Dakatarwa ga yara Amoxiclav 125 MG: umarnin don amfani

Allunan da aka rufe fim din 500 MG / 125 MG, 875 MG / 125 MG

Tabletaya daga cikin kwamfutar hannu mai rufe jiki

abubuwa masu aiki: amoxicillin (as amoxicillin trihydrate) 500 MG da clavulanic acid (as potassium clavulanate) 125 MG (don sashi 500 mg / 125 mg) ko amoxicillin (as amoxicillin trihydrate) 875 mg da acid na clavulanic (as potassium clavulanate) 125 mg (don sashi na 875 mg / 125 mg).

magabata: colloidal silicon dioxide, crospovidone anhydrous, sodium carboxymethyl cellulose, magnesium stearate, bushe microcrystalline cellulose.

fim ɗin abun da ke ciki na fim: hydroxypropyl cellulose, ethyl cellulose, polysorbate, triethyl citrate, titanium dioxide (E 171), talc.

Allunan an lullube su da zanen fim na farin fari ko kusan fararen launi, a tsaye, tare da fatar baki, aka zana shi da "875/125" da alama a gefe guda, kuma aka zana shi tare da "AMS" a gefe guda (don sashi na 875 mg / 125 mg).

Facungiyar makamai

Magungunan ƙwayoyin cuta don amfani da tsari. Magungunan antibacterial Beta-lactam - Penicillins. Penicillins a hade tare da hanawar beta-lactamase. Clavulanic acid + amoxicillin.

Lambar ATX J01CR02

Kayan magunguna

Pharmacokinetics

Amoxicillin da clavulanic acid an narkar da su gaba daya a cikin wani bayani mai ruwa-ruwa a dabi'un pH na jiki. Duk abubuwan biyu suna haɗuwa sosai bayan gudanarwar baka. Zai fi kyau a sha amoxicillin / clavulanic acid a lokacin ko a farkon cin abinci. Bayan gudanar da baki, bioavailability na amoxicillin da clavulanic acid shine kusan 70%. Thearfafawa na ƙwayar ƙwayar cuta a cikin ƙwayar plasma duka abubuwan biyu sunyi kama. Ana samun mafi girman yawan ƙwayoyin magani 1 awa bayan gudanarwa.

Maganin tarawa na amoxicillin da clavulanic acid lokacin shan hadewar amoxicillin / clavulanic acid sun yi kama da wadanda aka lura tare da gudanar da wani nau'in maganin baka na daidai gwargwado na amoxicillin da clavulanic acid.

Kimanin 25% na adadin acid na clavulanic acid da kashi 18% na amoxicillin suna daure ne da kariyar plasma. Ofarar da rarrabawa don gudanar da maganin baka na maganin shine kusan 0.3-0.4 l / kilogiram na amoxicillin da 0.2 l / kilogiram na clavulanic acid.

Bayan gudanarwa na jijiyoyin ciki, an sami amoxicillin da clavulanic acid a cikin ƙwayar ciki, ƙyallen ƙwayar ciki, fata, kitse, ƙwayar tsoka, ƙwayar jijiyoyin ciki da na ciki. Amoxicillin ya shiga cikin rashi a cikin mahaifa.

Amoxicillin da acid na clavulanic sun ƙetare shinge na jini. Dukkan abubuwan guda biyu kuma suna shiga cikin madarar nono.

An cire wani abu mai narkewa a cikin fitsari a cikin sinadarin Penicillic acid wanda yake daidai da kashi 10-25% na kashi na farko. Clavulanic acid yana metabolized a cikin jiki kuma an keɓe shi a cikin fitsari da feces, haka kuma a cikin carbon dioxide tare da iska mai ƙuna.

Matsakaicin rabin rabin amoxicillin / clavulanic acid shine kimanin awa 1, kuma matsakaiciyar cirewa kusan 25 l / h. Kimanin 60-70% na amoxicillin da 40-65% na clavulanic acid an keɓance su cikin fitsari a cikin awanni 6 na farko bayan ɗaukar kashi ɗaya na allunan amoxicillin / clavulanic acid. A yayin bincike daban-daban, an gano cewa kashi 50-85% na amoxicillin da kuma 27-60% na clavulanic acid an kebe su a cikin fitsari a cikin awanni 24. Mafi yawan adadin acid ɗin clavulanic an keɓance shi a cikin farkon 2 hours bayan aikace-aikace.

Yin amfani da probenecid a lokaci guda yana rage jinkirin amoxicillin, amma wannan magani ba ya shafar tasirin ƙwayoyin clavulanic ta hanjin kodan.

Rabin rayuwar amoxicillin yayi daidai da a cikin yara masu shekaru 3 zuwa 2 years, kuma a cikin manyan yara da manya. Lokacin da aka rubuta magunguna ga yara ƙanana (har da ƙananan yara) a farkon makonni na rayuwa, bai kamata a gudanar da maganin fiye da sau biyu a rana ba, wanda ke da alaƙa da rashin ingancin hanya na yara na yara a cikin yara. Saboda gaskiyar cewa tsofaffi marasa lafiya sun fi wahala daga tabarbarewa na yara, ya kamata a yi amfani da Amoxiclav 2X tare da taka tsantsan a wannan rukunin marasa lafiya, amma ya kamata a sa ido kan aikin na koda idan ya cancanta.

Adadin jimlar amoxicillin / clavulanic acid a cikin plasma yana raguwa daidai gwargwado zuwa raguwa a aikin renal. Rage bayanin amoxicillin an bayyana shi sosai idan aka kwatanta da acid ɗin clavulanic, tunda ana fitar da adadin amoxicillin ta hanjin kodan. Sabili da haka, lokacin da ake tsara magunguna ga marasa lafiya da gazawar renal, daidaitawa kashi yana da mahimmanci don hana tara yawan amoleraillin da kuma kula da matakin da ake buƙata na clavulanic acid.

Lokacin ƙirƙirar ƙwayar magunguna ga marasa lafiya da gazawar hanta, ya kamata a yi taka tsantsan lokacin zabar wani kashi kuma kula da aikin hanta a kai a kai.

Pharmacodynamics

Amoxicillin shine kwayoyin rigakafi daga kwayar penicillin (maganin beta-lactam) wanda ke hana enzymes guda ɗaya ko fiye (wanda ake magana dashi azaman sunadarin penicillin-dauri) wanda ke cikin biosynthesis na peptidoglycan, wanda shine mahimman tsarin tsarin bangon ƙwayar cuta. Haramcin peptidoglycan kira yana haifar da raunana bangon tantanin halitta, yawanci ana biye da shi ta hanyar tantanin halitta da mutuwar tantanin halitta.

An lalata Amoxicillin ta hanyar beta-lactamases wanda kwayoyin cuta masu jurewa, kuma, sabili da haka, wasan kwaikwayon na amoxicillin kadai ba ya haɗa da ƙwayoyin halitta waɗanda ke samar da waɗannan enzymes.

Clavulanic acid shine beta-lactam wanda aka haɗa shi da penicillins. Yana hana wasu abubuwan beta-lactamases, don haka hana inacor na amoxicillin, da kuma fadada aikinsa. Clavulanic acid kansa bashi da tasirin ƙwayar cuta mai ƙwayar cuta.

Lokaci mai wucewa da mafi ƙarancin maida hankali (T> IPC) ana ɗauka shine babban ƙuduri na ingancin amoxicillin.

Hanyoyi biyu na tsayayya da amoxicillin da clavulanic acid sune:

inactivation by beta-lactamases na kwayan cuta wanda sinadarin clavulanic acid bai hana shi ba, gami da azuzuwan B, C da D.

wani canji a cikin sunadarai masu penicillin, wanda ke rage alakar antibacterial wakili a cikin kwayar cutar.

Rashin ingancin ƙwayoyin cuta ko hanyoyin da famfol efflux (tsarin jigilar kwayoyi) zasu iya haifar ko kula da juriya daga ƙwayoyin cuta, musamman ƙwayoyin cuta marasa kyau.

Limita'idodin iyakance na MIC don amoxicillin / clavulanic acid sune waɗanda Kwamitin Turai ya ƙaddara don Gwajin Saurin Antimicrobial Sensitivity (EUCAST).

Hanyar aikin

Amoxicillin shine kwaro-kwalayen kwalayen kwalayen kwayoyi masu motsa jiki tare da aiki da yawa da kwayoyin cuta na gram-tabbatacce kuma na gram-korau. A lokaci guda, amoxicillin yana da saukin kamuwa da lalacewa ta hanyar beta-lactamases, sabili da haka bakan aikin amoxicillin baya yaduwa ga ƙananan ƙwayoyin halittar da suke samar da wannan enzyme.

Clavulanic acid, wani sinadarin beta-lactamase inhibitor wanda ya shafi penicillins, yana da ikon hana nau'ikan beta-lactamases da aka samo a cikin maganin penicillin da cephalosporin mai jure kwayoyin. Clavulanic acid yana da isasshen inganci ga maganin plasmid beta-lactamases, waɗanda suka fi dacewa da juriya na kwayar cuta, kuma ba shi da tasiri a kan nau'in chromosome beta-lactamases, wanda acid ɗin ba su hana shi ba.

Kasancewar acid na clavulanic a cikin shirye-shiryen yana kare amoxicillin daga lalacewa ta hanyar enzymes - beta-lactamases, wanda ke ba da damar fadada ƙwayoyin ƙwayoyin cuta na amoxicillin.

Amoxiclav yana da aikin kashe ƙwayoyin cuta zuwa ƙananan ƙwayoyin cuta:

• Anarambes na gwaje-gwaje na Gram-tabbatacce (Staphylococcus aureus, pneumococcus, pyogenic streptococcus, sauran nau'in staphylococcus aureus da streptococcus, clostridia, peptococcus),
• Anaerobes na Gram-korau (kwayoyin kwaro na Kolya, kwayoyin halittar jikin Enterobacter, Klebsiella, Moraxella cataralis, Bordetella, Salmonella, Shigella, kwalara Vibrio).

Saboda gaskiyar cewa wasu nau'ikan ƙwayoyin cuta na sama suna samar da beta-lactamase, wannan yana sa su zama masu rashin hankali ga Amoxicillin monotherapy.

Pharmacokinetics

Dukkanin abubuwan aiki guda biyu suna nutsuwa sosai, ba tare da la'akari da yawan abincin ba. Matsakaicin ƙwayar plasma an kai shi sa'a daya bayan ɗaukar magani (Cmax don amoxicillin - 3-12 μg / ml, Cmax don clavulanic acid - 2 μg / ml.

Abubuwan da ke tattare da ƙwayoyin cuta na Amoxiclav suna da kyau a cikin abubuwan jin daɗi, parietal, ruwa mai narkewa, ƙoshin hanji, ƙwanƙwasa hanci, ƙwanƙwasa, da kuma a cikin ƙoshin jikin mutum (a cikin huhu, ƙwanƙwalin palatine, kunne na tsakiya, ƙwayoyin mahaifa, mahaifa, hanta, ƙwanƙwasa hanji, ƙwayar tsoka, ƙwayar ciki ) Magungunan ba zai iya shiga cikin katangar-kwakwalwa ba (tare da ragwancin mara amfani). Har ilayau, ta hanyar shinge ta cikin mahaifa, a cikin abubuwan da aka gano sun fashe tare da madarar nono. Yana ɗaure da ƙarfi ga furotin na plasma, amoxicillin trihydrate partially bazuwar, clavulanic acid - gaba daya.

Thewayoyin ta kwantar da ƙwayoyin cutar ta kusan canzawa. Amountsarancin abu yana shafan huhu kuma ta cikin hanji. Rabin rayuwar shine 1-1.5 hours.

Amoxicillin an cire shi da kodan kusan ba a canza shi ta hanyar tubular ɓoyewa da kuma ruɗar murfin ƙasa. Ana iya fitar da ƙananan adadi ta hanji da huhu. T1 / 2 na amoxicillin da clavulanic acid shine 1-1.5 hours. A cikin gazawar ƙwayar koda, yana ƙaruwa don amoxicillin har zuwa 7.5 hours, don clavulanic acid - har zuwa 4,5 hours. An cire dukkanin abubuwan haɗin biyu yayin hemodialysis.

Alamu don amfani

Amoxiclav magani ne na kwayan cuta, an nuna shi ne don magance cututtukan cututtukan da ke haifar da kwayoyin cutar penicillin da maganin ta:

• kamuwa da cuta na babba na numfashi da gabobin ENT (muguwar ƙwaƙwalwa da ciwan mara nauyi, matsanancin ƙwaƙwalwar ƙwayar otitis, ƙwayar jijiyoyin ƙwayar cuta, ƙwanƙwasa hanji, ƙwayar cuta),
• ƙananan ƙwayar jijiyoyin ƙwayar cuta (mashako mai ciki tare da superinfection na kwayan cuta, mashako na kullum, ciwon huhu),
• cututtukan urinary fili (misali, cystitis, urethritis, pyelonephritis),
• cututtuka a cikin ilimin ilimin mahaifa,
• cututtukan fata da fata na laushi, gami da dabbobi da ciwan mutum,
• kashi da kuma haɗin nama,
• cututtukan biliary fili (cholecystitis, cholangitis),
• odontogenic cututtuka.

Sashi da gudanarwa

A ciki. An saita tsarin sashi daban-daban gwargwadon shekarun, nauyin jikin mutum, aikin ƙodan mai haƙuri da tsananin kamuwa da cuta.

Matsakaicin kullun na dakatarwa shine 125 MG + 31.25 MG (don sauƙaƙe suturar da ta dace, ƙwararrun 5 mai digiri na digiri tare da sikelin 0.1 ml ko cokali 5 na sashi tare da alamar kowace shekara a cikin ƙwayar 2.5 ml a cikin kowane kunshin. da 5 ml).

Hotunan 3D

Bayanin sigar sashi

Allunan 250 + 125 mg: fararen fata ne ko kuma fararen fata ne, mai shugannin bakin teku, octagonal, biconvex, mai dauke da fim, tare da kwafin “250/125” a gefe guda da “AMC” a daya gefen.

Allunan kwayoyi 500 + 125: fari ko kusan fararen fata, m, biconvex, fim mai rufi.

Allunan 875 + 125 mg: fararen fata ne ko kuma fararen fata ne, masu dumu-dumu, biconvex, fim mai rufi, tare da abubuwan lura da abubuwan ban sha'awa “875” da “125” a gefe guda kuma “AMC” a daya gefen.

Duba kan wani kink: taro mai launin shuɗi.

Foda don dakatarwa don gudanarwa na baka: foda daga fari zuwa fari fari. Dakatarwar da aka gama shine fitowar masu kama da juna daga kusan fari zuwa rawaya.

Foda don shiri don samar da mafita ga gwamnatin iv: daga fari zuwa fari mai launin shuɗi.

Allunan da ba za a iya raba su ba: oblong, octagonal, rawaya mai haske tare da dunƙule launin ruwan kasa, tare da ƙamshi mai ɗanɗano.

Pharmacodynamics

Amoxiclav ® hade ne da amoxicillin da acid na clavulanic.

Amoxicillin shine kwayar penicillin penisilinin semisynthetic (maganin beta-lactam) wanda ke hana daya ko fiye da enzymes (wanda ake alakanta shi azaman penicillin-da ke ɗaure garkuwar jiki, PSB) a cikin biosynthesis na peptidoglycan, wanda shine babban tsarin tsarin bangon ƙwayar cuta. Hibarfin kira na peptidoglycan yana haifar da asarar ƙarfin bango na sel, wanda yawanci yana haifar da lysis da mutuwar ƙwayoyin microorganism.

An lalata Amoxicillin ta hanyar aikin beta-lactamases wanda kwayoyin cuta masu jurewa, don haka ƙwaƙwalwar motsi na amoxicillin bai ƙunshi ƙwayoyin cuta ba waɗanda ke samar da waɗannan enzymes.

Clavulanic acid shine beta-lactam wanda aka haɗa shi da penicillins. Yana hana wasu sinadarai na beta-lactamases, don haka hana inacor na amoxicillin da fadada kwayar aikinta, gami da kwayoyin cuta wadanda yawanci suna maganin amoxicillin, harma da sauran penicillins da cephalosporins. Clavulanic acid kansa bashi da tasirin ƙwayar cuta mai ƙwayar cuta.

Amoxiclav ® yana da tasirin ƙwayar cuta a cikin vivo ga wadannan kananan kwayoyin:

- gram-tabbatattun jiragen sama - Staphylococcus aureus *, ciwon huda na huhun ciki, Kwayoyin cuta mai tsoratarwa,

- gram korau iska - Enterobacter spp. **, Escherichia coli *, Haemophilus mura *nau'in kwayoyin halittar Klebsiella *, Moraxella catarrhalis * (Branhamella catarrhalis).

Amoxiclav ® yana da tasirin ƙwayar cuta a cikin vitro akan wadannan kananan kwayoyin (kodayake, har yanzu ba'a san mahimmancin asibitin ba):

- gram-tabbatattun jiragen sama - Bacillis anthracis *nau'in kwayoyin halittar Corynebacterium, Enterococcus faecalis *, Enterococcus faecium *, Listeria monocytogenes, Nocardia asteroidescoagulase-korau staphylococci * (hade da Abubuwan da ke fama da kwayoyin cutar 'staphylococcus epidermidis'), Alawarfafawar ƙwaƙwalwa, sauran nau'ikan halittar Ptoawancen ƙarfi, budurwai mara ƙarfi,

- gram-tabbatacce anaerobes - jinsunan halittar Clostridiumnau'in kwayoyin halittar Kankananau'in kwayoyin halittar Karatocin,

- gram korau iska - Bordetella pertussisnau'in kwayoyin halittar Brucella, Gardnerella vaginalis, Helicobacter pylorinau'in kwayoyin halittar Legionella, Neisseria gonorrhoeae *, Neisseria meningitidis *, Pasteurella multocida, Proteus mirabilis *, Proteus vulgaris *nau'in kwayoyin halittar Salmonella *nau'in kwayoyin halittar Shigella *, Vibrio cholerae, Yersinia enterocolitica *,

- gram-korau anaerobes - jinsunan halittar Bacteroides * (gami da Bacteroides fragilis), nau'in kwayar halittar Fusobacterium *,

- wasu - Borrelia burgdorferi, Chlamydia spp., Leptospira icterohaemorrhagiae, Treponema pallidum.

* Wasu nau'ikan nau'ikan ƙwayoyin cuta suna samar da beta-lactamases, wanda ke ba da gudummawa ga rashin hankalin su ga amoxicillin monotherapy.

** Yawancin nau'ikan waɗannan ƙwayoyin cuta suna da tsayayya da haɗuwa da amoxicillin / clavulanic acid a cikin vitro , duk da haka, ingancin asibiti na wannan haɗuwa an nuna shi cikin lura da cututtukan urinary fili da ke haifar da waɗannan lamuran.

Alamu na nuni da Amoxiclav ®

Ga dukkan siffofin sashi

Cututtukan da ke haifar da cututtukan ƙwayoyin cuta mai lalacewa:

babba na numfashi da gabobin ENT (gami da cututtukan cututtukan ƙwayar cuta da na kullum, matsananciyar ƙwayar otitis media, ƙonewar ƙwayar jijiyoyin ƙwayar cuta, ƙwaƙwalwar ƙwayar cuta, ƙwaƙwalwar hanji),

ƙananan ƙwayar na numfashi (ciki har da babban mashako tare da superinfection ƙwayar cuta, mashako na kullum, ciwon huhu),

urinary fili (misali cystitis, urethritis, pyelonephritis),

fata da taushi kyallen takarda, gami da cizon mutane da dabbobi,

kashi da nama mai hadewa

bile sauro (cholecystitis, cholangitis),

Don foda don shiri na mafita don gudanar da iv

cututtukan ciki

cututtukan da ake kamuwa da ita ta hanyar jima'i (goriya, m sauƙin),

rigakafin kamuwa da cuta bayan tiyata.

Contraindications

rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi,

hypersensitivity ga penicillins, cephalosporins da sauran maganin rigakafin beta-lactam a cikin anamnesis,

wani tarihin cutar cholestatic jaundice da / ko wani dysfunction hanta wanda ya haifar da gudanarwar amoxicillin / clavulanic acid,

na ciwon maɗamfari mononucleosis da cutar kuturta,

Don allunan da aka baza amo Amolalav ® Quicktab bugu da ƙari

yara 'yan kasa da shekara 12 ko yin nauyin kilo 40.

gazawar koda (Cl creatinine, ƙwayar jijiyoyin zuciya, gazawar hanta, tabarbarewa na koda, ciki, lactation, amfani da lokaci daya tare da maganin rashin nasara).

Haihuwa da lactation

Yayin cikin ciki da kuma lokacin shayarwa, ana amfani da Amoxiclav only ne kawai idan amfanin da aka tsammaci zai yiwa mahaifiyar fiye da girman hadarin da tayi ga jaririn da jariri.

Ana iya ba da umarnin Amoxiclav ® Quicktab yayin daukar ciki idan akwai alamun bayyananniya.

Amoxicillin da acid na clavulanic a cikin adadi kaɗan sun shiga cikin nono.

Side effects

Allunan da aka hada da fim din Amoxiclav and da kuma foda don shirye-shiryen mafita don gudanar da iv

Daga tsarin narkewa: asarar ci, tashin zuciya, amai, gudawa, zawo, ciki, jin ciki, stomatitis, glossitis, black “mai gashi” harshe, duhu mai ƙoshin enamel, basur mai ɗauke da cuta (na iya haɓaka bayan farji), enterocolitis, pseudomembranous colitis, rashin aiki hanta, ƙaruwar aiki ALT, AST, alkaline phosphatase da / ko matakan bilirubin plasma, gazawar hanta (mafi yawan lokuta a cikin tsofaffi, maza, tare da tsawan magani), cholestatic jaundice, hepatitis.

Allergic halayen: pruritus, urticaria, erythematous rashes, erythema multiforme exudative, angioedema, anaphylactic shock, rashin lafiyan vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, m na jigilar exanthematous pustulosis, ciwo mai kama da cutar sankara, cututtukan ƙwayar cuta mai guba.

Daga tsarin cutar haemopoietic da lymphatic system: leukopenia mai rikicewa (ciki har da neutropenia), thrombocytopenia, hemolytic anemia, zazzagewar sakewa a cikin PV (lokacin da aka yi amfani dashi tare da cututtukan anticoagulants), farfadowa mai canzawa a lokacin zubar jini, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

Daga gefen tsarin juyayi na tsakiya: amai, ciwon kai, rashi (na iya faruwa a cikin marassa lafiya da ke fama da rauni game da aiki lokacin shan magunguna).

Daga tsarin urinary: interstitial nephritis, crystalluria, hematuria.

Sauran: candidiasis da sauran nau'ikan superinfection.

Don allunan da aka saka a fim, foda don dakatarwa na baka, foda don maganin maganin ƙari

Daga gefen tsarin juyayi na tsakiya: rashin ƙarfi. Jin damuwa, rashin bacci, canjin hali, tashin hankali.

Amoxiclav ® Quicktab da Amoxiclav ® foda don dakatarwar baka

Daga gabobin hemopoietic da tsarin lymphatic: da wuya - ana iya jujjuya leukopenia (gami da neutropenia), thrombocytopenia, da wuya - eosinophilia, thrombocytosis, farfadowa agranulocytosis, karuwa a lokacin zubar jini da karuwa wanda zai iya canzawa a cikin PV, anemia, gami da wanda ke iya juyawa da cutar hauka.

Daga tsarin rigakafi: ba a san tazarar ba - angioedema, halayen anaphylactic, rashin lafiyan vasculitis, wata cuta mai kama da cutar sankara.

Daga tsarin juyayi: infrequently - tsananin kishi, ciwon kai, da wuya - rashin bacci, tashin hankali, damuwa, canjin hali, jujjuyawar yanayi, tashin zuciya, rashi na iya faruwa a cikin marassa lafiyar da ke fama da matsalar aiki, kamar yadda kuma a cikin wadanda ke karbar magungunan.

Daga cikin jijiyoyin mahaifa: sau da yawa - asarar ci, tashin zuciya, amai, zawo. Ana samun yawan cutar tashin zuciya a lokacin da ake yawan allura mai yawa. Idan an tabbatar da cututtukan gastrointestinal, za'a iya kawar dasu idan an sha maganin a farkon cin abinci, a lokaci-lokaci - narkewar haushi, da wuya ƙwayar cuta ke haɗuwa da ƙwayar cuta ta hanyar ƙwayoyin cuta (ciki har da pseudomembranous da basur na cuta), baki mai gashi, glandon ciki stomatitis. A cikin yara, ba za a taɓa gano ƙasan farfaɗar rufin farfaɗar ƙoshin hakori ba. Kulawar baki yana taimakawa hana fashewar hakorin hakori.

A bangare na fata: infrequently - fatar fata, itching, urticaria, da wuya - multiforme exudative erythema, ba a sani ba mita - Stevens-Johnson ciwo, mai guba epidermal necrolysis, bullous exfoliative dermatitis, m janar exanthematous pustulosis.

Daga tsarin urinary: da wuya sosai - crystalluria, interstitial nephritis, hematuria.

A ɓangaren hanta da ƙwayar biliary: akai-akai - ƙara yawan aiki na ALT da / ko AST (ana lura da wannan sabon abu a cikin marasa lafiya da ke karɓar maganin rigakafi na beta-lactam, amma ba a san mahimmancinsa na asibiti ba), An lura da abubuwan da suka faru daga hanta musamman a cikin maza da tsofaffi marasa lafiya kuma ana iya haɗa su. tare da magani na dogon lokaci. Ba a taɓa ganin irin waɗannan lamuran a cikin yara ba.

Alamun da alamomin da aka lissafa yawanci suna faruwa ne a lokacin ko kuma kai tsaye bayan ƙarshen maganin, duk da haka a wasu halaye waɗanda ba za su iya bayyana ba a cikin makonni da yawa bayan kammala maganin. Mummunan abubuwa yawanci ana jujjuya su. Mummunan al'amuran daga hanta na iya zama mai wahala, a cikin mawuyacin halaye akwai rahotannin sakamako mai ƙarewa. A kusan dukkanin lokuta, waɗannan sun kasance marasa lafiya tare da babban haɗarin haɗari ko marasa lafiya da ke karɓar magungunan cutar hepatotoxic masu haɗari. Da wuya sosai - ƙara yawan ayyukan alkaline phosphatase, ƙara yawan bilirubin, hepatitis, cholestatic jaundice (an lura dashi tare da maganin kwantar da hankali tare da sauran maganin penicillins da cephalosporins).

Sauran: sau da yawa - candidiasis na fata da ƙwayoyin mucous, ba a san mita ba - haɓakar ƙwayoyin ƙwayoyin cuta.

Haɗa kai

Ga dukkan siffofin sashi

Antacids, glucosamine, laxatives, aminoglycosides rage jinkirin sha, ascorbic acid yana ƙaruwa sha.

Diuretics, allopurinol, phenylbutazone, NSAIDs da wasu kwayoyi suna toshe tubular secretion (probenecid) suna kara yawan amoxicillin (clavulanic acid an ware su musamman ta hanyar lalata duniyan).

Yin amfani da Amoxiclav ® da methotrexate lokaci guda yana ƙara yawan guba na methotrexate.

Alƙawarin tare da allopurinol yana ƙaruwar haɗarin exanthema. Ya kamata a guji amfani da mai amfani da discofiram tare da disulfiram

Yana rage tasiri na kwayoyi, yayin metabolism wanda aka kirkiro PABA, ethinyl estradiol - haɗarin zubar jini.

Littattafan bayanai suna ba da bayanin ƙarancin karuwa na INR a cikin marasa lafiya tare da haɗin acenocumarol ko warfarin da amoxicillin. Idan ya cancanta, yin amfani da lokaci guda tare da maganin hana daukar ciki, PV ko INR ya kamata a sa ido sosai a lokacin da aka tsara ko dakatar da miyagun ƙwayoyi.

Haɗewa tare da rifampicin antagonistic ne (raunana juna na antibacterial sakamako). Kada a yi amfani da Amoxiclav ult a lokaci guda a hade tare da kwayoyin rigakafin ƙwayoyin cuta (macrolides, tetracyclines), sulfonamides saboda raguwar yiwuwar tasirin Amoxiclav ®.

Amoxiclav ® yana rage tasirin maganin hana haifuwa.

Don allunan da za'a iya tarwatsa allunan da foda don dakatarwa don sarrafa maganin baka

Theara haɓakar tasiri na maganin rashin daidaituwa na jiki (hana ƙwayar microflora na hanji, rage haɓakar bitamin K da bayanan prothrombin). A wasu halaye, shan miyagun ƙwayoyi na iya tsawanta da PV, a wannan batun, ya kamata a kula yayin amfani da maganin rashin ƙarfi da magani na Amoxiclav ® Quicktab.

Probenecid yana rage haɓakar amoxicillin, yana ƙaruwa da ƙwaƙwalwar magani.

A cikin marasa lafiya da ke karɓar mofetil na mycophenolate, bayan fara amfani da haɗarin amoxicillin tare da clavulanic acid, an lura da raguwar haɗarin metabolite mai aiki, mycophenolic acid, kafin ɗaukar kashi na gaba na miyagun ƙwayoyi da kusan 50%. Canje-canje a cikin wannan taro ba zai iya nuna daidai canje-canje na bayyanar mycophenolic acid ba.

Don foda don shiri na mafita don gudanar da iv

Tsarin rigakafin Amoxiclav ® da aminoglycoside sun kasance sunadarai masu jituwa.

Kada a haɗar da Amoxiclav ® a cikin sirinji ko jiko na ciki tare da wasu kwayoyi.

Guji haɗuwa tare da mafita na dextrose, dextran, sodium bicarbonate, har ma tare da mafita mai dauke da jini, sunadarai, lipids.

Sashi da gudanarwa

Allunan mai rufe fim

A ciki. An tsara tsarin sashi daban-daban, gwargwadon shekarun, nauyin jikin, aikin koda, da kuma tsananin kamuwa da cuta.

Ana bayar da shawarar Amoxiclav ® a farkon cin abinci don mafi yawan abin sha da kuma rage tasirin sakamako daga tsarin narkewar abinci.

Aikin magani shine kwanaki 5-14. Dogon likitan ne ya tantance tsawon lokacin da ake bi da shi. Jiyya kada ta wuce kwanaki 14 ba tare da binciken likita na biyu ba.

Ana wajabta maganin gwargwadon shekaru da nauyin jiki. Tsarin shawarar da aka bada shawarar shine 40 MG / kg / rana a allurai uku.

Ya kamata a ba yaran da nauyin nauyin 40 kilogiram na sama da ƙari iri ɗaya kamar manya. Ga yara masu shekaru ≤6 shekara, ya fi dacewa a ɗauki dakatarwar na Amoxiclav ®.

Manya da yara sama da shekara 12 (ko> kilogiram 40 na nauyin jikin)

Yawanda aka saba idan akwai masu saurin kamuwa da cuta shine 1 kwamfutar hannu. 250 + 125 mg kowane 8 hours ko 1 kwamfutar hannu. 500 + 125 MG kowane sa'o'i 12, idan akwai mummunan kamuwa da cuta da cututtukan ƙwayar cuta - 1 tebur. 500 + 125 MG kowane 8 hours ko 1 kwamfutar hannu. 875 + 125 MG kowane 12 hours

Tunda allunan hadewar amoxicillin da clavulanic acid 250 + 125 mg da 500 + 125 mg kowannensu yana da adadin adadin acid na clavulanic - 125 mg, sannan allunan 2. 250 + 125 MG ba su dace da kwamfutar hannu 1 ba. 500 + 125 MG.

Sashi don kamuwa da cututtuka na odontogenic

Shafin 1. 250 + 125 mg kowane 8 hours ko 1 kwamfutar hannu. 500 + 125 MG kowane 12 na tsawon kwanaki 5.

Marasa lafiya tare da nakasa aiki na renal

Gyaran gyaran jiki ya dogara da matsakaiciyar shawarar da aka bayar ta maganin amoxicillin kuma ana aiwatar da ita cikin la'akari da ƙimar Cl creatinine:

- manya da yara sama da shekara 12 (ko ≥40 kilogiram na nauyin jiki) (tebur. 2),

- tare da cutar anuria, yakamata a kara tsakanin tazarar zuwa 48 ko kuma sama da haka,

- 875 + 125 allunan magunguna ya kamata a yi amfani dasu kawai a cikin marasa lafiya tare da Cl creatinine> 30 ml / min.

Foda don maganin dakatarwa

Yawan maganin yau da kullun na dakatarwa shine 125 + 31.25 mg / 5 ml da 250 + 62.5 mg / 5 ml (don sauƙaƙe allurar da ta dace, a cikin kowane kunshin na dakatar da 125 + 31.25 mg / 5 ml da 250 + 62.5 mg / 5 ml, pip 5 ml wanda aka sauke tare da sikelin 0.1 ml ko cokali 5 ml, ana sakawa. Alamun shekara a cikin ramin 2.5 da 5 ml).

Jariri da yara har zuwa watanni 3 - 30 MG / kg / rana (bisa ga amoxicillin), an kasu kashi biyu (kowane awanni 12).

Yin allurar miyagun ƙwayoyi Amoxiclav ® tare da dosing pipette - lissafin adadin allurai don maganin cututtukan cikin jarirai da yara har zuwa watanni 3 (Table 3).

Yara sama da wata 3 - daga 20 mg / kg don kamuwa da cuta mai sauƙi zuwa matsakaici mai ƙarfi zuwa 40 MG / kg don kamuwa da cuta mai rauni da ƙananan ƙwayar jijiyoyin jiki, otitis media, sinusitis (amoxicillin) kowace rana, sun kasu kashi uku (kowane 8 hours).

Yin allurar miyagun ƙwayoyi Amoxiclav ® tare da dosing pipette - lissafin allurai guda ɗaya don kula da cututtukan ƙwaƙwalwa masu laushi da matsakaici a cikin yara sama da watanni 3 (dangane da 20 mg / kg / day (don amoxicillin) (Table 4).

Yin allurar miyagun ƙwayoyi Amoxiclav ® tare da dosing pipette - lissafin allurai guda ɗaya don kula da cututtukan cututtukan ƙwaƙwalwa a cikin yara masu shekaru 3 (bisa 40 mg / kg / rana (don amoxicillin) (Table 5).

Yin allurar miyagun ƙwayoyi Amoxiclav ® tare da cokali mai magani (in babu pipin sashi) - shawarar da aka bayar na dakatarwar ya dogara da nauyin jikin yaro da tsananin kamuwa da cuta (Table 6).

Kusan kowace rana na dakatarwar 400 mg + 57 mg / 5 ml

Ana lasafta kashi da kilogram na nauyin jikin mutum, gwargwadon tsananin kamuwa da cuta. Daga 25 mg / kg don kamuwa da cuta mai sauƙi zuwa matsakaici mai ƙarfi zuwa 45 MG / kg don kamuwa da cuta mai rauni da ƙananan cututtukan numfashi, otitis media, sinusitis (cikin sharuddan amoxicillin) kowace rana, sun kasu kashi biyu.

Don sauƙaƙe allurar da ta dace, an sanya fitowar 400 mg + 57 mg / 5 ml a cikin kowane kunshin dakatarwa, an saka bututun dosing, an yi karatun digiri a lokaci ɗaya a cikin 1, 2, 3, 4, 5 ml da 4 daidai daidaito.

Ana amfani da dakatarwar 400 mg + 57 mg / 5 ml a cikin yaran da suka girmi watanni 3.

Matsakaicin shawarar dakatarwa ya dogara da nauyin jikin ɗan yaro da tsananin girman kamuwa da cuta

Ana yin lissafin ainihin allurai na yau da kullun gwargwadon nauyin jikin ɗan, ba wai shekarun sa ba.

Matsakaicin ƙwayar cuta na yau da kullum shine 6 g ga manya da 45 mg / kg ga yara.

Matsakaicin adadin yau da kullun na clavulanic acid (a cikin nau'i na gishiri na potassium) shine 600 mg ga manya da 10 mg / kg ga yara.

A cikin marasa lafiya da ke fama da rauni na aikin ƙirar, ya kamata a daidaita sashi ta hanyar gwargwadon shawarar da aka bayar da maganin amoxicillin.

Marasa lafiya tare da creatinine Cl> 30 ml / min ba sa buƙatar daidaitawar kashi.

Manya da yara masu nauyin sama da kilogiram 40 (ana amfani da tsarin allurai da aka yi amfani dasu don kamuwa da cuta na matsakaici da ƙarfi)

Marasa lafiya tare da Cl creatinine 10-30 ml / min - 500/125 mg sau 2 a rana.

Lokacin da Cl creatinine Cl creatinine 10-30 ml / min, maganin da aka bada shawarar shine 15 / 3.75 mg / kg sau 2 a rana (matsakaicin mg 500/125 sau 2 a rana).

Tare da Cl creatinine iv

Yara: tare da nauyin jikin ƙasa da 40 kilogiram - ana lissafta kashi gwargwadon nauyin jikin mutum.

Kasa da watanni 3 tare da nauyin jiki kasa da 4 kilogiram - 30 MG / kg (cikin sharuddan duka miyagun ƙwayoyi Amoxiclav ®) kowane 12 hours

A karkashin watanni 3 tare da nauyin jiki fiye da 4 kilogiram - 30 MG / kg (cikin sharuddan duka miyagun ƙwayoyi Amoxiclav ®) kowane 8 hours

A cikin yara ƙasa da watanni 3, Amoxiclav ® ya kamata a gudanar da shi a cikin jiko a hankali kawai na tsawon minti 30-40.

Yara daga watanni 3 zuwa shekaru 12 - 30 MG / kg (cikin sharuddan duka shiri na Amoxiclav ®) tare da tazara na awanni 8, idan akwai wani mummunan kamuwa da cuta - tare da tazara na awanni 6

Yaran da ke fama da rauni aiki

Gyaran gyaran jiki ya dogara da matsakaicin shawarar da aka bayar da maganin amoxicillin. Ga marasa lafiya tare da Cl creatinine sama da 30 ml / min, gyara kashi ba lallai ba ne.

Yaran da ke yin la'akari da Cl creatinine 10-30 ml / min25 MG / 5 MG a 1 kg a kowace awa 12 Cl creatinine ® ya ƙunshi 25 mg na amoxicillin da 5 MG na clavulanic acid.

Manya da yara sama da shekara 12 ko yin nauyi sama da kilo 40 - 1.2 g na miyagun ƙwayoyi (1000 + 200 MG) tare da tazara na awanni 8, idan akwai wani mummunan kamuwa da cuta - tare da tazara na awanni 6

Allurai na rigakafin hanyoyin tiyata: 1,2 g tare da haifar da cutar sankara (tare da tsawon lokacin tiyata kasa da sa'o'i 2). Don tsawon aiki - 1.2 g zuwa sau 4 a rana.

Ga marasa lafiya da ƙarancin na koda, kashi da / ko tazara tsakanin injections na miyagun ƙwayoyi ya kamata a daidaita su gwargwadon ƙarancin ƙarancin:

Tunda 85% na miyagun ƙwayoyi an cire shi ta hanyar hemodialysis, a ƙarshen kowane hanyar hemodialysis, dole ne ku shigar da kashi na al'ada na Amoxiclav ®. Tare da dialysis na peritoneal, ba a buƙatar daidaita sashi na kashi.

Aikin magani shine kwanaki 5-14. Dogon likitan ne ya tantance tsawon lokacin da ake bi da shi. Tare da raguwa a cikin tsananin bayyanar cututtuka, sauyawa zuwa nau'ikan maganganu na bakin na Amoxiclav ® ana bada shawara don ci gaba da ilimin.

Shiri don mafita don allurar iv. Rage abubuwan da ke cikin murfin a cikin ruwa don allura: 600 MG (500 + 100 mg) a cikin ruwa na 10 ml don allura ko 1.2 g (1000 + 200 mg) a cikin 20 ml na ruwa don allura. In / in shiga a hankali (a tsakanin mintuna 3-4).

Dole ne a gudanar da Amoxiclav ® a cikin minti 20 bayan shirye-shiryen mafita don gudanar da iv.

Shiri na mafita don iv jiko. Don kula da jiko na Amoxiclav ®, ƙarin dilution wajibi ne: shirya mafita wanda ya ƙunshi 600 MG (500 + 100 MG) ko 1.2 g (1000 + 200 MG) na miyagun ƙwayoyi ya kamata a diluted a cikin 50 ko 100 ml na jiko bayani, bi da bi. Tsawon lokacin jiko shine minti 30-40.

Lokacin amfani da taya mai zuwa a cikin shawarar da aka ba da shawara a cikin hanyoyin jiko, ana kiyaye abubuwan da ake buƙata na rigakafi:

Ba za a iya haɗa maganin maganin miyagun ƙwayoyi na Amoxiclav with tare da maganin dextrose, dextran ko bodiarbon sodium.

Kadai bayyananne mafita yakamata ayi amfani dashi. Kada a yi mafita mai daskarewa.

A ciki. An saita tsarin sashi daban-daban gwargwadon shekarun, nauyin jikin mutum, aikin ƙodan mai haƙuri da tsananin kamuwa da cuta.

Dole ne a narkar da Allunan a cikin rabin gilashin ruwa (aƙalla 30 ml) kuma a cakuda shi sosai, sannan a sha ko a riƙe allunan a bakin har sai an narkar da su gaba ɗaya, sannan a hadiye.

Don rage haɗarin sakamako masu illa daga cututtukan hanji, ya kamata a sha miyagun ƙwayoyi a farkon abincin.

Allunan 500 MG / 125 mg:

Manya da yara sama da shekara 12 tare da nauyin jiki ≥40 kg

Don lura da cututtukan cututtukan ƙwayar cuta zuwa ƙarancin matsakaici - 1 tebur. (500 MG / 125 MG) kowane awa 12 (sau 2 a rana).

Don lura da mummunan cututtuka da cututtuka na tsarin numfashi - 1 tebur. (500 MG / 125 MG) kowane 8 hours (sau 3 a rana).

Matsakaicin adadin yau da kullun na Amoxiclav ® Quicktab shine 1,500 mg na amoxicillin / 375 mg na clavulanic acid.

Marasa lafiya tare da nakasa aiki na renal. A cikin marasa lafiya tare da creatinine Cl sama da 30 ml / min, daidaita sashi ba lallai ba ne.

Manya da yara kanana shekaru 12 da suka kamu da nauyin ≥40 kilogiram (ana amfani da allurar rigakafin da aka nuna don kamuwa da cuta).

Manya da yara sama da shekara 12 tare da nauyin jiki ≥40 kg

A cikin mummunan cututtuka da cututtukan numfashi - 1 tebur. (875 mg / 125 mg) a kowace sa'a 12 (sau 2 a rana).

Adadin magani na yau da kullun na Amoxiclav ® Quicktab lokacin amfani da shi sau 2 a rana shine 1750 mg na amoxicillin / 250 mg na clavulanic acid.

Marasa lafiya tare da nakasa aiki na renal. A cikin marasa lafiya tare da Cl creatinine mafi girma fiye da 30 ml / min, babu buƙatar daidaita sashi.

Ga marasa lafiya tare da Cl creatinine ƙasa da 30 ml / min, amfani da kwalayen warwatattun magungunan ƙwayar cuta mai suna Amoxiclav ® Quicktab, 875 mg / 125 mg sune contraindicated.

Irin waɗannan marasa lafiya ya kamata su sha maganin a gwargwadon ƙarfin 500 mg / 125 mg bayan daidaitawar kashi da ya dace na creatinine Cl.

Marasa lafiya tare da nakasa aikin hanta. Lokacin ɗaukar Amoxiclav ® Quicktab, ya kamata a yi taka tsantsan. Kulawa ta yau da kullun game da aikin hanta ya zama dole. A cikin taron cewa an fara jiyya tare da tsarin kulawa da maganin, yana yiwuwa a ci gaba da maganin tare da allunan Amoxiclav ® Quicktab.

Tsawan likitan ne zai tantance tsawon lokacin da ake bi da shi ba!

Mafi karancin hanyoyin maganin rigakafi shine kwanaki 5. Bai kamata magani ya ci gaba sama da kwanaki 14 ba tare da sake nazarin yanayin asibiti ba.

Yawan abin sama da ya kamata

Babu wani rahoton mutuwa ko cutar da ke haifar da barazanar rayuwa saboda yawan shan kwayoyi.

Kwayar cutar A mafi yawancin lokuta, rikicewar jijiyoyin ciki (ciwon ciki, zawo, amai), tashin hankali, rashin bacci, tsananin kishi ma hakan zai yiwu, a lokuta da dama na fama da tashin zuciya.

Jiyya: Idan akwai wani yawan abin sama da ya kamata, mai haƙuri ya kamata ya kasance karkashin kulawar likita, magani alama ce.

Game da gwamnatin kwanan nan (kasa da awanni 4) na miyagun ƙwayoyi, ya wajaba a wanke ciki kuma a rubuta maganin gawayi don rage sha. Ana cire maganin amoxicillin / potassium clavulanate ta hanyar hemodialysis.

Umarni na musamman

Ga dukkan siffofin sashi

Tare da hanya, ana buƙatar saka idanu kan yanayin aikin jini, hanta, da kodan.

A cikin marasa lafiya da rauni mai girma na renal, ana buƙatar daidaita daidaitaccen kashi ko karuwa a tsakani tsakanin allurai.

Zai yuwu a haɓaka superinfection saboda haɓakar microflora wanda ba shi da hankali, wanda ke buƙatar canji mai dacewa a cikin maganin rigakafi.

A cikin marasa lafiya tare da tashin hankali zuwa maganin penicillins, halayen-rashin lafiyan halayen rigakafi tare da maganin rigakafin cephalosporin mai yiwuwa.

A cikin mata masu rauni wanda ke cikin membranes, an gano cewa prophylactic therapy tare da amoxicillin + clavulanic acid na iya haɗuwa da haɓakar haɗarin kamuwa da cuta a cikin jarirai.

A cikin marasa lafiya da rage diuresis, crystalluria yana da wuya sosai. Yayin amfani da manyan allurai na amoxicillin, ana bada shawara don ɗaukar isasshen ƙwayar ruwa da kuma kula da isasshen diuresis don rage yiwuwar samuwar lu'ulularillin.

Gwaje-gwaje na dakin gwaje-gwaje. Babban yawan amoxicillin yana ba da amsa ta gaskiya ga ƙin fitsari yayin amfani da renoent na Benedict ko Feling. Ana bada shawarar halayen enzymatic tare da glucosidase.

Don allunan da za'a iya tarwatsa allunan da foda don dakatarwa don sarrafa maganin baka

Kafin fara magani, ya zama dole a yi wa mai haƙuri tambayoyi don gano tarihin rashin lafiyar ƙwayar cuta ga maganin penicillins, cephalosporins, ko wasu maganin rigakafin beta-lactam.

Don rage haɗarin sakamako masu illa daga cututtukan gastrointestinal, ya kamata a sha miyagun ƙwayoyi kafin ko lokacin abinci.

Lokacin amfani da babban allurai na Amoxiclav ® Quiktab, marassa lafiya tare da kwalayen ƙwayar cuta suna buƙatar wadataccen maye gurbin ƙwayar cuta sosai.

Idan ƙwayar cuta mai alaƙa da ƙwayar cuta ta faru, dakatar da Amoxiclav ® Quicktab, nan take, shawarci likita kuma fara magani da ya dace. Magungunan kwayoyi masu hana maye haɓakar peristalsis sun haɗu a cikin irin wannan yanayi.

Dole ne lura ya ci gaba har zuwa awanni 48 zuwa 52 bayan bacewar alamun asibiti. Ta amfani da hanyoyin hana daukar ciki na kwayar cutar kwayar cutar kwayar cutar kwayar cutar kwayoyi da amoxicillin, sauran ko ƙarin hanyoyin hana haihuwa idan ya yiwu.

Amoxicillin da clavulanic acid na iya tsokanar da rashin daidaituwa na immunoglobulins da albumin ga membrane na erythrocyte, wanda zai iya zama sanadin maganganu na karya game da gwajin Coombs.

Amfani da amoxicillin da clavulanic acid an hana shi cikin cututtukan mononucleosis, saboda na iya tsokanar kamuwa da cutar kyanda.

Gargaɗi na musamman don zubar da magani mara amfani. Babu buƙatar rigakafin musamman yayin zubar da Amoxiclav un mara amfani.

Tasiri kan iya tuƙin mota ko yin aikin da ke buƙatar haɓakar haɓakar halayen jiki da na tunani. Sakamakon yiwuwar haɓaka sakamako masu illa daga tsarin juyayi na tsakiya, kamar suma, ciwon kai, da raɗaɗi, ya kamata a yi taka tsantsan yayin jiyya lokacin tuki da sauran ayyukan buƙatar buƙatar hankali da saurin halayen psychomotor.

Don allunan da aka sanya fim, allunan da za'a iya rabawa, foda don dakatarwar baka, bugu da kari

Don rage haɗarin sakamako masu illa daga cututtukan gastrointestinal, ya kamata a sha miyagun ƙwayoyi tare da abinci.

Don foda don shiri na mafita don gudanar da iv

Amoxicillin da clavulanic acid na iya tsokanar da rashin tsari na immunoglobulins da albumin ga membrane na erythrocyte, wanda zai iya zama sanadin ingancin gwajin Coombs na gaskiya.

Bayani ga marasa lafiya game da karancin abincin sodium: kowane 600 mg vial (500 + 100 mg) ya ƙunshi 29.7 mg na sodium. Kowane vial na 1.2 g (1000 + 200 mg) ya ƙunshi 59.3 mg na sodium. Adadin sodium a cikin adadin mafi yawan yau da kullun ya wuce 200 MG.

Fom ɗin saki

Allunan da aka sanya fim, 250 MG + 125 MG. Allunan 15, 20 ko 21. da abubuwa masu kyau 2 (silica gel) a cikin akwati jan zagaye tare da kalmar “inedible” a cikin kwalbar gilashin duhu da aka yi ɗamara tare da ƙwanƙarar murfin ƙarfe tare da zoben sarrafawa tare da lalata da kuma dutsen LDPE a ciki. 1 fl. a cikin wata kwali.

Allunan da aka sanya fim, 500 MG + 125 MG. Allunan 15 ko 21. da abubuwa masu kyau 2 (silica gel) a cikin akwati jan zagaye tare da kalmar “inedible” a cikin kwalbar gilashin duhu da aka yi ɗamara tare da ƙwanƙarar murfin ƙarfe tare da zoben sarrafawa tare da lalata da kuma dutsen LDPE a ciki. 1 fl. a cikin wata kwali.

Allunan 5 ko 7. a cikin farin ciki na furen allo mai farin gashi / alumini mai taushi. Alƙura biyu, 3 ko 4 don allunan 5. ko maganin blister 2 na allunan guda 7. a cikin wata kwali.

Allunan da aka sanya fim, 875 MG + 125 MG. Allunan 5 ko 7. a cikin farin ciki na furen allo mai farin gashi / alumini mai taushi. 2 ko 4 blister don Allunan 5. ko maganin blister 2 na allunan guda 7. a cikin wata kwali.

Foda don dakatarwar baka, 125 mg + 31.25 mg / 5 ml ko 250 mg + 62.5 mg / 5 ml. Fakitin farko - 25 g na foda (100 ml na dakatarwa) a cikin gilashin gilashi mai duhu tare da alamar zobe (100 ml). An rufe kwalbar da dunƙule-kan ƙarfe mai ƙyalli tare da zoben sarrafawa, a cikin hula akwai gasket ɗin da aka yi da LDPE.

Sakandare na biyu - 1 fl. tare da sashi na yanka tare da alamun shekara a cikin ramin 2.5 da 5 ml ("2.5 SS" da "5 SS"), alamar madaidaicin cika 6 ml ("6 SS") a kan riƙe da cokali a cikin kwali. Ko 1 fl. tare da pipette masu digiri a cikin kwali.

Foda don dakatarwar baka, 400 MG + 57 MG / 5 ml. Fakitin farko - 8.75 g (35 ml na dakatarwa), 12.50 g (50 ml na dakatarwa), 17.50 g (70 ml na dakatarwa) ko 35.0 g (140 ml na dakatarwa) na foda a cikin vial gilashin duhu mai duhu tare da murfin dunƙule wanda aka yi da HDPE tare da zobe mai sarrafawa tare da gurneti a cikin murfin.Ko 17.5 g (70 ml na dakatarwa) a cikin gilashin gilashi mai duhu tare da alamar zobe (70 ml) tare da dunƙule dunƙule wanda aka yi da HDPE tare da zobe mai sarrafawa tare da gurneti a cikin murfin.

Sakandare na biyu - 1 fl. tare da pipette masu digiri a cikin kwali.

Foda don bayani don gudanarwar cikin zuciya, 500 MG + 100 MG ko 1000 MG + 200 MG. 500 MG na amoxicillin da 100 MG na clavulanic acid ko 1000 mg na amoxicillin da 200 MG na clavulanic acid a cikin kwalban gilashin mara launi, an rufe shi tare da matattakalar roba da ƙarar allon aluminum tare da filastik filastik. 5 fl. sanya shi a cikin kwali.

Allunan da ba a yarda dasu ba, 500 mg + 125 mg ko 875 mg + 125 mg. Allunan 2 cikin fara'a. 5 ko 7 blisters an sanya su a cikin kwali na kwali.

Mai masana'anta

Lek dd Verovshkova 57, Ljubljana, Slovenia.

Don foda don shiri na mafita don gudanarwa na ciki bugu da .ari

1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.

2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.

Ya kamata a aika da sanarwa game da masu amfani da kayayyaki zuwa Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, shafi 1.

Waya: (495) 660-75-09, fakis: (495) 660-75-10.

Amoxiclav ®

allunan da aka sanya fim 250 MG + 125 MG 250 MG + 125 - 2 years.

allunan da aka sanya fim - 500 MG + 125 MG 500 MG + 125 - 2 shekaru.

Allunan-fim mai nauyin 875 mg + 125 mg 875 mg + 125 - 2 shekaru.

foda don shirye-shiryen samar da mafita don gudanarwar cikin ciki na 500 MG + 100 MG 500 MG + 100 - 2 shekaru.

foda don shirye-shiryen samar da mafita don gudanarwar cikin ciki na 1000 mg + 200 mg 1000 mg + 200 - 2 shekaru.

Kwayoyin da aka watsar dasu 500 MG + 125 MG 500 MG + 125 - 3 years.

Kwayoyin da aka watsar dasu na 875 mg + 125 mg 875 mg + 125 - 3 years.

foda don dakatarwa don sarrafa bakin 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 shekaru. Dakatarwar da aka gama ita ce kwana 7.

foda don dakatarwa don gudanar da maganin baka 250 mg + 62.5 mg / 5 ml 250 mg + 62.5 mg / 5 - 2 shekaru. Dakatarwar da aka gama ita ce kwana 7.

foda don dakatarwa don gudanarwa na baka 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 shekaru. Dakatarwar da aka gama ita ce kwana 7.

Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Abun da ke ciki da kayan aikin magunguna na Amoxiclav 125 milligrams

MG na 125 ya ƙunshi:

1. Amoxicillin - yana nufin maganin penicillins waɗanda suke iya amsawa da halakar da ɗimbin ƙwayoyin cuta daga ƙasashen waje da ƙwayoyin cuta.
2. Clavulanic acid shine beta-lactam, wanda ke rage jinkirin lalata babban bangaren sabili da haka yana tsawanta kwayoyin kwayoyin penicillin a cikin jiki.

Tsarin saki da abun da ke ciki na miyagun ƙwayoyi yana ba da damar marasa lafiya a cikin mafi yawan yanayi don yaƙar cutar ba tare da yin tunani game da mummunar cutar da jiki ba. Yawancin ƙwararrun kwararru suna magana da magani a matsayin ɗayan mafi sauƙi ga yara da manya suyi karatu.

Umarnin don amfani da nau'in fitarwa ya bayyana allunan Amoxiclav da dakatarwar Amoxiclav (ƙarin takamaiman, foda don shirye-shiryen dakatarwa).

Ban sha'awa! Akwai amoxiclav quiktab, wanda yake nan take, duk da haka, ana siyar dashi ne kawai a cikin adadin 625 mg da 1000 mg.

Tare da tattarawa na musamman na abubuwa masu aiki, wato 5 ml na miyagun ƙwayoyi = MG 125 na amoxicillin + 31.5 MG na clavulanic acid, yana taimakawa wajen magance cututtuka.

Bayanin maganin yana tabbatar da cewa miyagun ƙwayoyi sun kashe gungun kwayoyin cuta da ƙwayoyin cuta. Sau da yawa suna cewa Amoxiclav 125 na yara ne, tunda yana cikin nau'in ruwa, wanda ke sauƙaƙe amfani.

Yadda ake yin kiwo

Don koyon yadda ake ɗaukar shi ga yara, kuma mafi mahimmanci ga yadda ake tsinke amoxiclav daidai, ya kamata a koma zuwa umarnin don amfani:

1. Shake kwalban foda don kwance da foda.
2. Toara a cikin kwalban ruwan tsarkakakken farko zuwa tsakiyar kwalbar ya girgiza, sannan ka ƙara ruwa a cikin kwalbar, amma tuni ya yi kama da alamar a jikin kwalbar. Bayan wannan, sake girgiza dakatarwar Amoxiclav.

Tsarma da miyagun ƙwayoyi tare da milliliters 86 na ruwa, kuma dakatarwar da aka ƙare don yara a cikin budewa mako ne.

Ban sha'awa! Hanyar shirya dakatarwar Amoxiclav 125 MG zuwa yaro mai shekaru biyu ba zai bambanta ta kowace hanya daga dilution na miyagun ƙwayoyi ga yaro ɗan shekara 12. Yana da mahimmanci yin ƙididdigar gwargwado daidai don syrup ya sami tasiri.

Nawa ne za a ɗauka

Amoxiclav bisa ga umarnin ya kamata a ɗauka daga 5 zuwa 7 kwanaki, duk da haka, kamar yadda likita ya umarta, zaku iya sha maganin har zuwa makonni biyu. Fiye da kwanaki 14, ɗaukar Amoxiclav 125 ba zai dace ba, saboda yuwuwar yin amfani da miyagun ƙwayoyi.

Babban abin da za a tuna lokacin shan Amoxiclav 125 MG shine cewa kwanaki nawa za a yi amfani da miyagun ƙwayoyi ya kamata ƙaddara ta likita ta halarta. Vioarya umarnin umarnin likitan yara zai iya haifar da sakamako masu illa.