Menene banbanci tsakanin Ramipril da analogues, menene ra'ayoyin marasa lafiya suka ce da kuma yadda za ayi amfani da umarnin?

Shafin furotin na Plasma don ramipril shine kashi 73%, ramiprilat shine 56%. Bioavailability bayan kulawar bakin mutum na 2.5-5 MG na ramipril shine 15-28%, don ramiprilat - 45%. Bayan shan ramipril yau da kullun a kashi 5 MG / rana, daidaitaccen ƙwayar ƙwayar cuta ta plasma mai faɗi shine ya kai zuwa rana ta 4.
T1 / 2 don ramipril - 5.1 h, a cikin rarrabawa da kawar da lokaci, raguwa a cikin taro na ramiprilat a cikin jini yana faruwa tare da T1 / 2 - 3 h, to, wani canji tare da T1 / 2 - 15 h ya biyo baya, kuma dogon lokaci na ƙarshe tare da raguwar ramiprilat mai raguwa a cikin plasma da T1 / 2 - 4-5 days. T1 / 2 yana ƙaruwa cikin gazawar na koda. Vd ramipril - 90 l, ramiprilata - 500 l. Kashi 60% na kodan, 40% ta cikin hanji (mafi yawa a cikin hanyar metabolites). Idan akwai rauni na aiki koda, ramipril din da yake fitarwa da metabolites dinsa yana raguwa gwargwadon raguwa a cikin CC, idan akwai aiki hanta mai lalacewa, da canzawa zuwa ramiprilat yana ragewa, kuma idan akwai rashin nasara a zuciya, toshewar ramiprilat yana ƙaruwa sau 1.5-1.8.

Alamu don amfani:
Alamu don amfani da miyagun ƙwayoyi Ramipril sune: hauhawar jini, raunin zuciya, gazawar zuciya wanda ya bunkasa a cikin 'yan kwanakin farko bayan m infarinction myocardial infarction, ciwon sukari da nondiabetic nephropathy, rage hadarin kamuwa da cuta, tashin zuciya da mutuwar jijiyoyin jini a cikin marasa lafiya da ke tattare da haɗarin babbar zuciya, ciki har da marasa lafiya tare da tabbacin cututtukan jijiyoyin zuciya (tare da ko ba tare da tarihin bugun zuciya ba), marasa lafiya waɗanda suka kamu da cututuka na wucin gadi na angioplasty, tiyata na jijiyoyin zuciya, tare da insulin cewa tarihi da kuma a cikin marasa lafiya da na gefe jijiya occlusive cuta.

Hanyar aikace-aikace

Kwayoyi Ramipril shan ta a baki, tare da hauhawar jini - kashi na farko - 2.5 mg sau ɗaya a rana, tare da magani na dogon lokaci - 2.5-20 mg / rana a cikin allurai 1-2. Tare da gazawar zuciya a cikin lokacin bayan-infarction, a farkon kashi na 2.5 MG 2 sau a rana, idan akwai rashin ƙarfi - 5 MG 2 sau a rana, tare da matsanancin rashin ƙarfi ko kan asalin cututtukan cututtukan fata - 1.25 mg sau 2 a rana. A cikin gazawar renal (ƙirar ƙasa da ƙasa da 40 ml / min da matakin creatinine fiye da 0.22 mmol / l), kashi na farko shine 1/4 na kashi na yau da kullun tare da haɓaka hankali zuwa 5 mg / rana (ba ƙari ba).

Side effects

Daga tsarin zuciya: jijiyoyin jini, da wuya - zafin kirji, tachycardia.
Daga gefen tsarin juyayi na tsakiya: dizziness, rauni, ciwon kai, da wuya - rikicewar bacci, yanayi.
Daga tsarin narkewa: zawo, maƙarƙashiya, rashin cin abinci, da wuya - stomatitis, ciwon ciki, ciwon huhun ciki, cututtukan fata.
Daga tsarin numfashi: tari mai bushe, mashako, sinusitis.
Daga tsarin urinary: da wuya - proteinuria, haɓakar haɗuwa da creatinine da urea a cikin jini (galibi a cikin marasa lafiya da ke fama da rauni na aikin koda).
Daga tsarin hawan jini: da wuya - neutropenia, agranulocytosis, thrombocytopenia, anemia.
A ɓangaren alamun alamun gwaje-gwaje: hypokalemia, hyponatremia.
Allergic halayen: fashin fata, angioedema da sauran halayen rashin hankali.
Sauran: da wuya - cramps muscle, rashin ƙarfi, alopecia.

Contraindications

Abubuwan kwantar da hankali don amfani da miyagun ƙwayoyi Ramipril su ne: mai girma na koda hankali na ramipril da sauran hanawar ACE.

Yin hulɗa tare da wasu kwayoyi

Tare da yin amfani da sauƙaƙe na potassium-sparing diuretics (ciki har da spironolactone, triamteren, amiloride), shirye-shiryen potassium, kayan gishiri da kayan abinci don abinci wanda ke dauke da potassium, hyperkalemia na iya haɓaka (musamman a cikin marasa lafiya da ke fama da matsalar aiki na kiɗa), saboda ACE inhibitors yana rage abun ciki na aldosterone, wanda ke haifar da jinkiri a cikin potassium a cikin jikin sabanin tushen iyakance fitar da sinadarin potassium ko kuma karinsa.
Tare da yin amfani da lokaci ɗaya tare da NSAIDs, yana yiwuwa a rage tasirin antihypertensive na ramipril, aiki mara kyau na renal.
Tare da yin amfani da lokaci ɗaya tare da madauki ko thiazide diuretics, ana inganta tasirin antihypertensive. Babban mawuyacin yanayin jijiya, musamman bayan ɗaukar kashi na farko na diuretic, ya zama saboda hypovolemia, wanda ke haifar da karuwa a lokaci na tasirin sakamako na ramipril. Akwai haɗarin hypokalemia. Riskara hadarin lalacewa da aikin keɓaɓɓiyar aiki.
Tare da yin amfani da lokaci ɗaya tare da wakilai waɗanda ke da tasirin sakamako, haɓaka tasirin sakamako mai yiwuwa ne.
Tare da yin amfani da lokaci ɗaya tare da immunosuppressants, cystostatics, allopurinol, procainamide, haɗarin haɓakar haɓakar leukopenia mai yiwuwa ne.
Tare da yin amfani da insulin lokaci guda, wakilai na hypoglycemic, sulfonylureas, metformin, hypoglycemia na iya haɓaka.
Tare da yin amfani da lokaci ɗaya tare da allopurinol, cystostatics, immunosuppressants, procainamide, haɗarin haɓakar haɓakar leukopenia mai yiwuwa ne.
Tare da yin amfani da carbonate na lithium a lokaci daya, haɓakar taro a cikin lithium mai yiwuwa ne.

Yawan abin sama da ya kamata

Bayyanar cututtuka na yawan shan magani Ramipril: matsanancin jijiya na jijiyoyin jini, haɗarin cerebrovascular, angioedema, infarction myocardial, rikicewar thromboembolic.
Jiyya: raguwar kashi ko cikakkiyar cirewar magunguna, lavage na ciki, matsar da mai haƙuri zuwa matsayi na kwance, ɗaukar matakan haɓaka BCC (gudanar da isotonic sodium chloride mafita, watsa wasu ruwa-maye gurbin ruwa), maganin cututtukan: epinephrine (s / c ko iv), hydrocortisone (iv), antihistamines.

Ramipril - abu mai aiki

Sakamakon yana ƙayyade abu mai aiki a cikin abun da ke ciki. Allunan Ramipril suna aiki saboda babban bangaren - ramipril.

Tebur 1. Maganin aiki mai aiki na Ramipril da tasirin sa.

Me yasa magungunan ƙwayoyin cuta tare da ramipril?

Maganin Ramipril ya kafa kansa a matsayin ingantaccen magani mai inganci. Musamman, ana amfani da maganin cikin nasara don:

1. Hawan jini. Kayan aiki, bisa ga umarnin, an wajabta shi don cimma maƙasudin systolic da matsa lamba na diastolic.
2. Farfesa da yawa na cututtukan zuciya. Yadda ake ɗaukar allunan Ramipril, akan menene kuma a cikin me allurai yake dashi kai tsaye ya dogara da cutar.
3. Gudanar da rigakafin cututtukan zuciya da jijiyoyin jini don gano hatsarori.
4. Yin rigakafin mutuwa saboda cututtukan zuciya.

Formaddamar da tsari da abun da ke ciki

Ana samun kayan aiki akan tushen abu guda mai aiki. Daidaito, yawan sha da tsawon rayuwar shiryayye suna haifar da ƙarin abubuwa.

Dangane da umarnin don amfani, miyagun ƙwayoyi Ramipril shima ya ƙunshi:

1. Lactose kyauta. Abun kuma an san shi da sukari na madara. Anyi amfani dashi azaman filletin shirye-shiryen kwamfutar hannu, ƙarin ƙarin tushen makamashi.
2. Povidone. Yana nufin enterosorbents, inganta ƙaddamar da abu mai aiki.
3. Cellulose Anyi amfani dashi a cikin nau'in microcrystalline foda, yana ba kwamfutar hannu damar kula da siffarta.
4. Maganin Stearic acid. Ciki mai cike da kitsen mai, Emulsifier da mai kwantar da hankali.
5. Sanatari Yana inganta sakin jiki da sha daga cikin kayan aiki.
6. Sodium bicarbonate. Wanda aka sani da yin burodi mai narkewa, shine mai tabbatar da ƙarfi.

Ramipril (nau'i na saki - allunan kawai) ana samun su a cikin waɗannan matakan:

1. 2.5 MG Farar fata / kusan farin allunan, cushe a cikin blisters da kwali na kwali. Kowane guda 10, 14 ko 28.
2. Ramipril 5 MG. Allunan fari-fari-mai launin shuɗi, basu rufe ba. A cikin gilashi 10/14/28. An saka blister a cikin kwali. Kowace fakitin ya ƙunshi umarnin don amfani.
3. Ramipril 10 MG. Suna da fararen fata / kusan farin farin, ba mai rufi ba. Allunan suna cikin blisters don 10/14/28 guda. Sanarwa cikin kwali mai kwali tare da umarnin don amfani.

Ramipril, sashi ne wanda kwararre ya ƙayyade, shine takardar sayan magani.

Ramipril-sz

Ramipril-SZ da Ramipril kalmomin juna ne. Bayan mun yi nazarin umarnin don yin amfani da magunguna biyu, zamu iya yanke hukuncin cewa saitin daidai yake da kuma tasiri iri ɗaya.

Nazarin haƙuri yana da yawanci tabbatacce. Musamman:

1. Allunan daga matsin Ramipril suna da sakamako mai sauri. Dangane da umarnin don amfani, bayan mintuna 15 kawai, yanayin mai haƙuri ya fara inganta.
2. Tsawo sakamako. Manufofin sun kasance na awanni 12 zuwa 24.
3. Lokacin da ake rubuta hanya, akwai ci gaba a lafiyar gaba ɗaya da ingancin rayuwa.
4. Abubuwan sakamako masu illa suna da wuya kuma suna da nau'i mai sauƙi.

Wani samfurin da aka daidaita da aka saki a karkashin sunan kasuwanci daban. Pyramil da Ramipril, abin da ya bambanta kawai a wasu abubuwan taimako, magunguna ne masu canzawa. Magungunan yana nuna kyakkyawan sakamako a cikin lura da hauhawar jini. Hakanan an ba da shawarar don:

• nau'ikan cututtukan zuciya na ischemic,
• Ciwon zuciya,
• nephropathy lalacewa ta hanyar ciwon sukari,
• tare da jijiyoyin bugun jini (bugun jini, kamuwa da cuta),
• don rigakafin wasu cututtuka da mutuwa daga gare su.

Cikakken bayani kan menene Pyramil, yadda ake ɗaukar shi daidai, kuma a cikin wane yanayi ne aka haramta, ya ƙunshi umarnin amfani.

Kyakkyawan magani da aka yi amfani da shi don bi da yawancin cututtukan cututtukan cuta. Yana da sakamako mai aiki tare da abun da ke da kusanci. Dangane da binciken da aka gudanar a cikin shekarun 1990s, matsin lamba ya fi sauran ƙwayoyi da yawa yawa (misali, enalapril). Mahimmancin rashi na Hartil sun haɗa da farashin sa. A matsakaici, miyagun ƙwayoyi za suyi tsada sau 3-4 mafi tsada fiye da Ramipril (alamomi don amfani da kudade daidai suke). An hana:

• mata masu shirin daukar ciki, masu juna biyu ko masu shayarwa,
• yara da matasa da ke ƙasa da shekara 18.

Marasa lafiya fiye da shekaru 65 ya kamata su ɗauki Hartil da taka tsantsan. Dole kwaya ta farko ta bugu a karkashin kulawar kwararrun.

Wannan ingantaccen tsari ne na maganin. Morearin tasirin da aka ambata shine saboda kasancewa a cikin abun da keɓaɓɓen ƙunshi - hydrochlorothiazide. Abubuwan yana taimakawa rage karfin jini tare da ƙara ƙarancin diuresis.

Dangane da umarnin don amfani, ana bada shawarar maganin don marasa lafiya da ke rigakafin cutar ta ACE inhibitor monotherapy. Don cimma sakamako mai iya ganuwa, an tsara tsarin kulawa da Hartila-D.

Wanene ya samar da ƙwayar asali?

Akwai samfuran da yawa waɗanda ke samar da magani tare da abun da ke kama, amma a ƙarƙashin sunaye daban-daban. Ramipril asalin magani ne wanda aka ƙera a Rasha. Kamfanin samar da magunguna na Tatkhimpharmpreparaty yana cikin Kazan kuma ya kwashe shekaru 85 yana aiki. Kamfanin yana samar da nau'ikan magunguna sama da 100 kuma yana ba da tabbacin lafiyar kayan. A cikin gidan yanar gizon kamfanin zaku iya samun cikakkun umarnin umarnin don amfani.

Alamu don amfani

Magungunan Ramipril, umarnin don amfani wanda ya ƙunshi cikakkun jerin alamomi, an wajabta shi ne bayan gwaji da kuma ganewar asali. Ana bada shawarar kayan aiki don:

1. Hawan jini. Ramipril yana taimakawa rage matsin lamba a farkon tsarin cutar, wanda ya tashi daban da sauran cututtukan. Hakanan yana da tasiri ga hauhawar jini na biyu wanda ya haifar da rikice-rikice na tsarin kulawa.
2. Ciwon zuciya mai rauni. Ana amfani dashi azaman wani ɓangare na magani hade.
3. Cututtukan zuciya da na jijiyoyin zuciya, ciki har da bayan rashin karfin myocardial infarction.
4. Gudanar da jiyya a cikin marasa lafiya waɗanda suka tsira daga tiyata na jijiyoyin bugun jini (ƙetaren tiyata, angioplasty, da sauransu).
5. Marasa lafiya waɗanda ke fama da raunuka na jijiyoyin bugun jini, gami da tarihin bugun jini.
6. Gudanar da rigakafin cututtukan cututtukan jini da zuciya, don hana mutuwa.
7. Cutar sukari

Abin da ke tantance karfin jini na mutum

Umarnin don amfani

Kafin shan miyagun ƙwayoyi, dole ne ka fahimci kanka da shawarar mai ƙira. Umarnin don amfani ya ƙunshi jerin dalilan hana amfani da miyagun ƙwayoyi. Wato:

1. Cututtukan cututtukan da ke tasirin jijiyar jiki (lupus erythematosus, scleroderma).
2. Kowace rashin haƙuri a cikin abubuwan hade, gami da lalacewar lactose sha.
3. Ganin cutar Quincke edema ko Quincke edema wanda ke faruwa a baya bayan ɗaukar kudade dangane da ramipril.
4. Cutar Hypotonic.
5. Ciwon hanta ko aikin koda.
6. Stenosis na jijiya daya / biyu na jijiya, ƙwarewar ƙwayar cutar koda.
7. Decompensated zuciya gazawar.
8. Syntarfin hadaddun aldosterone.
9. Yi amfani da a cikin marasa lafiya da ciwon sukari suna karɓar aliskeren da sauransu.

An nuna duk jerin abubuwan a cikin umarnin don amfani. Kar a manta da karanta bayani kafin amfani da magani.

Yawan maganin yana dogara da cutar na yanzu.

Tebur 2. Kimanin yawan maganin Ramipril ne na cututtuka daban-daban.

Dangane da sabon binciken da aka bayar a cikin umarnin don amfani, miyagun ƙwayoyi ya kamata su fara shan tare da 1.25 MG kowace rana. Koyaya, yanke shawara akan takamaiman mai haƙuri likita ne ya yanke shi. Cikakken tsari an nuna alamun a cikin tattaunawar.

Amfani da barasa

Kada a haɗu da miyagun ƙwayoyi tare da barasa saboda wasu dalilai:

1. Barasa yana haifar da tasirin ƙwayoyi. Rage saukar karfin jini na iya haifar da rikice-rikice ko ma mutuwar mai haƙuri.
2. Asedara yawan guba. A miyagun ƙwayoyi da ethanol guba jiki, yin kara har abada, kuma kai ga cuta daban-daban.

Shaidar marasa lafiya suna shan maganin matsa lamba

Ra'ayoyin masu amfani da yanar gizo bazai zama babban ma'auni ba don kimanta maganin. Zabi na miyagun ƙwayoyi ne zalla mutum. Ramipril, sake dubawa wanda ya ƙunshi bayanan saɓani, ana bada shawarar don:

• saurin aiwatarwa
• tsawon tasiri
• da yiwuwar guda kashi,
• m farashin
• da damar siye a kowane kantin magani.

Sauran marasa lafiya sun ba da rahoton cewa maganin ba shi da tasirin da ake so bayan shan shi ko kuma haifar da sakamako masu illa. Mafi yawan lokuta mutane sukanyi gunaguni game da:

• bushe zafi tari,
• tabarbarewa a cikin ingancin rayuwar jima'i,
• ƙara yin gumi.

Recipe na Latin

Ramipril (girke-girke a Latin - Tab. Ramiprili) an samar da shi daga kamfanoni da yawa. Irin wannan ƙaddara zai ba ku damar ayyana kayan aiki ɗaya ko da a ƙarƙashin sunayen cinikayya daban-daban (daidaitattun kalmomi). Koyaya, siyan magani ba tare da yardar wani kwararre ba shi da daraja.

Akwai wasu magunguna da yawa waɗanda suke da tasirin warkewa iri ɗaya. Ramipril, analogues wanda aka wakilta sosai, ana iya maye gurbinsu ta yarjejeniya da likita.

La'akari da Ramipril da Enalapril, wanda yafi kyau wuya a faɗi tabbas. Magunguna suna da bambance-bambance da yawa:

1. Abu mai aiki. Maganin aiki mai aiki a cikin abubuwan da ake magana da shi na enalapril shine enalapril.
2. Ana ganin Enalapril a matsayin mara ƙarancin kwayoyi, amma wannan ra'ayi yana kan batun. A cikin marasa lafiya daban-daban, sakamakon na iya zama akasin haka.
3. Kudinsa. Enalapril yana da ɗan rahusa fiye da maganin analog.

Lisinopril

Dangane da wani binciken kasa da kasa da NORA ta yi, Lisinopril ba shi da tasiri kamar analog ɗin shi.

Yin la'akari da Ramipril da Lisinopril, wanda yake mafi kyau kuma mafi inganci, masana kimiyya sun yanke shawara cewa magani na farko yana da ikon inganta halayyar rayuwa da haƙuri na mai haƙuri tare da cututtukan zuciya da na jijiyoyin bugun gini. Binciken ya shafi mutane dubu 10.

Perindopril

Perindopril yana da alaƙar rauni, wannan gaskiya ne don kashi na farko. Anyi shawarar sanya shi idan akwai ƙarancin raunin jijiyoyin jini. Mafi sau da yawa ana amfani dashi azaman ɓangaren maganin warkewa a hade tare da diuretics. Kwatanta Ramipril da Perindopril, wanda ya fi kyau kuma mafi inganci, yawancin likitocin sun yi maganin farko. Koyaya, yanke shawara ta ƙarshe ta dogara da takamaiman shari'ar.