Biphasic insulin lispro shine cakuda dakatarwar rashin lafiyar insulin lispro (shiri insulin-matsakaiciyar aiki) da lispro insulin (shiri insulin cikin sauri). Lyspro insulin shine analog na sake hadewar jikin insulin na mutum, amma akasin haka, yana da ɗayan sashi na proline da kuma ragowar amino acid din a matsayi na 28 da 29 na sarkar insulin B. Lyspro biphasic insulin yana da tasirin anabolic da anti-catabolic, yana daidaita metabolism. A cikin tsokoki da sauran kyallen takarda (banda kwakwalwa), lyspro biphasic insulin yana kara sauyin motsi na amino acid da glucose a cikin kwayar halitta, yana kara yawan abubuwan glycogen, acid din, glycerol, amino acid, yana inganta sinadaran gina jiki, yana hana gluconeogenesis, glycogenolysis, ketogenesis, lipolysis, saki protein, amino acid, yana haɓaka samuwar glycogen daga glucose a cikin hanta, yana ƙarfafa juyar da yawan adadin glucose zuwa mai mai. Lyspro insulin biphasic yayi daidai da insulin na mutum. Lyspro insulin biphasic idan aka kwatanta shi da yanayin insulin na ɗan adam yana faruwa ne ta hanyar farawa da sauri, farkon farawa mafi girma da kuma taƙaitaccen lokacin aikin hypoglycemic (har zuwa 5 hours). Lyspro biphasic insulin yana da babban adadin narkewa da saurin fara aiki (mintuna 15 bayan gudanarwar), yana ba shi damar sarrafawa kai tsaye kafin abinci (mintina 15), ana gudanar da insulin na yau da kullun a cikin rabin sa'a. Za a iya yin amfani da yanayin farawa da yawan shan insulin biphasic insulin ta hanyar zaɓin shafin gudanarwa da sauran abubuwan. Ana lura da mafi girman tasirin insulin lyspro biphasic tsakanin 0.5 da 2.5 hours, tsawon lokacin aiki shine 3 zuwa 4 hours.
Cikakken mamayewa da farawar insulin lyspro biphasic insulin ya dogara da wurin allura (cinya, cinya, buttocks), girman insulin da aka gudanar dashi, maida hankali kan insulin a cikin magunguna da sauran dalilai. Lyspro insulin biphasic an rarraba shi ba daidai ba a fadin kyallen. Lyspro biphasic insulin din bai wuce shingen placental ba kuma ya shiga cikin nono. Lyspro biphasic insulin ya lalace ta hanyar insulinase galibi a hanta da kodan. Kodan ya cire ta (30 - 80%).

Nau'in 1 na ciwon sukari mellitus, musamman tare da rashin haƙuri ga wasu insulins, postprandial hyperglycemia, wanda wasu insulins ba za su iya daidaitawa ba: ƙarancin insulin ƙananan ƙwayar insulin (lalacewar haɓakar insulin cikin gida).
Nau'in na 2 na ciwon sukari mellitus tare da nakasa sauran insulins, tare da juriya ga magungunan maganganu na baka, tare da gudanar da ayyuka, cututtukan cikin zuciya.

Hanyar yin amfani da insulin lyspro biphasic da kashi

Ana gudanar da insulin na Lyspro biphasic insulin a karkashin hanya. An saita kashi akayi daban-daban dangane da matakin glycemia.
Dole ne a yi allurar subcutaneously a cikin kafadu, gindi, gwiwa, da ciki. Ya kamata a sauya wuraren da allurar ta yi amfani da shi don a yi amfani da wurin guda fiye da sau ɗaya a wata. Tare da gudanar da aikin karkashin kasa, dole ne a kula da kar a shigar da jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba.
An yarda da gudanar da aikin insulin na lyspro biphasic insulin.
Idan ya cancanta, ana iya sarrafa insulin na Lyspro biphasic a hade tare da maganin sulfonylureas don gudanar da maganin baka ko tare da tsawan insulin insulin.
A cikin marasa lafiya waɗanda ke fama da yanayin aiki na kodan da / ko hanta, yawan haɓakar insulin yana ƙaruwa, kuma ana iya rage buƙatarta, sabili da haka, ya zama dole a hankali a hankali kula da matakin ƙwayar cuta tare da daidaita sashin insulin.
Wajibi ne a tsayar da lura da sashi da hanyar gudanarwar da aka tsara don nau'in sashi da aka yi amfani dashi.
Lokacin canja wurin marasa lafiya daga insulin-sauri mai aiki na asalin dabba zuwa insulin lyspro biphasic insulin, ana iya buƙatar daidaita sashi. Canza haƙuri ga wani nau'in ko shirya insulin tare da sunan kasuwanci na daban ya kamata ya faru a ƙarƙashin tsananin kulawa na likita. Canjin marasa lafiya da suke karɓar insulin a cikin adadin yau da kullun fiye da 100 IU daga nau'in insulin zuwa wani ya kamata a gudanar da shi a asibiti. Canje-canje a cikin aiki, masana'anta, nau'in, nau'in, da / ko hanyar samar da insulin na iya buƙatar daidaita sashi.
Bayyanar cututtukan cututtukan cututtukan jini a yayin gudanar da aikin insulin na ɗan adam a cikin wasu marasa lafiya na iya zama ƙarancin bayyanawa ko bambanta da waɗanda aka lura yayin gudanar da insulin dabbobi. Tare da daidaituwa na matakan glucose na jini, alal misali, tare da kulawa mai zurfi tare da insulin, duk ko wasu alamu na abubuwan da ke faruwa na hypoglycemia na iya ɓacewa, game da abin da ya kamata a sanar da marasa lafiya. Bayyanar cututtukan cututtukan cututtukan jini na iya zama ƙarancin bayyanawa ko canza su tare da tsawan lokaci na ciwon sukari mellitus, ciwon sukari mai narkewa, magani tare da wasu kwayoyi.
Yin amfani da rashin isasshen allurai ko cire magani, musamman ma a cikin marassa lafiya da ke dauke da ciwon sukari na 1, na iya haifar da cutar sikari da cutar ketoacidosis (yanayin da ke da haɗari ga rayuwa).
Bukatar insulin na iya ƙaruwa tare da damuwa na tunanin mutum, cututtukan cututtuka, haɓaka yawan adadin carbohydrates a cikin abinci, ƙarin amfani da kwayoyi tare da aikin hyperglycemic (glucocorticosteroids, hormones thyroid, thiazide diuretics, maganin hana haihuwa da sauransu).
Bukatar insulin na iya raguwa tare da raguwa a cikin adadin carbohydrates a cikin abinci, hanta da / ko gazawar ƙarancin abinci, rashin isasshen ƙwayar cuta ta adrenal, ƙwaƙwalwar ƙwayar cuta ko glandar thyroid, ƙara yawan aiki na jiki, ƙarin amfani da kwayoyi tare da aikin hypoglycemic (marasa zaɓar beta-blockers, monoamine oxidase inhibitors, sulfonamides da wasu).
Hakanan za'a iya buƙatar gyaran kashi na insulin tare da karuwa a cikin aiki na jiki ko tare da canji a cikin abincin da aka saba.
Marasa lafiya da ciwon sukari na iya dakatar da saurin hypoglycemia da suke ji ta hanyar cin sukari da abinci mai girma a cikin carbohydrates (koyaushe kuna da akalla 20 g na sukari tare da ku). Game da maganin da aka canjawa wuri yakamata ya sanar da likita mai halartar halayen, don warware batun bukatar gyara jiyya.
Lokacin amfani da insulin lyspro biphasic tare da shirye-shirye na ƙungiyar thiazolidinedione, haɗarin haɓakar edema da rauni na zuciya yana ƙaruwa, musamman a cikin marasa lafiya tare da ilimin cututtukan cututtukan zuciya da kasancewar abubuwan haɗari don raunin zuciya.
Tare da hyperglycemia ko hypoglycemia a cikin haƙuri, saurin halayen psychomotor da maida hankali zai iya raguwa, wanda zai iya zama haɗari a cikin yanayi inda waɗannan damar ke da mahimmanci musamman (alal misali, tuki abin hawa, inji). Dole ne marassa lafiya su yi taka-tsantsan don kauce wa ci gaban hypoglycemia ko hyperglycemia lokacin aiwatar da ayyukan da ke buƙatar karuwar hankali da saurin halayen psychomotor (gami da tuki, hanyoyin).Abinda ke da mahimmanci musamman ga marasa lafiya tare da haɓakar haɓakawar hawan jini ko tare da rashi ko alamu masu laushi, masu ƙaddamar da cututtukan jini. A irin waɗannan halayen, likita ya kamata ya kimanta da yiwuwar haƙuri mai yin ayyukan da ke buƙatar karuwar hankali da saurin halayen psychomotor (gami da tuki, hanyoyin)

Tsarin Clinical-Pharmacological Mataki 1

Aikin gona. Cakuda insulin na lyspro - shiryawar insulin cikin sauri-da kuma dakatarwar wani abu na insulin lyspro - shirin insulin mai matsakaici. Lyspro insulin shine analog na analog na insulin na mutum, yana da bambanci da ita ta hanyar jeri na proline da ragowar linoin amino acid a matsayi na 28 da 29 na sarkar insulin B. Yana daidaita metabolism, yana da tasirin anabolic. A cikin tsoka da sauran kyallen takarda (ban da kwakwalwa) yana hanzarta canza yanayin glucose da amino acid a cikin tantanin halitta, yana haɓaka samuwar glycogen daga glucose a cikin hanta, yana hana gluconeogenesis kuma yana ƙarfafa juyar da wuce haddi a cikin mai. Zai dace da insulin na mutum. Idan aka kwatanta shi da insulin ɗan adam na yau da kullun, ana nuna shi ta hanyar farawa da sauri, farkon farawa na ɗaukakakken aiki da gajarta lokacin aikin hailala (har zuwa 5 hours). An fara amfani da hanzarin fara aiki (mintina 15 bayan gudanarwar) ana danganta shi da yawaitar ƙwaƙwalwa kuma yana ba da izinin sarrafa shi nan da nan kafin abinci (mintina 15) - ana gudanar da insulin na yau da kullun cikin minti 30. Zaɓin wurin allurar da sauran dalilai na iya shafar yawan sha da farkon aiwatarwa. Ana lura da mafi girman tasirin tsakanin awa 0,5 da 2.5, tsawon lokacin aikin shine awanni 3-4.

Alamu. Nau'in 1 na ciwon sukari mellitus, musamman tare da rashin haƙuri na sauran insulins, hypglycemia postprandial wanda ba zai iya daidaita wasu insulins ba: matsanancin ƙwayar insulin ƙananan insulin (lalacewar haɓakar insulin na cikin gida). Nau'in 2 na ciwon sukari mellitus - a cikin lokuta na jure maganganun maganganu na baki, a take hakkin sha wasu insulins, yayin gudanar da aiyuka, cututtukan cutuka.

Contraindications Hypersensitivity, hypoglycemia, insulinoma.

Sashi An ƙaddara adadin akayi daban-daban dangane da matakin glycemia.

Ya kamata a gudanar da cakuda 25% na insulin lispro da 75% protamine dakatarwa kawai s / c, yawanci mintuna 15 kafin abinci.

Idan ya cancanta, zaku iya shiga hade tare da shirye-shiryen insulin tsawanta ko tare da maganin sulfonylureas don maganin baka.

Ya kamata a yi allurar s / c a cikin kafadu, kwatangwalo, gindi ko ciki. Dole ne a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata. Tare da kulawar s / c, dole ne a kula da kar a shigar da jini.

A cikin marasa lafiya da keɓaɓɓiyar koda da / ko gazawar hanta, ana ƙaruwa da yaduwar insulin, kuma ana iya rage buƙatarta, wanda ke buƙatar saka idanu sosai game da matakin ƙwayar cuta da kuma daidaita sashin insulin.

Side sakamako. Allergic halayen (urticaria, angioedema - zazzabi, ƙarancin numfashi, saukar karfin jini), lipodystrophy, kurakuran da ke kwance a jiki (yawanci a cikin marasa lafiya waɗanda ba su karɓi insulin a baya ba), hypoglycemia, hypoglycemic coma.

Yawan abin sama da ya kamata. Bayyanar cututtuka: rashin jin daɗi, gumi, gulma, gulma, bugun zuciya, tachycardia, rawar jiki, yunwa, damuwa, damuwar bakin, bakin ciki, ciwon kai, rawar jiki, amai, amai, rashin bacci, tsoro, rashi, tashin hankali, dabi'a, rashin tabbas na ƙungiyoyi, magana mara kyau da hangen nesa, rikicewa, rikicewar jini, rikicewar zuciya.

Jiyya: idan mai haƙuri yana cikin hankali, an sanya dextrose ta hanyar magana da baki, s / c, iv ko iv allurar glucagon ko iv hypertonic dextrose.Tare da haɓakar ƙwayar cuta na ƙwayar cuta, 20 40 ml (har zuwa 100 ml) na maganin 40% na dextrose ana allurar dashi a cikin rafi cikin mai haƙuri har sai mara lafiyar ya fito daga warin.

Haɗa kai. Magunguna ba tare da maganin wasu magunguna ba.

Tasirin hypoglycemic yana haɓaka ta hanyar sulfonamides (gami da magunguna na hypoglycemic na baka, sulfonamides), MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic anhydrase inhibitors, ACE inhibitors, ACE inhibitors, NSAIDs (gami da salicylates), anabolic (ciki har da stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + shirye-shirye, pyridoxine, quinidine, quinine, chloroquin

Hypoglycemic effects na sosai glucagon, girma hormone, corticosteroids, na baka hana, estrogens, thiazide da madauki diuretics, BCCI, thyroid hormones, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, alli antagonists, diazoxide, morphine, marijuana, nicotine, phenytoin, masu hana masu kwafin kwayoyi H₁masu karɓar maganin tsufa.

Beta-blockers, reserpine, octreotide, pentamidine zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Umarni na musamman. Dole ne a kula da hanyar gudanarwar da aka tsara don samar da sashi don amfani dashi.

Lokacin canja wurin marasa lafiya daga insulin mai saurin aiki na asalin dabba zuwa insulin lispro, ana iya buƙatar daidaita sashi. Canja wurin marasa lafiya da suke karɓar insulin a cikin adadin yau da kullun wanda ya wuce 100 IU daga nau'in insulin zuwa wasu ana bada shawarar a gudanar dashi a asibiti.

Bukatar insulin na iya ƙaruwa yayin cuta mai taushi, tare da damuwa na damuwa, tare da haɓaka yawan adadin carbohydrates a cikin abinci, yayin ƙarin ƙwayoyi na ƙwayoyi tare da aikin hyperglycemic (hormones thyroid, GCS, maganin hana haihuwa, thiazide diuretics).

Bukatar insulin na iya raguwa tare da renal da / ko gazawar hanta, tare da rage adadin carbohydrates a cikin abinci, tare da karuwar ƙwayar jiki, yayin ƙarin magunguna tare da aikin hypoglycemic (masu hana MAO, masu hana beta-blockers, sulfonamides).

Halin haɓaka rashin ƙarfi na hypoglycemia zai iya lalata ikon marasa lafiya don taka rawa sosai ga zirga-zirgar ababen hawa, kazalika da kula da injuna da hanyoyin.

Marasa lafiya tare da ciwon sukari na iya dakatar da ɗan ƙaramin ƙin jini na jini da suke ji ta wurin cin sukari ko abinci mai girma a cikin carbohydrates (ana ba da shawarar cewa koyaushe kuna da akalla 20 g na sukari tare da ku). Wajibi ne a sanar da mai halartar likitancin game da cutar siyarwar da aka canza ta don warware batun bukatar gyara.

Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma yana ƙaruwa a cikin na biyu - na uku. Yayin haihuwar yara kuma nan da nan bayan su, buƙatar insulin na iya raguwa sosai.

Rajistar magunguna ta jihar. Buga na hukuma: a cikin vols 2. M: Majalisar Likita, 2009. - Vol 2, part 1 - 568 s., Kashi na 2 - 560 s.

Form sashi

Dakatarwa ga subcutaneous management na 100 IU / ml 3 ml

1 ml na dakatarwa ya ƙunshi

abu mai aiki - insulin lispro 100 IU, (3.5 mg)

magabata: sodium hydrogen phosphate heptahydrate, glycerol, phenol fluid, metacresol, protamine sulfate, zinc oxide (dangane da Zn ++), maganin sodium hydroxide 10% don daidaita pH, ko 10% hydrochloric acid don daidaita pH, ruwa don allura.

Dakatar da farin launi, lokacin da yake tsaye, sai ya zama cikakke, mara launi ko kusan madaukakin launi da farin haske. A sauƙaƙe ana jinkiri cikin nutsuwa tare da girgiza kai

Haihuwa da lactation

Yawancin bayanai game da amfani da insulin lispro a lokacin daukar ciki yana nuna rashin sakamako na rashin amfani da miyagun ƙwayoyi akan ciki, yanayin tayin da jarirai. A lokacin daukar ciki, yana da matukar muhimmanci a kula da kyakkyawan tsari a cikin marassa lafiyar da ke karban maganin insulin. Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma yana ƙaruwa a cikin watanni na biyu da na uku. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam. Marasa lafiya masu ciwon sukari dole ne su sanar da likita game da ciki ko shirinta. A cikin mata masu fama da ciwon sukari mellitus, ana buƙatar daidaita sashin insulin da / ko rage cin abinci yayin shayarwa.
Sakamakon sakamako na insulin lyspro biphasic
Allergic halayen (redness, kumburi, itching a wurin allura, angioedema, jigilar pruritus, wahalar numfashi, ƙarancin zuciya, karuwar gumi, urticaria, zazzabi, rage karfin jini, gajeriyar numfashi), lipodystrophy, edema, tarkace na lokaci mai sauƙi, hauhawar jini, hauhawar jini. (gami da mutuwa).

Yin hulɗa da insulin lispro biphasic tare da sauran abubuwa

Lyspro insulin biphasic ba shi da makamin magani tare da maganin sauran kwayoyi.
Tasirin hypoglycemic na lyspro biphasic insulin an inganta shi ta hanyar sulfonamides (wanda ya hada da magungunan anti-hypoglycemic na bakin, sulfanilamides), inhibitors na carbonic anhydrase, inhibitors na monoamine oxidase (gami da procarbazine, furazolidone, selegiline), angiotensin tana canza antioxididant na antioxididant, magungunan anabolic steroids (ciki har da oxandrolone, stanozolol, methandrostenolone), tetracyclines, captopril, enalapril, b omokriptin, clofibrate, mebendazole, ketoconazole, theophylline, fenfluramine, cyclophosphamide, lithium shirye-shirye, quinidine, octreotide, guanethidine, pyridoxine, tsoka mai amsa sigina antagonists na angiotensin II, chloroquine, quinine, ethanol da etanolsoderzhaschie wajen.
Tasirin hypoglycemic na lyspro biphasic insulin ya raunana ta hanyar somatropin, glucagon, glucocorticosteroids, estrogens, maganin hana haihuwa, jigilar alli na allura, thiazide da loop diuretics, hormones na thyroid, sulfin pyrazone, hepatin, sympathomimetet, antidepressan, beta, antidepresimetet, antidepresimetet, beta kalma, morphine, nicotine, marijuana, phenytoin, chlorprotixen, salbutamol, terbutaline, ritodrin, nicotinic acid, H1-histamine mai hana masu talla, suna samar dnye phenothiazines, isoniazid, epinephrine.
Beta-blockers, octreotide, reserpine, pentamidine zasu iya haɓakawa da raunana tasirin hypoglycemic na lyspro biphasic insulin.
Beta-adrenergic tarewa jami'ai, clonidine, reserpine, lokacin amfani dasu tare da insulin lyspro biphasic, na iya ɓoye bayyanuwar alamun hypoglycemia.
Idan ya zama dole don amfani da magunguna tare da insulin ƙwayar lyspro biphasic, shawarci likitanka.

Yawan abin sama da ya kamata

Idan akwai yawan insulin tare da lyspro biphasic, hauhawar jini, wanda ke tattare da alamomin masu zuwa: gurnani, hutu, karuwar gumi, gumi, tachycardia, palpitations, rawar jiki, damuwa, yunwar, paresthesia a bakin, ciwon kai, fatar fata, nutsuwa, rawar jiki, amai, rashin bacci, yanayi na bacin rai, tsoro, tashin hankali, rashin tsaro na motsi, halin da ba a saba ba, magana da hangen nesa, rikicewa, rashi, rashin wadatar zuciya (na mutuwa th sakamako).A ƙarƙashin wasu yanayi, alal misali, tare da tsawon lokaci na cutar ko tare da sa ido sosai game da ciwon sukari mellitus, alamun alamun hypoglycemia na iya canzawa.
Sau da yawa ana iya dakatar da hypoglycemia ta hanyar haifar da glucose ko sukari, kuma kuna iya buƙatar daidaita sashin insulin, motsa jiki ko abinci. Ana iya aiwatar da gyaran hypoglycemia na matsakaici ta amfani da subcutaneous ko gudanarwa na wucin gadi na glucagon, tare da kara yawan carbohydrates. Muni yanayin hypoglycemia ana tsayar da shi ta wucin gadi ko subcutaneous management na glucagon ko gudanarwar cikin hanji na glucose, tare da cutar sikila, 20 - 40 ml (har zuwa 100 ml) na 40% dextrose bayani ana shigar da shi cikin jijiyoyin wuya har sai mara lafiyar ya fito daga rashin lafiya. Bayan ya dawo da hankali, dole ne a bai wa mai haƙuri abincin da ke da wadataccen abinci a cikin carbohydrates don guje wa sake farfadowa da ƙwanƙwasa jini. Ana buƙatar buƙatar ɗaukar ƙwayar carbohydrate da saka idanu na haƙuri, kamar yadda sake dawo da hypoglycemia mai yiwuwa ne.

Gabaɗaya halayen

Sunan kasuwanci ga miyagun ƙwayoyi shine Humalog Mix. Ya dogara ne akan kwatankwacin insulin mutum. Abun yana da tasirin hypoglycemic, yana taimakawa hanzarta sarrafa glucose, yana kuma tsara yadda za'a fitar da shi. Kayan aiki shine maganin allurar biyu.

Bayan babban abu mai aiki, abun da ke ciki ya kunshi abubuwa kamar:

• metacresol
• glycerol
• sodium hydroxide a cikin hanyar warware (ko hydrochloric acid),
• zinc oxide
• sodium heptahydrate hydrogen phosphate,
• ruwa.

Don amfani da wannan magani, kuna buƙatar alƙawarin likita tare da ingantattun umarnin. Ba a yarda da daidaita sashi ko jadawalin don amfani da kai ba.

Aikin magunguna da alamomi

Ayyukan wannan nau'in insulin yayi kama da na wasu magunguna masu ɗauke da insulin. Penetrating a cikin jiki, abu mai aiki yana hulɗa tare da membranes cell, ta hakan yana ƙarfafa shaye-shaye na glucose.

Tsarin sha daga plasma da rarrabuwa a tsakanin kyallen yana kara hazaka. Wannan shine aikin insulin Lizpro a cikin tsarin sukari.

Hanya ta biyu game da tasirinsa ga jikin mutum shine raguwar haɓakar glucose ta ƙwayoyin hanta. A wannan batun, yawan sukari mai yawa baya shiga cikin jini. Dangane da wannan, ana iya faɗi cewa maganin Humalog yana da tasirin hypoglycemic a cikin matakai biyu.

Wannan nau'in insulin yana aiki da sauri kuma ana kunna minti 15 bayan allura. Wannan yana nufin cewa wannan kayan yana jiki da sauri. Saboda wannan fasalin, an ba shi izinin amfani da maganin kusan kafin abinci.

Yawan sha yana shafar wurin allurar. Sabili da haka, kuna buƙatar yin allura, mai da hankali kan umarnin don maganin.

Yana da mahimmanci a bi shawarwarin insulin na Lizpro yayin yanke shawara game da amfani. Magungunan suna da tasiri mai ƙarfi, saboda haka an ba da izinin amfani dashi gwargwadon alamun. Idan kayi amfani da wannan magani ba da mahimmanci ba, zaku iya haifar da babbar illa ga lafiyar ku.

Alamu game da nadin Humalog sun hada da:

• nau'in farko na ciwon sukari
• hyperglycemia, alamun cututtukan da ba sa ƙazantar da amfani da wasu ƙwayoyi,
• nau'in na biyu na ciwon sukari mellitus (in babu sakamakon sakamakon amfani da kwayoyi don maganin baka),
• shiryawa masu ciwon sukari,
• aukuwa na bazuwar pathological yanayin cewa wahalad da ciwon sukari,
• wani nau'in rashin haƙuri na insulin.

Amma ko da akwai alamun shan wannan magani, likita ya kamata ya bincika mai haƙuri kuma ya tabbata cewa babu wani contraindications da dacewar irin wannan far.

Formaddamar da tsari da abun da ke ciki

Humalog an samar dashi ta hanyar samarda mafita ga sikila (iv) da kuma suttura (s / c): marasa launi, m (a cikin katako mai mil 3, a cikin fakitin bokaye na katako guda 5, a cikin kwali na kwali 1 blister pack, in QuickPen syringe alkalami cikin kwandunan da ke ɗauke da 3 ml na bayani an saka su a cikin kwali na kwali na sirinji 5).

Abun ciki na 1 ml na bayani:

• abu mai aiki: insulin lispro - 100 ME,
• abubuwan taimako: ruwa don allura - har zuwa 1 ml, maganin sodium hydroxide 10% da (ko) maganin hydrochloric acid 10% - har zuwa pH 7-8, sinadarin hydrogen phosphate heptahydrate - 0.00188 g, zinc oxide - don Zn ++ 0.000 0197 g , metacresol - 0.00315 g, glycerin (glycerol) - 0.016 g.

Sashi da gudanarwa

Sashi na magani yana ƙaddara ta likita daban-daban, yin la'akari da tattarawar glucose a cikin jini.

Maganin shine allurar iv - idan ya cancanta, a cikin yanayin cututtukan muni, ketoacidosis, tsakanin ayyukan da bayan aikin, s / c - a cikin hanyar injections ko tsayayyen infusions (ta hanyar famfon insulin) a cikin ciki, buttock, hip ko kafada, ba yana barin samfurin ya shiga cikin jijiyoyin jini. Ana canza wuraren allurar a kowane lokaci, saboda ba a yin amfani da yankin guda fiye da 1 a kowane wata. Bayan gudanarwa, ba za a iya masar da allurar wurin ba.

A kowane yanayi, an saita yanayin gudanarwa daban daban. Ana aiwatar da gabatarwar ne jim kadan kafin abinci, amma an yarda da amfani da miyagun ƙwayoyi jim kadan bayan abinci.

Shiri don gudanar da magunguna

Kafin amfani, ana bincika maganin don rarrabuwar kwayoyin halitta, ɓarna, ƙwaƙwalwa da toka. Yi amfani kawai da launi mara launi da kuma bayyananne a zazzabi a ɗakin.

Kafin allurar, wanke hannuwanku sosai, zaɓi kuma share wurin allurar. Bayan haka, an cire hula daga allura, an cire fata ko tara a cikin babban falo, an saka allura a ciki kuma ana latsa maɓallin. Bayan haka, sai a cire allura kuma a cikin daƙiƙoƙi ana danna matattarar allurar tare da auduga. Ta hanyar amfani da murhun kariya na allura an juye kuma a zubar dashi.

Kafin amfani da Humalog a cikin allurar-alƙalami (injector), ya kamata QuickPen karanta umarnin don amfani.

Ana yin allurar ta IV daidai da aikin asibiti na yau da kullun, alal misali, allurar bolusus ta IV ko ta hanyar jiko. Kulawa akai-akai game da tattarawar glucose na jini yana da mahimmanci.

Kwanciyar hankali na tsarin jiko tare da taro na 0.1-1 IU ta 1 ml na insulin lispro a cikin 5% dextrose ko 0.9% sodium chloride bayani na kwanaki 2 lokacin da aka adana shi a zazzabi a ɗakin.

Don aiwatar da abubuwan infusions, Kwayoyin cuta na Disetronic da Minimed waɗanda aka tsara don insus infusions za'a iya amfani dasu. Yana da mahimmanci a bi umarnin mai ƙira kuma a bi ƙa'idodin asepticism lokacin da ake haɗa tsarin. Kowane kwanaki 2 suna canza tsarin don jiko. Abun da jiko tare da tsohuwar alawar ya tsaya har sai an warware shi. A cikin yanayin ƙarancin yawan glucose a cikin jini, mai haƙuri ya kamata ya nemi likita don la'akari da rage ko dakatar da haɓakar insulin.

Za'a iya saurin tashi cikin haɗarin glucose na jini tare da tsarin da aka makala don jiko ko lalata famfon. Idan ana zargin cin zarafin isar insulin a matsayin dalilin karuwar taro a cikin glucose, mai haƙuri ya kamata ya bi umarnin mai ƙira kuma ya sanar da likita (idan ya cancanta).

Humalog lokacin amfani da famfo ba za'a iya haɗe shi da sauran insulins ba.

Alkalami na insulin QuickPen ya ƙunshi 3 ml na miyagun ƙwayoyi tare da aiki na 100 IU a cikin 1 ml. Ana iya gudanar da rukunin insulin 1-60 na kowane allura. Za'a iya saita kashi tare da daidaituwa na ɗaya. Idan an kafa sassan da yawa, ana iya gyara kashi ba tare da asarar insulin ba.

Ya kamata mai haƙuri ɗaya ya yi amfani da shi, ya kamata a yi amfani da sabon allura don kowane allura. Kar a yi amfani da allurar in wani ɓangaren sassan sa ya lalace ko ya karye. Mai haƙuri yakamata a ɗauka allura mai mahimmanci koda na asara ko lalacewa.

Marasa lafiya marasa rauni da hangen nesa ko asarar hangen nesa ba a ba da shawarar yin amfani da allurar ba tare da taimakon mutanen da suke gani sosai don horar da su ba.

Kafin kowane allura, yana da mahimmanci a tabbatar cewa ranar karewa da aka nuna akan lakabin bai ƙare ba kuma cewa madaidaicin nau'in insulin yana cikin allurar. A wannan batun, ba da shawarar cire alamar daga ciki ba.

Launin launi na maɓallin saurin saurin maɓallin sikirin da ke cikin QuickPen yana launin toka, yana dacewa da launi na tsiri akan tambarin sa da nau'in insulin da ake amfani dashi.

Kafin yin amfani da injector, kana buƙatar tabbatar cewa allura ta haɗu da ita. Bayan amfani, an cire allurar kuma an zubar dashi. Ba za a iya ajiye alkairin sirinji tare da allura da aka haɗe da shi ba, saboda wannan na iya haifar da kumburin iska ya tashi a cikin ƙwayar magunguna.

Lokacin da za a ƙera adadin ƙwayar magani wanda ya wuce raka'a 60, ana yin allura biyu.

Don bincika ragowar insulin a cikin kabad ɗin, kuna buƙatar nuna allurar tare da ƙarshen allura sama da ganin adadin raka'a insulin akan sikelin da za'a riƙe katako mai ɗaukar hoto. Ba'a yi amfani da wannan alamar don saita kashi ba.

Don cire hula daga allurar, kana buƙatar jan shi. Idan wata matsala ta taso, a hankali juya maɓallin agogo a agogo da kuma agogo, sannan a ja.

Kowane lokaci kafin allura, suna bincika abincin insulin, tunda ba tare da shi ba zaku iya samun insulin kadan ko mai yawa. Don bincika, cire maɗaurin murfin ciki da na ciki, ta juyawa maɓallin kashi, an saita raka'a 2, an jera allurar zuwa sama kuma ta buga mai riƙe da katako don duk iska ta tattara a cikin ɓangaren na sama. Sannan danna maɓallin kashi har sai ya tsaya kuma lambar 0 ta bayyana a cikin taga alamar kashi. Riƙe maɓallin a cikin wurin da aka sake, a hankali ƙidaya zuwa 5, a wannan lokacin wani ɓoɓin insulin yakamata ya bayyana a ƙarshen allura. Idan kwararar insulin bai bayyana ba, ana maye gurbin allura da sabon kuma ana yin aikin sake.

Gudanar da magunguna

• Cire kwatangwalo daga alkalami na syringe
• tare da swab moistened tare da barasa, shafa diski na roba a ƙarshen abin riƙe da katako,
• saka allura a cikin hula kai tsaye a jikin allurar kuma ka goge shi har sai ya kasance gaba ɗaya.
• ta juyawa maɓallin kashi, an saita adadin raka'a,
• Cire hula daga allura kuma sanya shi a karkashin fata,
• tare da yatsa, danna maɓallin kashi har sai ya daina gaba ɗaya. Don shigar da cikakken kashi, riƙe maɓallin kuma sannu a hankali ƙidaya zuwa 5,
• an cire allura daga karkashin fata,
• duba alamar maganin - idan yana da lamba 0 a kansa, an shigar da kashi ɗin gabaɗaya,
• a hankali sanya murfin waje a allura kuma cire shi daga allurar, sannan a jefa shi,
• saka hula a aljihun syringe.

Idan mai haƙuri ya yi shakkar cewa ya ba da cikakkiyar magani, ba za a sake bayar da ƙarin magani ba.

Side effects

• mafi yawan lokuta: hypoglycemia (a lokuta masu rauni, yana iya bauta wa ci gaban haila, a lokuta na musamman - mutuwa),
• mai yiwuwa: lipodystrophy, halayen rashin lafiyan gida - kumburi, redness ko itching a wurin allurar,
• da wuya: halayen halayen rashin lafiyan jiki - haɓaka mai yawa, yawan zafin jiki, tachycardia, hauhawar jini, gazawar numfashi, zazzabi, angioedema, urticaria, itching cikin jiki baki ɗaya.

Umarni na musamman

Canja wurin mara lafiya zuwa wani suna na daban ko nau'in insulin ana aiwatar dashi karkashin kulawar likita. Idan kun canza hanyar samarwa, nau'in, nau'in, alama da / ko aiki, za'a iya buƙatar daidaita sashi.

Kwayar cutar cututtukan da ke nuna ci gaban hypoglycemia na iya zama ƙasa da ma'ana tare da kulawa mai zurfi tare da insulin, kasancewar dogon lokaci na ciwon sukari mellitus, cututtukan da tsarin juyayi na cutar kanjamau, da jiyya na lokaci daya tare da kwayoyi, misali beta-blockers.

Alamar farkon cutar hypoglycemia a cikin marasa lafiya tare da halayen hypoglycemic bayan sauyawa daga insulin dabba da aka samo zuwa insulin mutum na iya zama mai rauni mai rauni ko bambanta da waɗanda suke da insulin da suka gabata yayin maganin.

A cikin yanayin rashin daidaituwa na rashin daidaituwa ko amsawar hypoglycemic, ci gaban asarar sani, coma, ko kuma farkon mutuwa yana yiwuwa. Yin amfani da miyagun ƙwayoyi a cikin isasshen allurai ko dakatar da jiyya, musamman ga nau'in ciwon sukari na mellitus, na iya haifar da haɓakar cututtukan fata da ketoacidosis masu ciwon sukari, waɗanda ke haifar da barazanar rayuwar mai haƙuri.

A ƙarancin koda da na hepatic, zai iya rage buƙatar insulin, wanda ke da alaƙa tare da rage yawan aiki na insulin da tsarin gluconeogenesis. A cikin lalacewar hanta na hanta (saboda karuwar juriya na insulin), damuwa na damuwa, cututtukan cututtuka, haɓaka yawan adadin carbohydrates a cikin abinci, buƙatar insulin na iya ƙaruwa.

A yanayin canje-canje a cikin abincin da aka saba da ƙwarewar aiki, ana buƙatar daidaita sashi na miyagun ƙwayoyi. Lokacin yin motsa jiki na jiki kai tsaye bayan cin abinci, haɓakar haɗarin haɓakar haɓakawa zai yiwu. Sakamakon magunguna na analogues ana amfani da insulin na insulin mutum, yawan jini na iya haɓaka a baya bayan allura fiye da lokacin amfani da insulin ɗan adam mai narkewa.

Lokacin da ake tsara shirin insulin tare da taro na 40 IU a cikin 1 ml a cikin murfin, ba shi yiwuwa a kuɓutar da insulin daga cikin kicin tare da yawan insulin na 100 IU a cikin 1 ml ta amfani da sirinji don gudanar da insulin tare da taro 40 IU a cikin 1 ml.

Lokaci guda tare da shirye-shiryen insulin tare da kwayoyi na rukunin thiazolidinedione yana ƙara haɗarin haɓakar edema da rauni na zuciya, musamman a kan tushen cututtukan cututtukan zuciya da kuma gaban abubuwan haɗari don rauni na zuciya.

Marasa lafiya yayin aikin jiyya yakamata suyi hankali lokacin tuki motoci da gudanar da ayyukan haɗari waɗanda ke buƙatar ƙara kulawa da saurin halayen psychomotor.

Hulɗa da ƙwayoyi

Sakamakon magunguna / abubuwa akan lyspro insulin a hade magani:

• abubuwan da ke faruwa na phenothiazine, nicotinic acid, lithium carbonate, isoniazid, diazoxide, chlorprotixene, thiazide diuretics, antattara maganin tricyclic, beta-2-adrenergic agonists (terbutaline, salbutamol, ritodrin, da sauransu), glandonjin-kansa tsananin tsananin hypoglycemic sakamako,
• angiotensin II receptor antagonists, octreotide, angiotensin-juyar da enzyme inhibitors (enapril, captopril), wasu magungunan antidepressants (monoamine oxidase inhibitors), maganin rigfanilamide, salicylates (acetylsalicylic acid, da sauransu, phenolic kwayoyi, tetragenurolincgg hycg, hypog hycgg ethanol da ethanol-kwayoyi masu dauke da kwayoyi, beta-blockers: ƙara yawan tasirin tasirin tasirinsa.

Ba a hade insulin Lyspro tare da insulin dabbobi ba.

Kafin shan wasu kwayoyi, yana da muhimmanci a nemi likita. A kan shawarwarinsa, ana iya amfani da miyagun ƙwayoyi a hade tare da insulin ɗan adam mai amfani da tsayi ko tare da nau'ikan nau'in sulfonylureas.

Misalin Humalog sune Iletin I na yau da kullun, Iletin II na yau da kullun, Inutral SPP, Inutral HM, Farmasulin.

Sharuɗɗan hutu na kantin

An sake shi ta hanyar takardar sayan magani.

An sami kuskure a cikin rubutun? Zaɓi shi kuma latsa Ctrl + Shigar.

Duk da cewa masana kimiyyar sun sami nasarar maimaita kwayar insulin, wanda aka samar a jikin mutum, aikin kwayar halittar har yanzu ya zama a hankali ba saboda lokacin da ake bukata ba don shiga cikin jini. Magunguna na farko na inganta aikin shine Humalog insulin. Ya fara aiki tuni mintina 15 bayan allura, don haka sukari daga jini aka canza shi zuwa kyallen takarda a kan kari, har ma hyperglycemia na ɗan gajeren lokaci bai faruwa.

Yana da mahimmanci a sani! Takaitaccen labari wanda masana ilimin kimiyar lissafi suka shawarce su Ci gaba da Ciwon sukari! Abin kawai ya zama dole a kowace rana.

Idan aka kwatanta da insulins na mutum da aka kirkiro a baya, Humalog yana nuna kyakkyawan sakamako: a cikin marassa lafiya, ana rage canzawar yau da kullun cikin kashi 22%, glycemic fihirisa yana inganta, musamman da rana, kuma da alama rashin jinkiri na raguwar hauhawar jini ya ragu. Sakamakon azumin, amma tsayayyen aiki, ana ƙara amfani da wannan insulin a cikin ciwon sukari.

Bruef umarnin

Umarni game da amfani da insulin Humalog abu ne mai cike da ƙima, kuma sassan da suke bayyana illolin sakamako da kwatance don amfani da sakin layi sama da ɗaya. Bayani mai tsawo da ke rakiyar wasu magunguna ana samun su ta hanyar marasa lafiya a matsayin gargaɗi game da haɗarin shan su. A zahiri, komai kishi ne daidai: babban umarni, - shaidar da yawa gwaji cewa magani samu nasarar tsayayya.

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

Cutar sankarau shine sanadin kusan kashi tamanin cikin ɗari na duka raunin da aka yanke. Mutane 7 daga 10 ne ke mutuwa sakamakon kamuwa da jijiyoyin zuciya da kwakwalwa. A kusan dukkanin lokuta, dalilin wannan mummunan ƙarshen shine guda - sukari na jini.

Sugar zai iya kuma ya kamata a rushe, in ba haka ba komai. Amma wannan ba ya warkar da cutar da kanta, amma kawai tana taimakawa wajen yaƙar bincike, kuma ba dalilin cutar ba.

Kadai magani wanda aka bayar da shawarar hukuma don magance cututtukan cututtukan fata kuma ana amfani da shi ta hanyar endocrinologists a cikin aikin su shine wannan.

Tasirin maganin, wanda aka lasafta bisa ga daidaitaccen hanyar (adadin marasa lafiyar da suka murmure zuwa jimlar yawan marasa lafiya a cikin rukuni na mutanen 100 waɗanda suka sami kulawa) sun kasance:

• Normalization na sukari - 95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya - 90%
• Rabu da cutar hawan jini - 92%
• Thearfafa rana, inganta bacci da dare - 97%

Masana'antu ba kungiyar kasuwanci ba ce kuma an tallafa musu da tallafin jihar. Saboda haka, yanzu kowane mazaunin yana da damar.

An amince da Humalogue don amfani da shi sama da shekaru 20 da suka gabata, kuma yanzu ba shi da haɗari a ce wannan insulin ɗin yana da lafiya a gwargwado daidai. An yarda dashi don amfani da tsofaffi da yara, za'a iya amfani dashi a duk halayen, tare da raɗaɗin rashin haila: nau'in 1 da nau'in ciwon sukari na 2, tiyata.

Janar bayani game da Humalogue:

Daga cikin sakamako masu illa, cututtukan cututtukan zuciya da cututtukan ƙwayar cuta ana lura dasu galibi (1-10% na masu ciwon sukari). Kasa da 1% na marasa lafiya suna haɓakar lipodystrophy a wurin allurar. Mitar wasu halayen masu rauni ba su wuce 0.1% ba.

Abu mafi mahimmanci game da Humalog

A gida, ana gudanar da Humalog ta hanyar amfani da maɓallin sirinji ko. Idan za a kawar da cututtukan hawan jini, za a iya samun damar gudanar da maganin a cikin asibitin. A wannan yanayin, sarrafa sukari akai-akai wajibi ne don kauce wa yawan zubar da ruwa.

Abubuwan da ke aiki na miyagun ƙwayoyi shine insulin lispro. Ya bambanta da hormone mutum a cikin tsari na amino acid a cikin kwayoyin. Irin wannan canjin baya hana masu karɓar tantanin halitta tantance kwayoyin halittar, don haka suna iya sanya sukari cikin kansu cikin sauƙi. Humalogue ta ƙunshi kawai monomers na insulin - guda, kwayoyin da ba a haɗa su ba. Saboda wannan, ana shan shi da sauri kuma a ko'ina, yana fara rage sukari da sauri fiye da insulin al'ada.

Humalog magani ne da ya fi guntu aiki, misali, ko. Dangane da rarrabuwa, ana nufin insulin analogues tare da aikin ultrashort. An fara aikinsa cikin sauri, game da mintina 15, don haka masu ciwon sukari ba dole su jira har sai miyagun ƙwayoyi zasu yi aiki ba, amma zaku iya shirya abinci nan da nan bayan allura. Godiya ga irin wannan ɗan gajeriyar hanya, ya zama mafi sauƙi ga shirya abinci, kuma haɗarin manta abinci bayan allura ya ragu sosai.

Don ingantaccen iko na glycemic, jami'ai masu saurin aiki yakamata a haɗe su da amfani na wajibi. Iyakar abin da ya keɓance shine amfani da famfo na insulin akan aikin mai gudana.

Yankan zaɓi

Humalog sashi ya dogara da dalilai da yawa kuma an ƙaddara daban-daban ga kowane masu ciwon sukari. Yin amfani da tsari na yau da kullun ba da shawarar ba, saboda suna ƙaruwa da diyyar ciwon sukari. Idan mara lafiya ya manne da karancin abincin carbohydrate, kashi na Humalog na iya zama kasa da tsarin gudanarwa na yau da kullun. A wannan yanayin, ana bada shawara don amfani da insulin mai rauni mai rauni.

Ultrashort hormone yana ba da tasiri sosai. Lokacin canzawa zuwa Humalog, ana ƙididdige ƙwayar farkonsa azaman 40% na ɗan gajeren insulin da aka yi amfani dashi a baya.Dangane da sakamakon glycemia, an daidaita sashi. Matsakaicin buƙata don shirye-shiryen kowane yanki burodi shine raka'a 1-1.5.

Tsarin allura

Kalmar humalogue ce kafin kowane abinci, akalla sau uku a rana . Game da sukari mai yawa, ana ba da izinin poplings tsakanin manyan injections. Umarni don amfani yana bada shawarar yin lissafin adadin insulin da ake buƙata dangane da carbohydrates da aka shirya don abinci na gaba. Kimanin mintina 15 ya kamata ya wuce daga allura zuwa abinci.

Dangane da sake dubawa, wannan lokacin ba shi da yawa, musamman da rana, lokacin jure insulin yana ƙasa. Yawan shaye shaye ne na mutum, ana iya yin amfani da shi ta amfani da maimaita matakan glucose na jini kai tsaye bayan allura. Idan an lura da yanayin rage sukari da sauri fiye da umarnin, umarnin lokacin da abinci ya kamata ya ragu.

Humalog shine ɗayan magunguna mafi sauri, saboda haka yana da dacewa don amfani dashi azaman taimakon gaggawa don ciwon sukari idan mai haƙuri yana cikin haɗari.

Lokacin aiki (gajere ko tsawo)

An lura da girman insulin ultrashort a cikin mintuna 60 bayan gudanarwarsa. Tsawan lokacin da ya dogara da sashi, mafi girma shi ne, tsawon lokacin da yake haifar da rage sukari, a matsakaici - kimanin awa 4.

Humalog mix 25

Don kimantawa daidai da tasirin Humalog, dole ne a auna glucose bayan wannan lokacin, yawanci ana yin wannan kafin abinci na gaba. Ana buƙatar ma'aunin farko idan ana zargin hypoglycemia.

Likita na Kimiyyar Kimiyya, Shugaban Cibiyar Nazarin Diabetology - Tatyana Yakovleva

Na yi shekaru da yawa ina nazarin ciwon sukari. Yana da ban tsoro yayin da mutane da yawa suka mutu, har ma da yawa suna zama masu rauni saboda cutar sankara.

Na yi hanzarin ba da labari mai daɗi - Cibiyar Binciken Endocrinological na Kwalejin Kimiyya ta Rasha ta sami nasarar inganta maganin da ke warkar da ciwon sukari gaba daya. A yanzu, ingancin wannan magani yana gab da kashi 98%.

Wani labari mai dadi: Ma'aikatar Kiwon Lafiya ta yi tallafi wanda zai rama babban farashin magunguna. A Rasha, masu ciwon sukari har zuwa 2 ga Maris samun shi - Don kawai 147 rubles!

Shortarancin gajeren lokacin Humalog ba matsala bane, amma fa'idodin maganin. Godiya gareshi, marasa lafiya da ke dauke da cutar sankarar mellitus ba su da yiwuwar fuskantar hauhawar jini, musamman da daddare.

Humalog Mix

Baya ga Humalog, kamfanin harhada magunguna Lilly Faransa yana samar da Humalog Mix. Cakuda ne na lyspro insulin da kuma sulfate protamine. Godiya ga wannan haɗin, lokacin farawa na hormone yana kasancewa cikin sauri, kuma tsawon lokacin aiki yana ƙaruwa sosai.

Humalog Mix yana samuwa a cikin taro biyu:

Amfanin kawai irin waɗannan kwayoyi shine hanya mafi sauƙi na allurar rigakafi. Sakamakon ciwon sukari mellitus tare da yin amfani da shi ya fi muni da lokacin yin amfani da insulin na asibiti da kuma amfani da Humalog na yau da kullun, sabili da haka, don Yara Humalog Mix ba a amfani da su .

An wajabta wannan insulin:

1. Masu ciwon sukari waɗanda ba sa iya yin lissafin ɗayan kai-tsaye ko kuma yin allura, alal misali, saboda hangen nesa mara kyau, gurguwa ko rawar jiki.
2. Marasa lafiya tare da rashin hankali.
3. Tsofaffi marasa lafiya da ke da yawan rikice-rikice na ciwon sukari da ƙarancin hangen nesa idan ba su son yin karatu.
4. Masu ciwon sukari masu fama da cuta ta 2, idan har ana samar da nasu hormone.

Kula da ciwon sukari tare da Humalog Mix yana buƙatar tsayayyen tsarin abinci, kayan snack a tsakanin abinci. An ba shi damar cin abinci har zuwa 3 XE don karin kumallo, har zuwa 4 XE don abincin rana da abincin dare, kusan 2 XE don abincin dare, da 4 XE kafin lokacin bacci.

Analogs na Humalog

Lyspro insulin a matsayin abu mai aiki yana ƙunshe ne kawai a cikin Humalog na asali. Magungunan kusa-da-kullun sune (bisa ga aspart) da (glulisin). Wadannan kayan aikin suma yanada matattakala, dan haka bashi da mahimmanci wanda zaba. Dukkansu suna da haƙuri da kyau kuma suna samar da raguwa cikin sauri a cikin sukari.A matsayinka na doka, ana ba da fifiko ga maganin, wanda za'a iya samun kyauta a asibiti.

Sauyawa daga Humalog zuwa misalinsa ana iya zama dole idan akwai rashin lafiyan halayen. Idan mai ciwon sukari ya manne da tsarin karancin abinci mai karafa, ko kuma yawanci yana da matsalar rashin haihuwa, zai fi dacewa mutum yayi amfani da mutum maimakon insulin ultrashort.

Tabbatar koya! Shin kuna tsammanin kulawa da kwayoyin hana daukar ciki da insulin shine hanya daya tilo da za'a kula da sukari? Ba gaskiya bane! Kuna iya tabbatar da wannan da kanku ta hanyar fara amfani da shi.

Kwayar halittar cikin jikin ɗan adam ta kasance.
Shiri: HUMALOG®
Aiki mai guba na miyagun ƙwayoyi: insulin lyspro
Lullukin ATX: A10AB04
KFG: insulin ɗan adam-gajere
Lambar yin rijista: P A'a 015490/01
Ranar rajista: 02.02.04
Mai mallaka reg. acc.: LILLY FRANCE S.A.S.

Maganin maganin allura abu ne mara kyau, mara launi.

1 ml
insulin lispro *
100 IU

Mahalarta: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, ruwa d / da, hydrochloric acid acid na 10% da sodium hydroxide bayani na 10% (don ƙirƙirar matakin pH da ake buƙata).

3 ml - katako (5) - blister (1) - fakitoci na kwali.

* Sunan kasa-da-kasa na mallakar ta wanda WHO ta ba da shawarar, a cikin Tarayyar Rasha, an karɓi fassarar sunan ƙasa - insulin lispro.

Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Humalog na aikin magunguna

Kwayar halittar cikin jikin ɗan adam ta kasance. Ya bambanta da na ƙarshen gaba a cikin jerin amino acid a cikin matsayi na 28 da 29 na sarkar insulin B.

Babban tasirin maganin shine ƙayyadadden tsarin glucose metabolism. Bugu da kari, yana da tasirin anabolic. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

A cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2, lokacin amfani da insulin lyspro, ƙwaƙwalwar ƙwayar cuta wanda ke faruwa bayan cin abincin ya fi raguwa idan aka kwatanta da insulin ɗan adam mai narkewa. Ga marasa lafiya da ke karbar gajeriyar motsa jiki da na basal, ya zama dole a zabi kashi biyu na insulins don samun ingantaccen matakan glucose na jini a duk tsawon rana.

Kamar yadda yake tare da duk shirye-shiryen insulin, tsawon lokacin aikin lyspro insulin na iya bambanta a cikin marassa lafiya daban-daban ko a lokuta daban-daban a cikin mai haƙuri ɗaya kuma ya dogara da kashi, wurin allura, samarda jini, zazzabi jiki da aikin jiki.

Halayen magunguna na insulin lyspro a cikin yara da matasa sunyi kama da waɗanda aka lura da su a cikin manya.

A cikin marasa lafiya da masu ciwon sukari na nau'in 2 ke karɓar iyakar abubuwan da suka samo asali na maganin sulfonylurea, ƙari na insulin lyspro yana haifar da raguwa mai yawa a cikin haemoglobin glycosylated.

Kulawar insulin Lyspro a cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2 yana haɗuwa tare da raguwa a cikin adadin abubuwan da ke haifar da cutar rashin ƙwaƙwalwar ƙwaƙwalwa ta nocturnal.

Amsar glucodynamic ga isulin lispro bai dogara da aikin kodan ko hanta ba.

An nuna insulin Lyspro yayi daidai da insulin na mutum, amma aikinta yana faruwa da sauri kuma yana tsawan lokaci.

Lyspro insulin yana nunawa ta hanyar farawa da sauri (game da mintina 15), kamar yadda Yana da babban adadin sha, kuma wannan yana ba ka damar shigar da shi kai tsaye kafin abinci (mintuna 0-15 kafin abinci), ya bambanta da insulin gajere na al'ada (minti 30-45 kafin abinci). Lyspro insulin yana da ɗan gajeren lokacin aiki (2 zuwa 5 hours) idan aka kwatanta da insulin ɗan adam na al'ada.

Pharmacokinetics na miyagun ƙwayoyi.

Tsotsa da rarrabawa

Bayan sc gwamnatin, insulin Lyspro yana da sauri kuma ya kai Cmax a cikin jini na jini bayan mintuna 30-70. Vd na insulin lyspro da sauran insulin na mutum suna daidai kuma suna cikin kewayon 0.26-0.36 l / kg.

Tare da gudanarwar ins na T1 / 2 na insulin, lyspro yana kusan awa 1. Marasa lafiya tare da rashin haihuwa da kuma hepatic insufficiency suna riƙe da babban adadin yawan ƙwayar lyspro idan aka kwatanta da insulin ɗan adam na al'ada.

Sashi da hanyar gudanar da magani.

Likita ya kayyade maganin daban-daban, gwargwadon bukatun mai haƙuri. Ana iya gudanar da Humalog jim kaɗan kafin abinci, idan ya cancanta - nan da nan bayan cin abinci.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin.

Ana gudanar da Humalog sc a cikin hanyar injections ko kuma a cikin hanyar kara jiko sc jiko ta amfani da famfon. Idan ya cancanta (ketoacidosis, m rashin lafiya, lokacin tsakanin aiki ko bayan aikin) Za a iya shigar da Humalog cikin / in.

Ya kamata a gudanar da SC zuwa kafada, cinya, gindi ko ciki. Yakamata a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata. Lokacin da s / zuwa gabatarwar miyagun ƙwayoyi Humalog, dole ne a kula don hana shigar da miyagun ƙwayoyi cikin jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba. Yakamata a horar da mai haƙuri cikin madaidaiciyar dabarar.

Dokoki don gudanar da maganin Humalog

Shiri don gabatarwa

Maganin maganin Humalog yakamata ya zama amintacce kuma mara launi. Baƙin amfani da gajimare, ko tauri ko ta ɗanɗano launi, ko kuma idan an gano daskararru na gani a ciki, to baza ayi amfani dashi ba.

Lokacin shigar da katun a cikin alkairin sirinji (alkalami-injector), riƙe allura da kuma yin allurar insulin, ya wajaba a bi umarnin mai ƙira da ke haɗe da kowane alkalami mai sirinji.

2. Zaɓi wani wuri don allura.

3. Alluba don magance fata a wurin allurar.

4. Cire hula daga allura.

5. Gyara fata ta hanyar shimfida shi ko ta hanyar adana babban falo. Saka allura daidai da umarnin don amfani da alkairin sirinji.

6. Latsa maɓallin.

7. Cire allura kuma a hankali matsi da allurar site na da yawa saika. Kar a shafa wurin allurar.

8. Yin amfani da kabarin allura, kwance allurar kuma ka lalata shi.

9. Wajibi ne a sauya wuraren da ake yin allurar don kada a yi amfani da wurin iri ɗaya ba sau ɗaya ba sau 1 a kowane wata.

Gudanar da insulin na insulin

Ya kamata a aiwatar da allurar rigakafin Humalog daidai da yadda ake yin allurar asibiti na yau da kullun, alal misali, gudanarwar allurar cikin gida ko yin amfani da tsarin jiko. Haka kuma, galibi ya zama dole a sarrafa matakin glucose a cikin jini.

Tsarin jiko tare da tarawa daga 0.1 IU / ml zuwa 1.0 IU / ml insulin lispro a cikin 0.9% sodium chloride bayani ko 5% dextrose bayani shine barga a zazzabi a daki na awanni 48.

P / C insulin jiko ta amfani da famfon insulin

Don jiko na ƙwayar Humalog, Ana iya amfani da famfunan rage ƙwayar cuta da ƙananan ƙwayoyin cuta don jiko na insulin. Dole ne a bi umarnin mai zuwa tare da famfo. Ana canza tsarin jiko a kowane sa'o'i 48. Lokacin da aka haɗa tsarin jiko, ana kiyaye ka'idojin aseptic. Idan aka sami labarin ainahin yanayin da ake ciki, jikan ya tsaya har sai abin da ya faru ya warware. Idan akwai matakan glucose masu yawa a cikin jini sau da yawa, to lallai ne ku sanar da likitanka game da wannan kuma kuyi la'akari da rage ko dakatar da haɓakar insulin. Rashin ƙwayar famfo ko tarko a cikin tsarin jiko na iya haifar da hauhawar hauhawar matakan glucose. Idan ana zargin cin zarafin insulin, dole ne a bi umarnin kuma, idan ya cancanta, sanar da likita. Lokacin amfani da famfo, ƙwayar Humalog bazai hade da sauran insulins ba.

Tasirin sakamako Humalog:

Sakamakon sakamako wanda ya danganta da babban sakamakon maganin: hypoglycemia. Mai tsananin rashin ƙarfi na iya haifar da asarar hankali (ƙin jinin haila) kuma, a lokuta na musamman, ga mutuwa.

Allergic halayen: halayen rashin lafiyan gida na yiwuwa - redness, kumburi ko itching a wurin allura (yawanci yakan ɓace cikin daysan kwanaki ko makonni), halayen rashin lafiyan ƙabilanci (na faruwa ba sau da yawa, amma sun fi tsanani) - naƙasa ta haɓaka, amaƙar fata, amai, amai, zazzaɓi, gajere na numfashi, rage karfin jini, tachycardia, haɓaka mai ɗaci. Mummunan lokuta na halayen rashin lafiyan halayen na iya zama barazanar rayuwa.

Sauran: lipodystrophy a wurin allurar.

Yi amfani da lokacin daukar ciki da lactation.

Har zuwa yau, ba a gano tasirin insulin Lyspro akan ciki ko lafiyar ɗan tayi / jariri ba. Babu wani binciken da ya dace da karatun da akayi.

Manufar insulin jiyya a lokacin daukar ciki shine don kula da isasshen iko na glucose matakan a cikin marasa lafiya da insulin-dogara da sukari mellitus ko tare da ciwon sukari na gestational. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki. A lokacin daukar ciki, marasa lafiya da ciwon sukari suna buƙatar saka idanu sosai game da matakan glucose na jini, kazalika da saka idanu na asibiti gaba ɗaya.

A cikin marasa lafiya da ciwon sukari mellitus yayin shayarwa, ana buƙatar daidaita sashin insulin da / ko rage cin abinci.

Umarnin musamman don amfani da Humalog.

Canja wurin mara lafiya zuwa wani nau'in ko samfurin insulin yakamata a gudanar dashi karkashin kulawar likita. Canje-canje a cikin aiki, alama (masana'anta), nau'in (misali, Na yau da kullun, NPH, Tape), nau'in (dabba, ɗan adam, analog na insulin mutum) da / ko hanyar samarwa (insulin maimaita insulin ko insulin asalin dabbobi) yana iya buƙatar kashi canje-canje.

Yanayin da alamun farkon faɗakarwar cututtukan cututtukan jini na iya zama marasa ma'ana kuma ƙasa da ƙima sun haɗa da ci gaba da wanzuwar ciwon sukari, maganin insulin mai narkewa, cututtukan ƙwayar cuta a cikin cututtukan sukari, ko magunguna, kamar beta-blockers.

A cikin marasa lafiya waɗanda ke fama da hypoglycemic bayan canjawa daga insulin dabbobi da aka samo zuwa insulin na mutum, alamun farko na hypoglycemia na iya zama ƙarancin bayyanawa ko bambanta da waɗanda suka ɗanɗana da insulin da suka gabata. Rashin daidaituwa na hypoglycemic ko hyperglycemic halayen na iya haifar da asarar sani, coma, ko mutuwa.

Inarancin allurai ko dakatarwar magani, musamman tare da insulin-insulin-da ke fama da cutar sankara, na iya haifar da hyperglycemia da ketoacidosis mai ciwon sukari, yanayin da ke haifar da barazanar rayuwa ga mai haƙuri.

Bukatar insulin na iya raguwa a cikin marasa lafiya tare da gazawar koda, haka kuma a cikin marasa lafiya da gazawar hanta a sakamakon raguwa cikin ayyukan gluconeogenesis da metabolism metabolism. Koyaya, a cikin marasa lafiya tare da gazawar hanta na rashin ƙarfi, karuwar juriya na insulin na iya haifar da karuwa a cikin insulin.

Bukatar insulin na iya ƙaruwa tare da cututtuka masu raɗaɗi, damuwa na damuwa, tare da karuwa da adadin carbohydrates a cikin abincin.

Hakanan ana iya buƙatar daidaita sikelin idan aikin mai haƙuri ya karu ko kuma abincin da yake ci yana canzawa. Yi motsa jiki nan da nan bayan cin abinci yana kara haɗarin hawan jini.Sakamakon magunguna na insulin analogues na aiki da sauri shine idan hypoglycemia ya haɓaka, to zai iya haɓaka bayan allura a baya fiye da lokacin allurar ɗan adam mai narkewa.

Yakamata a gargadi mara lafiya cewa idan likita ya tsara shirin insulin tare da maida hankali 40 IU / ml a cikin murfin, to kada a dauki insulin daga kicin din tare da yawan insulin na 100 IU / ml tare da sirinji don allurar insulin tare da tattara 40 IU / ml.

Idan ya zama dole a dauki wasu kwayoyi a lokaci guda kamar Humalog, mai haƙuri ya kamata ya nemi likita.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Tare da hypoglycemia ko hyperglycemia da ke da alaƙa da ƙarancin allurar allurar rigakafi, tauye ikon yin hankali da saurin halayen psychomotor mai yiwuwa. Wannan na iya zama haɗari ga haɗari mai haɗari (gami da tuki motoci ko aiki tare da kayan aiki).

Dole ne marasa lafiya su yi hankali don guje wa hypolycemia yayin tuki. Wannan yana da mahimmanci musamman ga marasa lafiya waɗanda ke da raunin ji ko rashin jin alamun bayyanar alamun bayyanar cutar hypoglycemia, ko kuma a cikin abin da cututtukan cututtukan jini suka zama ruwan dare. A cikin waɗannan yanayin, wajibi ne don tantance yiwuwar tuƙi. Marasa lafiya tare da ciwon sukari na iya kawar da tsinkayen kai a jiki ta hanyar shan gulukos ko abinci mai yawa a cikin carbohydrates (ana ba da shawarar cewa ko da yaushe kuna da 20 g of glucose tare da ku). Mai haƙuri ya kamata ya sanar da likitan halartan game da ƙaddamarwar cututtukan jini.

H hullog hulɗa tare da wasu kwayoyi.

Humalog's hypoglycemic sakamako yana rage ta hanyar hana haihuwa, corticosteroids, shirye-shiryen hodar iblis thyroid, danazol, beta2-adrenergic agonists (gami da rhytodrin, salbutamol, terbutaline), tricyclic antidepressants, thiazide diuretics, chlorprotixenic acid, nikloracin acid, ni abubuwan da aka samo asali na phenothiazine.

Hypoglycemic mataki Humalog karuwa beta-blockers, ethanol da etanolsoderzhaschie kwayoyi, anabolic steroids, fenfluramine, guanethidine, tetracyclines, na baka hypoglycemic jamiái, salicylates (msl, acetylsalicylic acid), sulfonamides, Mao hanawa, ACE hanawa (captopril, enalapril), octreotide, antagonists masu karɓar angioensensin II.

Kada a haɗa Humalog tare da shirye-shiryen insulin dabbobi.

Ana iya amfani da Humalog (a karkashin kulawa na likita) a hade tare da insulin ɗan adam mai amfani da tsayi ko a hade tare da wakilai na maganin hypoglycemic na baki, abubuwan samo asali na sulfonylurea.

Sharuɗɗan yanayin ajiya na miyagun ƙwayoyi Humalog.

Lissafi B. Ya kamata a adana magungunan ba tare da isar yara ba, a cikin firiji, a zazzabi na 2 ° zuwa 8 ° C, kada a daskare. Rayuwar shelf shine shekaru 2.

Ya kamata a adana magani a cikin ɗakin zazzabi a 15 ° zuwa 25 ° C, an kiyaye shi daga hasken rana kai tsaye da zafi. Rayuwar shelf - ba fiye da kwanaki 28 ba.

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Humalogue . Yana ba da ra'ayi daga baƙi zuwa rukunin yanar gizon - masu cin wannan magani, da kuma ra'ayoyin kwararrun likitocin game da amfani da Humalog a aikace. Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Analogs na Humalog a gaban wadatattun analogues na tsarin ana amfani dasu. Yi amfani da shi don lura da nau'in 1 da nau'in ciwon sukari na 2 na sukari (wanda ke dogara da insulin-insulin-da kuma cututtukan da ba na insulin-suba) a cikin manya, yara, har ma lokacin daukar ciki da lactation. Abun da magani.

Humalogue - analog na insulin na ɗan adam, ya bambanta da shi ta hanyar jeri na proline da linsine amino acid na raguwa a matsayi na 28 da 29 na sarkar insulin B. Idan aka kwatanta da shirye-shiryen insulin gajere, lyspro insulin ana nuna shi da sauri da kuma ƙarshen tasirin, wanda shine saboda karɓar sha daga ƙwaƙwalwar subcutaneous saboda adana tsarin monomeric na kwayoyin insulin lyspro a cikin maganin. Farawar aiki shine mintina 15 bayan gudanarwar subcutaneous, matsakaicin sakamako shine tsakanin awa 0.5 zuwa awa 2.5, tsawon lokacin aikin shine sa'o'i 3-4.

Humalog Mix shine DNA - sake zama analog na insulin ɗan adam kuma wani cakuda ne wanda aka yi shi wanda ya ƙunshi bayani na insulin lyspro (analog mai aiki da insulin na ɗan adam) da dakatarwar insulin na lyspro pro-matsakaici na ɗan adam.

Babban aikin insulin lyspro shine tsari na metabolism metabolism. Bugu da ƙari, yana da tasirin anabolic da anti-catabolic akan ƙoshin jikin mutane daban-daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

Lyspro insulin + excipients.

Cikakken kamfani da kuma farawar insulin ya dogara da shafin allura (ciki, cinya, gindi), kashi (girman insulin allurar), da kuma tattarawar insulin a cikin shiri. An rarraba shi ba tare da daidaituwa ba a cikin kyallen takarda. Bai ƙetare katangar ƙwarya ba kuma cikin madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya cire shi - 30-80%.

• type 1 ciwon sukari mellitus (insulin-dogara), gami da tare da rashin haƙuri ga sauran shirye-shiryen insulin, tare da hyperglycemia postprandial waɗanda ba za a iya gyara su ta hanyar wasu shirye-shiryen insulin ba, ƙarancin insulin ƙananan insulin (lalacewar insulin na cikin gida),
• nau'in ciwon sukari na 2 na ciwon sukari (wanda ba shi da insulin-insulin) ba: tare da juriya ga wakilai na yawan maganganu na baki, kazalika da shan wahala na sauran shirye-shiryen insulin, hyperglycemia na rashin daidaituwa, yayin aiki, cututtukan da ke shudewa.

Magani don gudanarwar ciki da karkara na sarrafa 100 IU a cikin kwatin 3 ml da aka haɗa cikin allurar QuickPen ko sirinji na alkalami.

Dakatarwa don ƙaddamarwa na 100 IU a cikin kundin 3 ml a cikin kundin QuickPen ko alkalami na alkalami (Humalog Mix 25 da 50).

Sauran nau'ikan sashi, koda Allunan ko kuma kwansonsu, babu su.

Umarnin don amfani da hanyar amfani

An saita sashi daban daban. Ana gudanar da insulin na Lyspro subcutaneously, intramuscularly ko intravenously 5-15 mintuna kafin cin abinci. Singleaya daga cikin kashi shine raka'a 40, an yarda da wuce haddi a cikin lokuta na musamman. Tare da monotherapy, ana gudanar da insulin Lyspro sau 4-6 a rana, a hade tare da shirye-shiryen insulin tsawan lokaci - sau 3 a rana.

Ya kamata a gudanar da miyagun ƙwayoyi a ƙarƙashin ƙasa.

M ciki da miyagun ƙwayoyi Humalog Mix an contraindicated.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin.

Ya kamata a allurar da kashi a cikin kafada, cinya, gindi ko ciki. Yakamata a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata. Lokacin da s / zuwa gabatarwar miyagun ƙwayoyi Humalog, dole ne a kula don hana shigar da miyagun ƙwayoyi cikin jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba.

Lokacin shigar da kundin a cikin injection insulin kuma yana ɗaukar allura kafin gudanarwar insulin, dole ne a kiyaye umarnin mai ƙirar insulin naúrar gudanar da aikin.

Dokoki don gabatarwar miyagun ƙwayoyi Humalog Mix

Shiri don gabatarwa

Nan da nan kafin amfani da shi, yakamata a jujjuya murfin Humalog Mix a cikin tafin hannun ya ninka sau goma kuma ya girgiza, ya juya 180 ° kuma sau goma don sake farfadowa da insulin har sai yayi kama da ruwa mai hade ko madara mai kama da juna. Shake da ƙarfi, kamar yadda wannan na iya haifar da kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi. Don sauƙaƙe hadawa, kundin ya ƙunshi karamin dutsen ado. Bai kamata a yi amfani da miyagun ƙwayoyi ba idan ya ƙunshi flakes bayan haɗuwa.

Yadda ake gudanar da maganin

1. Wanke hannu.
2. Zaɓi wurin yin allura.
3. Bi da fata tare da maganin rigakafi a wurin allurar (tare da allurar kai, daidai da shawarar likita).
4. Cire takalmin kariya daga allura.
5. Gyara fata ta hanyar jan shi ko adon babban falo.
6. Saka allura a ƙarƙashin kuma aiwatar da allurar daidai da umarnin don amfani da alkairin sirinji.
7. Cire allura kuma a hankali matsi wurin allurar don aan seconds. Kar a shafa wurin allurar.
8. Yin amfani da matattarar kariya ta allura, kwance allurar sai ka lalata shi.
9. Saka hula a aljihun syringe.

• hypoglycemia (tsananin hypoglycemia na iya haifar da asarar hankali kuma, a lokuta na musamman, ga mutuwa),
• jan launi, kumburi, ko ƙaiƙayi a wurin allura (yawanci yakan ɓace cikin aan kwanaki ko makonni, a wasu yanayi waɗannan halayen ana iya haifar dasu ta hanyar dalilan da basu da nasaba da insulin, alal misali, haushi na fata ta hanyar allura ko rashin allurar),
• na sarrafa itching
• wahalar numfashi
• karancin numfashi
• raguwa a cikin karfin jini,
• samarin
• ƙara yin gumi
• haɓakar lipodystrophy a wurin allurar.

• hawan jini,
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Haihuwa da lactation

Har zuwa yau, ba a bayyana sakamakon insulin Lyspro akan ciki ba ko kuma yanayin tayin da jariri.

Manufar insulin far a lokacin daukar ciki shine kula da isasshen kulawar glucose. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki.

A cikin marasa lafiya da ciwon sukari mellitus yayin shayarwa, ana buƙatar daidaita sashin insulin da / ko rage cin abinci.

Hanyar gudanarwa da aka yi nufin amfani da shi don amfani da nau'in insulin lyspro ya kamata a kiyaye shi sosai. Lokacin canja wurin marasa lafiya daga shirye-shiryen insulin mai sauri-sauri na asalin dabba zuwa insulin lispro, ana iya buƙatar daidaita sashi. Canja wurin marasa lafiya da suke karɓar insulin a cikin kashi-kashi na yau da kullun da suka wuce raka'a 100 daga nau'in insulin zuwa wani an bada shawarar a kai su asibiti.

Bukatar insulin na iya ƙaruwa yayin cutar, tare da damuwa na ruhi, tare da haɓaka yawan adadin carbohydrates a cikin abinci, yayin ƙarin ƙwayoyi na ƙwayoyi tare da aikin hyperglycemic (hormones thyroid, glucocorticoids, hana maganin hana haihuwa, thiazide diuretics).

Bukatar insulin na iya raguwa tare da renal da / ko gazawar hanta, tare da raguwa a cikin adadin carbohydrates a abinci, tare da ƙara yawan motsa jiki, yayin ƙarin ƙarin magunguna tare da aikin hypoglycemic (inhibitors na MAO, masu hana beta-blockers, sulfonamides).

Ana iya aiwatar da gyaran hypoglycemia a cikin wani yanayi mai mahimmanci ta amfani da i / m da / ko s / c gudanar da glucagon ko iv na glucose.

Tasirin hypoglycemic na Lyspro yana haɓaka ta hanyar MAO inhibitors, masu hana beta-blockers, sulfonamides, acarbose, ethanol (barasa) da ethanol dauke da kwayoyi.

Tasirin hypoglycemic na Lyspro insulin ya rage ta glucocorticosteroids (GCS), hodar iblis, maganin hana haihuwa, thiazide diuretics, diazoxide, antidepressants na tricyclic.

Beta-blockers, clonidine, reserpine na iya rufe alamun bayyanar cututtuka na hypoglycemia.

Analogs na miyagun ƙwayoyi Humalog

Tsarin analogues na mai aiki abu:

• Lyspro insulin
• Humalog Mix 25,
• Humalog Mix 50.

Analogs ta ƙungiyar magunguna (insulins):

• HM Penfill,
• Aikin MS,
• B-Insulin S.Ts. Barcelona Chemie,
• Berlinsulin H 30/70 U-40,
• Berlinsulin H 30/70 alkalami,
• Berlinsulin N Basal-40,
• Berlinsulin N Basal Pen,
• Berlinsulin N Na al'ada U-40,
• Berlinsulin N Al'adala,
• Asarar insulin C,
• Isofan insulin Gasar Cin Kofin Duniya,
• Iletin
• Insulin Tape SPP,
• Insulin c
• Insulin na alade yana tsarkakakken babban ɗanɗani MK,
• Insumanci Comb,
• Ciki na ciki,
• Yakin Duniya na Yankin,
• Combinsulin C
• Mikstard 30 NM Penfill,
• Monosuinsulin MK,
• Monotard
• Pensulin,
• Protafan HM Shawnigan,
• Protafan MS,
• Rinsulin
• UltMard NM,
• Homolong 40,
• Homorap 40,
• Humulin.

Idan babu analogues na miyagun ƙwayoyi don ƙwayar abu mai aiki, zaku iya danna hanyoyin da ke ƙasa zuwa cututtukan da maganin da ya dace ya taimaka daga kuma duba magungunan analogues na maganin warkewa.

Pharmacodynamics

Lyspro insulin magani ne mai yawan haɓaka na ƙungiyar insulins da ke gajeriyar aiki. Abubuwan da yake aiki shine insulin lispro, analog na sakewa na deoxyribonucleic acid (DNA) na insulin mutum, wanda ya bambanta da shi ta hanyar sake samar da amino acid a matsayi na 28 da 29 a cikin sarkar B ta kwayar insulin.

Baya ga daidaita metabolism na glucose, insulin lyspro yana da tasirin anabolic da anti-catabolic akan ƙoshin jikin mutum. A cikin tsoffin ƙwayoyin tsoka, yana ba da gudummawa ga haɓaka abubuwan glycogen, glycerol da mai mai, haɓaka amfani da amino acid, da haɓaka haɗarin furotin. A lokaci guda, akwai hana aiwatar da ayyukan glycogenolysis, ketogenesis, gluconeogenesis, lipolysis, sakin amino acid, da kuma furotin furotin.

Lyspro insulin da insulin na mutum suna daidaitawa, amma tsohon yana da yanayin farawa da gajeriyar aiki. Sakamakon yawan ƙwayar cuta, tasirin hypoglycemic na Lyspro insulin ya bayyana 1/4 h bayan gudanarwa, wanda ya ba da damar amfani da miyagun ƙwayoyi nan da nan kafin abinci.

Tsawon lokacin da miyagun ƙwayoyi ya kasance daga sa'o'i 2 zuwa 5. Yana iya bambanta duka a cikin marasa lafiya daban-daban kuma a cikin haƙuri ɗaya a cikin lokuta daban-daban. Canjin lokacin aiki yana tasiri da kashi, wurin allura, zafin jiki, samarda jini da aikin jiki na mai haƙuri.

Idan aka kwatanta da insulin ɗan adam mai narkewa, yin amfani da insulin lyspro na iya rage yawan lokuttan cututtukan cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, mafi mahimmanci rage hyperglycemia wanda ke faruwa a cikin marasa lafiya da nau'in 1 da nau'in ciwon sukari na 2 bayan cin abinci.

A cikin manya, yara da matasa, ana lura da irin wannan maganin ta insulin lyspro.

Amsar glucodynamic ta insulin lispro ba ta dogara da yanayin koda na mai haƙuri ko aikin hanta ba.

Alamu don amfani

Amfani da insulin Lyspro an nuna shi don lura da nau'ikan cututtukan sukari a cikin manya da yara:

• dogaro da insulin (nau'in ciwon sukari na 1): wanda ya haɗa da marasa haƙuri da sauran shirye-shiryen insulin, tare da haɓaka wasu magunguna waɗanda ba za a iya gyara su ta hanyar insprandial insulin ba (bayan cin abinci), ƙarancin insulin ƙananan insulin (lalacewar insulin na cikin gida),
• rashin wadatar insulin (nau'in ciwon sukari na 2): idan akwai wani kwarin gwiwar wasu maganganu na baki, da kuma lalacewa ta hanyar sauran shirye-shiryen insulin, yayin ayyukan tiyata, cututtukan da ke faruwa, cututtukan bacci marasa inganci.

Lyspro insulin, umarnin don amfani: hanyar da sashi

Maganin insulin Lyspro an yi shi ne don gudanarwar SC da iv. Ana yin allurar ne da farko kafin mintina 15 kafin abinci ko kuma bayan abinci.

A karkashin fata, ana iya gudanar da maganin a cikin bolus ko a matsayin dogon allurar subcutaneous ta amfani da famfon insulin.

A cikin wata jijiya, ana nuna kulawa da insulin lyspro don ketoacidosis, cututtukan m, tsakanin aiki ko bayan tiyata.

Zazzabi na allurar maganin zai dace da zazzabi dakin.

Kafin gudanarwa, ya kamata a kimanta abubuwan da ke cikin kicin ko murfin gani don dacewa. Ruwan zai kasance mai haske kuma mara launi. Idan ya zama mai duhu, mai kauri, mai launin toka ko kuma idan an samo barbashi na kasashen waje a ciki - dole ne a zubar da mafita.

Likita ya kayyade gwargwado da yanayin gudanarwar insulin Lyspro daban-daban, gwargwadon yawan glucose a cikin jini.

Gudun ƙarƙashin ƙasa tare da alkalami mai saƙo

P / c Insulin Lyspro ana iya shigar da shi cikin cikin kashi mai ciki na ciki, kafada, cinya ko gindi, guje wa mafita yana shiga cikin jini. Yakamata a riƙa yin atisaye da allura akai-akai, da nisantar yin amfani da wurin guda fiye da sau 1 a kowane wata. Bayan allurar, bai kamata a sanyaya wurin da allura ba.

Dole ne a yi amfani da katako tare da EndoPen Syringe alkalami waɗanda masana'antu suka yi ta Bagging Gangan Technology Co. Ltd. (China), tunda an saita daidaituwar allurar ta musamman don allon alkalami da aka nuna.

Lokacin da yake rubuta magani, likita dole ne ya koya wa mai haƙuri dabarar sarrafa kai na allurar sc, kuma ya tabbata cewa an yi wa mai haƙuri daidai da insulin da ikon yin amfani da alkairin sirinji.

Dole a shigar da kundin a cikin sirinji mai allura kuma a sanya shi a cikin ƙaƙƙarfan ƙa'idoji da umarnin mai ƙira don amfani da alkairin sirinji.

Matakan-mataki-mataki don gudanarwa ga wani kashi na insulin lispro:

1. A wanke hannu sosai.
2. Zaɓi wurin yin allura.
3. Shirya fata a wurin allura daidai da shawarar likita.
4. Cire takalmin kariya daga allura.
5. Gyara fata.
6. Saka allura a karkashin fata, aiwatar da allurar daidai da umarnin alkalami na alkairin.
7. Cire allurar, a hankali danna wurin allurar tare da swam auduga na dan lokaci kadan, kada a shafa wurin allurar.
8. Cire allurar tare da hula ta madogara daga ciki ka zubar da shi.
9. Saka hula a aljihun syringe.

Gudun ƙarƙashin ƙasa tare da famfo na insulin

Ana iya amfani da fam na insulin tare da tsarin don ci gaba da gudanar da aikin insulin na insulin tare da alamar CE. Kafin kowane gabatarwar, ya wajaba don tabbatar da dacewa da wani keɓaɓɓen famfo da kiyaye cikakkiyar ƙa'idodin umarnin don aikin sa. Yi amfani da tafki da catheter dace don famfo, canza kit ɗin don gudanarwa insulin. A cikin yanayin zubar da jini, dole ne a dakatar da sarrafa magunguna har sai abin ya warware. Idan kun sami raguwar glucose mai yawa a cikin jini, ya kamata ku nemi shawarar likita nan da nan. Wajibi ne a yi la'akari da rage kashi ko dakatar da gudanarwar insulin lyspro.

Rushewa a cikin samar da mafita saboda tsarin allurar da aka toshe ko kuma rashin lafiyar iskar insulin zai iya sa mara haƙuri ya hanzarta ƙara yawan glucose. Sabili da haka, a cikin 'yar alamar tuhuma game da kasancewar duk wani abin da ya faru a cikin tsarin, wajibi ne a bi umarnin kuma a sanar da likita idan ya cancanta.

Kada a haɗa insulin Lyspro tare da wasu abubuwan insulins lokacin amfani da famfo.

Maganin cikin ciki

Ana iya sarrafa insulin cikin ciki ko dusar ruwa, tare da sanya idanu akai-akai na yawan haɗuwar glucose jini.

Don jiko, ana iya narkewar insulin lyspro a cikin maganin 5% dextrose bayani ko 0.9% sodium chloride bayani.Lokacin da maida hankali na insulin a cikin maganin jiko yana cikin kewayon 0.1-1 IU ta 1 ml, maganin da aka shirya ya kasance tsayayye na sa'o'i 48 a yawan zafin jiki na ɗakin.

Tasiri a kan ikon tuka motoci da abubuwa masu rikitarwa

A lokacin amfani da insulin Lyspro lokacin tuki motoci ko aiki tare da hadaddun hanyoyin, yana da mahimmanci don la'akari da yiwuwar keta saurin abubuwan halayen psychomotor da kuma ikon tattara hankali yayin haɓaka hypo-ko hyperglycemia saboda rashin isasshen tsarin kulawa. An ba da shawarar ta musamman musamman ga marasa lafiya da keɓancewar yawan haihuwar hypoglycemia, tare da rage ƙarfin jin alamun bayyanar cututtukan hypoglycemia ko kuma rashi. Wajibi ne a gudanar da kimantawar mutum na dacewa da tuki.

Nunawa game da Insulin Lyspro

A kan shafukan yanar gizo na musamman a yau babu sake dubawa game da insulin Lyspro daga marasa lafiya da danginsu.

Masana sun ba da shawarar yin amfani da ƙarancin ƙarancin ƙwaƙwalwa mai ma'ana, ana insulin lispro, a cikin yanayin haɗarin rayuwar masu ciwon sukari wanda ke haifar da cututtukan cututtukan da ba a sarrafa su ba (mai ciwon sukari ketoacidosis), maimakon daidaitaccen farji (saurin iv na insulin na yau da kullun). Tunda a wannan yanayin yana aiki da sauri fiye da insulin na mutum kuma yana hana ci gaba iv na mafita, yawanci yana buƙatar asibiti mai haƙuri a cikin sashin kulawa mai zurfi.

Farashin insulin lispro a cikin magunguna

Farashin insulin Lyspro don kunshin wanda ya ƙunshi katako 1 tare da mafita na iya zama daga 252 rubles, katako 5 daga 1262 rubles, kwalban 1 (10 ml) - daga 841 rubles.

Ilimi: Na farko Jami'ar Likita ta Jihar Moscow da aka sanya wa suna da I.M. Sechenov, ƙwararren "General Medicine".

Bayanai game da miyagun ƙwayoyi an samar da su, an bayar da su ne don dalilai na bayanai kuma baya maye gurbin umarnin hukuma. Kai magani yana da haɗari ga lafiya!

A lokacin rayuwa, matsakaicin mutum ya samar da kasa da ruwa biyu na yau.

Cutar da ta fi kamari ita ce cutar Kuru. Wakilan ƙabilar Fore a New Guinea kawai ba su da lafiya tare da ita. Mai haƙuri ya mutu saboda dariya. An yi imanin cewa sanadin cutar tana cin kwakwalwar mutum.

A yunƙurin fitar da mara lafiya, likitoci sukan yi nisa sosai. Don haka, alal misali, wani Charles Jensen a cikin shekarun daga 1954 zuwa 1994. ya tsira fiye da 900 aikin cirewar neoplasm.

Ya kasance hakan yana haɓaka jiki da oxygen. Koyaya, wannan ra'ayi ya gurbata. Masana kimiyya sun tabbatar da cewa hargo, mutum yana sanya kwantar da hankali kwakwalwa da inganta aikinta.

Kowane mutum ba wai kawai ɗan yatsan yatsa bane, amma kuma yare.

Ko da zuciyar mutum ba ta doke ba, to zai iya rayuwa na tsawon lokaci, kamar yadda masanin kifin nan na ƙasar Jan Revsdal ya nuna mana. “Motar” sa ya tsaya na tsawon awanni 4 bayan masun ɗin ya ɓace kuma ya faɗi cikin dusar ƙanƙara.

Idan kayi murmushi sau biyu kawai a rana, zaku iya rage karfin jini da rage hadarin bugun zuciya da bugun jini.

Lokacin da masoya suka sumbaci, kowannensu yana asarar 6.4 kcal a minti daya, amma a lokaci guda suna musayar kusan nau'ikan kwayoyin 300 daban-daban.

Akwai syndromes na likita masu ban sha'awa, irin su sha'awar abubuwa. A cikin ciki na haƙuri ɗaya da ke fama da wannan matsala, an gano abubuwa 2500 na ƙasashen waje.

Magunguna da yawa an fara tallata su azaman magunguna. Misali, a farko, an siyar da Heroin azaman maganin tari. Kuma likitoci sun ba da shawarar yin amfani da cocaine a matsayin maganin hana haihuwa da kuma hanyar wadatar da haƙuri.

Miliyoyin ƙwayoyin cuta ana haihuwar su, suna rayuwa kuma suna mutuwa cikin gutuwarmu. Ana iya ganin su kawai da girman girma, amma idan sun taru, za su dace da kofin kofi na yau da kullun.

Likitocin hakora sun bayyana ne kwanan nan. A cikin ƙarni na 19, aikin maikatar gashi ne na al'ada don fitar da hakoran da ke da lafiya.

An kirkiro firikwensin farko a karni na 19. Ya yi aiki a kan injin tururi kuma yana da niyyar kula da cutar mace.

Yawancin mata suna iya samun ƙarin jin daɗi daga tunanin kyakkyawan jikinsu a cikin madubi fiye da jima'i. Don haka, mata ku yi ƙoƙari don jituwa.

Jinin mutum "yana gudana" ta cikin jiragen ruwa a ƙarƙashin matsanancin matsin lamba, kuma idan an keta mutuncin sa, zai iya harba har zuwa mita 10.

Polyoxidonium yana nufin magungunan immunomodulatory. Yana aiki akan wasu sassan tsarin na rigakafi, ta haka yana ba da gudummawa ga haɓaka kwanciyar hankali na.

Umarnin don amfani

Don guje wa mummunan sakamako daga amfani da insulin Lizpro, dole ne a bi umarnin sosai game da wannan magani.

Sashi na miyagun ƙwayoyi ya dogara da fasali da yawa. Wannan yana shafar shekarun mai haƙuri, kamuwa da cutar da tsananin ƙarfinsa, cututtukan da suka dace, da sauransu. Saboda haka, ƙayyade kashi shine aikin likita.

Amma ƙwararren na iya yin kuskure, saboda haka ya kamata a sanya idanu ta hanyar bincika sukari na jini da daidaita tsarin kulawa. Hakanan mai haƙuri ya kamata ya kula da lafiyar sa kuma ya sanar da likita game da duk mummunan halayen jikin mutum ga miyagun ƙwayoyi.

Ana amfani da Humalog sosai a ƙarƙashin. Amma ba kamar yawancin kwayoyi iri ɗaya ba, ana yarda da allurar ciki har ma da fitowar insulin a cikin jijiya. Ya kamata a yi allurar cikin ciki tare da halartar mai bada kiwon lafiya.

Mafi kyawun wurare don allurar subcutaneous shine yankin cinya, yankin kafada, gindi, raunin ciki. Ba a yarda da gabatarwar miyagun ƙwayoyi cikin yanki ɗaya ba, saboda wannan yana haifar da lipodystrophy. Ana buƙatar motsi mai ƙarfi a cikin yankin da aka tsara.

Ya kamata a yi allura a lokaci daya na rana. Wannan zai ba da izinin jiki don daidaitawa da samar da ci gaba da haɗuwa da insulin.

Yana da matukar muhimmanci a yi la’akari da matsalolin rashin haƙuri (ban da ciwon suga). Saboda wasu daga cikinsu, sakamakon wannan kayan zai iya gurbata ko zuwa sama. A wannan yanayin, za ku sake yin lissafin kashi ɗin. A dangane da wasu cututtukan, likita na iya haramta yin amfani da Humalog gabaɗaya.

Syringe alkalami bidiyo:

Siffofin hulɗa tare da wasu kwayoyi

Muhimmin fasali na kowane magani shine yardarsa da wasu kwayoyi. Dole ne likitoci suyi maganin cututtukan da yawa a lokaci guda, saboda wanda ya zama dole a hada liyafar ta magunguna daban-daban. Wajibi ne a tsara tsarin ilimin don kada magungunan su toshe matakan junan su.

Wani lokaci ana buƙatar amfani da kwayoyi waɗanda zasu iya gurbata aikin insulin.

Ana inganta tasirinta idan, ban da shi, mai haƙuri ya ɗauki nau'ikan magungunan:

• Clofibrate
• Ketoconazole,
• MAO masu hanawa
• sulfonamides

Idan ba za ku iya karɓar shan su ba, dole ne ku rage kashi na Humalog ɗin da aka gabatar.

Abubuwa masu zuwa da gungun wakilai na iya rage tasirin maganin a cikin tambaya:

• estrogens
• nicotine
• magungunan hormonal don hana haihuwa,
• Glucagon.

Saboda waɗannan kwayoyi, ingancin Lizpro na iya raguwa, don haka likita dole ne ya ba da shawarar haɓaka sashi.

Wasu kwayoyi suna da tasirin da ba a iya faɗi. Suna iya haɓaka da rage ayyukan abu mai aiki. Waɗannan sun haɗa da Octreotide, Pentamidine, Reserpine, beta-blockers.

Cost da analogues na miyagun ƙwayoyi

Jiyya tare da Insulin Lyspro yana da tsada. Kudin kunshin ɗaya na irin wannan magani ya bambanta daga 1800 zuwa 200 rubles. Saboda girman tsada ne wasu lokuta marasa lafiya ke tambayar likita don maye gurbin wannan magani tare da analog tare da mafi tsada mai tsada.

Akwai da yawa analogues na wannan magani. An wakilta su ta hanyar nau'ikan saki daban-daban, na iya bambanta a cikin abubuwan da ke ciki.

Daga cikin manyan za'a iya ambata:

Zaɓin magunguna don maye gurbin irin wannan insulin ya kamata a danƙa wa kwararrun likita.

Sashi da gudanarwa

Matsakaicin Humalog Mix 50 ana ƙaddara ta likita daban-daban, gwargwadon bukatun mai haƙuri. Ana iya sarrafa Humalog® Mix 50 nan da nan kafin abinci, kuma idan ya cancanta, dama bayan abinci. Ya kamata a gudanar da miyagun ƙwayoyi kawai a ƙarƙashin ƙasa! M ciki na magani na miyagun ƙwayoyi Humalog Mix 50 contraindicated. Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin. Tsarin sarrafa insulin shine mutum!

Ya kamata a bai wa allurar da ruwa a kafada, cinya, gindi ko ciki. Dole ne a sauya wuraren allurar don kada a yi amfani da wurin iri ɗaya ba kusan sau ɗaya a wata ba.

Tare da subcutaneous management na Humalog® Mix 50, dole ne a kula da kar a shigar da jini lokacin allura. Bayan allurar, bai kamata a sanyaya wurin da allura ba. Yakamata a horar da marassa lafiya yadda ya kamata.

Tsawancin maganin zai iya bambanta sosai daga mutum zuwa mutum kuma a lokuta daban-daban a cikin mutum guda. Matsayin aikin Humalog® Mix 50 ya dogara da kashi, wurin allura, wadatar jini, zazzabi da aikin mai haƙuri.

Nan da nan kafin a yi amfani da shi, yakamata a ɗaura murfin Humalog® Mix 50 a tsakanin tafin hannu ya ninka sau goma kuma ya girgiza, ya juya 180 °, sau goma don sake ɗibar insulin har sai ya zama ruwan da zai zama ruwansa. Maimaita wannan tsari har abun da ke ciki ya hade. Kada ku girgiza sosai, saboda wannan na iya haifar da bayyanar kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi.

Na'urar katuwar katako ba ta bada izinin haɗa abubuwan da ke cikin su tare da wasu abubuwan insulins kai tsaye a cikin katun da kanta. Ba a cika cika abubuwan alaƙar katako ba.

Ya kamata a bincika abubuwan da ke cikin katako a koyaushe, kuma bai kamata a yi amfani da su a gaban clots, flakes ko dangane da adon farin barbashi mai kauri zuwa ƙasan ko ganuwar katun, ba shi matte gama.

Wajibi ne a bi shawarar mai ƙira don kowane alkalami na kowane mutum yayin cika kwalin, ɗaukar allura, da allura Humalog® Mix 50.

Zaɓi wurin yin allura.

Shafar fata a wurin allurar daidai da umarnin.

Cire takalmin kariya daga allura.

Gyara fata ta tattara ta cikin babban falo.

Saka allura ƙarƙashin abu bisa umarnin.

Cire allura kuma a hankali matsi wurin allurar tare da swam na auduga na daƙiƙoƙi kaɗan. Kar a shafa wurin allurar.

Ta yin amfani da matattarar m abin da ke cikin allurar, kwance allurar kuma a jefa ta daidai da ƙa'idodin aminci.

Wajibi ne a sauya wuraren allurar don kada a yi amfani da yankin iri ɗaya fiye da sau ɗaya a wata.

Contraindications

• hawan jini,
• mutum haƙuri zuwa ga abubuwan da miyagun ƙwayoyi.

Sashi da gudanarwa

Sashi na magani yana ƙaddara ta likita daban-daban, yin la'akari da tattarawar glucose a cikin jini.

Maganin shine allurar iv - idan ya cancanta, a cikin yanayin cututtukan muni, ketoacidosis, tsakanin ayyukan da bayan aikin, s / c - a cikin hanyar injections ko tsayayyen infusions (ta hanyar famfon insulin) a cikin ciki, buttock, hip ko kafada, ba yana barin samfurin ya shiga cikin jijiyoyin jini. Ana canza wuraren allurar a kowane lokaci, saboda ba a yin amfani da yankin guda fiye da 1 a kowane wata. Bayan gudanarwa, ba za a iya masar da allurar wurin ba.

A kowane yanayi, an saita yanayin gudanarwa daban daban. Ana aiwatar da gabatarwar ne jim kadan kafin abinci, amma an yarda da amfani da miyagun ƙwayoyi jim kadan bayan abinci.

Shiri don gudanar da magunguna

Kafin amfani, ana bincika maganin don rarrabuwar kwayoyin halitta, ɓarna, ƙwaƙwalwa da toka. Yi amfani kawai da launi mara launi da kuma bayyananne a zazzabi a ɗakin.

Kafin allurar, wanke hannuwanku sosai, zaɓi kuma share wurin allurar. Bayan haka, an cire hula daga allura, an cire fata ko tara a cikin babban falo, an saka allura a ciki kuma ana latsa maɓallin. Bayan haka, sai a cire allura kuma a cikin daƙiƙoƙi ana danna matattarar allurar tare da auduga. Ta hanyar amfani da murhun kariya na allura an juye kuma a zubar dashi.

Kafin amfani da Humalog a cikin allurar-alƙalami (injector), ya kamata QuickPen karanta umarnin don amfani.

Ana yin allurar ta IV daidai da aikin asibiti na yau da kullun, alal misali, allurar bolusus ta IV ko ta hanyar jiko. Kulawa akai-akai game da tattarawar glucose na jini yana da mahimmanci.

Kwanciyar hankali na tsarin jiko tare da taro na 0.1-1 IU ta 1 ml na insulin lispro a cikin 5% dextrose ko 0.9% sodium chloride bayani na kwanaki 2 lokacin da aka adana shi a zazzabi a ɗakin.

Don aiwatar da abubuwan infusions, Kwayoyin cuta na Disetronic da Minimed waɗanda aka tsara don insus infusions za'a iya amfani dasu. Yana da mahimmanci a bi umarnin mai ƙira kuma a bi ƙa'idodin asepticism lokacin da ake haɗa tsarin. Kowane kwanaki 2 suna canza tsarin don jiko. Abun da jiko tare da tsohuwar alawar ya tsaya har sai an warware shi. A cikin yanayin ƙarancin yawan glucose a cikin jini, mai haƙuri ya kamata ya nemi likita don la'akari da rage ko dakatar da haɓakar insulin.

Za'a iya saurin tashi cikin haɗarin glucose na jini tare da tsarin da aka makala don jiko ko lalata famfon. Idan ana zargin cin zarafin isar insulin a matsayin dalilin karuwar taro a cikin glucose, mai haƙuri ya kamata ya bi umarnin mai ƙira kuma ya sanar da likita (idan ya cancanta).

Humalog lokacin amfani da famfo ba za'a iya haɗe shi da sauran insulins ba.

Alkalami na insulin QuickPen ya ƙunshi 3 ml na miyagun ƙwayoyi tare da aiki na 100 IU a cikin 1 ml. Ana iya gudanar da rukunin insulin 1-60 na kowane allura. Za'a iya saita kashi tare da daidaituwa na ɗaya. Idan an kafa sassan da yawa, ana iya gyara kashi ba tare da asarar insulin ba.

Ya kamata mai haƙuri ɗaya ya yi amfani da shi, ya kamata a yi amfani da sabon allura don kowane allura. Kar a yi amfani da allurar in wani ɓangaren sassan sa ya lalace ko ya karye. Mai haƙuri yakamata a ɗauka allura mai mahimmanci koda na asara ko lalacewa.

Marasa lafiya marasa rauni da hangen nesa ko asarar hangen nesa ba a ba da shawarar yin amfani da allurar ba tare da taimakon mutanen da suke gani sosai don horar da su ba.

Kafin kowane allura, yana da mahimmanci a tabbatar cewa ranar karewa da aka nuna akan lakabin bai ƙare ba kuma cewa madaidaicin nau'in insulin yana cikin allurar. A wannan batun, ba da shawarar cire alamar daga ciki ba.

Launin launi na maɓallin saurin saurin maɓallin sikirin da ke cikin QuickPen yana launin toka, yana dacewa da launi na tsiri akan tambarin sa da nau'in insulin da ake amfani dashi.

Kafin yin amfani da injector, kana buƙatar tabbatar cewa allura ta haɗu da ita. Bayan amfani, an cire allurar kuma an zubar dashi. Ba za a iya ajiye alkairin sirinji tare da allura da aka haɗe da shi ba, saboda wannan na iya haifar da kumburin iska ya tashi a cikin ƙwayar magunguna.

Lokacin da za a ƙera adadin ƙwayar magani wanda ya wuce raka'a 60, ana yin allura biyu.

Don bincika ragowar insulin a cikin kabad ɗin, kuna buƙatar nuna allurar tare da ƙarshen allura sama da ganin adadin raka'a insulin akan sikelin da za'a riƙe katako mai ɗaukar hoto.Ba'a yi amfani da wannan alamar don saita kashi ba.

Don cire hula daga allurar, kana buƙatar jan shi. Idan wata matsala ta taso, a hankali juya maɓallin agogo a agogo da kuma agogo, sannan a ja.

Kowane lokaci kafin allura, suna bincika abincin insulin, tunda ba tare da shi ba zaku iya samun insulin kadan ko mai yawa. Don bincika, cire maɗaurin murfin ciki da na ciki, ta juyawa maɓallin kashi, an saita raka'a 2, an jera allurar zuwa sama kuma ta buga mai riƙe da katako don duk iska ta tattara a cikin ɓangaren na sama. Sannan danna maɓallin kashi har sai ya tsaya kuma lambar 0 ta bayyana a cikin taga alamar kashi. Riƙe maɓallin a cikin wurin da aka sake, a hankali ƙidaya zuwa 5, a wannan lokacin wani ɓoɓin insulin yakamata ya bayyana a ƙarshen allura. Idan kwararar insulin bai bayyana ba, ana maye gurbin allura da sabon kuma ana yin aikin sake.

Gudanar da magunguna

• Cire kwatangwalo daga alkalami na syringe
• tare da swab moistened tare da barasa, shafa diski na roba a ƙarshen abin riƙe da katako,
• saka allura a cikin hula kai tsaye a jikin allurar kuma ka goge shi har sai ya kasance gaba ɗaya.
• ta juyawa maɓallin kashi, an saita adadin raka'a,
• Cire hula daga allura kuma sanya shi a karkashin fata,
• tare da yatsa, danna maɓallin kashi har sai ya daina gaba ɗaya. Don shigar da cikakken kashi, riƙe maɓallin kuma sannu a hankali ƙidaya zuwa 5,
• an cire allura daga karkashin fata,
• duba alamar maganin - idan yana da lamba 0 a kansa, an shigar da kashi ɗin gabaɗaya,
• a hankali sanya murfin waje a allura kuma cire shi daga allurar, sannan a jefa shi,
• saka hula a aljihun syringe.

Idan mai haƙuri ya yi shakkar cewa ya ba da cikakkiyar magani, ba za a sake bayar da ƙarin magani ba.

Side effects

• mafi yawan lokuta: hypoglycemia (a lokuta masu rauni, yana iya bauta wa ci gaban haila, a lokuta na musamman - mutuwa),
• mai yiwuwa: lipodystrophy, halayen rashin lafiyan gida - kumburi, redness ko itching a wurin allurar,
• da wuya: halayen halayen rashin lafiyan jiki - haɓaka mai yawa, yawan zafin jiki, tachycardia, hauhawar jini, gazawar numfashi, zazzabi, angioedema, urticaria, itching cikin jiki baki ɗaya.

Umarni na musamman

Canja wurin mara lafiya zuwa wani suna na daban ko nau'in insulin ana aiwatar dashi karkashin kulawar likita. Idan kun canza hanyar samarwa, nau'in, nau'in, alama da / ko aiki, za'a iya buƙatar daidaita sashi.

Kwayar cutar cututtukan da ke nuna ci gaban hypoglycemia na iya zama ƙasa da ma'ana tare da kulawa mai zurfi tare da insulin, kasancewar dogon lokaci na ciwon sukari mellitus, cututtukan da tsarin juyayi na cutar kanjamau, da jiyya na lokaci daya tare da kwayoyi, misali beta-blockers.

Alamar farkon cutar hypoglycemia a cikin marasa lafiya tare da halayen hypoglycemic bayan sauyawa daga insulin dabba da aka samo zuwa insulin mutum na iya zama mai rauni mai rauni ko bambanta da waɗanda suke da insulin da suka gabata yayin maganin.

A cikin yanayin rashin daidaituwa na rashin daidaituwa ko amsawar hypoglycemic, ci gaban asarar sani, coma, ko kuma farkon mutuwa yana yiwuwa. Yin amfani da miyagun ƙwayoyi a cikin isasshen allurai ko dakatar da jiyya, musamman ga nau'in ciwon sukari na mellitus, na iya haifar da haɓakar cututtukan fata da ketoacidosis masu ciwon sukari, waɗanda ke haifar da barazanar rayuwar mai haƙuri.

A ƙarancin koda da na hepatic, zai iya rage buƙatar insulin, wanda ke da alaƙa tare da rage yawan aiki na insulin da tsarin gluconeogenesis. A cikin lalacewar hanta na hanta (saboda karuwar juriya na insulin), damuwa na damuwa, cututtukan cututtuka, haɓaka yawan adadin carbohydrates a cikin abinci, buƙatar insulin na iya ƙaruwa.

A yanayin canje-canje a cikin abincin da aka saba da ƙwarewar aiki, ana buƙatar daidaita sashi na miyagun ƙwayoyi. Lokacin yin motsa jiki na jiki kai tsaye bayan cin abinci, haɓakar haɗarin haɓakar haɓakawa zai yiwu. Sakamakon magunguna na analogues ana amfani da insulin na insulin mutum, yawan jini na iya haɓaka a baya bayan allura fiye da lokacin amfani da insulin ɗan adam mai narkewa.

Lokacin da ake tsara shirin insulin tare da taro na 40 IU a cikin 1 ml a cikin murfin, ba shi yiwuwa a kuɓutar da insulin daga cikin kicin tare da yawan insulin na 100 IU a cikin 1 ml ta amfani da sirinji don gudanar da insulin tare da taro 40 IU a cikin 1 ml.

Lokaci guda tare da shirye-shiryen insulin tare da kwayoyi na rukunin thiazolidinedione yana ƙara haɗarin haɓakar edema da rauni na zuciya, musamman a kan tushen cututtukan cututtukan zuciya da kuma gaban abubuwan haɗari don rauni na zuciya.

Marasa lafiya yayin aikin jiyya yakamata suyi hankali lokacin tuki motoci da gudanar da ayyukan haɗari waɗanda ke buƙatar ƙara kulawa da saurin halayen psychomotor.

Hulɗa da ƙwayoyi

Sakamakon magunguna / abubuwa akan lyspro insulin a hade magani:

• abubuwan da ke faruwa na phenothiazine, nicotinic acid, lithium carbonate, isoniazid, diazoxide, chlorprotixene, thiazide diuretics, antattara maganin tricyclic, beta-2-adrenergic agonists (terbutaline, salbutamol, ritodrin, da sauransu), glandonjin-kansa tsananin tsananin hypoglycemic sakamako,
• angiotensin II receptor antagonists, octreotide, angiotensin-juyar da enzyme inhibitors (enapril, captopril), wasu magungunan antidepressants (monoamine oxidase inhibitors), maganin rigfanilamide, salicylates (acetylsalicylic acid, da sauransu, phenolic kwayoyi, tetragenurolincgg hycg, hypog hycgg ethanol da ethanol-kwayoyi masu dauke da kwayoyi, beta-blockers: ƙara yawan tasirin tasirin tasirinsa.

Ba a hade insulin Lyspro tare da insulin dabbobi ba.

Kafin shan wasu kwayoyi, yana da muhimmanci a nemi likita. A kan shawarwarinsa, ana iya amfani da miyagun ƙwayoyi a hade tare da insulin ɗan adam mai amfani da tsayi ko tare da nau'ikan nau'in sulfonylureas.

Misalin Humalog sune Iletin I na yau da kullun, Iletin II na yau da kullun, Inutral SPP, Inutral HM, Farmasulin.

Sharuɗɗan da yanayin ajiya

Adana a 2-8 ° C a cikin firiji, a cikin sirinji / kwandon shara - har zuwa 30 ° C na tsawon makonni 4. Ayi nesa da isar yara.

Rayuwar shelf shine shekaru 3.

Sharuɗɗan hutu na kantin

An sake shi ta hanyar takardar sayan magani.

An sami kuskure a cikin rubutun? Zaɓi shi kuma latsa Ctrl + Shigar.

Duk da cewa masana kimiyyar sun sami nasarar maimaita kwayar insulin, wanda aka samar a jikin mutum, aikin kwayar halittar har yanzu ya zama a hankali ba saboda lokacin da ake bukata ba don shiga cikin jini. Magunguna na farko na inganta aikin shine Humalog insulin. Ya fara aiki tuni mintina 15 bayan allura, don haka sukari daga jini aka canza shi zuwa kyallen takarda a kan kari, har ma hyperglycemia na ɗan gajeren lokaci bai faruwa.

Yana da mahimmanci a sani! Takaitaccen labari wanda masana ilimin kimiyar lissafi suka shawarce su Ci gaba da Ciwon sukari! Abin kawai ya zama dole a kowace rana.

Idan aka kwatanta da insulins na mutum da aka kirkiro a baya, Humalog yana nuna kyakkyawan sakamako: a cikin marassa lafiya, ana rage canzawar yau da kullun cikin kashi 22%, glycemic fihirisa yana inganta, musamman da rana, kuma da alama rashin jinkiri na raguwar hauhawar jini ya ragu. Sakamakon azumin, amma tsayayyen aiki, ana ƙara amfani da wannan insulin a cikin ciwon sukari.

Bruef umarnin

Umarni game da amfani da insulin Humalog abu ne mai cike da ƙima, kuma sassan da suke bayyana illolin sakamako da kwatance don amfani da sakin layi sama da ɗaya. Bayani mai tsawo da ke rakiyar wasu magunguna ana samun su ta hanyar marasa lafiya a matsayin gargaɗi game da haɗarin shan su. A zahiri, komai kishi ne daidai: babban umarni, - shaidar da yawa gwaji cewa magani samu nasarar tsayayya.

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

Cutar sankarau shine sanadin kusan kashi tamanin cikin ɗari na duka raunin da aka yanke. Mutane 7 daga 10 ne ke mutuwa sakamakon kamuwa da jijiyoyin zuciya da kwakwalwa. A kusan dukkanin lokuta, dalilin wannan mummunan ƙarshen shine guda - sukari na jini.

Sugar zai iya kuma ya kamata a rushe, in ba haka ba komai. Amma wannan ba ya warkar da cutar da kanta, amma kawai tana taimakawa wajen yaƙar bincike, kuma ba dalilin cutar ba.

Kadai magani wanda aka bayar da shawarar hukuma don magance cututtukan cututtukan fata kuma ana amfani da shi ta hanyar endocrinologists a cikin aikin su shine wannan.

Tasirin maganin, wanda aka lasafta bisa ga daidaitaccen hanyar (adadin marasa lafiyar da suka murmure zuwa jimlar yawan marasa lafiya a cikin rukuni na mutanen 100 waɗanda suka sami kulawa) sun kasance:

• Normalization na sukari - 95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya - 90%
• Rabu da cutar hawan jini - 92%
• Thearfafa rana, inganta bacci da dare - 97%

Masana'antu ba kungiyar kasuwanci ba ce kuma an tallafa musu da tallafin jihar. Saboda haka, yanzu kowane mazaunin yana da damar.

An amince da Humalogue don amfani da shi sama da shekaru 20 da suka gabata, kuma yanzu ba shi da haɗari a ce wannan insulin ɗin yana da lafiya a gwargwado daidai. An yarda dashi don amfani da tsofaffi da yara, za'a iya amfani dashi a duk halayen, tare da raɗaɗin rashin haila: nau'in 1 da nau'in ciwon sukari na 2, tiyata.

Janar bayani game da Humalogue:

Daga cikin sakamako masu illa, cututtukan cututtukan zuciya da cututtukan ƙwayar cuta ana lura dasu galibi (1-10% na masu ciwon sukari). Kasa da 1% na marasa lafiya suna haɓakar lipodystrophy a wurin allurar. Mitar wasu halayen masu rauni ba su wuce 0.1% ba.

Abu mafi mahimmanci game da Humalog

A gida, ana gudanar da Humalog ta hanyar amfani da maɓallin sirinji ko. Idan za a kawar da cututtukan hawan jini, za a iya samun damar gudanar da maganin a cikin asibitin. A wannan yanayin, sarrafa sukari akai-akai wajibi ne don kauce wa yawan zubar da ruwa.

Abubuwan da ke aiki na miyagun ƙwayoyi shine insulin lispro. Ya bambanta da hormone mutum a cikin tsari na amino acid a cikin kwayoyin. Irin wannan canjin baya hana masu karɓar tantanin halitta tantance kwayoyin halittar, don haka suna iya sanya sukari cikin kansu cikin sauƙi. Humalogue ta ƙunshi kawai monomers na insulin - guda, kwayoyin da ba a haɗa su ba. Saboda wannan, ana shan shi da sauri kuma a ko'ina, yana fara rage sukari da sauri fiye da insulin al'ada.

Humalog magani ne da ya fi guntu aiki, misali, ko. Dangane da rarrabuwa, ana nufin insulin analogues tare da aikin ultrashort. An fara aikinsa cikin sauri, game da mintina 15, don haka masu ciwon sukari ba dole su jira har sai miyagun ƙwayoyi zasu yi aiki ba, amma zaku iya shirya abinci nan da nan bayan allura. Godiya ga irin wannan ɗan gajeriyar hanya, ya zama mafi sauƙi ga shirya abinci, kuma haɗarin manta abinci bayan allura ya ragu sosai.

Don ingantaccen iko na glycemic, jami'ai masu saurin aiki yakamata a haɗe su da amfani na wajibi. Iyakar abin da ya keɓance shine amfani da famfo na insulin akan aikin mai gudana.

Yankan zaɓi

Humalog sashi ya dogara da dalilai da yawa kuma an ƙaddara daban-daban ga kowane masu ciwon sukari. Yin amfani da tsari na yau da kullun ba da shawarar ba, saboda suna ƙaruwa da diyyar ciwon sukari. Idan mara lafiya ya manne da karancin abincin carbohydrate, kashi na Humalog na iya zama kasa da tsarin gudanarwa na yau da kullun. A wannan yanayin, ana bada shawara don amfani da insulin mai rauni mai rauni.

Ultrashort hormone yana ba da tasiri sosai. Lokacin canzawa zuwa Humalog, ana ƙididdige ƙwayar farkonsa azaman 40% na ɗan gajeren insulin da aka yi amfani dashi a baya. Dangane da sakamakon glycemia, an daidaita sashi. Matsakaicin buƙata don shirye-shiryen kowane yanki burodi shine raka'a 1-1.5.

Tsarin allura

Kalmar humalogue ce kafin kowane abinci, akalla sau uku a rana . Game da sukari mai yawa, ana ba da izinin poplings tsakanin manyan injections. Umarni don amfani yana bada shawarar yin lissafin adadin insulin da ake buƙata dangane da carbohydrates da aka shirya don abinci na gaba. Kimanin mintina 15 ya kamata ya wuce daga allura zuwa abinci.

Dangane da sake dubawa, wannan lokacin ba shi da yawa, musamman da rana, lokacin jure insulin yana ƙasa. Yawan shaye shaye ne na mutum, ana iya yin amfani da shi ta amfani da maimaita matakan glucose na jini kai tsaye bayan allura. Idan an lura da yanayin rage sukari da sauri fiye da umarnin, umarnin lokacin da abinci ya kamata ya ragu.

Humalog shine ɗayan magunguna mafi sauri, saboda haka yana da dacewa don amfani dashi azaman taimakon gaggawa don ciwon sukari idan mai haƙuri yana cikin haɗari.

Lokacin aiki (gajere ko tsawo)

An lura da girman insulin ultrashort a cikin mintuna 60 bayan gudanarwarsa. Tsawan lokacin da ya dogara da sashi, mafi girma shi ne, tsawon lokacin da yake haifar da rage sukari, a matsakaici - kimanin awa 4.

Humalog mix 25

Don kimantawa daidai da tasirin Humalog, dole ne a auna glucose bayan wannan lokacin, yawanci ana yin wannan kafin abinci na gaba. Ana buƙatar ma'aunin farko idan ana zargin hypoglycemia.

Likita na Kimiyyar Kimiyya, Shugaban Cibiyar Nazarin Diabetology - Tatyana Yakovleva

Na yi shekaru da yawa ina nazarin ciwon sukari. Yana da ban tsoro yayin da mutane da yawa suka mutu, har ma da yawa suna zama masu rauni saboda cutar sankara.

Na yi hanzarin ba da labari mai daɗi - Cibiyar Binciken Endocrinological na Kwalejin Kimiyya ta Rasha ta sami nasarar inganta maganin da ke warkar da ciwon sukari gaba daya. A yanzu, ingancin wannan magani yana gab da kashi 98%.

Wani labari mai dadi: Ma'aikatar Kiwon Lafiya ta yi tallafi wanda zai rama babban farashin magunguna. A Rasha, masu ciwon sukari har zuwa 2 ga Maris samun shi - Don kawai 147 rubles!

Shortarancin gajeren lokacin Humalog ba matsala bane, amma fa'idodin maganin. Godiya gareshi, marasa lafiya da ke dauke da cutar sankarar mellitus ba su da yiwuwar fuskantar hauhawar jini, musamman da daddare.

Humalog Mix

Baya ga Humalog, kamfanin harhada magunguna Lilly Faransa yana samar da Humalog Mix. Cakuda ne na lyspro insulin da kuma sulfate protamine. Godiya ga wannan haɗin, lokacin farawa na hormone yana kasancewa cikin sauri, kuma tsawon lokacin aiki yana ƙaruwa sosai.

Humalog Mix yana samuwa a cikin taro biyu:

Amfanin kawai irin waɗannan kwayoyi shine hanya mafi sauƙi na allurar rigakafi. Sakamakon ciwon sukari mellitus tare da yin amfani da shi ya fi muni da lokacin yin amfani da insulin na asibiti da kuma amfani da Humalog na yau da kullun, sabili da haka, don Yara Humalog Mix ba a amfani da su .

An wajabta wannan insulin:

1. Masu ciwon sukari waɗanda ba sa iya yin lissafin ɗayan kai-tsaye ko kuma yin allura, alal misali, saboda hangen nesa mara kyau, gurguwa ko rawar jiki.
2. Marasa lafiya tare da rashin hankali.
3. Tsofaffi marasa lafiya da ke da yawan rikice-rikice na ciwon sukari da ƙarancin hangen nesa idan ba su son yin karatu.
4. Masu ciwon sukari masu fama da cuta ta 2, idan har ana samar da nasu hormone.

Kula da ciwon sukari tare da Humalog Mix yana buƙatar tsayayyen tsarin abinci, kayan snack a tsakanin abinci. An ba shi damar cin abinci har zuwa 3 XE don karin kumallo, har zuwa 4 XE don abincin rana da abincin dare, kusan 2 XE don abincin dare, da 4 XE kafin lokacin bacci.

Analogs na Humalog

Lyspro insulin a matsayin abu mai aiki yana ƙunshe ne kawai a cikin Humalog na asali. Magungunan kusa-da-kullun sune (bisa ga aspart) da (glulisin). Wadannan kayan aikin suma yanada matattakala, dan haka bashi da mahimmanci wanda zaba. Dukkansu suna da haƙuri da kyau kuma suna samar da raguwa cikin sauri a cikin sukari. A matsayinka na doka, ana ba da fifiko ga maganin, wanda za'a iya samun kyauta a asibiti.

Sauyawa daga Humalog zuwa misalinsa ana iya zama dole idan akwai rashin lafiyan halayen. Idan mai ciwon sukari ya manne da tsarin karancin abinci mai karafa, ko kuma yawanci yana da matsalar rashin haihuwa, zai fi dacewa mutum yayi amfani da mutum maimakon insulin ultrashort.

Tabbatar koya! Shin kuna tsammanin kulawa da kwayoyin hana daukar ciki da insulin shine hanya daya tilo da za'a kula da sukari? Ba gaskiya bane! Kuna iya tabbatar da wannan da kanku ta hanyar fara amfani da shi.

Kwayar halittar cikin jikin ɗan adam ta kasance.
Shiri: HUMALOG®
Aiki mai guba na miyagun ƙwayoyi: insulin lyspro
Lullukin ATX: A10AB04
KFG: insulin ɗan adam-gajere
Lambar yin rijista: P A'a 015490/01
Ranar rajista: 02.02.04
Mai mallaka reg. acc.: LILLY FRANCE S.A.S.

Maganin maganin allura abu ne mara kyau, mara launi.

1 ml
insulin lispro *
100 IU

Mahalarta: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, ruwa d / da, hydrochloric acid acid na 10% da sodium hydroxide bayani na 10% (don ƙirƙirar matakin pH da ake buƙata).

3 ml - katako (5) - blister (1) - fakitoci na kwali.

* Sunan kasa-da-kasa na mallakar ta wanda WHO ta ba da shawarar, a cikin Tarayyar Rasha, an karɓi fassarar sunan ƙasa - insulin lispro.

Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Humalog na aikin magunguna

Kwayar halittar cikin jikin ɗan adam ta kasance. Ya bambanta da na ƙarshen gaba a cikin jerin amino acid a cikin matsayi na 28 da 29 na sarkar insulin B.

Babban tasirin maganin shine ƙayyadadden tsarin glucose metabolism. Bugu da kari, yana da tasirin anabolic. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

A cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2, lokacin amfani da insulin lyspro, ƙwaƙwalwar ƙwayar cuta wanda ke faruwa bayan cin abincin ya fi raguwa idan aka kwatanta da insulin ɗan adam mai narkewa. Ga marasa lafiya da ke karbar gajeriyar motsa jiki da na basal, ya zama dole a zabi kashi biyu na insulins don samun ingantaccen matakan glucose na jini a duk tsawon rana.

Kamar yadda yake tare da duk shirye-shiryen insulin, tsawon lokacin aikin lyspro insulin na iya bambanta a cikin marassa lafiya daban-daban ko a lokuta daban-daban a cikin mai haƙuri ɗaya kuma ya dogara da kashi, wurin allura, samarda jini, zazzabi jiki da aikin jiki.

Halayen magunguna na insulin lyspro a cikin yara da matasa sunyi kama da waɗanda aka lura da su a cikin manya.

A cikin marasa lafiya da masu ciwon sukari na nau'in 2 ke karɓar iyakar abubuwan da suka samo asali na maganin sulfonylurea, ƙari na insulin lyspro yana haifar da raguwa mai yawa a cikin haemoglobin glycosylated.

Kulawar insulin Lyspro a cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2 yana haɗuwa tare da raguwa a cikin adadin abubuwan da ke haifar da cutar rashin ƙwaƙwalwar ƙwaƙwalwa ta nocturnal.

Amsar glucodynamic ga isulin lispro bai dogara da aikin kodan ko hanta ba.

An nuna insulin Lyspro yayi daidai da insulin na mutum, amma aikinta yana faruwa da sauri kuma yana tsawan lokaci.

Lyspro insulin yana nunawa ta hanyar farawa da sauri (game da mintina 15), kamar yadda Yana da babban adadin sha, kuma wannan yana ba ka damar shigar da shi kai tsaye kafin abinci (mintuna 0-15 kafin abinci), ya bambanta da insulin gajere na al'ada (minti 30-45 kafin abinci). Lyspro insulin yana da ɗan gajeren lokacin aiki (2 zuwa 5 hours) idan aka kwatanta da insulin ɗan adam na al'ada.

Pharmacokinetics na miyagun ƙwayoyi.

Tsotsa da rarrabawa

Bayan sc gwamnatin, insulin Lyspro yana da sauri kuma ya kai Cmax a cikin jini na jini bayan mintuna 30-70. Vd na insulin lyspro da sauran insulin na mutum suna daidai kuma suna cikin kewayon 0.26-0.36 l / kg.

Tare da gudanarwar ins na T1 / 2 na insulin, lyspro yana kusan awa 1. Marasa lafiya tare da rashin haihuwa da kuma hepatic insufficiency suna riƙe da babban adadin yawan ƙwayar lyspro idan aka kwatanta da insulin ɗan adam na al'ada.

Alamu don amfani:

Ciwon sukari a cikin manya da yara, suna buƙatar insulin far don kiyaye matakan glucose na yau da kullun.

Sashi da hanyar gudanar da magani.

Likita ya kayyade maganin daban-daban, gwargwadon bukatun mai haƙuri. Ana iya gudanar da Humalog jim kaɗan kafin abinci, idan ya cancanta - nan da nan bayan cin abinci.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin.

Ana gudanar da Humalog sc a cikin hanyar injections ko kuma a cikin hanyar kara jiko sc jiko ta amfani da famfon.Idan ya cancanta (ketoacidosis, m rashin lafiya, lokacin tsakanin aiki ko bayan aikin) Za a iya shigar da Humalog cikin / in.

Ya kamata a gudanar da SC zuwa kafada, cinya, gindi ko ciki. Yakamata a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata. Lokacin da s / zuwa gabatarwar miyagun ƙwayoyi Humalog, dole ne a kula don hana shigar da miyagun ƙwayoyi cikin jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba. Yakamata a horar da mai haƙuri cikin madaidaiciyar dabarar.

Dokoki don gudanar da maganin Humalog

Shiri don gabatarwa

Maganin maganin Humalog yakamata ya zama amintacce kuma mara launi. Baƙin amfani da gajimare, ko tauri ko ta ɗanɗano launi, ko kuma idan an gano daskararru na gani a ciki, to baza ayi amfani dashi ba.

Lokacin shigar da katun a cikin alkairin sirinji (alkalami-injector), riƙe allura da kuma yin allurar insulin, ya wajaba a bi umarnin mai ƙira da ke haɗe da kowane alkalami mai sirinji.

2. Zaɓi wani wuri don allura.

3. Alluba don magance fata a wurin allurar.

4. Cire hula daga allura.

5. Gyara fata ta hanyar shimfida shi ko ta hanyar adana babban falo. Saka allura daidai da umarnin don amfani da alkairin sirinji.

6. Latsa maɓallin.

7. Cire allura kuma a hankali matsi da allurar site na da yawa saika. Kar a shafa wurin allurar.

8. Yin amfani da kabarin allura, kwance allurar kuma ka lalata shi.

9. Wajibi ne a sauya wuraren da ake yin allurar don kada a yi amfani da wurin iri ɗaya ba sau ɗaya ba sau 1 a kowane wata.

Gudanar da insulin na insulin

Ya kamata a aiwatar da allurar rigakafin Humalog daidai da yadda ake yin allurar asibiti na yau da kullun, alal misali, gudanarwar allurar cikin gida ko yin amfani da tsarin jiko. Haka kuma, galibi ya zama dole a sarrafa matakin glucose a cikin jini.

Tsarin jiko tare da tarawa daga 0.1 IU / ml zuwa 1.0 IU / ml insulin lispro a cikin 0.9% sodium chloride bayani ko 5% dextrose bayani shine barga a zazzabi a daki na awanni 48.

P / C insulin jiko ta amfani da famfon insulin

Don jiko na ƙwayar Humalog, Ana iya amfani da famfunan rage ƙwayar cuta da ƙananan ƙwayoyin cuta don jiko na insulin. Dole ne a bi umarnin mai zuwa tare da famfo. Ana canza tsarin jiko a kowane sa'o'i 48. Lokacin da aka haɗa tsarin jiko, ana kiyaye ka'idojin aseptic. Idan aka sami labarin ainahin yanayin da ake ciki, jikan ya tsaya har sai abin da ya faru ya warware. Idan akwai matakan glucose masu yawa a cikin jini sau da yawa, to lallai ne ku sanar da likitanka game da wannan kuma kuyi la'akari da rage ko dakatar da haɓakar insulin. Rashin ƙwayar famfo ko tarko a cikin tsarin jiko na iya haifar da hauhawar hauhawar matakan glucose. Idan ana zargin cin zarafin insulin, dole ne a bi umarnin kuma, idan ya cancanta, sanar da likita. Lokacin amfani da famfo, ƙwayar Humalog bazai hade da sauran insulins ba.

Tasirin sakamako Humalog:

Sakamakon sakamako wanda ya danganta da babban sakamakon maganin: hypoglycemia. Mai tsananin rashin ƙarfi na iya haifar da asarar hankali (ƙin jinin haila) kuma, a lokuta na musamman, ga mutuwa.

Allergic halayen: halayen rashin lafiyan gida na yiwuwa - redness, kumburi ko itching a wurin allura (yawanci yakan ɓace cikin daysan kwanaki ko makonni), halayen rashin lafiyan ƙabilanci (na faruwa ba sau da yawa, amma sun fi tsanani) - naƙasa ta haɓaka, amaƙar fata, amai, amai, zazzaɓi, gajere na numfashi, rage karfin jini, tachycardia, haɓaka mai ɗaci. Mummunan lokuta na halayen rashin lafiyan halayen na iya zama barazanar rayuwa.

Sauran: lipodystrophy a wurin allurar.

Contraindications wa miyagun ƙwayoyi:

Hypersensitivity ga abubuwan da ke cikin miyagun ƙwayoyi.

Yi amfani da lokacin daukar ciki da lactation.

Har zuwa yau, ba a gano tasirin insulin Lyspro akan ciki ko lafiyar ɗan tayi / jariri ba. Babu wani binciken da ya dace da karatun da akayi.

Manufar insulin jiyya a lokacin daukar ciki shine don kula da isasshen iko na glucose matakan a cikin marasa lafiya da insulin-dogara da sukari mellitus ko tare da ciwon sukari na gestational. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki. A lokacin daukar ciki, marasa lafiya da ciwon sukari suna buƙatar saka idanu sosai game da matakan glucose na jini, kazalika da saka idanu na asibiti gaba ɗaya.

A cikin marasa lafiya da ciwon sukari mellitus yayin shayarwa, ana buƙatar daidaita sashin insulin da / ko rage cin abinci.

Umarnin musamman don amfani da Humalog.

Canja wurin mara lafiya zuwa wani nau'in ko samfurin insulin yakamata a gudanar dashi karkashin kulawar likita. Canje-canje a cikin aiki, alama (masana'anta), nau'in (misali, Na yau da kullun, NPH, Tape), nau'in (dabba, ɗan adam, analog na insulin mutum) da / ko hanyar samarwa (insulin maimaita insulin ko insulin asalin dabbobi) yana iya buƙatar kashi canje-canje.

Yanayin da alamun farkon faɗakarwar cututtukan cututtukan jini na iya zama marasa ma'ana kuma ƙasa da ƙima sun haɗa da ci gaba da wanzuwar ciwon sukari, maganin insulin mai narkewa, cututtukan ƙwayar cuta a cikin cututtukan sukari, ko magunguna, kamar beta-blockers.

A cikin marasa lafiya waɗanda ke fama da hypoglycemic bayan canjawa daga insulin dabbobi da aka samo zuwa insulin na mutum, alamun farko na hypoglycemia na iya zama ƙarancin bayyanawa ko bambanta da waɗanda suka ɗanɗana da insulin da suka gabata. Rashin daidaituwa na hypoglycemic ko hyperglycemic halayen na iya haifar da asarar sani, coma, ko mutuwa.

Inarancin allurai ko dakatarwar magani, musamman tare da insulin-insulin-da ke fama da cutar sankara, na iya haifar da hyperglycemia da ketoacidosis mai ciwon sukari, yanayin da ke haifar da barazanar rayuwa ga mai haƙuri.

Bukatar insulin na iya raguwa a cikin marasa lafiya tare da gazawar koda, haka kuma a cikin marasa lafiya da gazawar hanta a sakamakon raguwa cikin ayyukan gluconeogenesis da metabolism metabolism. Koyaya, a cikin marasa lafiya tare da gazawar hanta na rashin ƙarfi, karuwar juriya na insulin na iya haifar da karuwa a cikin insulin.

Bukatar insulin na iya ƙaruwa tare da cututtuka masu raɗaɗi, damuwa na damuwa, tare da karuwa da adadin carbohydrates a cikin abincin.

Hakanan ana iya buƙatar daidaita sikelin idan aikin mai haƙuri ya karu ko kuma abincin da yake ci yana canzawa. Yi motsa jiki nan da nan bayan cin abinci yana kara haɗarin hawan jini. Sakamakon magunguna na insulin analogues na aiki da sauri shine idan hypoglycemia ya haɓaka, to zai iya haɓaka bayan allura a baya fiye da lokacin allurar ɗan adam mai narkewa.

Yakamata a gargadi mara lafiya cewa idan likita ya tsara shirin insulin tare da maida hankali 40 IU / ml a cikin murfin, to kada a dauki insulin daga kicin din tare da yawan insulin na 100 IU / ml tare da sirinji don allurar insulin tare da tattara 40 IU / ml.

Idan ya zama dole a dauki wasu kwayoyi a lokaci guda kamar Humalog, mai haƙuri ya kamata ya nemi likita.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Tare da hypoglycemia ko hyperglycemia da ke da alaƙa da ƙarancin allurar allurar rigakafi, tauye ikon yin hankali da saurin halayen psychomotor mai yiwuwa. Wannan na iya zama haɗari ga haɗari mai haɗari (gami da tuki motoci ko aiki tare da kayan aiki).

Dole ne marasa lafiya su yi hankali don guje wa hypolycemia yayin tuki. Wannan yana da mahimmanci musamman ga marasa lafiya waɗanda ke da raunin ji ko rashin jin alamun bayyanar alamun bayyanar cutar hypoglycemia, ko kuma a cikin abin da cututtukan cututtukan jini suka zama ruwan dare. A cikin waɗannan yanayin, wajibi ne don tantance yiwuwar tuƙi. Marasa lafiya tare da ciwon sukari na iya kawar da tsinkayen kai a jiki ta hanyar shan gulukos ko abinci mai yawa a cikin carbohydrates (ana ba da shawarar cewa ko da yaushe kuna da 20 g of glucose tare da ku). Mai haƙuri ya kamata ya sanar da likitan halartan game da ƙaddamarwar cututtukan jini.

Adadin yawa na miyagun ƙwayoyi:

Bayyanar cututtuka: hawan jini, tare da waɗannan alamomi masu zuwa: ƙarancin jiki, ƙara yawan zagi, tachycardia, ciwon kai, amai, rikicewa.

Jiyya: sauƙin yanayin hypoglycemia yawanci ana tsayar da shi ta hanyar shigar glucose ko wasu sukari, ko samfuran da ke ɗauke da sukari.

Ana iya aiwatar da gyaran hypoglycemia mai zafi a matsakaici tare da taimakon a / m ko s / c na gudanarwar glucagon, biyo baya ta hanyar carbohydrates bayan inganta yanayin haƙuri. Marasa lafiya waɗanda ba su amsa glucagon ana ba su bayani na iv dextrose (glucose) ba.

Idan mai haƙuri yana cikin coma, to ya kamata a gudanar da glucagon a / m ko s / c. Idan babu glucagon ko kuma idan ba a dauki mataki ba game da gudanarwar sa, to ya zama dole a bullo da wani bayani mai narkewa na dextrose (glucose). Nan da nan bayan an sake farkawa, dole ne a bai wa mara lafiya abinci mai-carbohydrate.

Ana iya buƙatar ƙarin cin abincin carbohydrate da saka idanu na haƙuri, kamar yadda sake dawowa daga cututtukan jini zai yiwu.

H hullog hulɗa tare da wasu kwayoyi.

Humalog's hypoglycemic sakamako yana rage ta hanyar hana haihuwa, corticosteroids, shirye-shiryen hodar iblis thyroid, danazol, beta2-adrenergic agonists (gami da rhytodrin, salbutamol, terbutaline), tricyclic antidepressants, thiazide diuretics, chlorprotixenic acid, nikloracin acid, ni abubuwan da aka samo asali na phenothiazine.

Hypoglycemic mataki Humalog karuwa beta-blockers, ethanol da etanolsoderzhaschie kwayoyi, anabolic steroids, fenfluramine, guanethidine, tetracyclines, na baka hypoglycemic jamiái, salicylates (msl, acetylsalicylic acid), sulfonamides, Mao hanawa, ACE hanawa (captopril, enalapril), octreotide, antagonists masu karɓar angioensensin II.

Kada a haɗa Humalog tare da shirye-shiryen insulin dabbobi.

Ana iya amfani da Humalog (a karkashin kulawa na likita) a hade tare da insulin ɗan adam mai amfani da tsayi ko a hade tare da wakilai na maganin hypoglycemic na baki, abubuwan samo asali na sulfonylurea.

Sharuɗɗan sayarwa a cikin magunguna.

Magungunan magani ne.

Sharuɗɗan yanayin ajiya na miyagun ƙwayoyi Humalog.

Lissafi B. Ya kamata a adana magungunan ba tare da isar yara ba, a cikin firiji, a zazzabi na 2 ° zuwa 8 ° C, kada a daskare. Rayuwar shelf shine shekaru 2.

Ya kamata a adana magani a cikin ɗakin zazzabi a 15 ° zuwa 25 ° C, an kiyaye shi daga hasken rana kai tsaye da zafi. Rayuwar shelf - ba fiye da kwanaki 28 ba.

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Humalogue . Yana ba da ra'ayi daga baƙi zuwa rukunin yanar gizon - masu cin wannan magani, da kuma ra'ayoyin kwararrun likitocin game da amfani da Humalog a aikace.Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Analogs na Humalog a gaban wadatattun analogues na tsarin ana amfani dasu. Yi amfani da shi don lura da nau'in 1 da nau'in ciwon sukari na 2 na sukari (wanda ke dogara da insulin-insulin-da kuma cututtukan da ba na insulin-suba) a cikin manya, yara, har ma lokacin daukar ciki da lactation. Abun da magani.

Humalogue - analog na insulin na ɗan adam, ya bambanta da shi ta hanyar jeri na proline da linsine amino acid na raguwa a matsayi na 28 da 29 na sarkar insulin B. Idan aka kwatanta da shirye-shiryen insulin gajere, lyspro insulin ana nuna shi da sauri da kuma ƙarshen tasirin, wanda shine saboda karɓar sha daga ƙwaƙwalwar subcutaneous saboda adana tsarin monomeric na kwayoyin insulin lyspro a cikin maganin. Farawar aiki shine mintina 15 bayan gudanarwar subcutaneous, matsakaicin sakamako shine tsakanin awa 0.5 zuwa awa 2.5, tsawon lokacin aikin shine sa'o'i 3-4.

Humalog Mix shine DNA - sake zama analog na insulin ɗan adam kuma wani cakuda ne wanda aka yi shi wanda ya ƙunshi bayani na insulin lyspro (analog mai aiki da insulin na ɗan adam) da dakatarwar insulin na lyspro pro-matsakaici na ɗan adam.

Babban aikin insulin lyspro shine tsari na metabolism metabolism. Bugu da ƙari, yana da tasirin anabolic da anti-catabolic akan ƙoshin jikin mutane daban-daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

Lyspro insulin + excipients.

Cikakken kamfani da kuma farawar insulin ya dogara da shafin allura (ciki, cinya, gindi), kashi (girman insulin allurar), da kuma tattarawar insulin a cikin shiri. An rarraba shi ba tare da daidaituwa ba a cikin kyallen takarda. Bai ƙetare katangar ƙwarya ba kuma cikin madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya cire shi - 30-80%.

• type 1 ciwon sukari mellitus (insulin-dogara), gami da tare da rashin haƙuri ga sauran shirye-shiryen insulin, tare da hyperglycemia postprandial waɗanda ba za a iya gyara su ta hanyar wasu shirye-shiryen insulin ba, ƙarancin insulin ƙananan insulin (lalacewar insulin na cikin gida),
• nau'in ciwon sukari na 2 na ciwon sukari (wanda ba shi da insulin-insulin) ba: tare da juriya ga wakilai na yawan maganganu na baki, kazalika da shan wahala na sauran shirye-shiryen insulin, hyperglycemia na rashin daidaituwa, yayin aiki, cututtukan da ke shudewa.

Magani don gudanarwar ciki da karkara na sarrafa 100 IU a cikin kwatin 3 ml da aka haɗa cikin allurar QuickPen ko sirinji na alkalami.

Dakatarwa don ƙaddamarwa na 100 IU a cikin kundin 3 ml a cikin kundin QuickPen ko alkalami na alkalami (Humalog Mix 25 da 50).

Sauran nau'ikan sashi, koda Allunan ko kuma kwansonsu, babu su.

Umarnin don amfani da hanyar amfani

An saita sashi daban daban. Ana gudanar da insulin na Lyspro subcutaneously, intramuscularly ko intravenously 5-15 mintuna kafin cin abinci. Singleaya daga cikin kashi shine raka'a 40, an yarda da wuce haddi a cikin lokuta na musamman. Tare da monotherapy, ana gudanar da insulin Lyspro sau 4-6 a rana, a hade tare da shirye-shiryen insulin tsawan lokaci - sau 3 a rana.

Ya kamata a gudanar da miyagun ƙwayoyi a ƙarƙashin ƙasa.

M ciki da miyagun ƙwayoyi Humalog Mix an contraindicated.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin.

Ya kamata a allurar da kashi a cikin kafada, cinya, gindi ko ciki. Yakamata a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata.Lokacin da s / zuwa gabatarwar miyagun ƙwayoyi Humalog, dole ne a kula don hana shigar da miyagun ƙwayoyi cikin jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba.

Lokacin shigar da kundin a cikin injection insulin kuma yana ɗaukar allura kafin gudanarwar insulin, dole ne a kiyaye umarnin mai ƙirar insulin naúrar gudanar da aikin.

Dokoki don gabatarwar miyagun ƙwayoyi Humalog Mix

Shiri don gabatarwa

Nan da nan kafin amfani da shi, yakamata a jujjuya murfin Humalog Mix a cikin tafin hannun ya ninka sau goma kuma ya girgiza, ya juya 180 ° kuma sau goma don sake farfadowa da insulin har sai yayi kama da ruwa mai hade ko madara mai kama da juna. Shake da ƙarfi, kamar yadda wannan na iya haifar da kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi. Don sauƙaƙe hadawa, kundin ya ƙunshi karamin dutsen ado. Bai kamata a yi amfani da miyagun ƙwayoyi ba idan ya ƙunshi flakes bayan haɗuwa.

Yadda ake gudanar da maganin

1. Wanke hannu.
2. Zaɓi wurin yin allura.
3. Bi da fata tare da maganin rigakafi a wurin allurar (tare da allurar kai, daidai da shawarar likita).
4. Cire takalmin kariya daga allura.
5. Gyara fata ta hanyar jan shi ko adon babban falo.
6. Saka allura a ƙarƙashin kuma aiwatar da allurar daidai da umarnin don amfani da alkairin sirinji.
7. Cire allura kuma a hankali matsi wurin allurar don aan seconds. Kar a shafa wurin allurar.
8. Yin amfani da matattarar kariya ta allura, kwance allurar sai ka lalata shi.
9. Saka hula a aljihun syringe.

• hypoglycemia (tsananin hypoglycemia na iya haifar da asarar hankali kuma, a lokuta na musamman, ga mutuwa),
• jan launi, kumburi, ko ƙaiƙayi a wurin allura (yawanci yakan ɓace cikin aan kwanaki ko makonni, a wasu yanayi waɗannan halayen ana iya haifar dasu ta hanyar dalilan da basu da nasaba da insulin, alal misali, haushi na fata ta hanyar allura ko rashin allurar),
• na sarrafa itching
• wahalar numfashi
• karancin numfashi
• raguwa a cikin karfin jini,
• samarin
• ƙara yin gumi
• haɓakar lipodystrophy a wurin allurar.

• hawan jini,
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Haihuwa da lactation

Har zuwa yau, ba a bayyana sakamakon insulin Lyspro akan ciki ba ko kuma yanayin tayin da jariri.

Manufar insulin far a lokacin daukar ciki shine kula da isasshen kulawar glucose. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki.

A cikin marasa lafiya da ciwon sukari mellitus yayin shayarwa, ana buƙatar daidaita sashin insulin da / ko rage cin abinci.

Hanyar gudanarwa da aka yi nufin amfani da shi don amfani da nau'in insulin lyspro ya kamata a kiyaye shi sosai. Lokacin canja wurin marasa lafiya daga shirye-shiryen insulin mai sauri-sauri na asalin dabba zuwa insulin lispro, ana iya buƙatar daidaita sashi. Canja wurin marasa lafiya da suke karɓar insulin a cikin kashi-kashi na yau da kullun da suka wuce raka'a 100 daga nau'in insulin zuwa wani an bada shawarar a kai su asibiti.

Bukatar insulin na iya ƙaruwa yayin cutar, tare da damuwa na ruhi, tare da haɓaka yawan adadin carbohydrates a cikin abinci, yayin ƙarin ƙwayoyi na ƙwayoyi tare da aikin hyperglycemic (hormones thyroid, glucocorticoids, hana maganin hana haihuwa, thiazide diuretics).

Bukatar insulin na iya raguwa tare da renal da / ko gazawar hanta, tare da raguwa a cikin adadin carbohydrates a abinci, tare da ƙara yawan motsa jiki, yayin ƙarin ƙarin magunguna tare da aikin hypoglycemic (inhibitors na MAO, masu hana beta-blockers, sulfonamides).

Ana iya aiwatar da gyaran hypoglycemia a cikin wani yanayi mai mahimmanci ta amfani da i / m da / ko s / c gudanar da glucagon ko iv na glucose.

Tasirin hypoglycemic na Lyspro yana haɓaka ta hanyar MAO inhibitors, masu hana beta-blockers, sulfonamides, acarbose, ethanol (barasa) da ethanol dauke da kwayoyi.

Tasirin hypoglycemic na Lyspro insulin ya rage ta glucocorticosteroids (GCS), hodar iblis, maganin hana haihuwa, thiazide diuretics, diazoxide, antidepressants na tricyclic.

Beta-blockers, clonidine, reserpine na iya rufe alamun bayyanar cututtuka na hypoglycemia.

Analogs na miyagun ƙwayoyi Humalog

Tsarin analogues na mai aiki abu:

• Lyspro insulin
• Humalog Mix 25,
• Humalog Mix 50.

Analogs ta ƙungiyar magunguna (insulins):

• HM Penfill,
• Aikin MS,
• B-Insulin S.Ts. Barcelona Chemie,
• Berlinsulin H 30/70 U-40,
• Berlinsulin H 30/70 alkalami,
• Berlinsulin N Basal-40,
• Berlinsulin N Basal Pen,
• Berlinsulin N Na al'ada U-40,
• Berlinsulin N Al'adala,
• Asarar insulin C,
• Isofan insulin Gasar Cin Kofin Duniya,
• Iletin
• Insulin Tape SPP,
• Insulin c
• Insulin na alade yana tsarkakakken babban ɗanɗani MK,
• Insumanci Comb,
• Ciki na ciki,
• Yakin Duniya na Yankin,
• Combinsulin C
• Mikstard 30 NM Penfill,
• Monosuinsulin MK,
• Monotard
• Pensulin,
• Protafan HM Shawnigan,
• Protafan MS,
• Rinsulin
• UltMard NM,
• Homolong 40,
• Homorap 40,
• Humulin.

Idan babu analogues na miyagun ƙwayoyi don ƙwayar abu mai aiki, zaku iya danna hanyoyin da ke ƙasa zuwa cututtukan da maganin da ya dace ya taimaka daga kuma duba magungunan analogues na maganin warkewa.

Humalog: umarnin don amfani

1 ml ya ƙunshi:

abu mai aiki: insulin lispro 100 IU / ml,

tsofaffi: glycerol (glycerin), zinc oxide, sodium hydrogen phosphate heptahydrate, metacresol, ruwa don allura, hydrochloric acid 10% da sodium hydroxide bayani 10% don kafa pH.

Aikin magunguna

Babban aikin insulin lyspro shine tsari na metabolism metabolism.

Bugu da ƙari, insulins suna da bambancin anabolic da anti-catabolic don kyallen iri daban-daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

An kwatanta insulin Lyspro ta hanyar farawa da sauri (kusan mintuna 15), wanda ke ba da damar sarrafa shi kai tsaye kafin abinci (mintuna 0-15 kafin abinci), sabanin insulin na yau da kullun (minti 30-45 kafin abinci). An bayyana aikin insulin lyspro da sauri, yana da gajarta lokacin aiki (daga 2 zuwa 5 hours) idan aka kwatanta da na al'ada insulin.

Nazarin asibiti wanda aka gudanar a cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2 wanda ya nuna cewa tare da insulin lyspro, hyperglycemia na postprandial yana raguwa sosai idan aka kwatanta da insulin ɗan adam mai narkewa.

Kamar yadda tare da duk shirye-shiryen insulin, tsawon lokacin aikin lyspro insulin na iya bambanta a cikin marassa lafiya daban-daban ko kuma a lokuta daban-daban a cikin mai haƙuri ɗaya kuma ya dogara da kashi, wurin allura, samarda jini, zazzabi jiki da jiki.

An gudanar da gwaje-gwaje na asibiti wanda ya shafi yara (marasa lafiya 61 masu shekaru 2 zuwa 11), kazalika da yara da matasa (marasa lafiya 481 masu shekaru 9 zuwa 19), waɗanda suka kwatanta insulin lispro da insulin ɗan adam.Halayen magunguna na insulin lyspro a cikin yara sun yi kama da waɗanda ke cikin manya.

Lokacin amfani dashi cikin famfon na insulin, mafi ƙarancin raguwa a matakin glycosylated haemoglobin an lura dashi yayin jiyya tare da insulin lispro idan aka kwatanta da magani tare da insulin ɗan adam mai narkewa. A cikin binciken makabarta mai makafi sau biyu, raguwar cutar haemoglobin ta glycosylated bayan makonni 12 na jiyya shine 0.37% a cikin rukunin insulin lispro idan aka kwatanta da 0.03% a cikin rukunin insulin na mutum mai narkewa (p = 0.004).

A cikin marasa lafiya da masu ciwon sukari na nau'in 2 ke karɓar iyakar abubuwan da suka samo asali na maganin sulfonylurea, ƙari na insulin lyspro yana haifar da raguwa mai yawa a cikin matakan gemocosylated. Rage matakan HbAic yakamata a sa zuciya tare da sauran shirye-shiryen insulin, kamar mai narkewa ko NPH.

Nazarin asibiti ya nuna cewa maganin insulin tare da marasa lafiya na lyspro da ke dauke da nau'ikan cututtukan mellitus na 1 da 2 yana haɗuwa da raguwa a cikin adadin abubuwan rashin daidaituwa na rashin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa idan aka kwatanta da insulins na mutum mai narkewa. A cikin wasu nazarin, raguwa a cikin yawan abubuwan rashin daidaituwa na rashin haihuwa sun danganta da karuwa a cikin kwanakin tashin hankali na rana.

Amsar glucodynamic ga insulin lyspro tana da 'yanci daga raunin ko na jijiya. Bambanci a cikin glucodynamics tsakanin insulin lyspro da insulin ɗan adam da aka samu yayin gwajin euglycemic hyperinsulinemic clamp an tallafa a cikin nau'ikan aiki na renal. An nuna insulin Lyspro yayi daidai da insulin na mutum, amma aikinsa yayi sauri kuma yana tsawan ɗan gajeren lokaci.

Pharmacokinetics

A cikin marasa lafiya tare da gazawar koda, mafi yawan adadin ƙwayar lyspro ana kiyaye shi idan aka kwatanta da insulin ɗan adam mai narkewa. A cikin marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na mellitus, bambance-bambancen na pharmacokinetic tsakanin insulin lispro da insulin ɗan adam mai narkewa ana ɗaukar su ta fannoni da yawa na aikin renal, ba tare da la'akari da aikin na koda ba. A cikin marasa lafiya da rashin isasshen hepatic, yawan ƙwayar cuta da cirewa daga cikin insulin lyspro an kiyaye shi idan aka kwatanta da insulin ɗan adam na al'ada.

Alamu don amfani

Kulawa da marasa lafiya da masu ciwon sukari waɗanda ke buƙatar insulin don kula da homeostasis na al'ada na al'ada. Humalog® kuma an nuna shi don farkon maganin cutar sukari.

Contraindications

Hypersensitivity ga insulin lyspro ko kowane ɓangaren magungunan. Hypoglycemia.

Haihuwa da lactation

Bayanai daga ɗimbin yawan amfani da juna biyu ba su bayyana wani sakamako na rashin amfani da insulin Lyspro akan ciki ba ko kuma lafiyar lafiyar tayin / jariri ba.

Makasudin kula da insulin a lokacin daukar ciki shine don kula da isasshen iko a cikin marasa lafiya da ke fama da cutar sukari da ke fama da cutar sukari ko kuma tare da cutar suga ta gestational. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki. A lokacin daukar ciki, marasa lafiya da ciwon sukari suna buƙatar saka idanu sosai game da matakan glucose na jini, kazalika da kulawa na asibiti gaba ɗaya.

Ga marasa lafiya da ke fama da cutar siga, ana iya buƙatar daidaita insulin da / ko abinci a yayin shayarwa.