Glucophage Tsayi > Magunguna

Bayanin da ya dace da 15.12.2014

Sunan Latin: Glucophage mai tsawo
Lambar ATX: A10BA02
Aiki mai aiki: Metformin (Metformin)
Mai masana'anta: 1. MERC SANTE SAAS, Faransa. 2. Merck KGaA, Jamus.

Allunan aiki na tsawon lokaci suna dauke da 500 ko 750 mg na abu mai aiki - metformin hydrochloride.

Componentsarin abubuwan da aka haɗa: sodium carmellose, hypromellose 2910 da 2208, MCC, magnesium stearate.

Magunguna da magunguna

Metformin ne biguanidetare da hypoglycemicsakamakosami damar runtse taroglucose a cikin jini na jini. Koyaya, hakan ba ya tayar da aikin insulinsaboda haka ba ya haifar yawan haila. A yayin jiyya, masu karɓa na waje sun zama masu hankali ga insulin, kuma yawan amfani da glucose ta ƙwayoyin suna ƙaruwa. Rage glucose na hanta an rage shi saboda hanawar glycogenolysis da gluconeogenesis. Jinkirta sha daga cikin suga a cikin narkewa.

Aiki sashi na maganin yana karfafa samar da glycogen ta hanyar aiki akan glycogen synthase. Capacityara ƙarfin jigilar kowane jigilar mahaifa membrane.

A cikin jiyya metformin marasa lafiya suna riƙe nauyin jiki ko lura da raguwa na matsakaici. Abun yana da tasiri mai amfani akan metabolism na lipid: rage matakin jimlar cholesterol triglycerides da LDL.

Allunan da aka yi aiki suna dauke da yanayin jinkiri. Saboda haka, tasirin warkewa yaci gaba da aƙalla tsawon sa'o'i 7. Rashin ƙwayar ba ya dogara da abinci kuma baya haifar da tarin yawa. An lura da ƙima sosai ga furotin plasma. Metabolism yana faruwa ba tare da samuwar metabolites ba. Caukar abubuwan da aka gyara suna faruwa a cikin tsari wanda ba a canzawa tare da taimakon kodan.

Alamu don amfani

An ƙayyade Glucophage Long don nau'in ciwon sukari na 2 a cikin tsofaffi marasa lafiya tare da kiba a cikin lokuta na rashin abinci mai gina jiki da kuma aiki na jiki kamar:

monotherapy
haɗe tare da magani tare da sauran magungunan hypoglycemic ko insulin.

Contraindications

Ba a sanya magani ba ga:

hankalidon samar da metformin da sauran kayan aikin,
mai fama da ciwon sukari ketoacidosis, prema
karancin koda ko isasshen koda ko aikin hanta,
m siffofin da dama cututtuka,
m rauni da aiki,
na kullum barasabarasa maye
ciki
lactic acidosis,
yi amfani da awanni 48 kafin ko bayan radioisotope ko nazarin-rayuwa-da suka shafi gabatarwar wani aidin mai dauke da sabanin matsakaici,
abuncin hypocaloric,
kasa da shekara 18.

Ya kamata a yi taka tsantsan yayin rubuta wannan magani dangane da marasa lafiyar tsofaffi, mutanen da suke yin aiki na zahiri, domin hakan na iya haifar da ci gaba lactic acidosisa cikin kula da mata masu shayarwa.

Side effects

Yayin maganin ƙwayar cuta, haɓaka mai yiwuwa ne lactic acidosis, megaloblastic anemia, rage sha na bitamin B12.

Hakanan, ba a cire damuwa a cikin aiki na tsarin juyayi ba - canji na dandano, aikin motsa jiki - tashin zuciya, amai, zafi, zawo, asarar ci. Yawanci, waɗannan alamun suna da damuwa a farkon jiyya kuma a hankali sun ɓace. Don hana ci gaban su, an shawarci marasa lafiya su dauki metformin tare ko kuma nan da nan bayan cin abinci.

A cikin halayen da ba a sani ba, rashin ƙarfi a cikin aikin hanta da bile, wata alama ce ta fata halayen rashin lafiyan halayen.

Yawan abin sama da ya kamata

Yanayin aiki metformin a sashi na kasa da 85 g ba ya haifar da ci gaban hypoglycemia. Amma har yanzu akwai damar ci gaba lactic acidosis.
Lokacin da bayyanar cututtukan lactic acidosis, ya zama dole a dakatar da shan magungunan, nan da nan a asibiti, a tantance taro na lactate, tare da yin bayani game da cutar. An lura da ingancin hanyar don cire lactate da metformin daga jiki ta amfani da maganin hemodialysis. Hakanan ana yin aikin kwantar da hankali tare da cututtukan alamu.

Haɗa kai

Ci gaba lactic acidosis Zai iya haifar da haɗuwa da miyagun ƙwayoyi tare da jami'ai masu ɗauke da sinadarin aidin. Saboda haka, tsawon awanni 48 kafin da bayan gwajin rediyo ta amfani da kayan maye na iodine, ana bada shawarar soke Glucophage Long.

Yin amfani da magunguna a lokaci guda tare da tasirin rikicewar kaikaice - magungunan hormonal ko tetracosactidekazalika β2-adrenergic agonists, danazol, chlorpromazine da kamuwa da cutana iya shafar taro na glucose a cikin jini. Sabili da haka, wajibi ne don sarrafa alamunsa, kuma idan ya cancanta, aiwatar da daidaitawar sashi.

Bugu da kari, a gaban na na gazawarkamuwa da cutainganta ci gaba lactic acidosis. Haɗuwa da sulfonylureas, acarbose, insulin, salicylates sau da yawa yakan haifar da ƙwanƙwasa jini.

Haɗuwa da amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprimda dayananan, wanda aka ɓoye a cikin tubules na koda, sun shiga cikin gasa tare da metformin don jigilar tubular, wanda ke ƙaruwa da hankali.

Ranar karewa

Babban analogues na wannan magani: Bagomet, Glycon, Glyformin, Glyminfor, Langerine, Metospanin, Metadiene, Metformin, Siafor da sauransu.

Amfani da barasa yana kara yiwuwar haɓaka lactic acidosis a cikin m barasa maye. An lura da strengtheningarfin ƙarfafa yayin azumi, bin wani ƙarancin kalori, da kasancewar rashin hanta. Saboda haka, amfani da giya yayin jiyya ya kamata a jefar da shi.

Nazarin Glucophage

Sau da yawa yawancin lokaci, marasa lafiya suna barin sake dubawa game da Glucofage Long 750 MG, tunda an wajabta wannan sashi lokacin jiyya nau'in ciwon sukari na 2 a matakinsa na tsakiya. A wannan yanayin, yawancin marasa lafiya suna lura da isasshen tasiri na maganin. Sau da yawa akwai rahotanni cewa lokacin da masu ciwon sukari suka ɗauki nauyin jikinsu mai nauyi, to daga baya sun lura da raguwar matsakaicin nauyi zuwa ga alamu masu karɓuwa.

Amma ga Glucofage xr 500, to ana iya ba da magani a cikin wannan sashi a matakin farko na magani. Nan gaba, ana barin haɓakar hankali a hankali har sai zaɓi ya fi tasiri.

Ya kamata a sani cewa ƙwararren masani ne kaɗai zai iya ba da kowane irin magunguna na cututtukan zuciya. Baya ga aikin likita da ya cancanta, likita zai ba da shawarar canje-canje a cikin abinci mai gina jiki, motsa jiki, wanda ya kamata ya zama wani ɓangare mai mahimmanci ga rayuwar mutanen da ke fama da ciwon sukari. Wannan hanyar kawai za ta tabbatar da ingantacciyar rayuwa kuma ba za ta ji daɗin duk alamun da ba a ke so ba na wannan cin zarafin.

Formaddamar da tsari da abun da ke ciki

Allunan aiki na tsawon lokaci suna dauke da 500, 750 ko 1,000 MG na metformin hydrochloride mai aiki.

Abun ciki 1 kwamfutar hannu:

abu mai aiki: metformin hydrochloride - 500, 750 ko 1000 mg,
abubuwan taimako (500/750/1000 mg): sodium carmellose - 50 / 37.5 / 50 mg, microcrystalline cellulose - 102/0/0 mg, hypromellose 2208 - 358 / 294.24 / 392.3 mg, hypromellose 2910 - 10/0/0 mg, magnesium stearate - 3.5 / 5.3 / 7 mg.

Tasirin magunguna

Tasirin magunguna na metformin yana nufin rage sukarin jini, wanda zai iya ƙaruwa daga yawan abinci. Ga jikin mutum, wannan tsari na dabi'a ne, kuma aladu, wanda ke da alhakin samar da insulin, yana da hannu a ciki. Aikin wannan abu shine rushewar glucose zuwa ga mai mai.

A matsayin magani game da ciwon sukari da gyaran jiki, Glucophage Long yana yin ayyuka masu amfani da yawa:

Yana daidaita metabolism na lipid.
Yana sarrafa amsawar rushewar carbohydrates da canzawarsu zuwa kitse na jiki.
Yana daidaita matsayin glucose da cholesterol, wanda yake da haɗari ga jiki.
Yana tabbatar da samarda insulin na halitta, wanda yake rage yawan ci da kuma rasa madaidaiciya ga Sweets.

Lokacin da matakan glucose na jini suka ragu, ana aika da kwayoyin sukari kai tsaye zuwa tsokoki. Samun mafaka, sukari yana ƙonewa, kitse mai mai narkewa, tsarin sha na carbohydrates yana gudana cikin motsi mai sauri. Sakamakon haka, ci abinci ya zama matsakaici, ƙwayoyin kitse ba su tarawa ba a ajiye su a wasu sassan jikin mutum.

Umarnin don amfani

Umarnin don amfani yana nuna cewa Glucofage Long ana ɗauka ta baki sau 1 / rana, yayin abincin dare. Allunan an cinye shi duka, ba tare da taunawa ba, tare da isasshen ruwan sha.

Ya kamata a zaɓi kashi na maganin ɗin gaba ɗaya don kowane mai haƙuri dangane da sakamakon aunawa da haɗuwar glucose a cikin jini. Ya kamata a dauki Glucophage Long kowace rana, ba tare da tsangwama ba. Game da dakatar da magani, dole ne mai haƙuri ya sanar da likita game da wannan. Idan kun tsallake kashi na gaba, ya kamata a sha kashi na gaba a lokacin da aka saba. Karka ninka kashi biyu na Glucofage Long.

Monotherapy da haɗuwa da magani tare da sauran wakilai na hypoglycemic:

Ga marasa lafiya marasa shan metformin, shawarar da aka fara farawa na Glucofage Long shine 1 shafin. 1 lokaci / rana
Kowane kwanaki na 10-15 na magani, ana bada shawarar yin kwaskwarimar gwargwadon sakamakon ma'aunin taro na jini. Rage hawa a kashi na taimaka wajan rage tasirin sakamako daga hanji.
Yawan shawarar Glucofage Long shine 1500 MG (Allunan 2) 1 lokaci / rana. Idan, yayin ɗaukar shawarar da aka ba da shawarar, ba zai yiwu a sami isasshen ikon sarrafa glycemic ba, yana yiwuwa a ƙara kashi zuwa iyakar 2250 MG (allunan 3) 1 lokaci / rana.
Idan ba'a sami isasshen kulawar glycemic tare da allunan 3 ba. 750 MG 1 lokaci / rana, yana yiwuwa a canza zuwa shirye-shiryen metformin tare da sakin da aka saba na aiki mai aiki (misali, Glucofage, allunan da aka saka a fim) tare da matsakaicin adadin yau da kullun na 3000 MG.
Ga marasa lafiya da ke karbar magani tare da allunan metformin, kashi na farko na Glucofage Long ya zama daidai da kashi na yau da kullun na allunan tare da sakin da aka saba. Marasa lafiya suna shan metformin a cikin nau'ikan Allunan tare da sakin jiki na yau da kullun a cikin kashi wanda ya wuce 2000 MG ba'a bada shawarar canzawa zuwa Glucofage Long.
Idan akwai yiwuwar yin sauyawa daga wani wakili na hypoglycemic: yana da mahimmanci don dakatar da shan wani magani kuma fara shan Glucofage Long a kashi da aka nuna a sama.

Hadawa tare da insulin:

Don cimma ingantacciyar iko da tattarawar glucose na jini, ana iya amfani da metformin da insulin azaman maganin haɗuwa. Yawancin farko na Glucofage Long shine 1 shafin. 750 MG 1 lokaci / rana yayin abincin dare, yayin da aka zaɓi kashi na insulin dangane da ma'aunin glucose a cikin jini.

Umarni na musamman

Kafin fara magani kuma a kai a kai a nan gaba, ya kamata a ƙaddara tsabtacewar creatinine: in babu rikice-rikice, aƙalla lokaci 1 a cikin shekara, a cikin tsofaffi marasa lafiya, da kuma a cikin marasa lafiya da keɓancewar creatinine a ƙananan matakin al'ada, daga 2 zuwa sau 4 a shekara. Tare da keɓancewar creatinine ƙasa da 45 ml / min, amfani da Glucofage Long yana haɓaka.
An shawarci marasa lafiya su ci gaba da rage cin abinci tare da ɗimbin ƙwayoyin carbohydrates a cikin kullun.
Dukkanin cututtukan da suka kamu da cutar (hanjin kumburin hanji da kuma cututtukan hanji) da magani ya kamata a sanar da likitanka.
Wajibi ne yin la'akari da yiwuwar lactic acidosis tare da bayyanar cututtukan ƙwayar tsoka, wanda ke haɗuwa da ciwon ciki, dyspepsia, zazzabin ciwo da rauni gaba ɗaya.
Ya kamata a dakatar da miyagun ƙwayoyi awanni 48 kafin a fara aikin tiyata. Za a iya dawo da magani daga bayan sa'o'i 48, muddin a lokacin gwaji, an gano aikin na kowa ne kamar al'ada.
Lactic acidosis an san shi ta hanyar ciki, amai, gazawar hancin acidotic, ƙwanƙwasa fata da jijiyoyin wuya. Sigogi na gwajin ƙwayar cuta - raguwa a cikin pH na jini (5 mmol / l, haɓaka rabo na lactate / pyruvate da haɓaka ragin anionic. Idan ana zargin lactic acidosis, Glucofage Long yana kwance nan da nan.
A gaban yiwuwar aiki na ƙarancin aiki na ƙarancin aiki dangane da asalin haɗin gwiwa tare da magungunan antihypertensive, diuretics ko magungunan anti-mai kumburi ba a cikin tsofaffi marasa lafiya ba, ya kamata a kula da kulawa ta musamman.
Ana lura da haɗarin hauhawar hypoxia da gazawar koda a cikin marasa lafiya tare da raunin zuciya. Wannan rukunin marasa lafiya a yayin maganin yana buƙatar saka idanu akai-akai na aikin zuciya da yanayin aikin kodan.
Tare da kiba mai yawa, yakamata ku ci gaba da bin tsarin abinci mai ɗauke da jini (amma ba kasa da 1000 kcal a kowace rana ba). Hakanan, marasa lafiya suna buƙatar yin motsa jiki a kai a kai.
Don magance ciwon sukari, ya kamata a gudanar da gwaje-gwaje na yau da kullun a kai a kai.
Tare da monotherapy, Glucophage Long baya haifar da hypoglycemia, amma ana ba da shawarar yin hankali lokacin amfani dashi tare da insulin ko wasu wakilai na bakin jini na hypoglycemic. Babban alamun cututtukan hypoglycemia: karuwar gumi, rauni, rashi, ciwon kai, cututtukan fata, rashin hankali ko gani.
Sakamakon tarin metformin, mai saukin amma mai rikitarwa mai yiwuwa ne - lactic acidosis, wanda ke da yawan mace-mace yayin rashin magani na gaggawa. Mafi yawa yayin amfani da Glucofage Long, irin waɗannan lokuta sun faru a cikin ciwon sukari na mellitus a kan asalin lalacewar koda. Sauran abubuwan haɗari masu haɗari yakamata ayi la'akari dasu: ketosis, ciwon sikari mai rauni, tsawan azumi, gazawar hanta, yawan shan giya, da kowane yanayi da ke da alaƙar shaƙar rashin ƙarfi.
Abubuwanda basu da ƙarfi na Glucofage Long za'a iya fitar dasu ta hanji mara canzawa, wanda baya shafar aikin warkewa na miyagun ƙwayoyi.

Hulɗa da ƙwayoyi

Yin amfani da magunguna a lokaci guda tare da tasirin hyperglycemic kai tsaye - magungunan hormonal ko tetracosactide, kamar yadda tare da on2-adrenergic agonists, danazol, chlorpromazine da diuretics na iya shafar taro na glucose a cikin jini. Sabili da haka, wajibi ne don sarrafa aikinsa, kuma idan ya cancanta, aiwatar da daidaitawar sashi.

Bugu da kari, a cikin gaban gazawar koda, diuretics suna ba da gudummawa ga ci gaban lactic acidosis. Haɗuwa tare da abubuwan da aka samo na sulfonylurea, acarbose, insulin, salicylates sau da yawa suna haifar da hypoglycemia.

Haɓaka maganin lactic acidosis na iya haifar da haɗuwa da miyagun ƙwayoyi tare da wakilai masu dauke da maganin aidin. Saboda haka, tsawon awanni 48 kafin da bayan gwajin rediyo ta amfani da kayan maye na iodine, ana bada shawarar soke Glucophage Long.

Haɗuwa tare da amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim da vancomycin, waɗanda ke ɓoye a cikin tubules na koda, suna gasa tare da metformin don jigilar tubular, wanda ke ƙara mayar da hankali.

Mun dauki wasu sake dubawa game da rasa nauyi game da miyagun ƙwayoyi Glucofage:

Basil. Ina shan magani na sayan magani don rage sukari. An tsara kwamfutar hannu 1 a kowace kwala 750 sau ɗaya a rana. Kafin shan maganin, sukarin ya kasance 7.9. Makonni biyu baya, rage zuwa 6.6 a kan komai a ciki. Amma dubawata ba tabbatacce bane kawai.Da farko, ciki na yana ciwo, zawo ya fara. Mako guda baya, fara itching. Kodayake wannan ya nuna ta hanyar umarnin, likita zai tafi.
Marina Bayan bayarwa, sun ba da jarin insulin kuma sun ce wannan yawanci haka yake ga mutane masu kiba. An sanya shi don ɗaukar Glucofage Long 500. Ta ɗauki kuma ta ɗan daidaita tsarin abincin. Kika aika kimanin kilo 20. Babu shakka, akwai wasu sakamako masu illa, amma ita za ta zarge su. Don haka za mu ci ɗan kaɗan bayan mun ɗauki kwaya, sannan zan yi aiki da jiki - sannan kaina ya yi rauni. Sabili da haka - Allunan suna da ban mamaki.
Irina Na yanke shawarar shan Glucofage Long 500 don asarar nauyi. A gabansa, akwai ƙoƙari da yawa: duka tsarin wutar lantarki daban-daban, da motsa jiki. Sakamakon ba shi da gamsarwa, nauyin da ya wuce ya dawo da zaran abincin ya ci gaba. Sakamakon magani ya ba ni mamaki: Na rasa kilogram 3 a wata. Zan ci gaba da shan ruwa, kuma farashinsa ya yi yawa.
Svetlana Mahaifiyata tana da ciwon sukari na 2. Magungunan suna da tasiri. Matakan sukari sun ragu sosai. Har yanzu mahaifiyar ta kamu da kiba. Tare da wannan magani, Na yi nasarar rage nauyi, wanda yake da wahala cikin tsufa. Tana jin sauki sosai yanzu. Menene yafi dacewa - Glucophage Dogon lokaci yana buƙatar ɗaukar sau ɗaya kawai a rana. Kuma kafin hakan akwai kwayoyin hana daukar ciki wanda dole ne a sha sau biyu - ba koyaushe dace ba.

Dangane da sake dubawa, Glucofage Long magani ne mai inganci don amfani na dogon lokaci. Ana bayar da rahoton ci gaban sakamako masu illa akai-akai. Tare da wuce haddi mai nauyi, an lura da ragewar hankali.

Wadannan magunguna masu zuwa analog ne na maganin: