Yadda ake amfani da Lorista N don ciwon sukari

Lorista ® N - hada magunguna, yana da tasirin gaske.

Losartan. Zaɓin mai karɓar angiotensin II mai antagonist (nau'in AT 1) don gudanar da maganin baka, yanayin rashin furotin. A cikin vivo da a cikin vitro losartan da biocarically carboxy metabolite (EXP-3174) suna toshe duk mahimmancin ilimin halittar jiki na angiotensin II akan masu karɓar AT 1.

Losartan kai tsaye yana haifar da kunnawa ga masu karɓar AT 2 ta hanyar haɓaka matakin angiotensin II.

Losartan baya hana ayyukan kininase II, enzyme wanda ke cikin metabolism na bradykinin.

Yana rage OPSS, matsin lamba a cikin "karamin" da'irar zagayawa cikin jini, yana rage yawan aiki bayan haka, yana da tasirin diuretic.

Yana sa baki tare da haɓakar hauhawar jini na zuciya, yana ƙaruwa da haƙuri a cikin marasa lafiya tare da rauni na zuciya. Shan losartan sau ɗaya a rana yana haifar da raguwar ƙididdiga a cikin SBP da DBP. Losartan a hankali yana kula da matsa lamba a duk tsawon rana, yayin da tasirin antihypertensive ya dace da yanayin yanayin circadian na dabi'a. Ragewar saukar karfin jini a ƙarshen kashi na miyagun ƙwayoyi ya kasance kusan kashi 70-80% na tasirin cutar, 5-6 hours bayan gudanarwa. Ba'a lura da matsalar rashin lafiya ba, kuma losartan bashi da tasiri mai mahimmanci a ƙimar zuciya.

Losartan yana da tasiri a cikin maza da mata, haka kuma a cikin tsofaffi (sama da shekaru 65) da kuma ƙananan marassa lafiya (underan shekaru 65).

Hydrochlorothiazide. A thiazide diuretic, sakamako na diuretic wanda ake dangantawa da lalacewar reabsorption na sodium, chlorine, potassium, magnesium, ion ruwa a cikin nephron na distal, yana jinkirta ambatar ion alli, uric acid. Ya na da antihypertensive Properties. Kusan babu wani tasiri akan hauhawar jini.

Tasirin diuretic yana faruwa bayan sa'o'i 1-2, ya kai matsakaici bayan sa'o'i 4 sannan ya ɗauki tsawon awanni 6-12. Sakamakon antihypertensive yana faruwa bayan kwanaki 3-4, amma yana iya ɗaukar makonni 3-4 don cimma sakamako mafi kyau na warkewa.

Pharmacokinetics

Magungunan magunguna na losartan da hydrochlorothiazide lokacin da aka ɗauka lokaci guda bai bambanta da lokacin da aka gudanar daban.

Losartan. An gamsu sosai daga narkewa. Yana halayen metabolism mai mahimmanci yayin "hanyar farko" ta hanta, samar da metabolite mai aiki (EXP-3174) tare da acid hydroxylic da sauran metabolites marasa aiki. Kimar bioa kusan kashi 33%. Shan magungunan da abinci bashi da wani tasiri a asibiti a wajan maida hankali. T max - 1 hour bayan maganin baka, da kuma metabolite mai aiki (EXP-3174) - 3-4 awanni.

Fiye da 99% na losartan da EXP-3174 sun ɗaure zuwa sunadaran plasma, galibi tare da albumin. Ofimar rarraba losartan shine lita 34. Tana ratsa jiki sosai ta cikin BBB.

Losartan yana metabolized tare da ƙirƙirar metabolite mai aiki (EXP-3174) metabolite (14%) da kuma rashin aiki, ciki har da manyan metabolites 2 waɗanda aka kafa ta hanyar hydroxylation na butyl rukuni na sarkar, da ƙarancin metabolite - N-2-tetrazole glucuronide.

Theaddamar da ƙwayar plasma na losartan da metabolite mai aiki shine kimanin 10 ml / s (600 ml / min) da 0.83 ml / s (50 ml / min), bi da bi. Batun danyen danyen losartan da kuma metabolite dinsa mai aiki yakai kimanin 1.23 ml / s (74 ml / min) da 0.43 ml / s (26 ml / min). T 1/2 na losartan da metabolite mai aiki sune 2 sa'o'i da 6-9 hours, bi da bi. An keɓe shi musamman da bile - 58%, kodan - 35%.

Hydrochlorothiazide. Bayan gudanar da baki, sha na hydrochlorothiazide kashi 60-80%. C max hydrochlorothiazide a cikin jini ana samun sa'o'i 1-5 bayan fitowar.

Abubuwan da ke ɗaure ga ƙwayoyin plasma na hydrochlorothiazide shine 64%.

Hydrochlorothiazide ba metabolized bane kuma yana fitowa cikin sauri cikin hanta. T 1/2 shine 5-15 hours.

Yanayi na musamman

• Shafin 1 losartan potassium 100 MG hydrochlorothiazide 25 MG Abubuwan da ke ciki: sitaci na pregelatinized sitaci - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Abun da ke cikin membrane fim: hypromellose - 10 mg, macrogol 4000 - 1 mg, fenti quinoline rawaya (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potassium 100 MG hydrochlorothiazide 12.5 MG Abubuwan da aka ƙaddara: sitaci na pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc. losartan potassium 100 MG hydrochlorothiazide 25 MG na musamman: pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Abubuwan da ke ciki: sitaci precilatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate Harshin Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), tal. losartan potassium 50 mg hydrochlorothiazide 12.5 mg Masu haɓaka: pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc.

Lorista N contraindications

• Hypersensitivity ga losartan, zuwa magungunan da aka samo daga sulfonamides da sauran abubuwan da ke tattare da miyagun ƙwayoyi, anuria, matsanancin ƙarancin renal (ƙaddamarwar creatinine (CC kasa da 30 ml / min.), Hyperkalemia, rashin ruwa (ciki har da babban allurai na diuretics) matsanancin rashin lafiyar hanta, nakuda hypokalemia, ciki, lactation, jijiyoyin jini, shekaru a karkashin shekaru 18 (ba a tsaida inganci da aminci ba), rashi lactase, galactosemia ko cutar glucose / gal malabsorption syndrome Ayyuka. Tare da taka tsantsan: daidaitawar jini-electrolyte damuwa damuwa (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), ƙwaƙwalwar ƙwayar jijiyoyin hannu ko ƙanƙantar ƙwayar jijiya guda ɗaya, cututtukan ƙwayar cuta, hauhawar jini, hauhawar jini da hyperuricemia da / ko gout, wata cuta mai lalata haɓaka a baya tare da wasu kwayoyi, gami da masu hana AP

Lorista N sakamako masu illa

• A wani ɓangaren jini da tsarin lymphatic: na kullun: rashin jini, Shenlane-Genokha purpura. A wani ɓangare na rigakafi: da wuya: halayen anaphylactic, angioedema (ciki har da kumburin farji da harshe, haifar da toshewar hanyoyin iska da / ko kumburin fuska, lebe, hanji). Daga gefen tsarin juyayi na tsakiya da tsarin juyayi na jiki: sau da yawa: ciwon kai, rashin tsari da rashin tsari, rashin bacci, gajiya, marassa galibi: migraine. Daga tsarin zuciya: sau da yawa: orthostatic hypotension (dogara-kashi), palpitations, tachycardia, da wuya: vasculitis. Daga tsarin numfashi: sau da yawa: tari, cututtukan hanji na sama, hanji, kumburin hanci. Daga cikin jijiyoyin mahaifa: sau da yawa: zawo, dyspepsia, tashin zuciya, amai, ciwon ciki. Daga tsarin hepatobiliary: da wuya: hepatitis, aikin hanta mai rauni. Daga fata da mai kitse mai alaƙa: akai akai: urticaria, itching fata. Daga tsarin musculoskeletal da nama mai haɗuwa: sau da yawa: myalgia, ciwon baya, maras-wuya: arthralgia. Sauran: sau da yawa: asthenia, rauni, yanki na ciki, ciwon kirji. Manuniyar dakin gwaje-gwaje: sau da yawa: hyperkalemia, haɓaka taro na haemoglobin da hematocrit (ba mahimmanci a asibiti), ba a sauƙaƙe ba: matsakaiciyar haɓaka a cikin ƙwayoyin magani na urea da creatinine, da wuya: ƙara yawan aiki na hanta da enzymes bilirubin.

Yanayin ajiya

• adana a zazzabi daki 15-25
• nisantar da yara

Kowace shekara, mutane da yawa suna shan wahala daga ci gaban cututtukan zuciya. A cewar kididdigar, kwanan nan, har ma da kananan yara sun fuskanci wannan matsala. A yau, akwai magunguna da yawa waɗanda ke taimakawa wajen yaƙar hare-hare na hauhawar jini. Ofayan mafi inganci shine Lorista N.

Lorista N magani ne wanda yake da alaƙa. Abubuwan da ke cikin jikinta suna daidaita karfin jini da taimakawa kawar da buguwa ta zuciya. Tabbatacce tabbatacce na allunan an tabbatar da su ta hanyar babban sashi mai aiki -. Yana tsokani inhibition na angiotensin II masu karɓa a cikin zuciya, jijiyoyin jini da kodan. A sakamakon wannan, ana lura da raguwa na vasoconstriction.

Ba kamar Lorista ba

A cikin kantin magunguna na Rasha, ana sayar da samfurori da yawa iri ɗaya a lokaci daya - Lorista N kuma yawancinsu ba su san menene bambanci tsakanin su ba.

Babban bambanci yana cikin tsarin magungunan. A Lorista, losartan shima babban kayan aiki ne. Ana yin aikin ƙarin abubuwan haɗin gwiwa ta: sitaci masara, cellactose, magnesium stearate.

A cikin ingantacciyar sigar wannan magani tare da prefix H, an inganta jerin ta hydrochlorothiazide. Yana taimakawa rage Na + a matakin yanki na reabsorption kashi. Hakanan babu buƙatar kowane ɗayan daban-daban zaɓi sigogin farko don marasa lafiya da tsufa.

Wani bambanci tsakanin waɗannan magunguna shine farashi. Matsakaicin farashin Lorista ya ɗan ragu kaɗan kuma ya kai 100-130 rubles. Amma ga tsarin aiki, duka magunguna suna taimakawa rage karfin jini.

Tsarin da farashin farashin magani

Ana samun magungunan a cikin nau'ikan allunan da ke da launin shuɗi. Wani lokaci akwai allunan launin kore. Su ƙanana ne ƙanƙanta da sihiri a sifa, wanda ke sa liyafar ta dace kamar yadda zai yiwu. A gefe ɗaya akwai layin rarrabuwa (Lorista ND, tare da babban abun ciki na bangaren aiki, ba ya nan).

Bayan wucewa jarrabawa da kuma tuntuɓi kwararrun likita, mai haƙuri zai iya fahimtar abin da ya fi dacewa a cikin yanayin musamman - N ko ND. Ba shi da daraja a gaya wa kanka magani, don kada a cutar da jiki. Matsakaicin matsakaici shine 230 rubles.

Abun ciki, tsarin aiki da kaddarorin

Kowane kwamfutar hannu an rufe ta da fim kuma tana dauke da: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), sitaci masara pregelatinized, MCC, magnesium stearate da lactose monohydrate. Hakanan, ana samun allunan tare da haɓaka abun ciki na losartan (100 MG). Ana kiransu Lorista ND. 25 M na hydrochlorodisiad an kara su a cikin abun da ke ciki. Karin kayan aikin ya kasance iri daya ne.

Don kera fim ɗin fim, masana'antun suna amfani da talc, launin shuɗi, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Hanyar aiwatar da abubuwanda ke aiki shine rage karfin jini da rage kaya bayan zuciya. Abubuwan da ke cikin allunan suna ba da gudummawa ga haɓaka aikin plasma renin, raguwa a cikin ƙwayoyin ƙwaƙwalwar ƙwayar ƙwaƙwalwar ƙwaƙwalwa tare da haɓaka ƙwayar aldosterone.

Babban abu na miyagun ƙwayoyi yana halin aikin uricosuric. Yana toshe sakamakon ilmin likitan dabbobi na angiotensin II. Tare tare da hydrochlorothiazide, abu yana rage rage hyperuricemia. Magungunan ba zai tasiri da yawan lokutan rikicewar ƙwayar zuciya. Ana aiwatar da tasirin antihypertensive ta hanyar fadada jijiyoyin jini. Bayan sa'o'i 2-3, sakamako yana faruwa wanda zai iya kwana ɗaya.

Losartan yana da kyau sosai daga ƙwayar gastrointestinal, matakin bioavailability shine 32-33%. Abubuwan da ke ɗaure sunadaran sunadaran plasma. Kimanin kashi 58% na magungunan an cire su daga jiki tare da bile, kuma kashi 35% na kodan ya keɓe shi. Bayan shigowa, hydrochlorothiazide ya haɗu da sunadaran plasma (kusan 65%). A tsakanin awanni 5-10 daga jiki tare da fitsari.

Alamu da iyakancewa

Magungunan yana ɗauka azaman ɗayan abubuwan da ke tattare da rikicewar jiyya a cikin binciken cutar hawan jini. Hakanan alamu sun hada da:

1. Rage haɗarin haɓakar jijiyoyin jini da cututtukan zuciya.
2. Cire alamun marasa amfani tare da hauhawar jini ventricular hagu.

Hagu na ventricular hauhawar jini

Lorista N yana da contraindications da yawa, waɗanda ya kamata a biya su kulawa ta musamman kafin ɗauka:

• bushewa
• rashin lactose a jiki,
• rashin lafiya
• na gazawar
• karancin jini
• ciki
• mutum rashin haƙuri ko rashin jituwa ga abubuwan da aka gyara.

Hakanan, ba a ba da magani ga yara 'yan ƙasa da shekara 18. Tare da gout, ciwon sukari, asma, cututtukan jini, an yarda da miyagun ƙwayoyi, amma a ƙarƙashin tsananin kulawa na likitan halartar.

Kai magani na iya tsananta halin. Kafin shan maganin, kuna buƙatar gano wane irin matsa lamba aka wajabta shi.

Umarnin don amfani

Magungunan an yi shi ne don gudanar da maganin baka, ba tare da la'akari da abincin ba. An yarda da haɗarin ci tare da kwayoyi don rage karfin jini. Sashi ya dogara da nau'in cutar sankara.

Dangane da umarnin don amfani, tare da hauhawar jini a kowace rana, an ba shi izinin ɗaukar kwamfutar hannu 1. Matsakaicin sashi shine guda biyu. Bukatar ƙara yawan kashi an ƙaddara ta likita mai halartar.

Lokacin da ake bincika haguwar jini na ventricular hagu, kashi na farko na yau da kullun shine 50 MG, wato, kwamfutar hannu 1. Da safe ko da yamma - ba matsala.

Marasa lafiya suna sha'awar ko za su sha maganin har abada ko a'a. Don matsin lamba don daidaita al'ada da alamun cutar ta koma baya, wajibi ne a gudanar da cikakken darasi (kamar kwana 30). Bayan haka, likitan da ke halartar zai jagoranci wani gwajin kuma ya ba da rahoto game da ƙarin matakan. Tare da maimaita hare-hare, ƙila kuna buƙatar sake yin hanya.

Yana da mahimmanci la'akari da hulɗa da miyagun ƙwayoyi:

Side effects da yawan abin sama da ya kamata

Idan an sha miyagun ƙwayoyi ta hanyar da ba ta dace ba, sakamakon da ba a so na iya faruwa (Jadawalin 2).

Hakanan, sakamakon illa na iya faruwa ta hanyar fitsari a fatar, wanda yana tare da itching. Game da yawan abin sama da ya kamata, mai haƙuri yana da:

• karancin bradycardia / tachycardia,
• raguwar hauhawar jini,
• hyponatremia,
• hypochloremia.

Idan alamun farko na yawan abin sama da ya kamata ya bayyana, lallai ne a nemi shawarar kwararre. Taimako na farko a cikin irin waɗannan lokuta shine lavage na ciki. Bugu da ari, mai haƙuri zai buƙaci maganin kwantar da hankali.

Don lura da cututtukan zuciya da jijiyoyin jini, da cutar hawan jini, ana kuma amfani da madadin Lorista N. A mafi yawan lokuta, wannan buƙatar ta taso dangane da rashin haƙuri na wasu abubuwan.

Bugu da ƙari, wasu analogues sun fi araha Lorista N. Jerin magunguna tare da irin kayan aikin da aka haɗa sun haɗa da:

1. Co-Centor (50 mg). Kudin su 130 rubles ne.
2. (A'a. 30). Ana iya siyar da kantin don 100-110 rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Kafin maye gurbin magani wanda likita ya wajabta shi, ya wajaba a tattauna tare dashi don kada ya tsokani faruwar haɗarin.

Abun da ya shafi da nau'in magani

Allunan mai rufe fim daga launin rawaya zuwa rawaya tare da tint na launin kore, m, ƙaramin biconvex, tare da haɗari a gefe ɗaya, nau'in kwamfutar hannu a sashin giciye shine ainihin farin kwamfutar hannu.

Wadanda suka karu: pregelatinized sitaci - 34.92 mg, microcrystalline cellulose - 87.7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Tsarin fim ɗin harsashi: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, fenti quinoline rawaya (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0.5 mg.

10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (6) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (9) - fakitoci na kwali.

Aikin magunguna

Aikin magunguna - hypotensive .

Pharmacodynamics

Lorista ® N - hada magunguna, yana da tasirin gaske.

Losartan. Zaɓin mai karɓar angiotensin II mai antagonist (nau'in AT 1) don gudanar da maganin baka, yanayin rashin furotin. A cikin vivo da a cikin vitro losartan da biocarically carboxy metabolite (EXP-3174) suna toshe duk mahimmancin ilimin halittar jiki na angiotensin II akan masu karɓar AT 1.

Losartan kai tsaye yana haifar da kunnawa ga masu karɓar AT 2 ta hanyar haɓaka matakin angiotensin II.

Losartan baya hana ayyukan kininase II, enzyme wanda ke cikin metabolism na bradykinin.

Yana rage OPSS, matsin lamba a cikin "karamin" da'irar zagayawa cikin jini, yana rage yawan aiki bayan haka, yana da tasirin diuretic.

Yana sa baki tare da haɓakar hauhawar jini na zuciya, yana ƙaruwa da haƙuri a cikin marasa lafiya tare da rauni na zuciya. Shan losartan sau ɗaya a rana yana haifar da raguwar ƙididdiga a cikin SBP da DBP. Losartan a hankali yana kula da matsa lamba a duk tsawon rana, yayin da tasirin antihypertensive ya dace da yanayin yanayin circadian na dabi'a. Ragewar saukar karfin jini a ƙarshen kashi na miyagun ƙwayoyi ya kasance kusan kashi 70-80% na tasirin cutar, 5-6 hours bayan gudanarwa. Ba'a lura da matsalar rashin lafiya ba, kuma losartan bashi da tasiri mai mahimmanci a ƙimar zuciya.

Losartan yana da tasiri a cikin maza da mata, haka kuma a cikin tsofaffi (sama da shekaru 65) da kuma ƙananan marassa lafiya (underan shekaru 65).

Hydrochlorothiazide. A thiazide diuretic, sakamako na diuretic wanda ake dangantawa da lalacewar reabsorption na sodium, chlorine, potassium, magnesium, ion ruwa a cikin nephron na distal, yana jinkirta ambatar ion alli, uric acid. Ya na da antihypertensive Properties. Kusan babu wani tasiri akan hauhawar jini.

Tasirin diuretic yana faruwa bayan sa'o'i 1-2, ya kai matsakaici bayan sa'o'i 4 sannan ya ɗauki tsawon awanni 6-12. Sakamakon antihypertensive yana faruwa bayan kwanaki 3-4, amma yana iya ɗaukar makonni 3-4 don cimma sakamako mafi kyau na warkewa.

Contraindications

Hypersensitivity ga losartan, ga samfuran da aka samo daga sulfonamides da sauran abubuwan haɗin maganin, rashin lafiyar jiki, raunin ƙwayar cuta mai rauni (Cl creatinine shekaru 65) da ƙananan marasa lafiya (

Pharmacokinetics

Yanayi na musamman

• Shafin 1 losartan potassium 100 MG hydrochlorothiazide 25 MG Abubuwan da ke ciki: sitaci na pregelatinized sitaci - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Abun da ke cikin membrane fim: hypromellose - 10 mg, macrogol 4000 - 1 mg, fenti quinoline rawaya (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potassium 100 MG hydrochlorothiazide 12.5 MG Abubuwan da aka ƙaddara: sitaci na pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc. losartan potassium 100 MG hydrochlorothiazide 25 MG na musamman: pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Abubuwan da ke ciki: sitaci precilatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate Harshin Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), tal. losartan potassium 50 mg hydrochlorothiazide 12.5 mg Masu haɓaka: pregelatinized sitaci, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Harshen Shell: hypromellose, macrogol 4000, quinoline mai launin shuɗi (E104), titanium dioxide (E171), talc.

Alamar Lorista N

• * Hauhawar jini na jijiya (ga marasa lafiya waɗanda aka nuna haɗuwa tare da jiyya). * Rage haɗarin kamuwa da cututtukan zuciya da mace-mace a cikin marasa lafiya tare da hauhawar jini da haguwar ventricular hagu.

Lorista N contraindications

• Hypersensitivity ga losartan, zuwa magungunan da aka samo daga sulfonamides da sauran abubuwan da ke tattare da miyagun ƙwayoyi, anuria, matsanancin ƙarancin renal (ƙaddamarwar creatinine (CC kasa da 30 ml / min.), Hyperkalemia, rashin ruwa (ciki har da babban allurai na diuretics) matsanancin rashin lafiyar hanta, nakuda hypokalemia, ciki, lactation, jijiyoyin jini, shekaru a karkashin shekaru 18 (ba a tsaida inganci da aminci ba), rashi lactase, galactosemia ko cutar glucose / gal malabsorption syndrome Ayyuka. Tare da taka tsantsan: daidaitawar jini-electrolyte damuwa damuwa (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), ƙwaƙwalwar ƙwayar jijiyoyin hannu ko ƙanƙantar ƙwayar jijiya guda ɗaya, cututtukan ƙwayar cuta, hauhawar jini, hauhawar jini da hyperuricemia da / ko gout, wata cuta mai lalata haɓaka a baya tare da wasu kwayoyi, gami da masu hana AP

Lorista H sashi

• 100 mg + 25 mg 12.5 mg + 100 mg 12.5 mg + 50 mg 25 mg + 100 mg 25 mg + 100 mg 50 mg + 12.5 mg

Lorista N sakamako masu illa

• A wani ɓangaren jini da tsarin lymphatic: na kullun: rashin jini, Shenlane-Genokha purpura. A wani ɓangare na rigakafi: da wuya: halayen anaphylactic, angioedema (ciki har da kumburin farji da harshe, haifar da toshewar hanyoyin iska da / ko kumburin fuska, lebe, hanji). Daga gefen tsarin juyayi na tsakiya da tsarin juyayi na jiki: sau da yawa: ciwon kai, rashin tsari da rashin tsari, rashin bacci, gajiya, marassa galibi: migraine. Daga tsarin zuciya: sau da yawa: orthostatic hypotension (dogara-kashi), palpitations, tachycardia, da wuya: vasculitis. Daga tsarin numfashi: sau da yawa: tari, cututtukan hanji na sama, hanji, kumburin hanci. Daga cikin jijiyoyin mahaifa: sau da yawa: zawo, dyspepsia, tashin zuciya, amai, ciwon ciki. Daga tsarin hepatobiliary: da wuya: hepatitis, aikin hanta mai rauni. Daga fata da mai kitse mai alaƙa: akai akai: urticaria, itching fata. Daga tsarin musculoskeletal da nama mai haɗuwa: sau da yawa: myalgia, ciwon baya, maras-wuya: arthralgia. Sauran: sau da yawa: asthenia, rauni, yanki na ciki, ciwon kirji. Manuniyar dakin gwaje-gwaje: sau da yawa: hyperkalemia, haɓaka taro na haemoglobin da hematocrit (ba mahimmanci a asibiti), ba a sauƙaƙe ba: matsakaiciyar haɓaka a cikin ƙwayoyin magani na urea da creatinine, da wuya: ƙara yawan aiki na hanta da enzymes bilirubin.

Hulɗa da ƙwayoyi

Yawan abin sama da ya kamata

Yanayin ajiya

• adana a zazzabi daki 15-25
• nisantar da yara

Kowace shekara, mutane da yawa suna shan wahala daga ci gaban cututtukan zuciya. A cewar kididdigar, kwanan nan, har ma da kananan yara sun fuskanci wannan matsala. A yau, akwai magunguna da yawa waɗanda ke taimakawa wajen yaƙar hare-hare na hauhawar jini. Ofayan mafi inganci shine Lorista N.

Lorista N magani ne wanda yake da alaƙa. Abubuwan da ke cikin jikinta suna daidaita karfin jini da taimakawa kawar da buguwa ta zuciya. Tabbatacce tabbatacce na allunan an tabbatar da su ta hanyar babban sashi mai aiki -. Yana tsokani inhibition na angiotensin II masu karɓa a cikin zuciya, jijiyoyin jini da kodan. A sakamakon wannan, ana lura da raguwa na vasoconstriction.

Ba kamar Lorista ba

A cikin kantin magunguna na Rasha, ana sayar da samfurori da yawa iri ɗaya a lokaci daya - Lorista N kuma yawancinsu ba su san menene bambanci tsakanin su ba.

Babban bambanci yana cikin tsarin magungunan. A Lorista, losartan shima babban kayan aiki ne. Ana yin aikin ƙarin abubuwan haɗin gwiwa ta: sitaci masara, cellactose, magnesium stearate.

A cikin ingantacciyar sigar wannan magani tare da prefix H, an inganta jerin ta hydrochlorothiazide. Yana taimakawa rage Na + a matakin yanki na reabsorption kashi. Hakanan babu buƙatar kowane ɗayan daban-daban zaɓi sigogin farko don marasa lafiya da tsufa.

Wani bambanci tsakanin waɗannan magunguna shine farashi. Matsakaicin farashin Lorista ya ɗan ragu kaɗan kuma ya kai 100-130 rubles. Amma ga tsarin aiki, duka magunguna suna taimakawa rage karfin jini.

Tsarin da farashin farashin magani

Ana samun magungunan a cikin nau'ikan allunan da ke da launin shuɗi. Wani lokaci akwai allunan launin kore. Su ƙanana ne ƙanƙanta da sihiri a sifa, wanda ke sa liyafar ta dace kamar yadda zai yiwu. A gefe ɗaya akwai layin rarrabuwa (Lorista ND, tare da babban abun ciki na bangaren aiki, ba ya nan).

Bayan wucewa jarrabawa da kuma tuntuɓi kwararrun likita, mai haƙuri zai iya fahimtar abin da ya fi dacewa a cikin yanayin musamman - N ko ND. Ba shi da daraja a gaya wa kanka magani, don kada a cutar da jiki. Matsakaicin matsakaici shine 230 rubles.

Abun ciki, tsarin aiki da kaddarorin

Kowane kwamfutar hannu an rufe ta da fim kuma tana dauke da: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), sitaci masara pregelatinized, MCC, magnesium stearate da lactose monohydrate. Hakanan, ana samun allunan tare da haɓaka abun ciki na losartan (100 MG). Ana kiransu Lorista ND. 25 M na hydrochlorodisiad an kara su a cikin abun da ke ciki. Karin kayan aikin ya kasance iri daya ne.

Don kera fim ɗin fim, masana'antun suna amfani da talc, launin shuɗi, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Hanyar aiwatar da abubuwanda ke aiki shine rage karfin jini da rage kaya bayan zuciya. Abubuwan da ke cikin allunan suna ba da gudummawa ga haɓaka aikin plasma renin, raguwa a cikin ƙwayoyin ƙwaƙwalwar ƙwayar ƙwaƙwalwar ƙwaƙwalwa tare da haɓaka ƙwayar aldosterone.

Babban abu na miyagun ƙwayoyi yana halin aikin uricosuric. Yana toshe sakamakon ilmin likitan dabbobi na angiotensin II. Tare tare da hydrochlorothiazide, abu yana rage rage hyperuricemia. Magungunan ba zai tasiri da yawan lokutan rikicewar ƙwayar zuciya. Ana aiwatar da tasirin antihypertensive ta hanyar fadada jijiyoyin jini. Bayan sa'o'i 2-3, sakamako yana faruwa wanda zai iya kwana ɗaya.

Losartan yana da kyau sosai daga ƙwayar gastrointestinal, matakin bioavailability shine 32-33%. Abubuwan da ke ɗaure sunadaran sunadaran plasma. Kimanin kashi 58% na magungunan an cire su daga jiki tare da bile, kuma kashi 35% na kodan ya keɓe shi. Bayan shigowa, hydrochlorothiazide ya haɗu da sunadaran plasma (kusan 65%). A tsakanin awanni 5-10 daga jiki tare da fitsari.

Alamu da iyakancewa

Magungunan yana ɗauka azaman ɗayan abubuwan da ke tattare da rikicewar jiyya a cikin binciken cutar hawan jini. Hakanan alamu sun hada da:

1. Rage haɗarin haɓakar jijiyoyin jini da cututtukan zuciya.
2. Cire alamun marasa amfani tare da hauhawar jini ventricular hagu.

Hagu na ventricular hauhawar jini

Lorista N yana da contraindications da yawa, waɗanda ya kamata a biya su kulawa ta musamman kafin ɗauka:

• bushewa
• rashin lactose a jiki,
• rashin lafiya
• na gazawar
• karancin jini
• ciki
• mutum rashin haƙuri ko rashin jituwa ga abubuwan da aka gyara.

Hakanan, ba a ba da magani ga yara 'yan ƙasa da shekara 18. Tare da gout, ciwon sukari, asma, cututtukan jini, an yarda da miyagun ƙwayoyi, amma a ƙarƙashin tsananin kulawa na likitan halartar.

Kai magani na iya tsananta halin. Kafin shan maganin, kuna buƙatar gano wane irin matsa lamba aka wajabta shi.

Umarnin don amfani

Magungunan an yi shi ne don gudanar da maganin baka, ba tare da la'akari da abincin ba. An yarda da haɗarin ci tare da kwayoyi don rage karfin jini. Sashi ya dogara da nau'in cutar sankara.

Dangane da umarnin don amfani, tare da hauhawar jini a kowace rana, an ba shi izinin ɗaukar kwamfutar hannu 1. Matsakaicin sashi shine guda biyu. Bukatar ƙara yawan kashi an ƙaddara ta likita mai halartar.

Lokacin da ake bincika haguwar jini na ventricular hagu, kashi na farko na yau da kullun shine 50 MG, wato, kwamfutar hannu 1. Da safe ko da yamma - ba matsala.

Marasa lafiya suna sha'awar ko za su sha maganin har abada ko a'a. Don matsin lamba don daidaita al'ada da alamun cutar ta koma baya, wajibi ne a gudanar da cikakken darasi (kamar kwana 30). Bayan haka, likitan da ke halartar zai jagoranci wani gwajin kuma ya ba da rahoto game da ƙarin matakan. Tare da maimaita hare-hare, ƙila kuna buƙatar sake yin hanya.

Yana da mahimmanci la'akari da hulɗa da miyagun ƙwayoyi:

Side effects da yawan abin sama da ya kamata

Idan an sha miyagun ƙwayoyi ta hanyar da ba ta dace ba, sakamakon da ba a so na iya faruwa (Jadawalin 2).

Hakanan, sakamakon illa na iya faruwa ta hanyar fitsari a fatar, wanda yana tare da itching. Game da yawan abin sama da ya kamata, mai haƙuri yana da:

• karancin bradycardia / tachycardia,
• raguwar hauhawar jini,
• hyponatremia,
• hypochloremia.

Idan alamun farko na yawan abin sama da ya kamata ya bayyana, lallai ne a nemi shawarar kwararre. Taimako na farko a cikin irin waɗannan lokuta shine lavage na ciki. Bugu da ari, mai haƙuri zai buƙaci maganin kwantar da hankali.

Don lura da cututtukan zuciya da jijiyoyin jini, da cutar hawan jini, ana kuma amfani da madadin Lorista N. A mafi yawan lokuta, wannan buƙatar ta taso dangane da rashin haƙuri na wasu abubuwan.

Bugu da ƙari, wasu analogues sun fi araha Lorista N. Jerin magunguna tare da irin kayan aikin da aka haɗa sun haɗa da:

1. Co-Centor (50 mg). Kudin su 130 rubles ne.
2. (A'a. 30). Ana iya siyar da kantin don 100-110 rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Kafin maye gurbin magani wanda likita ya wajabta shi, ya wajaba a tattauna tare dashi don kada ya tsokani faruwar haɗarin.

Abun da ya shafi da nau'in magani

Allunan mai rufe fim daga launin rawaya zuwa rawaya tare da tint na launin kore, m, ƙaramin biconvex, tare da haɗari a gefe ɗaya, nau'in kwamfutar hannu a sashin giciye shine ainihin farin kwamfutar hannu.

Wadanda suka karu: pregelatinized sitaci - 34.92 mg, microcrystalline cellulose - 87.7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Tsarin fim ɗin harsashi: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, fenti quinoline rawaya (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0.5 mg.

10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (6) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (9) - fakitoci na kwali.

Aikin magunguna

Daidaita wakili na antihypertensive. Losartan da hydrochlorothiazide suna da tasirin antihypertensive, suna rage hawan jini zuwa girman da yafi kowane ɗayan abubuwan daban.

Losartan mai zaɓar mai adawa ne na masu karɓar angiotensin II (nau'in AT 1) don gudanar da maganin baka. A cikin vivo da in vitro, losartan da likitanciki mai aiki na E-3174 suna toshe duk wani abu mai mahimmanci na jijiyoyin jini na angiotensin II akan masu karɓar AT 1, ba tare da la'akari da hanyar da aka kirkira shi ba: yana haifar da karuwa a cikin aikin renin jini da raguwa a cikin taro na aldosterone a cikin jini na jini. Losartan kai tsaye yana haifar da kunnawar masu karɓar AT 2 ta hanyar karɓar taro na angiotensin II.Ba ya hana aikin kininase II, enzyme wanda ke da hannu a cikin metabolism na bradykinin. Yana rage OPSS, matsin lamba a cikin jijiyoyin mahaifa, yana rage kaya bayan saukarwar myocardium, yana da tasirin diuretic. Yana rikicewa tare da haɓakar hauhawar jini na myocardial, yana ƙaruwa da haƙuri a cikin marasa lafiya tare da rauni na zuciya (CHF). Shan losartan 1 lokaci / rana yana haifar da raguwar ƙididdiga a systolic da hauhawar jini.

Losartan a hankali yana sarrafa hawan jini yayin rana, yayin da tasirin antihypertensive ya dace da yanayin rawar jiki na circadian. Raguwar saukar karfin jini a ƙarshen kashi na miyagun ƙwayoyi ya kasance kusan 70-80% na mafi girman tasirin losartan, 5-6 hours bayan shigowa. Babu ciwon cirewa.

Losartan bashi da tasirin gaske a cikin ƙwayar zuciya, yana da tasiri matsakaici mai sauƙaƙewa.

Hydrochlorothiazide- a thiazide diuretic, sakamako na diuretic wanda aka danganta shi da cin zarafi na reabsorption na sodium, chlorine, potassium, magnesium, ion na ruwa a cikin nephron na distal, yana jinkirta ambatar ion alli, uric acid. Yana da tasiri mai ƙwarin gwiwa, aikin wanda ke haɓakawa saboda fadada arterioles. Kusan babu wani tasiri akan hauhawar jini. Tasirin diuretic yana faruwa bayan sa'o'i 1-2, ya kai matsakaici bayan sa'o'i 4 sannan yana ɗaukar tsawon awanni 6-12. Matsakaicin sakamako na antihypertensive yana faruwa bayan kwanaki 3-4, amma yana iya ɗaukar makonni 3-4 don cimma sakamako mafi kyau na warkewa.

Sakamakon sakamako na diuretic, hydrochlorothiazide yana ƙaruwa aikin plasma renin, yana ƙarfafa ɓoyewar aldosterone, yana ƙara haɗarin angiotensin II kuma yana rage taro na potassium a cikin jini na jini. Karɓar losartan toshe duk abubuwan ilimin halittar jiki na angiotensin II kuma, saboda ɓoyewar tasirin aldosterone, zai iya taimakawa rage asarar potassium da ke haɗuwa da shan diuretic. Hydrochlorothiazide yana haifar da ƙara ƙima a cikin yawan uric acid a cikin jini, haɗuwa da losartan da hydrochlorothiazide yana taimakawa rage ƙwanƙwasawar cututtukan hyperuricemia da ke haifar da diuretic.

Pharmacokinetics

Magungunan magunguna na losartan da hydrochlorothiazide tare da yin amfani da lokaci ɗaya ba ya bambanta da amfaninsu da monotherapy.

Bayan gudanar da baki, losartan yana da kyau daga narkewa. Yana halayen metabolism mai mahimmanci yayin "hanyar farko" ta hanta, samarda mai aiki na pharmacologically aiki metabolxy metabolite (E-3174) da kuma metabolites marasa aiki. Kimar bioa kusan kashi 33%. Matsakaicin C max na losartan da aiki metabolite suna isa bayan awa 1 da bayan awa 3-4, bi da bi. Losartan da aiki na metabolite suna ɗaure sunadaran plasma (galibi c) sama da 99%. V d na losartan shine lita 34. Tana ratsa jiki sosai ta cikin BBB.

Losartan yana metabolized don ƙirƙirar metabolite mai aiki (E-3174) metabolite (14%) da kuma rashin aiki, ciki har da manyan metabolites guda biyu da aka kirkira ta hanyar hydroxylation na butyl rukuni na sarkar da ƙananan metabolite, N-2-tetrazolglucuronide. Theaddamar da ƙwayar plasma na losartan da metabolite mai aiki shine kimanin 10 ml / sec (600 ml / min) da 0.83 ml / sec (50 ml / min), bi da bi. Batun danyen danne na losartan da kuma metabolite dinsa mai aiki shine kusan 1.23 ml / sec (74 ml / min) da 0.43 ml / sec (26 ml / min). T 1/2 na losartan da metabolite mai aiki shine 2 hours da 6-9 hours, daidai da. An cire shi musamman da bile ta cikin hanji - 58%, kodan - 35%. Shin, ba ya tarawa.

Lokacin da aka sha shi ta baki a allurai har zuwa 200 MG, losartan da ingantaccen metabolite suna da magungunan layi.

Bayan gudanar da baki, sha na hydrochlorothiazide kashi 60-80%. Ana samun C max a cikin jini (plasma) na jini 1-5 hours bayan shigowa. Haɗawa ga furotin jini na jini - 64%. Har ila yau, ya shiga cikin hanyar shinge. Cire cikin madara mai nono. Hydrochlorothiazide ba metabolized ba kuma yara da yara sun cire shi da sauri. T 1/2 shine awa 5-15. Aƙalla kashi 61% na maganin da aka sha da baki an cire shi ba a cikin sa'o'i 24 ba.

Hauhawar jini na jijiya (ga marasa lafiya waɗanda aka nuna haɗuwa tare da jiyya), raguwa a cikin haɗarin kamuwa da cututtukan zuciya da mace-mace a cikin marasa lafiya da hauhawar jini da jijiyoyin jini na hagu.

Contraindications

Anuria, gawurtaccen renal (CC