tunanin Thomas Willis wanda ya kafa al'adar turanci a cikin cututtukan dabbobi. Willis ya ba da kwatancen asibiti na farko na myasthenia (myasthenia gravis)

Disamba 14, 1650 - Farko da aka ba da takardar tayar da zaune tsaye A wannan ranar, an kashe Anna Green, ana tuhumarta da kisan ɗanta. Wannan yarinyar 'yar kauye mai shekaru ashirin da biyu ta yi aiki a matsayin baiwa a gidan Sir Thomas Reed kuma jikan nata ya ruɗe shi. Bayan da Anna ta sami juna biyu, Jeffrey Reed ya ƙi ta. Naive Anna Green ta ɓoye ajakinta, sabili da haka, a lokacin haihuwar wani yaro da ya mutu, ta ɓoye jikinta. Koyaya, an sami ƙaramin yaro, kuma mummunan yanayinsa ya tashi ya zargi Anna da kisan. An kama ta a tsare, kuma kotu ta yanke mata hukunci wanda ya zama ruwan dare a wancan lokacin - kisan jama'a ta hanyar ratayewa. Bayan an rataye, Anna Green ta ci gaba da rataye a cikin madauki tsawon rabin sa'a. An sanya gawarta a cikin akwatin gawa kuma aka kai ta gidan Dr. William Petty, farfesa a fannin ilimin halittu a Jami'ar Oxford, tunda bisa ga dokar Sarki Charles I (1636), za a canja duk gawawwakin wadanda aka zartar cikin nisan mil 21 na Oxford. Faculty of Medicine.

6 Disamba 14, 1650 - Bayani na farko da ke da farfadowa.Ya kamata a lura da cewa har sai da aka dakatar da karatun 1549 na ilimin halittar jikin likita a jami’ar Oxford. Sarki Edward VI ne ya tilasta wa wannan dakatarwar, abin haushi da takaicin yadda likitocin da suka yi wa fitsarinsa ba su san yadda aka shirya ba. Bisa ga umarnin Sarki Edward VI, an buƙaci kowane ɗalibin likita ya shiga cikin aƙalla takaddun abubuwa huɗu, biyu waɗanda za'ayi su dabam-dabam. Wannan sabuwar bidi'a ta haifar da ainihin "farautar gawarwakin", kuma mafita ga matsalar ta zo ne bayan shekara ɗari bayan godiya, saboda ƙa'idar da aka ambata na Sarki Charles I na 1636. Lokacin da Dr. William Petty, Thomas Willis, Ralph Baturst (Ralph Bathurst,) da sauransu sun taru don wani gwaji, suka buɗe akwatin gawa, sun lura cewa kirjin "gawar" yana motsa motsi, sai sukaji wasu kararrawar abubuwa. Barin nan da nan duk tunani game da gwajin cututtukan da ke tafe, pundits sun fara daukar duk matakan da zasu yiwu don dawo da matar daga rayuwa.

Disamba 7, 1650 - Bayani na farko da ta sake tayar da zaune tsaye Sun cire Anna Green daga akwatin gawa, buɗe haƙoransu da zubar da giya a bakinsu. Wannan ya haifar da farfadowar tari a cikin “gawar”, wanda hakan ya sanya likitocin da suka taru suka ci gaba da dawo da Anna Green rai har ma da sauran kuzari. Sun fara shafawa da shafa hannayenta da kafafunta. Bayan kwata da awa daya, sai likitocin suka sake zubawa a cikin bakin ta wani abin sha mai karfi kuma suka fara yi wa makogwaron dabbar tsuntsu, bayan haka Anna ta bude idanunta na wani dan lokaci. Sannan ta kasance an bled da saki ƙwayoyi 5 na jini. A ci gaba da shafa hannayensu da kafafunsu, likitocin sun sanya filaye a gabobin Anna domin kara yawan jini da ke kwarara zuwa kwakwalwa. Bayan haka, sun sake ba ta wani abin sha mai ƙarfi, kuma sun ba da wani zafi mai ƙanshi don ƙara yawan zafin jikinta. Sannan an sanya Anna Green a kusa da wata matar da ke aiki a matsayin “murhun hura wuta” don ci gaba da sanyaya jikin mai rai da kisan. Bayan sa'o'i goma sha biyu, Anna Green ta sami damar faɗi wasu kalmomi, washegari kuma ta iya amsa tambayoyi. Bayan kwanaki 2, ta sake ƙwaƙwalwa da komai game da komai kafin lokacin aiwatar da hukuncin. Bayan kwanaki 4, ta iya cin abinci mai ƙarfi, kuma bayan wata ɗaya ta warke sarai.

Disamba 14, 1650 - Bayanin sake dawowa na farko A cikin yarjejeniya na dawo da rayuwar Anna Green, Dr. William Petty da Thomas Willis sun bayyana dalla-dalla kuma dalla dalla kan abubuwan da suka lura game da bugun mara lafiyar, yawansa da nau'in numfashi, yanayin farkawa da ƙwaƙwalwa. Makonni biyu bayan kisan, ta fara da tunawa da abin da ya faru a wannan ranar da wani mutum cikin rigar alkyabba, wataƙila mai zartar da hukuncin. An lura cewa fuskarta ta kasance cikin ja da edematous na tsawon kwanaki, kuma ɓarkewar rikicewar tare da buga ƙugiya ta kasance na dogon lokaci a wuya. Bayan murmurewa cikakke, Anna Green ta yafe ta wata shawara ta musamman da kotu da shugaban gidan kurkukun Oxford suka yi, wanda ya yi hankali cikin tunani cewa tunda Ubangiji Allah ya ba Anna Green rai, kotun ba ta da ikon soke hukuncin Madaukaki. Ta koma ƙauyenta, ta sake rayuwa shekara 15 kuma ta haihu da yara uku. Mai yiwuwa wannan yanayi na musamman game da farfadowa na Anna Green ya yi aiki ne a matsayin ƙarfafawa ga likitocin matasa, William Petty da Thomas Willis, don ƙarin karatun likita.

MECHANISM OF AIKIN HARKAR ANTI-DIURETIC

Hanyar aiwatarwa na ADH ya dogara ne akan motsawar juji na shan ruwa a cikin tubules mai ɗorewa da kuma tara shambura na mai ƙoshin koda. Fitsari na farko yana da osmolarity mai kama da plasma. Finalarshe na ƙarshe na fitsari ya dogara da kasancewar ko rashin ADH. A gaban hormone, yawan shan ruwa yana karuwa, kuma ana fitar da fitsari a hankali. Tare da raunin ADH, ana fitar da fitsari mai yawa da aka lalata. Tare da ɓoyewar al'ada na ADH, osmolarity fitsari koyaushe ya fi 300 mOsm / kg kuma yana iya ƙaruwa zuwa 1200 mOsm / kg ko ƙari, tare da rashi, osmolarity fitsari yawanci ƙasa da 200 mOsm / kg. A cikin cikakken rashi ADH da takamaiman ƙarfin fitsari na 1001 g / l, osmolarity na fitsari shine 33.3 mOsm / kg. Don sanin yanayin fitsari, kana buƙatar ninka lambobi biyu na ƙarshe na takamaiman ƙarfin fitsari ta hanyar 33.3.

Ayyukan ADH a matakin salula an gano shi ta hanyar osmo- da baroreceptors, kowane ɗayan tsarin yana aiki da kansa. Ana aiwatar da Osmoregulation a cikin ƙaƙƙarfan iyaka. Canji a cikin plasma osmolality na kawai 1% yana haifar da ɓoyewar ADH, yayin da dangane da ƙimar jini, ADH yana ɓoye lokacin da ƙarar jini ta ragu da kashi 7-15%, duk da haka, tare da saurin raguwa a cikin jini (alal misali, tare da zubar da jini), ƙaddamarwar volumetric ta mamaye ɗayan osmolar. ADH ya shiga cikin kiyaye karfin jini yayin canza matsayin jiki, rage tasoshin jini yayin tsayawa da hana faduwar orthostatic daga haɓaka.

Hanyar aikin kwantar da hankali na ADH shine don kunna ƙwayar calcium - stabodulin hadaddun, ƙara ƙira na cyclic adenosine monophosphate a gaban alli da magnesium ion, da kuma kunna aikin haɗin prostaglandins (PgE-2), wanda, bi da bi, yana hana aikin ADH. Rabin rayuwar ADH yana da kimanin minti 7.3 (minti 1.1-24.1) a duka mutane masu lafiya da marasa lafiya tare da NSD. ADH rashin aiki yana faruwa ne musamman a hanta (50%) kuma a cikin kodan (40%). Kimanin 10% na ADH an fesa a cikin fitsari ba a canzawa.

A matakin koda, hanta, tsarin juyayi na tsakiya (CNS), ƙwayoyin jijiyoyin jini, aikin ADH yana shiga tsakani ta hanyar nau'ikan masu karɓa. A cikin ƙwayoyin tubules na koda, ADH yana aiki ta hanyar V2-baroreceptors, yana riƙe da ruwa, yana ƙarfafa farfadowarsa a cikin kodan. A cikin hanta, ADH yana aiki ta hanyar V1-baroreceptors, yana haifar da rushewar glycogen da kunna ayyukan gluconeogenesis. A cikin tsarin juyayi na tsakiya, ADH ta hanyar V1-baro- da osmoreceptors suna aiki akan tsarin hypothalamic, kai tsaye yana tasiri cortex cortex da halayen halayen. Yana shiga cikin inganta ƙwaƙwalwar ajiya da kuma tattara bayanan da aka adana (misali, yana taimakawa don tunawa da kuma tuna lokacin da ake buƙata). Ta hanyar V3-baroreceptor, ADH yana haɓaka rufin adrenocorticotropic hormone a cikin corticotrophs na adenohypophysis. ADH yana aiki akan tasoshin jini ta hanyar V1-baro- da osmoreceptors, yana haifar da ƙanƙancewar ƙwayar tsoka mai santsi da hana raguwa cikin matsin lamba yayin zubar jini da canji a jikin mutum. Bugu da kari, V1-baroreceptors suna shirin hada sinadaran kwantar da tarzoma, ta hanyar hada platelet.

MAGANIN CIKINSU

A cikin halaye na yau da kullun, ganewar asali na NSD ba shi da wahala kuma yana dogara ne akan halayyar halayyar mai haƙuri na ƙishirwa, yawan amfani da ruwa da yawan urin yawan ruwa, dare da rana. Wani gwajin fitsari na Zimnitsky ya tabbatar da gano cutar tare da diuresis na 320 l / day tare da ƙarancin fitsari - 1001-1155 g / l a cikin duk sassan. Yawan jini na jini wanda yafi girma 300 mOsm / kg da hypernatremia - an gano fiye da 155 meq / l a cikin jini. Thearfin fitsari a cikin yanayin NDS shine 100-200 mOsm / kg 2, 7, 8.

Don bayyana osmolarity na ruwa jiki, akwai sharuɗɗa guda biyu: osmolarity da osmolality. Osmolality shine 12-16 mOsm / kg kasa da osmolarity - matsin oncotic na plasma, wanda ya kasance saboda sunadarai da lipids sun narke a ciki. Ana iya lissafin osmolality ta hanyar: 2x (K + Na) + glucose + urea, inda aka bayyana osmolality a cikin mOsm / kg, K, Na, glucose, urea a mmol / l. Tare da plasma osmolality na 310 mOsm / l kuma oncotic matsa lamba na 12-16 mOsm / l, osmolality shine 275-20 mOsm / kg.

Determinationudurin ADH a cikin ƙwayar magani ba ya da ma'ana, saboda don ganewar asali na NSD, ya fi muhimmanci a sani ba cikakkiyar alamomin nuna ƙwayar hormone a cikin jini ba, amma rabo na osmolality na jini da fitsari. A mataki na gaba, ana yin gwaje gwaje na bambancin gwaji: gwaji tare da hana ruwa don ware polydipsia psychogenic da gwaji tare da desmopressin don ware NSD nephrogenic. Lokacin tabbatar da ganewar asali na NSD na tsakiya, don sanin etiology na cutar, ana yin tasirin maganadisu na magnetic kuma ana nazarin tarihin dangi.

CIKIN SAUKI CIKIN SAUKI

Jiyya na NSD yakamata ya zama etiological. A cikin siffofin bayyanar cututtuka, da farko wajibi ne don gudanar da aikin jiyya na cutar (tumor, kumburi). Koyaya, ba tare da la'akari da dalilin da ya haifar da ci gaban NSD ba, a gaban rashi ADH, isasshen magani yana da mahimmanci.

Babban magani don lura da NSD a halin yanzu desmopressin, wanda aka yi amfani da shi a cikin nau'i biyu: a cikin nau'i na Allunan kuma a cikin nau'i na fesa hanci 10, 11. Desmopressin shine analog na roba na vasopressin, yana da babban aikin antidiuretic a cikin rashin vasopressor kaddarorin. Ayyukanta shine kawai 1/4000 na ayyukan vasopressor na asalin ADH. Ana amfani da miyagun ƙwayoyi a cikin nau'ikan allunan 0.1 da 0.2 MG, yana aiki na 7-12 hours, yana da haƙuri sosai, yana da tasiri sosai, da wuya ya ba da rashin lafiyar. Ana amfani da analogues na roba na vasopressin cikin mata masu ciki, saboda ba sa buƙatar sashi mai yawa kuma kada ku ƙunshi oxytocin, wanda ke ƙara sautin mahaifa. Desmopressin na iya kasancewa mai tasiri a cikin marasa lafiya tare da NSD nephrogenic waɗanda suka riƙe kulawar saura akan ADH.

Lokacin amfani da allurai na miyagun ƙwayoyi, alamomin halayyar riƙewar ruwa a cikin jiki na iya faruwa: ciwon kai mai wahala na lokaci kaɗan, tashin zuciya, hauhawar jini a matsakaici. Game da yawan abin sama da ya kamata, ana lura da ciwon jini na jini, har zuwa maye ga ruwa: zafin ciki, amai, zawo, amai. Waɗannan abubuwan mamakin na lokaci ne na yanayi kuma sun shuɗe tare da ragewa ko cire magani. Maganin farko na desmopressin na manya da yara shine 0.1 mg 3 sau / rana. Sannan ya wajaba a zabi wani matakin yin la’akari da kyautatawar mara lafiya, kamar yadda aka tsaida takamaiman nauyi na fitsari da fitowar fitsari.

Muna ba da misali da zaɓin wani kashi na desmopressin. Mai haƙuri tare da NSD na kwayoyin halitta ya karbi desmopressin 0.2 mg 3 sau / rana, duk da haka, ta ji ba ta da lafiya, ta ƙaru da zazzabi zuwa 37.5-38 ° C ba tare da abin mamakin catarrhal ba, yawan fitowar fitsari yau da kullun ya kasance har zuwa 7-8 l / rana. A cikin gwajin fitsari a cewar Zimnitsky, akwai babban diuresis dare da rana da kuma ƙayyadadden nauyi (1001-1003 g / l) a cikin duk sassan fitsari (Table 1).

Adadin desmopressin ya karu zuwa 0.3 MG sau 3 / rana. Halin rashin haƙuri ba ya canza a zahiri; yanayin tsarin ƙasa yana kasancewa. Diuresis ya ragu kaɗan: daga 7.280 zuwa 6.550 l / rana (Tebur 2).

Increasearin yawan ƙwayar desmopressin zuwa 0.4 mg sau 3 / rana ya haifar da daidaituwa na takamaiman ƙarfin fitsari (Table 3). Duk da gaskiyar cewa diureis din yayi girma - 3,420 l, mai haƙuri bai dame shi ba. A lokaci guda, ta lura da ingantacciyar lafiya da daidaituwar zafin jiki.

Saboda haka, mafi cikakken zaɓi na sashi na miyagun ƙwayoyi a yarda inganta muhimmanci inganta haƙuri da rayuwar rayuwa da objectify da kima na isar da magani.

Desmopressin na cikin gida a cikin allunan 0.1 da 0.2 MG daidai yake da magani na kasashen waje. Desmopressin a cikin nau'in sirin hanci hanci an yi rajista a cikin Federationungiyar Rasha. Kashi 1 na miyagun ƙwayoyi ya ƙunshi 10 μg na abu mai aiki, kashi ɗaya na yau da kullun don amfani dashi a cikin manya shine 1040 μg / day a cikin 1 ko 2 allurai. Tare da kumburi na hanci ko mai rauni na rhinitis, ana bada shawarar gudanar da sublingual management na desmopressin. Lokacin yin sauyawa daga wata yar yar yare zuwa fesa hanci, ana buƙatar karuwar kashi na 1.5 sau.

Jiyya na NSD nephrogenic yafi wahala.Aiwatar da magunguna waɗanda ke nufin rage diureis da ƙishirwa. Wasu kwayoyi suna haifar da tasirin sakamako a cikin marasa lafiya tare da NSD. Misali, maganin thiazide diuretics, wanda a cikin marassa lafiya tare da NSD ya rage tacewa duniya da kuma motsawar sodium tare da raguwar fitowar fitsari da kashi 50-60%. Lura da buƙatar sake sarrafa potassium. Harkokin haɗin gwiwa tare da thiazide diuretics tare da shirye-shiryen potassium yana da tasiri a cikin lura da NSD da ke hade da hauhawar jini na intracranial.

Magungunan sukari na rage sukari na chlorpropamide yana da tasirin maganin rigakafi kuma ana iya amfani dashi tare da haɗin sukari da insipidus na sukari. Antitumor jamiái, neurodepressants, nicotine na iya ta da ɓarnar ADH. Ethyl barasa idan akwai wani NSD yana da sakamako na rikicewa kuma yana rage diuresis. Magungunan rigakafin ƙwayar cuta marasa lalacewa na iya haɓaka sakamakon ADH, kamar yadda toshe PgE2 kuma yana hana shigowa da kodan.

Iri ciwon sukari

A ƙasa, za a gabatar da rarrabuwa na zamani, akan abin da zaku iya ganin yanayin yanayin cututtukan da ke tattare da cutar siga daban-daban. Ana haifar da ciwon insipidus mai yawan ƙishirwa, wanda ke tattare da sakin babban adadin fitsari mara nauyi (har zuwa lita 20 a kowace rana), yayin da matakin glucose na jini ya kasance a cikin iyakokin al'ada.

Ya danganta da ilimin etiology, ya kasu kashi biyu manyan kungiyoyi:

nephrogenic. Farfesa na asali na asali, rashin aikin nephron don tattara fitsari saboda rashin masu karɓa don maganin antidiuretic,
neurogenic. Hypothalamus baya samar da isasshen adadin vasopressin (maganin antidiuretic, ADH), wanda ke adana ruwa a jiki.

Halin ƙwayar cuta na bayan-tashin-hankali ko posthypoxic na cututtukan cututtukan ƙwayar cuta yana dacewa lokacin da, sakamakon lalacewar kwakwalwa da tsarin tsarin hypothalamic-pituitary, bayyanar da rikice-rikicewar ruwa.

Nau'in nau'ikan ciwon sukari:

nau'in 1. lalata kwayoyin halitta na cututtukan endocrine da ke haifar da insulin (hormone da ke rage sukari jini),
nau'in metabolism mai rauni wanda ya raunana asalinsa da yanayin rashin girman yawancin kyallen takarda zuwa insulin,
ciwon sukari. A da, mata masu lafiya suna da matakan glucose da alamomin da ke da alaƙa a lokacin daukar ciki. Bayan haihuwa ta zama warkewar kai.

Akwai nau'ikan nau'ikan nau'ikan da ake samunsu a cikin adadin 1: 1,000,000 a cikin yawan jama'a; suna da sha'awa ga cibiyoyin bincike na musamman:

ciwon sukari da kurma. Cutar cutar ta Mitochondrial, wadda ta danganta da keta hadarin wasu kwayoyin,
latent autoimmune. Halakar ƙwayoyin beta na tsibirin na Langerhans a cikin ƙwayar cuta, wanda ke nuna lokacin balaga,
lipoatrophic. A kan asalin cutar da ke haifar da ci gaba, asrophy of fatcutuwaous ke tsiro,
sabon haihuwa. Hanyar da ke faruwa a cikin yara 'yan watanni 6 na iya zama na ɗan lokaci.
ciwon suga. Halin da ba duk ka'idojin bincike ba na hukunci na ƙarshe,
steroid-jawo. Edara yawan matakan glucose na jini a cikin jini yayin jiyya tare da kwayoyin glucocorticoid na iya haifar da haɓakar insulin.

A mafi yawan lokuta, bayyanar cututtuka ba ta da wuya. Ba a gano siffofin marasa galihu na dogon lokaci saboda bambancin hoton asibiti.

Menene insipidus ciwon sukari?

Wannan halin halin da ake ciki ne kasancewar tsananin ƙishirwa da wucewar fitsari a cikin jiki.

A kan asalin asarar ruwa da lantarki, bushewar jiki da rikitarwa na rayuwa (lalacewar kwakwalwa, zuciya).

Marasa lafiya suna fuskantar rashin jin daɗi sosai, kamar yadda suke haɗe da bayan gida. Idan ba a ba da kulawar likita a kan lokaci ba, kusan koyaushe sakamako mai mutuwa yakan faru.

Akwai nau'ikan 4 na insipidus na ciwon sukari:

tsari na tsakiya. Halin ciki na 'pituitary gland shine yake samar da vasopressin kadan, wanda ke kunna masu karɓar aquaporin a cikin nephrons kuma yana ƙaruwa da sake dawo da ruwa kyauta. Daga cikin manyan abubuwanda ke haifar da lalacewar glandon shine yake faruwa ko kuma cututtukan ƙwayar cuta a cikin ci gaban gland,
siffar nephrotic. Kodan bata amsa vasopressin ba. Mafi yawan lokuta cutar dabi'a ce,
a ciki. Yana da matukar rare, na iya haifar da hadari ga uwa da tayin,
gaurayayyen tsari. Mafi yawan lokuta suna haɗar da fasalin nau'ikan farko biyu.

Jiyya ta ƙunshi shan isashshen ruwa don hana ƙwarya. Sauran hanyoyin warkewa sun dogara da nau'in ciwon sukari. Tsarin tsakiya ko na gestational ana bi da su tare da desmopressin (analog na vasopressin). Tare da nephrogenic, an wajabta thiazide diuretics, wanda a wannan yanayin yana da tasirin sakamako.

Bidiyo masu alaƙa

Yawan sababbin cututtukan cututtukan ƙwayar insipidus shine 3: 100,000 kowace shekara. Tsarin tsakiya yana haɓaka galibi tsakanin shekaru 10 zuwa 20 na rayuwa, maza da mata suna wahala daidai sau da yawa. Sifin koda ba shi da tsayayyen shekaru. Don haka, matsalar ta dace kuma tana buƙatar ƙarin bincike.