Magunguna don asarar nauyi da tsufa - Dr. Malysheva game da Metformin

Sannan Malysheva yayi magana game da Metformin, babu wanda ya gwada shi

Metformin (dimethylbiguanide) wakili ne na antidiabetic don amfanin ciki, wanda ya kasance cikin rukunan biguanides. Inganci na Metformin yana da alaƙa da ikon abu mai aiki don hana gluconeogenesis a cikin jiki. Abubuwan da ke aiki suna hana jigilar wayoyin lantarki daga cikin sarkar na numfashi na mitochondria. Wannan yana haifar da raguwa a cikin taro na ATP a cikin sel da kuma haɓakar glycolysis, ana aiwatarwa ta hanyar da ba a sami oxygen ba. A sakamakon wannan, tasirin glucose a cikin sel daga sararin samaniya yana ƙaruwa, kuma samar da lactate da pyruvate a cikin hanta, hanji, adipose da ƙwayoyin tsoka suna ƙaruwa. Shagon Glycogen a cikin sel hanta kuma yana raguwa. Ba ya haifar da tasirin hypoglycemic, tunda ba ya kunna samarwar insulin. Yana rage tsarin hada-hadar mai da mai kuma yana hana samar da kitse na kitse kyauta. A game da tushen amfani da miyagun ƙwayoyi, ana ganin canji a cikin kantin magani na insulin saboda raguwa a cikin rabo na yawan insulin da ke ɗaure insulin kyauta. An kuma gano haɓaka cikin insulin / proinsulin rabo. Sakamakon tsarin aikin miyagun ƙwayoyi, akwai raguwa a matakin glucose a cikin ƙwayar jini bayan cin abinci, alamomin mahimmanci na glucose shima an rage shi. Sakamakon gaskiyar cewa ƙwayar ba ta motsa samar da insulin ta hanyar ƙwayoyin beta na pancreas ba, yana dakatar da hyperinsulinemia, wanda aka ɗauka ɗayan mahimman abubuwan da ke haifar da ƙara girman jikin mutum a cikin ciwon sukari da ci gaban rikicewar jijiyoyin jiki. Decreasearin rage yawan matakan glucose yana faruwa ne saboda haɓaka yawan glucose ta ƙwayoyin tsoka da kuma ƙaruwa cikin hankalin masu karɓar insulin na ƙasa. A cikin mutane masu lafiya (ba tare da ciwon sukari ba) lokacin shan metformin, ba a lura da raguwar matakan glucose. Metformin yana taimakawa rage jiki a cikin kiba da ciwon sukari ta hanyar rage cin abinci, rage shan glucose daga abinci a cikin hanji da motsa jiki anaerobic glycolysis. Metformin kuma yana da tasirin fibrinolytic saboda hanawar PAI-1 (nau'in ƙwayar plasminogen mai kunnawa firikwensin) da kuma t-PA (mai kunna nama plasminogen). Magungunan yana motsa tsarin biotransformation na glucose cikin glycogen, yana motsa jini jini a cikin hanta hanta. Harkokin zubar da jini na jini: rage matakin LDL (ƙarancin lipoproteins mai yawa), triglycerides (da 10-20% har ma da haɓakar farko na 50%) da VLDL (ƙarancin lipoproteins mai yawa sosai). Sakamakon sakamako na rayuwa, metformin yana haifar da karuwa a cikin HDL (babban yawan lipoproteins mai yawa) ta 20-30%. Magungunan yana hana ci gaban yaduwar ƙwayoyin tsoka mai santsi na bangon jirgin ruwa. Yana da tasiri mai kyau akan tsarin zuciya da hana bayyanar cututtukan cututtukan zuciya. Bayan gudanar da baka, mafi girman abubuwan da ke aiki a cikin jini na jini bayan awa 2.5. A cikin marasa lafiyar da suka karɓi ƙwayoyi a cikin iyakar adadin da aka yarda, mafi girman abun ciki na abu mai aiki a cikin jini plasma bai wuce 4 μg / ml ba. Mintuna 6 bayan shan kwaya, ɗaukar abu mai aiki daga magungunan ya ƙare, wanda ke tattare da raguwa a cikin ƙwayar plasma na metformin. Lokacin ɗaukar shawarar da aka ba da shawarar bayan kwanaki 1-2, ana samun yawan ƙwayoyin metformin a cikin jini cikin 1 μg / ml ko ƙasa da hakan. Idan kun sha miyagun ƙwayoyi yayin cin abinci, to, akwai raguwa a cikin shan metformin daga ƙwayar. Metformin galibi yana cakuda shi a jikin bangon narkewa: a ƙanana da duodenum, ciki, harda cikin hanji da hanta. Rabin rayuwar kusan awowi 6.5. Tare da yin amfani da metformin na ciki, cikakken cikakken yanayin rayuwa a cikin mutane masu lafiya kusan 50-60%. Da kyar aka ɗaure su da ƙwayoyin plasma. Yin amfani da ɓoyewar tubular da keɓaɓɓen dunƙule, ƙwayayen sun toshe ta daga 20 zuwa 30% na adadin da aka gudanar (ba a canzawa ba, saboda, ba kamar motsi ba ne, ba metabolized bane). Game da aiki na keɓaɓɓen aiki, ƙarar keɓaɓɓe yana raguwa daidai gwargwado ga ɗaukar hoto, don haka, bi da bi, yawan ƙwayar plasma da rabin rayuwa na metformin yana ƙaruwa daga jiki, wanda zai haifar da tara kayan aiki a cikin jiki.

Menene metformin?

Metformin magani ne na kwamfutar hannu wanda aka yi amfani dashi don ciwon sukari na 2. Ya kasance cikin rukunan biguanides. Yana ɗayan tsofaffi kuma ɗayan ingantattun magunguna waɗanda aka yi amfani da su don magance wannan cutar. Daga aji na biguanides, wannan shine kawai magani wanda ba ya cutar da marasa lafiya da rauni a zuciya. WHO ta sanya shi a jerin magunguna masu mahimmanci.

Metformin shine asalin sunan asalin magani don magani. An gabatar da sunayen kasuwancin da ke gaba akan kasuwar magunguna: Glucofage, Glycomet, Bagomet, Diaformin, Insufor, Langerin, Meglifort, Metamine, Metfogamma, Metformin Sandoz, Metformin-Teva, Panfor Sr, Siofor, Zukronorm.

An dauki dogon lokaci, ana amfani da maganin don maganin ciwon sukari. Bayan bincike na shekaru, an gano cewa yana rage yawan kitse. A gaban cutar sankarar bargo ana iya amfani dashi don rage saurin kamuwa da cutar. Hakanan ana amfani dashi don ƙwayar ƙwayar polycystic da kuma wasu hanyoyin da ake dasu wanda juriya insulin yana da mahimmanci.

An lura fa'idodin metformin:

• tare da ciwon sukari
• tare da ciwo na rayuwa
• a cikin rigakafin cututtukan zuciya,
• a cikin rigakafin cutar kansa.

An tabbatar da rikitaccen sakamako na miyagun ƙwayoyi yayin yaƙar tsufa. Muhimmiyar darajar shine raguwa a jikin mace-mace daga rikicewar cututtukan zuciya. Hakanan an tabbatar da cewa yana rage haɗarin bunkasa oncology a cikin marasa lafiya da ciwon sukari da cututtukan metabolism. Resistancearfin Hormone ɗaya daga cikin haɗarin ciwacewar ciwan daji. Insulin yana karfafa haɓakar nama, gami da rashin kyau sosai.

Ta yaya miyagun ƙwayoyi ke aiki?

Magani na rage taro a cikin jini da kuma aiki na glucose a cikin hanta. Baya ga tasirin hypoglycemic, yana da tasirin gaske yana tasiri ga ƙwaƙwalwar ƙwayar lipid. Wersarancin triglycerides da mummunan cholesterol (LDL). Ita ce kawai magani, a cewar binciken, wanda ke rage yawan bugun zuciya da bugun jini.

Ofaya daga cikin fa'idodin maganin shine cewa ba ya ƙaruwa da nauyin jiki idan aka kwatanta da sauran magunguna na hypoglycemic. Ga mai ciwon sukari, yana taimakawa tsawan rai da kuma sanya rayuwa ta cika da inganci. Aikinsa yana da nufin asarar nauyi. An tsara shi don kiba, idan maganin abinci bai kawo sakamakon da ya dace ba.

Magungunan suna hana ci da sha da glucose a cikin tsarin narkewa. Kunnawa insulin baya faruwa, ana samun sakamako na hypoglycemic ta hanyar haɓaka jijiyoyin jiki da yawan ƙwayar sukari. Sakamakon shan magunguna, hanyoyin kwantar da hankali wanda ke haɓakawa da tushen cutar ya ragu. Ana iya amfani dashi don maganin cututtuka waɗanda ke nuna juriya na insulin. An bayyana tasirin maganin a cikin ƙwayoyin polycystic, cututtukan jini, wasu cututtukan hanta, da kiba.

Metformin yana rage kiba a cikin hanta da kuma haɓaka aikin glycogen. A ƙarƙashin tasirin miyagun ƙwayoyi, ana motsa jini a cikin hanta, an rage matakin triglycerides da cholesterol. Sauƙaƙe na glucose ta tsokoki, babban mai amfani da makamashi, yana sauƙaƙe. Explainedarin yawan amfani da sukari da aka sarrafa ana bayanin shi da gaskiyar cewa yana da sauƙin shiga nama.

Sakamakon shan magungunan:

• rage sukari
• needarancin buƙatar insulin na insulin,
• toshewar insulin juriya,
• rage gudu ko ci gaban atherosclerosis,
• raguwa a cikin triglycerides da LDL
• rage karfin jini, raguwar sinadarin suga,
• tarewa enzymes da ke lalata sel,
• kariya daga jijiyoyin jiki.

Contraindications

Daga cikin contraindications don amfani:

• koda dysfunction
• rashin ƙarfi ga miyagun ƙwayoyi,
• cututtuka a cikin babban mataki,
• ketoacidosis
• hanta dysfunction
• bugun zuciya
• kafin da bayan gwajin rediyo tare da gabatarwar bambanci,
• kafin da bayan tiyata,
• tsufa
• malabsorption B12.

Ciwon sukari

A da, ana amfani da Metformin na musamman don maganin ciwon sukari. Karatun ya nuna cewa kwayar ta nuna wasu kaddarorin. Ana amfani dashi don ƙwayoyin polycystic, kiba, da kuma rigakafin cutar sankara.

Har yanzu, babban mahimmancin metformin shine lura da ciwon sukari na 2. Yana rage sukari da gluconeogenesis, yana rage yawan sikari da LDL, kuma yana dan rage ci. Rage glucose yana faruwa duka a kan komai a ciki da bayan abinci. Jikin tsoka yana karɓar adadin glucose mai yawa saboda ƙaruwa a amfani da shi. Rage yawan sukari a cikin narkewa yana raguwa.

Magungunan ba ya motsa samar da hormone. Ana samun sakamako mai narkewar sukari ta hanyar haɓaka karɓar glucose ta nama. A yayin jiyya tare da Metformin, an rage buƙatar insulin. Kayan aiki yana rage haɗarin rikitarwa da mace-mace ta kusan 35% idan aka kwatanta da sauran magungunan hypoglycemic da insulin na injection.

Matsayi na glucose na yau da kullun yana da haɗari ga tsarin zuciya. Wani nau'i na sikelin akan bangon tasoshin, microcirculation yana da damuwa. Daga nan akwai raunuka na idanu, jijiyoyin jini na kwakwalwa da zuciya, tasoshin kafafu da makamantansu.

Lokacin ɗaukar miyagun ƙwayoyi, ba a lura da mummunan sakamako na hypoglycemic ba. Ya danganta da matakin sukari da tsaida glycemia, mai haƙuri na iya shan wani abu. Amma tunda an wajabta maganin, yana yiwuwa a rage haɗarin cututtukan zuciya da kashi ɗaya bisa uku.

Metformin ba ya haifar da ci gaban hypoglycemia lokacin da aka dauki shi daidai. An lura da shi a cikin lokuta masu wuya tare da ƙoƙarin motsa jiki ko amfani da miyagun ƙwayoyi tare da wasu wakilai na hypoglycemic. A cikin marasa lafiya masu lafiya, ba ya rage glucose.

Jikin tsufa

Kamar yadda aka ambata a sama, Elena Malysheva ta ce a cikin shirinta cewa Metformin yana hana tsufa. Ta kuma yi magana game da yiwuwar tsawaita cikakken rayuwa mai inganci. Yanzu cikin ƙarin daki-daki game da bayanin.

“Tsufa daga cikin kwayoyin” kwatanci ne a zahiri. Yana nufin tsufa wanda cuta ta haifar. A takaice dai, wannan shine yanayin ilimin halittar jiki, wanda bai dace da alamar a cikin fasfo din ba.

A kan shirin "Live Healthy" an sanya wani tsari a cikin nau'ikan sikeli na lantarki, wanda ke auna shekarun nazarin halittu.

Gaskiyar irin wannan tsufa shine ƙara girman matakan glucose a cikin jini. A sakamakon haka, sunadarai suna da ƙoshin lafiya (wannan ya haɗa da sunadaran fata), wanda ke haifar da haifar da alaƙar wrinkles. Fasa a cikin tasoshin a ƙarƙashin rinjayar sukari.

Daga kwayar glucose ta 1, ana samun 2 triglyceride kwayoyin, i.e. mai. Fats sun haɗu a cikin fasa, suna samar da abubuwan da ake kira filayen atherosclerotic. An tsara magungunan don dakatar da waɗannan hanyoyin da ke faruwa a cikin tasoshin.

Duk cikin karni na 20, an gudanar da binciken magunguna daban-daban. A karshen shekarar 2015, an kammala binciken kimiyya (na tsawon shekaru 25) na Metformin a jami’ar Ingila.

Mahalarta binciken sun kasance mutane masu fama da cutar siga mai nau'in 2. A cewar kintace, suna da shekaru 8 ne kawai su rayu. Amma ba wanda ya mutu a lokacin gwajin. Sun kammala cewa maganin kai tsaye yana tura farkon mutuwa da tsufa.

Bidiyo tare da ra'ayin Dr. Malysheva game da Metformin:

Tasiri kan nauyin jiki

Metformin baya shafar ƙimar nauyi idan aka kwatanta da sulfonylureas. Akasin haka, ana amfani dashi a cikin ƙwaƙƙwarar magani don kiba. An gano cewa maganin yana rage yawan kitse.

Mutanen da ke da ƙoshin lafiya tare da matakan sukari na al'ada waɗanda suke so su rasa nauyi na iya ɗaukar magani. Yawan cin abinci na yau da kullun yana kawar da matsakaicin kilogiram 2.5-3 kuma yana rage adadin abincin da ake ci. A cikin mutum mai lafiya, ƙwayar ba ta rage matakan sukari, saboda haka ana iya amfani dashi a allurai matsakaici.

Shirin Malysheva ya ce Metformin don asarar nauyi yana da tasiri.

Aikace-aikacen ƙwayar ƙwayar polycystic

Metformin magani ne mai taimako wanda ana amfani dashi a cikin hadadden magani na rashin haihuwa. Wasu masana sun ba da shawarar amfani da shi azaman magungunan farko, wasu a matsayin layi na biyu.

Yana karfafa kwai kuma yana taimaka wa mace ta sami juna biyu. Kuma kamar yadda kuka sani, polycystic ovary shine ilimin cututtukan endocrinological wanda ke haifar da rasa haihuwa. Matar tana da juriya ta insulin.

Saboda haka, Metformin yana da matukar mahimmanci a lura da wannan cuta. An wajabta shi a cikin tsari tare da kwayoyin ba da sauran kwayoyi.

Side effects

Tare da duk halaye masu kyau na miyagun ƙwayoyi, bai kamata ku tafi cikin kantin magani nan da nan ba. Ana ɗaukar shi don dalilai na likita kuma kamar yadda likita ya umarta. Da farko dai, yana da mahimmanci a fahimci cewa Metformin magani ne. Kuma kowane magani, kamar yadda ka sani, yana haifar da sakamako masu illa.

Yawancin raunin da ya fi faruwa ana bayyana su ta hanji. Rashin ruwa yana farawa, ɗanɗano mai ƙarfe yana bayyana a bakin, damuwa mai ɓacin rai. Magungunan na iya tsoma baki tare da ɗaukar B12, wanda ke haifar da daidaituwa da ƙuƙwalwa.

Sakamakon abu mai sauƙi amma mai muni na amfani da sarrafawa ba tare da izini ba na Metformin shine lactic acidosis, shari'ar guda yana faruwa a 10 dubu.

Koyaya, dole ne a yi taka tsantsan:

• an yarda da ƙayyadaddun kodan lafiya tare da ingantaccen aikin ƙirar dunƙule,
• ba'a sanya wa tsoffin tsofaffi ba
• Yakamata ya kasance cikin matakan halitta
• tare da kowane asibiti, an dakatar da liyafar, musamman tare da karatun x-ray.

Metformin yana da fa'idodi da yawa a cikin maganin warkewa, amma ba cikakkiyar panacea ba ce. Ana ɗaukar shi kamar yadda likita ya umarta kuma saboda dalilai na likita. Amma idan mutum ya kamu da cutar sankara, shan maganin yana da kyau kuma yana da fa'ida.

Metformin: tushen aiki

Babban nuni ga amfani da miyagun ƙwayoyi, kamar yadda aka ambata a sama, shine ciwon sukari. Ta hanyar yin amfani da irin wannan magani, yana jujjuya ba kawai don rage matakin sukari ba, har ma don jimre da alamun bayyanar kiba. Saboda wannan fasalin, ana bada shawarar metformin sau da yawa don asarar nauyi. Ana samun sakamako mai santsi saboda gaskiyar cewa metformin yana aiki kamar haka:

• Yana rage gudu aiki da carbohydrates, musamman masu sauki,
• yana ɗeukar kamshi a cikin abinci baki ɗaya,
• yana rage cin abinci ta hanyar toshe hanyoyin samuwar insulin.

Metformin bashi da ƙone kitsen mai. Amma amfani da mu yana ba mu damar samar da irin wannan yanayi inda kawar da fatyyen da ake ciki zai zama aiki mai sauƙi. Kuma wannan abu ne na halitta, tunda wannan magani kusan analogue ne na metformin mai sauƙi.

Koyaya, yana da mahimmanci a gano ra'ayin masana game da amfani da irin wannan ƙwayar cuta, kuma a lokaci guda duba yadda yake aiki a aikace. Daga cikin sanannun ƙwararrun ƙwararrun, watakila mafi mashahuri a tsakanin talakawa shine Elena Malysheva.Saboda haka, ra'ayinta ya cancanci da farko idan aka yi la'akari da sake duba irin wannan kayan aiki.

Ra'ayin Malysheva game da metformin

A cikin sanannun sanannun kuma sanannen shirin "Ku rayu lafiya!" Da yawa rez sunyi magana game da metformin. Haka kuma, saboda mafi yawan bangare, ba'a dauki shi azaman hanyar rasa nauyi ba. Bayan haka, babban dalilin maganin shine a sauƙaƙa rayuwa ga marasa lafiya da masu ciwon sukari. Sabili da haka, sake dubawa Malysheva ya danganta da tasirin warkewarsa. Anan zaka iya lura da irin waɗannan mahimman abubuwan da ke hade da magani.

1. Kamar yadda likita ya jaddada, metformin wata hanya ce ta daidaituwa metabolism na metabolism. Wannan yana nufin cewa, da farko, dole ne mutanen da ke da matsala masu rikicewa su ɗauke shi. A lokaci guda, Malysheva ya ba da shawarar yin amfani da metformin a cikin adadin da ya dace ga duk wanda yake so ya tsawanta matasa, saboda yadda ya dace da sinadarin carbohydrates na taimaka wajan tsawan lafiya.
2. Malysheva baya cire yiwuwar yin amfani da metformin don asarar nauyi. Amma dole ne a samar da abubuwan da suka dace domin wannan. Idan akwai cin zarafi a cikin samar da insulin, to shan shan magani ya zama barata. Gaskiya ne, likita ya kamata ya kula da maganin. Don haka, kwararren ba ya kira metformin wata hanyar da za a cire karin fam, duk da cewa amfanin sa bai musanta hakan ba.

Shin zai yuwu a sami tabbaci na amfanin wannan kayan aikin a aikace? Don fahimtar yadda tasirin maganin yake, yana da kyau a duba sake dubawar mutanen da suka sha shi. Yanzu ana iya samun sake dubawa game da rasa nauyi a adadi mai yawa. Abin baƙin ciki, da nisa daga kullun magana kawai game da rasa nauyi. Wasu lokuta akwai nassoshi game da haɗarin samfurin.

Metformin: sake dubawa game da rasa nauyi da asarar nauyi

"Yana rage sukari kuma yana kawar da kilo kilogram"

Sakamakon karuwar sukari da haɗarin ciwon sukari, an umurce ni in sha metformin. Kafin ɗaukar wannan kayan aiki, Na yanke shawarar bincika sake dubawa da aka bari a kansa don in wakilci daidai da abin da zan yi maganin su. Binciken ya yi magana game da damar da miyagun ƙwayoyi har ma da rasa nauyi. An sanya mani allurar kadan ne, don haka yayin liyafar ba ban lura da wani abin mamaki ba. Amma sukari, hakika, ya ragu. Kuma a cikin wata daya da rabi, yayin da nake shan magungunan, nauyina ya ragu da kilogiram 3. Amma ban sani ba ko wannan maganin zai taimaka wa waɗanda suka fara samun komai a cikin tsari tare da sukari.

"A tare tare da aikin abinci"

Ban taɓa ƙoƙarin rasa nauyi ba kawai tare da taimakon magungunan ƙwayoyi ko wani irin kayan abinci. Amma, lokacin da na sake ci gaba da cin abinci, sai na yanke shawarar kara wani “tallafi” a ciki. A cikin rawar irin wannan tallafin, Na zabi kawai metformin. Kamar dai yarda da sake dubawa, wanda a zahiri yake alfahari da duk launuka. Ita da kanta ta lura cewa ba duk abu bane mai sauki da wannan maganin. Da farko, ba ta ji daɗi sosai - ba ta da lafiya har ma da amai. Sannan ya sami sauki. Tsawon watanni 2, lokacin da ta iyakance kanta cikin abinci kuma ta dauki metformin, asarar ta kusan kilo 7. Ina ji sakamakon yana da kyau. Don haka, gwada kuma kuna rasa nauyi a daidai wannan hanyar. A ganina tabbas zai taimaka.

"Asarar nauyi akan metformin bayan haihuwa"

Labari na daidaitacce - bayan haihuwar jariri ya cika cika sosai fiye da da. Da farko, ba ta sanya da yawa da hankali ga wannan ba. Ina fatan cewa abinda ya wuce yadda yakamata zai bace. Amma ba - a kan lokaci, Na ma ci fiye da ƙari. Yawancin yakai kilo 10. Na tambayi likita na ko akwai magani mai inganci wanda zai taimaka wajen kawar dasu. Ya shawarci metformin. Tabbas, a cikin 'yan watanni biyu ya zama ya dawo da kyau. Gaskiya ne, ni ma na bi tsarin karancin carb, don haka sakamakon ba abin mamaki bane.

"Inganci ne, amma akwai sakamako masu illa"

Yawancin lokaci ina shan metformin lokacin da ya zama dole in rasa nauyi ba tare da ƙoƙari mai yawa ba. Kuma shi, bisa manufa, koyaushe yana taimaka mini. Matsala ɗaya kawai - a lokacin gudanarwarsa, matsaloli tare da hanji suna bayyana: wani lokacin maƙarƙashiya, wani lokacin, nadama, zawo. Wannan sakamakon yana da ban tsoro sosai, amma ni ma na saba da shi. Babban abu shine samfurin yana aiki kuma baya haifar da mummunar illa. Sabili da haka, a gaba in ku ma kuna son rasa nauyi, tuna da irin waɗannan kwayoyin magani. Zai yiwu cewa zasu dace da ku sosai kuma suna taimakawa rage nauyi.