Umarnin don amfani da miyagun ƙwayoyi

Magani don subcutaneous management - 1 ml:

abubuwa masu aiki: exenatide - 250 mcg,
magabata: sodium acetate trihydrate, acid na glacial, mannitol, metacresol, ruwa d / i.

A cikin almalin sirinji tare da gurneti na 1.2 ko 2.4 ml, a cikin fakitin allon alkalami 1 alkalami.

Mafita don sc gwamnati babu launi, babu gaskiya.

Damuwa. Bayan sc አስተዳደር na exenatide a cikin kashi 10 μg ga marasa lafiya da ke da nau'in ciwon sukari guda 2, ana cire hanzarin exenatide kuma bayan awa 2.1 ya kai Cmax, wanda shine 211 pg / ml. AUCo-inf shine 1036 pg × h / ml. Lokacin da aka fallasa shi daga exenatide, AUC yana ƙaruwa gwargwadon karuwar kashi daga 5 zuwa 10 μg, yayin da babu haɓaka gwargwado a Cmax. An lura da irin wannan sakamako tare da gudanarwa na juzu'in ciki na exenatide a ciki, cinya ko hannu.

Rarraba. Apparentwaƙwalwar bayyana rarraba (Vd) na exenatide bayan sc gudanar shine 28.3 lita.

Metabolism da excretion. Exenatide yana daɗaɗawa ta hanyar ƙirar ɗumbin ɗumbin ruwa wanda ya biyo bayan lalacewa ta kariya. Cirewar waje shine 9.1 l / h. Tarshen T1 / 2 shine sa'o'i 2.4. Waɗannan halayen magunguna na exenatide suna da 'yanci. An ƙididdige yawan abubuwan da ake amfani da su na exenatide kamar sa'o'i 10 bayan dosing.

Pharmacokinetics a cikin lokuta na musamman na asibiti. A cikin marasa lafiya da ke fama da rauni na matsakaici ko matsakaici matsakaici (Cl creatinine 30-80 ml / min), sharewar exenatide ba ta bambanta da yarda a cikin marasa lafiya da keɓaɓɓen aikin na koda, saboda haka, ba a buƙatar daidaita sigar magunguna ba. Koyaya, a cikin marasa lafiya waɗanda ke fama da ƙarshen ƙarancin ƙarancin ƙarancin yanayin da ke fama da dialysis, an rage matsakaicin darajar zuwa 0.9 l / h (idan aka kwatanta da 9.1 l / h a cikin batutuwa masu lafiya).

Tunda exenatide ne kodan ke fitar da koda, an yi imanin cewa aikin hanta mai rauni ba ya canza haduwar exenatide a cikin jini.

Shekarun baya tasiri da halayen magunguna na exenatide. Sabili da haka, ba'a buƙatar marasa lafiya tsofaffi don aiwatar da daidaitawa na kashi.

Ba a yi nazarin magungunan magunguna na exenatide a cikin yara ba.

Babu bambance-bambance mai mahimmanci na asibiti tsakanin maza da mata a cikin magungunan magungunan exenatide.

Magungunan likitancin gargajiya na exenatide a cikin wakilan jinsuna daban-daban kusan ba su canzawa. Gyara daidaitawa dangane da asalin kabila ba'a buƙata ba.

Babu wata sananniyar dangantaka a tsakanin tsarin jikin mutum (BMI) da kuma magungunan kashe magunguna. Gyara daidaitawa dangane da BMI ba a bukatar shi.

Exenatide (Exendin-4) wani abu ne wanda yake rikakken ciki ne kuma shine amidopeptide 39-amino acid. Abubuwan da ke faruwa, kamar su gluptagon-kamar peptide-1 (GLP-1), haɓaka ƙwayar insulin-glucose, haɓaka aikin beta, rage yawan glucagon ɓoyewa da rage jinkirin motsa jiki bayan sun shiga babban jini daga hanji. Exenatide wani abu ne mai karfi wanda yake inganta kwayar cutar insulin kuma yana da sauran tasirin da ake amfani da shi don inganta shi, wanda ke inganta kulawar glycemic a cikin marasa lafiya da ke dauke da ciwon sukari na 2.

Tsarin amino acid na exenatide wani bangare yana dacewa da jerin GLP-1 na mutum, sakamakon abin da ya ɗaure kuma yana karɓar masu karɓa na GLP-1 a cikin ɗan adam, wanda ke haifar da karuwar haɗarin glucose da kuma ɓoye insulin daga ƙwayoyin beta na pancreatic tare da halartar cyclic adenosine monophosphate (AMP) ko / sauran hanyoyin sakonni na ciki. Exenatide yana ƙarfafa sakin insulin daga sel beta a gaban abubuwan haɓaka glucose.

Exenatide ya bambanta a cikin tsarin sunadarai da aikin pharmacological daga insulin, abubuwan asali na sulfonylurea, abubuwan D-phenylalanine da meglitinides, biguanides, thiazolidinediones da inhibitors na alpha-glucosidase.

Exenatide yana inganta sarrafa glycemic a cikin marasa lafiya da ke dauke da ciwon sukari na 2 saboda hanyoyin da aka lissafa a ƙasa.

A cikin yanayin hyperglycemic, exenatide yana haɓaka ƙwayar glucose mai dogara da insulin daga ƙwayoyin beta na pancreatic. Wannan asirin insulin ya daina aiki yayin da tattarawar glucose a cikin jini ke raguwa kuma yana kusantowa al'ada, ta haka zai iya rage haɗarin haɗarin hawan jini.

Sirrin insulin a cikin mintina 10 na farko, wanda aka sani da "kashi na farko na amsawar insulin", ba ya cikin musamman a cikin marasa lafiya da ke dauke da ciwon sukari na type 2. Bugu da kari, asarar kashi na farko na amsawar insulin shine farkon nakasa aikin kwayar beta a cikin nau'in ciwon sukari na 2. farfadowa ko inganta haɓaka duka na farko da na biyu na amsawar insulin a cikin marasa lafiya da ke fama da ciwon sukari na 2.

A cikin marasa lafiya masu fama da cutar sukari na 2 na ciwon sukari a cikin asalin cututtukan hyperglycemia, gudanar da aikin exenatide yana hana ɓarnatar da yawan glucagon. Koyaya, exenatide baya tsoma baki tare da amsawar glucagon na yau da kullun zuwa hypoglycemia.

An nuna cewa sarrafa kayan abinci wanda ke haifar da raguwar ci da kuma rage abinci, yana hana motsin ciki, wanda hakan ke haifar da koma baya cikin lalacewarsa.

A cikin marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na sukari, exenatide far a hade tare da shirye-shiryen metformin da / ko shirye-shiryen sulfonylurea yana haifar da raguwar glucose jini, postprandial jini glucose, da kuma glycosylated hemoglobin index (HbA1c), don haka inganta sarrafa glycemic sarrafawa a cikin waɗannan marasa lafiya.

Pharmacodynamics

Exenatide yana inganta sarrafa glycemic a cikin marasa lafiya da ke dauke da ciwon sukari na 2 saboda hanyoyin da aka lissafa a ƙasa.

An nuna cewa sarrafa kayan abinci wanda ke haifar da raguwar ci da kuma rage abinci, yana hana motsin ciki, wanda hakan ke haifar da koma baya cikin lalacewarsa.

Pharmacokinetics

Damuwa. Bayan s / c gwamnatin exenatide a cikin kashi 10 μg ga marasa lafiya da ke fama da nau'in ciwon sukari na 2, mikakken exenatide yana da sauri kuma bayan awa 2.1 ya kai C_max wanda shine 211 pg / ml. Auc_o-inf shine 1036 pg × h / ml. Lokacin da aka fallasa shi daga exenatide, AUC yana ƙaruwa gwargwadon karuwar kashi daga 5 zuwa 10 μg, yayin da babu haɓaka daidaituwa a C_max. An lura da irin wannan sakamako tare da gudanarwa na juzu'in ciki na exenatide a ciki, cinya ko hannu.

Rarraba. A bayyane ƙarar rarraba (V_d ) exenatide bayan sc አስተዳደር shine lita 28.3.

Metabolism da excretion. Exenatide yana daɗaɗawa ta hanyar ƙirar ɗumbin ɗumbin ruwa wanda ya biyo bayan lalacewa ta kariya. Cirewar waje shine 9.1 l / h. Karshe T_1/2 yana awoyi 2.4. Wadannan halayen magunguna na exenatide suna da doseancin-kashi. An ƙididdige yawan abubuwan da ake amfani da su na exenatide kamar sa'o'i 10 bayan dosing.

Pharmacokinetics a cikin lokuta na musamman na asibiti. A cikin marasa lafiya da ke fama da rauni na matsakaici ko matsakaici matsakaici (Cl creatinine 30-80 ml / min), sharewar exenatide ba ta bambanta da yarda a cikin marasa lafiya da keɓaɓɓen aikin na koda, saboda haka, ba a buƙatar daidaita sigar magunguna ba. Koyaya, a cikin marasa lafiya waɗanda ke fama da ƙarshen ƙarancin ƙarancin ƙarancin yanayin da ke fama da dialysis, an rage matsakaicin darajar zuwa 0.9 l / h (idan aka kwatanta da 9.1 l / h a cikin batutuwa masu lafiya).

Tunda exenatide ne kodan ke fitar da koda, an yi imanin cewa aikin hanta mai rauni ba ya canza haduwar exenatide a cikin jini.

Shekarun baya tasiri da halayen magunguna na exenatide. Sabili da haka, ba'a buƙatar marasa lafiya tsofaffi don aiwatar da daidaitawa na kashi.

Ba a yi nazarin magungunan magunguna na exenatide a cikin yara ba.

Babu bambance-bambance mai mahimmanci na asibiti tsakanin maza da mata a cikin magungunan magungunan exenatide.

Magungunan likitancin gargajiya na exenatide a cikin wakilan jinsuna daban-daban kusan ba su canzawa. Gyara daidaitawa dangane da asalin kabila ba'a buƙata ba.

Babu wata sananniyar dangantaka a tsakanin tsarin jikin mutum (BMI) da kuma magungunan kashe magunguna. Gyara daidaitawa dangane da BMI ba a bukatar shi.

Contraindications

rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi,

nau'in 1 mellitus na ciwon sukari ko kasancewar cutar ketoacidosis mai ciwon sukari,

mai tsanani gazawar koda (Cl creatinine - gastrointestinal fili tare da concoitant gastroparesis,

lactation (shayarwa),

yara 'yan kasa da shekaru 18 (aminci da ingancin magani a cikin yara ba a kafa su ba).

Side effects

Abubuwan da ba su dace ba wanda ya faru sau da yawa fiye da a cikin keɓaɓɓun lokuta an jera su daidai da gradation mai zuwa: sau da yawa - ≥10%, sau da yawa - ≥1%, amma tsarin juyayi na tsakiya: sau da yawa - dizziness, ciwon kai, da wuya - nutsuwa.

Daga tsarin endocrine: sau da yawa sau da yawa - hypoglycemia (a hade tare da abubuwan da keɓaɓɓe na sulfonylurea), sau da yawa - ji na rawar jiki, rauni, hyperhidrosis.

Allergic halayen: da wuya - kurji, itching, angioedema, musamman rare - anaphylactic dauki.

Sauran: sau da yawa - amsawar fata a wurin allura, da wuya - rashin ruwa (da ke hade da tashin zuciya, amai da / ko zawo). Yawancin lokuta na ƙara yawan coagulation jini (INR) an ba da rahoto tare da yin amfani da warfarin da exenatide lokaci guda, wanda wani lokacin yana tare da zub da jini.

Sakamakon gaskiyar yawan hypoglycemia yana ƙaruwa tare da haɗin gwiwa na shirye-shiryen Baeta ® tare da abubuwan da suka samo asali na sulfonylurea, ya zama dole don bayar da ragi don rage yawan abubuwan da keɓaɓɓe na ƙwayoyin sulfonylurea tare da haɗarin haɗarin hypoglycemia. Yawancin sassan cututtukan hypoglycemia a cikin ƙaruwa sun kasance masu sauƙi ko matsakaici kuma an dakatar da su ta hanyar shan abinci na carbohydrate na baka.

Gabaɗaya, tasirin sakamako masu sauƙi ne ko matsakaici a cikin rauni kuma baya haifar da janyewar jiyya. Mafi sau da yawa, tashin zuciya mai laushi na matsakaici ko matsakaici mai ƙarfi ya dogara da kashi kuma ya ragu cikin lokaci, ba tare da tsangwama ga ayyukan yau da kullun ba.

Haɗa kai

Ya kamata a yi amfani da Bayeta ® tare da taka tsantsan a cikin marasa lafiya da ke shan maganganu na baki wanda ke buƙatar ɗaukar hanzari daga hancin gastrointestinal, saboda Baeta ® na iya jinkirta kwashewa daga ciki Ya kamata a shawarci marassa lafiya su sha magungunan baka, sakamakon abin da ya danganci maida hankali ne garesu (misali maganin rigakafi), aƙalla 1 sa'a kafin aiwatar da maganin. Idan irin waɗannan kwayoyi dole ne a sha tare da abinci, to ya kamata a ɗauke su a lokacin waɗancan abincin lokacin da ba a sarrafa magunguna.

Tare da gudanarwa na lokaci guda na digoxin (a kashi na 0.25 mg 1 lokaci / rana) tare da Bayeta ®, C yana raguwa._max digoxin da kashi 17%, da kuma T_max yana ƙaruwa da awa 2.5. Duk da haka, tasirin magunguna gaba ɗaya a ma'aunin canji baya canzawa.

A waje da tushen gabatarwar miyagun ƙwayoyi Bayeta ® AUC da C_max lovastatin ya ragu da kusan 40 da 28%, bi da bi, da T_max Haɓakawa da Bayeta ® tare da HMG-CoA reductase inhibitors ba su haɗu da canje-canje a cikin abubuwan haɗin jini (HDL cholesterol, LDL cholesterol, jimlar cholesterol da triglycerides).

A cikin marasa lafiya da hawan jini ko sassauyawar jijiya mai karfin jini wanda aka inganta ta hanyar lisinopril (5-20 mg / day), Bayeta ® bai canza AUC da C ba_max lisinopril a ma'auni. T_max lisinopril a ma'auni ya karu da awa 2. Babu canje-canje a cikin alamu na matsakaita na yau da kullun SBP da DBP.

An lura cewa tare da gabatarwar warfarin mintuna 30 bayan shiri Bayeta ® T_max Ya ƙaru da kimanin awa biyu .. Canjin canji na asibiti C_max kuma ba a lura da AUC ba.

Ba a yi nazarin yin amfani da Bayeta ® hade da insulin ba, abubuwan D-phenylalanine, meglitinides ko alpha-glucosidase inhibitors.

Sashi da gudanarwa

S / c zuwa cinya, cinya, ko goshi.

Maganin farko shine 5 mcg, wanda ana gudanar dashi sau 2 / rana a kowane lokaci yayin minti 60 na safe kafin abincin safe da maraice. Kada ku sarrafa magani bayan cin abinci. Idan aka rasa allura na miyagun ƙwayoyi, magani yana ci gaba ba tare da canza sashi ba.

Wata daya bayan fara magani, ana iya ƙara kashi na miyagun ƙwayoyi zuwa 10 mcg sau 2 / rana.

Idan aka haɗu da metformin, thiazolidinedione, ko tare da haɗuwa da waɗannan magungunan, kashi na farko na metformin da / ko thiazolidinedione ba za a iya canza su ba. Game da haɗuwa da Bayeta ® tare da abubuwan da aka samo na sulfonylurea, ana iya buƙatar rage kashi ɗaya na maganin sulfonylurea don rage haɗarin cututtukan jini.

Umarni na musamman

Ba da shawarar a cikin / cikin ko a / m na magani ba.

Bayeta ® bazai amfani dashi ba idan an samo barbashi a cikin mafita ko kuma idan mafita yana da gajimare ko yana da launi.

Magungunan rigakafi don wucewar jiki na iya bayyana yayin jiyya tare da Bayeta ®. Koyaya, wannan baya tasiri mita da nau'in sakamako masu illa.

Yakamata a sanar da marassa lafiya cewa magani tare da Bayeta lead na iya haifar da raguwar ci da / ko nauyin jikin mutum kuma saboda waɗannan sakamakon babu buƙatar canza tsarin sashi.

Marasa lafiya kafin fara jinya tare da Bayeta ® ya kamata su san kansu tare da Jagora don amfani da alkalami mai suturar da aka haɗa tare da miyagun ƙwayoyi.

Sakamakon binciken gwaji

A cikin binciken kwaskwarima a cikin beraye da berayen, ba a gano wani tasirin carcinogenic na exenatide ba. Lokacin da aka ba berayen kashi 128 sau na kashi a cikin mutane, an lura da adadi a cikin ƙwayar C-cell ta adenomas ba tare da wasu alamun cutar ba, wanda ke da alaƙa da haɓaka haɓaka rayuwar dabbobin gwaji da ke karɓar exenatide.

Anatomical-warkewa-sunadarai rarrabuwa (ATX)

Anatomical-warkewa-sunadarai rarrabuwa (anatomical-warkewa-sunadarai, ATX) - Tsarin magungunan kasa da kasa. Babban dalilin ATX shine samar da ƙididdiga akan yawan ƙwayoyi.

A cewar ATX, Bayeta miyagun ƙwayoyi nasa ne sashin "Sauran magunguna don maganin ciwon sukari mellitus".

Tsarin ilimin rayuwa (ICD-10)

Classungiyoyin Cutar Kasa da Internationalasa na Gyara na Goma (ICD-10) kayan aiki ne na kimantawa a fannin kula da lafiya, magani, annobar cuta, da kuma nazarin yanayin lafiyar jama'a gaba ɗaya. Dangane da ICD-10, Bayeta (Exenatide), ana iya amfani da maganin don cututtukan da ke gaba:

Ciwon sukari wanda ba shi da insulin-insulin-mellitus (nau'in ciwon sukari na 2).

Baeta mai aiki

Exenatide - incretinomimetic, wani kwalaben roba da aka samo sakamakon haɗin gwiwa na magungunan Amylin da Eli Lilly da Co. Ana fitar da Exenatide daga ƙwayar gilashin dutsen Gila (Hila lizard), wacce ke zaune a Arizona, Amurka. A wani lokaci, masanan ilmin halitta sun jawo hankali - Khilali na Khila sun sami damar dogon lokaci (har zuwa watanni hudu) suyi ba tare da abinci ba. Daga baya, masana kimiyyar da suka yi nazarin wannan abin mamakin sun gano cewa, ana kashe maganin waɗannan dabbobi masu rarrafe a zamanin “azumi” kuma ya daina aiki. Exendin-4 (Exenatide), wanda akan inganta aikin Bayeta, yana taimakawa masu narkewar abinci.

Gross Formula Exenatide: C184 H282 N50 O60S.

Sauran hujjoji masu ban sha'awa game da magunguna za a iya samun su a cikin sashin da ya dace na tashar.

Fitar saki da sigar maganin Baeta

Baeta yana samuwa a cikin nau'in siren sirinji a cikin matakai biyu:

bayani don ƙananan ƙwayoyin cuta na 250 μg / ml, kabad mai nauyin 1.2 ml a cikin alkalami mai siɓa (5 μg),
bayani don ƙananan ƙwayoyin cuta na 250 μg / ml, kabad mai nauyin 2.4 ml a cikin alkalami mai sirinji (10 μg).

Yawancin maganin da aka fi amfani dasu a cikin magungunan Bayeta shine 1.2 ml (5 mcg).

Baeta shiryashi ya hada da:

Latsa kuma raba labarin tare da abokanka:

wani alkalami mai narkewa tare da mafita don gudanar da subcutaneous,
umarnin don amfani da lafiya,
alkalami na sihiri
fakitin kwali.

Bayanai Bayeta

An nuna Bayeta don amfani a waɗannan yanayi:

Nau'in 2 na ciwon sukari mellitus a matsayin monotherapy ban da aikin jiki da abinci don samun isasshen kulawar glycemic,
Nau'in 2 na ciwon sukari mellitus azaman ƙarin jiyya ga ƙwaƙwalwar sulfonylurea, metformin, thiazolidinedione, haɗuwa da kayan haɗin metformin da sulfonylurea, ko metformin da thiazolidinedione ba tare da isasshen kulawar glycemic ba.

Sakamakon sakamako na Baeta

Daga aikace-aikacen Baeta iya Ana kiyaye tasirin sakamako masu zuwa:

Daga tsarin narkewa:

tashin zuciya
amai
zawo
rage cin abinci
kamar haka, gastroesophageal reflux,
dyspepsia
bloating
ciwon ciki
maƙarƙashiya
binnewa
rashin tsoro
take hakkin dandano.

Daga tsarin juyayi na tsakiya:

tsananin farin ciki
ciwon kai
nutsuwa

Daga tsarin endocrine:

ji da rawar jiki
hawan jini,
hyperhidrosis
rauni.

angioedema,
kurji
itching
anaphylactic dauki.

Sauran sakamako masu illa:

itching, redness, kurji a wurin allura,
bushewa.

Yawan overdose Byetoy

Idan akasarin yawan zafin jiki na Bayeta (kashi 10 sau gwargwadon shawarar da aka bayar), ana ganin alamu masu zuwa:

amai
tsananin tashin zuciya
saurin haɓakar hauhawar jini.

Jiyya tare da yawan wuce haddi na Bayeta ya hada da maganin kwantar da hankali, wanda ya hada da gudanar da aikin glucose tare da matsanancin rashin karfin jini.

Umarnin don amfani da byeta

Karatun waɗannan umarnin don amfani da byet baya sauƙaƙa haƙuri daga binciken "Umarnin don yin amfani da magani "located a cikin kwali kwali tare da sirinji alkalami Baeta. Waɗannan umarnin suna amfani da maganin mafita don ƙananan nauyin 250 μg / ml, a cikin kabad na 1, 2 ml a cikin maɓallin sirinji (5 μg).

Don samun sakamako mafi girma daga yin amfani da Bayeta, ya kamata a yi amfani da alkairin sirinji daidai. Rashin bin umarnin don yin amfani da alkalami na Bayeta na iya haifar da ƙaddamar da kashi ba daidai ba, rushewar alkairin sirinji, da kamuwa da cuta. Waɗannan umarnin don amfani basu maye gurbin yin shawarwari tare da likitanka game da yanayin kiwon lafiya ko magani ba. Idan akwai wahala a cikin amfani da alkairin sirinji na Bayeta, ya kamata ka nemi likita. Alƙalin sirinji ya ƙunshi isasshen magunguna don amfani cikin kwanaki 30. Alƙalin sirinji yana yin sakin jiki na samfurin.

Ba a yarda da canja wurin miyagun ƙwayoyi daga ƙwayar sirinji zuwa sirinji ba.

Idan kowane bangare na alkairin ya karye ko ya lalace, kar a yi amfani da alkalami.

Ba'a ba da shawarar yin amfani da maɓallin sirinji don mutanen da ke da cikakkiyar hangen nesa ko tare da hangen nesa mai rauni ba tare da taimakon mutane masu gani sosai ba. A wannan halin, ana buƙatar taimakon mutumin da aka horar da shi ta amfani da alƙalami mai siket.

Dole ne likitoci ko ma'aikatan lafiya su bi ka'idodin ka'idodi don magance allura.

Lokacin amfani da alƙawarin alkalami na Bayeta, dole ne ka bi umarnin don yin alluran tsaftacewar da likitanka suka ba ka.

Dangane da umarnin, ana amfani da maganin Bayeta azaman allura a cikin ƙashin kitse a ciki, cinya ko hannu.

Lokacin fara amfani da shi, an wajabta maganin don amfani da 5 mcg sau biyu a rana (da safe da maraice) na sa'a ɗaya ko a cikin awa daya kafin cin abinci. Idan har batun keta dokar Bayeta, sigar ba ta canzawa. Kwanaki 30 bayan fara shan allurar yana ƙaruwa zuwa 10 mcg (sau biyu a rana).

Bai kamata a gudanar da maganin ba bayan cin abinci. Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin jijiya ko cikin intramuscularly. Idan an gano barbashi na inasashen waje a cikin mafita, ko kuma idan mafita kanta tana da gajimare ko kuma tana da launi, bai kamata a yi amfani da shirye-shiryen Bayeta ba.

A cikin umarnin don amfani, ya kamata ka bar rakodin gaskiya da kwanan wata na farko Yi amfani da alkalami na syringe.

Yin amfani da alkairin sirinji na Bayeta ana aiwatar da shi ne tsakanin kwanaki 30 bayan amfani na farko, muddin ana aiwatar da aikin shirya sabon alkairin sirinji. Kwanaki 30 bayan amfani na farko, ya kamata a zubar da allurar sigar Baeta, koda kuwa fanko ce gabaɗayan.

Ba za a yi amfani da allon sikanin Baeta ba bayan ranar karewa ya nuna akan kunshin mai ƙira.

Idan ya cancanta, shafa alkalami mai rauni daga waje tare da zane mai tsabta, mai laushi.

Lokacin amfani da alkairin sirinji, farin barbashi na iya bayyana a saman katun, wanda ya kamata
cire tare da zane ko auduga swab moistened da barasa.

Tare da haɗuwa da Bayet tare da metformin, thiazolidinedione, ko tare da haɗin waɗannan magungunan, kashi na farko na metformin da / ko thiazolidinedione ba za a iya canza su ba.

Haɗin Baeta tare da abubuwan da ke haifar da maganin sulfonylurea na iya buƙatar raguwa a cikin adadin abubuwan da ake haifar da maganin na sulfonylurea domin rage haɗarin cutar hypoglycemia.

Kafin fara magani tare da Baeta, mai haƙuri ya kamata ya karanta umarnin da aka haɗa "Jagora don amfanin alkairin sirinji".

Baeta na bukatar taka tsantsan a cikin marassa lafiya da ke shan magunguna na baki wanda ke buƙatar ɗaukar hanzari daga hanji - Baeta na iya yin jinkirin narkewa na ciki. Ya kamata a shawarci marassa lafiya da su sha magungunan da ake magana da baki, sakamakon hakan ya dogara ne da maida hankali kan bakin kofofinsu (kwayar rigakafi), akalla sa'a daya kafin aiwatar da ayyukan Bayet Idan ana shan irin waɗannan magunguna tare da abinci, ya kamata a sha yayin waɗancan abincin lokacin ba a amfani Baeta.

Lokacin da yake tsara maganin Baeta a hade tare da digoxin (a kashi na 0.25 MG sau ɗaya a rana), Cmax na digoxin yana raguwa da 17%, Tmax yana ƙaruwa da sa'o'i biyu da rabi. A wannan yanayin, tasirin magunguna gaba ɗaya a ma'aunin canji ba ya canzawa. A game da tushen gabatar da maganin Bayet, Cmax na lovastatin da AUC sun ragu da kashi 28 da 40%, bi da bi. Tmax ya ƙaru da kimanin awa huɗu. Haɗin haɗin inginar HMG-CoA reductase inhibitor tare da Bayeta baya haɗuwa tare da canji a cikin abubuwan haɗin jini (triglycerides, low-yawa cholesterol-lipoproteins, high-yawa cholesterol-lipoproteins, da kuma jimlar cholesterol).

A cikin marasa lafiya masu fama da hauhawar jini na matsakaici ko matsakaici, wanda ke kwance ta hanyar lisinopril (5-20 mg a kowace rana), Bayeta bai canza yanayin Cmax na lisinopril da AUC a ma'auni ba. Tmax na lisinopril a ma'auni ya karu da awa 2. Ba a lura da canje-canje a cikin yau da kullun ma'anar diastolic systolic pressure jini ba.

Tare da gabatarwar warfarin mintuna talatin bayan shan Bayeta, Tmax yana ƙaruwa da 2 hours. Babu wani canji mai mahimmanci a Cmax da AUC da aka lura. Ba a yi nazarin yin amfani da Baeta ba tare da insulin, meglitinides, abubuwan da ake samu na D-phenylalanine, ko alpha-glucosidase inhibitors.

Samun kyakkyawan sakamako daga amfani da maganin Bayeta baya warwarewa da bukatar tsarin kulawa da lafiyar mai lafiya ta kwararrun kwararru, likitocin cibiyoyin lafiya, asibitoci, dakunan shan magani, dakunan gwaje-gwaje, da sauran cibiyoyi na musamman. Binciken lokaci, aiwatar da matakan kariya zai inganta tasirin maganin.

Duba Syringe Pen Check

Kafin ka fara amfani da alkairin sirinji na Bayeta, ka wanke hannuwanka. Wajibi ne a duba lakabin a alƙalin sirinji don tabbatar da cewa wannan alkalami na 5 microgram ne. Cire shugabar shudi shuki na alkairin.

Ya kamata ku duba magungunan Bayeta a cikin kicin. Maganin zai zama m, mara launi, bai ƙunshi barbashi na kasashen waje ba. Idan ba za a bi ka ba, kada a yi amfani da alkalami na ƙararrawa.

Haɗu da allura zuwa maɓallin sirinji

Wajibi ne don cire sandar takarda daga ƙasan allurar ta, sanya allura tare da mabuɗin kai tsaye akan axis akan alƙalin syringe, sannan a harba allura har sai an daidaita. Bincika don ɗauri.

Wajibi ne don cire maɗaurin murfin na ciki. Kada a jefa ƙwanƙwasa - za'a buƙaci saka shi a kan kaifin allura kafin zubar dashi. Kar a zubar da allura ba tare da matsanancin hula ba.

Cire kwalban allura na ciki ka zubar dashi. A wasu halaye, karamin digo na maganin shirin Baeta yana bayyana a ƙarshen allura, wannan al'ada ce.

Yin Baeta

Tabbatar cewa an nuna alamar "hannun dama" a cikin taga kashi. In bahaka ba, juya saiti na ringin agogon hannun agogo har sai ya tsaya, har sai alamar “hannun dama” ta bayyana a cikin taga kashi

Wajibi ne a ja zoben saitin sirinji na sirinji har sai ya tsaya, har sai alamar kibiya sama ta bayyana a taga. Yakamata ya sake jujjuya hula ta hanyar motsi ba tare da wani ƙoƙari ba.

Juya ringi saita saitin juzu'i a allon agogo har sai alamar “5” ta bayyana. Kuna buƙatar tabbatar cewa lambar "5" tare da layin da ke ƙasa yana cikin ɓangaren tsakiyar taga kashi.

Syringe alkalami shiri

Wajibi ne a sanya alkalami a cikin hanyar da allura ke nunawa kuma ya shuɗe daga gare ku. Ya kamata a aiwatar da shirye-shiryen alkairin sirinji na Bayeta cikin isasshen haske.

Yakamata kayi amfani da babban yatsa don danna maɓallin don tabbatar da amfani da ƙimar Bayeta zuwa tasha, bayan hakan, yayin da kake ci gaba da riƙe maɓallin don sarrafa maganin, a hankali ƙidaya zuwa biyar.

Ana shirya shirye-shiryen alkairin sirinji idan alamar “alwatika” ta bayyana a tsakiyar ɓangaren kashi na taga, ƙyalli ko dropsan saukad da maganin Bayeta ya bayyana a saman allura.

Cikakken Tsarin Syringe Pen

Juya yanayin sautin ringin ta agogon hannu har sai ya tsaya har sai alamar "kibiya dama" ta bayyana a cikin taga kashi.

Ana kammala shirin sabon alkairin sirinji. Karku maimaita matakai don shirya sabon alƙalin sirinji don amfanin yau da kullun. Idan an yi hakan, shirye-shiryen Bayeta zai ƙare kafin karewar kwanaki 30 na amfani.

Yin Baeta

Riƙe alkalami na Bayet da ƙarfi, saka allura a fata. Lokacin gudanar da maganin, yi amfani da tsarin tsabta mai tsabta ta likitan halartar.

Yin amfani da babban yatsa, danna maɓallin sakin kashi da tsayawa, to, yayin da kuke ci gaba da riƙe maɓallin sakin, a hankali ƙidaya zuwa 5 saboda ana amfani da maganin.

An yi la'akari da allurar cikakke lokacin da alamar "alwatika" ta bayyana a tsakiyar ɓangaren kashi na kashi. An shirya alkalami na atomatik don gabatar da sabon kashi.

Idan bayan allurar kaxan kadan na magungunan Bayeta sun fita daga allura, wannan yana nuna cewa ba a matsi maɓallin kashi ba.

Cirewa da kuma zubar da Abubuwan Cire Magunguna na Syringe

A hankali cire haɗin allura bayan kowane allura tare da sirinji na Baeta. Bayan cire haɗin allura, a hankali saka ƙyalƙyar allura ta a saman allura.

Bayan kwance allurar, sanya maɗaurin shudin shuɗin a kan alƙalin sirinji na Bayeta kafin a ajiye. Ajiyewar alkalami na syringe ba tare da hula ba an yarda dashi.

Dole a jefa allurar da aka yi amfani da ita a cikin akwati mai tsaurin rigakafin huda. Wajibi ne a bi sauran shawarwarin likitan da ke halartar.

Tambayoyi game da amfani da Bayeta Syringe Pen

Sai na shirya sabonn alkairin sirinji na Bayeta don amfani kafin kowanne kashi?

A'a. Ana aiwatar da sabon firinji don yin amfani da shi don yin amfani da su sau ɗaya kafin amfani dashi. Dalilin shirye-shiryen shi ne tabbatar da cewa alkalami mai sirinji na Bayeta ya shirya don amfani tsakanin kwanaki 30 masu zuwa. Lokacin sake sabon firinji na sirinji, kowane kashi na al'ada na Bayeta bai isa kwana 30 ba. Smallan ƙaramin shiri na Bayeta da aka cinye wajen shirya sabon sirinji don amfani ba zai yi tasiri cikin tanadin kwanaki 30 na shirin Bayeta ba.

Me yasa akwai kumfa a cikin kicin ɗin Byet?

Kasancewar karamin kumfa a cikin kicin, yanayin al'ada ne wanda bai shafi sashi ba. Idan an ajiye alkairin sirinji tare da allura da aka haɗe da shi, kumburin iska na iya samarwa a cikin kicin. Karku ajiye allurar sirinji tare da allura da aka haɗe da ita.

Me zan yi idan maganin Bayeta bai bayyana a ƙarshen allura ba bayan ƙoƙari huɗu don shirya sabon sirinji don amfani?

A wannan halin, cire haɗin allura ta hanyar sa murfin allura a hankali, kwance allurar kuma zubar dashi. Haɗa sabon allura kuma maimaita matakai don shirya sabon alkairin sirinji don amfani. Lokacin da dropsan saukad ko guntun maganin maganin ya bayyana a ƙarshen allurar, shirye-shiryen alkalami ya cika.

Me yasa maganin Bayeta zai fita daga allura bayan allurar ta gama?

Ana la'akari da al'ada idan, bayan an gama allura, digo na maganin maganin ya zauna a ƙarshen allura.

Idan an lura fiye da digo ɗaya a ƙarshen allura:

Kada a karɓi sashi da cikakke. Kada ayi amfani da magani kafin a shawarci masu kula da lafiyar ku,
Don guje wa maimaita halin da ake ciki, don ingantaccen tsarin kulawa na gaba, latsa ka riƙe maɓallin kashi a cikin wurin da aka rage sannan a hankali ƙidaya zuwa biyar.

Ta yaya zan iya gano lokacin da allurar ta Baetoy ta cika?

An yi amfani da allura cikakke idan:

An latsa maɓallin kashi kuma an riƙe shi da ƙarfi a cikin recessed matsayi har sai ya tsaya,
Yayin riƙe maɓallin a cikin wurin da aka sake, mai haƙuri a hankali ya ƙidaya zuwa biyar, allura a lokacin yana cikin fata,
Alamar "alwatika" ta kasance a tsakiyar taga kashi yayin aiwatar.

A ina zan shigar da Bayeta?

Byeta an allura cikin ciki, cinya ko kafada ta amfani da dabarar allurar da likitanka ya ba da shawarar ka.

Me yakamata in yi idan ba zan iya ja, juya, ko danna kan ƙarar ringing na alƙalin rubutun bayet ba?

Duba alamar a cikin taga kashi. Bi umarnin kusa da alamar alama.

Idan an nuna alamar “hannun dama” a cikin taga kashi:

Ja da saitin yanayin har zuwa lokacin kibiya sama ta bayyana.

Idan aka nuna alamar kibiya sama a taga kuma matakin zobe to bai cika juyawa ba:

Wataƙila babu isasshen magani da ya rage a cikin akwatin alkalami na Bayet don cike cikakken kashi. Smallarin ƙaramar Bayeta koyaushe ana barin shi a cikin kayan. Idan an bar ɗan adadin maganin a cikin kicin ko kuma ga alama babu komai, a wannan yanayin akwai buƙatar samun sabon alkairin sirinji na Bayet.

Idan alamar “sama kibiya” da kuma alamar alama “5” an nuna su a taga kashi, kuma ba a danna zobe na kashi ba:

Ba a juya yatsar gwargwadon matakin da ya dace. Ci gaba da kunna saiti na agogo ta agogon hannu har sai alamar “5” ta bayyana a tsakiyar taga matakin.

Idan alamar “5” kuma ta wani bangare alamar “alwatika” ana nunawa a ɓangaren window ɗin, kuma ba a matse zoben saitin sashi ba:

Wataƙila a rufe, toshe, ko a haɗe da kyau,

Haɗa sabon allura. Tabbatar cewa allura tana zaune kai tsaye a kan bututun kuma an goge ta har ya zuwa,
Latsa maɓallin sashi na tsaye da tabbaci har sai ya daina. Bayeta ya kamata ya bayyana a ƙarshen ƙarshen allura.

Idan an nuna alamar alwatika a cikin taga kashi kuma ringin saita sashi ba ya juyawa:

Ba a matsi maɓallin Byeta cikakke ba kuma ba a gudanar da cikakken maganin ba. Yakamata ka nemi likitanka me za'ayi idan aka gabatar da wani matakin da bai cika ba.

Dole ne a bi umarnin mai zuwa don sake shigar da alkalami na Bayet don allurar ta gaba:

Latsa maɓallin sashi na tsaye da tabbaci har sai ya daina. Ci gaba da riƙe maɓallin kashi a cikin wurin da aka sake, a hankali ƙidaya zuwa biyar. Sannan juya jujjuyawar yanayin ringin agogon hannun agogo har sai alamar “hannun dama” ta bayyana a cikin taga kashi.
Idan har yanzu baza ku iya sa ringin saitin kashi ba, to allurar na iya toshewa. Sauya allura kuma maimaita aikin da aka bayyana a sama.

Don gudanar da maganin na Beta na gaba, danna kuma riƙe maɓallin kashi a cikin wurin da aka rage sannan a hankali ƙidaya zuwa biyar kafin cire allura.

Tambayoyi game da Aljihu na Syringe Pen Baeta

Wani irin allura zan iya amfani da shi da alƙalin sirinji na Baeta?

Ba a haɗa allurai cikin alkalami na alkairin Bayet ba. Don sayan allura a cikin kantin magani, kuna buƙatar takardar sayan magani. Lokacin amfani da alƙawarin Bayet, za a iya amfani da allura da za'a iya amfani da su don alkairin alkalami 12, 7 mm, 8 mm ko 5 mm tsayi (diamita 0, 25-0, 33 mm) ya kamata ayi amfani da shi. Ya kamata a duba tsayi da diamita da suka dace don amfani da likitan ku.

Shin ina buƙatar yin amfani da sabon allurar allurar allurar Bayeta?

Dole ne ayi amfani da sabon allura don kowane allura. Maimaita yin amfani da allura bai halatta ba. Bayan allura, sai a yanke allura, wannan yana taimaka wajan hana yaduwar maganin alkairin Bayet, kasancewar kumfa, rage yiwuwar toshe allura, da rage hadarin kamuwa da cuta.

Kar a danna maɓallin kashi idan ba a haɗa allura da alkalami na alkairin ba.

Ta yaya zan zubar da allura bayan da amfani da Byet?

Ya kamata a jefa allura da aka yi amfani da su cikin akwati mai iya huɗama, ko bi shawarar likitanka. Kada a jefa alkairin sirinji tare da allura da aka haɗe da shi. Kada a canja wurin sirinji na alkalami ko allurai na Baeta ga wasu.

Adana Baeta

Ana adana baƙin sirinji na Bayeta wanda ba a amfani dashi a cikin kwalin kwali na asali a cikin firiji a zazzabi na 2-8 ° C, a cikin duhu. Lokacin adana alkairin sirinjin Bayeta, bai kamata ya daskare ba. Idan shirye-shiryen da aka daskarewa yayin ajiya, ƙarin amfanirsa yana halatta.

Lokacin amfani, dole ne a adana alkairin sirinji na Bayeta a zazzabi da bai wuce 25 ° C ba sama da kwanaki 30.

Karku ajiye sirinji na Byeta tare da allura a haɗe. Idan aka bar allura, maganin da Bayeta zai iya fitarwa zai iya fitowa daga alkairin sirinji, kumburin iska na iya fitowa a cikin kicin.

Storage na Byet ne m yara.

Tsayayyar rayuwar Baeta ita ce watanni 24 daga ranar da aka saki maganin.

Baeta da Victoza

Baeta da shirye-shiryen Viktoza sune abubuwan maye gurbi, ana samarwa a cikin alkalami na sikastin na karkashin kasa, kuma ana amfani dasu wajen maganin nau'in ciwon sukari na 2 na mellitus. Tsarin amfani da waɗannan magunguna yana taimakawa rage ƙwayar haemoglobin ta glycated da 1-1, 8% kuma rasa nauyi da kilo huɗu zuwa biyar don watanni 10-12 na amfani. Duk da yawan sigogi na gaba daya, da kuma tsarin aikin Viktoza da Byet, nadin wani takamammen magani ya kasance cikin kwarewar likita.

Baeta Farashi (Exenatide)

Farashin Exenatide Baeta Syringe Pens ba ya haɗa da farashin jigilar kaya idan an sayo maganin ta hanyar kantin magani ta kan layi. Farashi na iya bambanta sosai dangane da wurin siye da siye.

Rasha (Moscow, St. Petersburg) daga 3470 zuwa 6950 rubles,
Ukraine (Kiev, Kharkov) daga 1145 zuwa 2294 hryvnias na Ukraine,
Kazakhstan (Almaty, Temirtau) daga 16344 zuwa 32735 Kazakhstan tenge,
Belarus (Minsk, Gomel) daga 912610 zuwa 1827850 Belarusian rubles,
Kasar Moldova (Chisinau) daga 972 zuwa 1946 Moldovan Lei,
Kyrgyzstan (Bishkek, Osh) daga 3,782 zuwa 7,576 Kyrgyz som,
Uzbekistan (Tashkent, Samarkand) daga 134567 zuwa 269521 wakilin sojan Uzbek,
Azerbaijan (Baku, Ganja) daga 51.7 zuwa 103.6 Azerbaijani manats,
Armenia (Yerevan, Gyumri) daga 23839 zuwa 47747 drams na Armenia,
Georgia (Tbilisi, Batumi) daga 118.0 zuwa 236.3 Georgian lari,
Tajikistan (Dushanbe, Khujand) daga 326.9 zuwa 654.7 Tajik somoni,
Turkmenistan (Ashgabat, Turkmenabat) daga 167.6 zuwa 335.7 sabon tsarin Turkmen.

Sayi Baeta

Saya Kuna iya amfani da maganin a cikin alkalannin sirinji na Bayeta a kantin magani ta amfani da sabis na ajiyar magani, gami da tarawa. Kafin ka sayi Bayeta, ya kamata ka fayyace ranar karewar miyagun ƙwayoyi. Kuna iya ba da umarnin Byet a kowane kantin magani na kan layi, ana siyar da kaya tare da bayarwa, yayin gabatar da takardar sayen magani na likita.

Yin Amfani da Baeta

Bayanin maganin shaye shaye na ƙwayar cutar Bayeta (Exenatide) akan ƙararrakin likita My Kwayoyi cikakkun bayanai ne "Umarnin don yin amfani da magani na Byet". Kafin siyan da fara amfani da maganin, ya kamata ku fahimci kanku da umarnin da mai sana'anta ya yarda da shi, yi shawara tare da ƙwararren likitan likitanci, likita. Bayanin magungunan Bayeta (Exenatide) an bayar dashi don dalilai na bayanai kuma ba jagora bane don amfani da magani na kai.