Isulin insulin

Sunan kasuwanci na shirye-shiryen: Inginin inulin-in-In-In-ins (Inulin-in-In-In-in-in-in-adam -

Sunan kasa da kasa mai zaman kansa: Insulin + Isofan

Tsari sashi: dakatarwa don gudanarwa karkashin mulki

Aiki mai aiki: insulin + isophane

Rukunin Magunguna: matsakaici insulin

Aikin magunguna:

Matsakaici insulin. Yana rage maida hankali na glucose a cikin jini, yana kara yawanshi ta hanyar kyallen takarda, yana inganta lipogenesis da glycogenogenesis, sunadaran gina jiki, yana rage yawan samarda glucose ta hanta.

Yana hulɗa tare da takamaiman mai karɓa a kan sel na waje kuma yana samar da mahaɗar insulin na insulin. Ta hanyar kunna kwayar cAMP (a cikin ƙwayoyin mai da ƙwayoyin hanta) ko kai tsaye shiga cikin sel (tsokoki), ƙwaƙwalwar mai ɗaukar insulin ɗin tana ta motsa hanyoyin cikin ciki, gami da kira na enzymes masu yawa (hexokinase, pyruvate kinase, glycogen synthetase, da sauransu). Rage glucose a cikin jini yana faruwa ne saboda karuwa a cikin jijiyoyin zuciya, karɓar karɓar ƙwaƙwalwa da inganta kyallen takarda, ƙarfafa lipogenesis, glycogenogenesis, haɗin furotin, raguwa a cikin yawan samar da glucose ta hanta (rage raguwar glycogen), da sauransu.

Bayan allurar sc, tasirin yana faruwa a cikin awanni 1-1.5. Matsakaicin sakamako yana cikin tazara tsakanin sa'o'i 4-12, tsawon lokacin aikin shine awanni 11-24, gwargwadon abun da ya shafi insulin da kashi, yana nuna mahimmancin rikice-rikice na ciki da na ciki.

Alamu don amfani:

Type 1 ciwon sukari.

Nau'in 2 na ciwon sukari mellitus, mataki na tsayayya da maganganun maganganu na baki, juriya ga magungunan baka na baki (hadewar hankali), cututtukan cutuka, hanyoyin tiyata (mono-or treatment therapy), ciwon sukari na mellitus yayin daukar ciki (idan maganin rage karfin abinci).

Yarjejeniyar:

Hypersensitivity, hypoglycemia, insulinoma.

Sashi da gudanarwa:

P / C, sau 1-2 a rana, mintuna 30-45 kafin karin kumallo (canza wurin allura a kowane lokaci). A cikin lokuta na musamman, likita na iya yin allurar a / m na miyagun ƙwayoyi. An hana / shigarwar insulin na matsakaici tsaka! An zabi allurai daban-daban kuma sun dogara da abubuwan da ke cikin glucose a cikin jini da fitsari, halayen hanyar cutar. Yawanci, allurai sune 8-24 IU sau 1 a rana. A cikin manya da yara masu ƙarfin jijiyoyi ga insulin, ƙarancin ƙasa da 8 IU / rana na iya isa, a cikin marasa lafiya da rage ƙarfin jiyya - fiye da 24 IU / rana. A adadin yau da kullun ya wuce 0.6 IU / kg, - a cikin nau'i na injections 2 a wurare daban-daban. Marasa lafiya da ke karɓar IU 100 ko sama da haka a kowace rana, lokacin da ake maye gurbin insulin, yana da kyau a asibiti. Canja wurin daga wannan magani zuwa wani ya kamata a gudanar dashi karkashin kulawar glucose jini.

Side sakamako:

Tare da keta rikice-rikice na tsarin dosing, abincin, tsananin motsa jiki, cututtuka masu haɗuwa, cututtukan cututtukan jini na iya haɓakawa, a cikin mafi yawan lokuta masu rauni, precoatous da jihar coma.

Wataƙila: halayen rashin lafiyan, rashin gida - redness da itching, janar - halayen anaphylactoid.

Yin hulɗa tare da wasu kwayoyi:

Magunguna ba tare da maganin wasu magunguna ba. Tasirin hypoglycemic yana haɓaka ta hanyar sulfonamides (gami da magunguna na hypoglycemic na baka, sulfonamides), MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic anhydrase inhibitors, ACE inhibitors, ACE inhibitors, NSAIDs (gami da salicylates), anabolic (ciki har da stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + shirye-shirye, pyridoxine, quinidine, quinine, chloroquin Hypoglycemic effects na sosai glucagon, girma hormone, corticosteroids, na baka hana, estrogens, thiazide da madauki diuretics, BCCI, thyroid hormones, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, alli antagonists, diazoxide, morphine, marijuana, nicotine, phenytoin, epinephrine, H1-histamine mai hana masu tallatawa.

Beta-blockers, reserpine, octreotide, pentamidine zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Yanayin ajiya na miyagun ƙwayoyi:

A cikin firiji, a zazzabi na 2-8 ° C (kar a daskare). Ayi nesa da isar yara.

Ranar cikawa: Shekaru 2

Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Yanayin bayardawa daga magunguna: Da takardar sayan magani

Mai masana'anta: ICN Jugoslavija, Yugoslavia