Lantus SoloStar
Magunguna Lantus SoloStar (Lantus solostar) an samo asali ne daga yanayin kwantar da hankalin ɗan adam, wanda yake da ƙarancin ƙarfi a cikin yanayin tsaka tsaki. Saboda yanayin acidic na mafita Lantus SoloStar insulin glargine an narkar da shi gabaɗaya, amma tare da gudanar da subcutaneous, acid din ya lalace kuma an kirkiro microprecipitates saboda raguwar narkewar ƙwayar cuta, daga ciki a hankali yake fitowa. Don haka, hauhawar hankali a cikin ƙwayar plasma na insulin ba tare da kololuwar kaɗa ba kuma ana samun sakamako mai tsawo na magungunan Lantus SoloStar.
A cikin insulin glargine da insulin na mutum, hanyoyin sadarwa tare da masu karɓar insulin suna kama da haka. Bayanan martaba da ƙarfin insulin glargine suna kama da na insulin ɗan adam.
Magungunan yana daidaita metabolism, musamman, yana rage yawan ƙwayar glucose plasma ta hanyar rage samarwarsa a cikin hanta da kuma ƙara yawan amfani da glucose ta ƙwararrun yanki (galibi tsoka da tsopose nama). Insulin yana hana proteinolysis da lipolysis a cikin adipocytes, kuma yana inganta haɓakar furotin.
Ayyukan insulin glargine, ana sarrafawa a ƙarƙashin ƙasa, yana haɓaka sannu a hankali fiye da gabatarwar NPH na insulin, kuma ana nuna shi ta hanyar mafi tsayi da rashin ƙimar mafi girman daraja. Ta wannan hanyar magani Lantus SoloStar za a iya amfani da 1 sau ɗaya kowace rana. Lura cewa tasiri da tsawon lokacin insulin na iya bambanta sosai koda cikin mutum ɗaya (tare da ƙara yawan motsa jiki, karuwa ko rage damuwa, da sauransu).
A cikin binciken asibiti na bude, an tabbatar da cewa insulin glargine baya haɓakar ciwan mai ciwon sukari (alamomin asibiti don amfanin insulin glargine da insulin ɗan adam bai bambanta ba).
Lokacin amfani da miyagun ƙwayoyi Lantus SoloStar An daidaita yawan insulin na insulin a ranar 2-4.
Insulin glargine yana cikin metabolized a cikin jiki don samar da metabolites guda biyu masu aiki, M1 da M2. Mahimmanci a cikin tasirin sakamako na miyagun ƙwayoyi Lantus SoloStar an buga shi ta hanyar metabolite M1, a cikin jini an ƙaddara glargine insulin da aka canza da M2 metabolite a cikin adadi kaɗan.
Babu wani bambance-bambance masu mahimmanci a cikin inganci da amincin insulin glargine a cikin marasa lafiya na ƙungiyoyi daban-daban kuma a cikin yawan haƙuri.
Alamu don amfani:
Lantus SoloStar An yi amfani da shi don kula da marasa lafiya a cikin shekaru 6 da ciwon sukari-dogara da ciwon sukari mellitus.
Hanyar amfani:
Lantus SoloStar aka yi niyya don gudanar da subcutaneous. An bada shawara don gabatar da miyagun ƙwayoyi Lantus SoloStar a lokaci guda na rana. Matsakaitan magungunan Lantus SoloStar an zaɓi ɗaya daban ta likita. Ya kamata a ɗauka cewa ana nuna ƙwayar magunguna a cikin matakan rayayyun abubuwan da suka sha bamban kuma ba za a iya kwatanta su da ɓangarorin aikin sauran insulins ba.
An yarda da amfani da miyagun ƙwayoyi Lantus SoloStar a cikin marasa lafiya da nau'in ciwon sukari na 2 na mellitus a hade tare da wakilai na bakin jini na hypoglycemic.
Sauyawa daga sauran insulin zuwa Lantus SoloStar:
Lokacin canzawa zuwa Lantus SoloStar daga wasu matsakaici na matsakaici ko aiki na tsayi, ana iya buƙatar gyaran kashi na yau da kullun na insulin basal, kazalika da canji a allurai da jadawalin shan sauran wakilai na hypoglycemic. Don rage haɗarin rashin lafiyar ƙwaƙwalwar maraice a yayin juyawa zuwa Lantus SoloStar a cikin 'yan makonnin farko, ana ba da shawarar rage ƙananan bashin na insulin da kuma gyaran insulin da ya dace, wanda aka gabatar dangane da cin abinci. Bayan 'yan makonni bayan farawar Lantus SoloStar miyagun ƙwayoyi, ana yin gyare-gyaren kashi na insulin na basal da insulins na ɗan gajeren lokaci.
A cikin marasa lafiya da ke karɓar insulin na dogon lokaci, bayyanar ƙwayoyin rigakafi ga insulin da raguwa da amsawa ga gudanarwar miyagun ƙwayoyi Lantus SoloStar mai yiwuwa ne.
Lokacin yin sauyawa daga insulin zuwa wani, kazalika a lokacin daidaita ƙimar kashi, ya kamata a kula da matakan glucose na plasma musamman a hankali.
Gabatar da magunguna Lantus SoloStar:
Ana gudanar da maganin a cikin subcutaneously a cikin deltoid, cinya ko yanki na ciki. An bada shawara don canza wurin allurar a cikin wuraren da aka yarda da su a kowane allurar miyagun ƙwayoyi Lantus SoloStar. An hana shi gudanar da Lantus SoloStar cikin jijiya (saboda haɗarin yawan haɗuwa da yawan ciwan jini da haɓaka mai ƙarfi).
Haramun ne a haxa maganin insulin glargine da sauran magunguna.
Nan da nan kafin aikin insulin glargine, cire kumfa daga cikin akwati kuma kuyi gwajin lafiya. Kowane allura yakamata a gudanar dashi tare da sabon allura, wanda aka sa a kan alƙalin syringe nan da nan kafin amfani da miyagun ƙwayoyi.
Yin amfani da Syringe Pen Lantus SoloStar:
Kafin amfani, yakamata ku bincika katun katako na sirinji, zaku iya amfani da ingantaccen bayani ba tare da laka ba. A cikin abin da ya faru da hazo ya bayyana, girgije, ko canza launi na mafita, an hana yin amfani da miyagun ƙwayoyi. Yakamata a watsar da almurar sirinji. Idan alkairin sirinji ya lalace, ya kamata ka ɗauki sabon alƙalin sifar ka zubar da wanda ya lalace.
Kafin kowane allura, yakamata a yi gwajin lafiya:
1. Binciko alamar insulin da bayyanar mafita.
2. Cire kwallar alkairin sirinji ka haɗa sabon allura (ya kamata a buga allurar nan da nan kafin a ɗauka, an haramta haɗa allura a kusurwa).
3. Auna kashi na kashi 2 (idan har ba a yi amfani da alkairin syringe 8 ba) sanya allurar sirinji tare da allura sama, a hankali a mato kayan, danna maɓallin shigarwa gabaɗaya kuma ka duba fitowar insulin a saman allurar.
4. Idan ya cancanta, ana gudanar da gwajin lafiya sau da yawa har sai bayani ya bayyana a saman allura. Idan bayan gwaje-gwaje da yawa insulin bai bayyana ba, maye gurbin allura. Idan waɗannan matakan ba su taimaka ba, alkalami mai rauni yana da lahani, kar a yi amfani da shi.
An hana shi canja wurin abin da yake sanya maye ga wasu mutane.
An bada shawara koyaushe don samun takamaiman sirinji alkalami Lantus SoloStar Idan har aka lalace ko asarar da alkalami da aka yi amfani da shi.
Idan an adana alkalami a cikin firiji, ya kamata a cire shi 1-2 sa'o'i kafin allurar ta yadda mafita za ta yi zafi har zuwa ɗakin zazzabi.
Ya kamata a kiyaye alkairin sirinji daga datti da ƙura, zaku iya tsabtace waje na alkairin sirinji tare da zane mai bushewa.
Haramun ne a wanke alkalami Lantus SoloStar.
Kashi zaɓi:
Lantus SoloStar ba ku damar saita sashin daga 1 naúrar zuwa raka'a 80 a cikin ƙarfe na 1 naúrar. Idan ya cancanta, shigar da kashi fiye da 80 raka'a don aiwatar da injections da yawa.
Tabbatar cewa bayan gwajin aminci, taga allurai yana nuna “0”, zaɓi sigar da ake buƙata ta juyawa mai zaɓar dosing. Bayan zabar madaidaicin kashi, shigar da allura a cikin fata kuma latsa maɓallin shigarwa duk tsawon lokacin. Bayan an gudanar da maganin, darajar "0" ya kamata a saita a cikin taga allurai. Barin allurar a cikin fata, kirga zuwa 10 sannan cire cire allura daga fata.
Cire allura daga maɓallin sirinji ka zubar da shi, ka rufe alkairin sirinji tare da hula kuma adanawa har sai allura ta gaba.
Sakamako masu illa:
Lokacin amfani da miyagun ƙwayoyi Lantus SoloStar a cikin marasa lafiya, ci gaban hypoglycemia mai yiwuwa ne, saboda duka gabatarwar babban kashi na insulin da canjin abinci, aikin jiki da haɓaka / kawar da yanayi mai damuwa. Poarfin hypoglycemia mai zurfi na iya haifar da ci gaba da rikicewar cututtukan zuciya kuma yana haifar da barazana ga rayuwar mai haƙuri.
Bugu da kari, lokacin amfani da miyagun ƙwayoyi Lantus SoloStar yayin gwaji na asibiti a cikin marasa lafiya, an lura da sakamako masu illa:
Daga tsarin juyayi da gabobin azanci: dysgeusia, retinopathy, rage ƙarancin gani na gani. Poarfin hypoglycemia mai zurfi na iya haifar da ci gaba da asarar hangen nesa na ɗan lokaci a cikin marasa lafiya tare da farfadowa na farfadowa.
A ɓangaren fata da ƙananan ƙwayar fata: lipodystrophy, lipoatrophy, lipohypertrophy.
Allergic halayen: na kowa fata rashin lafiyan halayen, bronchospasm, anaphylactic rawar jiki, Quincke ta edema.
Sakamakon cikin gida: hyperemia, edema, tashin hankali da halayen kumburi a wurin allurar Lantus SoloStar.
Sauran: zafin tsoka, riƙewar sodium a cikin jiki.
Bayanin kare lafiya Lantus SoloStar a cikin yara sama da 6 shekaru da manya ma haka lamarin yake.
Yarjejeniyar:
Lantus SoloStar kar a baka wa marasa lafiya da sanannen halin rashin lafiyar insulin glargine ko kuma wasu abubuwanda suka hada maganin.
Ba a amfani da Lantus SoloStar don bi da marasa lafiya da ke fama da rauni na nakasa da aikin hepatic.
A cikin ilimin yara, da miyagun ƙwayoyi Lantus SoloStar amfani kawai don lura da yara kanana shekaru 6.
Lantus SoloStar ba magani na zabi don lura da cutar ketoacidosis mai ciwon sukari ba.
A cikin tsofaffi marasa lafiya, kazalika da marasa lafiya da ke fama da rauni na aiki da kuma aikin hepatic, bukatun insulin na iya raguwa, irin waɗannan marasa lafiya ya kamata a tsara Lantus SoloStar tare da taka tsantsan (tare da sanya idanu akai-akai game da matakan glucose).
Yakamata a yi taka tsantsan lokacin zaɓin allurai ga marasa lafiya waɗanda a cikin su ƙwararrakin jini na iya samun babban sakamako.
Musamman, tare da taka tsantsan, an wajabta Lantus SoloStar ga marasa lafiya da ke fama da cutar sankara ko kuma jijiyoyin bugun jini da kuma farfadowa na ƙwayar cuta.
Yakamata a yi taka-tsantsan yayin rubuta Lantus SoloStar ga marasa lafiya waɗanda yanayin alamun hypoglycemia suna blurry ko mai sauƙi, haɗe da marasa lafiya tare da haɓaka cikin glycemic indices, dogon tarihin ciwon sukari, ciwon kai, cututtukan kwakwalwa, haɓakar hankali na hankali, da tsofaffi marasa lafiya da marasa lafiya, cewa tafi daga insulin dabbobi zuwa mutum.
Hakanan yakamata a yi amfani da shi lokacin da ake rubuta magani. Lantus SoloStar marasa lafiya suna da haɓakar haɓakar haɓakar jini. Hadarin cutar hawan jini yana ƙaruwa tare da canji a wurin kula da insulin, karuwar haɓakar insulin (ciki har da kawar da yanayin damuwa), ƙara yawan aiki ta jiki, abinci mara kyau, amai, gudawa, shan barasa, cututtukan da ba a daidaita su ba na tsarin endocrine, da kuma amfani da wasu magunguna ( duba ma'amala da wasu magunguna).
Marasa lafiya tare da masu ciwon sukari ya kamata su yi hankali don sarrafa hanyoyin da ba za a iya amfani da su ba, ci gaban hypoglycemia zai iya haifar da jin kai da raguwa a cikin taro.
Ciki
Babu bayanan asibiti game da amfani da miyagun ƙwayoyi Lantus SoloStar a cikin mata masu juna biyu. A cikin nazarin dabbobi, bayyanar rashin lafiyar teratogenic, mutagenic da amfrayo na kwayar insulin glargine, da kuma mummunan tasirinsa game da ciki da haihuwa. Idan ya cancanta, za a iya wajabta Lantus SoloStar ga mata masu juna biyu. Ya kamata a kula da matakan glucose na plasma a cikin mata masu juna biyu, idan aka ba da canje-canje ga bukatun insulin. A cikin farkon farkon, buƙatar insulin na iya raguwa, kuma a na biyu da na uku yana ƙaruwa.
Nan da nan bayan haihuwa, buƙatar insulin ya ragu kwata-kwata kuma akwai haɗarin hauhawar jini.
A lokacin lactation, da miyagun ƙwayoyi Lantus SoloStar za'a iya amfani dashi tare da ci gaba da lura da matakan glucose na jini. Babu bayanai game da shigarwar insulin glargine zuwa cikin nono, amma a cikin narkewa, insulin glargine ya kasu kashi amino acid kuma ba zai iya cutar da jarirai wadanda uwayensu ke karbar magani tare da Lantus SoloStar ba.
Yin hulɗa tare da wasu kwayoyi:
Tasirin maganin Lantus SoloStar na iya bambanta tare da amfani da wasu magunguna, musamman:
Magungunan antidiedi na baka, angiotensin da ke canza inzyme enzyme, hanawar sinadarin monoidine, salicylates, sulfanilamides, fluoxetine, propoxyphene, pentoxifylline, rashin bin doka da fibrates suna haifar da tasirin insulin glargine lokacin amfani tare.
Corticosteroids, diuretics, danazole, glucagon, diazoxide, estrogens da progestins, isoniazid, sympathomimetics, somatropin, masu hana masu kariya, kwayoyin hormones da antipsychotics suna rage tasirin hypoglycemic na miyagun ƙwayoyi Lantus SoloStar.
Gwargwadon sinadarin Lithium, clonidine, pentamidine, barasa na ethyl da beta-adrenoreceptor na iya ɗayan biyun kuma su rage tasirin hypoglycemic na miyagun ƙwayoyi Lantus SoloStar.
Lantus SoloStar yana rage zafin cutar sakamakon clonidine, reserpine, guanethidine da beta-adrenergic blockers.
Yawan abin sama da ya kamata
Tare da yawan yawan ƙwayar insulin glargine, marasa lafiya suna haɓaka ƙarancin cututtukan cututtuka daban-daban. Tare da mummunan hypoglycemia, ci gaban tashin hankali, coma da cuta na jijiya mai yiwuwa ne.
Sanadin yawan yawan shan magunguna Lantus SoloStar za a iya samun canji a cikin allura (gudanar da babban aiki), tsallake abinci, ƙara yawan motsa jiki, amai da gudawa, cututtukan da ke rage buƙatar insulin (ciki har da naƙasa ta aiki da jijiyoyin jini, hauhawar ƙwayar ciki, huhun ciwan ciki, hanji mai narkewa ko glandar thyroid), canjin wuri gabatarwar miyagun ƙwayoyi Lantus SoloStar.
An daidaita nau'ikan cututtukan hypoglycemia ta hanyar maganin ƙwayar carbohydrates (ya kamata ku ba da carbohydrates ga mai haƙuri na dogon lokaci kuma ku kula da yanayinsa, tun da miyagun ƙwayoyi Lantus SoloStar yana da sakamako mai tsawo).
Tare da mummunan hypoglycemia (tare da tare da bayyanar cututtukan neurological), gudanarwar glucagon (subcutaneously ko intramuscularly) ko gudanarwa na jijiyoyin kwantar da hankula da aka samar da glucose.
Ya kamata a kula da yanayin haƙuri a ƙƙalla na sa'o'i 24, tun da ɓarkewar cututtukan jini na iya sake komawa bayan dakatar da harin hypoglycemia da inganta yanayin haƙuri.
Sakin saki:
Magani don injections Lantus SoloStar 3 ml a cikin katako, an sanya hermetically cikin alƙalin sirinji mai diski, sa alkalami 5 ba tare da allura allura cikin kwali ba.
Yanayin ajiya:
Lantus SoloStar ya kamata a adana shi sama da shekaru 3 bayan ƙirƙirar a cikin ɗakuna inda aka kiyaye tsarin zafin jiki daga digiri 2 zuwa 8 Celsius. Kiyaye alkalami mai rauni daga wurin isar yara. Haramun ne ya daskare maganin Lantus SoloStar.
Bayan amfani na farko, ana iya amfani da maɓallin sirinji don ba zai wuce kwanaki 28 ba. Bayan fara amfani da shi, ya kamata a adana alkalami a cikin ɗakuna tare da yanayin zafin jiki na 15 zuwa 25 digiri Celsius.
Abun ciki:
1 ml bayani don allura Lantus SoloStar ya ƙunshi:
Insulin glargine - 3.6378 mg (daidai yake da raka'a 100 na gulingine insulin),
Ingredientsarin sinadaran.
