Insulin Lantus (Glargine): Gano duk abin da kuke buƙata. A ƙasa zaku sami rubutu cikin yare. Karanta adadin raka'a kana buƙatar shigar da kuma lokacin da, yadda ake lissafin kashi, yadda zaka yi amfani da alkalami na Lantus Solostar. Fahimci tsawon lokacin da allurar wannan magani ya fara aiki, wanda insulin ya fi kyau: Lantus, Levemir ko Tujeo. Yawancin sake dubawa na marasa lafiya da ke da nau'in ciwon sukari na 2 da 1 ana ba su.

Glargin tsohuwar hodar iblis ce wacce kamfanin shahararren kamfanin nan na Sanofi-Aventis ya samar da shi. Wataƙila wannan shine sanannen insulin da ya fara aiki a tsakanin masu ciwon suga da ke magana da Rashanci. Inarƙashinsa yana buƙatar haɓaka tare da hanyoyin magani wanda zai ba ka damar adana sukari na jini 3.9-5.5 mmol / l barga 24 a rana, kamar yadda yake cikin mutane masu lafiya. Tsarin da yake rayuwa tare da ciwon sukari na sama da shekaru 70 yana bawa manya da yara masu fama da ciwon sukari kariya daga cutarwa mai wahala.

Karanta amsoshin tambayoyin:

Dogon insulin Lantus: cikakken labarin

Lura cewa lalataccen insulin Lantus yayi kama da mai kyau. Ta bayyanar miyagun ƙwayoyi ba shi yiwuwa a tantance ingancinsa. Bai kamata ku sayi insulin da magunguna masu tsada daga hannun ku ba, bisa sanarwar sanarwa masu zaman kansu. Samu magungunan cutar sankara daga magunguna masu martaba wadanda ke bin ka'idodin ajiya.

Umarnin don amfani

Lokacin yin allurar Lantus, kamar kowane nau'in insulin, kuna buƙatar bin abinci.

Zaɓuɓɓukan Abincin dangane da cutar:

Yawancin masu ciwon sukari waɗanda ke yin allurar glargine suna ɗaukar abu mai wuya don kauce wa harin hypoglycemia. A zahiri, na iya tsayar da sukari na al'ada har ma da mummunan cutar kansa. Kuma har ma fiye da haka, tare da gwada da laushi kamar nau'in ciwon sukari 2. Babu buƙatar ƙara girman matakin glucose na jini don insure kanka game da haɗarin hypoglycemia. Kalli bidiyon da ke tattauna wannan batun. Koyi yadda za a daidaita abinci mai gina jiki da allurai insulin.

Duba ƙasa don ƙarin bayani.

Lantus magani ne na wane mataki? Dogo ne ko gajeru?

Lantus dogon insulin aiki ne. Kowane allurar wannan miyagun ƙwayoyi yana saukar da sukarin jini cikin awanni 24. Koyaya, allura guda ɗaya a rana bai isa ba. ya bada karfi da bada shawarar yin allurar dogon insulin sau 2 a rana - safe da yamma. Ya yi imanin cewa Lantus yana ƙara haɗarin ciwon kansa, kuma ya fi kyau canzawa zuwa Levemir don guje wa wannan. Duba bidiyo don ƙarin cikakkun bayanai. A lokaci guda, koya yadda ake adana insulin yadda yakamata kada ya lalace.

Wasu mutane, saboda wasu dalilai, suna neman gajeren insulin ɗin da ake kira Lantus. Irin wannan magani ba a kan siyarwa bane kuma bai taɓa kasancewa ba.

Zaku iya allurar insulin da daddare da safe, kuma zaku iya ɗaukar ɗayan magunguna masu zuwa kafin abinci: Actrapid, Humalog, Apidra or NovoRapid. Baya ga abubuwan da ke sama, akwai nau'ikan insulin masu saurin aiki waɗanda aka saki a cikin Federationungiyar Rasha da ƙasashen CIS. Karka yi kokarin maye gurbin injections na gajere ko ultrashort insulin kafin abinci tare da manyan allurai na tsawon lokaci. Wannan zai haifar da ci gaban m, kuma ƙarshe rikice rikice na ciwon sukari.

Karanta game da nau'in insulin mai sauri wanda za'a iya haɗe shi da Lantus:

An yi imani da cewa Lantus bashi da babban matakin aiki, amma yana rage sukari a ko'ina tsawon awanni 18 zuwa 24. Koyaya, yawancin masu ciwon sukari a cikin bita-da-kullinsu a kan mahaɗan suna da'awar cewa har yanzu akwai kololuwa, kodayake mai rauni ne.

Insulin glargine yayi aiki sosai fiye da sauran kwayoyi na matsakaiciyar tsawon lokaci. Koyaya, yana aiki sosai fiye da kima, kuma kowane inje ya doru a kai har zuwa awanni 42. Idan kuɗaɗe sun ba da izini, to, kuyi tunanin maye gurbin Tresib da sabon magani.

Da yawa Lantus raka'a zuwa farashi kuma a yaushe? Yadda ake lissafin kashi?

Mafi kyawun kashi na tsawon insulin, har ma da jadawalin allura, ya danganta ne da halayen hanyar cutar sikari a cikin mara lafiyar. Tambayar da kuka tambaya dole ne a yi bayani daban. Karanta labarin “”. Yi aiki kamar yadda yake a rubuce.

Shirye-shiryen insulin na duniya wanda aka shirya dashi ba zai iya samar da daidaitaccen sukarin jini na yau da kullun ba, koda kuwa mai haƙuri yana da ciwon sukari. Sabili da haka, baya bada shawarar yin amfani da su kuma shafin bai yi rubutu game da su ba.

Harkokin ciwon sukari na insulin - inda zan fara:

Yaushe yafi kyau don tsayar da Lantus: da yamma ko da safe? Shin yana yiwuwa a jinkirta allurar maraice da safe?

Maraice da safiya na insulin insulin ana buƙatar su don dalilai daban-daban. Tambayoyi game da dalilin su da zaɓin sashi ya kamata a magance su dabam da juna. A matsayinka na mai mulkin, mafi yawan lokuta akwai matsaloli tare da sukari na sukari da safe akan komai a ciki. Don dawo da shi zuwa al'ada, yi allura ta tsawan insulin da dare.

Idan mai ciwon sukari yana da matsakaicin matakin glucose na jini da safe akan komai a ciki, to kada ya yi allurar Lantus da dare.

An shirya allurar asuba da safe don kiyaye sukari na yau da kullun a cikin rana cikin komai a ciki. Ba za ku iya gwada maye gurbin allurar da yawa daga cikin miyagun ƙwayoyi Lantus da safe, gabatarwar insulin cikin sauri kafin abinci. Idan sukari yawanci yayi tsalle bayan cin abinci, kuna buƙatar amfani da insulin guda biyu a lokaci guda - tsawaita da sauri. Don sanin idan kuna buƙatar allurar insulin mai tsawo da safe, dole ku ji matsananciyar yunwa don kwana ɗaya ku bi kuzarin matakin glucose a cikin jini.

Ba za a iya jinkirta allurar maraice da safe ba. Idan kun sami sukari mai sanyi da safe akan komai a ciki, kar kuyi ƙoƙarin yanke shi tare da babban adadin dogon insulin. Yi amfani da ɗan gajeren ko shirye-shiryen ultrashort don wannan.Yourara yawan maganin Lantus na cikin maraice da yamma. Don samun sukari na yau da safe a kan komai a ciki, kuna buƙatar cin abincin dare da wuri - 4-5 hours kafin lokacin kwanciya. In ba haka ba, inje na dogon insulin da daddare ba zai taimaka ba, komai girman yadda ake sarrafa su.

Kuna iya samun sauƙin sauƙi akan sauran shafuka masu sauƙi don amfani da insulin Lantus fiye da waɗanda aka koyar. A bisa hukuma, an ba da shawarar bayar da allura guda ɗaya kawai kowace rana.

Koyaya, tsarin kulawa da insulin na wucin gadi baya yin aiki sosai. Masu ciwon sukari da ke amfani da su suna fama da matsanancin yawan ƙwayar cuta da fitsari a cikin sukari na jini. A kwana a tashi, suna haɓaka wannan gajarta rayuwar ko kuma juya mutum zuwa ga nakasassu. Don sarrafa nau'in 1 ko nau'in ciwon sukari 2 da kyau, kuna buƙatar ci gaba, nazarin da yin abin da aka rubuta a ciki.

Menene adadin insulin Lantus a kowace rana?

Babu wani tabbataccen adadin adadin maganin yau da kullun na Lantus insulin. An ba da shawarar a haɓaka shi har sai sukari a cikin jinin mai ciwon sukari ya fi ko ƙasa al'ada.

A cikin mujallolin likita, shari'o'in marasa lafiya masu kiba tare da nau'in ciwon sukari na 2 waɗanda suka karbi raka'a 100-150 na wannan magani kowace rana. Koyaya, mafi girma na yau da kullun, ƙarin matsalolin insulin suna haifar.

Matsayin glucose na ci gaba da tsallewa, sau da yawa akwai hare-haren hypoglycemia. Don guje wa waɗannan matsalolin, kuna buƙatar lura da allurar low insulin, wanda ya yi daidai da shi.

Yakamata maraice da safe na Lantus insulin a zaɓi daban. Ya bambanta sosai dangane da shekaru, nauyin jikin mai haƙuri da tsananin ciwon sukari. Idan kuna buƙatar yin allura sama da raka'a 40 a kowace rana, to kuna yin abin da ba daidai ba. Mafi m, ba tsananin bin low-carb rage cin abinci. Ko ƙoƙarin maye gurbin injections na insulin azumi kafin abinci tare da gabatarwar manyan allurai na glargine na miyagun ƙwayoyi.

Masu fama da kiba fiye da masu ciwon sukari na 2 ana karfafa su sosai don motsa jiki. Yin aiki na jiki zai ƙara ƙwayar hankalin jikin ku zuwa insulin. Wannan zai sa ya yiwu a rarraba tare da matsakaitan magunguna. Tambaye abin da Qi-Gudun yake.

Wasu marasa lafiya suna iya jan ƙarfe a cikin dakin motsa jiki fiye da wasan motsa jiki. Hakanan yana taimakawa.

Insulin lantus da makamantanta analogues. Aikace-aikacen yanayi na musamman da cututtuka na kullum

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Lantus . Yana ba da ra'ayi daga baƙi zuwa shafin - masu amfani da wannan magani, da kuma ra'ayoyin kwararrun likitocin game da amfani da Lantus a cikin al'amuransu. Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Lantus analogues a gaban isassun tsarin analogues. Yi amfani da shi don kula da ciwon sukari-dogara da ciwon sukari mellitus a cikin manya, yara, har ma yayin daukar ciki da lactation. Abun da magani.

Lantus - Alama ce ta insulin mutum. An samu ta hanyar sake haduwa da kwayoyin halittar kwayar halitta ta DNA daga cikin jinsunan Escherichia coli (E. coli) (K12 damuwa). Yana da ƙananan solubility a cikin tsaka tsaki yanayi. A cikin abun da ke ciki na miyagun ƙwayoyi Lantus, yana narkewa gaba ɗaya, wanda yanayin acidic ke tabbatar dashi don maganin allura (pH = 4). Bayan gabatarwar cikin kitse na subcutaneous, mafita, saboda acidityrsa, yana shiga cikin juzu'ikan amsawa tare da samuwar microprecipitates, daga abin da ƙananan ƙwayar insulin glargine (abu mai aiki na shirye-shiryen Lantus) ake fitarwa kullun, yana samar da ingantaccen (ba tare da kololuwa ba) bayanin martaba na lokaci-lokaci, har ma da tsawon lokaci na aikin miyagun ƙwayoyi.

Hanyoyin da ke ɗaurewa ga masu karɓar insulin na insulin glargine da insulin na ɗan adam suna da kusanci.Glulin insulin yana da tasirin kwayar halitta mai kama da insulin halittar jini.

Babban mahimmancin aikin insulin shine tsari na metabolism metabolism. Insulin da analogues dinsu suna rage glucose jini ta hanyar karfafa glucose uptake ta tsokoki na waje (musamman kasusuwa da tsotse nama), tare da hana samuwar glucose a cikin hanta (gluconeogenesis). Insulin yana hana lipolysis adipocyte da proteolysis, yayin inganta haɓakar furotin.

Thearin lokacin aikin insulin glargine shine kai tsaye saboda ƙarancin sha, wanda ke ba da damar amfani da miyagun ƙwayoyi sau ɗaya a rana. Aikin farko a kan matsakaici shine 1 awa bayan sc gwamnati. Matsakaicin tsawon lokacin aiki shine sa'o'i 24, matsakaicin shine sa'o'i 29. Yanayin aikin insulin da analogues ɗin (alal misali, glargine na insulin) akan lokaci na iya bambanta sosai a cikin marassa lafiya daban kuma a cikin haƙuri ɗaya.

Tsawon lokacin da miyagun ƙwayoyi Lantus ya kasance ne saboda gabatarwarsa cikin kitsen subcutaneous.

Insulin glargine + magabata.

Binciken kwatancen na yawan kwantar da hankalin insulin glargine da insulin-isophan bayan gudanarwar subcutaneous a cikin jini a cikin mutane masu lafiya da marasa lafiya da ke dauke da cutar sankarar mahaifa sun bayyana sakin jiki da saurin daukar hankali, da kuma rashin yawan kwarin gwiwa a cikin glargine insulin idan aka kwatanta da insulin-isofan.

Tare da kulawar s / c na miyagun ƙwayoyi 1 lokaci kowace rana, daidaitaccen matsakaiciyar ƙwayar insulin glargine a cikin jini an samu kwanaki 2-4 bayan kashi na farko.

Tare da gudanarwa na ciki, rabin rayuwar insulin glargine da insulin na mutane suna kamantawa.

A cikin mutum a cikin kitse na subcutaneous, insulin glargine an rabu da shi daga motar carbonll (C-terminus) na sarkar B (sarkar beta) don samar da 21A-Gly-insulin da 21A-Gly-des-30B-Thr-insulin. A cikin plasma, glargine insulin da ba ya canzawa da kayan aikin share fage suna nan.

• ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da yara fiye da shekaru 6,
• ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da yara sama da shekaru 2 (don nau'in SoloStar).

Magani don ƙaramar hukumar subcutane (ridarukan katako na mil 3 a OptiSet da kuma allon alkalami na OptiKlik).

Magani don gudanar da aikin ƙarƙashin ƙasa (katako 3 ml a cikin alƙallan siririn Lantus SoloStar).

Umarnin don amfani da makirci na amfani

Lantus OptiSet da OptiKlik

Ana saita adadin maganin da lokacin rana don gudanarwarsa daban-daban. Ana gudanar da Lantus a ƙarƙashin ƙasa sau ɗaya a rana, koyaushe a lokaci guda. Ya kamata a saka Lantus cikin kitse na ciki, kafada ko cinya. Wuraren allurar ya kamata ya canza tare da kowane sabon tsarin magani a cikin wuraren da aka ba da shawarar don maganin kula da miyagun ƙwayoyi.

Za'a iya amfani da maganin a matsayin monotherapy, kuma a hade tare da sauran magungunan hypoglycemic.

Lokacin canja mai haƙuri daga insulins na tsawon lokaci ko matsakaici na aiki zuwa Lantus, yana iya zama mahimmanci don gyara sashin insulin na yau da kullun ko canza maganin antidiabetic (allurai da tsari na gudanarwa na insulins na gajeran lokaci ko analogues, da kuma magungunan maganganu na maganin hypoglycemic).

Lokacin canja mai haƙuri daga tsarin kulawa na insulin-isofan na biyu zuwa allurar guda ɗaya na Lantus, ya kamata a rage kashi na yau da kullun na insal ta hanyar 20-30% a farkon makonni na jiyya don rage haɗarin hauhawar jini a cikin dare da sanyin safiya. A wannan lokacin, rage yawan kashi na Lantus ya kamata a rama shi ta hanyar karuwar adadin insulin na gajeran lokaci, tare da daidaitawar mutum akan tsarin sashi.

Kamar yadda ake yi da sauran analogues na insulin ɗan adam, marassa lafiya da ke karɓar ƙwayoyi masu yawa sakamakon kasancewar ƙwayoyin rigakafi ga insulin na ɗan adam na iya samun karuwa a cikin martanin insulin lokacin da suka sauya sheka zuwa Lantus. Yayin aiwatar da sauyawa zuwa Lantus kuma a cikin farkon makonni bayansa, ana buƙatar saka idanu sosai akan glucose a cikin jini kuma, idan ya cancanta, gyaran hanyoyin sarrafa insulin.

Game da ingantacciyar ƙa'idar aiki na metabolism da kuma sakamakon karuwar haɓakar ƙwaƙwalwar insulin, ƙarin gyaran hanyoyin yin aikin zai iya zama dole. Hakanan ana iya buƙatar daidaita sikelin kashi, alal misali, lokacin canza nauyin mara haƙuri, salon rayuwa, lokacin rana don gudanar da magunguna, ko lokacin da wasu yanayi suka bayyana wanda ke taimakawa ƙara haɓakar tsinkayar ci gaban hauhawar jini ko hauhawar jini.

Bai kamata a gudanar da maganin ba iv. A / a cikin gabatarwar kashi na yau da kullun, wanda aka yi niyya don gudanar da sc, zai iya haifar da ci gaba da rashin ƙarfi na hypoglycemia.

Kafin gudanarwa, dole ne ka tabbata cewa sirinjin ba su da ragowar sauran kwayoyi.

Dokoki don amfani da sarrafa magani

OptiSet alkalannin sirinji da aka riga an cika su

Kafin amfani, bincika katun cikin alkairin sirinji. Yakamata a yi amfani da shi idan mafita a zahiri, mara launi, ba ya ƙunshi abubuwan daskararren abubuwa kuma, cikin daidaito, yayi kama da ruwa. Ba'a amfani da alkalannin sirinji na OptiSet marasa amfani don sake amfani kuma dole ne a hallaka su.

Don hana kamuwa da cuta, alkalami da aka riga aka cika kafin ya yi niyya don amfani da mai haƙuri ɗaya kuma ba za'a iya tura shi ga wani ba.

Mu'amala da OptiSet Syringe Pen

Don kowane amfani da zai biyo baya, yi amfani da sabon allura. Yi amfani da allura kawai waɗanda suka dace don alkalami na OptiSet.

Kafin kowane allura, yakamata a yi gwajin lafiya.

Idan aka yi amfani da sabon sirinji na OptiSet, ya kamata ayi amfani da shiri don amfani da gwajin ta amfani da rukunin 8 wanda masana'antun suka zaɓa.

Za'a iya jujjuya wa mai zaɓin sashi gwargwado.

Karka taɓa juya mai zaɓin kashi (canjin kashi) bayan danna maɓallin fara allura.

Idan wani mutum ya yi allura ga mai haƙuri, dole ne a kula da kulawa ta musamman don guje wa rauni na allura da kamuwa da cuta ta hanyar ƙwayar cuta.

Karka taɓa amfani da alkalami mai rauni na OptiSet da ya lalace, haka nan kuma idan ana zargin ɓarnar aiki.

Wajibi ne a sami ɗan hular OptiSet syringe na dabam idan an yi asara ko lalacewar wanda aka yi amfani dashi.

Bayan cire hula daga alkairin sirinji, bincika alamar akan ɗakin insulin don tabbatar da cewa ya ƙunshi insulin da ya dace. Ya kamata kuma a tabbatar da bayyanar insulin: maganin insulin yakamata ya zama sananne, mara launi, babu 'yankar daskararren abu mai kyau kuma yana da daidaito kamar ruwa. Kada ku yi amfani da alkalami na OptiSet idan maganin insulin yana da gajimare, ƙaiƙayi ko ya ƙunshi barbashi na kasashen waje.

Bayan cire murfin, a hankali kuma ka haɗa allura da alkalami na syringe.

Dubawa da shirye-shiryen alkairin sirinji don amfani

Kafin kowane allura, ya zama dole a duba shirye-shiryen alkairin sirinji don amfani.

Don sabon alkalami da ba a amfani dashi, mai nuna alamar ya kamata ya kasance a lamba 8, kamar yadda masana'anta suka saita.

Idan aka yi amfani da alkalami mai sirinji, mai watsa abin ya kamata a juya har sai alamar man ta tsaya a lamba 2. Mai nuna zai juya ta hanya daya kawai.

Ullissar maɓallin farawa gaba ɗaya don amfani. Kada a juya mai zaɓin kashi bayan an cire maɓallin farawa.

Dole ne a cire ƙananan ƙofofin allura na ciki da ciki. Ajiye murfin waje don cire allura da aka yi amfani da shi.

Yayin riƙe alkalami na syringe tare da allura yana nuna sama, a hankali matsi da insulin cikin yatsanka don iska kuzarin sama ya tashi zuwa allura.

Bayan haka, danna maɓallin farawa koyaushe.

Idan digo na insulin ya fito daga tip na allura, alkalami mai aiki da allura suna aiki daidai.

Idan digo na insulin bai bayyana ba a saman allura, ya kamata ku maimaita gwajin shiri na alkairin sirinji don amfani har sai insulin ta bayyana a saman allura.

Zaɓi na insulin kashi

Ana iya saita kashi 2 zuwa raka'a 40 a cikin karin raka'a 2. Idan ana buƙatar sashin da ya wuce raka'a 40, dole ne a gudanar dashi a cikin allura biyu ko fiye. Tabbatar kana da isasshen insulin don maganin ka.

Matsakaicin insulin mai saura akan kwandon shara don insulin yana nuna yadda kusan insulin ya rage a cikin ƙwayar sirinji ta OptiSet. Ba za a iya amfani da wannan sikelin don ɗaukar kashi na insulin ba.

Idan fistin baƙar fata yana farkon farkon tsiri mai launin, to, akwai kusan raka'a 40 na insulin.

Idan piston na baki yana ƙarshen ƙarshen tsiri mai launin to, akwai kimanin raka'a 20 na insulin.

Ya kamata a juya mai amfani da kashi har sai kibiya ta nuna alamar da ake so.

Insulin kashi na ci

Dole a jawo maɓallin farawa allurar zuwa iyaka don cika alkalami insulin.

Ya kamata a bincika ko kashi da ake so an tattara tarawa. Maɓallin farawa yana canzawa daidai da yawan insulin da ya rage a cikin tanlin insulin.

Maɓallin farawa yana ba ku damar bincika wane kashi ake kira. A yayin gwajin, dole ne a kiyaye maballin farawa. Layin ƙarshe da aka gani na ƙarshe akan maɓallin farawa yana nuna adadin insulin ɗin da aka ɗauka. Lokacin da aka riƙe maɓallin farawa, kawai saman wannan layin yana bayyane.

Personnelwararrun ƙwararrun ma'aikata ya kamata su bayyana dabarar allura ga mai haƙuri.

Allurar tana cikin allurar ƙarƙashin ƙasa. Ya kamata a matsi maɓallin fara allurar zuwa iyaka. Danna maɓallin dannawa zai tsaya lokacin da aka danna maɓallin fara allura duk yadda yakamata. Sannan, ya kamata a adana maɓallin fara allura har tsawan 10 kafin cire allura daga cikin fata. Wannan zai tabbatar da gabatarwar dukkan kashi na insulin.

Bayan kowace allura, sai a cire allura daga sirinji ya watsar. Wannan zai hana kamuwa da cuta, da kuma yaduwar insulin, da yawan iska da kuma yiwuwar toshewar allura. Ba za a iya sake amfani da allura ba.

Bayan haka, sa a kan hat don alkalami mai sirinji.

Ya kamata a yi amfani da katako tare da alkalami na OptiPen Pro1, kuma ya dace da shawarwarin da masana'antun na'urar suka bayar.

Umarnin don yin amfani da alkalami na OptiPen Pro1 game da shigarwa na katako, abin da aka makala allura, da allurar insulin ya kamata a bi daidai. Binciken katun kafin amfani. Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani. Kafin shigar da katun a cikin alkairin sirinji, ya kamata kabad ɗin ya kasance cikin zazzabi a ɗakin don awa 1-2. Kafin yin allura, cire kumburin iska daga kicin. Wajibi ne a bi umarnin sosai. Ba a sake amfani da akwatunan komai ba. Idan alkairin OptiPen Pro1 ya lalace, dole ne kar kuyi amfani da shi.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar tattara maganin daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Tsarin Kayan Tsarin Kaya

Tsarin katako na OptiClick shine katako mai gilashi wanda ke dauke da 3 ml na glargine bayani na insulin, wanda aka sanya shi cikin kwandon filastik mai ma'ana tare da kayan piston mai haɗe.

Ya kamata a yi amfani da tsarin kabad ɗin OptiClick tare da alkalami na OptiClick mai dacewa tare da umarnin yin amfani da shi.

Idan alkairin OptiClick ya lalace, maye gurbinsa da sabon.

Kafin shigar da tsarin katun a cikin alkalami na OptiClick, yakamata ya kasance a zazzabi a cikin ɗakuna na 1-2 hours. Ya kamata a bincika tsarin katun kafin shigarwa.Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani. Kafin yin allura, cire kumburin iska daga tsarin katun (kamar dai ta amfani da alƙaluma mai kaɗa). Ba a sake amfani da tsarin akwatinan fanko ba.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar rubuta mafita daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Don hana kamuwa da cuta, mutum ɗaya ne kawai yakamata ya yi amfani da alkalami na sake amfani da maimaitawa.

Lantus SoloStar ya kamata a gudanar da subcutaneously sau ɗaya a rana a kowane lokaci na rana, amma kowace rana a lokaci guda.

A cikin marasa lafiya da nau'in ciwon sukari na 2 na sukari, ana iya amfani da Lantus SoloStar a matsayin monotherapy kuma a hade tare da sauran magungunan hypoglycemic. Ya kamata a tantance abubuwan da ke tattare da glucose na jini, kazalika da allurai da lokacin gudanarwa ko gudanar da magunguna na hypoglycemic kuma a daidaita su daban-daban.

Hakanan ana iya buƙatar daidaita daidaituwa, misali, lokacin canza nauyin mara haƙuri, salon rayuwa, canza lokacin gudanarwa na kashi na insulin, ko a wasu yanayi waɗanda zasu iya ƙara tsinkaye zuwa haɓakar hypo-ko hyperglycemia. Duk wani canje-canje a cikin adadin insulin ya kamata a aiwatar da shi tare da taka tsantsan kuma a ƙarƙashin kulawar likita.

Lantus SoloStar ba insulin zaɓi bane don warkar da cutar ketoacidosis mai ciwon sukari. A wannan halin, zaɓi ya kamata a gabatar da / a cikin gabatarwar insulin gajere. A cikin tsarin kulawa tare da injections na basal da prandial insulin, kashi 40-60% na yau da kullun na insulin a cikin nau'in insulin glargine yawanci ana gudanar da shi don biyan bukatar insulin basal.

A cikin marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na mellitus suna ɗaukar magunguna na hypoglycemic don sarrafa bakin, maganin haɗin gwiwa yana farawa da kashi na insulin glargine 10 KUDI 1 sau ɗaya kowace rana kuma a cikin tsarin kulawa na gaba yana daidaita daidaituwa.

Canji daga jiyya tare da wasu magungunan cututtukan jini zuwa Lantus SoloStar

Lokacin canja mai haƙuri daga tsarin kulawa ta amfani da matsakaiciyar matsakaici ko tsawon lokacin aiki zuwa insimen magani ta amfani da shirye-shiryen Lantus SoloStar, yana iya zama dole don daidaita lamba (allurai) da lokacin gudanar da insulin gajere-gajeren lokaci ko kuma analog a cikin rana ko canza allurai na maganin ƙwaƙwalwar ƙwayar cuta.

Lokacin canja wurin marasa lafiya daga allura guda na insulin-isofan yayin rana zuwa guda na gudanar da magani a cikin rana, Lantus SoloStar baya canza yanayin farkon insulin (i.e., adadin Lantus SoloStar Units a kowace rana daidai yake da adadin ME insulin isofan kowace rana).

Lokacin canja wurin marasa lafiya daga gudanar da insulin-isophan sau biyu a rana zuwa guda allurar Lantus SoloStar kafin lokacin bacci don rage haɗarin hauhawar jini a cikin dare da farkon sa'o'i, farawa na yau da kullun na insulin glargine yawanci an rage shi da 20% (idan aka kwatanta da yau da kullun na insulin isophane), sannan a daidaita shi gwargwadon amsawar mara lafiyan.

Kada a cakuda Lantus SoloStar ko a cakuda shi da sauran shirye-shiryen insulin. Tabbatar cewa sirinjin ba ya ƙunsar sauran sauran ƙwayoyi. Lokacin haɗuwa ko tsarma, bayanin martaba na insulin glargine na iya canzawa akan lokaci.

Lokacin canzawa daga insulin mutum zuwa magani Lantus SoloStar kuma a cikin makonni na farko bayan shi, ana ba da kulawa mai kulawa da hankali (lura da yawan tasirin glucose a cikin jini) a ƙarƙashin kulawar likita, tare da gyara hanyoyin sarrafa insulin idan ya zama dole.Kamar yadda yake tare da wasu analogues na insulin ɗan adam, wannan gaskiya ne ga marasa lafiya waɗanda, saboda kasancewar ƙwayoyin rigakafi ga insulin ɗan adam, suna buƙatar yin amfani da babban insulin na mutum. A cikin irin waɗannan marasa lafiya, lokacin amfani da glargine na insulin, ana iya lura da ingantacciyar ci gaba game da martanin da zai shafi kulawar insulin.

Tare da ingantacciyar iko na sarrafawa da kuma haifar da karuwar jijiyoyin jiki zuwa insulin, yana iya zama dole don daidaita tsarin sashi na insulin.

Hadawa da kiwo

Kada a cakuda miyagun ƙwayoyi Lantus SoloStar tare da wasu insulins. Haɗawa na iya canza rabo na lokaci / sakamako na miyagun ƙwayoyi Lantus SoloStar, kazalika da haifar da hazo.

Groupsungiyoyin haƙuri na musamman

Ana iya amfani da miyagun ƙwayoyi Lantus SoloStar a cikin yara da suka girmi shekaru 2. Ba a yi amfani da amfani da yara a ƙarƙashin shekaru 2 ba.

A cikin tsofaffi marasa lafiya da masu ciwon sukari mellitus, ana bada shawarar yin amfani da allurai na farko matsakaici, jinkirin karuwarsu da kuma amfani da matsakaitattun matakan kulawa.

Ana amfani da miyagun ƙwayoyi Lantus SoloStar a matsayin allurar sc. Magungunan Lantus SoloStar ba an yi shi bane don gudanarwar jijiya.

Tsawon lokacin aikin insulin glargine ana lura dashi ne kawai lokacin da aka gabatar dashi cikin mai mai kitse. A / a cikin gabatarwar kashi na biyu subcutaneous kashi na iya haifar da mummunan hypoglycemia. Ya kamata a gabatar da Lantus SoloStar cikin kitse na cikin ciki, kafadu ko kwatangwalo. Wuraren allurar ya kamata ya canza tare da kowane sabon allura a cikin wuraren da aka ba da shawarar don kamfani na maganin. Kamar yadda yake dangane da sauran nau'ikan insulin, matakin sha, kuma, sakamakon haka, farawa da tsawon lokacin aikinsa, na iya bambanta ƙarƙashin tasirin ayyukan jiki da sauran canje-canje a yanayin mai haƙuri.

Lantus SoloStar bayani ne bayyananne, ba dakatarwa ba. Saboda haka, sake tayardawa kafin amfani ba a buƙatar. Idan ƙwayar sikiran Lantus SoloStar ba ta da matsala, ana iya cire gulingine insulin daga cikin katun a cikin sirinji (wanda ya dace da insulin 100 IU / ml) kuma a yi allurar da ta dace.

Sharuɗɗa don amfani da sarrafa alƙalami mai cike da farashi SoloStar

Kafin amfani na farko, dole ne a kiyaye alƙalin sirinji a zafin jiki a cikin 1-2 na sa'o'i 1-2.

Kafin amfani, bincika katun cikin alkairin sirinji. Yakamata a yi amfani da shi idan mafita a zahiri, mara launi, ba ya ƙunshi abubuwan daskararren abubuwa kuma, cikin daidaito, yayi kama da ruwa.

Ba a sake amfani da sirinjin SoloStar ba kuma dole ne a zubar dashi.

Don hana kamuwa da cuta, alƙalami guda ɗaya ya kamata yakamata ya yi amfani da shi kuma ba za a tura shi ga wani ba.

Kafin amfani da alƙalaran sirinji na SoloStar, karanta bayanan a hankali akan amfani.

Kafin kowane amfani, a hankali haɗa sabon allura zuwa maɓallin sirinji kuma gudanar da gwajin lafiya. Dole ne kawai a yi amfani da allura da suka dace da SoloStar.

Dole a yi taka tsantsan don kiyaye haɗari da ya shafi amfani da allura da kuma yiwuwar kamuwa da cuta.

A kowane hali ya kamata ku yi amfani da alkairin sirinjin SoloStar idan ya lalace ko kuma ba ku san cewa zai yi aiki yadda yakamata ba.

Kullum koyaushe kuna da alƙalaran alƙalami na sifofin SoloStar a hannu idan kun rasa ko lalata kwafin silsilar SoloStar da ke akwai.

Idan an adana allurar sirinjin SoloStar a cikin firiji, ya kamata a fitar da shi 1-2 hours kafin allurar da aka yi niyya don maganin zai iya ɗaukar zazzabi a ɗakin. Gudanar da insulin mai narkewa shine mafi zafi. Dole ne a lalata alkairin sirinji SoloStar da aka yi amfani dashi.

Dole ne a kiyaye alkairin sirinjin SoloStar daga ƙura da datti.Ana iya tsabtace waje na alkairin SoloStar sirinji ta hanyar goge shi da rigar rigar. Kada a nutsar a cikin ruwa, a matse kuma a sa mai alkairin SoloStar sirinji, domin wannan na iya lalata shi.

Alƙalin sirinji na SoloStar yayi daidai insulin insulin kuma yana da aminci don amfani. Hakanan yana buƙatar kulawa da hankali. Guji yanayi wanda lalacewar alƙawarin Silinsar SoloStar na iya faruwa. Idan kuna tsammanin lalacewar yanayin data kasance na alƙalmar sirinjin SoloStar, yi amfani da sabon alkalami na sirinji.

Mataki na 1. Kula da insulin

Kuna buƙatar bincika lakabin akan allon alkairin SoloStar don tabbatar da cewa ya ƙunshi insulin da ya dace. Don Lantus, alkalami na sirinji na SoloStar ya yi launin toka tare da maɓallin shunayya don yin allura. Bayan an cire maƙarƙen siririn sirinji, bayyanar insulin da ke ciki ana sarrafa shi: maganin insulin dole ne ya zama mai ma'ana, mara launi, ba ya ƙunshi isassun barbashi mai bayyane mai kama da ruwa mai daidaituwa.

Mataki na 2. Haɗa allura

Yi amfani kawai da allura da suka dace da SoloStar Syringe Pen. Don kowane allurar da ta biyo baya, koyaushe yi amfani da sabon allurar bakararre. Bayan cire hula, dole a saka allura a hankali akan almalin syringe.

Mataki na 3. Yin gwajin aminci

Kafin kowane allura, ya zama dole a gudanar da gwajin aminci kuma a tabbata cewa alƙalin sirinji da allura suna aiki sosai kuma an cire kumburin iska.

Auna kashi daya daidai da raka'a 2.

Dole ne a cire ƙananan ƙofofin allura na ciki da ciki.

Sanya alƙalin sirinji tare da allura sama, a hankali a matattar ƙwalin insulin tare da yatsanka don duk an nuna kumburin iska zuwa allura.

A latsa maɓallin allurar gabaɗaya.

Idan insulin ya bayyana a saman allura, wannan yana nufin cewa alkalami mai kaɗa da allura suna aiki daidai.

Idan insulin bai bayyana ba a saman allura, to za a iya maimaita mataki na 3 har sai insulin ta bayyana a saman allura.

Mataki 4. Yankan Sashi

Ana iya saita kashi tare da daidaito na 1 naúrar daga mafi ƙarancin (1 raka'a) zuwa matsakaicin adadin (raka'a 80). Idan ya zama dole a gabatar da kaso fiye da raka'a 80, to dole ne a bayar da 2 allurai

Wutar taga zata nuna “0” bayan kammala gwajin amincin. Bayan wannan, ana iya kafa kashi mai mahimmanci.

Mataki 5. Allura

Yakamata a sanar da mara lafiyar game da dabarar allura ta kwararrun likitoci.

Dole ne a saka allura a ƙarƙashin fata.

Ya kamata a matsi maɓallin allurar gabaɗaya. Ana riƙe shi a wannan matsayin na wani sakan 10 har sai an cire allura. Wannan yana tabbatar da gabatarwar kashi da aka zaɓa na insulin gabaɗaya.

Mataki 6. Ana cire da zubar da allura

A kowane hali, ya kamata a cire cire allurar bayan kowane allura. Wannan yana tabbatar da hana rigakafin cuta da / ko kamuwa da cuta, iska da ke shiga cikin akwati don insulin da yaduwar insulin.

Lokacin cirewa da zubar da allura, dole ne a yi taka-tsantsan taka tsan-tsan. Bi matakan da aka bayar na kariya na tsaro don cirewa da fitar da allura (alal misali, hanyar dabarar hannu ɗaya) don rage haɗarin haɗarin haɗari da allura da kuma hana kamuwa da cuta.

Bayan cire allura, rufe allon alkairin SoloStar da hula.

• hypoglycemia - yana haɓaka mafi yawan lokuta idan kashi na insulin ya wuce buƙatarta,
• "mara nauyi" sani ko asarar,
• cututtukan zuciya
• yunwa
• haushi
• gumi mai sanyi
• samarin
• karancin gani
• ma'asumi
• lipodystrophy,
• dysgeusia,
• myalgia
• kumburi
• halayen rashin lafiyan kai tsaye ga insulin (gami da sinadarin insulin glargine) ko kayan taimako na magunguna: jigilar fatar fata, angioedema, bronchospasm, jijiyoyin jini, tsawa,
• jan, ciwo, itching, amya, kumburi ko kumburi a wurin allurar.

• yara 'yan kasa da shekaru 6 don Lantus OptiSet da OptiKlik (a halin yanzu babu bayanan asibiti game da amfanin),
• shekarun yara har zuwa shekaru biyu na Lantus SoloStar (rashin bayanan asibiti game da amfani),
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Haihuwa da lactation

Tare da taka tsantsan, ya kamata a yi amfani da Lantus yayin daukar ciki.

Ga marasa lafiya da ke fama da cutar sankarar bargo ta haihuwa ko ta gestational, yana da muhimmanci a kula da ka’ida sosai a duk lokacin daukar ciki. A cikin watanni 1 na ciki na ciki, buƙatar insulin na iya raguwa, a cikin watanni na 2 da na 3 yana iya ƙaruwa. Nan da nan bayan haihuwa, buƙatar insulin ya ragu, sabili da haka haɗarin hauhawar jini yana ƙaruwa. A ƙarƙashin waɗannan yanayin, saka idanu a hankali game da glucose jini yana da mahimmanci.

A cikin nazarin dabbobi na gwaji, ba a sami bayanai na kai tsaye ko a kaikaice game da embryotoxic ko tasirin maganin insulin glargine ba.

Ba a sami gwajin gwajin asibiti ba na amincin miyagun ƙwayoyi Lantus yayin daukar ciki. Akwai shaidar amfani da Lantus a cikin mata masu ciki 100 masu ciwon sukari. Hanya da sakamako na ciki a cikin waɗannan marasa lafiya bai bambanta da waɗanda ke cikin mata masu juna biyu da masu ciwon sukari waɗanda suka sami sauran shirye-shiryen insulin.

A cikin mata yayin shayarwa, ana iya buƙatar gyaran insulin na tsarin insulin da abinci.

Yi amfani da yara

A halin yanzu babu bayanan asibiti game da amfanin a cikin yara 'yan ƙasa da shekaru shida.

Yi amfani da shi a cikin tsofaffi marasa lafiya

A cikin marasa lafiya tsofaffi, ci gaba mai lalacewa a cikin aikin koda na iya haifar da raguwa a cikin buƙatun insulin.

Lantus ba magani bane na zaɓin ketoacidosis na masu ciwon sukari. A irin waɗannan halaye, ana bada shawarar gudanar da aikin insulin na ɗan gajeran lokaci.

Sakamakon ƙarancin ƙwarewa tare da Lantus, ba zai yiwu a kimanta ƙimar ta da amincin kulawa da kula da marasa lafiyar da ke fama da cutar hanta ko marasa lafiya da ƙarancin rashin ƙarfi na koda.

A cikin marasa lafiya da ke fama da rauni aiki, bukatar insulin na iya raguwa saboda raunin tsarin kawar dashi. A cikin marasa lafiya tsofaffi, ci gaba mai lalacewa a cikin aikin koda na iya haifar da raguwa a cikin buƙatun insulin.

A cikin marasa lafiya da rashin isasshen hepatic, ana iya rage buƙatar insulin saboda raguwa a cikin ikon gluconeogenesis da biotransformation na insulin.

Dangane da rashin iya sarrafawa dangane da matakin glucose a cikin jini, haka kuma idan akwai wani ra’ayi na haɓaka hypo- ko hyperglycemia, kafin a ci gaba da aiwatar da tsarin magunguna, ya zama dole a bincika daidaiton yarda da tsarin kulawar da aka tsara, wuraren gudanar da magunguna da fasahar ƙwararrun allura. , yin la’akari da duk dalilai masu tasiri a kansa.

Lokacin haɓakawar hypoglycemia ya dogara da bayanin aikin aikin insulin da aka yi amfani dashi kuma saboda haka, ya canza tare da canji a tsarin kulawa. Sakamakon ƙaruwa a cikin lokacin da yake ɗauka don gudanar da aikin insulin na dogon lokaci lokacin amfani da Lantus, mutum yakamata yai tsammanin ƙananan yiwuwar haɓakar ƙonewar dare, alhali a farkon sa'o'in safiya wannan yiwuwar yana da girma. Idan hypoglycemia ya faru a cikin marasa lafiya da ke karɓar Lantus, yiwuwar rage gudu daga hypoglycemia saboda tsawan aikin insulin glargine ya kamata a yi la'akari.

A cikin marasa lafiya waɗanda a cikinsu sassan cututtukan hypoglycemia na iya samun ƙimar musamman na asibiti, gami da tare da matsanancin rauni na cututtukan hanji ko na jijiyoyin wuya (hadarin haɓaka bugun zuciya da rikicewar cututtukan ƙwayar cuta), kazalika da marasa lafiya tare da farfadowa na ƙwayar cuta, musamman idan ba su karɓar magani na hoto ba (haɗarin rushewar hangen nesa na ɓoyewar jini), ya kamata a lura da kulawa ta musamman kuma a kula sosai. jini.

Yakamata a gargadi marassa lafiya game da yanayi wanda alamomin bayyanar cututtukan hawan jini na iya raguwa, zama mara karfi ko kuma ba su cikin wasu rukunin hadarin, wadanda suka hada da:

• marasa lafiya waɗanda ke da tabbas ingantaccen tsari na glucose jini,
• marasa lafiya waɗanda ke inganta hypoglycemia a hankali
• tsofaffi marasa lafiya
• masu cutar neuropathy
• marasa lafiya da doguwar cutar sankarau,
• marasa lafiya da matsalar rashin hankalin
• marasa lafiya sun canza daga insulin na asalin dabba zuwa insulin na mutum,
• marasa lafiya da ke karbar magani tare da wasu kwayoyi.

Irin waɗannan yanayi na iya haifar da haɓakar rashin ƙarfi na hypoglycemia (tare da yiwuwar asarar hankali) kafin mai haƙuri ya fahimci cewa yana haɓaka hypoglycemia.

Idan aka lura da al'ada ko aka rage matakan haemoglobin, yana da muhimmanci a la'akari da yuwuwar haɓakar sabon yanayin tashin hankali wanda bai dace ba (musamman da daddare).

Yarda da haƙuri game da dosing regimens, abinci, da rage cin abinci, insulin amfani, da kuma sarrafa farkon bayyanar cututtuka na hypoglycemia na taimaka wajan rage raguwa cikin haɗarin haɗarin hauhawar jini. A gaban abubuwan da ke haifar da haɓakar haɗarin jini, musamman lura da hankali dole ne, saboda Ana iya buƙatar daidaita sirin insulin sashi. Wadannan abubuwan sun hada da:

• canza wurin gudanar da insulin,
• sensara ji da hankali ga insulin (alal misali, lokacin da ake kawar da abubuwan damuwa),
• sabon abu, ƙara ko tsawan aiki na jiki,
• cututtuka daga ciki tare da amai, gudawa,
• take hakkin abinci da abinci,
• Abinci mai tsallakewa
• shan giya
• wasu rikice-rikice na ungenshy endocrine (alal misali, hypothyroidism, karancin adenohypophysis ko adrenal cortex),
• gamsar da magani tare da wasu magunguna.

A cikin cututtukan cututtukan zuciya, ana buƙatar ƙarin kulawa da glucose jini. A yawancin lokuta, ana yin bincike don kasancewar jikin ketone a cikin fitsari, kuma ana buƙatar gyaran sashi na insulin na insulin koda yaushe. Bukatar insulin sau da yawa yana ƙaruwa. Marasa lafiya da ke ɗauke da ciwon sukari na 1 ya kamata su ci gaba da cinye aƙalla kaɗan na ƙwayoyin carbohydrates, koda lokacin cin abinci kawai a cikin ƙananan kima ko kuma a cikin rashin iya cin abinci, tare da amai. Wadannan marasa lafiya kada su daina sarrafa insulin.

Oral hypoglycemic jami'ai, ACE inhibitors, rashin biyayya, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, dextropropoxyphene, salicylates da maganin antioxidam na sulfonamide na iya haɓaka tasirin rashin lafiyar insulin da ƙara haɓakar yanayin ci gaban hauhawar jini. Tare da waɗannan haɗuwa, za'a iya buƙatar daidaita sashin insulin glargine.

Glucocorticosteroids (GCS), danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, phenothiazine derivatives, somatotropin, sympathomimetics (misali epinephrine, salbutamol, terbutaline), hormones, cinema, cinema ) na iya rage tasirin insulin.Tare da waɗannan haɗuwa, za'a iya buƙatar daidaita sashin insulin glargine.

Tare da amfani da miyagun ƙwayoyi na Lantus a lokaci guda tare da beta-blockers, clonidine, salhi na lithium, ethanol (barasa), duka haɓaka da raguwa a cikin tasirin hypoglycemic na insulin yana yiwuwa. Pentamidine lokacin da aka haɗo shi da insulin zai iya haifar da hypoglycemia, wanda wasu lokuta ana maye gurbinsu da hyperglycemia.

Tare da yin amfani da lokaci ɗaya tare da kwayoyi tare da sakamako na juyayi, kamar beta-blockers, clonidine, guanfacine da reserpine, raguwa ko rashi alamun alamun adrenergic counterregulation (kunnawa tsarin juyayi na juyayi) tare da haɓaka ƙarancin jini zai yiwu.

Kada a haɗo Lantus tare da sauran shirye-shiryen insulin, tare da wasu magunguna, ko kuma an lalata Lokacin haɗawa ko tsarma, bayanin ayyukansa na iya canzawa na tsawon lokaci, ƙari, haɗawa da wasu abubuwan insulins na iya haifar da hazo.

Analogues na miyagun ƙwayoyi Lantus

Tsarin analogues na mai aiki abu:

• Insulin glargine,
• Lantus SoloStar.

Analogs don tasirin warkewa (kwayoyi don lura da ciwon sukari na dogaro da sukari-mellitus):

• Aiki
• Anvistat
• Apidra
• B. Insulin
• Berlinsulin,
• Biosulin
• Glyformin
• Glucobay,
• Asarar insulin C,
• Dibikor
• Isofan insulin Gasar Cin Kofin Duniya,
• Iletin
• Insulin Isofanicum,
• Tekin insulin,
• Insulin Maxirapid B,
• Matsakaici insulin
• Insulin kwalliya,
• Insulin Ultralente,
• Insulin mai tsawo
• Insulin Alkairi,
• Insuman
• Intal
• Hadarin insulin C
• Levemir Penfill,
• Levemir Flexpen,
• Metformin
• Mikstard
• Monosuinsulin MK,
• Monotard
• NovoMiks,
• Lantakiya,
• Pensulin,
• Protafan
• Rinsulin
• Stylamine
• Thorvacard
• Tricor
• Ultratard
• Humalog,
• Humulin
• Harshen Cigapan
• Erbisol.

Idan babu analogues na miyagun ƙwayoyi don ƙwayar abu mai aiki, zaku iya danna hanyoyin da ke ƙasa zuwa cututtukan da maganin da ya dace ya taimaka daga kuma duba magungunan analogues na maganin warkewa.

Insulin Lantus (Glargine): Gano duk abin da kuke buƙata. A ƙasa zaku sami rubutu cikin yare. Karanta adadin raka'a kana buƙatar shigar da kuma lokacin da, yadda ake lissafin kashi, yadda zaka yi amfani da alkalami na Lantus Solostar. Fahimci tsawon lokacin da allurar wannan magani ya fara aiki, wanda insulin ya fi kyau: Lantus, Levemir ko Tujeo. Yawancin sake dubawa na marasa lafiya da ke da nau'in ciwon sukari na 2 da 1 ana ba su.

Glargin tsohuwar hodar iblis ce wacce kamfanin shahararren kamfanin nan na Sanofi-Aventis ya samar da shi. Wataƙila wannan shine sanannen insulin da ya fara aiki a tsakanin masu ciwon suga da ke magana da Rashanci. Inarƙashinsa yana buƙatar haɓaka tare da hanyoyin magani wanda zai ba ka damar adana sukari na jini 3.9-5.5 mmol / l barga 24 a rana, kamar yadda yake cikin mutane masu lafiya. Tsarin da yake rayuwa tare da ciwon sukari na sama da shekaru 70 yana bawa manya da yara masu fama da ciwon sukari kariya daga cutarwa mai wahala.

Karanta amsoshin tambayoyin:

Dogon insulin Lantus: cikakken labarin

Lura cewa lalataccen insulin Lantus yayi kama da mai kyau. Ta bayyanar miyagun ƙwayoyi ba shi yiwuwa a tantance ingancinsa. Bai kamata ku sayi insulin da magunguna masu tsada daga hannun ku ba, bisa sanarwar sanarwa masu zaman kansu. Samu magungunan cutar sankara daga magunguna masu martaba wadanda ke bin ka'idodin ajiya.

Yin amfani da miyagun ƙwayoyi Lantus

Ana gudanar da S / c zuwa yankin bangon ciki na ciki, tsoka ko ƙashin cinya sau ɗaya a rana, a lokaci guda. An saita kashi akayi daban-daban. Don gudanar da maganin, magungunan sirinji kawai a 100 IU dole ne a yi amfani da su! Ba za a iya shigar da Lantus cikin / ciki ba, tunda gabatarwar a cikin kashi na yau da kullun don sc gudanarwar zai iya haifar da ci gaba da cututtukan hypoglycemia mai ƙarfi. Kada a cakuda Lantus tare da wani insulin ko kuma mai nishi, saboda wannan na iya canza lokaci / yanayin miyagun ƙwayoyi kuma zai haifar da haifar da laka.
A cikin marasa lafiya da nau'in ciwon sukari na II na mellitus, ana iya amfani da Lantus lokaci guda tare da wakilai na hypoglycemic na bakin, a wannan yanayin, matsakaicin matakin farko na Lantus shine 10 IU / day, daga 2 zuwa 100 IU / rana.
Canji daga wasu insulin. Lokacin canzawa daga insulin tare da matsakaicin tsawon lokacin aiki ko daga insulin aiki na dogon lokaci zuwa Lantus, za'a iya samun buƙatar daidaita sashi na insal na basal, da kuma canji a cikin tsarin kwalliyar ƙwayar maganganu na bakin jini, analolo na gajeran aiki analogues.
Don rage haɗarin rashin lafiyar hypglycemia ko hypoglycemia a farkon safiya, marasa lafiya waɗanda aka canza su daga sau biyu suna ba da insulin na mutum zuwa Lantus 1 lokaci kowace rana suna buƙatar rage kashi na insulin na asali ta 20-30% a cikin makonni na farko na magani. Irin wannan raguwa a cikin adadin insulin na asali ya kamata a kashe shi na ɗan lokaci ta wani ƙaruwa a cikin kashi na insulin wanda aka sarrafa tare da abinci. A ƙarshen lokacin shiri, ana sake gyaran allurai na insulin.
Kamar yadda yake tare da wasu analogues na insulin, a cikin marasa lafiya waɗanda ke karɓar ƙwayar insulin sosai saboda kasancewar ƙwayoyin rigakafi ga insulin na mutum, yana yiwuwa inganta haɓakar mayar da martani ga insulin yayin maganin tare da Lantus SoloStar, wanda ke buƙatar daidaita sashi. Wannan yana da mahimmanci musamman a la'akari da marasa lafiya da masu kiba, tare da canza salon rayuwa.
Ana gudanar da Lantus s / c sau ɗaya a rana, a lokaci guda, a cikin kashi da aka zaɓa da akayi daban-daban.
Alƙalin sirinji yana ba ku damar shigar da ƙwayar ƙwayar cuta a cikin kewayon kashi ɗaya daga 2 zuwa 40 IU. Ba za a iya shigar da miyagun ƙwayoyi cikin / ciki ba, tunda gabatarwar kashi na yau da kullun a cikin wannan yanayin yana iya haifar da ci gaba da hauhawar jini.
Babu bambance-bambance na asibiti a cikin insulin plasma ko matakan glucose bayan gudanar da magani ga bangon ciki, tsoka ko cinya. Za'a iya canza wurin allurar a cikin da'irar.
Zai yuwu amfani da maganin kawai idan maganin a lokacin gwaji na gani ya kasance m da mara launi (ko kuma a zahiri mara launi), ba tare da barbashi da ido ba. Nan da nan kafin allurar, cire kumburin iska daga sirinji. Ba a yarda da hada magungunan ba tare da wasu jami'ai, saboda wannan na iya haifar da haifar da hazo. Kowane lokaci don yin allura, yi amfani da sabon allura zuwa alkairin syringe. Bayan allura, dole ne a cire allura kuma an adana allurar sirinji ba tare da allura ba.
Babu buƙatar girgiza alkalami kafin amfani. Kafin amfani da shi, dole ne a riƙe alkalami mai siriri na 1-2 a ɗakin zazzabi.
Don haɗa allura, cire alamar kariya daga akwati ta allura ba tare da cire ƙofofin waje da na ciki na allura ba. A hankali haɗa da allura, tare da maɗaukakken abincinta, daidai wajan tafki (ta dunƙule ciki ko latsawa, ya danganta da irin allura). Kar a sanya allura a kwana, domin wannan na iya haifar dashi ya fashe ko insulin ya fita daga tsarin kuma zai haifar da allurar da ba ta dace ba. Lokacin ɗauka, kar a danna allura da ƙyar. Kuna buƙatar tabbatar cewa an matsi maɓallin kashi.
Kafin kowane allura, dole ne a gwada lafiya. Don gwajin aminci na farko, kashi ya kamata ya zama raka'a 8 na insulin lokacin amfani da sabon, alƙalin sihiri wanda ba a amfani dashi. Tabbatar cewa alamun sashi yana nuna lambar 8. Idan wannan ba haka lamarin ba, yi amfani da sabon alkalami mai sa maye. Sanya maɓallin kashi gwargwadon damarwa. Koma dawo da jujin juji idan an cire maɓallin kashi.
Don alkalami da aka riga aka yi amfani dashi, saita mai nuna adadin zuwa lambar 2 ta sauya makunnin ƙira. Za'a iya juya miturin a kowane bangare. Cire maɓallin kashi. Bincika idan lambar akan maɓallin ta dace da adadin da aka zaɓa akan sauyawar dosing. Abubuwan haɗari na baƙi suna nuna adadin raka'a.Thickarshen datti na ƙarshe lokacin farin ciki wanda yake bayyane akan maɓallin (kawai ɓangarensa na sama yana iya gani) yana nuna adadin cajin. Don ganin lokacin farin ciki na ƙarshe, zaku iya juya ko karkatar da alkairin maɓallin.
Cire iyakokin bututun ciki da na waje. Riƙe alkairin sirinji tare da allura a sama, yana da sauƙi sauƙaƙe akwati tare da insulin tare da yatsanka don ƙwanƙolin iska ya tashi a cikin hanyar allura. Latsa maɓallin sakin har zuwa kullun don sakin kashi. A wannan yanayin, zaku iya jin maɓallin da zai dakatar bayan an danna maɓallin kashi. Idan insulin ya bayyana a saman allura, na'urar zata yi aiki daidai. Idan insulin bai bayyana ba a saman allura, maimaita umarnin da ke sama. Idan digo na insulin din bai bayyana koda bayan maimaita gwajin lafiya ba, duba na'urar don kumburin iska. Idan akwai, maimaita gwajin aminci har sai sun shuɗe. Idan babu kumburin iska, allurar na iya toshewa, ta yadda ya kamata a musanya shi.
Bayan shigar da allura, danna maɓallin kashi har zuwa gaba. Bar allura a cikin fata na akalla awanni 10. Ya kamata a nade maballin kashi har sai an cire allurar. Bayan cirewa, ba a kwance allura ta juyawa da tafiya ba. Za'a iya amfani da allurar sau ɗaya kawai.
Ana bincika ragowar don ragowar insulin
Sikeli kan tafki na fili yana nuna adadin insulin ɗin da ya rage a alƙalin sirinji. Wannan sikelin ba an yi nufin sanin yawan sinadarin insulin ba. Idan piston na baki yana kusa da alamar 40 a farkon farawar launi, wannan yana nuna cewa ragowar insulin a cikin sirinji mai ƙima shine kusan 40 IU. Stoparshen ƙarshen launi yana nuna cewa alkalami ya ƙunshi kimanin 20 IU na insulin. Tare da ƙarancin insulin a cikin tanki, zaku iya bincika kasancewar ta amfani da maɓallin kashi.
Kada ku yi amfani da alkalami idan ba ku tabbatar da isasshen insulin ɗin don kashi na gaba ba. Misali, idan an saita mai nuna sigina a 30 IU, amma an cire maɓallin kashi ba fiye da 12 IU ba, wannan yana nufin cewa 12 IU na insulin kawai za'a iya allura tare da wannan alƙalin sirinji. A wannan yanayin, ana iya gabatar da ɓace 18 IU ta amfani da sabon sirinji na syringe ko amfani da sabon sirinji don sarrafa cikakken kashi 30 na IU na insulin.

Sakamakon sakamako na miyagun ƙwayoyi Lantus

Hypoglycemia shine mafi rikitarwa na yau da kullun a cikin aikin insulin (musamman idan ana amfani dashi a cikin allurai). Poarfin hypoglycemia mai zurfi na iya haifar da rikicewar jijiyoyin cuta kuma haɗari ne ga rayuwar mai haƙuri. Abubuwan da suka biyo baya wadanda aka lura yayin gwaji na asibiti na amfani da miyagun ƙwayoyi an gabatar dasu akan tsarin kwayoyin don rage yawan bayyanar su (sau da yawa 1/10, sau da yawa 1/100, amma ≤1 / 10, da wuya 1/1000, amma ≤ 1/100, da wuya - 1/10000, amma ≤1 / 1000, wani lokacin ≤1 / 10000) da raguwa cikin mahimmanci.
Daga gefen metabolism: sau da yawa sau da yawa - hypoglycemia. Mai tsananin rashin ƙarfi, musamman maimaitawa, na iya haifar da lalacewar tsarin mai juyayi. Tsawo ko tsawan hypoglycemia na iya zama barazanar rayuwa. A cikin marasa lafiya da yawa, alamun hypoglycemia suna gab da alamun alamun adrenergic counterregulation (kunnawa na tsarin juyayi a cikin amsawar hypoglycemia), ƙari kuma da sauri matakan glucose na jini yana raguwa, mafi bayyanar alamun bayyanar cututtuka.
Daga tsarin rigakafi: da wuya - halayen rashin lafiyan. Wani lokacin halayen rashin lafiyan nau'in kai tsaye zuwa insulin suna haɓaka. Irin waɗannan halayen ga insulin (gami da insulin glargine) ko kuma ga abubuwan da miyagun ƙwayoyi (ke haifar da tasirin fata, angiodema, bronchospasm, hypotension da shock) na iya yin barazanar rayuwar mai haƙuri.
Yin amfani da shirye-shiryen insulin na iya haifar da bayyanar cututtukan rigakafi a kanta.A cikin bincike na asibiti, an bayyana giciye-abubuwa na rigakafi ga insulin na mutum da kuma gulingine insulin. Kasancewar rigakafi zuwa insulin na iya buƙatar daidaita sashi.
Daga hankula: da wuya sosai - dysgeusia.
Daga gefen gabar hangen nesa: da wuya - raunin gani. Canjin da aka ambata a cikin sukari na jini a cikin jini na plasma na jini na iya haifar da rauni na gani na ɗan lokaci sakamakon canji na ɗan lokaci a cikin turgor da kuma juyawar ruwan tabarau na ido. Rashin gani da ido yana da alaƙa da tunani mai lalacewa.
Da wuya, retinopathy. Cigaba da ci gaba a cikin glycemia yana rage haɗarin ci gaban cututtukan cututtukan zuciya. Increasearin haɓaka da haɓakar ƙwaƙwalwar insulin bayan gyaran da bai yi nasara ba na glycemia yana ƙara haɗarin ci gaban cututtukan cututtukan zuciya. A cikin marasa lafiya da cututtukan retinopathy na proliferative, musamman ma waɗanda ba su yi aikin daukar hotococolation ba, yanayin hypoglycemic mai tsanani zai iya haifar da amaurosis.
A bangare na fata da kasusuwa na jiki: sau da yawa - lipohypertrophy, da wuya - lipoatrophy, wanda ke haifar da raguwa cikin ɗaukar insulin na gida. Canji koyaushe a wurin allurar na iya rage zafin waɗannan abubuwan mamaki ko hana su. Wataƙila haɓakar hyperemia na fata a wurin allurar (a cikin 3-4% na marasa lafiya), wanda ya ɓace yayin ƙarin jiyya na 'yan kwanaki zuwa makonni da yawa.
Daga tsarin musculoskeletal: da wuya - myalgia.
Gabaɗaya halayen gida: sau da yawa - halayen a wurin allura (hyperemia, zafi, itching, amya, kumburi ko kumburi). Yawancin halayen gida, a matsayin mai mulki, suna wuce passan kwanaki ko makonni.
A wasu halaye, nadin shirye-shiryen insulin yana haifar da jinkiri a cikin sodium da ruwa a cikin jiki da kuma bayyanar edema na yanki, idan ikon glycemic na baya bai isa ba.

Umarnin na musamman don amfanin Lantus na miyagun ƙwayoyi

Lantus ba shine insulin zaɓi na lura da cutar ketoacidosis mai ciwon sukari ba. A irin waɗannan halayen, ana bada shawarar gudanar da ivullen insulin mai sauƙi.
Kafin farawa da daidaitawar kashi a yanayin rashin isasshen ingantaccen iko na glucose na plasma ko halayyar cututtukan hypoglycemia ko hyperglycemia, ya zama dole a duba yardawar mai haƙuri dangane da tsarin kulawa da maganin da aka gabatar, wurin allura, daidaitaccen dabarar sarrafa magunguna da sauran mahimman abubuwan.
Hypoglycemia. Sakamakon magunguna na Lantus (mafi yawan wadataccen insulin basal), haɓakar haɓakar ƙashin jini ya fi dacewa da sassafe safiya fiye da dare.
Tare da matsanancin taka tsantsan kuma tare da kulawa da kullun na cutar glycemia, ana amfani da miyagun ƙwayoyi a cikin waɗanda ke cikin marasa lafiya waɗanda hypoglycemia ya kasance mai tsananin ciwo, alal misali a cikin marasa lafiya da matsanancin ƙarancin ƙwayar jijiya ko tasoshin ƙwayar cuta (haɗarin mummunar bugun zuciya ko rikicewar cututtukan hanji), kazalika a cikin marasa lafiya tare da proliferative retinopathy, wanda bai ɗaukar hotocoagulation (hadarin haɗarin amaurosis na lokaci).
Yarda da tsarin magani da abinci mai gina jiki, gudanarwar insulin da yakamata da kuma sanin alamomin hypoglycemia suna da mahimmanci don rage haɗarin cutar hypoglycemia.
Abubuwan haɗari don haɓaka hypoglycemia sun haɗa da: canza wurin allura, kara yawan insulin (alal misali, bayan kawar da damuwa), matsanancin motsa jiki ko tsawan aiki, cututtukan haɗuwa, amai, gudawa, abinci tsallake, shan giya, wasu cututtukan endocrine marasa rikitarwa (hypothyroidism, insufficiency) aikin pituitary ko adrenal gland ayyuka), a lokaci guda amfani da wasu kwayoyi.
A wasu yanayi, alamun bayyanar cututtukan ƙwayar cuta na iya canzawa, rasa ƙarfi ko kasancewa gaba ɗaya: wani dogon tarihin ciwon sukari mellitus, cututtukan kwakwalwa, neuropathy na haɗu, haɗaka ta amfani da wasu magunguna, canji daga insulin na asalin dabba zuwa ɗan adam, har ma da tsofaffi marasa lafiya ko ci gaba na hankali na hauhawar jini ko tare da ingantaccen ci gaba a cikin sarrafa glycemic. A wannan yanayin, mummunan hypoglycemia na iya haɓaka (tare da yiwuwar asarar hankali) tun kafin majinyacin ya fahimci gaskiyar hypoglycemia.
Tare da daidaitaccen ko rage matakin glycosylated haemoglobin, yana da buqatar yin la’akari da yiwuwar maimaitawa, latent (musamman da dare) aukuwa na hypoglycemia.
Cutar da alaƙa . A gaban wata cuta ta concomitant, saka idanu sosai game da metabolism na mai haƙuri ya zama dole. A yawancin halaye, an nuna ƙaddarar ketones a cikin fitsari, sau da yawa ya zama dole don daidaita sashin insulin. Bukatar insulin sau da yawa yana ƙaruwa. Marasa lafiya da ke dauke da nau'in na ciwon sukari yakamata su cinye carbohydrates a kai a kai, koda da adadi kaɗan, harma da amai da sauransu Karka taɓa tsallake allurar insulin gabaɗaya.
Ciwon hanta ko aikin koda. Saboda ƙarancin ƙwarewa, inganci da amincin Lantus ga marasa lafiya da nakasa aikin hanta ko tare da matsakaici da / ko raunin ƙwayar cuta ba a fayyace su ba. A cikin marasa lafiya waɗanda ke fama da rauni na aikin ƙirar, da buƙatar insulin na iya raguwa saboda raguwar metabolism metabolism. A cikin tsofaffi marasa lafiya, rage aiki na renal na iya haifar da raguwa mai yawa a cikin bukatun insulin.
A cikin marasa lafiya da raunin rashin ƙarfi na hepatic, ana iya rage buƙatar insulin saboda raguwar gluconeogenesis da raguwa a cikin metabolism metabolism.
Haihuwa da lactation . Babu ƙwarewar asibiti dangane da gwaji na asibiti na amfani da insulin glargine a lokacin daukar ciki. A cikin binciken kwatancen, babu wani takamaiman teratogenic da tayi a yayin daukar ciki, da kuma batun haihuwa da ci gaba a cikin bayan haihuwa.
Sabili da haka, dole ne a kula lokacin da ake rubuta magani. A lokacin daukar ciki, ciki har da na marasa lafiya da ciwon sukari, yana da mahimmanci don sarrafa matakin cutar glycemia. Za'a iya rage buƙatar insulin a cikin farkon farkon lokacin ciki kuma ya karu a cikin watanni na biyu da na uku. Nan da nan bayan haihuwa, buƙatar insulin da sauri yana raguwa (haɗarin haɓakar haɓakawar jini yana ƙaruwa), saboda haka yana da mahimmanci a kula da matakin glucose a cikin jini na jini. Yayin shayarwa, ana buƙatar daidaita sashin insulin da rage cin abinci.
Yara. An tabbatar da inganci da amincin amfani da Lantus a cikin yara don amfanin shi da yamma kawai. Ba'a yi amfani da Lantus a cikin yara 'yan ƙasa da shekaru 6 ba, tunda ba a tabbatar da inganci da amincin miyagun ƙwayoyi a cikin yaran wannan nau'in ba.
Thearfin yin tasiri akan ƙimar amsawa yayin tuki motoci da aiki tare da kayan aiki. Game da rashin cancantar zaɓi na kashi ko maye gurbin miyagun ƙwayoyi, har ma da batun rashin daidaituwa na tsarinsa ko abincin da bai dace ba, canjin yanayi mai yawa a cikin glucose a cikin jini yana yiwuwa, da farko zuwa hypoglycemia, wanda zai iya yin mummunan tasiri game da ikon hawa motoci, musamman a farkon lokacin magani, kazalika da amfani da giya ko kwayoyi lokaci guda kan aiki da tsarin juyayi na tsakiya.

Mu'amala da Magunguna Lantus

Hypoglycemia na iya haɓakawa tare da amfani da magunguna lokaci guda Lantus tare da wakilai na hypoglycemic na bakin, masu hana ACE, rashin biyayya, fibrates, fluoxetine, MAO inhibitors, pentoxifylline,propoxyphene, salicylates da sulfonamides. Ingantaccen maganin Lantus na iya rage shi ta hanyar corticosteroids, danazol, diazoxide, glucagon, isoniazid, estrogens da progesterone, abubuwan asali na phenothiazine, somatropin, sympathomimetics (epinephrine, salbutamol, terbutaline), hormones ta thyroid, antihe-anti-anti-anti-anti-cylinchin, anti-anti-anti-anti-anti-anti-cyheran Blo-adrenoreceptor blockers, clonidine, salhi mai narkewa, pentamidine ko barasa na iya yin ƙarfi ko raunana tasirin insulin. Tare da yin amfani da lokaci-lokaci na ckers-adrenergic receptor blockers, clonidine, guanethidine, reserpine tare da insulin, tasirin su na iya ragewa ko ɓacewa, tare da raunana alamun cututtukan adrenergic counterregulation.
Bai kamata a gauraya Lantus tare da wasu kwayoyi ba. Kada a sanya sirinji don gabatarwar Lantus kada ya ƙunshi adadin magunguna.

Doaukar yawan magunguna Lantus, alamu da magani

Zai iya haifar da rashin ƙarfi da tsawan jini. Za'a iya kawar da cutar sikari ta hanji ta hanyar yawan cin abinci mai narkewa a jiki. A cikin mummunan hypoglycemia (bayyanar neurological, coma), gudanarwar intramuscular ko subcutaneous na glucagon, ana buƙatar gudanar da aiki na glucose. Bayan dakatar da hypoglycemia, ana buƙatar saka idanu akan haƙuri da kuma cin abinci mai narkewa, tun da yanayin hypoglycemic na iya sake komawa na wani lokaci.

Yanayin ajiya na miyagun ƙwayoyi Lantus

A zazzabi of 2-8 ° C. Kada a bada izinin daskarewa. Kada ka sanya vial a cikin injin daskarewa. Lokacin amfani, adana a zazzabi na waje har zuwa 25 ° C. Dole ne a yi amfani da kwalban buɗe don kwanaki 28 lokacin da aka ajiye shi a cikin sanyi, wuri mai duhu a yanayin zafi har zuwa 25 ° C (amma ba a cikin firiji).

Jerin magunguna inda zaka iya siyan Lantus:

Form sashi

1 ml na bayani ya ƙunshi

abu mai aiki - gulingine insulin (raka'a insulin din) 3.6378 MG (raka'a 100)

tsofaffi don mafita a cikin kabad: metacresol, chloride zinc, glycerin (85%), sodium hydroxide, acid hydrochloric acid, ruwa don allura.

magabatanta don maganin a cikin murfin: metacresol, polysorbate 20, zinc chloride, glycerin (85%), sodium hydroxide, acid hydrochloric mai karfi, ruwa don allura.

M mara launi ko kusan ruwa mara launi.

Kayan magunguna

Idan aka kwatanta da insulin mutum na NPH-insulin, yawan tara insulin a cikin batutuwa masu koshin lafiya da marasa lafiya da masu fama da cutar siga bayan subcutaneous management of insulin glargine sun nuna a hankali da kuma daukar lokaci mai tsawo, harma da rashin kololuwa. Saboda haka, abubuwan da aka tara sun kasance daidai da bayanin martaba na wucin gadi na aikin insulin glgine na insulin. Hoto na 1 yana nuna bayanan ayyukan ayyukan insulin glargine da kuma NPH-insulin a kan lokaci. Tare da gabatarwar sau ɗaya a rana, daidaituwa na insulin glargine a cikin jini an samu shi ne kwanaki 2-4 bayan kashi na farko. Tare da gudanarwa na ciki, rabin rayuwar insulin glargine da insulin na mutane sun yi kama.

Bayan allurar subcutaneous na Lantus a cikin marasa lafiya da ciwon sukari mellitus, insulin glargine yana da sauri metabolized a ƙarshen polypeptide beta sarkar don samar da abubuwa masu aiki na metabolites guda biyu M1 (21A-Gly-insulin) da M2 (21A-Gly-des-30B-Thr insulin). A cikin plasma, babban fili kewaya shine metabolite M1. Addamar da metabolite na M1 yana ƙaruwa daidai da maganin da aka tsara na Lantus.

Sakamakon magani na Pharmacokinetic da magunguna sun nuna cewa sakamakon allurar subcutaneous na Lantus an samo asali ne daga kadaici na metabolite M1. Ba a samo insulin glargine da Mite metabolite ba a cikin yawancin marasa lafiya, lokacin da aka samo su, yawan hankalinsu ya kasance mai zaman kansa ga adadin da aka tsara na Lantus.

A cikin gwaji na asibiti, nazarin ƙungiyoyi da aka kafa ta hanyar shekaru da jinsi bai bayyana wani bambanci ba ga inganci da aminci tsakanin marasa lafiya da aka bi da insulin glargine da jimlar yawan binciken.

Pharmacokinetics a cikin yara masu shekaru 2 zuwa 6 tare da nau'in ciwon sukari na 1 an kimanta su a cikin binciken asibiti (duba "Pharmacodynamics"). “Karamin” matakan insulin glargine da manyan plasma metabolites M1 da M2 aka auna a cikin yaran da aka yiwa insulin glargine, kuma an gano cewa samfuran plasma maida hankali ne kwatankwacin samfuran manya, shaidar da ke tallafawa tarin insulin glargine ko metabolites dinsa. tare da tsawaita gudanarwar mulki ba su nan.

Insulin glargine kwatanci ne na insulin ɗan adam, wanda aka ƙera don samun ƙarancin rashin ƙarfi a matsakaicin pH. Ya narke gaba daya a pH na acidic na Lantus® Injection (pH 4). Bayan subcutaneous gwamnatin, da acidic bayani ne neutralized, haifar da samuwar wani microprecipitate, daga abin da insulin glargine ne ci gaba da saki a cikin adadi kaɗan, samar da wani ko, mafi girma-free, tsinkaye taro / bayanin martaba lokaci tare da dogon tsawon aiki.

Haɗawa masu karɓar insulin: a cikin binciken da aka yi a cikin vitro sun nuna cewa kusancin insulin glargine da metabolites M1 da M2 ga masu karɓar insulin na mutum ɗaya ne da na insulin na mutum.

Abin da ke karɓa na mai karɓa na IGF-1: kusancin insulin glargine ga mai karɓa na IGF-1 shine kusan 5-8 sau mafi girman insulin na mutum (amma kusan sau 70-80 ƙasa da IGF-1), yayin da M1 metabolites da M2 suna ɗaure wa mai karɓa na IGF-1 tare da ɗan ɗanɗano ɗan inuwa idan aka kwatanta da insulin ɗan adam.

Jimlar warkewar insulin (insulin glargine da metabolites), an ƙaddara a cikin marasa lafiya da nau'in 1 sukari mellitus, an lura da ƙarancin da za a buƙaci rabin matsakaicin karɓa daga kamawar mai karɓa na IGF-1 da kuma kunnawa na mitogenic proliferative wayway da aka samu ta hanyar mai karɓa na IGF-1 . Haɗarin ilimin ɗan adam na IGF-1 yana iya kunna hanyar haɓakawa na mitogenic, duk da haka, yawan kwantar da hankali da aka ƙaddara a lokacin aikin insulin, ciki har da maganin Lantus, yana da ƙasa ƙasa da yawaitar abubuwan da ake buƙata don kunna IGF-1 hanya.

Babban aikin insulin, gami da insulin glargine, shine daidaita tsarin metabolism. Insulin da analogues dinsu suna rage matakan glucose na jini ta hanyar kara yawan glucose a cikin kasusuwa na musamman, musamman kasusuwa da tsotsar nama, da kuma ta hanyar samar da glucose a cikin hanta. Insulin yana hana lipolysis a cikin adipocytes, yana hana proteolysis kuma yana haɓaka aikin furotin. Nazarin asibiti da magunguna sun nuna cewa gudanarwar insulin glargine ta insravenine da insulin na mutum sun yi daidai lokacin da aka gudanar dasu a allurai iri daya. Kamar yadda yake tare da duk insulins, aiki na jiki da sauran abubuwan zasu iya tasiri tsawon lokacin aikin insulin glargine.

A cikin binciken amfani da euglycemic clamp a cikin masu sa kai masu lafiya da marasa lafiya da nau'in 1 sukari mellitus, aikin subcutaneously allurar insulin glargine ya kasance mafi sauƙi fiye da insulin na NPH na mutum, sakamakon insulin glargine ya zama mai sassauƙa kuma mafi ƙarancin lokaci, tsawonsa ya fi tsayi.

Lokaci (awanni) ya wuce bayan allurar subcutaneous

Endarshen lokacin lura

* an ayyana shi azaman adadin glucose da aka saka don kula da matakin glucose na jini koda yaushe (matsakaicin awa).

Longerarin aikin da ke cikin ƙananan ƙwayar insulin glargine wanda aka allurar yana da alaƙar kai tsaye ga ɗaukar jinkirinsa, wanda ke ba da damar amfani da miyagun ƙwayoyi sau ɗaya a rana.A cikin mutane daban-daban kuma a cikin mutum ɗaya, tsawon lokacin aikin insulin da analogues, kamar su insulin glargine, na iya bambanta sosai.

A cikin bincike na asibiti, alamun hypoglycemia ko alamun maganin hana haifuwa a cikin masu ba da agaji da lafiya kuma a cikin marassa lafiya da ke da nau'in ciwon sukari na 1 iri ɗaya ne bayan gudanarwar cikin ciki na insulin glargine da insulin na mutum.

Insulin lantus da makamantanta analogues. Insulin Lantus da kwatancensa: muna ƙididdigar adadin safe da maraice daidai

Mellitus-insulin-da ke fama da cutar sikila (T1DM) cuta ce mai gado, galibi tana yin muhawara a samartaka. A cikin wannan nau'in ciwon sukari, ƙwayoyin beta na pancreatic ba su haifar da isasshen ko ba su haifar da ƙwayar insulin (Insulinum), wanda ke da alhakin amfani da sukari a cikin jini ta hanyar ƙwayoyin tsoka mai narkewa.

Don taimakawa jiki shan glucose kuma kada ya mutu daga maye sukari, ana tilasta marasa lafiya suyi allurar roba ta insulin roba mai kama da mutum, gami da kwayar Insulin Lantus da maganin ta.

Bayanai da bidiyo a cikin wannan labarin za a keɓe su ga wannan batun. Af, yana iya zama da amfani ba kawai ga masu ciwon sikila-da ke fama da cutar T1DM ba, har ma ga marasa lafiya da ke fama da rashin insulin, da kuma mata masu ciki da ke fama da cutar sankara.

“Abun wucin gadi” allurar insulin na tsawon lokaci ana iya wajabta shi, alal misali, don ramawa game da tsananin cutar, yayin tsananin lokacin SARS ko wasu cututtukan. Za su taimaka wajen hana samuwar ci gaba da cututtukan ciwon sukari a cikin tsarin zuciya, kodan da idanu.

Don maganin maye gurbin hormone don ciwon sukari, an tsara nau'ikan shirye-shiryen homon 5 na insulin kuma ana samarwa:

• dabaru () - ana amfani da su ko kafin abinci, ko kuma a gabatar da kai da sauri don magance babban taro a cikin jini,
• NPH (NPH) da basal (matsakaici da dogon aiki) - Wajibi ne don sarrafa sukari na jini a lokaci-lokaci yayin da dansandan karas suka daina aikinsu,
• tushen bolus (haɗuwa da siffofin bolus tare da NPH ko basal, har ma da haɗuwa da NPH da basal) sun dace sosai, amma amfani da su cikin yawancin yana haifar da rikice-rikice da yawa da kuma buƙatar sauƙaƙawa tashin hankali mai ɗorewa sakamakon hakan.

Lantus wani nau'in basalin aiki ne wanda ya dade yana aiki. A hakikanin gaskiya, Lantus shine sunan farkon analog na insulinum na mutum tare da aiki mafi ƙarancin sa'o'i 24, wanda kamfanin samar da magunguna na duniya Sanofi-Aventis ya ƙera, tare da hedikwata a Paris.

Lantus mai aiki shine kwayar halittar insulin ta mutum da aka inganta shi. Lantus ya ƙunshi a cikin 1 ml 100 IU (3.6378 MG) wani abu mai kama da ƙwayar mutum, wanda a cikin abin da ake maye gurbin asparagine daga amino acid a-sarkar ta hanyar glycine, kuma ragowar 2 arginine suna “glued” har zuwa ƙarshen sarkar.

Godiya ga wannan tsari, wannan kwayar halitta da aka kirkirar tana da wadannan halaye:

• miyagun ƙwayoyi sun fi dacewa da ma'anar kwayar halitta ta 'insulinum' a cikin jikin mutum,
• allurar ana yin ta sau 1-2 ne kawai a rana, kuma baya buƙatar katsewar bacci don yin ƙarin allura, yana samar da iko da matakan glucose da dare,
• kada ku gauraya maganin kafin allurar,
• ciwon glycemia yana da sauƙin biya ta hanyar rama ga masu ciwon sukari,
• hadarin kamuwa da cuta ya zama kadan,
• sabanin sauran kwayoyi, babu wani banbanci inda za'a saka farashi - ƙarƙashin fatar kan ciki, cinya ko kafada,
• aikin ya yi laushi, matukar mahimmin bayanin martaba mai tsada na ci gaba da kasancewa cikin kwayar insulin,
• inganta metabolism-lipid metabolism gaba ɗaya.

HankaliMasu fama da cutar siga tare da daidaituwa ko kuma raguwar maida hankali na glycated haemoglobin na iya zuwa lokaci-lokaci fuskantar cututtukan cututtukan cututtukan zuciya na dare.

Umarnin insulin Lantus don amfani a fili yana nuna cewa masu ciwon sukari suna buƙatar tunawa - matakin motsa jiki yana rinjayar yanayin aikin glargine. Sabili da haka, kafin da bayan horo (aikin motsa jiki ko wani mahimmancin motsa jiki, alal misali, yin aiki a gonar), ma'aunin glucose na jini ya zama dole, kuma idan ya cancanta, gyara tare da insulin-gajere.

A bayanin kula. Kamar kowane abu na magani na hormonal, Lantus insulin glargine ko analogues dole ne a adana shi a kan ƙananan shiryayye na firiji, a zazzabi mai zafi na 2 zuwa 8 Celsius. Bayan bude maganin, rayuwar ajiyar sa kamar kwanaki 40 kenan.

Analogs Lantus

Daidaita ma'anar Lantus shine alkalami na Tujeo SoloStar. Menene bambance-bambance tsakanin su? Abun da ke aiki na Tujeo daidai yake da na Lantus - glargine, amma a cikin 1 ml na maganin Tujeo ya ƙunshi sau 3 fiye da na Lantus.

Wannan yana ba ku damar fadada aikin daga awanni 24 zuwa 35, sannan kuma ku rage yawan haɗarin kamuwa da cututtukan jini. Abin takaici, akwai ra'ayoyi da yawa marasa kyau game da Tujeo akan Intanet, amma wataƙila su ƙididdigar ba daidai ba ne ta hanyar masu ciwon sukari na allurar canji daga wani magani mai tsawo zuwa wani.

A halin yanzu, analogues na Lantus SoloStar (insulin glargine) sune:

1. Levemir da Levemir Flexpen daga Novo Nordisk. Tushen su shine insulin ɗin aiki mai aiki. Ba kamar sauran shirye-shiryen insulin na dogon lokaci ba, ana iya mai da shi, yana mai da shi mafi kyawun magungunan basal ga yara masu fama da ciwon sukari. Kuna iya ƙarin koyo game da fa'idodin wannan magani na hormonal daga bidiyo.

1. Tresiba, Tresiba FlekTach da Tresiba Penfill dangane da insulin degludec mai aiki. An ba da izinin amfani da yara daga shekara 12. Yana da mafi tsawan matakin aiki a cikin awanni 42. Yin amfani da wannan nau'in insulin hormone yana taimakawa wajen daukar nauyin wannan mummunan abu ga masu ciwon sukari kamar "cututtukan alfijir na safe".

Ga waɗanda suke da ikon kuɗi, masana ilimin kimiyyar halitta na ƙasashen waje suna ba da shawarar sauyawa daga dogon Lantus zuwa tsawan Levemir ko, musamman, zuwa mafi tsawo na waɗanda suke wanzu, insulin Tresiba. Loguearshen insulin na anaulin Lantus - degludec, ana ɗauka mafi kyawun insulinum mafi mahimmanci. Koyaya, mafi kyau, alas, lokaci guda shine mafi tsada.

Mene ne Lantus SoloStar?

Lantus SoloStar baya amfani da analogues na glargin. Bambanci kawai tsakanin "talakawa Lantus" da SoloStar shine nau'i na "marufi" na glargine mai aiki. A zahiri, SoloStar shine sunan da aka mallaka don rubutun alkalami na musamman da iyalen allura guda-lokaci.

Siffofin amfani da insulin dogon lokacin daukar ciki

Mata masu juna biyu waɗanda suke buƙatar allurar insulin ya kamata su tuna, kodayake wannan kayan ba shi da ikon ƙetare mahaifa, yana da mahimmanci cewa illar da miyagun ƙwayoyi ta yi game da tayin ne ta hanyar ilimin likita, kuma an tabbatar da amincinsa ta gwajin sarrafawa.

Yau, abubuwanda aka yanke da shawarwari masu zuwa:

1. Ba a yi gwajin gwaji na Tujeo da Tresib tare da halartar mata masu juna biyu ba, saboda haka ba a ba da shawarar yin amfani da su ba tukuna.
2. Amintacciyar lafiyar tayin Lantus ba a tabbatar da cikakke ba, amma babban kwarewa da aka samu a duk faɗin duniya, tare da kyakkyawan sakamako ba tare da mummunan sakamako ba ga lafiyar jarirai, ya ba da damar, a cikin 2017, bisa izini bisa izinin amfani da shi a Rasha.
3. Mafi yawan binciken daga likitoci Levemir.An ba da shawarar yin amfani da shi duka lokacin daukar ciki da kuma ga matan da ke da ciwon sukari don canzawa zuwa gareta a matakin matakin daukar ciki.

A bayanin kula. Jerin gajeren kwayoyin insulin, tare da ingantaccen aminci don haɓakar tayin, sun haɗa da Humalog da Novorapid, kuma Apidra sun faɗi cikin nau'in da aka haramta.

Yaya ake lissafin yawan insulin basal?

Kafin yin lissafin kashi don maganin insulin tare da ɗayan dogon insulin analogues, yakamata ku ci gaba:

• Tabbatacce kuma ba tare da izini ba ci gaba da rage cin abincin carb. Ba tare da yin riko da tsayayye ba, abu ne mai wuya mutum ya sami tsayayyen raguwar yawan ƙwayar glucose na jini a matakin 3.9-5.5 mmol / L, sabili da haka don hana ci gaban cututtukan ciwon sukari.

• Fara aiwatar da cikakken bayanin inda zaka rubuta:
  1. alamomin sukari na jini, mafi ƙaranci - da safe a kan komai a ciki, bayan sa'o'i 3 bayan karin kumallo, da abincin rana da awa 3 bayansa, da gabanin cin abincin dare da kuma kafin lokacin cin abinci,
  2. cin abinci, abinci, da abin sha,
  3. shan ƙarin magunguna
  4. menene kuma lokacin da insulin hormone yake yin allurar, menene amsa zuwa gare shi, fassarar allura, kuma yana fitowa,
  5. menene kuma yadda aiki na jiki yake shafar matakin glucose a cikin jini (ma'aunin ma'aunin glucose ya zama dole kafin da bayan sa),
  6. amsawar jiki - kwanciyar hankali da matakin sukari: bayan damuwa, a yanayi, bayan shan giya da kofi.
• Yi wa kanka abinci da wuri - ci da aƙalla sama da awanni 5 kafin fara kwanciya.
• Zaɓi takamaiman lokacin, zai fi dacewa 1 sa'a kafin lokacin bacci, don yin awo na yau da kullun. Karka zama mai saurin rubuta wannan adadi a cikin rubutacce.

Oƙarin sanya bayanan kula daki-daki. Kada ku ɗanɗana kuɗi, kuma a cikin kwanaki 4-7, ku auna matakin glucose a kowane lokaci.

Haske. Ana iya yin allurar bacci ta dogon lokaci kafin lokacin bacci ko da sanyin safiya. Magarin maraice yana taimaka wajan kawar da cututtukan alfijir na asuba ta hanyar sarrafa glucose na jini da daddare da safe. Idan an yi rikodin cewa abincin dare da wuri zai ba ku damar adon glucose a cikin adadin 4.0-5.5 mmol / l, to, ba kwa buƙatar allurar basal kafin abinci kafin lokacin kwanciya.

Dabarar da za ayi amfani da ita don yin lissafin adadin insulin tsawon dare

Don farawa, ta amfani da shigarwar bayanan, ta hanyar lissafi, ƙayyade mafi ƙarancin bambanci, don kwanakin 3-4 na ƙarshe, a cikin ƙimar glucose da aka auna da maraice da kuma a kan komai a ciki da safe (MRHU). Sannan ku ƙididdige ƙididdigar bisa ga tsarin da mashahurin endocrinologist na Amurka Richard Bernstein ya bayar.

Undulla da sakamakon da lambar zuwa 0.5. Kar ku damu idan adadin farawa da aka karɓa yana da ƙarami - raka'a 1 ko 0.5. Matsa shi, kuma kar a manta don sarrafa sukari tare da glucometer da safe. Idan bayan kwanaki 3 na irin wannan ilimin ba ku cimma sakamakon da ake so na 4.0-5.5 mmol / l ba, to sai ku ƙara yawan farawa ta hanyar 0.5 raka'a, kuma ku huɗa zuwa wani 3 na yamma. Ba a sake yin aiki ba? Anotheraga wani raka'a 0.5.

Yana da mahimmanci. Da fari dai, darajar glucose mai yawa ba ta da nasaba da kashi "dare" na insulin basal. Abu na biyu, kar a ruga cikin zabin mafi kyau na dare; tabbata cewa kula da “matakin” na kwanaki 3.

Me zai faru idan ka rasa allura?

Za ku sami jini mai yawa saboda rashin insulin a jiki. Preari daidai, saboda rashin daidaituwa na insulin tare da buƙatar jikin mutum game da shi. Levelsara yawan matakan glucose zai taimaka ga ci gaba.

A cikin mawuyacin hali, ana iya lura da rikice-rikice: ketoacidosis mai ciwon sukari ko ƙwaƙwalwar hyperglycemic. Alamomin su suna da illa garesu. Za su iya zama m.

Dabarar da za ayi amfani da ita don yin lissafin yawan sinadarin basal da safe

Umarnin Dr. R. Bernstein kamar haka:

• A kwana a tashi a kan shayi da ruwa, a rubuce a alamomin a cikin sa'oin da aka nuna akan tebur.

• Daga mafi ƙarancin darajar sukari, a wannan yanayin - 5.9, cire lamba 5, wanda shine ƙimar matsakaicin darajar jinin sukari na al'ada.Don haka, RSNNS (bambanci tsakanin mafi ƙanƙancin sukari da na al'ada).
• Bayan haka, aiwatar da lissafin gwargwadon tsari, tuna cewa ya kamata a rubuta nauyi a cikin kilo, amma tare da daidaiton lambar guda ɗaya bayan ma'anar adadin.

• Don tabbatar da yiwuwa ko don daidaita sigar, bi wannan algorithm:
  1. shigar da safe
  2. tsallake karin kumallo, abincin rana da kayan ciye-ciye (zaku iya shan ruwa da shayi da ba a ɗauka ba),
  3. yayin rana, kafin abincin dare da wuri, yi matakan 4-5 tare da glucometer, kuma bisa waɗannan ma'aunin suna yanke shawara ko za a canza kashi kuma idan haka ne, ta wacce hanya, rage ko ƙara, wannan ya kamata a yi.

Hankali! Bayan inje na kowane tsayayyen tsayayyen daka, ba kwa buƙatar cin abinci.

A ƙarshe, muna son bayar da wasu nasihu daga yin amfani da tsararrun masana kimiyya:

• kada ku kashe babban sukari bayan abinci tare da tsawan tsawon lokaci, yi amfani da gajeru ko na gajeren lokaci,
• kawai Treshiba ya dace don allura guda ɗaya kowace rana, amma wannan gaskiyar takamaɗa ɗaya ce, kuma tana buƙatar tabbataccen aiki,
• Zai fi kyau a tsaurara Lantus, Levemir da Tujeo da safe da maraice, a lissafin abubuwan gwargwadon tsarin da ke sama,
• lokacin sauya sheka daga wannan insulin zuwa wani, kara yawan farawa daga 30% na ƙididdigar da aka ƙididdige, kuma bayan kwana 10, bincika daidai - idan ya cancanta, ƙara ko rage.

Kawai ingantaccen magani don maganin ciwon sukari na 1 da ciwon sukari na 2 shine haɗuwa da ƙananan kayan abinci da keɓaɓɓe da zaɓaɓɓun takaddun magunguna masu mahimmanci, duka biyu masu tsawo da gajere ko shirye-shiryen insulin matsananci. Da kyau, don daidaita nauyin jiki, shawo kan ko hana ci gaban insulin juriya a cikin tsokoki, haka kuma hana rikicewar cututtukan zuciya na zuciya, ba tare da maganin motsa jiki ba - hadadden ƙarfin motsa jiki da horo na zuciya - ba za ku iya yi ba.

Zai yuwu mu rayu cikakke tare da nau'in ciwon sukari na 1 da kuma warkewa daga cututtukan type 2, amma wannan yana buƙatar ƙarfe da horo. A cikin kanta, kawai ciwon sukari na mata masu juna biyu zai wuce, amma ya zama sanadin damuwa game da ci gaba, a kan lokaci, na T2DM.

Me yasa yake da mahimmanci ga masu ciwon sukari su bi ba kawai abincin ba, amma akwai ƙananan carb, da kuma ga uwaye mata waɗanda ke da ciwon sukari suyi zama a kai yayin shayarwa, wannan bidiyon yayi bayani.

Insulin Lantus magani ne wanda ke haifar da ragewar sukari a jiki. Abubuwan da ke aiki shine glargine insulin. Wannan kwatancen insulin ne na ɗan adam, wanda ba shi da narkewa a cikin yanayin tsaka tsaki. A cikin kantin magunguna zaka iya ganin siffofin guda 3 na kwantar da magungunan: OptiSet alkalami, OptiClick da Lantus SoloStar. Mene ne sifofin amfani da miyagun ƙwayoyi?

Insulin Lantus yana da sakamako mai ɗorewa, yana inganta haɓakar glucose kuma yana daidaita metabolism. Lokacin shan magani, ana samun hanzarin rage sukari ta hanyar tsoka da ƙashin mai. Hakanan, wakili na hormonal yana kunna samar da furotin. A lokaci guda, ana hana garkuwar kariya da lipolysis a cikin adipocytes.

Contraindications

Contraindicated idan akwai rashin haƙuri a kan aiki abu ko kayan taimako na taimako. Ga matasa, ana yin maganin ne kawai lokacin da suke shekara 16.

Ya kamata a kula da kulawa ta musamman lokacin da ake haifar da ɓarnawar ƙwayar cuta, da keɓanta jijiyoyin jijiyoyin jini da jijiyoyin ƙwayar cuta. Hakanan ana buƙatar lura da lafiyar marasa lafiya tare da alamun ɓoye na hypoglycemia. Cutar na iya mamaye ta ta hanyar hankali, ta ciwon kai, wani tsawan lokaci na ciwon suga.

Dangane da tsayayyen alamu, an wajabta shi don marasa lafiya tsofaffi. Wannan ya shafi mutanen da suka canza daga insulin na asalin dabba zuwa ɗan adam.

Zan iya yin allurar dare Lantus kuma a lokaci guda ana ɗaukar insulin insulin kafin cin abincin dare?

Bisa hukuma - zaka iya.Koyaya, idan kuna da matsala game da sukari na jini da safe a kan komai a ciki, yana da kyau a allurar da Lantus da daddare kamar yadda zai yiwu kafin lokacin kwanciya. Saurin insulin abinci kafin abincin dare, kuna buƙatar shigar da hoursan awanni a baya.

Yana da mahimmanci ka fahimci dalilin kowane inje ɗin da aka lissafa a cikin tambayar. Hakanan kuna buƙatar samun damar zaɓin sashi na shirye-shiryen insulin cikin sauri da tsawaita aiki. Karanta labarin "" don cikakken bayani game da takaice da shirye-shiryen ultrashort.

Lantus na ciwon sukari na 2

Lantus na iya zama maganin da insulin jiyya don kamuwa da cutar siga ta 2 ya fara da. Da farko, sun yanke shawara akan allurar wannan insulin da daddare, sannan da safe. Idan sukari ya ci gaba da girma bayan cin abinci, an ƙara wani ɗan gajeren magani ko kuma ultrashort magani a cikin tsarin kulawar insulin - Actrapid, Humalog, NovoRapid ko Apidra.

Dr. Bernstein ya ba da shawarar karya kashi na yau da kullun zuwa allura biyu - yamma da safiya. Duk da cewa ba a rage yawan allurar rigakafin ba, canzawa zuwa insulin na Tresib har yanzu yana da amfani. Saboda matakan sukari na jini zai inganta. Za su kasance da kwanciyar hankali.

Wanne insulin ne yafi: Lantus ko Tujeo? Mene ne bambanci tsakanin su biyun?

Ya ƙunshi abu mai aiki kamar Lantus - insulin glargine. Koyaya, tattara insulin a cikin maganin Tujeo shine sau 3 mafi girma - 300 IU / ml. Bisa manufa, zaka iya ajiye kadan idan ka je Tujeo. Koyaya, yana da kyau a'a. Nazarin masu ciwon sukari game da insulin na Tujeo yawancin su marasa kyau ne. A cikin wasu marasa lafiya, bayan juyawa daga Lantus zuwa Tujeo, saukar da sukari na jini, a cikin wasu, saboda wasu dalilai, kwatsam insulin kwatsam ya daina aiki. Saboda yawan maida hankali, yakan fashe da kuka yana ɗaukar allura na alkairin alkairin. Tujeo amicably scolded ba kawai a cikin gida, har ma a cikin Turanci-tushen ciwon sukari forums. Don haka, in ya yiwu, zai fi kyau a ci gaba da satar Lantus ba tare da canza shi ba. Zai fi kyau canzawa don dalilan da aka bayyana a sama.

Wanne insulin ne yafi: Lantus ko Levemir?

Kafin zuwan insulin, Dr. Bernstein yayi amfani da shekaru da yawa, ba Lantus ba. A cikin shekarun 1990s, labarai da yawa sun bayyana, suna cewa Lantus yana kara haɗarin wasu nau'in cutar kansa. ya ɗauki maganganu masu mahimmanci, ya dakatar da allurar insulin ga kansa kuma yana tsara shi ga marasa lafiya. Kamfanin masana'antar ya fara nuna damuwa - kuma a cikin 2000s akwai kasidu da dama suna da'awar cewa Lantus ɗin yana da hadari. Mafi m, ko da insulin glargine yana ƙara haɗarin wasu nau'in ciwon daji, to, dan kadan. Wannan bai kamata ya zama dalilin tafiya Levemire ba.

Idan ka shiga Lantus da Levemir a allurai iri daya, to aikin allurar Levemir zai kare da sauri kadan. An ba da shawarar bisa hukuma don yin allurar Lantus sau ɗaya a rana, da Levemir - sau 1 ko sau 2 a rana. Koyaya, a aikace, duka magunguna suna buƙatar yin allura sau 2 a rana, safe da maraice. Daya allura a rana bai isa ba. Kammalawa: idan Lantus ko Levemir suka dace da ku sosai, ci gaba da amfani da shi. Canjin zuwa Levemir ya kamata ne kawai idan ya zama dole. Misali, idan daya daga cikin nau'ikan insulin yana haifar da wata alerji ko ba a daina bayarwa kyauta. Koyaya, wannan wani lamari ne. Yana yin aiki mafi kyau. Zai dace a sauya zuwa idan babban farashin bai dakatar da shi ba.

Marasa lafiya ya kamata su sanar da likita game da halin da ake ciki na yanzu ko kuma shirin yin ciki.

Babu wani gwaji na asibiti da aka ware akan amfani da insulin glargine a cikin mata masu juna biyu.

Yawancin kallo

Bugu da kari, don tantance amincin insulin glargine da kuma amfani da insulin-isophan a cikin mata masu juna biyu da suka kamu da cutar siga ta haihuwa, wadanda aka yi amfani da su, wadanda suka hada da matan da suka yi amfani da insulin glargine yayin haihuwa (n = 331) da insulin isophane (n = 371).

Wannan nazarin-meta bai bayyana bambance-bambance masu mahimmanci ba game da aminci dangane da lafiyar masu juna biyu ko lafiyar jariri lokacin amfani da glargine insulin-inphan yayin daukar ciki.

Ga marasa lafiya da ke cikin yanayin cutar sankarar tsoka ko kuma gestational diabetes, yana da muhimmanci a kula da isasshen tsari na tafiyar matakai na rayuwa a lokacin daukar ciki don hana faruwar sakamako wanda ba a ke so ba wanda ke da alaƙa da cutar hauka.

Ana iya amfani da magani Lantusant SoloStarS a lokacin daukar ciki saboda dalilai na asibiti.

Bukatar insulin na iya raguwa a farkon farkon ciki kuma, gabaɗaya, haɓaka yayin watanni na biyu da na uku.

Nan da nan bayan haihuwa, buƙatar insulin ya ragu da sauri (haɗarin hauhawar jini yana ƙaruwa). A ƙarƙashin waɗannan yanayin, saka idanu cikin hankali akan tattarawar glucose a cikin jini yana da mahimmanci.

Marasa lafiya a lokacin shayarwa na iya buƙatar daidaita tsarin sashi na insulin da abinci.

A cikin nazarin dabbobi, ba a sami bayanai kai tsaye ko kan kai tsaye ba game da tayi ko fetotoxic na insulin glargine.

Zuwa yau, babu ƙididdiga masu mahimmanci game da amfani da miyagun ƙwayoyi yayin daukar ciki. Akwai shaidar amfani da Lantus a cikin mata masu ciki 100 masu ciwon sukari. Hanya da sakamako na ciki a cikin waɗannan marasa lafiya bai bambanta da waɗanda ke cikin mata masu juna biyu da masu ciwon sukari waɗanda suka sami sauran shirye-shiryen insulin.

Yakamata ayi alƙawarin Lantus a cikin mata masu juna biyu da hankali. Ga marasa lafiya da ke da cutar ƙwararrun ƙwayar cutar sankara a cikin mahaifa, yana da muhimmanci a kula da kyakkyawan tsari na tafiyar matakai na rayuwa a lokacin daukar ciki.

Bukatar insulin na iya raguwa a cikin farkon farkon ciki kuma ya karu yayin watanni na biyu da na uku. Nan da nan bayan haihuwa, buƙatar insulin ya ragu da sauri (haɗarin hauhawar jini yana ƙaruwa).

A ƙarƙashin waɗannan yanayin, saka idanu a hankali game da glucose jini yana da mahimmanci.

A cikin mata masu shayarwa, ana buƙatar buƙatar sashin insulin da kuma daidaita yanayin abinci.

Ba a tabbatar da mummunan tasirin miyagun ƙwayoyi a jikin mata masu juna biyu da tayi ba ta hanyar binciken asibiti. Koyaya, mata a lokacin haihuwar yaro dole ne su sha maganin sosai tare da yin taka tsantsan, lura da sakinin da likitan masu halartar ya rubuta.

Yayinda suke shan maganin, mata masu juna biyu suna buƙatar yin gwajin jini a kai a kai don lura da matakin sukari a cikin jiki. Watanni 3 na farko na ciki, ana iya rage bukatar jikin insulin, amma a sati na 2 da na 3 zai iya karuwa. Bayan haihuwar jariri, buƙatar magani ta sake raguwa, wanda ke da alaƙa da canje-canje a cikin yanayin hormonal.

Inganta insulin - Siffofin Jiyya na Ciwon sukari

Tare da cutar, ciwon sukari yana buƙatar maganin kwantar da hankali na insulin. Ana amfani da insulin gajere da dogon insulin don magance cutar. Ingancin rayuwar mai ciwon sukari ya dogara ne da yarda da duk magunguna na likita.

Ana buƙatar ingantaccen insulin da ake buƙata lokacin azumi na azumi jini matakan jini suna buƙatar daidaita. Abubuwan da aka saba yi na yau da kullun sune Levemir da Lantus, waɗanda ya kamata a gudanar da haƙuri sau ɗaya a cikin kowane sa'o'i 12 ko 24.

Dogon insulin yana da dukiya mai ban mamaki, yana da ikon yin kwaikwayon ƙwayar halittar jiki wanda ƙwaƙwalwar ƙwayar hanta ke samar da ita.A lokaci guda, yana da laushi a kan irin waɗannan ƙwayoyin, yana ƙarfafa farfadowarsu, wanda a nan gaba yana ba da damar ƙin canza magungunan insulin.

Ya kamata a bai wa marasa lafiya da ke da ƙwayar sukari haɓaka a cikin rana, amma ya kamata a tabbatar cewa mai haƙuri ya cinye abincin ba aƙalla sa'o'i 5 kafin lokacin kwanciya ba. Hakanan, an wajabta insulin tsawon lokaci don alamar "sanyin asuba", a yanayin sa'ilin da kwayoyin hanta suka fara da daddare kafin mai haƙuri ya farka, ya kawar da insulin.

Idan gajere insulin ya buƙaci allura yayin rana don rage matakin glucose da aka kawo tare da abinci, to insulin tsawon lokaci yana ba da tabbacin yanayin insulin, yana matsayin kyakkyawan rigakafin ketoacidosis, kuma yana taimakawa wajen dawo da ƙwayoyin beta na ciki.

Abubuwan da ake buƙata na karin insulin ya cancanci kulawa a cikin abin da suka taimaka wajen daidaita yanayin mai haƙuri da kuma tabbatar da cewa ciwon sukari na nau'in na biyu ba ya shiga cikin nau'in cutar ta farko ba.

Cikakken lissafin adadin insulin tsawon dare

Don kula da salon rayuwa na yau da kullun, mai haƙuri yana buƙatar koyon yadda za a ƙididdige adadin Lantus, Protafan ko Levemir da dare, don a kiyaye matakan glucose mai azumi a 4.6 ± 0.6 mmol / l.

Don yin wannan, a cikin mako ya kamata ku auna matakin sukari da dare da safe a kan komai a ciki. Sannan yakamata ku kirga darajar sukari da asuba a safiyar asuba da daddare kuma kuyi lissafin karuwa, wannan zai bawa mai nuni da karancin sashi.

Misali, idan mafi karancin sukari ya karu shine 4.0 mmol / l, to 1 rukunin insulin na tsawon lokaci na iya rage wannan alamar ta 2.2 mmol / l a cikin mutum mai nauyin 64. Idan nauyinku shine kilogiram 80, to muna amfani da wannan tsari: 2.2 mmol / L * 64 kg / 80 kg = 1.76 mmol / L

Matsakaicin insulin ga mutum wanda yakai kilogram 80 yakamata ya zama raka'a 1.13, wannan adadin yana zagaye zuwa kusa da kwata kuma muna samun 1.25E.

Ya kamata a lura da cewa Lantus ba zai iya gurɓataccen ba, saboda haka yana buƙatar a allura tare da 1ED ko 1,5ED, amma Levemir za'a iya dil har a allura tare da ƙimar da ake buƙata. A cikin kwanaki masu zuwa, kuna buƙatar saka idanu akan yadda sukari mai azumi zai kasance da haɓaka ko rage sashi.

An zaba shi daidai kuma daidai idan, a cikin mako guda, sukari mai azumi ba ya wuce 0.6 mmol / l, idan ƙimar ya yi girma, to gwada gwada sashi zuwa kashi 0.25 a kowace kwana uku.

Yaushe zaka yi amfani da magani

Ana amfani da magani don ciwon sukari, wanda ke buƙatar magani tare da insulin. Mafi sau da yawa shine nau'in ciwon sukari na 1. Ana iya ba da maganin ta hormone ga duk marasa lafiya da suka haɗu shekaru shida.

Insulin yin aiki da tsayi yana da mahimmanci don kula da yawan kwantar da hankali a cikin jinin mai haƙuri. Mutumin da ke da lafiya a cikin jini koyaushe yana da wani adadin wannan hormone, irin wannan abun cikin jini ana kiran shi matakin basal.

A cikin marasa lafiya da ciwon sukari mellitus idan akwai damuwa na daskararwa, akwai buƙatar insulin, wanda dole ne a gudanar dashi akai-akai.

Wani zabin don sakin hormone a cikin jini ana kiran shi bolus. Yana da alaƙa da cin abinci - a cikin martani don haɓakar sukari na jini, an fitar da wani adadin insulin don saurin daidaita ƙwayar cuta.

A cikin ciwon sukari mellitus, ana amfani da insulins na gajeren lokaci don wannan. A wannan halin, mai haƙuri dole ne ya yi wa kansa allura ta kowane suttini bayan cin abinci, yana ɗauke da adadin abubuwan da ake buƙata na kwayoyin.

A cikin kantin magunguna, ana sayar da adadin manyan magunguna daban-daban don maganin ciwon sukari. Idan mai haƙuri yana buƙatar yin amfani da ƙwayar tsohuwar mataki, to, menene mafi kyawun amfani - Lantus ko Levemir? A cikin hanyoyi da yawa, waɗannan magungunan suna kama da juna - duka biyun asali ne, sune mafi tsinkaye da kwanciyar hankali a amfani.

Zamu gano yadda wadannan kwayoyin suke bambanta.An yi imani da cewa Levemir yana da tsawon rayuwa ta shiryayye fiye da Lantus Solostar - har zuwa makonni 6 a kan wata daya. Sabili da haka, ana ɗaukar Levemir mafi dacewa a cikin lokuta inda kuke buƙatar shigar da ƙananan ƙwayoyi na ƙwayar cuta, alal misali, bin ƙananan abincin carb.

Masana sun ce Lantus Solostar na iya kara hadarin kamuwa da cutar kansa, amma babu wani ingantaccen bayanai game da wannan tukuna.

Glargin da sauran kwayoyi

Haɗin kai tare da wasu kwayoyi suna shafar hanyoyin tafiyar matakai da ke haɗuwa da glucose:

1. Wasu kwayoyi suna inganta tasirin Lantus. Waɗannan sun haɗa da sulfonamides, salicylates, maganin kwayoyi na rage ƙwayar glucose, ACE da hanawar MAO, da sauransu.
2. Diuretics, jinƙai mai juyayi, masu hana kariya, magungunan ƙwayoyin cuta guda ɗaya, kwayoyin - mata, thyroid, da sauransu sun raunana tasirin insulin glargine.
3. Yawan shan salts na sallar lithium, masu hana beta ko amfani da giya suna haifar da wani yanayi na rashin daidaituwa - haɓaka ko raunana sakamakon ƙwayar.
4. Shan pentamidine a layi daya tare da Lantus yana haifar da ragi a cikin matakan sukari, canjin mai kauri daga raguwa zuwa karuwa.

Gabaɗaya, maganin yana da sake dubawa tabbatacce. Nawa ne insulin glargin yake kashewa? Farashin kudade a yankuna ya kama daga 2500-4000 rubles.

Zamu bincika yadda ake amfani da Lantus - umarnin don amfani da shi yana cewa dole ne a shigar da ƙyalli a cikin kitsen mai a jikin bangon ciki, kuma ba za'a iya amfani da shi ba. Wannan hanyar kulawa da magunguna zai haifar da raguwa mai yawa a cikin matakan glucose na jini da haɓakar ƙwayar cutar hypoglycemic.

Baya ga fiber akan ciki, akwai sauran wurare don yiwuwar gabatarwar Lantus - tsohuwar ƙwaƙwalwar ƙwaƙwalwar fata, tsokoki. Bambancin tasiri a cikin waɗannan halayen ba shi da mahimmanci ko kuma ba ya nan gaba ɗaya.

Ba za a iya haɗa hormone ba lokaci guda tare da wasu magungunan insulin, ba za a iya narke shi ba kafin amfani dashi, saboda wannan yana rage tasiri sosai. Idan aka haɗu da wasu abubuwan magunguna, hazo zai yuwu.

Don samun ingantacciyar warkewar warkewa, ya kamata a yi amfani da Lantus a ci gaba, kowace rana a lokaci guda.

Wani nau'in insulin ya kamata a yi amfani dashi don ciwon sukari, ƙungiyar endocrinologist zata ba ku shawara. A wasu halaye, ana iya rarraba magungunan gajeriyar magana tare da su; wasu lokuta ya zama dole a hada duka gajere da na tsawan tsawo. Misalin irin wannan haɗin shine amfani da haɗin gwiwa na Lantus da Apidra, ko haɗuwa kamar Lantus da Novorapid.

A cikin waɗannan halayen lokacin da, saboda wasu dalilai, ana buƙatar canza miyagun ƙwayoyi Lantus Solostar zuwa wani (alal misali, zuwa Tujeo), dole ne a kiyaye wasu ƙa'idodi. Mafi mahimmanci, canji bai kamata ya kasance tare da babban damuwa ga jiki ba, don haka ba za ku iya rage yawan maganin ba bisa la'akari da adadin sassan aikin.

Akasin haka, a cikin kwanakin farko na gudanarwa, haɓaka yawan insulin da aka gudanar yana yiwuwa don guje wa hauhawar jini. Lokacin da duk tsarin jikin mutum ya canza zuwa ingantaccen amfani da sabon magani, zaku iya rage kashi zuwa dabi'un al'ada.

Duk canje-canje a cikin hanyar jiyya, musamman waɗanda ke da alaƙa da maye gurbin miyagun ƙwayoyi tare da analogues, yakamata a yarda da likitan halartar, wanda yasan yadda magani ɗaya ya bambanta da wani kuma wanne yafi tasiri.

Dole ne a sanar da bukatar yin amfani da wasu kungiyoyin magunguna don magani kafin a sanar da likitan halartar. Wasu kwayoyi, yin hulɗa tare da Lantus, suna inganta tasirin sa, yayin da wasu, akasin haka, suna hana shi, suna sa ya yiwu a sami ingantaccen magani.

Magunguna waɗanda ke haɓaka aikin Lantus:

• hanawa
• maganin rigakafi
• wani rukuni na salicylates, fibrates,
• Fluoxetine.

Gudanar da su a lokaci guda na iya haifar da tsalle tsalle a cikin sukari na jini da kuma mummunan harin glycemia. Idan ba zai yiwu a soke waɗannan kuɗi ba, ya zama dole don daidaita sashi na insulin.

Rage tasirin magungunan na iya faruwa yayin da yake hulɗa tare da magungunan diuretic, ƙungiyar estrogens da progestogens, da kuma maganin cututtukan cututtukan ƙwayoyin cuta na zamani. Magungunan Hormonal da aka yi niyya don magance cututtukan cututtukan cututtukan ƙwayar thyroid da tsarin endocrine na iya raunana tasirin hypoglycemic na Lantus.

An ba da shawarar sosai kada ku ci giya kuma kuyi amfani da magunguna na ƙungiyar beta-blocker don magani, wanda zai iya rage tasiri na miyagun ƙwayoyi da tsokani glycemia, dangane da sashi da halayen mutum na jikin mai haƙuri.

Abun hulɗa tsakanin miyagun ƙwayoyi tare da adadin kwayoyi na iya shafar metabolism metabolism. Wadannan kwayoyi suna shafar aikin Lantus bisa ga umarnin:

• Magunguna waɗanda ke haɓaka aikin Lantus (insulin glargine) - Inhibitors na ACE, magunguna na baki, MAO inhibitors, Fluxetine, fibrates, rashin biyayya, propoxyphene, pentoxifylline, magungunan sulfonamide da salicylates,
• Magunguna waɗanda ke raunana tasirin Lantus (insulin glargine) - GCS, diazoxide, danazole, diuretics, gestagens, estrogens, glucagon, isoniazid, somatotropin, phenothiazine derivatives, sympathomimetics (epinephrine, terbutaline, salbutamolise dinta cututtukan mahaifa
• Dukansu suna haɓakawa da raunana tasirin Lantus (insulin glargine) beta-blockers, salhi mai gishiri, clonidine, barasa,
• Rashin ƙarfin adadin glucose a cikin jini tare da canzawar hypoglycemia zuwa hyperglycemia na iya haifar da gudanarwar Lantus na lokaci guda tare da pentamidine,
• Alamomin adrenergic counterregulation na iya raguwa ko ba ya nan yayin shan magungunan tausayawa - guanfacin, clonidine, reserpine da beta-blockers.

Sashi da gudanarwa

Lantus® ya ƙunshi glargine insulin - analog na insulin tare da tsawan lokaci. Ya kamata a yi amfani da Lantus® sau ɗaya a rana, a kowane lokaci na rana, amma a lokaci guda, yau da kullun.

Za a zaɓi jigilar sashi (kashi da lokacin gudanarwa) na Lantus daban-daban. Ga marasa lafiya da ke fama da ciwon sukari na 2, za a iya amfani da Lantus® tare da magungunan antidiabetic na baka.

An bayyana ayyukan wannan magani a cikin raka'a. Waɗannan raka'a halayen ne kawai don Lantus kuma ba su yi kama da ME ba kuma raka'arorin da aka yi amfani da su don nuna ƙarfin aikin sauran analogs na insulin (duba. Magunguna Pharmacodynamics).

Tsofaffi marasa lafiya (≥ 65 shekara)

A cikin tsofaffi marasa lafiya, rage ci gaba a cikin aikin koda na iya haifar da raguwar ci gaba cikin bukatun insulin.

Paarancin aiki na haya

A cikin marasa lafiya da ke fama da rauni na aikin ƙirar, ana buƙatar rage insulin saboda ragewar metabolism din.

Paarancin aikin hepatic

A cikin marasa lafiya da ke fama da aikin hanta, buƙatar insulin na iya raguwa saboda rage ƙarfin gluconeogenesis da rage metabolism.

Aminci da tasiri na miyagun ƙwayoyi Lantus® an tabbatar dasu a cikin samari da yara 2 da suka manyanta (duba "Pharmacodynamics"). Ba a yi nazarin Lantus® a cikin yara 'yan shekara 2 ba.

Sauyawa daga sauran insulin zuwa Lantus®

Lokacin maye gurbin tsarin kulawa da insulin na matsakaici ko insulin aiki na tsawon lokaci tare da maganin Lantus, yana iya zama dole a canza sashin insulin basal kuma a daidaita maganin antidiabetic a lokaci guda (allurai da lokacin gudanar da ƙarin insulins na gajeran lokaci ko analogs na insulin, ko allurai na maganin antidiabetic drugs) kudade).

Don rage haɗarin dare ko sanyin safiya, marasa lafiya suna juyawa daga tsarin insulin guda biyu na NPH zuwa tsarin guda ɗaya tare da Lantus yakamata su rage yawan aikin yau da kullun na insal ɗin ta 20-30% a farkon makonni na jiyya.

A cikin makonni na farko, rage yawan kashi ya kamata a kalla a biya ɗan rago ɗaya ta hanyar ƙara yawan adadin insulin da aka yi amfani da shi yayin abinci, bayan wannan lokacin, ya kamata a daidaita hanyoyin su akayi daban-daban.

Kamar yadda yake tare da wasu analogs na insulin, a cikin marasa lafiya suna karɓar ƙwayar insulin sosai saboda kasancewar ƙwayoyin rigakafi ga insulin na mutum, yana yiwuwa a inganta amsawar insulin yayin jiyya tare da Lantus.

Lokacin canzawa zuwa Lantus® kuma a cikin farkon makonni bayan shi, ana buƙatar tsauraran sa ido kan alamu na rayuwa.

Yayinda sarrafawa na rayuwa ya inganta kuma, a sakamakon haka, hankalin jijiyoyin jiki ga insulin yana ƙaruwa, ana iya buƙatar ƙarin sakin sikelin. Yin gyare-gyare na matsakaici na iya zama dole, alal misali, tare da canji a jikin mai haƙuri ko salon rayuwa, tare da canji a lokacin gudanarwar insulin kuma tare da sauran, sabon yanayin da ke haifar da haɓakar haɓakar hypoglycemia ko hyperglycemia (duba “Umarni na Musamman”).

Lantus® yakamata a gudanar dashi ƙarƙashin abu. Bai kamata a gudanar da Lantus® a ciki ba. Tsawancin aikin Lantus ya kasance ne sakamakon gabatarwar shi cikin kitse mai ƙyalƙyali. Gudun cikin jijiya na kashin baya na yau da kullun na iya haifar da mummunan hypoglycemia. Babu wani bambanci mai mahimmanci a asibiti a cikin insulin insulin ko matakan glucose bayan gudanarwar Lantus zuwa bango na ciki, tsoka mai ƙoshin ciki, ko cinya. Wajibi ne don canja wurin allurar a cikin yanki ɗaya kowane lokaci. Kada a cakuda Lantus® tare da sauran insulin ko kuma mai nishi. Hadawa da dilution na iya canza tsarin bayanin lokaci / aiki; hadawa na iya haifar da hazo. Don cikakkun bayanai game da sarrafa magani, duba ƙasa.

Umarni na musamman don amfani

Za a yi amfani da katakan katako na musamman tare da OptiPen®, ClickSTAR®, Autopen® 24 alkalami (duba “Umarnin na Musamman”).

Umarnin mai sana'anta don kula da alkalami game da ɗimbin katuwar katako, allura, da injin insulin dole ne a kiyaye su sosai.

Idan alkalami na insulin ya lalace ko ba a aiki da shi (saboda lahani na inji), dole ne a watsar da shi kuma ya kamata a yi amfani da sabon alkalami na insulin.

Idan alkalami bai yi aiki da kyau ba (duba umarni don magance alkalami), to za a iya cire maganin daga kayan a cikin sirinji (raka'a 100 / ml da ya dace da insulin) da allura.

Kafin sakawa a cikin alkalami, yakamata a ajiye kicin din har tsawon awanni 1-2 a zazzabi na daki.

Binciken katun kafin amfani. Za'a iya amfani dashi kawai idan maganin shine a zahiri, mara launi, ba tare da tsayayyen abubuwan gani ba kuma yana da daidaito na ruwa. Tun da Lantus® bayani ne, ba ya buƙatar sake tayarwa kafin amfani.

Kada a cakuda Lantus® tare da kowane insulin ko kuma mai nishi. Haɗawa ko dilution na iya canza bayanin fasalinsa / fasalin aikinsa; hadawa na iya haifar da hazo.

Dole ne a cire kumburin iska daga kicin kafin allurar (duba umarnin riƙe). Ba za a iya cike kwandishan fanko ba.

Dole a yi amfani da alƙallan tare da katukan katako na Lantus®. Ya kamata a yi amfani da katakan katako na musamman tare da allon alkalami: OptiPen®, ClickSTAR® da Autopen® 24, bai kamata a yi amfani dasu tare da wasu allon alkalami ba, tunda daidaitattun dosing abin dogara ne kawai tare da alƙalumomin da aka jera.

Binciki vial kafin amfani. Za'a iya amfani dashi kawai idan maganin shine a zahiri, mara launi, ba tare da tsayayyen abubuwan gani ba kuma yana da daidaito na ruwa. Tun da Lantus® bayani ne, ba ya buƙatar sake tayarwa kafin amfani.

Kada a cakuda Lantus® tare da kowane insulin ko kuma mai nishi. Haɗawa ko tsarkewa na iya canza tsarin bayanansa / aikinsa; haɗawa na iya haifar da hazo.

Yana da mahimmanci koyaushe don bincika lakabin akan insulin kafin allurar, don kada ya rikitar da insulin glargine tare da sauran insulins (duba "Umarnin na Musamman").

Kuskuren tsarin kulawa da miyagun ƙwayoyi

An ba da rahoton maganganun lokacin da miyagun ƙwayoyi suka rikice tare da sauran insulins, musamman, ana gudanar da insulins na gajeren lokaci maimakon glargine bisa kuskure. Kafin kowane allura, ya zama dole a duba alamar insulin don gujewa rikicewa tsakanin insulin glargine da sauran insulins.

Haɗin Lantus tare da pioglitazone

Magungunan bugun zuciya an san su lokacin da aka yi amfani da pioglitazone a hade tare da insulin, musamman a cikin marasa lafiya da abubuwan haɗari don rashin zuciya. Wannan ya kamata a tuna dashi lokacin da ake rubuta jigon pioglitazone da Lantus. Idan an yi amfani da magani gabaɗaya, ya kamata a kula da marasa lafiya don alamun da alamun faduwar zuciya, hauhawar nauyi, da kumburi. Ya kamata a dakatar da Pioglitazone idan kowane alamun cutar zuciya ya tsananta.

Ba za a iya haɗa wannan maganin da sauran magunguna ba. Yana da mahimmanci cewa sirinji ba ya ƙunshi burbushi na wasu abubuwa.

Side effects

Hypoglycemia, mafi raunin da ya fi dacewa da maganin insulin, na iya haɓaka idan kashi na insulin ya yi yawa idan aka kwatanta da buƙatar insulin, abubuwa masu ƙarfi na hypoglycemia, musamman maimaitawa, na iya lalata tsarin juyayi. Tsawa ko tsauraran hare-hare na hypoglycemia na iya yin barazana ga rayuwar mai haƙuri. A cikin marasa lafiya da yawa, alamomin da alamun neuroglycopenia suna gab da alamun bayyanar cututtuka na adrenergic counterregulation. Gabaɗaya, yayin da aka ƙara saurin matakan glucose a cikin jini yana raguwa, daɗaɗɗar faɗakarwa shine sabon abu game da tsarin aiki da alamu.

Mu'amala da Lafiya

Abubuwa da yawa suna shafar metabolism kuma yana iya buƙatar daidaita sakin jiki na insulin glargine.

Abubuwan da zasu iya haɓaka tasirin glucose a cikin jini kuma suna iya ƙaruwa da haɗarin zuwa hypoglycemia sun hada da wakilan antidiabetic na baka, angiotensin-mai sauya enzyme inhibitors (ACEs), rashin biyayya, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOs), pentoxifylle prone;

Abubuwan da zasu iya raunana tasirin glucose-jini a cikin jini sun hada da hodar iblis na corticosteroid, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens da progestogens, abubuwan tarihin phenothiazine, somatropin, tausayi (misali, epinephrine (adrenaline), salbutol , magungunan rigakafi na gargajiya (misali, clozapine da olanzapine) da masu hana masu kariya.

Beta-blockers, clonidine, salts na lithium da barasa zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin a cikin jini. Pentamidine na iya haifar da hypoglycemia, wani lokacin kuma hyperglycemia yana biyo baya.

Bugu da ƙari, a ƙarƙashin rinjayar magunguna masu juyayi kamar β-blockers, clonidine, guanethidine da reserpine, alamun adrenergic counterregulation na iya zama mai rauni ko ba ya nan.

Ciki

Wanda aka nada nada kawai lokacin da ya zama tilas. Yana da mahimmanci a lura da matakin glucose a cikin jini da saka idanu akan yanayin matar mai juna biyu. A cikin watanni ukun farko, bukatar jikin insulin ya ragu, kuma cikin watanni shida masu zuwa sai ya tashi. Nan da nan bayan isar, bukatar wannan abun ya ragu sosai. Akwai haɗarin hauhawar jini.

Tare da lactation, shan maganin yana yiwuwa, amma a ƙarƙashin kulawa da kullun akan sashi. Glargin yana narkewa a cikin narkewar abinci kuma ya rushe zuwa cikin amino acid. Ba ya cutar da jariri lokacin shayarwa.

Sauyawa zuwa Lantus daga wasu nau'ikan insulin

Idan mara lafiya a baya ya ɗauki magunguna na tsaka-tsaki da tsaka-tsakin yanayi na aiki, to lokacin da ya sauya sheka zuwa Lantus, daidaita kashi na babban insulin ya zama dole. Har ila yau, za a sake nazarin hanyoyin kwantar da hankali.

Lokacin da aka canza allura guda biyu na insulin basal (NPH) zuwa allurar guda biyu na Lantus, kashi na farko yana raguwa zuwa 20-30%. Ana yin wannan a cikin kwanakin farko na 20 na far. Wannan zai taimaka wajen hana barayin jiki da daddare da safe. A wannan yanayin, kashi ana sarrafawa kafin abinci ya ƙaru. Bayan makonni 2-3, ana aiwatar da gyaran adadin abu abu daban-daban ga kowane mai haƙuri.

A cikin jikin wasu marasa lafiya, ana samar da rigakafi ga insulin na mutum. A wannan yanayin, amsawar rigakafi ga allurar Lantus tana canzawa. Hakanan yana iya buƙatar sake nazarin kashi.

Yin hulɗa tare da wasu kwayoyi

Magunguna daban-daban na iya inganta duka tasirin hypoglycemic na Lantus kuma yana raunana shi. Rukunin farko sun haɗa da magungunan ƙwayoyin cuta na rashin ƙarfi na jini, rashin biyayya, salicylates, propoxyphene, fluoxetine, antimicrobials na sulfonamide, inhibitors na monoamine, inbantan fibrates da pentoxifylline.

Tasirin rauni yana aiki ne ta hanyar danzole, hana haihuwa, diuretics, glucagon, isoniazid, protein inhibitors, epinephrine, hormone girma, salbutamol, phenothiazine, terbutaline, antipsychotics, hormones thyroid, diazoxide.

Wasu abubuwa suna da tasiri na ninki biyu akan kayan gulgine na hypoglycemic. Wadannan sun hada da pentamidine, beta-blockers, lithium salts, clonidine, barasa, guanethidine, reserpine. Twoayoyi biyu na ƙarshe da ke haifar da alamun bayyanar cututtukan hypoglycemia.

Lantus shine ɗayan farkon rashin lafiyar analogues na insulin ɗan adam. An samo shi ta hanyar maye gurbin amino acid asparagine tare da glycine a matsayi na 21 na sarkar A kuma ƙara amino acid arginine biyu a cikin sarkar B zuwa tashar amino acid ɗin. Wannan magungunan an samar dashi ne ta babban kamfanin samar da magunguna na Faransa - Sanofi-Aventis. A yayin binciken da yawa, an tabbatar da cewa insulin Lantus ba wai kawai yana rage haɗarin hypoglycemia ba idan aka kwatanta da magungunan NPH, amma yana inganta haɓakar metabolism. Da ke ƙasa akwai taƙaitaccen umarnin don amfani da sake dubawa game da masu ciwon sukari.

Abunda yake aiki na Lantus shine insulin glargine. An samo shi ta hanyar sake haifuwa ta amfani da ƙwayar k-12 na ƙwayar ƙwayar cuta ta Escherichia coli. A cikin yanayin tsaka tsaki, ya zama mai narkewa kaɗan, a cikin matsakaic acidic ya narke tare da ƙirƙirar microprecipitate, wanda a hankali a hankali yana sakin insulin. Sakamakon wannan, Lantus yana da tsarin ayyukan aiwatar da ingantaccen aiki wanda ya kasance har zuwa awanni 24.

Babban kayan magunguna:

• Sannu a hankali adsorption da kuma cikakken bayanin martaba cikin awa 24.
• Ressionarfafa garkuwar garkuwar jiki da narkewa a cikin tsopocytes.
• Abubuwan da ke aiki suna ɗaure wa masu karɓa na insulin sau 5-8 da ƙarfi.
• Gua'idar aikin glucose na metabolism, hanawar samuwar glucose a cikin hanta.

A cikin 1 ml Lantus Solostar ya ƙunshi:

• 3.6378 mg na insulin glargine (dangane da 100 IU na insulin mutum),
• 85% glycerol
• ruwa don yin allura
• hydrochloric maida hankali ne acid,
• m-cresol da sodium hydroxide.

Canji zuwa Lantus daga wasu insulin

Idan mai ciwon sukari yayi amfani da matsakaiciyar matsakaiciyar matsakaici, to idan aka canza zuwa Lantus, za'a canza sashi da tsarin maganin. Canjin insulin yakamata ayi a asibiti kawai.

A Rasha, duk masu ciwon sukari masu dogaro da kai sun canza shi daga Lantus zuwa Tujeo. Dangane da bincike, sabon maganin yana da ƙananan haɗarin haɓakar haɓakar jini, amma a aikace, yawancin mutane suna korafin cewa bayan canzawa zuwa Tujeo abincinsu ya yi tsalle sosai, don haka ana tilasta su sayi insulin Lantus Solostar da kansu.

Levemir ingantaccen magani ne, amma yana da kayan aiki daban, kodayake tsawon lokacin aiki shima awowi 24 ne.

Aylar bai gamu da insulin ba, umarnin ya ce Lantus iri daya ne, amma masana'anta sun fi araha.

Insulin Lantus yayin daukar ciki

Ba a gudanar da karatun ɗabi'a na Lantus tare da mata masu juna biyu. A cewar bayanan da ba a sani ba, maganin ba ya cutar da hanyar daukar ciki da yaran da kansa.

An gudanar da gwaje-gwajen ne akan dabbobi, lokacin da aka tabbatar da cewa insulin glargine bashi da sakamako mai guba kan aikin haihuwa.

Ana iya tsara Lantus Solostar mai juna biyu idan insulin NPH yana aiki. Iyaye mata masu zuwa yakamata su lura da sukarin su, saboda a cikin farkon farkon, bukatar insulin na iya raguwa, kuma a cikin na biyu da na uku.

Kada ku ji tsoron shayar da jariri nono; umarnin ba su da bayanin da Lantus zai iya shigar da shi cikin madara.

Yadda ake adanawa

Rayuwar shiryayye na Lantus shine shekaru 3. Kuna buƙatar adanawa a cikin duhu mai duhu daga kariya daga hasken rana a zazzabi na 2 zuwa 8. Yawancin lokaci wurin da ya fi dacewa shine firiji. A wannan yanayin, tabbatar da duba tsarin zafin jiki, saboda haramcin insulin Lantus ne haramtacce!

Tun da amfani na farko, ana iya adana miyagun ƙwayoyi na tsawon wata guda a wuri mai duhu a zazzabi da bai wuce digiri 25 (ba a cikin firiji). Karka yi amfani da insulin da ya ƙare.

Inda zaka siya, farashin

An bayar da maganin Lantus Solostar kyauta ta magani ta hanyar likitancin endocrinologist. Amma kuma hakan yana faruwa da mai ciwon sukari ya sayi wannan magani a kashin kansa a kantin magani. Matsakaicin farashin insulin shine 3300 rubles. A cikin Ukraine, za'a iya sayan Lantus na 1200 UAH.

Lantus wani aikin mutum ne wanda yake daukar lokaci mai tsawo.

Formaddamar da tsari da abun da ke ciki

Lantus an samar dashi ta hanyar samarda mafita ga gudanarwar subcutaneous: m, kusan babu launi ko mara launi (3 ml kowannan a cikin gilashin gilashin launi, 5 katako a cikin fakitin bakin, 1 fakitin a cikin kwali na kwali, 5 OptiClick tsarin katun a cikin wani kwali na kwali, 5 kowane Alkalami na OptiSet a aljihunan kwali).

Haliccin 1 ml na miyagun ƙwayoyi ya hada da:

• Abubuwa masu aiki: glargine insulin - 3.6378 MG (yayi dace da abun cikin insulin mutum - 100 PIECES),
• Abubuwan taimako: zinc chloride, metacresol (m-cresol), glycerol 85%, sodium hydroxide, acid hydrochloric, ruwa don allura.

Alamu don amfani

1. Manya da yara daga shekara 2 da ciwon sukari na 1.
2. Nau'in ciwon sukari na 2 na cutar siga (a yanayin rashin ingancin allunan).

A cikin kiba, haɗakar magani yana da tasiri - Lantus Solostar da Metformin.

Yin hulɗa tare da wasu kwayoyi

Akwai magungunan da ke shafar metabolism, yayin da suke ƙaruwa ko rage buƙatar insulin.

Rage sukari: wakilan maganin antidiabetic, sulfonamides, ACE inhibitors, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Sugarara yawan sukari: hodar iblis na thyroid, diuretics, juyayi, ƙwarin hana baki, abubuwan gado na phenothiazine, abubuwan hana kariya.

Wasu abubuwa suna da tasirin hypoglycemic duka da tasirin hyperglycemic. Wadannan sun hada da:

• beta blockers da lithium salts,
• barasa
• Clonidine (maganin hana cin jini).

Sashi da gudanarwa

An saita adadin Lantus da lokacin rana don gudanarwarsa daban-daban.

Ya kamata a gudanar da miyagun ƙwayoyi a karkashin subcutaneously (a cikin subcutaneous mai na kafada, ciki ko cinya) 1 lokaci kowace rana koyaushe a lokaci guda. Ya kamata a musanya wuraren da allurar ta kasance tare da kowace sabuwar hanyar Lantus a cikin wuraren da aka bada shawarar gudanarwa.

Wataƙila amfani da Lantus azaman monotherapy ko kuma a lokaci guda tare da wasu magunguna na hypoglycemic.

Lokacin canja wurin marasa lafiya tare da matsakaiciyar matsakaici ko dogon lokaci zuwa Lantus, yana iya zama dole don canza maganin antidiabetic therapy (allurai na maganin hypoglycemic magunguna, kazalika da tsarin kulawa da allurai na gajeran aiki ko kuma analogues) ko don daidaita yanayin yau da kullun na insulin insulin.

Lokacin canja wurin marasa lafiya daga nauyin insulin-isofan na biyu zuwa gudanarwa na Lantus a farkon makonni na jiyya, ya zama dole don rage yawan yau da kullun na insulin basal da 20-30% (don rage haɗarin hauhawar jini a cikin dare da farkon safiya). Don wannan lokacin, ragewa a cikin kashi na Lantus ya kamata a rama shi ta hanyar karuwar abubuwan insulin na gajeran lokaci kuma ya kamata a kara inganta tsarin sashi.

Yayin canzawa zuwa Lantus kuma a cikin farkon makonni bayan wannan, saka idanu a hankali game da glucose a cikin jini ya zama dole. Idan ya cancanta, daidaita tsarin sashi na insulin. Hakanan ana iya buƙatar daidaita yanayin zafin don wasu dalilai, alal misali, lokacin canza yanayin haƙuri da nauyin jiki, lokacin ranar sarrafa magunguna, ko a wasu yanayi da ke ƙara haɓakar haɗarin ci gaba da hauhawar jini ko hypoglycemia.

Bai kamata a gudanar da miyagun ƙwayoyi a cikin jijiya ba (zazzabin hypoglycemia mai ƙarfi na iya haɓaka). Kafin fara gabatarwar, kana buƙatar tabbatar cewa sirinji bai ƙunshi ragowar wasu kwayoyi ba.

Kafin amfani da OptiSet allon alkawuran da aka cika cike da silsila, kana buƙatar tabbatar da cewa mafita mara launi, m, yayi kama da ruwa a cikin kayan kwalliya kuma basu da isasshen barbashi mai gani. Za'a iya amfani da allura da suka dace da alkali na sirinji OptiSet. Don hana kamuwa da cuta, mutum ɗaya ne kawai yakamata yayi amfani da sirinji mai sakewa.

Hulɗa da ƙwayoyi

Don kara laulayi da qarancin ruwa da kuma bunkasa hypoglycemic sakamako na insulin iya baka hypoglycemic jamiái, fluoxetine, angiotensin tana mayar enzyme hanawa, fibrates, disopyramide, dextropropoxyphene, pentoxifylline, salicylates da sulfa antimicrobial jamiái (a cikin wannan harka iya bukatar gyara na insulin kashi).

Hotunan thyroid, diuretics, glucocorticosteroids, diazoxide, danazole, isoniazid, wasu antipsychotics (misali, clozapine ko olanzapine), glucagon, progestogens, estrogens, somatotropin, phenothiazine derivatives, sympathomoltamines (kamar, tausaiton inspemo). , masu hana masu kariya (a wannan yanayin, ana iya buƙatar daidaita sashin insulin).

Yin amfani da insulin lokaci guda tare da pentamidine na iya haifar da hypoglycemia, wanda za'a iya maye gurbin shi da hyperglycemia. Tare da amfani da Lantus lokaci guda tare da clonidine, beta-blockers, ethanol da salhi lithium, duka haɓaka da raguwa a cikin tasirin hypoglycemic na insulin yana yiwuwa.

Tare da amfani da lokaci guda na Lantus tare da kwayoyi masu juyayi (clonidine, beta-blockers, guanfacin da reserpine) tare da haɓakar hypoglycemia, raguwa ko rashin alamun adrenergic counterregulation mai yiwuwa ne.

Kada a cakuda Lantus ko a cakuda shi da sauran shirye-shiryen insulin ko tare da wasu magunguna. Lokacin da aka gurbata ko gauraya, bayanin ayyukansa akan lokaci na iya canzawa. Hakanan yana iya haifar da hazo.

Sharuɗɗan da yanayin ajiya

Adana a cikin duhu, inda isar yara a zazzabi na 2-8 ° C, kada a daskare.

Rayuwar shelf shine shekaru 3.

Bayan fara amfani da katako, tsarin katun katako na OptiClick da alkalami na OptiSet da aka cika kafin ya kamata a adana su a wuri mai duhu, daga isar yara, a yanayin zafi har zuwa 25 ° C a cikin kwalin katun.

Kada a sanyaya alkalami mai cike da OptiSet da aka riga aka cika dashi.

Kwanan ƙarewar Lantus a cikin katako, tsarin kabad ɗin OptiClick da alkalami mai ƙarfi na OptiSet da aka cika kafin amfani na farko - 1 watan.

An sami kuskure a cikin rubutun? Zaɓi shi kuma latsa Ctrl + Shigar.

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Lantus . Yana ba da ra'ayi daga baƙi zuwa shafin - masu amfani da wannan magani, da kuma ra'ayoyin kwararrun likitocin game da amfani da Lantus a cikin al'amuransu. Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Lantus analogues a gaban isassun tsarin analogues. Yi amfani da shi don kula da ciwon sukari-dogara da ciwon sukari mellitus a cikin manya, yara, har ma yayin daukar ciki da lactation. Abun da magani.

Lantus - Alama ce ta insulin mutum. An samu ta hanyar sake haduwa da kwayoyin halittar kwayar halitta ta DNA daga cikin jinsunan Escherichia coli (E. coli) (K12 damuwa). Yana da ƙananan solubility a cikin tsaka tsaki yanayi. A cikin abun da ke ciki na miyagun ƙwayoyi Lantus, yana narkewa gaba ɗaya, wanda yanayin acidic ke tabbatar dashi don maganin allura (pH = 4). Bayan gabatarwar cikin kitse na subcutaneous, mafita, saboda acidityrsa, yana shiga cikin juzu'ikan amsawa tare da samuwar microprecipitates, daga abin da ƙananan ƙwayar insulin glargine (abu mai aiki na shirye-shiryen Lantus) ake fitarwa kullun, yana samar da ingantaccen (ba tare da kololuwa ba) bayanin martaba na lokaci-lokaci, har ma da tsawon lokaci na aikin miyagun ƙwayoyi.

Hanyoyin da ke ɗaurewa ga masu karɓar insulin na insulin glargine da insulin na ɗan adam suna da kusanci. Glulin insulin yana da tasirin kwayar halitta mai kama da insulin halittar jini.

Babban mahimmancin aikin insulin shine tsari na metabolism metabolism. Insulin da analogues dinsu suna rage glucose jini ta hanyar karfafa glucose uptake ta tsokoki na waje (musamman kasusuwa da tsotse nama), tare da hana samuwar glucose a cikin hanta (gluconeogenesis). Insulin yana hana lipolysis adipocyte da proteolysis, yayin inganta haɓakar furotin.

Thearin lokacin aikin insulin glargine shine kai tsaye saboda ƙarancin sha, wanda ke ba da damar amfani da miyagun ƙwayoyi sau ɗaya a rana. Aikin farko a kan matsakaici shine 1 awa bayan sc gwamnati. Matsakaicin tsawon lokacin aiki shine sa'o'i 24, matsakaicin shine sa'o'i 29. Yanayin aikin insulin da analogues ɗin (alal misali, glargine na insulin) akan lokaci na iya bambanta sosai a cikin marassa lafiya daban kuma a cikin haƙuri ɗaya.

Tsawon lokacin da miyagun ƙwayoyi Lantus ya kasance ne saboda gabatarwarsa cikin kitsen subcutaneous.

Insulin glargine + magabata.

Binciken kwatancen na yawan kwantar da hankalin insulin glargine da insulin-isophan bayan gudanarwar subcutaneous a cikin jini a cikin mutane masu lafiya da marasa lafiya da ke dauke da cutar sankarar mahaifa sun bayyana sakin jiki da saurin daukar hankali, da kuma rashin yawan kwarin gwiwa a cikin glargine insulin idan aka kwatanta da insulin-isofan.

Tare da kulawar s / c na miyagun ƙwayoyi 1 lokaci kowace rana, daidaitaccen matsakaiciyar ƙwayar insulin glargine a cikin jini an samu kwanaki 2-4 bayan kashi na farko.

Tare da gudanarwa na ciki, rabin rayuwar insulin glargine da insulin na mutane suna kamantawa.

A cikin mutum a cikin kitse na subcutaneous, insulin glargine an rabu da shi daga motar carbonll (C-terminus) na sarkar B (sarkar beta) don samar da 21A-Gly-insulin da 21A-Gly-des-30B-Thr-insulin. A cikin plasma, glargine insulin da ba ya canzawa da kayan aikin share fage suna nan.

• ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da yara fiye da shekaru 6,
• ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da yara sama da shekaru 2 (don nau'in SoloStar).

Magani don ƙaramar hukumar subcutane (ridarukan katako na mil 3 a OptiSet da kuma allon alkalami na OptiKlik).

Magani don gudanar da aikin ƙarƙashin ƙasa (katako 3 ml a cikin alƙallan siririn Lantus SoloStar).

Umarnin don amfani da makirci na amfani

Lantus OptiSet da OptiKlik

Ana saita adadin maganin da lokacin rana don gudanarwarsa daban-daban. Ana gudanar da Lantus a ƙarƙashin ƙasa sau ɗaya a rana, koyaushe a lokaci guda. Ya kamata a saka Lantus cikin kitse na ciki, kafada ko cinya. Wuraren allurar ya kamata ya canza tare da kowane sabon tsarin magani a cikin wuraren da aka ba da shawarar don maganin kula da miyagun ƙwayoyi.

Za'a iya amfani da maganin a matsayin monotherapy, kuma a hade tare da sauran magungunan hypoglycemic.

Lokacin canja mai haƙuri daga insulins na tsawon lokaci ko matsakaici na aiki zuwa Lantus, yana iya zama mahimmanci don gyara sashin insulin na yau da kullun ko canza maganin antidiabetic (allurai da tsari na gudanarwa na insulins na gajeran lokaci ko analogues, da kuma magungunan maganganu na maganin hypoglycemic).

Lokacin canja mai haƙuri daga tsarin kulawa na insulin-isofan na biyu zuwa allurar guda ɗaya na Lantus, ya kamata a rage kashi na yau da kullun na insal ta hanyar 20-30% a farkon makonni na jiyya don rage haɗarin hauhawar jini a cikin dare da sanyin safiya. A wannan lokacin, rage yawan kashi na Lantus ya kamata a rama shi ta hanyar karuwar adadin insulin na gajeran lokaci, tare da daidaitawar mutum akan tsarin sashi.

Kamar yadda ake yi da sauran analogues na insulin ɗan adam, marassa lafiya da ke karɓar ƙwayoyi masu yawa sakamakon kasancewar ƙwayoyin rigakafi ga insulin na ɗan adam na iya samun karuwa a cikin martanin insulin lokacin da suka sauya sheka zuwa Lantus. Yayin aiwatar da sauyawa zuwa Lantus kuma a cikin farkon makonni bayansa, ana buƙatar saka idanu sosai akan glucose a cikin jini kuma, idan ya cancanta, gyaran hanyoyin sarrafa insulin.

Game da ingantacciyar ƙa'idar aiki na metabolism da kuma sakamakon karuwar haɓakar ƙwaƙwalwar insulin, ƙarin gyaran hanyoyin yin aikin zai iya zama dole. Hakanan ana iya buƙatar daidaita sikelin kashi, alal misali, lokacin canza nauyin mara haƙuri, salon rayuwa, lokacin rana don gudanar da magunguna, ko lokacin da wasu yanayi suka bayyana wanda ke taimakawa ƙara haɓakar tsinkayar ci gaban hauhawar jini ko hauhawar jini.

Bai kamata a gudanar da maganin ba iv. A / a cikin gabatarwar kashi na yau da kullun, wanda aka yi niyya don gudanar da sc, zai iya haifar da ci gaba da rashin ƙarfi na hypoglycemia.

Kafin gudanarwa, dole ne ka tabbata cewa sirinjin ba su da ragowar sauran kwayoyi.

Dokoki don amfani da sarrafa magani

OptiSet alkalannin sirinji da aka riga an cika su

Kafin amfani, bincika katun cikin alkairin sirinji. Yakamata a yi amfani da shi idan mafita a zahiri, mara launi, ba ya ƙunshi abubuwan daskararren abubuwa kuma, cikin daidaito, yayi kama da ruwa. Ba'a amfani da alkalannin sirinji na OptiSet marasa amfani don sake amfani kuma dole ne a hallaka su.

Don hana kamuwa da cuta, alkalami da aka riga aka cika kafin ya yi niyya don amfani da mai haƙuri ɗaya kuma ba za'a iya tura shi ga wani ba.

Mu'amala da OptiSet Syringe Pen

Don kowane amfani da zai biyo baya, yi amfani da sabon allura. Yi amfani da allura kawai waɗanda suka dace don alkalami na OptiSet.

Kafin kowane allura, yakamata a yi gwajin lafiya.

Idan aka yi amfani da sabon sirinji na OptiSet, ya kamata ayi amfani da shiri don amfani da gwajin ta amfani da rukunin 8 wanda masana'antun suka zaɓa.

Za'a iya jujjuya wa mai zaɓin sashi gwargwado.

Karka taɓa juya mai zaɓin kashi (canjin kashi) bayan danna maɓallin fara allura.

Idan wani mutum ya yi allura ga mai haƙuri, dole ne a kula da kulawa ta musamman don guje wa rauni na allura da kamuwa da cuta ta hanyar ƙwayar cuta.

Karka taɓa amfani da alkalami mai rauni na OptiSet da ya lalace, haka nan kuma idan ana zargin ɓarnar aiki.

Wajibi ne a sami ɗan hular OptiSet syringe na dabam idan an yi asara ko lalacewar wanda aka yi amfani dashi.

Bayan cire hula daga alkairin sirinji, bincika alamar akan ɗakin insulin don tabbatar da cewa ya ƙunshi insulin da ya dace. Ya kamata kuma a tabbatar da bayyanar insulin: maganin insulin yakamata ya zama sananne, mara launi, babu 'yankar daskararren abu mai kyau kuma yana da daidaito kamar ruwa. Kada ku yi amfani da alkalami na OptiSet idan maganin insulin yana da gajimare, ƙaiƙayi ko ya ƙunshi barbashi na kasashen waje.

Bayan cire murfin, a hankali kuma ka haɗa allura da alkalami na syringe.

Dubawa da shirye-shiryen alkairin sirinji don amfani

Kafin kowane allura, ya zama dole a duba shirye-shiryen alkairin sirinji don amfani.

Don sabon alkalami da ba a amfani dashi, mai nuna alamar ya kamata ya kasance a lamba 8, kamar yadda masana'anta suka saita.

Idan aka yi amfani da alkalami mai sirinji, mai watsa abin ya kamata a juya har sai alamar man ta tsaya a lamba 2. Mai nuna zai juya ta hanya daya kawai.

Ullissar maɓallin farawa gaba ɗaya don amfani. Kada a juya mai zaɓin kashi bayan an cire maɓallin farawa.

Dole ne a cire ƙananan ƙofofin allura na ciki da ciki. Ajiye murfin waje don cire allura da aka yi amfani da shi.

Yayin riƙe alkalami na syringe tare da allura yana nuna sama, a hankali matsi da insulin cikin yatsanka don iska kuzarin sama ya tashi zuwa allura.

Bayan haka, danna maɓallin farawa koyaushe.

Idan digo na insulin ya fito daga tip na allura, alkalami mai aiki da allura suna aiki daidai.

Idan digo na insulin bai bayyana ba a saman allura, ya kamata ku maimaita gwajin shiri na alkairin sirinji don amfani har sai insulin ta bayyana a saman allura.

Zaɓi na insulin kashi

Ana iya saita kashi 2 zuwa raka'a 40 a cikin karin raka'a 2. Idan ana buƙatar sashin da ya wuce raka'a 40, dole ne a gudanar dashi a cikin allura biyu ko fiye. Tabbatar kana da isasshen insulin don maganin ka.

Matsakaicin insulin mai saura akan kwandon shara don insulin yana nuna yadda kusan insulin ya rage a cikin ƙwayar sirinji ta OptiSet. Ba za a iya amfani da wannan sikelin don ɗaukar kashi na insulin ba.

Idan fistin baƙar fata yana farkon farkon tsiri mai launin, to, akwai kusan raka'a 40 na insulin.

Idan piston na baki yana ƙarshen ƙarshen tsiri mai launin to, akwai kimanin raka'a 20 na insulin.

Ya kamata a juya mai amfani da kashi har sai kibiya ta nuna alamar da ake so.

Insulin kashi na ci

Dole a jawo maɓallin farawa allurar zuwa iyaka don cika alkalami insulin.

Ya kamata a bincika ko kashi da ake so an tattara tarawa. Maɓallin farawa yana canzawa daidai da yawan insulin da ya rage a cikin tanlin insulin.

Maɓallin farawa yana ba ku damar bincika wane kashi ake kira. A yayin gwajin, dole ne a kiyaye maballin farawa. Layin ƙarshe da aka gani na ƙarshe akan maɓallin farawa yana nuna adadin insulin ɗin da aka ɗauka. Lokacin da aka riƙe maɓallin farawa, kawai saman wannan layin yana bayyane.

Personnelwararrun ƙwararrun ma'aikata ya kamata su bayyana dabarar allura ga mai haƙuri.

Allurar tana cikin allurar ƙarƙashin ƙasa. Ya kamata a matsi maɓallin fara allurar zuwa iyaka. Danna maɓallin dannawa zai tsaya lokacin da aka danna maɓallin fara allura duk yadda yakamata.Sannan, ya kamata a adana maɓallin fara allura har tsawan 10 kafin cire allura daga cikin fata. Wannan zai tabbatar da gabatarwar dukkan kashi na insulin.

Bayan kowace allura, sai a cire allura daga sirinji ya watsar. Wannan zai hana kamuwa da cuta, da kuma yaduwar insulin, da yawan iska da kuma yiwuwar toshewar allura. Ba za a iya sake amfani da allura ba.

Bayan haka, sa a kan hat don alkalami mai sirinji.

Ya kamata a yi amfani da katako tare da alkalami na OptiPen Pro1, kuma ya dace da shawarwarin da masana'antun na'urar suka bayar.

Umarnin don yin amfani da alkalami na OptiPen Pro1 game da shigarwa na katako, abin da aka makala allura, da allurar insulin ya kamata a bi daidai. Binciken katun kafin amfani. Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani. Kafin shigar da katun a cikin alkairin sirinji, ya kamata kabad ɗin ya kasance cikin zazzabi a ɗakin don awa 1-2. Kafin yin allura, cire kumburin iska daga kicin. Wajibi ne a bi umarnin sosai. Ba a sake amfani da akwatunan komai ba. Idan alkairin OptiPen Pro1 ya lalace, dole ne kar kuyi amfani da shi.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar tattara maganin daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Tsarin Kayan Tsarin Kaya

Tsarin katako na OptiClick shine katako mai gilashi wanda ke dauke da 3 ml na glargine bayani na insulin, wanda aka sanya shi cikin kwandon filastik mai ma'ana tare da kayan piston mai haɗe.

Ya kamata a yi amfani da tsarin kabad ɗin OptiClick tare da alkalami na OptiClick mai dacewa tare da umarnin yin amfani da shi.

Idan alkairin OptiClick ya lalace, maye gurbinsa da sabon.

Kafin shigar da tsarin katun a cikin alkalami na OptiClick, yakamata ya kasance a zazzabi a cikin ɗakuna na 1-2 hours. Ya kamata a bincika tsarin katun kafin shigarwa. Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani. Kafin yin allura, cire kumburin iska daga tsarin katun (kamar dai ta amfani da alƙaluma mai kaɗa). Ba a sake amfani da tsarin akwatinan fanko ba.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar rubuta mafita daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Don hana kamuwa da cuta, mutum ɗaya ne kawai yakamata ya yi amfani da alkalami na sake amfani da maimaitawa.

Lantus SoloStar ya kamata a gudanar da subcutaneously sau ɗaya a rana a kowane lokaci na rana, amma kowace rana a lokaci guda.

A cikin marasa lafiya da nau'in ciwon sukari na 2 na sukari, ana iya amfani da Lantus SoloStar a matsayin monotherapy kuma a hade tare da sauran magungunan hypoglycemic. Ya kamata a tantance abubuwan da ke tattare da glucose na jini, kazalika da allurai da lokacin gudanarwa ko gudanar da magunguna na hypoglycemic kuma a daidaita su daban-daban.

Hakanan ana iya buƙatar daidaita daidaituwa, misali, lokacin canza nauyin mara haƙuri, salon rayuwa, canza lokacin gudanarwa na kashi na insulin, ko a wasu yanayi waɗanda zasu iya ƙara tsinkaye zuwa haɓakar hypo-ko hyperglycemia. Duk wani canje-canje a cikin adadin insulin ya kamata a aiwatar da shi tare da taka tsantsan kuma a ƙarƙashin kulawar likita.

Lantus SoloStar ba insulin zaɓi bane don warkar da cutar ketoacidosis mai ciwon sukari. A wannan halin, zaɓi ya kamata a gabatar da / a cikin gabatarwar insulin gajere. A cikin tsarin kulawa tare da injections na basal da prandial insulin, kashi 40-60% na yau da kullun na insulin a cikin nau'in insulin glargine yawanci ana gudanar da shi don biyan bukatar insulin basal.

A cikin marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na mellitus suna ɗaukar magunguna na hypoglycemic don sarrafa bakin, maganin haɗin gwiwa yana farawa da kashi na insulin glargine 10 KUDI 1 sau ɗaya kowace rana kuma a cikin tsarin kulawa na gaba yana daidaita daidaituwa.

Canji daga jiyya tare da wasu magungunan cututtukan jini zuwa Lantus SoloStar

Lokacin canja mai haƙuri daga tsarin kulawa ta amfani da matsakaiciyar matsakaici ko tsawon lokacin aiki zuwa insimen magani ta amfani da shirye-shiryen Lantus SoloStar, yana iya zama dole don daidaita lamba (allurai) da lokacin gudanar da insulin gajere-gajeren lokaci ko kuma analog a cikin rana ko canza allurai na maganin ƙwaƙwalwar ƙwayar cuta.

Lokacin canja wurin marasa lafiya daga allura guda na insulin-isofan yayin rana zuwa guda na gudanar da magani a cikin rana, Lantus SoloStar baya canza yanayin farkon insulin (i.e., adadin Lantus SoloStar Units a kowace rana daidai yake da adadin ME insulin isofan kowace rana).

Lokacin canja wurin marasa lafiya daga gudanar da insulin-isophan sau biyu a rana zuwa guda allurar Lantus SoloStar kafin lokacin bacci don rage haɗarin hauhawar jini a cikin dare da farkon sa'o'i, farawa na yau da kullun na insulin glargine yawanci an rage shi da 20% (idan aka kwatanta da yau da kullun na insulin isophane), sannan a daidaita shi gwargwadon amsawar mara lafiyan.

Kada a cakuda Lantus SoloStar ko a cakuda shi da sauran shirye-shiryen insulin. Tabbatar cewa sirinjin ba ya ƙunsar sauran sauran ƙwayoyi. Lokacin haɗuwa ko tsarma, bayanin martaba na insulin glargine na iya canzawa akan lokaci.

Lokacin canzawa daga insulin mutum zuwa magani Lantus SoloStar kuma a cikin makonni na farko bayan shi, ana ba da kulawa mai kulawa da hankali (lura da yawan tasirin glucose a cikin jini) a ƙarƙashin kulawar likita, tare da gyara hanyoyin sarrafa insulin idan ya zama dole. Kamar yadda yake tare da wasu analogues na insulin ɗan adam, wannan gaskiya ne ga marasa lafiya waɗanda, saboda kasancewar ƙwayoyin rigakafi ga insulin ɗan adam, suna buƙatar yin amfani da babban insulin na mutum. A cikin irin waɗannan marasa lafiya, lokacin amfani da glargine na insulin, ana iya lura da ingantacciyar ci gaba game da martanin da zai shafi kulawar insulin.

Tare da ingantacciyar iko na sarrafawa da kuma haifar da karuwar jijiyoyin jiki zuwa insulin, yana iya zama dole don daidaita tsarin sashi na insulin.

Hadawa da kiwo

Kada a cakuda miyagun ƙwayoyi Lantus SoloStar tare da wasu insulins. Haɗawa na iya canza rabo na lokaci / sakamako na miyagun ƙwayoyi Lantus SoloStar, kazalika da haifar da hazo.

Groupsungiyoyin haƙuri na musamman

Ana iya amfani da miyagun ƙwayoyi Lantus SoloStar a cikin yara da suka girmi shekaru 2. Ba a yi amfani da amfani da yara a ƙarƙashin shekaru 2 ba.

A cikin tsofaffi marasa lafiya da masu ciwon sukari mellitus, ana bada shawarar yin amfani da allurai na farko matsakaici, jinkirin karuwarsu da kuma amfani da matsakaitattun matakan kulawa.

Ana amfani da miyagun ƙwayoyi Lantus SoloStar a matsayin allurar sc. Magungunan Lantus SoloStar ba an yi shi bane don gudanarwar jijiya.

Tsawon lokacin aikin insulin glargine ana lura dashi ne kawai lokacin da aka gabatar dashi cikin mai mai kitse. A / a cikin gabatarwar kashi na biyu subcutaneous kashi na iya haifar da mummunan hypoglycemia. Ya kamata a gabatar da Lantus SoloStar cikin kitse na cikin ciki, kafadu ko kwatangwalo. Wuraren allurar ya kamata ya canza tare da kowane sabon allura a cikin wuraren da aka ba da shawarar don kamfani na maganin. Kamar yadda yake dangane da sauran nau'ikan insulin, matakin sha, kuma, sakamakon haka, farawa da tsawon lokacin aikinsa, na iya bambanta ƙarƙashin tasirin ayyukan jiki da sauran canje-canje a yanayin mai haƙuri.

Lantus SoloStar bayani ne bayyananne, ba dakatarwa ba. Saboda haka, sake tayardawa kafin amfani ba a buƙatar. Idan ƙwayar sikiran Lantus SoloStar ba ta da matsala, ana iya cire gulingine insulin daga cikin katun a cikin sirinji (wanda ya dace da insulin 100 IU / ml) kuma a yi allurar da ta dace.

Sharuɗɗa don amfani da sarrafa alƙalami mai cike da farashi SoloStar

Kafin amfani na farko, dole ne a kiyaye alƙalin sirinji a zafin jiki a cikin 1-2 na sa'o'i 1-2.

Kafin amfani, bincika katun cikin alkairin sirinji. Yakamata a yi amfani da shi idan mafita a zahiri, mara launi, ba ya ƙunshi abubuwan daskararren abubuwa kuma, cikin daidaito, yayi kama da ruwa.

Ba a sake amfani da sirinjin SoloStar ba kuma dole ne a zubar dashi.

Don hana kamuwa da cuta, alƙalami guda ɗaya ya kamata yakamata ya yi amfani da shi kuma ba za a tura shi ga wani ba.

Kafin amfani da alƙalaran sirinji na SoloStar, karanta bayanan a hankali akan amfani.

Kafin kowane amfani, a hankali haɗa sabon allura zuwa maɓallin sirinji kuma gudanar da gwajin lafiya. Dole ne kawai a yi amfani da allura da suka dace da SoloStar.

Dole a yi taka tsantsan don kiyaye haɗari da ya shafi amfani da allura da kuma yiwuwar kamuwa da cuta.

A kowane hali ya kamata ku yi amfani da alkairin sirinjin SoloStar idan ya lalace ko kuma ba ku san cewa zai yi aiki yadda yakamata ba.

Kullum koyaushe kuna da alƙalaran alƙalami na sifofin SoloStar a hannu idan kun rasa ko lalata kwafin silsilar SoloStar da ke akwai.

Idan an adana allurar sirinjin SoloStar a cikin firiji, ya kamata a fitar da shi 1-2 hours kafin allurar da aka yi niyya don maganin zai iya ɗaukar zazzabi a ɗakin. Gudanar da insulin mai narkewa shine mafi zafi. Dole ne a lalata alkairin sirinji SoloStar da aka yi amfani dashi.

Dole ne a kiyaye alkairin sirinjin SoloStar daga ƙura da datti. Ana iya tsabtace waje na alkairin SoloStar sirinji ta hanyar goge shi da rigar rigar. Kada a nutsar a cikin ruwa, a matse kuma a sa mai alkairin SoloStar sirinji, domin wannan na iya lalata shi.

Alƙalin sirinji na SoloStar yayi daidai insulin insulin kuma yana da aminci don amfani. Hakanan yana buƙatar kulawa da hankali. Guji yanayi wanda lalacewar alƙawarin Silinsar SoloStar na iya faruwa. Idan kuna tsammanin lalacewar yanayin data kasance na alƙalmar sirinjin SoloStar, yi amfani da sabon alkalami na sirinji.

Mataki na 1. Kula da insulin

Kuna buƙatar bincika lakabin akan allon alkairin SoloStar don tabbatar da cewa ya ƙunshi insulin da ya dace. Don Lantus, alkalami na sirinji na SoloStar ya yi launin toka tare da maɓallin shunayya don yin allura. Bayan an cire maƙarƙen siririn sirinji, bayyanar insulin da ke ciki ana sarrafa shi: maganin insulin dole ne ya zama mai ma'ana, mara launi, ba ya ƙunshi isassun barbashi mai bayyane mai kama da ruwa mai daidaituwa.

Mataki na 2. Haɗa allura

Yi amfani kawai da allura da suka dace da SoloStar Syringe Pen. Don kowane allurar da ta biyo baya, koyaushe yi amfani da sabon allurar bakararre. Bayan cire hula, dole a saka allura a hankali akan almalin syringe.

Mataki na 3. Yin gwajin aminci

Kafin kowane allura, ya zama dole a gudanar da gwajin aminci kuma a tabbata cewa alƙalin sirinji da allura suna aiki sosai kuma an cire kumburin iska.

Auna kashi daya daidai da raka'a 2.

Dole ne a cire ƙananan ƙofofin allura na ciki da ciki.

Sanya alƙalin sirinji tare da allura sama, a hankali a matattar ƙwalin insulin tare da yatsanka don duk an nuna kumburin iska zuwa allura.

A latsa maɓallin allurar gabaɗaya.

Idan insulin ya bayyana a saman allura, wannan yana nufin cewa alkalami mai kaɗa da allura suna aiki daidai.

Idan insulin bai bayyana ba a saman allura, to za a iya maimaita mataki na 3 har sai insulin ta bayyana a saman allura.

Mataki 4. Yankan Sashi

Ana iya saita kashi tare da daidaito na 1 naúrar daga mafi ƙarancin (1 raka'a) zuwa matsakaicin adadin (raka'a 80).Idan ya zama dole a gabatar da kaso fiye da raka'a 80, to dole ne a bayar da 2 allurai

Wutar taga zata nuna “0” bayan kammala gwajin amincin. Bayan wannan, ana iya kafa kashi mai mahimmanci.

Mataki 5. Allura

Yakamata a sanar da mara lafiyar game da dabarar allura ta kwararrun likitoci.

Dole ne a saka allura a ƙarƙashin fata.

Ya kamata a matsi maɓallin allurar gabaɗaya. Ana riƙe shi a wannan matsayin na wani sakan 10 har sai an cire allura. Wannan yana tabbatar da gabatarwar kashi da aka zaɓa na insulin gabaɗaya.

Mataki 6. Ana cire da zubar da allura

A kowane hali, ya kamata a cire cire allurar bayan kowane allura. Wannan yana tabbatar da hana rigakafin cuta da / ko kamuwa da cuta, iska da ke shiga cikin akwati don insulin da yaduwar insulin.

Lokacin cirewa da zubar da allura, dole ne a yi taka-tsantsan taka tsan-tsan. Bi matakan da aka bayar na kariya na tsaro don cirewa da fitar da allura (alal misali, hanyar dabarar hannu ɗaya) don rage haɗarin haɗarin haɗari da allura da kuma hana kamuwa da cuta.

Bayan cire allura, rufe allon alkairin SoloStar da hula.

• hypoglycemia - yana haɓaka mafi yawan lokuta idan kashi na insulin ya wuce buƙatarta,
• "mara nauyi" sani ko asarar,
• cututtukan zuciya
• yunwa
• haushi
• gumi mai sanyi
• samarin
• karancin gani
• ma'asumi
• lipodystrophy,
• dysgeusia,
• myalgia
• kumburi
• halayen rashin lafiyan kai tsaye ga insulin (gami da sinadarin insulin glargine) ko kayan taimako na magunguna: jigilar fatar fata, angioedema, bronchospasm, jijiyoyin jini, tsawa,
• jan, ciwo, itching, amya, kumburi ko kumburi a wurin allurar.

• yara 'yan kasa da shekaru 6 don Lantus OptiSet da OptiKlik (a halin yanzu babu bayanan asibiti game da amfanin),
• shekarun yara har zuwa shekaru biyu na Lantus SoloStar (rashin bayanan asibiti game da amfani),
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Haihuwa da lactation

Tare da taka tsantsan, ya kamata a yi amfani da Lantus yayin daukar ciki.

Ga marasa lafiya da ke fama da cutar sankarar bargo ta haihuwa ko ta gestational, yana da muhimmanci a kula da ka’ida sosai a duk lokacin daukar ciki. A cikin watanni 1 na ciki na ciki, buƙatar insulin na iya raguwa, a cikin watanni na 2 da na 3 yana iya ƙaruwa. Nan da nan bayan haihuwa, buƙatar insulin ya ragu, sabili da haka haɗarin hauhawar jini yana ƙaruwa. A ƙarƙashin waɗannan yanayin, saka idanu a hankali game da glucose jini yana da mahimmanci.

A cikin nazarin dabbobi na gwaji, ba a sami bayanai na kai tsaye ko a kaikaice game da embryotoxic ko tasirin maganin insulin glargine ba.

Ba a sami gwajin gwajin asibiti ba na amincin miyagun ƙwayoyi Lantus yayin daukar ciki. Akwai shaidar amfani da Lantus a cikin mata masu ciki 100 masu ciwon sukari. Hanya da sakamako na ciki a cikin waɗannan marasa lafiya bai bambanta da waɗanda ke cikin mata masu juna biyu da masu ciwon sukari waɗanda suka sami sauran shirye-shiryen insulin.

A cikin mata yayin shayarwa, ana iya buƙatar gyaran insulin na tsarin insulin da abinci.

Yi amfani da yara

A halin yanzu babu bayanan asibiti game da amfanin a cikin yara 'yan ƙasa da shekaru shida.

Yi amfani da shi a cikin tsofaffi marasa lafiya

A cikin marasa lafiya tsofaffi, ci gaba mai lalacewa a cikin aikin koda na iya haifar da raguwa a cikin buƙatun insulin.

Lantus ba magani bane na zaɓin ketoacidosis na masu ciwon sukari. A irin waɗannan halaye, ana bada shawarar gudanar da aikin insulin na ɗan gajeran lokaci.

Sakamakon ƙarancin ƙwarewa tare da Lantus, ba zai yiwu a kimanta ƙimar ta da amincin kulawa da kula da marasa lafiyar da ke fama da cutar hanta ko marasa lafiya da ƙarancin rashin ƙarfi na koda.

A cikin marasa lafiya da ke fama da rauni aiki, bukatar insulin na iya raguwa saboda raunin tsarin kawar dashi. A cikin marasa lafiya tsofaffi, ci gaba mai lalacewa a cikin aikin koda na iya haifar da raguwa a cikin buƙatun insulin.

A cikin marasa lafiya da rashin isasshen hepatic, ana iya rage buƙatar insulin saboda raguwa a cikin ikon gluconeogenesis da biotransformation na insulin.

Dangane da rashin iya sarrafawa dangane da matakin glucose a cikin jini, haka kuma idan akwai wani ra’ayi na haɓaka hypo- ko hyperglycemia, kafin a ci gaba da aiwatar da tsarin magunguna, ya zama dole a bincika daidaiton yarda da tsarin kulawar da aka tsara, wuraren gudanar da magunguna da fasahar ƙwararrun allura. , yin la’akari da duk dalilai masu tasiri a kansa.

Lokacin haɓakawar hypoglycemia ya dogara da bayanin aikin aikin insulin da aka yi amfani dashi kuma saboda haka, ya canza tare da canji a tsarin kulawa. Sakamakon ƙaruwa a cikin lokacin da yake ɗauka don gudanar da aikin insulin na dogon lokaci lokacin amfani da Lantus, mutum yakamata yai tsammanin ƙananan yiwuwar haɓakar ƙonewar dare, alhali a farkon sa'o'in safiya wannan yiwuwar yana da girma. Idan hypoglycemia ya faru a cikin marasa lafiya da ke karɓar Lantus, yiwuwar rage gudu daga hypoglycemia saboda tsawan aikin insulin glargine ya kamata a yi la'akari.

A cikin marasa lafiya waɗanda a cikinsu sassan cututtukan hypoglycemia na iya samun ƙimar musamman na asibiti, gami da tare da matsanancin rauni na cututtukan hanji ko na jijiyoyin wuya (hadarin haɓaka bugun zuciya da rikicewar cututtukan ƙwayar cuta), kazalika da marasa lafiya tare da farfadowa na ƙwayar cuta, musamman idan ba su karɓar magani na hoto ba (haɗarin rushewar hangen nesa na ɓoyewar jini), ya kamata a lura da kulawa ta musamman kuma a kula sosai. jini.

Yakamata a gargadi marassa lafiya game da yanayi wanda alamomin bayyanar cututtukan hawan jini na iya raguwa, zama mara karfi ko kuma ba su cikin wasu rukunin hadarin, wadanda suka hada da:

• marasa lafiya waɗanda ke da tabbas ingantaccen tsari na glucose jini,
• marasa lafiya waɗanda ke inganta hypoglycemia a hankali
• tsofaffi marasa lafiya
• masu cutar neuropathy
• marasa lafiya da doguwar cutar sankarau,
• marasa lafiya da matsalar rashin hankalin
• marasa lafiya sun canza daga insulin na asalin dabba zuwa insulin na mutum,
• marasa lafiya da ke karbar magani tare da wasu kwayoyi.

Irin waɗannan yanayi na iya haifar da haɓakar rashin ƙarfi na hypoglycemia (tare da yiwuwar asarar hankali) kafin mai haƙuri ya fahimci cewa yana haɓaka hypoglycemia.

Idan aka lura da al'ada ko aka rage matakan haemoglobin, yana da muhimmanci a la'akari da yuwuwar haɓakar sabon yanayin tashin hankali wanda bai dace ba (musamman da daddare).

Yarda da haƙuri game da dosing regimens, abinci, da rage cin abinci, insulin amfani, da kuma sarrafa farkon bayyanar cututtuka na hypoglycemia na taimaka wajan rage raguwa cikin haɗarin haɗarin hauhawar jini. A gaban abubuwan da ke haifar da haɓakar haɗarin jini, musamman lura da hankali dole ne, saboda Ana iya buƙatar daidaita sirin insulin sashi. Wadannan abubuwan sun hada da:

• canza wurin gudanar da insulin,
• sensara ji da hankali ga insulin (alal misali, lokacin da ake kawar da abubuwan damuwa),
• sabon abu, ƙara ko tsawan aiki na jiki,
• cututtuka daga ciki tare da amai, gudawa,
• take hakkin abinci da abinci,
• Abinci mai tsallakewa
• shan giya
• wasu rikice-rikice na ungenshy endocrine (alal misali, hypothyroidism, karancin adenohypophysis ko adrenal cortex),
• gamsar da magani tare da wasu magunguna.

A cikin cututtukan cututtukan zuciya, ana buƙatar ƙarin kulawa da glucose jini. A yawancin lokuta, ana yin bincike don kasancewar jikin ketone a cikin fitsari, kuma ana buƙatar gyaran sashi na insulin na insulin koda yaushe. Bukatar insulin sau da yawa yana ƙaruwa. Marasa lafiya da ke ɗauke da ciwon sukari na 1 ya kamata su ci gaba da cinye aƙalla kaɗan na ƙwayoyin carbohydrates, koda lokacin cin abinci kawai a cikin ƙananan kima ko kuma a cikin rashin iya cin abinci, tare da amai. Wadannan marasa lafiya kada su daina sarrafa insulin.

Oral hypoglycemic jami'ai, ACE inhibitors, rashin biyayya, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, dextropropoxyphene, salicylates da maganin antioxidam na sulfonamide na iya haɓaka tasirin rashin lafiyar insulin da ƙara haɓakar yanayin ci gaban hauhawar jini. Tare da waɗannan haɗuwa, za'a iya buƙatar daidaita sashin insulin glargine.

Glucocorticosteroids (GCS), danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, phenothiazine derivatives, somatotropin, sympathomimetics (misali epinephrine, salbutamol, terbutaline), hormones, cinema, cinema ) na iya rage tasirin insulin. Tare da waɗannan haɗuwa, za'a iya buƙatar daidaita sashin insulin glargine.

Tare da amfani da miyagun ƙwayoyi na Lantus a lokaci guda tare da beta-blockers, clonidine, salhi na lithium, ethanol (barasa), duka haɓaka da raguwa a cikin tasirin hypoglycemic na insulin yana yiwuwa. Pentamidine lokacin da aka haɗo shi da insulin zai iya haifar da hypoglycemia, wanda wasu lokuta ana maye gurbinsu da hyperglycemia.

Tare da yin amfani da lokaci ɗaya tare da kwayoyi tare da sakamako na juyayi, kamar beta-blockers, clonidine, guanfacine da reserpine, raguwa ko rashi alamun alamun adrenergic counterregulation (kunnawa tsarin juyayi na juyayi) tare da haɓaka ƙarancin jini zai yiwu.

Kada a haɗo Lantus tare da sauran shirye-shiryen insulin, tare da wasu magunguna, ko kuma an lalata Lokacin haɗawa ko tsarma, bayanin ayyukansa na iya canzawa na tsawon lokaci, ƙari, haɗawa da wasu abubuwan insulins na iya haifar da hazo.

Analogues na miyagun ƙwayoyi Lantus

Tsarin analogues na mai aiki abu:

• Insulin glargine,
• Lantus SoloStar.

Analogs don tasirin warkewa (kwayoyi don lura da ciwon sukari na dogaro da sukari-mellitus):

• Aiki
• Anvistat
• Apidra
• B. Insulin
• Berlinsulin,
• Biosulin
• Glyformin
• Glucobay,
• Asarar insulin C,
• Dibikor
• Isofan insulin Gasar Cin Kofin Duniya,
• Iletin
• Insulin Isofanicum,
• Tekin insulin,
• Insulin Maxirapid B,
• Matsakaici insulin
• Insulin kwalliya,
• Insulin Ultralente,
• Insulin mai tsawo
• Insulin Alkairi,
• Insuman
• Intal
• Hadarin insulin C
• Levemir Penfill,
• Levemir Flexpen,
• Metformin
• Mikstard
• Monosuinsulin MK,
• Monotard
• NovoMiks,
• Lantakiya,
• Pensulin,
• Protafan
• Rinsulin
• Stylamine
• Thorvacard
• Tricor
• Ultratard
• Humalog,
• Humulin
• Harshen Cigapan
• Erbisol.

Idan babu analogues na miyagun ƙwayoyi don ƙwayar abu mai aiki, zaku iya danna hanyoyin da ke ƙasa zuwa cututtukan da maganin da ya dace ya taimaka daga kuma duba magungunan analogues na maganin warkewa.

Abun ciki, sakin saki

Don amfani mai inganci, ana fitar da miyagun ƙwayoyi a cikin nau'in mafita mara launi. Mafi mahimmancin abubuwan da ke ciki shine Glulin insulin.

Baya ga shi, maganin ya hada da:

• ruwa
• zinc chloride
• sodium hydroxide
• glycerol
• hydrochloric acid,
• metacresol.

Marasa lafiya na iya cin gajiyar ire-iren wannan magungunan kamar:

1. Tsarin OptiClick. An sanye shi da katako guda 5.
2. Syringe alkalami OptiSet. Yawan su a cikin kunshin shine 5 inji mai kwakwalwa.
3. Lantus Solostar. A wannan yanayin, ana sanya katunan cikin sirinji na alkalami. Gaba ɗaya, akwai alkalami 5 a cikin kunshin.

Ana amfani da miyagun ƙwayoyi a cikin hanyar injections na subcutaneous kuma kawai akan shawarar likita.

Manuniya da contraindications

Dole ne a yi amfani da miyagun ƙwayoyi ne kawai idan likitan likita ya wajabta shi. Ko da tare da binciken da ya dace, zai kasance da wahala sosai ga mai haƙuri ya gano ko magani da shi yana da kyau. Bugu da ƙari, saboda wasu fasalolin jikin mai haƙuri, Lantus na iya zama cutarwa, yana da kyau a gudanar da gwajin farko.

Babban mahimmancin amfani da wakilin da ke dauke da insulin shine cututtukan sukari. Yawancin lokaci ana amfani dashi azaman monotherapy. Amma akwai wasu lokuta waɗanda aka wajabta wasu magunguna ban da shi.

Daga cikin contraindications yawanci ana ambata:

• Shekarun mai haƙuri ba su wuce shekara 6 ba,
• hankali na jiki ga abun da ke ciki.

Wasu yanayi suna da rigima.

Wadannan sun hada da:

• ciki
• ciyar da nono
• cutar hanta
• koda mai aiki,
• tsufa.

Wadannan yanayi suna daga cikin iyakokin. Idan ya cancanta, za'a iya amfani da Lantus, amma dole ne a sarrafa glucose, tunda waɗannan nau'ikan marasa lafiya suna da haɗari musamman zuwa hypoglycemia.

Hanyoyin sakin da farashin maganin

Abubuwan da ke aiki da miyagun ƙwayoyi shine glargine na hormone. Hakanan kuma an kara wa wadanda suka kware a ciki: zinc chloride, hydrochloric acid, m-cresol, sodium hydroxide, ruwa don injections da glycerol. Wannan magani ya bambanta da sauran nau'ikan insulin a cikin yanayin sakinsa.

• OptiKlik - kunshin daya ya ƙunshi katako 5 na 3 ml kowane. Cartridges an yi su da gilashi mai haske.
• An yi amfani da alkalami mai sirinji, wanda aka yi amfani da shi kawai - tare da taɓa yatsa, an kuma tsara don 3ml.
• Lantus SoloStar katako yana dauke da 3 ml na abu. Wadannan katunan katunan ana saka su cikin alkalami mai kauri. Akwai irin waɗannan alkalami 5 a cikin kunshin, ana siyar da su ba tare da allura ba.

Wannan magani magani ne mai dadewa. Amma nawa ne insulin Lantus yake kashewa?

Ana siyar da maganin ta hanyar takardar sayan magani, ana rarraba shi sosai tsakanin masu ciwon sukari, matsakaicin farashinsa shine 3200 rubles.

Lokacin da mutum ya kamu da ciwon sukari, yana buƙatar amfani da allurar insulin. Wannan ya tayar da tambayoyi: wane kayan aiki zaba? Nawa ne magani kuma in za a zabi magani mai tsada? Shin akwai bambanci tsakanin Lantus da Solostar, wanne ne mafi kyau?

Sau nawa a rana don yin allura kuma menene tsakanin jurewa tsakanin injections? Za muyi la’akari da ɗayan magungunan zamani, yi ƙoƙarin gano abin da za su zaɓa - insulin glargine ko magani mai kama da su, da abin da farashinsu yake.

Lantus shine magani na insulin na zamani wanda aikinsa yana nufin rage glucose a cikin jiki. Glulin insulin shine babban aikin mai maganin, wanda ba shi da narkewa a cikin tsaka-tsakin ph kuma yana da cikakkiyar daidaituwa da insulin ɗan adam. Lantus da insulin glargine - sunaye 2 na miyagun ƙwayoyi. Yi la'akari da babban tanadi na umarnin don amfani da miyagun ƙwayoyi "insulin Lantus."

Kayan aiki shine mafita wanda babban sashin yana ƙarƙashin rinjayar yanayi na acidic na musamman. Saboda shi, cikakken rushewa yakan faru. Lokacin da aka yi amfani da subcutaneously, acid yana cikin neutralized, microvidencepients an kafa, daga gare su abu mai aiki yana fitowa cikin jini. Doananan allurai daga ciki suna shiga cikin jini, ban da haɓaka mai yawa a cikin matakan insulin.

Godiya ga microprecipitate, ƙwayar tana da tasirin gaske (daga rana ɗaya, sa'a daya bayan aikace-aikacen).

Yadda ake amfani da Lantus

A kan aiwatar da amfani, bi dokoki:

1. Gabatar da miyagun ƙwayoyi ana aiwatar da su a cikin ƙashin mara mai nauyi na cinya ko kafaɗa, gindi, bangon ciki na ciki. Ana amfani da miyagun ƙwayoyi sau ɗaya kowace rana, wuraren allura ya canza, kuma ana kiyaye madaidaiciya tazara tsakanin allurar.
2. Sashi da lokacin allura an yanke masu ne ta hanyar likita - waɗannan sigogi ɗaya ne. Ana amfani da miyagun ƙwayoyi shi kaɗai ko a hade tare da wasu magunguna waɗanda aka tsara don rage matakan glucose.
3. Maganin allurar ba a gauraye ko an cakuda shi da shirye shiryen insulin ba.
4. Magungunan suna aiki da kyau lokacin da ake sarrafawa a ƙarƙashin fata, saboda haka ba a ba da shawarar yin allura dashi a ciki ba.
5. Lokacin da mai haƙuri ya sauya zuwa glargine insulin, saka idanu a hankali game da matakan sukari na jini ya wajaba don kwanaki 14-21.

Lokacin canza maganin, ƙwararren likita ya zaɓi tsarin da aka tsara dangane da bayanan binciken mai haƙuri da la'akari da halayen jikinsa. Insulin hankalin insulin yana ƙaruwa akan lokaci saboda ingantaccen tsarin tafiyar da aiki, kuma farawar ƙwayoyi ya zama daban. Yin gyaran regimin shima wajibi ne don sauyawa a cikin nauyin jikin mutum, canza yanayin aiki, canje-canje kwatsam a rayuwar, wato, tare da abubuwanda zasu iya haifar da tsinkaye ga dabi'un glucose mai girma ko mara nauyi.

Yin hulɗa tare da wasu magunguna

Haɗin kai tare da wasu kwayoyi suna shafar hanyoyin tafiyar matakai da ke haɗuwa da glucose:

1. Wasu kwayoyi suna inganta tasirin Lantus. Waɗannan sun haɗa da sulfonamides, salicylates, maganin kwayoyi na rage ƙwayar glucose, ACE da hanawar MAO, da sauransu.
2. Diuretics, jinƙai mai juyayi, masu hana kariya, magungunan ƙwayoyin cuta guda ɗaya, kwayoyin - mata, thyroid, da sauransu sun raunana tasirin insulin glargine.
3. Yawan shan salts na sallar lithium, masu hana beta ko amfani da giya suna haifar da wani yanayi na rashin daidaituwa - haɓaka ko raunana sakamakon ƙwayar.
4. Shan pentamidine a layi daya tare da Lantus yana haifar da ragi a cikin matakan sukari, canjin mai kauri daga raguwa zuwa karuwa.

Gabaɗaya, maganin yana da sake dubawa tabbatacce. Nawa ne insulin glargin yake kashewa? Farashin kudade a yankuna ya kama daga 2500-4000 rubles.

Halayen analogues

Lokacin da ba zai yiwu ba don siyan Lantus, an zaɓi analog.

Kamar insulin glargine, levemir yana da sakamako na tsawon lokaci. Koyaya, bayanin aikin wakili bai sane da na Lantus ba.

Ana ɗaukar magungunan don ciwon sukari. Ba a son sanya Levemir ga mata masu juna biyu, yara a ƙarƙashin shekara biyu (a cewar wasu kafofin, shekara shida). Kyakkyawan ma'ana - shan Levemir ba ya haifar da ƙimar nauyi a cikin haƙuri. Wanne insulin don amfani - Lantus ko Levemir? Levemir kwalliya ce mai rahusawa ta Lantus, wacce ke da sabani game da sake dubawa. Idan an bayar da maganin ga mai haƙuri ta jihar kuma babu korafi game da amfani, zaɓin a bayyane yake. Nawa ne kudin Levemir a cikin kantin magani? Farashin ya bambanta daga 300-500 zuwa 2000-300 rubles. ya danganta da irin sakin da adadin kwalaben. Idan ka zabi insalin lantus, farashin zai yi matukar girma.

Solostar cikakke ne analog na Lantus, wanda ke da alaƙa iri ɗaya da contraindications. An wajabta maganin ga yara kanana shekaru 2. Idan kun kwatanta insulin Lantus da Solostar, sake dubawa game da su zasu zama iri ɗaya. Don yin zaɓin, kula da farashin Solostar. Matsakaicin farashin magani yana da girma - daga 400-500 zuwa 4000 rubles. ya danganta da fasaha na kayan samarwa da yawan sa.

Don haka, maɓalli kaɗan. Yin amfani da magunguna na tsawan lokaci ya dace, amma kar a rubuta wa kanku magunguna - wannan shine prerogative na likita. Bayan gano yadda insulin Lantus yake kashewa, kuyi amfani da analogues idan sun dace da shari'ar ku. Solostar ba mafi muni ba don amfani, amma mai rahusa.

Glargin 3.6378 MG, wanda ya dace da abubuwan insulin mutum 100 IU.

Mahalarta: m-cresol, zinc chloride, glycerol (85%), sodium hydroxide, hydrochloric acid, ruwa ga kuma.

Rukunin asibiti da magunguna: insulin aikin mutum

Insulin glargine kwatankwacin insulin mutum ne. An samu ta hanyar sake haduwa da kwayoyin halittar kwayar halitta ta DNA daga cikin jinsunan Escherichia coli (nau'in K12). Yana da ƙananan solubility a cikin tsaka tsaki yanayi. Ya narke gaba daya cikin samfurin Lantus, wanda ke cikin yankin acidic na tabbatar da allurar mafita (pH = 4). Bayan gabatarwa cikin kitse na subcutaneous, mafita, saboda acidityrsa, yana shiga cikin juzu'ikan amsawa tare da samuwar microprecipitates, daga wanda ake ƙaddamar da ƙananan ƙwayar insulin glargine koyaushe, yana samar da ingantaccen (ba tare da kololuwa ba) bayanin martaba na lokaci-lokaci, har ila yau yana ƙara tsawon samfurin.

Hanyoyin da ke ɗaurewa ga masu karɓar insulin na insulin glargine da insulin na ɗan adam suna da kusanci. Insulin glargine yana da tasirin halitta mai kama da insulin halittar jini.

Babban mahimmancin aikin insulin shine tsarin metabolism. Insulin da analogues dinsu suna rage glucose jini ta hanyar karfafa glucose uptake ta tsokoki na waje (musamman kasusuwa da tsotse nama), yayin kuma yana hana samuwar glucose a cikin hanta (gluconeogenesis). Insulin yana hana lipolysis adipocyte da proteolysis, yayin inganta haɓakar furotin.

Thearin lokacin aikin insulin glargine shine kai tsaye saboda ƙarancin yawan shansa, wanda zai baka damar amfani da samfurin 1 lokaci / rana. Wanda yake farawa shine kusan - bayan awa 1 bayan gudanar da sc. Matsakaicin tsawon lokacin aiki shine sa'o'i 24, mafi tsawo - awanni 29. Yanayin aikin insulin da analogues ɗin (alal misali, insulin glargine) akan lokaci na iya bambanta sosai a cikin marassa lafiya daban daban kuma a cikin haƙuri ɗaya.

Tsawon lokacin da samfurin Lantus ya kasance ne sakamakon shigowarsa cikin kitse mai ƙarko.

Binciken kwatancen na yawan kwantar da hankalin insulin glargine da insulin-isophan bayan sc gwamnati a cikin jini na mutane masu lafiya da marasa lafiya tare da saukar da hankali sosai da kuma daukar lokaci mai tsawo, haka nan kuma rashin wadatar hankali a cikin insulin glargine idan aka kwatanta da insulin-isofan.

Lokacin da s / zuwa gabatarwar samfurin 1 lokaci / rana, an sami daidaitaccen matsakaiciyar ƙwayar insulin glargine a cikin jini bayan kwanaki 2-4 bayan gabatarwar kashi na farko.

Tare da kunnawa / a cikin gabatarwar T1 / 2, glargine insulin da insulin na mutum suna kamantawa.

A cikin mutum a cikin kitse na subcutaneous, insulin glargine an rabu da shi daga motar carbonll (C-terminus) na sarkar B (sarkar beta) don samar da 21A-Gly-insulin da 21A-Gly-des-30B-Thr-insulin. A cikin plasma, glargine insulin da ba ya canzawa da kayan aikin share fage suna nan.

• 
  ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da jarirai sama da shekaru 6 da haihuwa.

Ana saita adadin samfurin da lokaci na rana don gudanarwarsa daban-daban. Ana gudanar da Lantus s / c 1 lokaci / rana koyaushe a lokaci guda. Ya kamata a gabatar da Lantus cikin kitse na ciki, kafada ko cinya. Wuraren allurar ya kamata ya canza tare da kowane sabon gabatarwar samfurin a cikin wuraren da aka bada shawarar don sc gudanar da samfurin.

A cikin nau'in 1 na ciwon sukari, ana amfani da samfurin a matsayin babban insulin.

A cikin nau'in 2 na ciwon sukari na mellitus, ana iya amfani da samfurin duka azaman monotherapy kuma a hade tare da sauran samfuran hypoglycemic.

Lokacin canja mai haƙuri daga insulins na tsawon lokaci ko matsakaici na aiki zuwa Lantus, yana iya zama mahimmanci don daidaita suturar yau da kullun na insal basal ko canza maganin antidiabetic therapy (allurai da tsari na gudanarwar insulins na gajeran lokaci ko analogues ɗin su, tare da allurai na samfuran hypoglycemic na fata). Lokacin canja mai haƙuri daga tsarin kulawa na insulin-isophan zuwa allurar guda ɗaya na Lantus, ya kamata a rage kashi na yau da kullun na insal ta hanyar 20-30% a farkon makonni na jiyya don rage haɗarin hauhawar jini a cikin dare da sanyin safiya.A cikin wannan lokacin, rage yawan kashi na Lantus ya kamata a rama shi ta hanyar karuwar adadin insulin-gajeran lokaci, kuma a ƙarshen zamani, ya kamata a daidaita tsarin aikin sashi daban-daban.

Kamar yadda ake yi da sauran analogues na insulin na mutum, a cikin marassa lafiyar da suke karɓar ƙwayoyi masu yawa sakamakon kasancewar ƙwayoyin rigakafi ga insulin ɗan adam, ana iya lura da haɓakawa game da kulawar insulin lokacin da ake canzawa zuwa Lantus. Yayin aiwatar da sauyawa zuwa Lantus kuma a cikin makonni na farko bayan haka, ana buƙatar saka idanu sosai akan glucose jini.

Game da ingantacciyar ƙa'idar aiki na metabolism da kuma sakamakon karuwar haɓakar ƙwaƙwalwar insulin, ƙarin gyaran hanyoyin yin aikin zai iya zama dole. Hakanan ana iya buƙatar daidaita daidaituwa, misali, lokacin canza nauyin mara haƙuri, salon rayuwa, lokacin rana don gudanar da samfuran, ko lokacin da wasu yanayi suka taso wanda ke ƙara haɓakar tsinkayar zuwa hauhawar hypo- ko hyperglycemia.

Bai kamata a gudanar da maganin ba iv. A / a cikin gabatarwar kashi na yau da kullun, wanda aka yi niyya don gudanar da sc, zai iya haifar da ci gaba da rashin ƙarfi na hypoglycemia.

Kafin gudanarwa, dole ne ka tabbata cewa sirinjin ba su da ragowar sauran kwayoyi.

Abubuwan da ke tattare da sakamako masu dangantaka da sakamako akan metabolism metabolism: haɓaka mafi yawan lokuta idan kashi na insulin ya wuce buƙatar shi.

Hare-hare na mummunan hypoglycemia, musamman maimaituwa, na iya haifar da lalacewar tsarin juyayi. Abubuwa na tsawan lokaci da matsanancin rashin ƙarfi na iya haifar da barazanar rayuwar marasa lafiya.

Bayyanar cututtuka ta tsarin adrenergic counter (kunnawa a cikin tsarin juyayi-adrenal a cikin martani ga hypoglycemia) yawanci yana haifar da rikicewar neuropsychiatric saboda cututtukan hypoglycemia (“faɗuwar rana” ko asara, ciwo mai narkewa): yunwar, tashin hankali, gumi mai sanyi (hawan jini da sauri kuma mafi mahimmancin jini ya hauhawa, mafi bayyanar cututtukan bayyananniyar tsarin adrenergic counter).

Daga gefen gabar hangen nesa: manyan canje-canje a cikin tsarin glucose a cikin jini na iya haifar da nakasar gani na wucin gadi sakamakon canje-canje a cikin kasusuwa na nama da kuma jujjuyawar kwayar ido.

Tsawon lokaci na daidaituwa na glucose na jini yana rage haɗarin ci gaban cututtukan cututtukan zuciya. A banbanta da ilimin insulin, tare da ratsa sauye-sauye a cikin glucose na jini, toshewar wani lokaci na wucin gadi yayin maganin cututtukan fuka-fuka. A cikin marasa lafiya da cututtukan fata na farfadowa wadanda ba a kula dasu musamman tare da photocoagulation, abubuwan da ke tattare da mummunan rashin ƙarfi na iya haifar da ci gaban hasara na yau da kullun.

Abubuwan da suka shafi gida: kamar kowane samfuri na insulin, ɗaukar insulin na cikin gida na iya jinkirta shi a cikin gida. A cikin gwaji na asibiti yayin aikin insulin tare da Lantus, an lura da lipodystrophy a cikin 1-2% na marasa lafiya, yayin da lipoatrophy ba halayyar komai ba. Sauyawar wuraren allurar allura a cikin sassan jiki wanda aka ba da shawarar kula da insulin na insulin zai iya taimakawa rage zafin wannan yanayin ko hana haɓakawa.

Harkokin halayen ƙwayar cuta: a lokacin gwaji na asibiti yayin aikin insulin ta amfani da Lantus, an lura da halayen rashin lafiyan a wurin allurar a cikin 3-4% na marasa lafiya - redness, pain, itching, urticaria, bugu ko kumburi. A mafi yawancin halayen, ana warware matsalolin kananan halaye na tsawon kwanaki zuwa makonni da yawa.

Allergic halayen da wani nan da nan nau'in insulin (gami da insulin glargine) ko kayan taimako na samfurin, kamar abubuwan da suka shafi fata, angioedema, jijiyoyin jini, girgiza, da wuya. Wadannan halayen na iya zama barazanar rayuwa.

Sauran: amfanin insulin na iya haifar da samuwar ƙwayoyin cuta a jikinta. A lokacin gwaji na asibiti a cikin rukunin marasa lafiya da aka bi da insulin-isofan da insulin glargine, an lura da samuwar ƙwayoyin cuta-insulin tare da insulin na mutum tare da mitar guda. A cikin lokuta mafi wuya, kasancewar irin waɗannan ƙwayoyin rigakafi ga insulin na iya buƙatar daidaita sashi don kawar da sha'awar ci gaban hauhawar jini.

Da wuya, insulin na iya haifar da jinkiri a cikin ƙwayar sodium da haɓakar edema, musamman idan ingantaccen ilimin insulin yana haifar da ci gaba a cikin ƙarancin ƙarancin hanyoyin tafiyar matakai.

• 
  yara 'yan kasa da shekaru 6 (a halin yanzu babu bayanan asibiti game da amfanin),
  
• 
  babban mai saukin kamuwa zuwa insulin glargine ko kuma kowane bangare na kayan taimako.

Yi hankali da amfani da Lantus yayin daukar ciki.

Haihuwa da lactation

Yi amfani da hankali lokacin amfani da Lantus yayin daukar ciki.

Ga marasa lafiya da ke fama da cutar sankarar bargo ta haihuwa ko ta gestational, yana da muhimmanci a kula da ka’ida sosai a duk lokacin daukar ciki. A cikin farkon lokacin ciki, bukatar insulin na iya raguwa; a cikin na biyu da na uku, yana iya karuwa. Nan da nan bayan haihuwar yara, an rage buƙatar insulin, sabili da haka haɗarin hauhawar jini yana ƙaruwa. A ƙarƙashin waɗannan yanayin, saka idanu a hankali game da glucose jini yana da mahimmanci.

A cikin nazarin dabbobi na gwaji, ba a sami bayanai na kai tsaye ko a kaikaice game da embryotoxic ko tasirin maganin insulin glargine ba.

Babu wani gwaji na asibiti da aka kula da lafiyar lafiyar samfurin Lantus yayin daukar ciki. Akwai bayanai game da amfani da Lantus a cikin mata masu ciki 100 masu ciwon sukari. Hanya da sakamako na ciki a cikin waɗannan marasa lafiya bai bambanta da waɗanda ke cikin mata masu juna biyu da masu ciwon sukari waɗanda suka karbi wasu samfuran insulin.

A cikin mata masu shayarwa, ana buƙatar buƙatar sashin insulin da kuma daidaita yanayin abinci.

Yi amfani da shi don aikin hanta mai rauni

Sakamakon ƙarancin ƙwarewa tare da Lantus, ba zai yiwu a kimanta tasirinsa da amincin su ba a cikin kulawar marasa lafiyar da ke fama da aikin hanta.

Yi amfani da shi don aikin keɓaɓɓiyar aiki

Sakamakon ƙarancin ƙwarewa tare da Lantus, ba zai yiwu a kimanta ƙimar aikinta da amincin jinya a cikin kulawar marasa lafiya da matsatsi ko rashin nasara na koda ba.

Lantus ba samfurin zabi bane don maganin ketoacidosis na masu ciwon sukari. A irin waɗannan halaye, ana ba da shawarar gudanar da insulin gajeriyar aiki.

Sakamakon ƙarancin ƙwarewa tare da Lantus, ba zai yiwu a kimanta ƙimar ta da amincin kulawa da kula da marasa lafiyar da ke fama da aikin hanta ko marasa lafiya da ƙarancin ƙarancin renal.

A cikin marasa lafiya da ke fama da rauni aiki, bukatar insulin na iya raguwa saboda raunin tsarin kawar dashi. A cikin marasa lafiya tsofaffi, ci gaba da ci gaba a cikin aikin koda na iya haifar da raguwa mai yawa a cikin bukatun insulin.

A cikin marasa lafiya da rashin isasshen hepatic, ana buƙatar rage insulin saboda raguwa a cikin ikon gluconeogenesis da biotransformation na insulin.

Dangane da rashin daidaiton iko a kan matakin glucose a cikin jini, haka kuma idan akwai wani ra’ayi ga ci gaban hypo- ko hyperglycemia, kafin a ci gaba da aiwatar da tsarin magunguna, ya zama dole a duba daidaito na bin ka'idojin kulawar da aka tsara, wuraren gudanar da samarwa da kuma ingantaccen gudanar da allurar, la'akari da duk abubuwan da suka dace da matsalar.

Lokacin haɓakawar hypoglycemia ya dogara da bayanin aikin aikin insulin da aka yi amfani dashi kuma saboda haka, ya canza tare da canji a tsarin kulawa.Saboda karuwa a cikin lokacin da yake ɗauka don gudanar da insulin aiki na dindindin yayin amfani da Lantus, mutum yakamata yai tsammanin ƙarancin haɓakar rashin bacci a cikin dare, yayin da a farkon sa'o'in safiya wannan yiwuwar yana iya ƙaruwa.

Marasa lafiya a cikin wanda cututtukan hypoglycemia na iya samun ƙimar musamman na asibiti, gami da tare da matsanancin rauni na jijiya ko jijiyoyin bugun zuciya (hadarin haɓaka bugun zuciya da rikicewar cututtukan ƙwayar cuta), har ma ga marasa lafiya da ke ɗauke da cutar farfadowa, musamman idan ba su karɓi magani tare da daukar hoto ba (haɗarin rushewar hangen nesa saboda hauhawar jini), dole a lura da kulawa ta musamman kuma a kula sosai. jini.

Marasa lafiya yakamata su lura da yanayin da hanyoyin magance cutar sikila za su iya canzawa, zama marassa fata ko kuma ba sa cikin wasu rukuni na haɗarin, waɗanda suka haɗa da:

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  marasa lafiya waɗanda suka inganta ingantaccen tsari na glucose jini,
  
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  marasa lafiya waɗanda a cikin jini na haɓaka a hankali,
  
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  tsofaffi marasa lafiya, - marasa lafiya tare da neuropathy,
  
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  marasa lafiya da doguwar cutar sankarau,
  
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  marasa lafiya da matsalar rashin hankalin
  
• 
  marasa lafiya da ke karbar magani tare da wasu kayayyakin magunguna.

Irin waɗannan yanayi na iya haifar da haɓakar rashin ƙarfi na hypoglycemia (tare da yiwuwar asarar hankali) kafin mai haƙuri ya fahimci cewa yana haɓaka hypoglycemia.

Idan aka lura da al'ada ko aka rage matakan haemoglobin, yana da muhimmanci a la'akari da yuwuwar haɓakar sabon yanayin tashin hankali wanda bai dace ba (musamman da daddare).

Yarda da haƙuri game da dosing regimens, abinci, da rage cin abinci, insulin amfani, da kuma sarrafa farkon bayyanar cututtuka na hypoglycemia na taimaka wajan rage raguwa cikin haɗarin haɗarin hauhawar jini. A gaban abubuwan da ke haifar da haɓakar haɗarin jini, musamman saka idanu a hankali wajibi ne, saboda Ana iya buƙatar daidaita sirin insulin sashi. Wadannan abubuwan sun hada da:

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  canza wurin gudanar da insulin,
  
• 
  increasedara yawan ji na ƙwarai zuwa insulin (alal misali, lokacin da ake kawar da abubuwan damuwa),
  
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  sabon abu, babba ko tsawaita aiki,
  
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  cututtuka daga ciki tare da amai, gudawa,
  
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  take hakkin abinci da abinci,
  
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  Abinci mai tsallakewa
  
• 
  shan giya
  
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  wasu rikicewar rikicewar endocrine (alal misali, karancin adenohypophysis ko adrenal cortex),
  
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  gamsar da magani tare da wasu magunguna.

A cikin cututtukan cututtukan zuciya, ana buƙatar ƙarin kulawa da glucose jini. A yawancin lokuta, ana yin bincike don kasancewar jikin ketone a cikin fitsari, kuma ana buƙatar gyaran sashi na insulin na insulin koda yaushe. Bukatar insulin ba ya ƙaruwa sau da yawa. Marasa lafiya tare da nau'in ciwon sukari na 1 ya kamata su ci gaba da cinye aƙalla a ɗan ƙaramin adadin carbohydrates, koda lokacin cin abinci kawai a cikin ƙananan kima ko kuma a cikin rashin iya cin abinci, har ma da amai. Wadannan marasa lafiya kada su daina sarrafa insulin.

Bayyanar cututtuka: mai tsanani kuma wani lokacin tsawan jini, na barazanar rayuwar mai haƙuri.

Jiyya: sassan jiki na matsakaici yawanci ana tsayar da su ta hanyar samar da carbohydrates cikin sauri. Yana iya zama dole a canza jadawalin sashi na samfurin, abinci ko aikin jiki.

Abubuwan da ke tattare da mummunan tashin hankali, tare da coma, rashi ko raunin jijiyoyin jini, suna buƙatar gudanarwa na ciki ko guguwar glucagon, kazalika da gudanar da aikin kwantar da hankula don magance ƙwaƙwalwar ƙwayar cuta. Ana buƙatar buƙatar ɗaukar carbohydrate na dogon lokaci da kulawa na ƙwararru, kamarsake dawowa daga rashin lafiyar na iya yiwuwa ne saboda ci gaban asibiti.

Tasirin hypoglycemic na insulin an inganta shi ta samfuran hypoglycemic na baka, ACE, fibrates, melopyramids, MAO inhibitors, propoxyphene, salicylates da sulfonamides.

Rikicin hypoglycemic na insulin an rage shi ta hanyar GCS, diazoxide, diuretics, glucagon, estrogens, gestagens, phenothiazine abubuwan, somatotropin, sympathomimetics (ciki har da epinephrine, terbutaline), hormones thyroid, kariya na hanawa, wasu antipsychotics (e.g., o.,,.

Beta-blockers, clonidine, salts na lithium da ethanol zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Pentamidine na iya haifar da hypoglycemia, alternating a wasu yanayi tare da hyperglycemia.

A ƙarƙashin rinjayar samfuran masu juyayi, irin su beta-blockers, clonidine, guanfacine da alamun adrenergic counter-regulation, na iya ko ba za su kasance ba.

Kada a cakuda Lantus tare da wasu samfuran insulin, tare da wasu magunguna ko diluted. Lokacin haɗawa ko tsarma, bayanin ayyukansa na iya canzawa na tsawon lokaci, ƙari, haɗawa da wasu abubuwan insulins na iya haifar da hazo.

Yanayin ajiya da lokaci

Ya kamata a adana katako na katako na OptiKlik da ƙananan katun daga isar yara, a cikin firiji, a zazzabi na 2 ° zuwa 8 ° C. Don kare daga haɗuwa ga haske, ya kamata a adana samfurin a cikin takaddun jakunkuna, kada a daskare. Tabbatar kwantena ba su da hulɗa kai tsaye tare da injin daskarewa ko fakiri mai sanyi.

Bayan fara amfani da shi, ya kamata a adana kayan katako na kere-kere da tsarin katun daga isa ga yara, kariya daga haske a zazzabi wanda bai wuce 25 ° C ba. Don kare daga haɗuwa ga haske, yakamata a adana samfurin a cikin takaddun jakunkuna.

Rayuwar shiryayye na kayan samfurin a cikin katako da kuma tsarin katun na OptiClick shine shekaru 3.

Rayuwar shiryayye na samfurin a cikin katako da tsarin katun bayan amfani na farko shine 4 makonni. An ba da shawarar cewa ranar da ta fara samfurin samfurin alama a kan lakabin.

Hankali!
Kafin amfani da maganin "Lantus (Lantus)" Wajibi ne a nemi likita.
An bayar da umarnin ne kawai don sanin kanka da ""Lantus (Lantus) ". Kamar labarin? Raba tare da abokanka a shafukan sada zumunta:

Sakin siffofin da marufi

Magani don subcutaneous management na 100 PIECES / ml

3 ml na bayani a cikin kabad na m, gilashi mara launi. An rufe akwatinan katako a gefe guda tare da daskararren bromobutyl kuma an yanke shi tare da filayen aluminium, a gefe guda tare da mai amfani da bromobutyl.

A kan katako guda 5 a cikin kayan marmari mai ɗaukar hoto daga fim na polyvinyl chloride da tsare aluminium.

Don 1 marfin murfin huda tare da umarnin don amfani da magani a cikin jihohi da yaren Rasha, saka a cikin kwali.

Magani don allurar subcutaneous 100 PIECES / ml

10 ml na bayani a cikin kwalaben bayyananniyar, gilashin launi, waɗanda aka rufe da ƙuƙwalwar chlorobutyl kuma an yi birgima tare da iyakoki na aluminum tare da iyakoki na kariya da aka yi da polypropylene.

Don kwalban 1, tare da umarnin amfani da magani a cikin jihohi da yaren Rasha, saka a cikin kwali.

Rayuwar shelf

Shekaru 2 (kwalban), shekaru 3 (kabad).

Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Insulin glargine kwatankwacin insulin mutum ne. An samu ta hanyar sake haduwa da kwayoyin halittar kwayar halitta ta DNA daga cikin jinsunan Escherichia coli (nau'in K12). Yana da ƙananan solubility a cikin tsaka tsaki yanayi. A matsayin ɓangare na shiri na Lantus ®, yana narkewa gabaɗaya, wanda yanayin acidic ya tabbatar da maganin allura (pH = 4). Bayan gabatarwar cikin kitse na subcutaneous, mafita, saboda acidityrsa, yana shiga cikin juzu'ization dauki tare da samuwar microprecipitates, daga abin da ake ƙaddamar da ƙananan ƙwayar insulin glargine koyaushe, yana samar da ingantaccen (ba tare da kololuwa) bayanin martaba na lokaci-lokaci ba, har ma da tsawon lokacin aiki na miyagun ƙwayoyi.

Hanyoyin da ke ɗaurewa ga masu karɓar insulin na insulin glargine da insulin na ɗan adam suna da kusanci. Glulin insulin yana da tasirin kwayar halitta mai kama da insulin halittar jini.

Babban mahimmancin aikin insulin shine tsari na metabolism metabolism. Insulin da analogues dinsu suna rage glucose jini ta hanyar karfafa glucose uptake ta tsokoki na waje (musamman kasusuwa da tsotse nama), tare da hana samuwar glucose a cikin hanta (gluconeogenesis). Insulin yana hana lipolysis adipocyte da proteolysis, yayin inganta haɓakar furotin.

Increasedarin lokacin aikin insulin glargine shine kai tsaye saboda ƙarancin sha, wanda ke ba da damar amfani da miyagun ƙwayoyi 1 lokaci / rana. Aikin farko a kan matsakaici shine 1 awa bayan sc gwamnati. Matsakaicin tsawon lokacin aiki shine sa'o'i 24, matsakaicin shine sa'o'i 29. Yanayin aikin insulin da analogues ɗin (alal misali, glargine na insulin) akan lokaci na iya bambanta sosai a cikin marassa lafiya daban kuma a cikin haƙuri ɗaya.

Tsawon lokacin da miyagun ƙwayoyi Lantus ® ya kasance ne sakamakon shigowarsa cikin kitse mai ƙarko.

Nazarin kwatancen kwantar da hankali na insulin glargine da insulin-isofan bayan sc gudanarwa a cikin jini na mutane masu lafiya da marasa lafiya da ke dauke da cutar sankarau sun bayyana a hankali sosai da kuma daukar lokaci mai tsawo, haka nan kuma kasancewar ba a cikin yawan kwantar da hankali a cikin glargine insulin idan aka kwatanta da insulin-isofan.

Tare da kulawar s / c na miyagun ƙwayoyi 1 lokaci / rana, daidaitaccen matsakaiciyar ƙwayar insulin glargine a cikin jini an cimma shi kwanaki 2-4 bayan kashi na farko.

Tare da kunnawa / a cikin gabatarwar glargine na insulin T 1/2 da insulin na mutum suna daidai.

A cikin mutum mai kitse mai ƙananan ciki, insulin glargine an rabu da shi daga ƙarshen carbonxyl (C-terminus) na sarkar B (sarkar beta) don samar da 21 A -Gly-insulin da 21 A -Gly-des-30 B -Thr-insulin . A cikin plasma, glargine insulin da ba ya canzawa da kayan aikin share fage suna nan.

- ciwon sukari mellitus wanda ke buƙatar maganin insulin a cikin manya, matasa da yara sama da shekaru 6.

Ana saita adadin maganin da lokacin rana don gudanarwarsa daban-daban. Ana gudanar da Lantus ® s / c 1 lokaci / rana koyaushe a lokaci guda. Ya kamata a shigar da Lantus into cikin ƙashin ciki mai ƙyalli na ciki, kafada ko cinya. Wuraren allurar ya kamata ya canza tare da kowane sabon tsarin magani a cikin wuraren da aka ba da shawarar don maganin kula da miyagun ƙwayoyi.

Za'a iya amfani da maganin a matsayin monotherapy, kuma a hade tare da sauran magungunan hypoglycemic.

Lokacin canja mai haƙuri daga insulins na tsawon lokaci ko matsakaici na aiki zuwa Lantus ®, yana iya zama mahimmanci don daidaita suturar yau da kullun na insal basal ko canza maganin antidiabetic therapy (allurai da tsarin kulawa na insulins-gajere insulins ko analogues, da kuma allurai na maganin hypoglycemic kwayoyi).

Lokacin canja mai haƙuri daga tsarin kulawa na insulin-isofan na biyu zuwa allurar guda ɗaya na Lantus, ya kamata a rage kashi na yau da kullun na insal ta hanyar 20-30% a farkon makonni na jiyya don rage haɗarin hauhawar jini a cikin dare da sanyin safiya. A wannan lokacin, rage yawan kashi na Lantus ya kamata a rama shi ta hanyar karuwar adadin insulin na gajeran lokaci, tare da daidaitawar mutum akan tsarin sashi.

Kamar yadda ake yi da sauran analogues na insulin ɗan adam, marassa lafiya da ke karɓar ƙwayoyi masu yawa sakamakon kasancewar ƙwayoyin rigakafi ga insulin na ɗan adam na iya samun karuwa a cikin martanin insulin lokacin da suka sauya sheka zuwa Lantus ®. Yayin aiwatar da sauyawa zuwa Lantus ® kuma a cikin makonni na farko bayan shi, ana buƙatar saka idanu sosai akan glucose a cikin jini kuma, idan ya cancanta, gyaran hanyoyin sarrafa insulin.

Game da ingantacciyar ƙa'idar aiki na metabolism da kuma sakamakon karuwar haɓakar ƙwaƙwalwar insulin, ƙarin gyaran hanyoyin yin aikin zai iya zama dole.Hakanan ana iya buƙatar daidaita sikelin kashi, alal misali, lokacin canza nauyin mara haƙuri, salon rayuwa, lokacin rana don gudanar da magunguna, ko lokacin da wasu yanayi suka bayyana wanda ke taimakawa ƙara haɓakar tsinkayar ci gaban hauhawar jini ko hauhawar jini.

Bai kamata a gudanar da maganin ba iv. A / a cikin gabatarwar kashi na yau da kullun, wanda aka yi niyya don gudanar da sc, zai iya haifar da ci gaba da rashin ƙarfi na hypoglycemia.

Kafin gudanarwa, dole ne ka tabbata cewa sirinjin ba su da ragowar sauran kwayoyi.

Dokoki don amfani da sarrafa magani

OptiSet alkalannin sirinji da aka riga an cika su

Kafin amfani, bincika katun cikin alkairin sirinji. Yakamata a yi amfani da shi idan mafita a zahiri, mara launi, ba ya ƙunshi abubuwan daskararren abubuwa kuma, cikin daidaito, yayi kama da ruwa. Ba'a amfani da alkalannin sirinji na OptiSet marasa amfani don sake amfani kuma dole ne a hallaka su.

Don hana kamuwa da cuta, alkalami da aka riga aka cika kafin ya yi niyya don amfani da mai haƙuri ɗaya kuma ba za'a iya tura shi ga wani ba.

Mu'amala da OptiSet Syringe Pen

Don kowane amfani da zai biyo baya, yi amfani da sabon allura. Yi amfani da allura kawai waɗanda suka dace don alkalami na OptiSet.

Kafin kowane allura, yakamata a yi gwajin lafiya.

Idan aka yi amfani da sabon sirinji na OptiSet, ya kamata ayi amfani da shiri don amfani da gwajin ta amfani da rukunin 8 wanda masana'antun suka zaɓa.

Za'a iya jujjuya wa mai zaɓin sashi gwargwado.

Karka taɓa juya mai zaɓin kashi (canjin kashi) bayan danna maɓallin fara allura.

Idan wani mutum ya yi allura ga mai haƙuri, dole ne a kula da kulawa ta musamman don guje wa rauni na allura da kamuwa da cuta ta hanyar ƙwayar cuta.

Karka taɓa amfani da alkalami mai rauni na OptiSet da ya lalace, haka nan kuma idan ana zargin ɓarnar aiki.

Wajibi ne a sami ɗan hular OptiSet syringe na dabam idan an yi asara ko lalacewar wanda aka yi amfani dashi.

Bayan cire hula daga alkairin sirinji, bincika alamar akan ɗakin insulin don tabbatar da cewa ya ƙunshi insulin da ya dace. Ya kamata kuma a tabbatar da bayyanar insulin: maganin insulin yakamata ya zama sananne, mara launi, babu 'yankar daskararren abu mai kyau kuma yana da daidaito kamar ruwa. Kada ku yi amfani da alkalami na OptiSet idan maganin insulin yana da gajimare, ƙaiƙayi ko ya ƙunshi barbashi na kasashen waje.

Bayan cire murfin, a hankali kuma ka haɗa allura da alkalami na syringe.

Dubawa da shirye-shiryen alkairin sirinji don amfani

Kafin kowane allura, ya zama dole a duba shirye-shiryen alkairin sirinji don amfani.

Don sabon alkalami da ba a amfani dashi, mai nuna alamar ya kamata ya kasance a lamba 8, kamar yadda masana'anta suka saita.

Idan aka yi amfani da alkalami mai sirinji, mai watsa abin ya kamata a juya har sai alamar man ta tsaya a lamba 2. Mai nuna zai juya ta hanya daya kawai.

Ullissar maɓallin farawa gaba ɗaya don amfani. Kada a juya mai zaɓin kashi bayan an cire maɓallin farawa.

Dole ne a cire ƙananan ƙofofin allura na ciki da ciki. Ajiye murfin waje don cire allura da aka yi amfani da shi.

Yayin riƙe alkalami na syringe tare da allura yana nuna sama, a hankali matsi da insulin cikin yatsanka don iska kuzarin sama ya tashi zuwa allura.

Bayan haka, danna maɓallin farawa koyaushe.

Idan digo na insulin ya fito daga tip na allura, alkalami mai aiki da allura suna aiki daidai.

Idan digo na insulin bai bayyana ba a saman allura, ya kamata ku maimaita gwajin shiri na alkairin sirinji don amfani har sai insulin ta bayyana a saman allura.

Zaɓi na insulin kashi

Ana iya saita kashi 2 zuwa raka'a 40 a cikin karin raka'a 2. Idan ana buƙatar sashin da ya wuce raka'a 40, dole ne a gudanar dashi a cikin allura biyu ko fiye. Tabbatar kana da isasshen insulin don maganin ka.

Matsakaicin insulin mai saura akan kwandon shara don insulin yana nuna yadda kusan insulin ya rage a cikin ƙwayar sirinji ta OptiSet. Ba za a iya amfani da wannan sikelin don ɗaukar kashi na insulin ba.

Idan fistin baƙar fata yana farkon farkon tsiri mai launin, to, akwai kusan raka'a 40 na insulin.

Idan piston na baki yana ƙarshen ƙarshen tsiri mai launin to, akwai kimanin raka'a 20 na insulin.

Ya kamata a juya mai amfani da kashi har sai kibiya ta nuna alamar da ake so.

Insulin kashi na ci

Dole a jawo maɓallin farawa allurar zuwa iyaka don cika alkalami insulin.

Ya kamata a bincika ko kashi da ake so an tattara tarawa. Maɓallin farawa yana canzawa daidai da yawan insulin da ya rage a cikin tanlin insulin.

Maɓallin farawa yana ba ku damar bincika wane kashi ake kira. A yayin gwajin, dole ne a kiyaye maballin farawa. Layin ƙarshe da aka gani na ƙarshe akan maɓallin farawa yana nuna adadin insulin ɗin da aka ɗauka. Lokacin da aka riƙe maɓallin farawa, kawai saman wannan layin yana bayyane.

Personnelwararrun ƙwararrun ma'aikata ya kamata su bayyana dabarar allura ga mai haƙuri.

Allura yana allura sc. Ya kamata a matsi maɓallin fara allurar zuwa iyaka. Danna maɓallin dannawa zai tsaya lokacin da aka danna maɓallin fara allura duk yadda yakamata. Sannan, ya kamata a adana maɓallin fara allura har tsawan 10 kafin cire allura daga cikin fata. Wannan zai tabbatar da gabatarwar dukkan kashi na insulin.

Bayan kowace allura, sai a cire allura daga sirinji ya watsar. Wannan zai hana kamuwa da cuta, da kuma yaduwar insulin, da yawan iska da kuma yiwuwar toshewar allura. Ba za a iya sake amfani da allura ba.

Bayan haka, sa a kan hat don alkalami mai sirinji.

Ya kamata a yi amfani da katako tare da alkalami na OptiPen Pro1, kuma ya dace da shawarwarin da masana'antun na'urar suka bayar.

Umarnin don yin amfani da alkalami na OptiPen Pro1 game da shigarwa na katako, abin da aka makala allura, da allurar insulin ya kamata a bi daidai. Binciken katun kafin amfani. Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani. Kafin shigar da katun a cikin alkairin sirinji, ya kamata kabad ɗin ya kasance cikin zazzabi a ɗakin don awa 1-2. Kafin yin allura, cire kumburin iska daga kicin. Wajibi ne a bi umarnin sosai. Ba a sake amfani da akwatunan komai ba. Idan alkairin OptiPen Pro1 ya lalace, dole ne kar kuyi amfani da shi.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar tattara maganin daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Tsarin Kayan Tsarin Kaya

Tsarin katako na OptiClick shine katako mai gilashi wanda ke dauke da 3 ml na glargine bayani na insulin, wanda aka sanya shi cikin kwandon filastik mai ma'ana tare da kayan piston mai haɗe.

Ya kamata a yi amfani da tsarin kabad ɗin OptiClick tare da alkalami na OptiClick mai dacewa tare da umarnin yin amfani da shi.

Idan alkairin OptiClick ya lalace, maye gurbinsa da sabon.

Kafin shigar da tsarin katun a cikin alkalami na OptiClick, yakamata ya kasance a zazzabi a cikin ɗakuna na 1-2 hours. Ya kamata a bincika tsarin katun kafin shigarwa. Ya kamata ayi amfani dashi kawai idan maganin a bayyane yake, mara launi kuma baya dauke da abubuwan ɓoyayyen barbashi da ake gani.Kafin yin allura, cire kumburin iska daga tsarin katun (kamar dai ta amfani da alƙaluma mai kaɗa). Ba a sake amfani da tsarin akwatinan fanko ba.

Idan alkairin sirinji ba shi da kyau, idan ya cancanta, ana iya ba da insulin ga mara haƙuri ta hanyar rubuta mafita daga katun a cikin sinadarin filastik (wanda ya dace da insulin a taro na 100 IU / ml).

Don hana kamuwa da cuta, mutum ɗaya ne kawai yakamata ya yi amfani da alkalami na sake amfani da maimaitawa.

Dayyade yawan m halayen: sau da yawa (≥ 10%), sau da yawa (≥ 1%, Abun da miyagun ƙwayoyi

Babban sinadarin aiki na wannan magani shine glargine insulin, wanda yake a cikin kwayar 3.6378 mg. An fassara shi cikin insulin na mutum, wannan adadin yayi daidai da raka'a 100 na ƙasa da ƙasa. Baya ga abu mai aiki, abun da ke cikin maganin ya hada da abubuwan taimako. Wadannan sun hada da:

• metacresol
• zinc chloride
• glycerol
• sodium hydroxide
• hydrochloric acid maida hankali ne,
• tsarkakakken ruwa.

Musamman marasa lafiya

Wasu rukunin marasa lafiya suna buƙatar kulawa ta musamman lokacin zabar magani don magani. A gare su, kuna buƙatar ƙididdige yawan maganin kuma ku kula da tsarin aikin magani a hankali.

Wadannan marasa lafiya sun hada da:

1. Tsofaffi . Shekarun yana haifar da canje-canje da yawa a cikin aikin kwayoyin gaba ɗaya da na gabobin mutum musamman. A cikin mutane sama da 65, kodan da hanta ba su aiki kamar yadda yakamata a yawancin samari. Kuma cin zarafi a cikin aikinsu na iya haifar da mummunan yanayin hypoglycemic. Sabili da haka, amfani da Lantus ta irin waɗannan marasa lafiya yana buƙatar bin ka'idodi na kiyayewa. Suna rage kashi na miyagun ƙwayoyi, sukanyi nazari akan yadda ake aiki da ƙodan da hanta, kuma a koda yaushe suna duba haɗuwar glucose.
2. Yara . Ga jarirai yan kasa da shekaru 6, wannan magani ana ɗaukar shi haramun ne. Babu wani lamunin cutar da shi, amma saboda ba a amfani da shi ga kananan masu ciwon sukari. Ba a gudanar da cikakken bincike game da tasirin sa ga wannan rukuni na marasa lafiya ba.
3. Mata masu juna biyu . A wannan yanayin, wahalar ta kasance a cikin canje-canje akai-akai a matakan sukari da ke hade da ajalin. Idan akwai buƙatar yin ilimin insulin, ana amfani dashi, amma ana bincika jini koyaushe don haɗuwa da glucose, canza yanki na miyagun ƙwayoyi daidai da sakamakon.
4. Iyayen mata masu shayarwa . A gare su, wannan kayan aikin ma ba a haramta ba. Ba a kafa ta a cikin wata takaddar bincike ba ko Glargin ya wuce cikin madara. Amma idan ya shiga, to, a cewar likitocin, ba karamar hatsari ga jariri ba saboda yanayin sinadarinsa. Gargaɗi don irin wannan yanayi sun haɗa da daidaitawa da rage cin abinci. Wannan yana hana haɓakar bayyanar cututtuka.

Tare da abubuwan da aka lissafa na Lantus da aka lissafta, yana yiwuwa a yi magani tare da taimakonsa ya zama mai inganci kuma mai lafiya.

Ta wace hanya ake samar

Insulin Lantus wani ruwa ne wanda kwatankwacinsa yayi kama da ruwa. Kusan ba shi da launi, kuma an yi shi ne don gudanar da subcutaneous. Ana samun wannan magani ta hanyoyi guda uku.

Lantus SoloStar alkalami ne mai sirinji ba tare da allura ba, wanda a ciki aka girka wasu katako na gilashin gilashin cike da sinadarin insulin. Hannun harsashi an rufe su ta dukkan bangarorin, wanda ke kawar da ci gaba da iska a cikin mafita da zubewar sa.

Lantus Optiklik shine tsarin katun wanda aka gabatar a cikin hanyar katako wanda aka yi da gilashi mara launi. Waɗannan alamomin katako sun dace kawai don amfani dasu tare da alkalami na OptiClick syringe.

Lantus OptiSet shi ne sikirin da ba a rage shi ba tare da katako, wanda ke cike da mafita yayin samar da maganin.

Ba tare da la’akari da irin sakin maganin ba, karfin su iri daya ne kuma yana 3 ml.

Aiwatar da jiki

Lantus yana cikin rukunin ƙwayoyi tare da tasirin maganin cututtukan cututtukan da ke daɗewa. Abunda yake aiki, insulin glargine, an samo shi ta hanyar canza DNA na kwayoyin halittar Escherichia (nau'in K12), waɗanda Escherichia coli suke zaune cikin dabbobi masu dumin jini a cikin ƙananan hanji.

Ba za a iya narke wannan abun cikin tsaka tsaki ba. A cikin abun da ke cikin miyagun ƙwayoyi, ya narke gaba ɗaya saboda hydrochloric acid, wanda ke kula da yanayin acidic a cikin warwarewa.

Maganin an shigar dashi cikin kitse mai ƙyalli, inda iskar acid ke faruwa, wanda ke ba da gudummawa ga ƙirƙirar microprecipitate. Irin wannan halayen yana haifar da haifar da hazo mai kyau, wanda a hankali ya narke, yana sakin ƙananan sassan insulin glargine. Wannan fasalin na miyagun ƙwayoyi yana ba ku damar kula da ingantaccen matakin glucose a cikin jini na dogon lokaci, yana hana manyan canje-canje a matakinsa.

Insulin shine mafi mahimmancin hormone wanda ke daidaita metabolism a cikin jiki, yana samar da canjin glucose zuwa makamashi. A lokaci guda, yana da muhimmanci sosai cewa masu karɓa a cikin ƙwayoyin tsoka suna tsinkayen insulin da ke fitowa daga waje, kamar dai sinadarin horon da ke motsawa. Amfanin insulin glargine shine cewa tsarinta na canza masu karuwar insulin suna kama da insulin na mutum.

Insulin, kamar ta analogues, ba tare da asalinta ba, yana daidaita metabolism na metabolism kamar haka:

• taimakawa wajen canzawar glucose a cikin glycogen a cikin hanta,
• rage taro na glucose a cikin jini,
• samar da kama da aiki da glucose ta kasusuwa da tsoka nama,
• hana juyowa a cikin hanta na gllu daga fats da sunadarai.

Insulin ba wai kawai shine mai ba da makamashi ba, amma kuma magini ne wanda ke samar da sabon ƙwayoyin sel. Ana ba da wannan kadara ta hanyar tasiri mai zuwa:

• insulin yana haɓaka samarwar furotin ta hanyar ƙwayar tsoka,
• yana hana fashewar sunadarai,
• Yana ba da gudummawa ga samar da mai, samar da abinci mai narkewa na al'ada,
• yana shafar sel na adipose nama, yana hana fashewar kitse ya zama mai kitse.

Kwatanta halaye

Gudanar da bincike da nufin yin nazarin aikin insulin glargine, masana kimiyya sun yanke shawara cewa tasirin jikinta yayi kama da insulin na mutum. Gudun cikin jijiyar waɗannan abubuwa daidai gwargwado yana haifar da gaskiyar cewa abubuwan biyu suna da sakamako iri ɗaya akan metabolism metabolism. Kuma tsawon tasirinsu ga jikin mutum ya dogara ne da wasu dalilai, wadanda suka hada da aikin jiki.

Koyaya, an lura cewa glargine insulin, wanda aka saka a cikin mai mai yalwa, yayi aiki sosai a hankali fiye da insulin ɗan adam. Amma tsarin saki na hormone ya tafi daidai, wanda ya ba shi damar shafar jikin mutum na dogon lokaci, ba tare da haifar da canje-canje kwatsam a matakan glucose na jini ba.

Wadannan kyawawan halaye na insulin glargine an yi bayanin su ta hanyar jinkirin da ke cikin hankali, don mutane masu ciwon sukari suna buƙatar amfani da shi sau ɗaya a rana.

Matsakaicin tsawon insulin glargine shine sa'o'i 24. Koyaya, a cikin aikin likita akwai marasa lafiya waɗanda suke buƙatar yin amfani da wannan abun a cikin kowane sa'o'i 29.

Yin amfani da wannan magani, kamar kowane, ya kamata a fahimci cewa lokacin bayyanarsa ya dogara da halayen mutum na mutum da sauran dalilai da yawa.

Ga wanda insulin Lantus yake contraindicated

Wannan magani yana da kusan babu contraindications. Iyakar abin da aka ban banbanci kawai sune:

• hypersensitivity to ko dai insulin kanta ko ga abubuwanda suke hada magunguna,
• a karkashin shekaru 6.

Ya kamata a gudanar da aikin kula da mata masu juna biyu ne kawai karkashin tsauraran kulawar likita.

Zai yiwu sakamako masu illa

Mafi tasirin sakamako a cikin jiyya na glargine na insulin, kamar yadda yake tare da kowane magani na insulin, shine hypoglycemia. Yana tasowa idan aka lissafta yawan magungunan ba daidai ba.

Tunda glucose shine babban mai samar da makamashi ga dukkanin sel na jiki, gami da kwakwalwa, tare da raguwa sosai a cikin matakinsa cikin jini, tsarin jijiyoyin mutum yana shan wahala da farko. Wannan ya faru ne saboda gaskiyar cewa babu wani glycogen ajiyar ajiya a cikin kwakwalwa, wanda ke haifar da matsananciyar ƙwayar ƙwayoyin sel da haɓaka yanayin da ake kira neuroglycopenia.

Sakamakon sakamako na yau da kullun

Mafi sau da yawa, alamun lipohypertrophy ko lipodystrophy suna bayyana a wuraren allurar insulin. Ya bambanta da yanayin nan guda biyu, lipoatrophy yana haɓaka da wuya. Don guje wa waɗannan abubuwan mamaki, ya zama dole a gabatar da kowane allura mai zuwa a cikin sabon wuri a cikin sassan da aka yarda na jikin.

Abubuwan da suka shafi gida game da insulin na iya yin ci gaba. An bayyana su a cikin bayyanannu masu zuwa:

• cikin zafi a wurin allurar,
• a cikin ruwan fata a wuraren fata inda ake yin allurar mafi yawan lokuta,
• a cikin bayyanar huhu tare da itching,
• a cikin halayen kumburi a wuraren allura.

Koyaya, duk waɗannan bayyanannun, a matsayin mai mulkin, sun ɓace wani ɗan lokaci bayan fara amfani da insulin Lantus.

Rashin sakamako masu illa

Da wuya, ana iya ganin alamun bayyananni a cikin marasa lafiya:

• mummunan rashin lafiyan, wanda ke haifar da barazana ga lafiyar da rayuwar mai haƙuri,
• rage ƙarancin gani da rashin gani,
• kumburi.

Mai mummunar halayen ƙwayar cuta ana haifar dashi ta hanyar lalacewar ayyukan tsarin rigakafi. Wadannan yanayi na iya faruwa:

• anaphylactic shock,
• martanin fata fata
• angioedema,
• gazawar numfashi
• rage karfin jini da sauransu.

Rage ƙarancin gani da rauni na gani, a matsayinka na ɗan lokaci, kuma na ɗan lokaci ne kuma saboda ƙayyadadden tsarin sukari na jini da ke gudana daga asalin cutar hawan jini. Idan ba a kula da shi ba, wannan yanayin na iya haifar da asarar hangen nesa na ɗan lokaci.

Gabatar da insulin Lantus na iya haifar da keta daidaitaccen ruwan-gishiri, yana haifar da bayyanar edema. Koyaya, wannan bayyana ma ta ɗan lokaci ce.

Hakanan ba zai iya amsawa ga insulin Lantus ba, wanda aka bayyana a cikin samar da kwayoyin kariya ga miyagun ƙwayoyi. A wannan yanayin, halayen giciye na faruwa ne tsakanin insulin din da ke nunawa da kuma insulin da ake sarrafawa daga waje. Haka kuma, irin wannan yanayin na iya bayyana ba kawai akan Lantus ba, har ma akan duk wasu magunguna masu dauke da insulin.

Addamar da ƙwayoyin rigakafi na iya haifar da ci gaba da cututtukan cututtukan jini biyu da na hyperglycemia. Sabili da haka, marasa lafiya galibi suna buƙatar gyaran sashi na Lantus.

Sau da yawa wani sakamako masu illa

Insulin glargine na iya haifar da wasu sakamako masu illa waɗanda ke da saukin ganewa. Wadannan sun hada da:

• dysplasia - yanayin da a wannan yanayin aka bayyana a cikin murdiya dandano,
• myalgia - cuta ce da ke faruwa saboda haɓakar sautin ƙwayar tsoka.

Hanyar sarrafa insulin ta Lantus

Kafin amfani da insulin Lantus, umarnin yin amfani da shi yakamata a yi nazari da kyau. Ya kamata a tuna cewa wannan haramtaccen magani an hana shi allurar ciki, tunda yana iya tayar da haɓakar siffofin cututtukan zuciya.

Zaku iya yin allurar a cikin sassan jikin:

• zuwa bango na ciki,
• a cikin ƙwayar tsoka
• cikin cinya cinya.

Lokacin gudanar da bincike, babu wani bambanci mai tsayi tsakanin taro na insulin allura a cikin sassa daban-daban na jiki.

Magungunan insulin Lantus SoloStar yana samuwa a cikin hanyar da ake amfani da kicin tare da maganin insulin. Yana da amfani nan da nan. A wannan yanayin, bayan an gama maganin, dole ne a zubar da abin da ya dace.

Magungunan Insulin Lantus OptiKlik shine alkalami mai sike wanda ya dace don maimaitawa bayan maye gurbin tsohuwar kabad tare da sabon.

Siffofin amfani da insulin Lantus

Ya kamata a tuna cewa ba shi yiwuwa a gauraya maganin insulin ko a haɗa shi da wasu magunguna waɗanda ke kunshe da insulin, tunda a wannan yanayin za a lalata kalmar bayyanar da miyagun ƙwayoyi ga jikin mai haƙuri. Bugu da kari, idan aka haxa shi da wasu magunguna a cikin maganin Lantus, hazo na iya zama.

Don kiyaye ingantaccen taro na glucose a cikin jini, ya isa ya sarrafa magunguna sau ɗaya a rana a lokaci guda. Haka kuma, lokacin dayi bashi da mahimmanci.

Ya kamata yawan lissafin magungunan da lokacin gudanarwarsa ya kamata ya lissafta ta halartar likitocin daban daban akan kowane takamaiman mai haƙuri.

Ana iya gudanar da jiyya na rashin lafiyar insulin-da-insulinus din ta hanyar hadewar subcutaneous na insulin Lantus da magungunan antidiabetic na baka.

Ya kamata a tuna cewa a cikin mutane sama da shekaru 65 akwai raguwa a cikin aikin koda, wanda ke haifar da raguwa a cikin metabolism metabolism. Saboda haka, bukatun su na insulin ya ragu sosai.

Rage sashi na miyagun ƙwayoyi ana buƙatar marasa lafiya waɗanda ke fama da aikin hanta. A cikin irin waɗannan marasa lafiya, an toshe hanyoyin samuwar glucose daga ƙoshin da sunadarai, kuma tsarin insulin insulin yana raguwa sosai.

Daidaitawar sashi na maganin wanda ke dauke da sinadarin insulin glargine shima wajibi ne a wasu halaye. Wadannan sun hada da:

• canza haƙuri mai nauyi
• canjin rayuwa
• da bukatar canza lokacin gudanar da magani,
• idan tare da gabatarwar magunguna suna haifar da sakamako wanda zai iya haifar da haɓakar hypo- ko hyperglycemia.

Kafin amfani na farko, ya zama dole a hankali yin nazarin umarnin da mai sana'anta ya bayar na magani. Lallai ya kamata kuma bincika yanayin mafita: lallai ne ya zama bayyananne sarai ba tare da ƙazanta ba.

Ya kamata a tuna cewa an samar da wannan ƙwayar magani ta hanyar mafita, sabili da haka baya buƙatar ƙarin dilution da haɗuwa.

Abinda yakamata ayi idan akasamu yawan shan ruwa

Rashin ƙididdigar yawan magunguna ba daidai ba na iya haifar da haɓakar rashin ƙarfi na jini, magani wanda ya kamata a gudanar dashi a cikin tsakaitattun wurare. Tare da ingantaccen tsari na hypoglycemia, yawan shan carbohydrates mai sauƙi na iya taimakawa mai haƙuri.

A cikin mawuyacin hali, marasa lafiya na iya buƙatar saka allurar ta intramuscularly ko kuma maganin glucose wanda aka sarrafa a ciki.

Yin hulɗa tare da wasu kwayoyi

Wasu kwayoyi na iya shafar aiki na glucose ta hanyar insulin, wanda na iya buƙatar gyara ga tsarin kulawa da canje-canje a cikin tsarin insulin Lantus.

Shirye-shiryen magunguna masu zuwa na iya inganta tasirin insulin glargine:

• magungunan baka na baka:
• kwayoyi waɗanda ke da tasiri mai hana aiki kan ayyukan ACE,
• Disopyramide - wani magani ne wanda yake daidaita karfin zuciya,
• Fluoxetine - magani ne da aka yi amfani da shi a cikin nau'ikan nau'ikan rashin ƙarfi,
• shirye-shiryen da aka yi akan tushen fibroic acid,
• kwayoyi masu hana ayyukan monoamine oxidase,
• Pentoxifylline - magani ne na ƙungiyar angioprotectors,
• Propoxifene magani ne mai narkewa tare da tasirin maganin tashin hankali,
• salicylates da sulfonamides.

Wadannan kwayoyi suna iya raunana aikin insulin glargine:

• anti-mai kumburi kwayoyin da ke kashe tsarin garkuwar jiki,
• Danazol - magani ne na rukuni na analogs na androgens,
• Diazoxide
• diuretic kwayoyi
• shirye-shiryen da ke kunshe da analogues na estrogen da progesterone,
• shirye-shirye da aka yi akan tushen phenothiazine,
• kwayoyi wadanda suke haɓaka aikin norepinephrine,
• roba analogues na kwayoyin hodar iblis,
• shirye-shiryen da ke kunshe da bayanin halitta ko ta wucin gadi,
• magungunan ƙwayoyin cuta
• masu hana masu kariya.

Haka kuma akwai wasu magunguna waɗanda abubuwan da ba a iya tantancewa ba. Dukansu suna iya raunana tasirin insulin glargine da haɓaka shi. Wadannan kwayoyi sun hada da masu zuwa:

• B-masu hanawa
• wasu hanyoyin rage karfin jini
• salts na gishiri
• barasa

Tsayayyar rayuwa da kayan adana kayan ajiya

An ba da izinin amfani da miyagun ƙwayoyi Lantus insulin glargine ba fiye da shekaru 3 daga ranar saki ba. A wannan yanayin, kabad ɗin buɗewa ya dace don amfani don makonni 4. Don haka, ya kamata a nuna ranar budewar a kan tambarin ta.

Mafi kyawun yanayin zafin jiki na magani shine 2-8 ° C. Wannan yana nufin cewa kuna buƙatar adana insulin Lantus a cikin firiji. Koyaya, kafin amfani dashi, alkalami mai sirinji tare da kicin ɗin dole ne a kiyaye shi a zafin jiki a cikin 'yan awanni biyu.

Ba a yarda ya daskare maganin ba. Kuma bayan buɗe kicin, kuna buƙatar adana shi ba makwanni huɗu 4 a cikin wani wuri mai kariya daga hasken rana kai tsaye. Koyaya, bai kamata a sanya shi cikin firiji ba.

Me ake nema?

Lokacin amfani da miyagun ƙwayoyi, kuna buƙatar yin hankali a cikin aikin da ke buƙatar hankali da daidaito. Dangane da haɓaka yanayin haɓaka, mai haƙuri na iya shafar ƙimar amsawa da ikon maida hankali.

Hakanan ya kamata a yi taka tsantsan don masu ciwon sukari tare da nakasa da hanta da aikin koda. Abubuwan da ke dauke da kwayar insulin suna shafar hanta - suna rage ƙimar samar da glucose.

Tare da gazawar hanta, ana amfani da glucose sosai a hankali kuma ba tare da sakamako na musamman ba. A ƙarƙashin rinjayar Lantus, raunin sukari na iya faruwa, wanda ke da haɗari ga mutane. Sabili da haka, yana da kyawawa ga irin waɗannan marasa lafiya don rage yawan insulin, suna mai da hankali ga tsananin cutar.

Kodan suna cikin raha cikin nutsuwa na kayan aiki da kayan abinci. Idan sun lalace kuma basa aiki yadda yakamata, to ya fi musu wahala su cire adadin insulin daidai. Sakamakon ƙarancin narkewar ƙwayar cuta, abu yana tarawa a cikin jiki, yana rage girman sukari, wanda ke da haɗari ta hanyar haɓaka halin haɓaka.

Yadda ake shiga?

An bambanta wannan magani ta tsawon lokacin bayyanar, sabili da haka, ya fi dacewa a zaɓi shi fiye da, alal misali, sauran analogues na Lantus insulin. An wajabta shi ga marasa lafiya da ke fama da ciwon sukari da ke cikin insulin, kuma wannan ba shine kawai cutar farko ba.

Analogs ɗin da aka fi sani da suke maye gurbin insulin Lantus sune -, Humalog, da Apidra.

Lantus, kamar wasu analogues na wannan insulin, ana gudanar dashi ta allurar subcutaneous. Ba'a yi nufin sarrafawar ciki ba. Abin lura shine, lokacin lura da wannan maganin an lura da shi ne kawai lokacin da aka gabatar dashi cikin kitse mai karkashin ciki.

Idan kun yi watsi da wannan ƙa'idar kuma ku gabatar dashi cikin jijiyoyin wuya, zaku iya tsokanar abin da ya faru na rashin ƙarfi a cikin jini. Dole ne a gabatar dashi cikin kitse na ciki, kafadu ko gindi.

Yana da mahimmanci kada ku manta cewa baza ku iya yin allurar insulin a wuri guda ba, tunda wannan ya cika ne tare da samuwar hematomas.

Lantus na analogues, kamar kansa, ba dakatarwa bane, amma shine mafita gaba daya.

Yana da mahimmanci a nemi shawara tare da likitan ku game da amfani da ba magungunan kanta ba, amma sanannun analogues, waɗanda ke da tasirin iri ɗaya.

Ana fara aikin Lantus da wasu maganganu na analogues daidai sa'a daya daga baya, kuma matsakaicin tsawon tasirin yana kusan kwana ɗaya. Amma, wani lokacin yana iya samun sakamako mai ɗorewa na sa'o'i ashirin da tara, gwargwadon sashin da aka sarrafa - wannan yana ba ku damar mantawa game da injections na duk ranar.

Don kawar da mummunan alamun bayyanar cutar sankara, ƙwararrun likitoci sun tsara magungunan Lantus da shahararrun magungunan analogues. A cikin dogon lokaci, irin waɗannan magungunan sun sami sannu a hankali kuma a yanzu ana ɗaukar su lamba ɗaya a cikin yaƙi da wannan cin zarafin tsarin endocrine.

Yawancin fa'idodi na maganin wucin gadi na wucin gadi:

1. yana da tasiri sosai kuma yana iya rage alamun bayyanar cutar sankara,
2. yana da ingantaccen bayanin martaba,
3. mai sauki don amfani
4. zaka iya aiki tare da injections na miyagun ƙwayoyi tare da rufin asirin kansa.

Analogs na wannan magani yana canza lokacin bayyanar kwayar halittar mutum don samar da hanyar mutum game da magani da mafi girman kwanciyar hankali ga mai haƙuri da ke fama da rikicewar endocrine.

Wadannan magunguna suna taimakawa ga cimma daidaituwa tsakanin hadarin saukar da sukari na jini da kuma cimma nasarar glycemic matakin.

A halin yanzu, akwai da yawa daga cikin hanyoyin gama-gari da ake amfani da su na hormone na mutum:

• ultrashort (Humalog, Apidra, Novorapid Penfill),
• tsawanta (Lantus, Levemir Penfill).

Tsawancin magungunan Lantus Solostar analogues, bi da bi, kuma yana da - Tresiba an dauke shi ɗayan shahararrun.

Lantus ko Tresiba: Wanne ya fi kyau?

Don farawa, ya kamata kuyi la'akari da kowannensu daban-daban. Abubuwan da ke aiki da ƙwayar da ake kira Tresiba shine insulin degludec. Kamar Lantus, kwatanci ne na hormone na mutum. Godiya ga aiki mai zafi na masana kimiyya, wannan magani ya sami kayan kirki daban-daban.

Don ƙirƙirar sa, an yi amfani da ƙwararrun ilimin halittar ɗan adam na DNA tare da haɗin gwiwar ƙwayar Saccharomyces cerevisiae, kuma an daidaita tsarin kwayoyin insulin na mutum.

A yanzu, ana iya amfani da wannan magani ga marassa lafiya, iri na biyu da na biyu. Yana da mahimmanci a lura cewa yana da wasu fa'ida idan aka kwatanta da sauran analogues na insulin, wanda a yanzu akwai adadi da yawa.

Dangane da alkawuran masana'antun, babu hypoglycemia da ya kamata ya faru lokacin amfani da miyagun ƙwayoyi Tresib. Akwai wani amfani ga miyagun ƙwayoyi: ƙarancin canji a matakin glycemia yayin rana. A takaice dai, yayin maganin warkewa ta amfani da magungunan Treciba, ana kiyaye yawan sukarin jini na awanni ashirin da huɗu.

Wannan fa'idodi ne mai mahimmanci, tunda amfanin wannan analog na Lantus yana ba ku damar yin tunani game da insulin ba kawai da rana ba, har ma da dare.

Amma wannan kayan aiki yana da mahimmancin ɓarkewa: ba a ba da shawarar amfani da shi ba ga mutane underan shekaru goma sha takwas, masu ciki da masu shayarwa. Hakanan baza'a iya yinsa ta allura ta ciki. Ana amfani da subcutaneous amfani kawai.

Amma ga Lantus, duk fa'idodin nasa an yi bayanin su a sama. Amma idan muka zana daidaituwa tsakanin waɗannan maye gurbin insulin, zamu iya yanke hukunci cewa matakin glycated hemoglobin yana raguwa zuwa mafi girman amfani da maganin Tresib fiye da na Lantus.Abin da ya sa analogues na ƙarshen suna da inganci sosai.

Tun da, rashin alheri ne, an dakatar da Lantus, an fi so ga marasa lafiya na endocrinologists waɗanda ke fama da nau'ikan cututtukan cututtukan guda biyu don ɗaukar madadin insulin da ake kira Tresiba.

Bidiyo masu alaƙa

Wanda ya ƙera Lantus baya cikin ƙasa ɗaya, amma biyu - Jamus da Rasha. Ana iya siyanta a wasu kantin magunguna, amma ba da jimawa ba analologues ko sigar aiki da kanta ana yawan amfani dashi. Wannan saboda magani kwanan nan yana da matukar wahala a samu. A cikin Lantus, girke-girke na Latin yawanci yana kama da wannan: “Lantus 100 ME / ml - 10 ml”.

Jiyya mai zurfi ta amfani da wannan magani na iya inganta ingantacciyar rayuwa da sarrafa glycemia a cikin mutane iri biyu masu ciwon sukari. Yana da mahimmanci a kusanci liyafar don kar wata illa. Tabbatar ka bi sashi wanda likita ya umarta don hana nau'ikan rikitarwa da sakamakon amfani.

Lantus magani ne da ake amfani da shi don magance ciwon sukari.