9 inganci da araha analogues na Rosuvastatin

Ana gabatar da Analogues na miyagun ƙwayoyi Krestor, daidai da ƙararren likita, wanda ake kira "daidaitawa" - magunguna masu canzawa waɗanda ke ɗauke da ɗaya ko fiye na abubuwa guda masu aiki dangane da tasirin su akan jiki. Lokacin zabar kalmomin kama da juna, yi la'akari da farashin su ba kawai, har ma da ƙasar da aka ƙera da martabar mai ƙira.

Bayanin maganin

Rosuvastatin mai hanawa ne, mai haɓaka mai hanawa na HMG-CoA reductase, enzyme wanda ke canza 3-hydroxy-3-methylglutaryl coenzyme A zuwa mevalonic acid, ƙwayar cholesterol. Babban maƙasudin aikin rosuvastatin shine hanta, inda ake aiwatar da kwayar cholesterol (cholesterol) da kuma catabolism of low yawa lipoproteins (LDL).

Rosuvastatin yana kara adadin masu karɓa na “hepatic” LDL akan farfajiyar tantanin halitta, da haɓaka haɓakawa da haɓakar LDL, wanda hakan yana haifar da hanawar ƙirar lipoproteins da yawa (VLDL), ta haka ya rage adadin LDL da VLDL.

Krestor wers lowers girman tasoshin LDL cholesterol (cholesterol-LDL), jimlar cholesterol, triglycerides (TG), yana ƙaruwa da haɓakar ƙwayoyin lipoprotein mai ƙarfi (HDL-C), kuma yana rage taro na apolipoprotein B (ApoV), non-HDL -LVONP, TG-VLDLP kuma yana kara yawan kwantar da hankali na apolipoprotein AI (ApoA-I) (duba tebur 1 da 2), rage yawan rabo daga LDL-C / HDL-HDL, jimlar cholesterol / HDL-C da HDL-C / HDL-C da ApoB / ApoA-1 rabo.

Tasirin warkewa yana tasowa a cikin sati guda bayan fara fargaba tare da Krestor ®, bayan makonni 2 na magani ya kai 90% na iyakar tasirin sakamako. Matsakaicin tasirin warkewa shine mafi yawa ana samun shi ta mako na 4 na farji kuma an kiyaye shi tare da amfani da magani na yau da kullun.

Tebur 1 da 1a.Sakamakon-kashi-dogara a cikin marasa lafiya da keɓaɓɓen hypercholesterolemia (nau'in IIa da IIb a cewar Fredrickson) (matsakaiciyar daidaitawa sauyin da aka daidaita idan aka kwatanta da ƙimar asali).

Krestor ® yana da tasiri a cikin tsofaffi na marasa lafiya tare da hypercholesterolemia tare da ko ba tare da hypertriglyceridemia ba, ba tare da la'akari da launin fata, jinsi ko shekaru, incl. a cikin marasa lafiya da ciwon sukari mellitus da familial hypercholesterolemia.

A cikin 80% na marasa lafiya da ke dauke da nau'in IIa da IIb hypercholesterolemia bisa ga Fredrickson (matsakaiciyar farkon farawa na LDL cholesterol shine kimanin 4.8 mmol / L) yayin ɗaukar ƙwayar a kashi 10 mg, yawan ƙwayoyin LDL cholesterol ya kai dabi'u ƙasa da 3 mmol / L.

A cikin marasa lafiya tare da hypertriglyceridemia tare da maida hankali na farko na TG daga 273 zuwa 817 mg / dl waɗanda suka karɓi Krestor ® a cikin kashi 5 MG zuwa 40 MG sau ɗaya a rana don makonni 6, an rage yawan taro na TG a cikin jini na jini (duba tebur 2).

Ana lura da sakamako mai ƙari a hade tare da fenofibrate dangane da taro na triglycerides kuma tare da nicotinic acid a cikin rage ƙarancin lipid dangane da haɗuwa da HDL-C.

A cikin binciken METEOR, wanda ya shafi marasa lafiya 984 masu shekaru 45-70 shekaru tare da ƙarancin haɗarin haɓaka cututtukan zuciya na zuciya (haɗarin 10 a kan ma'aunin Framingham ƙasa da 10%), matsakaicin taro na LDL cholesterol na 4.0 mmol / l (154.5 mg / dl) da ƙananan ƙwayoyin atherosclerosis ( wanda aka kimanta da kauri daga cikin hadaddun kafofin watsa labarai na intro-carotid arteries - TCIM) sakamakon binciken rosuvastatin akan kauri daga cikin hadaddun kafofin watsa labarun. Marasa lafiya sun karɓi rosuvastatin a kashi 40 MG / rana ko placebo har tsawon shekaru 2.Rashin maganin Rosuvastatin ya rage raguwar ci gaba na matsakaicin TCIM don kashi 12 na ƙwayar carotid idan aka kwatanta da placebo tare da bambancin -0.0145 mm / shekara. Idan aka kwatanta da ƙimar farko a cikin rukunin rosuvastatin, an rage raguwa a cikin matsakaicin darajar TCIM ta 0.0014 mm / shekara (0.12% / shekara (ƙarancin bambanci)) idan aka kwatanta da haɓakar wannan mai nuna ta 0.0131 mm / shekara (1.12% / shekara (p 1/100 , 1/1000, 1/10000, Labarai masu alaƙa

A mafi yawan lokuta, rashin lafiya ta kan sami mutum idan bai shirya haduwa da su ba. Cututtukan hoto ko bidiyo guda biyu sune cututtukan cututtukan yau da kullun. Tare da su, cututtuka sau da yawa suna faruwa wanda ke shafar tsarin numfashi. A.

Magunguna na zahiri sun ceci ɗan Adam a lokacin farko. Girke-girke na zahiri na mutanen zamani ba su rasa dacewar su ba. Kulawa da cututtukan ulcerative tare da magunguna na mutane sun bambanta a cikin hanyar haɗin kai. Ta hanyar ilimin halitta.

Hanci mai gudu a cikin kuliyoyi na iya haifar da dalilai iri daban-daban. Mafi yawan lokuta, fitar daga hancin dabba yana bayyana saboda mura guda. Wani lokacin rhinitis shine sakamakon rashin lafiyan ƙwayar cuta ko ma wani mummunar cuta mai kamuwa da cuta.

Tsarin kwayoyin

Abubuwan da ke aiki da miyagun ƙwayoyi shine gishirin alli na rosuvastatin. Bugu da ƙari, abun da ke ciki ya haɗa da ƙarin ƙarin kayan aikin, kowane ɗayan yana taka rawar:

1. Microcrystalline cellulose shine mai talla mai kyau wanda aka yanke shi wanda bai canza daga jikin mutum ba. A cikin abubuwan da ke cikin miyagun ƙwayoyi, yana aiki a matsayin filler da kayan da ke ba da haɗin ga abubuwan haɗin duka.
2. Lactose Monohydrate. Anyi amfani dashi don inganta dandano na miyagun ƙwayoyi. Koyaya, wannan abun yana haifar da rashin ɗaukar allunan ga mutanen da ke fama da rashin haƙuri ko ƙarancin lactase.
3. Farin Calcium Wannan wani hadadden fili ne, wanda ya hada da karafan ƙarfe da kuma phosphoric acid. Abubuwan da ke tattare da Allunan suna taimaka wa ɗan aiki babban abu.
4. Magnesium stearate. Fitar da kwamfutar hannu tsari da kuma aiki a matsayin filler mai lafiya ga jiki.
5. Hydroxypropyl methylcellulose wani kayan maye ne na musamman wanda yake da mahimmanci ga tsarin masana'antu na nau'in sashi.
6. Povidone yana aiki azaman sihirin da ke magance abubuwa masu guba ga jiki, gami da abubuwanda aka kirkira sakamakon aikin rosuvastatin.
7. Triacetin shine ingantaccen kayan abinci (E1518). A matsayin ɓangare na allunan, yana aiki azaman plasticizer da daskararru, wanda yake da mahimmanci don aiwatarwa.
8. Dyes - baƙin ƙarfe da iron dioxide sune abubuwan haɗari masu aminci don haɓaka bayyanar da miyagun ƙwayoyi.

Allunan magungunan Rosuvatatin, wadanda aka yi amfani dasu ga cholesterol sama da na yau da kullun, kamfanoni masu magunguna suna samarwa a ƙarƙashin sunaye daban-daban. Dukkanin su analogues ne na kai tsaye, wato, suna da abu guda na aiki.

Krestor na asali yana samar da kamfanin Ingilishi kuma yana da suna a matsayin magani mafi inganci. Duk sauran magunguna inda kayan aiki masu aiki shine rosuvastatin sune kwayoyin.

Sun bambanta da na asali cikin farashi kuma na iya samun ɗan kayan dabam dabam na kayan taimako, wanda baya tasiri tasirirsu. Ya kamata a yi la’akari da wannan batun tare da ƙara azanci ga wasu abubuwa.

Aikin magunguna

Magungunan ƙwayar cuta shine zaɓi mai haɓaka, mai haɓakar hanawar HMG-CoA, enzyme wanda ke canza 3-hydroxy-3-methylglutaryl coenzyme A zuwa mevalonate, mai hana cholesterol (Xc). Babban maƙasudin aikin rosuvastatin shine hanta, inda ake aiwatar da sinadaran Xc da LDL catabolism.

Tasirin warkewa yana bayyana a cikin mako 1 bayan farawar Krestor far, bayan makonni 2 na magani ya kai 90% na iyakar tasirin sakamako. Mafi girman tasirin warkewa ana samunshi da makonni huɗu kuma ana kiyaye shi tare da amfani na yau da kullun.

Kusan 90% na kashi na rosuvastatin an cire shi da feces. Ragowar yana cikin fitsari.

Analogues na miyagun ƙwayoyi

Analogs suna da rahusa fiye da na asali, kuma mai haƙuri na iya maye gurbin magani ɗaya tare da wani, yana mai da hankali ga rashin damar ko wadatar maganin a cikin kantin magani. Sun bambanta da ɗan inganci, wanda ke da alaƙa da ingancin kayan aikin da aka yi amfani da su da kuma wasu bambance-bambance a cikin aiwatarwa. Analogs a cikin abin da abu mai aiki shine rosuvastatin:

1. Kanta Magungunan asali da aka yi a Burtaniya. Yana da babban bioavailability, yana da tasirin warkewa da sauri tare da cholesterol sama da al'ada. Yana da farashi mai girma idan aka kwatanta shi da ƙwayoyin cuta.
2. Akorta, Rosuvastatin Canon da Rosuvastatin SZ suna samar da masana'antar Rasha. Suna cikin rukuni na analogues mai araha. Amma suna da ƙananan bioavailability, mafi sannu a hankali ƙirƙirar taro a cikin jiki ya zama dole don cimma sakamako mafi girma. An cire shi da sauri daga jiki.
3. Mertenil. Mai masana'anta - Hungary. Hakanan yana da ƙarancin digirin bioavailability, don haka tasirin warkewa yana faruwa daga baya fiye da maganin asali.
4. Rosulip wani magani ne daga masana'antun 'yan ƙasar Hungary. Ba shi da tsada mai tsada. An rarrabe shi ta hanyar babban bioavailability, amma a lokaci guda, yana tara hankali a hankali, ƙirƙirar maida hankali ga warkewa.
5. Kamfanin kamfanin Icelandic ne ya samar da Rosart. Yana da duk fa'idodin magani na asali, rashin jin daɗinsa sun haɗa da babban farashi.
6. Harshen Ros Ctionirƙirar ƙasar Croatia. Ba shi da ƙasa da Rosart ko Krestor ta kowace hanya, a lokaci guda kuma yana da mafi tsada sosai.
7. Tevastor Kamfanin kera magunguna na Isra’ila ne ya kera shi, cikin sauri ya tara jiki kuma yana da tasirin warkewa. Yana da babban farashi.
8. Roxer an samar dashi ta sanannun kamfanin Slovenian. Yana da farashin matsakaici, ingantaccen bioavailability, amma an cire shi da sauri daga jiki sabili da haka a hankali yana da sakamako na warkewa.
9. Rosucard shiri ne na Czech. A wani matsakaici tsada, yana da babban bioavailability, amma mara ƙarancin farawa na aikin warkewa.

Duk waɗannan magunguna suna analogs kai tsaye, i.e., tare da abu guda mai aiki kuma ana daidaita su. A aikace, kayan aiki ɗaya ne, iri ɗaya ne, wanda ke da sunaye na kasuwanci daban-daban kuma ana sayar da shi a farashin daban. Akwai alamun adalai.

Irin waɗannan kwayoyi suna da sakamako guda ɗaya (a wannan yanayin, rage yawan lipid), amma suna da bangarori daban-daban masu aiki. Sauyawa don irin waɗannan analogues na likita ne kawai zasu iya yin shi.

Pharmacokinetics a cikin lokuta na musamman na asibiti

Jinsi da tsufa ba su da tasiri mai mahimmanci a asibiti kan magunguna na rosuvastatin.

A cikin marasa lafiya tare da gazawar ƙarancin ƙayyadadden matsakaici zuwa matsakaici, ƙwayar plasma ta rosuvastatin ko N-dysmethyl ba ta canza sosai.

A cikin marasa lafiya da mummunan gazawar renal (CC 1/100, 1/1000, 1/10 000,

9 inganci da araha analogues na Rosuvastatin

• Tsarin kwayoyin
• Analogues na miyagun ƙwayoyi

An tsara Rosuvastatin da analogues ɗin don cholesterol a cikin jini sama da al'ada. Magungunan yana cikin rukunan gumaka na ƙarshe (ƙarni 4). Idan aka kwatanta da sauran kwayoyi a cikin wannan rukunin, rosuvastatin wata hanya ce mafi inganci da aminci.

An kirkiro shi da kishi kuma yana nuna kaddarorin hydrophilic, a sakamakon hakan bashi da tasirin sakamako akan hanta.

Magungunan suna hana samar da wadataccen lipoproteins masu ƙarancin ƙarfi, waɗanda sune babban abin da ake samar da sinadarin cholesterol.

Bugu da kari, shan wannan magani ba ya haifar da rikicewar tsoka da sauran cututtukan jiki daga gefen ƙwayar tsoka. Sakamakon da ya dace yana bayyana tuni mako guda bayan fara amfani da shi, kuma har zuwa makonni 4 ya zama mafi yawa kuma tare da kulawa na yau da kullun yana ɗaukar tsawon lokaci. Wadannan halayen suna sa rosuvastatin ta zama magani mai matukar bukatar marasa lafiya da ke buƙatar rage ƙwayar cholesterol.

Crestor: umarnin don amfani, analogues, farashi da bita

1. Abun ciki da sashi tsari
2. Hanyar magunguna
3. Pharmacodynamics
4. Pharmacokinetics
5. Wanda aka Nuna Crestor
6. Yadda ake nema
7. Side effects
8. Abun hani na aikace-aikace
9. Yarda da wasu magunguna
10. Crestor: analogues
11. Me likitoci da marasa lafiya suke tunani game da Crestor

Masu karatun mu sunyi nasarar amfani da Aterol don rage cholesterol. Ganin shahararrun kayan wannan samfurin, mun yanke shawarar ba da shi ga hankalin ku.

Kuna iya jin daɗi a cikin yanayin rayuwar ku na yau da kullun, kuma bayan gwaji, koya game da hyperlipidemia - karuwar abun ciki na cholesterol da triglycerides a cikin jini. Cutar asymptomatic tana ƙara haɗarin haɗarin filayen atherosclerotic - abubuwanda ke haifar da bugun zuciya da bugun jini.

Krestor, ingantaccen magani na ƙarshe wanda aka tsara don daidaita al'ada metabolism, zai taimaka hana haɗari mai haɗari.

Abun ciki da sashi tsari

Ana sayar da gicciye a cikin nau'ikan allunan. Dangane da maida hankali ne ga kayan aiki mai aiki, ana samar da nau'ikan magunguna masu yawa:

1. Wadanda aka yiwa alama mai launin rawaya da kuma zane tare da ZD4522 5 sune convex, zagaye, dauke da 5 g of rosuvastatin.
2. Kwayoyin ruwan hoda mai launi iri ɗaya wanda aka zana shi da ZD4522 10 ya ƙunshi 10 mg na abu mai aiki.
3. A cikin irin kwamfutar hannu iri ɗaya tare da rubutun ZD4522 20 - rosuvastatin 20g.
4. Matsakaicin mafi girman abu mai aiki (49 mg) yana cikin allunan ruwan hoda mai alama tare da alamar ZD4522.

Duk nau'ikan magani (gami da magungunan analogues) an tsara su sosai

Pharmacodynamics

Krestor yana hana HMG-CoA reductase, enzyme wanda ke kula da samar da mevalonate, ƙwayar cholesterol. Rosuvastatin yana aiki a cikin hanta - ɗayan manyan gabobin ƙwaƙwalwa.

Statin yana rage adadin lipoproteins tare da ƙarancin girma da ƙima ta hanayar haɗin aikin su, tare da haɓaka ƙarin HDL don haɓaka da catabolism na LDL. Sakamakon haka, matakin adadin kuzarin, LDL da triglycerides ya ragu. A lokaci guda, maida hankali ne akan HDL.

Rosuvastatin yana da tasiri ga hypercholesterolemia a hade tare ko ba tare da hypertriglyceridemia ba, don marasa lafiya na kowane jinsi, shekaru da tsere.

Sakamakon amfani da Krestor, yin hukunci ta hanyar martani daga mahalarta bincike, ana lura da shi a ƙarshen makon farko na hanya, amma ana iya ganin sakamako mafi girma (sama da 90%) kawai bayan makonni 2-4 na amfani na yau da kullun.

Ba kamar wasu analogues ba, Krestor yana da ƙananan tasirin mummunan sakamako akan hanta. Amfani dashi a hade tare da karancin abincin cholesterol da sauran magunguna wadanda ke rage cholesterol.

Wanda aka Nuna Crestor

Lokacin sauya Krestor tare da analogues, ya zama dole a fayyace a ƙarƙashin wane yanayi ake amfani dasu.

Asalin magani da aka nuna:

• Tare da hypercholesterolemia (na farko ko na dangi homozygous form),
• Don rigakafin bugun jini,
• Tare da hadewar hypercholesterolemia,
• Don rigakafin cutar zuciya,
• Mutane da atherosclerosis,
• Tare da hauhawar jini.

Yadda ake nema

Jigilar magani da sashi na likita ne suka yi shi bisa gwaji, yanayin lafiya, cututtukan da suka dace.

Dokokin ƙa'idoji don amfanin Crestor:

• Kwamfutar hannu ba ta buƙatar murƙushewa.
• Lokacin Amincewa - kowane dacewa, ana iya samun sakamako mafi yawa daga amfani da maraice, tunda yawancin samfuran cholesterol ana samarwa da dare.
• Abinci baya shafar tasirin magani.
• Kafin fara karatun, mai haƙuri ya kamata ya canza zuwa ƙaramar rage ƙwayar cholesterol, wanda dole ne a lura da shi koyaushe.
• An zaɓi kashi na farko na Crestor (5-10g / day) daban-daban. Idan sakamakon bai dace da tsammanin ba, zaku iya daidaita sashi zuwa 20 MG / rana, amma ba a farkon wata guda ba. An ƙayyade mafi girman ƙa'idar (40 mg / rana) kawai a babban haɗarin haɓakar jijiyoyin bugun zuciya da cututtukan zuciya. Marasa lafiya tare da matsanancin rashin ƙarfi na hypercholesterolemia ya kamata ya kasance a ƙarƙashin kulawa na likita koyaushe, tun da yiwuwar tasirin sakamako masu illa. Dole ne a kula da bayanan bayanan lipid don gyara tafarkin tilas a kowane mako 2-4.

Game da yawan abin sama da ya kamata, ba a amfani da takamaiman maganin rigakafi. Jiyya alama ce, ta la'akari da matsayin guba. Idan ya cancanta, ɗauki matakan tallafi.

Side effects

Tare da yin taka tsantsan da shawarwarin da likitocin da ke halartar suka tsara, marasa lafiya da wuya su koka da sakamakon da ba a zata ba daga amfani da Krestor. Duk da haka, umarnin don amfani yayi kashedin game da yiwuwar halayen da ba'a so. Bayanai sun dogara da karatun asibiti.

Dukkanin magungunan da ke sama sune analog na kai tsaye na rosuvastatin, wato, magunguna tare da abu mai aiki iri ɗaya. A zahiri, wannan duka - magani ɗaya ne da sunaye daban-daban na kasuwanci kuma ana sayar da shi a sikeli daban-daban da farashin dillali (za a ba da farashin matsakaita a cikin tebur a sashe na gaba na littafin). Har ila yau, akwai analogues na kaikaice, wato, kwayoyi daga rukunin masana'antar magani guda ɗaya (a wannan yanayin, ƙananan hana hana aiki), waɗanda ke da tasirin irin wannan, amma suna da bambancin aiki. Wadannan magungunan suna analogues ne kaikaice kuma ana iya ba da izini ta musamman ta halartar ƙwararrun kan bayanan dakin gwaje-gwaje.

Tebur kwatancen na farashin analogues na "Rosuvastatin"

Don ma'anar binciken, wanda aka gudanar kawai don amfanin masu amfani da magungunan da ake tambaya, jerin abubuwan da ke sama sun ƙunshi analogues a cikin sashi mai zuwa da yawa: 10 MG na rosuvastatin kowace kwamfutar hannu, Allunan 30 a cikin fakitin guda. Wannan nau'in aiwatarwa shine mafi mashahuri a tsakanin masu cin abinci, tun da yake yana da kyau a fara sarrafa magani a cikin wata-wata domin sanin ƙimar daidaitawar jikin mutum zuwa rosuvastatin.

Kudin "Rosuvastatin" da yuwuwar sauya shi da analogues

A cikin sarkar kantin sayar da kayayyaki "Rosuvastatin" a cikin sashi na 10 MG da yawan allunan, ana sayar da guda 30 a cikin tsadar farashi daga 380 zuwa 490 rubles, gwargwadon farashin farashi na mai siye da siyar da magunguna, kamar yadda ya dogara da yankin. Don haka, a mafi yawan lokuta, wakilin Rosuvastatin na asali yana da rahusa fiye da analogues, kuma yana da kyau a sayi analogues kawai idan ba a samo magungunan asali ba a wannan kantin magani. Dangane da sake dubawa da aka sanya a cikin hanyar jama'a a yanar gizo da kuma kafofin watsa labaru, ana kuma iya yanke shawara cewa masu cin kasuwa sun fi son ainihin maganin.

Ka'idodin maganin

Maganin magungunan Krestor shine cewa yana gabatar da enzyme na musamman wanda ke sarrafa samar da ƙwayoyin cholesterol ko mevalonate.

Abubuwan da ke aiki na miyagun ƙwayoyi suna aiki kai tsaye a cikin hanta, wanda ke samar da cholesterol.Wannan enzyme yana taimakawa rage yawan lipoproteins mai yawa, wanda ke taimakawa rage yawan sinadarin cholesterol a jiki, da kuma triglycerides.

Bugu da kari, kwalastin mai yawa yana tashi. Magungunan yana da tasiri ga marasa lafiya na kowane zamani, jinsi da launin fata. Yawancin sake dubawa na masu amfani sun ba da shawarar cewa sakamakon amfani da Krestor ya bayyana a farkon makon farko na hanya, yayin da an sami mafi girman inganci bayan kammala karatun a cikin makonni 2-4 na amfani da kullun.

Gicciye, ba kamar yadda aka yi amfani da ita analogues ba, yana da ɗan lahanin tasiri akan hanta ɗan adam. Zai fi kyau a haɗu da yin amfani da shi tare da abinci na musamman, da sauran magunguna waɗanda ke nufin rage ƙwayar cholesterol.

Abubuwan da ke cikin magani na magunguna sune kamar haka:

1. A cikin digiri na sha. Matsakaicin adadin statin yana bayyana a cikin jini bayan 5 hours, bayan amfani da miyagun ƙwayoyi.
2. A rarraba a cikin jiki. Babban yanki na aikin Krestor shine hanta, wanda ke samar da cholesterol. Yawan rarraba shine lita 134.
3. A cikin matakin metabolism. Ga Krestor, kusan 10% ne.
4. A cikin hanyar isar da sako. Adadin magungunan da ake keɓewa daga jiki shine kusan 90% a cikin sa'o'i 19 na gudanarwa.

Shekarun mai haƙuri, da jinsi, ba su da tasiri sosai a kan ƙirar magunguna.

Ya kamata ku kula da kasancewar cutar koda. Don haka, daidaitaccen matsakaici da matsakaici na lalacewa na ƙirar a zahiri ba ya shafar matakin statin, yayin da a cikin nau'i mai tsanani, yawan rosuvastatin yana ƙaruwa sau 3.

Kasancewar cututtukan hanta a zahiri ba su shafar amfani da miyagun ƙwayoyi.

Krestor - analogues na miyagun ƙwayoyi da alamomi don amfani

Duk wata magana mai rahusa ko sauƙin magani, idan mai haƙuri ya yanke shawarar amfani da shi, yana buƙatar tsarin kulawa da hankali.

A takaice dai, marasa lafiya waɗanda suka yanke shawarar maye gurbin magunguna na asali tare da wani ƙwayar cuta ya kamata ko dai su shawarci likitan su, ko kuma su san abin da ke nuna alamun amfani a cikin umarnin su.

Da farko, Krestor ya bada shawarar amfani da:

• tare da hypercholesterolemia,
• a matsayin rigakafin bugun zuciya da bugun zuciya,
• tare da gauraye hypercholesterolemia,
• mutane tare da atherosclerosis,

Bugu da ƙari, an bada shawarar yin amfani da miyagun ƙwayoyi a gaban hypertriglyceridemia.

Umarnin don amfani da miyagun ƙwayoyi

Krestor, kamar kowane magani, yana da tsari da sashi na amfani.

A matsayinka na mai mulki, likitan ne ya kayyade yawan maganin da ya kamata mai haƙuri ya yi amfani da shi. Yana yin wannan ne bisa tushen binciken da sakamakon bincike.

Bugu da kari, yanayin yanayin mai haƙuri da kasancewar cututtukan haɗin gwiwa ana la'akari dasu.

Saboda haka, ya kamata a dauki Krestor kamar haka:

1. Kara a kwamfutar hannu da miyagun ƙwayoyi.
2. Lokaci mafi dacewa don ƙaddamarwa ana ɗauka ya zama maraice dangane da haɓaka matakin ƙwayar cholesterol a cikin jiki.
3. Cin abinci baya shafar tasirin magungunan da aka sha.
4. Kafin ɗaukar hanyar magani, ana bada shawarar mai haƙuri ya bi tsarin rage cin abinci a cikin cholesterol.
5. Da farko, wajibi ne a sha maganin a cikin adadin 5-10 g kowace rana. Koyaya, an zabi sashi na maganin ta musamman daban kuma ta likita. Idan babu sakamakon sigar da aka ɗauka, ana iya ƙaruwa zuwa milligram 20, amma bayan wata ɗaya. Matsakaicin adadin 40 milligrams an wajabta shi kawai a cikin lokuta inda haɗarin haɓakar cuta na zuciya yana da matukar girma. Marasa lafiya tare da matsanancin hypercholesterolemia ya kamata su kasance a ƙarƙashin kulawa na likita koyaushe don guje wa sakamako masu illa.

Idan mai haƙuri yana da maganin wuce haddi na miyagun ƙwayoyi, maimakon amfani da kowane maganin rigakafi, ana amfani da matakan tallafi.

Babban analogues na Crestor

A cikin kasuwar zamani don magunguna, an gabatar da adadin magunguna masu yawa. Koyaya, a matsayinka na doka, magunguna na asali suna da tsada sosai kuma ba kowane mai haƙuri yana da damar siye su ba.

A wannan batun, yawancin masana'antun sun yanke shawarar maye gurbin asalin tare da analogues. A matsayinka na mai mulkin, babban bambanci tsakanin waɗannan kwayoyi shine farashin.

Bugu da ƙari, yana da kyau a la'akari da cewa duk wani ƙwayar magani ko analog ɗin sa ya kamata likita ya tsara shi wanda zaiyi la'akari da duk abubuwan da ke tattare da cutar da matsayin lafiyar haƙuri.

Daga cikin mashahuran analogues sune:

1. Akorta. Abokin Rasha. Daidai ne a cikin kayan, kuma a alamace don amfani. Ana amfani dashi na dogon lokaci kamar yadda aka tsara.
2. Mertenil. Babban sinadaran aiki shine rosuvastatin. Cikakken analog ne na ƙasan waje wanda ya zo daidai cikin kayanta na magunguna tare da asalin magani. Cedirƙira a cikin Hungary da taimaka ƙananan cholesterol. Kudinsa - 510-1700 rubles.
3. Harshen Ros Kayan aiki mai inganci wanda ake siyarwa a farashi mai araha. Kafin amfani dashi, yana da shawarar karanta umarnin don rage yiwuwar tasirin sakamako daga amfanin sa. Kudin a kan matsakaitan jeri daga 250 zuwa 790 rubles.
4. Rosucard. Wani abokin Rasha. Abunda yake aiki daidai yake, haka kuma sashi a cikin kwamfutar hannu guda. Contraindicated idan akwai wani wuce kima ji wa sinadaran aiki.
5. Rosulip. Amfani da wannan magani ya dace a cikin yanayin hypercholesterolemia na farko, hypertriglyceridemia, don rage ci gaba na atherosclerosis da kuma rigakafin cututtukan zuciya. An samar dashi a cikin Harshen Hungary kuma yana biyan 390-990 rubles.
6. Roxer. Magungunan ƙwaƙwalwar ƙwayar cuta. Ba'a ba da shawarar yin amfani da shi ba lokacin daukar ciki, yayin shayarwa, har ma da yara 'yan ƙasa da shekaru 18. Matsakaicin farashin shine 440-1800 rubles na Rasha.
7. Tevastor Magungunan da dole ne a yi amfani da shi aƙalla makonni 4 don sakamako mai tasiri. An yi shi a cikin Isra'ila kuma farashin yana kusan 350-1500 rubles.
8. Novostat. Babban sinadaran aiki shine atorvastatin. An samar da miyagun ƙwayoyi a Rasha.

Farashin waɗannan kwayoyi ya bambanta kuma ya bambanta daga 500 rubles zuwa 3 dubu ko fiye.

Nazarin marasa lafiya da likitoci game da Crestor

Dangane da ra'ayin kwararrun likitoci, Krestor ya tabbatar da cewa ya zama wani ingantaccen magani wanda ya taimaka rage jini cholesterol.

A cikin yawancin marasa lafiya da ke halartar gwajin, alamar cholesterol na gabatowa al'ada a cikin mako guda, bayan fara karatun.

Allunan akan kasuwar magani suna da inganci, sabili da haka amfanin yin amfani da miyagun ƙwayoyi ya fi ƙaruwa. A matsayinka na mai mulkin, hanyar wannan maganin ba ya haifar da sakamako masu illa.

Amma game da ra'ayin marasa lafiya, ya zo daidai da ra'ayin likitoci. Mafi yawan lokuta, akwai ra'ayoyin marasa lafiya da suka sami bugun jini ko bugun zuciya.

Don haka, zamu iya yanke hukuncin cewa magani yana da tasiri sosai. Yana ɗaukar lokaci kawai don alamun zasu dawo al'ada.

Shin zan ɗauka gumaka zan gaya wa gwani a cikin bidiyon a wannan labarin.

• Yana daidaita matakan sukari na dogon lokaci
• Maido da aikin samarda insulin

Pharmacology

Wani wakilin zubar da jini daga rukunin mutum-mutumi, mai hanawa na HMG-CoA reductase. Dangane da ka’idar gwagwarmayar gwagwarmaya, satin kwayar zarratin an sanya wa wani sashi na coenzyme A receptor inda wannan enzyme yake. Wani sashin kwayar halittar statin yana hana canza hydroxymethylglutarate zuwa mevalonate, wani tsaka-tsaki a cikin kwayar kwayar cholesterol.Haramcin ayyukan HMG-CoA reductase yana haifar da jerin abubuwanda suka biyo baya, sakamakon hakan ya haifar da raguwar abubuwanda ke cikin ƙwayar kwalliya da karuwar ragi a cikin ayyukan masu karɓa na LDL kuma, a sakamakon haka, ana kara hanzarin catabolism na LDL cholesterol (Xc).

Sakamakon cututtukan jini na jikin mutum yana da alaƙa da raguwa a matakin jimlar cholesterol saboda ƙwayoyin LDL. Ragewar LDL ya dogara da kashi-kashi kuma ba layi bane, amma ingantacce.

Statins ba su shafi ayyukan lipoprotein da hepatic lipases, ba su da tasiri sosai a kan tsarin haɗin gwal da catabolism na kitse mai ƙoshin mai, don haka, tasirin su a matakin TG shine sakandare kuma kai tsaye ta hanyar manyan tasirin su akan rage darajar LDL-C. Rage matsakaici a cikin matakin TG yayin jiyya tare da statins yana da alama yana da alaƙa da bayyana ragowar (apo E) masu karɓa a farfaɗo na hepatocytes da ke da hannu a cikin catabolism na STDs, wanda ya ƙunshi kusan 30% TG.

Baya ga tasirin lipid, ƙananan siffofi suna da tasirin gaske akan lalatawar ƙwaƙwalwar ƙwaƙwalwa (ƙayyadadden alamar farkon atherosclerosis), a kan bango na jijiyoyin bugun gini, yanayin atheroma, haɓaka ƙimar rheological jini, suna da antioxidant, antiproliferative Properties.

An bayyana tasirin warkewa a cikin mako 1. bayan farkon farfajiya da kuma bayan sati 2 na jiyya shine 90% na mafi girman tasirin sakamako, wanda akasari yakan samu ne sati 4 sannan bayan hakan ya kasance kullum.

Analogs ta hanyar nuni da hanyar amfani

Abun daban-daban, na iya daidaituwa cikin nuni da hanyar aikace-aikace

Don yin jerin samfuran analogues masu tsada na magunguna masu tsada, muna amfani da farashin da ke ba mu magunguna sama da 10,000 a duk Rasha. Ana sabunta bayanan magungunan kwayoyi da kuma hanyoyin shigar su na yau da kullun, don haka bayanin da aka bayar akan shafin yanar gizon mu koyaushe yana kan lokaci har zuwa yau. Idan baku sami wani analog na sha'awar ku ba, don Allah yi amfani da binciken da ke sama kuma zaɓi maganin sha'awar ku daga jeri. A shafin kowane ɗayansu zaku iya samun zaɓuɓɓuka masu yiwuwa don analogues na maganin da ake so, da farashin da adreshin magunguna wanda yake akwai su.

Wadanne analogues ne zasu iya maye gurbin rosuvastatin?

Rosuvastatin magani ne wanda aka yi amfani dashi don gyara metabolism na mai. Ana amfani da maganin sosai don yin rigakafi da magani daga cututtukan cututtukan zuciya.

Shirye-shiryen da suka ƙunshi rosuvastatin azaman abu mai aiki ana samarwa ne daga masana'antun ƙasashen waje da na gida da yawa. Maganin asali da ake kira Crestor an yi shi a Burtaniya ta Astra Zeneca. Sauran magungunan da ke ɗauke da rosuvastatin sune ƙwayoyinta.

Misali, Rosuvastatin Canon, Torvacard, Rosulip, Akorta, Rosistark, Tevastor, Rosart, Rosuvastatin-SZ, Mertenil.

Rosuvastatin "za'a iya maye gurbin shi da wani kyakkyawan analog

Magunguna na asali da ƙwayoyin cuta

Menene kwayoyin halitta kuma ta yaya suka bambanta da na asali? Kwayoyin kwayar halitta ana kwafin kwafin magungunan asali. Abubuwan da ke aiki a cikin asalin magani da ƙwayoyin cuta iri ɗaya ne. Kuma abun da ke ciki na taimakawa zai iya bambanta.

Me yasa analogues mai rahusa fiye da na asali? Gaskiyar ita ce cewa masana'anta na asali samfurin "majagaba" ne.

Wannan yana nufin cewa yana kashe kuɗi masu yawa don gudanar da karatun asibiti da kuma nazarin asibiti, ya kuma sami lamunin sabon magani. Waɗannan hanyoyin masu tsada suna haɗuwa da tsadar maganin.

Masu kera nau'ikan ƙwayoyin cuta ba sa ɗaukar irin waɗannan farashi mai sauƙi, suna kawai ƙirƙirar kayan aiki, wanda ya ba su damar siyar da shi a kan ƙananan farashi mai ƙima.

Don haka, la'akari da wani magani wanda shine kwatankwacin asalin Rosuvastatin (Crestor).

Masu ciwon sukari yayin jiyya tare da Krestor ya kamata suyi hankali sosai

Rosuvastatin Canon

Suchaya daga cikin irin wannan magani shine Rosuvastatin Canon. Ana samun magungunan a cikin nau'ikan allunan 10, 20 da 40 MG. Magani yana da kayan rage rage kiba. Alamu game da nadin Rosuvastatin Canon sune:

• na farko hypercholesterolemia,
• familial dangin hypercholisterinemia,
• dagagge jini triglycerides,
• rigakafin rikitarwa na atherosclerosis,
• rigakafin rikitarwa na IHD ba tare da alamun asibiti ba,
• kari ga abinci a hadarin haɓakar atherosclerosis.

Ana amfani da maganin ta hanyar dogon darussan na jiyya, farawa da ƙaramin matakin. Makonni 3-4 bayan fara magani, an wajabta wa mara lafiya gwajin jini don lura da tasirin magani.

Idan matakin cholesterol da triglycerides a cikin jini ya kasance mafi girma ko rage dan kadan, sashi na miyagun ƙwayoyi ya kamata a daidaita.

Ana kara yawan kashi a hankali tare da duba lokaci-lokaci na kirga jini.

Rosuvastatin Canon - Wani wakili na zubar da jini daga rukuni na mutum-mutumi, mai hanawa na HMG-CoA reductase

Yaushe bai kamata a kirkiri statins ba?

Rosuvastatin, kamar sauran gumakan, yana da contraindications da yawa, a cikin abin da aka hana shi sanya magunguna na wannan rukuni.

1. Rashin yarda da abu mai aiki ko abubuwan taimako na nau'in sashi.
2. Cututtukan hanta a cikin aiki mai aiki ko haɓaka matakan transaminases na asalin da ba a sani ba fiye da sau 3.
3. Lokacin haihuwar jariri da shayarwa.
4. Rashin isasshen rigakafin cikin mata masu haihuwa.
5. Cutar koda tare da bayyanar rashin nasara na koda.
6. Yara da matasa da ke ƙasa da shekara 18.
7. Cutar zuciya
8. Tsawon lokacin jiyya tare da cyclosporine.

Ya kamata a kula da maganin rigakafin Rosuvastatin Canon cikin la'akari lokacin nada shi. Wannan zai nisantar da ci gaban halayen da ake samu daga gabobin jiki da tsarin.

Matsaloli da ka iya faruwa na rsuvastatin far

Wadanne rikice-rikice da rikice-rikice masu yiwuwa ne lokacin da ake bi da su da magungunan asali da maye gurbin rosuvastatin? An yarda da lafiyar Statin gabaɗaya. Wannan ya shafi duka magungunan asali da kuma analogues masu araha na rosuvastatin.

Yin amfani da statins na iya haifar da ciwon tsoka.

Koyaya, idan adadin ya wuce ko kuma akwai matsaloli a ɓangaren sauran gabobin da tsarin, lura da Rosuvastatinomy tare da analogues ɗin na iya haifar da bayyanar halayen da ba a so.

1. Quincke's edema da sauran halayen tsarin rigakafi.
2. Cututtuka na tsarin endocrine (nau'in ciwon sukari na 2).
3. Rashin lafiyar mazaunin ciki.
4. Ciwon ciki na Pancreatic.
5. Rashin lafiyar hanta.
6. Ciwon kirji, myositis, rhabdomyolysis (lalata tsokoki na ƙwayar tsoka).
7. Rashin aikin koda.
8. Canje-canje a cikin dakin gwaje-gwaje na jini da gwajin fitsari.

Idan kun sami wasu alamun cututtukan da ba alamomin cutar ta sankara ba, ya kamata ku nemi shawarar likita nan da nan. Kwararrun zai yi daidai asalin asalin cutar kuma idan ya cancanta, daidaita tsarin kulawa da sashi.

Dokoki don shan kwayoyi

Yadda ake ɗaukar Rosuvastatin da misalanta? Magungunan da suka dace suna ba da iyakar tasirin warkewa da rage haɗarin rikice-rikice na sama na maganin. Don haka, mahimman ka'idodin magani kamar haka.

1. Ya kamata a sha miyagun ƙwayoyi gaba ɗaya, ba tare da taunawa ba. Sha maganin tare da tsayayyen ruwa a wadatacce.
2. Idan kana son daukar karami kadan fiye da ya ƙunshi kwamfutar hannu ɗaya, za'a iya raba nau'ikan sashi cikin rabi.
3. Matan mata masu haihuwa yayin haila dole suyi amfani da hanyoyin ingantattun maganin hana haihuwa.
4. Game da ciki yayin yin jiyya tare da statins, ya kamata a dakatar da maganin. Ba a bukatar zubar da ciki.
5. Yayin maganin, an haramta shi don rage kansa ko haɓaka yawan maganin yau da kullun.
6. Idan aka rasa magungunan ba da gangan, ya kamata a ci gaba da ƙarin magunguna gwargwadon tsarin da aka saba.

Masana sun ba da shawarar daukar mutum-mutumi a kashin kansa

Ya kamata kuma a san cewa bisa ga asalin maganin jijiyar statin, kuna buƙatar bin abinci mai ƙarancin mai da cholesterol. Abincin ya kamata ya zama mai ƙarancin kalori, ya ƙunshi ƙarancin dabbobi kamar yadda zai yiwu.

Kifaye iri iri na kifaye, nama da kayan kiwo yakamata a cire su gaba daya. Ya kamata ya haɗa da isasshen furotin da fiber na shuka.

Kamar yadda abincin furotin, kaza, turkey, cuku gida, da madara mai ƙanshi sun dace.

Ya kamata ku ci karin kayan lambu, 'ya'yan itatuwa, ganye, ruwan' ya'yan itace sabo. Guji cin abinci mai kitse, soyayyen abinci da kyafaffen abinci. Rage barasa, abinci mai sauri da soda.

Kuna iya dafawa ta amfani da tukunyar jirgi biyu, ta yin burodi, tafasa. Yana da kyau kada kuyi amfani da mai, kayan ƙanshi da kayan ƙanshi mai zafi a dafa abinci.

Yarda da ka'idodin abinci mai gina jiki sun ƙayyade nasarar magani.

Wanne magani ne mafi kyau?

Don haka, komawa zuwa ga analogues na Rosuvastatin, ya kamata a faɗi cewa watakila suna iya maye gurbin ainihin maganin. Kuma duk da haka, Wanne ya fi kyau - ainihin ko labarin? Tabbas ba zai yiwu ba a amsa tambayar, tunda akwai ra'ayoyi daban-daban na kwararru kan wannan.

Wasu sun yi imani da cewa asalin maganin yana da “tsabta” kuma wataƙila zai haifar da halayen da ba a so. Bugu da kari, wasu likitocin suna lura da ingantaccen aikin asali fiye da takwarorinsu.

Saboda haka, likita zai iya jagorantar shi ta hanyar la'akari daban-daban, yana rubuta wa mai haƙuri duka asalin magani da kuma maganganunsa.

Binciken cikakken bayani game da shahararrun kwayoyi masu alaƙa da tsadar kwayar cutar "Rosuvastatin"

Rosuvastatin yana daya daga cikin ingantattun magunguna masu amfani da halayya masu rage zafin jiki. Idan, saboda dalilai da yawa, alal misali, karancin kantin magani na gida ko farashi mai tsada, mai haƙuri ba zai iya siyan maganin na ainihi ba, to ana iya maye gurbin sa ta hanyar analog mai araha, wanda akwai Rosuvastatin da yawa.

Babban bayani game da miyagun ƙwayoyi da umarnin don amfani

Rosuvastatin (Rosuvastatin) - Wannan magani ne wanda yake rage karfin jiki na karshe na IV (sabo) daga wani rukunin kungiyar magunguna da ke jikin mutum-mutumi, sashi mai aiki wanda shine sinadaran sunadarai guda suna rosuvastatin a cikin nau'in gishiri na alli (roissa rosuvastatin).

Wannan magani an yi shi ne don gyaran ƙwayar cholesterol a koda yaushe (hypercholesterolemia), wanda ba shi da matsala ga magani tare da hanyoyin da ba magunguna ba. Hakanan an wajabta shi a matsayin ɓangare na hadaddun farfaɗo na wasu nau'ikan na metabolism mai rauni (dyslipidemia), don rigakafin rikitarwa na zuciya da kawar da canje-canje na atherosclerotic akan bangon jijiyoyin jini.

Ayyukan statins ya dogara ne da hana enzyme, wanda ke da alhakin samar da cholesterol ta hanta (tushen kusan kashi 80% na abubuwan).

Hanyar aikin Rosuvastatin ta ƙunshi toshe enzyme - HMG-CoA reductase, wanda shine "magadan" na ƙarshen ƙwayar cholesterol (Chol, cholesterol) a cikin hanta. Saboda wannan, yawan masu karɓar raunin lipoproteins mai yawa yana ƙaruwa, wanda ke kunna aiwatar da lalacewar su da cirewa daga jiki.

A sakamakon haka, a kan asalin amfani da miyagun ƙwayoyi, akwai raguwa a cikin taro na "mummunan" cholesterol (LDL, LDL), kuma matakin "mai kyau" cholesterol (HDL, HDL) a cikin jini kuma yana ƙaruwa diyya.

Ana samun magungunan a cikin nau'ikan allunan da aka sanya fim, wanda dole ne a cinye shi na ciki kawai (a baki), tare da aƙalla ruwa na 100-150, a kowane lokaci na rana, ba tare da la'akari da abinci ba.

Abinda aka kirkira na Rosuvastatin ya hada da sukari madara (lactose) monohydrate, kasancewar hakan yasa likitan ya zama ba zai iya zama ba ga marasa lafiya tare da rashin jituwa ga wannan bangaren da kuma mutanen da ke fama da lactase.

Bayanin jiyya An zabi Rosuvastatin da likita yayi daidai da daidaikun mutane, gwargwadon tsananin a cikin kowane yanayi. Yanayin aiki yana farawa da mafi ƙarancin kashi (5-10 mg sau ɗaya a rana) kuma yana ƙaruwa kamar yadda ya cancanta (muddin ba akwai sakamako masu illa).

Za'a iya lura da sakamako mai laushi mai laushi bayan kwana 7-9 bayan farawar, sannan bayan makonni 2-4 ya kai 90-100% na sakamakon da yakamata, wanda aka kiyaye gaba ɗayan tsarin na yau da kullun na Rosuvastatin.

Wanne masana'anta suka fi kyau?

Maganar asali ta Rosuvastatin da kamfanin Japan ya kirkiro shine Shionogi & Co. (Shionogi & Co), duk da haka, analololo analogues ana samarwa a karkashin sunan da ba na gwamnati ba (INN) ta wasu kamfanonin harhada magunguna:

• Rashanci - Pharmstandard (Phstandard), Ozone (Ozon), Canonfarma (Kanonfarma), FI Obolenskoye (OBL Pharm),
• kasashen waje - Astra Zeneca (Astra Zeneca), Gideon Richter (Gedeon Richter), Actavis (Actavis), Belupo (Belupo).

Duk waɗannan kamfanonin suna samar da ƙwayoyin cuta, i.e., kwafin kwayoyi, sashin aiki mai aiki wanda shine rosuvastatin iri ɗaya, amma sun bambanta da farkon ci gaba ta hanyar fasaha na samarwa, sunan cinikayya da rabo na tsofaffi.

Tunda irin wannan analog ɗin kai tsaye ya kusan kasancewa daidai da asali, daga lafazin ingancinsa, ba shi da matsala ga kamfanin da zai ba da fifiko ga lokacin siye, amma idan aka ɗauki Rosuvastatin na wani lokaci mai tsawo, yana da ma'ana ya mai da hankali ga magungunan gida masu rahusa.

Shahararrun analogues da maye gurbin rosuvastatin

Kafin yin la'akari da takamaiman analogues da maye gurbin Rosuvastatin, yana da mahimmanci a lura cewa, duk da nadin likita, mai haƙuri yana da 'yancin zaɓin gwargwadon ikon da ya dace, yana mai da hankali kan abubuwan da ya zaɓa, walat da rashin haƙuri na ƙarin kayan aiki a cikin abun da ke ciki. Babban abu shine bin ka'idodin maganin da aka nuna da kuma maganin.

Roxera yana da takaddara mai ƙarfi musamman wacce ke ba da damar a saki rosuvastatin ta musamman a cikin ƙananan hanjin, inda allunan suna shan ba a canzawa ba, kuma ba a ƙarƙashin tasirin lalacewa na ruwan 'ya'yan itace na ciki.

Siffofin abubuwan da aka tsara: butyl methacrylate da methyl methacrylate copolymers sun kara da kwasfa.

Kamfanin masana'antu: KRKA, Slovenia.

Kudin magani: daga 383 RUB / 30 inji mai kwakwalwa MG 5 zuwa 1617 rubles / 90 inji mai kwakwalwa. 20 MG kowane.

Rosucard (Rozucard) ana nuna shi ta hanyar bioavailability mai kyau (sama da 20%), amma rosuvastatin abu mai aiki yana fitowa ne da sauri daga jiki, sabili da haka miyagun ƙwayoyi suna da tasiri mai warkewa.

Siffofin abubuwan da aka tsara: maimakon hypromellose daga asali na asali, ana amfani da croscarmellose a matsayin foda na yin burodi.

Kamfanin masana'antu: Zentiva, Czech Republic.

Kudin magani: daga 613 rub. / 30 inji mai kwakwalwa. 10 MG zuwa 2708 rubles / 90 inji mai kwakwalwa. 40 MG kowane.

Likitocin sun bada shawara

Don rage tasirin cholesterol yadda ya kamata da hana atherosclerosis ba tare da sakamako masu illa ba, masana sun bada shawarar choledol. Magungunan zamani:

• dangane da amaranth da aka yi amfani da shi wajen magance cututtukan zuciya,
• yana haɓaka samar da “mai kyau” cholesterol, rage haɓakar “mara kyau” ta hanta,
• yana rage hadarin kamuwa da ciwon zuciya da bugun jini,
• fara aiki bayan mintuna 10, ana samun sakamako mai mahimmanci bayan makonni 3-4.

An tabbatar da inganci ta hanyar aikin likita da bincike na Cibiyar Bincike na Nazari.

Mertenil (Mertenil) yana da babban matakin tsarkakewa daga cikin kayan aiki mai aiki. Wannan yana tabbatar da kyakkyawan haƙuri na ƙwayoyi tare da ƙananan sakamako masu illa, wanda yake mahimmanci musamman lokacin shan rosuvastatin a cikin tsofaffi marasa lafiya.

Siffofin abubuwan da aka tsara: ya zo daidai da na asali, sai dai abubuwan da ake amfani da su don zane zanen harsashi.

Kamfanin masana'antu: Gedeon Richter, Hungary.

Farashin kuɗi a cikin kantin magani: daga 478 rub. / 30 inji mai kwakwalwa. MG 5 zuwa 1439 rubles / 30 inji mai kwakwalwa. 40 MG kowane.

Rosulip (Rosulip) analogue mai sauƙi ne na Rosuvastatin, wanda ke da babban bioavailability kuma sannu a hankali yana tarawa, wanda zai ba ka damar ƙirƙirar hankali na warkewar abubuwan da ake so a cikin jiki.

Siffofin abubuwan da aka tsara: ya ƙunshi rosuvastatin ba a cikin nau'in ƙwayar kalsami ba, amma a cikin nau'in gishiri na zinc (rosuvastatin zinc).

Kamfanin masana'antu: EGIS (EGIS Pharmaceuticals PLC), Hungary.

Kudin magani: daga 469 RUB / 28 inji mai kwakwalwa MG 5 zuwa 1087 rubles / 28 inji mai kwakwalwa. 20 MG kowane.

Crestor (Crestor) - magani na asali wanda ya dogara da rosuvastatin. Wannan magani da aka shigo da shi an nuna shi ta hanyar ingantaccen aiki na kayan aiki kuma, bisa la’akari da haƙuri, an fi haƙuri, amma a farashi ya fi tsada fiye da sauran ƙwayoyin cuta.

Siffofin abubuwan da aka tsara: Duk kayan abinci iri ɗaya ne da girke-girken asali.

Kamfanin masana'antu: Astra Zeneca, United Kingdom.

Farashin kuɗi a cikin kantin magani: daga 1756 rub. / 28 inji mai kwakwalwa. 5 MG kowane zuwa 5036 rub./28 inji mai kwakwalwa. 40 MG kowane.

Tevastor yana ɗayan mafi kyawun analogues na Rosuvastatin, saboda yana haɗuwa da sauri a cikin jiki, yana yin tasirin maganin warkewa, kuma a lokaci guda yana da araha mafi tsada fiye da na asali.

Siffofin abubuwan da aka tsara: kusan lenten iri ɗaya kamar na asali (sai dai fenti).

Kamfanin masana'antu: TEVA (TEVA Pharmaceutical masana'antu Ltd), Isra'ila.

Kudin magani: daga 341 rub. / 30 inji mai kwakwalwa. MG 5 zuwa 1522 rubles / 90 inji mai kwakwalwa. 20 MG kowane.

Rosuvastatin-SZ

Rosuvastatin-SZ (Rosuvastatin-SZ) - a yau shine mafi sauƙin canji ga Rosuvastatin daga masana'anta na Rasha. Duk da farashin mai ƙanƙantar da kai, ba shi da ƙima ga wasu ilimin halittu kuma yana da kaddarorin iri ɗaya da na asali.

Siffofin abubuwan da aka tsara: baƙin ƙarfe baƙin ƙarfe da aka yi amfani da shi azaman maye gurbinsa da alherin fata na abubuwa uku.

Kamfanin masana'antu: FC Severnaya Zvezda ZAO, Rasha

Kudin magani: daga 178 rub. / 30pcs. MG 5 zuwa 684 rubles / 30 inji mai kwakwalwa. 40 MG kowane.

Baya ga statins, akwai wasu hanyoyi. Masu karatu sun bada shawara magani na halitta, wanda, haɗe tare da abinci mai gina jiki da aiki, yana rage tasirin cholesterol bayan makonni 3-4. Ra'ayin likitoci >>

Rosart (Rosart) yana da duk fa'idodin magani na asali kuma da wuya yana da mummunar tasiri a jikin mutum, saboda duka kayan aiki masu aiki da kayan haɗin taimako suna tsabtace da kyau. Zamu iya cewa wannan shine mafi cancantar maye gurbin rosuvastatin.

Siffofin abubuwan da aka tsara: dukkan sinadaran iri daya ne kamar yadda ake gabatar da su na asali.

Kamfanin masana'antu: Actavis Group, Iceland

Farashin kuɗi a cikin kantin magani: daga 426 RUB / 30 inji mai kwakwalwa 5 MG zuwa 2347 rub./90 inji mai kwakwalwa. 40 MG kowane.
Samfura waɗanda ke rage cholesterol kuma suna tsarkake tasoshin jini.

Dukkanin kwayoyi mafi inganci don tasirin cholesterol.

Rashin ƙanƙantar da magunguna da maye gurbin magungunan giciye don yara da manya

Magungunan Krestor shine maganin rage karfin rage kiba a cikin rukunin jini.

Abunda yake aiki shine rosuvastatin, wanda yake rage yawan kuzari, yana kawar da nakasar endothelial a farkon atherosclerosis, inganta yanayin tasoshin jini, yanayin atheroma, da kuma ayyukan rheological jini. An lura da cututtukan antioxidant da magungunan rigakafi a jiki.

Abubuwan da ke nuna alama don amfani sun haɗa da yanayin hypercholesterolemia, gami da familial homozygous. Contraindications ga miyagun ƙwayoyi sune kamar haka: ciki, lactation, yara da balaga har zuwa shekaru 18, cutar hanta, cutar koda, a cikin aiki mai aiki.

Magungunan da aka samar a cikin Burtaniya da Puerto Rico suna da alamun maye da ma’anoni. Farashin allunan Krestor bai kasance ga kowane mai haƙuri ba: 800-9900 rubles. Masu siraran magunguna masu araha masu saukin gaske sune masu siyarwar gida da waje.

Analogs na samarwa na Rasha

Maƙerani na Yukren

Yadda za a maye gurbin masanin magunguna, idan kuna buƙatar zaɓar synonym mai ƙoshin tsada? Magungunan Yammacin Ukraine sun haɗa da jeri a ƙasa.

• Klivas. Mafi ƙarancin analog na giciye a cikin nau'ikan Allunan. Abun da ke cikin miyagun ƙwayoyi ya haɗa da rosuvastatin. Magungunan suna da kyau magance halin hypercholesterolemia, kuma ana amfani dashi a cikin rigakafin cututtukan zuciya. Matsakaicin matsakaici shine 10-155 rubles.
• Atorvacor. Atorvastatin a cikin tsarin maganin yana yin tasirin lipid, rage ƙwayar ƙwayar plasma. Wurin aiwatar da miyagun ƙwayoyi shine ƙwayoyin hanta, sabili da haka, daga cikin manyan contraindications shine gazawar hanta .. Hakanan an haramta maganin a yayin daukar ciki da lactation. Matsakaicin farashin shine 140-220 rubles.

Kwayoyin Belarusian

Abubuwan ƙetare na Belarusian shine mafi kyawun sauyawa don magunguna masu ƙarancin lipid tare da bayanai iri ɗaya a cikin umarnin don amfani.

An gabatar da tebur a ƙasa:

Sauran analogues na kasashen waje

Daidaita fassarar zamani na gicciye akan rosuvastatin:

• Mertenil. Abunda yake aiki shine rosuvastatin. Abubuwan da ke nuna alamun rubuta magungunan sun hada da yanayin dysliplera don rage cholesterol .. Mafi kyawun analog na ƙasashen waje na giciye a cikin kayanta na magunguna. Ofasar Asalinta - Hungary. Matsakaicin matsakaici shine 510-1700 rubles.
• Harshen Ros. Wani ingantaccen magani wanda aka shigo da shi akan rosuvastatin akan farashi mai araha. An ba da shawarar karanta umarnin don amfani don contraindications, sakamako masu illa da kuma yanayin da ke buƙatar kulawa yayin aikin jiyya An samar da maganin a cikin Croatia. Matsakaicin matsakaici shine 250-790 rubles.
• Tevastor. Daidaita ma'anar maganin da ake tambaya tare da irin tsarin aikin. Ana shan magani na dogon lokaci - ana lura da barkewar warkewar cutar bayan makonni 4 bayan fara shan magani .. countryasar asalin Isra'ila shine. Matsakaicin matsakaici shine 350-1500 rubles.
• Roxer. Wakili mai saurin rage karfin jiki tare da aiki mai kama da giciye. An haramta maganin a lokacin daukar ciki, shayarwa, yara 'yan kasa da shekaru 18. Magungunan Slovenian na Magani. Matsakaicin matsakaici shine 440-1800 rubles.
• Rosulip. Allunan tare da rosuvastatin a cikin abun da ke ciki sun rage yawan tattarawar cholesterol a cikin jini .. Amfani da magani yana da mahimmanci ga hypercholesterolemia na farko, hypertriglyceridemia, homozygous hereditary hypercholesterolemia, don hana ci gaban atherosclerosis, da kuma a cikin hanyoyin rigakafin cututtukan zuciya. Matsakaicin farashin shine 380-1990 rubles.

Da fatan za a lura, analolera na miyagun ƙwayoyi na iya samun bambancin ƙarfi na tasirin warkewa a jikin kowane haƙuri. A cikin umarnin don amfani, ana iya nuna halayen masu illa da contraindications da yawa. Likita na iya ba da maganin rage rage kiba.

Kula da jijiyoyin jiki na iya haifar da jin zuciya, saboda haka bai kamata ku shiga cikin ayyukan da ke buƙatar haɓakar maida hankali sosai ba.

Umarni Crestor

INGANTA
don amfani da magani
KYAUTA

Aikin magunguna
Crestor wakili ne na rage kiba. Abubuwan da ke aiki da ƙwayar cuta shine rosuvastatin - mai hanawa mai zaɓi na HMG-CoA reductase, enzyme wanda ke canza 3-hydroxy 3-methylglutaryl coenzyme A zuwa farkon cholesterol - mevalonate. Matsayin aikace-aikacen aiwatar da aikin rosuvastatin shine hanta, inda akwai catabolism na low yawa lipoproteins (LDL) da samuwar cholesterol (CS). Rosuvastatin yana ƙara yawan masu karɓar hepatic don ƙananan lipoproteins mai yawa a cikin membranes na sel, wanda ke haifar da karuwar catabolism da haɓaka ƙarancin lipoproteins da yawa (VLDL). Sakamakon haka, akwai raguwa a cikin abubuwan da ke cikin ƙananan ƙwayoyi masu ƙarancin ƙarfi a cikin ƙwayoyin magani.
Rosuvastatin yana rage matakan haɓaka na jimlar cholesterol, triglycerides da LDL cholesterol, apolipoprotein B (ApoV), cholesterol na VLDL, ƙwaƙwalwar rashin HDL, ƙwaƙwalwar VLDL, jimlar LDL cholesterol / HDL cholesterol, jimlar LDL cholesterol / LDL / I. Rosuvastatin dan kadan yana kara abun ciki na HDL cholesterol da ApoA-I (apolipoprotein A-I).
Matsakaicin tasirin Krestor yana haɓaka bayan kwana 21 na shigarwar kuma ya kasance koyaushe. Bayan kwanaki 7 na shan miyagun ƙwayoyi, ana lura da tasirin warkewa na Krestor, kuma bayan kwanaki 14 na shan miyagun ƙwayoyi, tasirin maganin shine 90% na mafi girman yiwu.
An tsara miyagun ƙwayoyi don manya tare da ko ba tare da hypertriglyceridemia ba kuma tare da hypercholesterolemia, ba tare da la'akari da shekaru, jinsi ko tsere ba. Hakanan za'a iya amfani da miyagun ƙwayoyi a cikin marasa lafiya tare da familial hypercholesterolemia ko ciwon sukari mellitus.
Duk da yake shan Krestor a cikin sashi na 10 MG a cikin 80% na marasa lafiya tare da matsakaicin matakin LDL cholesterol na 4.8 mmol / L (hypercholesterolemia IIa da nau'ikan), an lura da raguwa a cikin LDL cholesterol zuwa ≤3 mmol / L.A cikin marasa lafiya tare da hypercholesterolemia na familial wanda ke karɓar ƙwayar a cikin sashi na 20-80 MG, an lura da ingantaccen canji a cikin bayanan furotin (an gudanar da binciken asibiti tare da halartar marasa lafiya na 435).
An lura da raguwa a cikin ƙwayoyin LDL cholesterol ta hanyar 53% tare da maganin Crestor na mako-mako 12 bayan ƙaddamar da kashi 40 na MG / rana, kuma an cimma matakan LDL na cholesterol ≤3 mmol / L a cikin 33% na marasa lafiya. A cikin marasa lafiya tare da hypercholesterolemia na familial, ana sanya magani a cikin kashi 20 da 40 mg, kuma a kan asalin maganin Krestor, raguwar LDL cholesterol ya kasance 22%.
Lokacin da aka haɗe shi da fenofibrate, an yi rijistar tasirin ƙari (matakin triglyceride), wanda aka lura da shi yayin da aka haɗa shi da nicotinic acid (dangane da HDL cholesterol).
Duk da yake babu bayanai don kimanta raguwa a cikin yawan rikitarwa da ke haifar da rikicewar bayanan lipid (alal misali, cututtukan zuciya na zuciya), gwaji na asibiti yana gudana.
An lura da mafi yawan abubuwan aiki a cikin jini na jini kamar awa 5 bayan amfanin Krestor na ciki. Bioavailability kusan 20%. Cumulates a cikin hanta. Ofimar rarraba rosuvastatin shine lita 134. Kimanin kashi 90% na maganin da aka gudanar an ɗaure shi da ƙirar plasma (albumin).
Kimanin 10% na kashi rosuvastatin yana ɗaukar iyaka metabolism. Rosuvastatin abu ne maras amfani ga metabolism wanda tsarin cytochrome P450 ke aiwatarwa. Babban enzyme wanda metabolizes rosuvastatin shine CYP 2C9. Zuwa mafi ƙarancin, enzymes CYP 3A4, CYP 2C19 da CYP 2D6 suna cikin metabolism na rosuvastatin. Babban metabolites na abu mai aiki shine lactone metabolites da N-dismethyl. Lokacin da aka gwada su, ya juya cewa N-dismethyl kusan rabin (50%) ba shi da aiki fiye da rosuvastatin. An ƙaddara cewa lactone metabolites ba su da ƙwaƙwalwar magunguna.
Matsakaicin tsabtace geometric na rosuvastatin shine kusan 50 l / h tare da daidaituwa na bambancin 21.7% Kusan 90% na maganin da aka gudanar an cire shi ba tare da canzawa ba tare da jijiyoyin wuya, duka rosuvastatin da ba a kwashe su ba kuma an kwashe su. Kashi 10% na kayan yana cirewa ta hanta. Rabin rayuwa kusan awanni 19 ne, wanda yake tare da kara yawan sashi. A cikin aiwatar da haɓakar hepatic na kwayar halitta mai aiki (kamar yadda yake tare da sauran masu hana HMG-CoA reductase inhibitors), mai ɗaukar kwayar cholesterol, wanda ke taka muhimmiyar rawa wajen kawar da rosuvastatin ta hanta.
Tsarin bayyanar rosuvastatin yana ƙaruwa gwargwadon yawan aikin da aka gudanar. Game da shan allurai na yau da kullun na miyagun ƙwayoyi, sigogi na pharmacokinetic na kayan Krestor ba su canzawa.
Binciken kwatancen a cikin marasa lafiya da ke zaune a Asiya (tsere na Asiya) ya bayyana karuwa a cikin AUC da haɓaka da yawan rosuvastatin ta hanyar sau 2, idan aka kwatanta da bayanai daga Turawa da ke zaune a Turai da Asiya. Ba a gano tasirin abubuwan da suka shafi muhalli da abubuwan gado a sakamakon bambancin da ya haifar a cikin sigogin magunguna. Ba a sami bambance-bambance masu mahimmanci na asibiti tsakanin masu haƙuri na jinsi na Negroid da Caucasoid a cikin magunguna na rosuvastatin.
Game da aiki na keɓaɓɓen aiki (huhu ko matsakaici), ƙwayar plasma na rosuvastatin da aiki metabolite (N-dismethyl) baya canzawa sosai. A cikin gazawar ƙwayar renal mai ƙarfi tare da matakin sharewar creatinine na ≤30 ml / min, ƙwayar plasma na abubuwan da ke aiki yana ƙaruwa sau 3 (kuma metabolite mai aiki, N-dismethyl, yana ƙaruwa sau 9). Yawan plasma na rosuvastatin a cikin marasa lafiya da ke karɓar ƙwaƙwalwar ajiyar zuciya kusan 50% mafi girma. An gudanar da binciken kwatancen magunguna na rosuvastatin a cikin marasa lafiya da ke fama da cutar koda idan aka kwatanta da rukuni na masu ba da agaji.
Babu wani karuwa a cikin sigogi na rabin rayuwa na abu mai aiki a cikin marasa lafiya da matakan digiri na wucin gadi, waɗanda aka kimanta akan sikelin Yara-Pugh na 7 ko lessasa da maki. Marasa lafiya waɗanda aka kimanta 8 da 9 akan ma'aunin Yara-Pugh sun nuna karuwa da kawar da rabin rayuwa ta aƙalla sau 2. Babu wani gogewa game da amfani da rosuvastatin a cikin marasa lafiya da rashin isasshen hepatic tare da ciwan Yara-Pugh na 9 ko fiye.

Alamu don amfani
· Jiyya na atherosclerosis don rage ci gaba da cutar a cikin marasa lafiya waɗanda aka nuna musu rage rage kiba,
Game da homozygous familial hypercholesterolemia a matsayin ƙari ga wani magani na rage ƙwayar cholesterol (alal misali, LDL-apheresis) ko abinci, har ma a lokuta inda irin wannan magani ba shi da tasiri,
As additionarin ƙari ga abincin - tare da cakuda hypercholesterolemia (nau'in IIB) a cikin yanayin yayin da hanyoyin da ba magunguna ba (asarar nauyi, aikin jiki) da canjin abinci ba su da tasiri,
Na farko nau'in IIa hypercholesterolemia (gami da maganin heterozygous hypercholesterolemia).

Hanyar aikace-aikace
Ana amfani da miyagun ƙwayoyi a baka, a wanke da ruwa, a kowane lokaci na rana, ba tare da la'akari da abincin ba. Kar ku tauna.
An zaɓi kashi na Krestor dangane da martani ga magani da kuma dalilin amfani da rosuvstatin, yayin da yakamata a yi la’akari da matakan lipoprotein manufa. A yayin jiyya tare da miyagun ƙwayoyi, an wajabta mai haƙuri a rage rage cin abinci mai laushi (misali) don ci gaba da amfani.
Game da maye gurbin amfani da sauran HMG-CoA reductase ko don saduwa ta farko na Krestor, ana bada shawarar fara amfani da kashi 5-10 mg / rana. Zabi na kashi ya dogara da alamomin cholesterol na mutum, haɗarin sakamako masu illa da abubuwan haɗari don rikitarwa na gaba daga tsarin zuciya. Tare da rashin isasshen sakamako, zaku iya ƙara yawan sashi na Krestor ba a farkon kwanaki 21 ba bayan fara shan magungunan (tunda tasirin warkewa yana ci gaba ta wannan lokacin). Shan Krestor a cikin kashi 40 MG yana haifar da haɗarin haɗari na sakamako masu illa na miyagun ƙwayoyi idan aka kwatanta da ƙananan magunguna, don haka ƙaddamar da kashi na Krestor zuwa 40 mg / rana an yarda da haɗarin haɓaka rikice-rikice na zuciya (ciki har da marasa lafiya tare da familial hypercholesterolemia) kuma tare da tsananin ciwo. hypercholesterolemia. Asingara yawan sashi zuwa 40 mg / rana ana aiwatar da shi ne kawai idan ba'a sami tasirin da ake buƙata na amfani da Crestor a 20 mg / rana ba, yayin da mai haƙuri ya kamata ya kasance yana ƙarƙashin kulawa ta fuskar lafiya. Musamman hankali ga irin wannan mai haƙuri ya zama dole a farkon kwanakin shan Krestor a cikin kashi 40 MG / rana.
Theara yawan kashi yana da kyau idan akwai ƙarancin sakamako da ake so yayin ɗaukar magani na 20 MG kuma a ƙarƙashin yanayin cewa marasa lafiya zasu kasance a ƙarƙashin kulawa na ƙwararrun masani. Ana ba da shawarar kulawa ta musamman a farkon shan 40 MG na miyagun ƙwayoyi.
Marasa lafiya da keɓaɓɓen bayanin martaba ba su buƙatar daidaita sashi.
Tare da gazawar koda
Marasa lafiya tare da digiri mai sauƙi basa buƙatar daidaita sashi. Ga marasa lafiya da rashin daidaituwa na yara akan yanayin aiki, farawa na rosuvastatin ya zama 5 MG / rana.
Matsakaicin adadin yau da kullun don gazawar ƙarancin ɗan adam shine 40 mg / rana, don gazawar matsakaici na matsakaici (tare da matakin sharewar creatinine ≤60 ml / min) - 20 mg / rana.
Wa'adin Krestor yana contraindicated a cikin marasa lafiya tare da mai girma na koda kasawa.
Tare da gazawar hanta
Babu wani gogewa na amfani da Krestor a cikin marasa lafiyar da ke fama da matsalar hepatic wanda aka kimanta shi akan ƙimar Childe-Pugh na 9 ko fiye. Wa'adin Krestor ga marasa lafiya da cututtukan hanta a cikin aiki yana da tsari.
Kabilun kabilu
An lura da karuwa a cikin tarawar rosuvastatin a cikin marasa lafiya na tseren Mongoloid. Irin waɗannan marasa lafiya suna buƙatar fara rashin lafiya tare da sashi na 5 MG / rana, tare da matsakaicin adadin 20 mg / rana. Wa'adin Krestor ga marasa lafiya na tseren Mongoloid a gwargwado na 40 MG / rana an haɓaka.
Tare da hali na haɓakar cutar kansa
A cikin marasa lafiya da ke da sha'awar faruwar cutar myopathy, kashi na farawa na rosuvastatin ya kamata ya zama 5 mg / rana, matsakaicin kashi - 20 mg / rana. Wa'adin wani kashi na Crestor a 40 mg / rana an contraindicated a cikin irin wannan marasa lafiya.
Side effects
Abinda ya faru na wasu sakamako masu illa, kamar yadda suke tare da sauran masu hana H HC-CoA reductase inhibitors, ya dogara da adadin da akayi amfani dashi.
An kimanta cutarwar sakamako kamar haka: m sakamako masu illa (≥1 / 100, ≤1 / 10), wasu sakamako masu illa (≥1 / 1000, ≤1 / 100), sakamako masu illa (≥1 / 10,000, ≤1] / 1000), sakamako masu rauni sosai (≤1 / 10,000). Abubuwan da ke haifar da sakamako yayin amfani da Krestor ana ƙididdige su azaman yadda aka nuna su da tsayawa akan nasu. Karshen maganin da Krestor ya yi yayin gwaji na asibiti sakamakon abin da ya faru sakamakon sakamako ya kasance 4% ko lessasa.
Daga tsarin mai juyayi: bushewa, ciwon kai (sau da yawa).
Daga gefen tsarin rigakafi: halayen rashin lafiyan (ciki har da angioedema) - da wuya.
Daga fata da kayan aikinta: rashes, itching, urticaria (sakamako masu illa).
Daga tsarin musculoskeletal: rhabdomyolysis da myopathy (da wuya), ciwon tsoka (sau da yawa). Myopathy, ciwon tsoka, da (da wuya) rhabdomyolysis an lura da su a cikin marasa lafiya waɗanda suka ɗauki kowane kashi na Crestor, amma musamman a cikin waɗanda suka yi amfani da sashi na 20 mg / rana. Increaseara yawan dogara-da-ƙaruwa a cikin matakin creatine phosphokinase (KFK), an lura da shi a cikin marasa lafiya waɗanda suka ɗauki Krestor, a mafi yawan lokuta ba a bayyana su ba, a-dai-dai kuma ba tare da alamu ba. Game da haɓaka matakin CPK ta hanyar 5 ko fiye da haka, an dakatar da rosuvastatin.
Daga jijiyoyin mahaifa: maƙarƙashiya, ciwon ciki, tashin zuciya (sau da yawa), pancreatitis (da wuya).
Daga tsarin urinary: furotin furotin. An samu canji a cikin adadin furotin a cikin fitsari a cikin gradation daga rashi zuwa burburin furotin ko sama da biyu ko ƙari a cikin ≤1% na marasa lafiya waɗanda aka rubuta maganin Crestor 10-20 mg / rana. Lokacin ɗaukar kashi 40 MG / rana, yawan irin waɗannan masu haƙuri kusan 3% na marasa lafiya. Lokacin amfani da sashi na Krestor na 20 mg / rana, an lura da ƙara ƙarin yawan adadin furotin a cikin fitsari. Proteinuria a mafi yawan lokuta yana raguwa ko ɓacewa tare da ci gaba da amfani kuma ba alama ce ta ci gaba da cutar koda na haɓaka ko ci gaba da ake da ita ba.
Daga hanta: a cikin ƙaramin adadin marasa lafiya, an lura da karuwar-dogara ga abin da ke cikin transaminases, kamar yadda yake tare da sauran masu hana haɓaka HMG-CoA. Increasearuwar transaminases a mafi yawan lokuta ya kasance na lokaci ne, ba tare da alamu ba kuma marasa mahimmanci.
Sauran: asthenia (sau da yawa).
Bayan gabatarwar Krestor a aikace na aikin likita, an kuma yi amfani da abubuwanda suka biyo baya:
Daga tsarin musculoskeletal: zafin hadin gwiwa (da wuya).
Daga tsarin juyayi: polyneuropathy (mara wuya sosai).
Daga tsarin hepatobiliary: hepatitis da jaundice (da wuya sosai).

Contraindications
Diseases Cutar cututtukan hanta a cikin aiki mai aiki, gami da ci gaba da hauhawar matakan transaminases asalin da ba a san shi ba, haka kuma duk wani ƙaruwa a cikin transaminases wanda ke da matakan sau 3 ko sama da yadda aka saba,
Pairarfin ƙarancin ƙarancin tare da keɓantaccen izinin in30 ml / min,
Amfani da cyclosporine lokaci guda,
A lokacin daukar ciki da lactation,
Hypersensitivity na rigakafi da tsarin zuwa rosuvastatin ko wani bangaren na Crestor,
Ba'a ba da magunguna ga marasa lafiya waɗanda ba sa amfani da ingantattun hanyoyin ingantattun maganin hana haifuwa,
Cutar zuciya
A Yawan maganin Crestor a 40 MG / rana an haɓaka shi cikin marasa lafiya tare da haɗarin rhabdomyolysis ko myopathy,
· Shekaru zuwa shekaru 18.

Ciki
An sanya giciye don amfani a cikin mata masu juna biyu. Game da batun nadin uwar da ta shayar da mama, an daina shayar da jarirai nono. Kafin magani tare da Krestor a cikin mata masu haihuwa, ya zama dole a gudanar da gwajin ciki. Yayin shan maganin, ya zama dole a yi amfani da isassun hanyoyin hana haihuwa.

Hulɗa da ƙwayoyi
Tare da yin amfani da cyclosporine da rosuvastatin a lokaci guda, Kungiyar ta AUC ta kasance kusan sau 7 fiye da aya daidai a masu aikin sa kai na lafiya. Amfani da waɗannan magunguna a lokaci guda baya canza ƙwayar plasma na cyclosporine.
A farkon jiyya da kuma lokacin karuwa a cikin Crestor kashi, marasa lafiya waɗanda ke karɓar warfarin da sauran bitaminists na antagonists a lokaci guda, kamar yadda suke tare da sauran masu hana haɓaka HMG-Co-A reductase, na iya samun karuwa a INR - International Normalized Ratio - prothrombin lokaci. Canza Krestor ko rage yawan sashi na haifar da raguwa a cikin INR. Lokacin da ake haɗa Crestor tare da antagonists na bitamin K, ana bada shawarar saka idanu akan INR (lokacin prothrombin).
Amfani guda ɗaya na magungunan rage ƙwayar lipid (alal misali, hemifibrozil) da rosuvastatin suna haifar da ƙaruwa a cikin mafi yawan ƙwayar plasma na rosuvastatin kuma yana ƙaruwa da AUC ta sau 2.
Amfani na lokaci guda na ezetimibe da Krestor bai haifar da canje-canje a cikin yawan ƙwayar plasma na magungunan biyu ba, har ma da AUC. Koyaya, ba a bada shawara don ware hulɗar su ta hanyar magunguna ba tare da haɓaka sakamako masu illa.
Babu hulɗa na pharmacokinetic tare da fibrates da ake tsammanin, amma mai yiwuwa magungunan harhada magunguna zasu iya hulɗa. Hemofibrates, gemfibrozil, sauran fibrates da lipid-low rage allurai na nicotinic acid (a kashi daya daidai da 1 g / rana ko sama da haka) yana iya haɗarin haɗarin haɓakar myopathy yayin ɗaukar shi tare da HMG-CoA reductase inhibitors. Wannan tabbas mai yiwuwa ne saboda gaskiyar cewa waɗannan wakilai suna haifar da farawar myopathy yayin da aka tsara su azaman maganin tafinotinanikan. Sabili da haka, tare da wannan haɗin, ana ba da shawarar cewa marasa lafiya su fara ba da magani na Krestor 5 mg / rana.
A cikin gwaji na kantin magani a cikin masu ba da agaji na lafiya, haɗuwa da Crestor da haɗuwa da masu hana kariya guda biyu (100 mg ritonavor da 400 mg lopinavir) sun haɗu da kimanin ninki biyu na AUC don Crestor. A wannan yanayin, matsakaicin mafi girman rosuvastatin ya karu da kusan sau 5. Ba a yi nazarin hulɗa da sauran masu hana kariyar ba. Lokacin da ake rubuta Krestor ga masu kamuwa da kwayar cutar HIV wadanda ke shan ritonavir / lopinavir yayin amfani da Krestor, ya kamata a yi la’akari da raunin / amfanin fa'ida, musamman idan aka kara yawan magunguna ko kuma a farkon jiyya.
Gudanarwa na lokaci guda na erythromycin da rosuvastatin suna haifar da raguwa a cikin AUC na rosuvastatin da 20% kuma mafi girman yawan ƙwayar plasma da kashi 30 %.Hakaici mai kama da juna yana haɓaka da haɓaka motsin hanji saboda amfanin erythromycin.
Ba a yi nazarin mahimmancin asibiti na hulɗar maganin antacids da Krestor ba. Amfani da antacids a lokaci guda tare da haɗawa cikin abun da ake kira magnesium hydroxide ko aluminium da rosuvastatin yana haifar da raguwa da ƙarshen ƙarshen a cikin jini na jini ta 50%. Idan an sha maganin antacids 2 sa'o'i bayan rosuvastatin, to wannan ba shi da ƙimar magana.
Babu wata ma'amala mai ma'ana da zazzabi tare da digoxin.
Yin amfani da rosuvastatin da na hana juna na lokaci guda yana kara AUC na norgestrel da AUC na ethinyl estradiol da kashi 34% da 26%, bi da bi. Sabili da haka, ya kamata a yi la'akari da yawan ƙwayar plasma yayin ɗaukar matakan hana haihuwa.Ba a yi nazarin sigogin Pharmakoketik a hade da Krestor da magunguna don maganin mayewar hormone ba, amma ba za a yanke irin wannan hulɗa ba. An yi amfani da irin wannan haɗuwa na kwayoyi yayin gwaji na asibiti - duk marasa lafiya sun yi haƙuri da shi sosai.
Sakamakon bincike kan hulɗa a cikin vivo da in vitro sun nuna cewa abu mai aiki na Krestor ba mai ƙira bane ko mai hana enzymes na tsarin cytochrome P450. Rosuvastatin kawai shine rauni mai ƙarfi don aiwatar da waɗannan enzymes. Babu wata muhimmiyar hulɗar asibiti tsakanin ketoconazole (mai hana CYP 3A4 da CY P 2A6) ko fluconazole (mai hana CYP 3A4 da CYP 2A9) da rosuvastatin. Gudanarwa na lokaci guda na itraconazole (mai hana CY P3A4) da rosuvastatin suna ƙara AUC na ƙarshen ta hanyar 28%, wanda ba shi da mahimmanci a asibiti. Saboda haka, hulɗa da ke da alaƙa da metabolism na cytochrome P450 ba a sa ran.

Yawan abin sama da ya kamata
Idan kashi ya wuce, takamaiman magani bai ci gaba ba. Ana amfani da wakilai na Symptomatic da tallafi mai taimako. Idan kashi ya wuce, ya zama dole don sarrafa ayyukan hanta da abubuwan da ke cikin creatine phosphoskinase (CPK). Rashin ingancin maganin hemodialysis ba zai yiwu ba.

Fom ɗin saki
Allunan 10, 20, 40 MG. Akwai allunan guda 28 a cikin boro.

Yanayin ajiya
Adana a zazzabi da bai wuce 30 ° C. Ayi nesa da isar yara. An sake shi ta hanyar takardar sayan magani.

Abun ciki
Crestor 10 MG
Abubuwan da ke aiki: rosuvastatin 10 MG.

Crestor 20 MG
Abubuwan da ke aiki: rosuvastatin 20 MG.
Abubuwan marasa aiki: lactose monohydrate, microcrystalline cellulose, alli na foda, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, baƙin ƙarfe oxide (E 172), dioxide titanium, ruwa mai tsabta.

Crestor 40 MG
Abubuwan da ke aiki: rosuvastatin 40 MG.
Abubuwan marasa aiki: lactose monohydrate, microcrystalline cellulose, alli na foda, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, baƙin ƙarfe oxide (E 172), dioxide titanium, ruwa mai tsabta.

Kungiyar magunguna
Magungunan zuciya
Magungunan antisclerotic

Aiki mai aiki: Rosuvastatin

Zabi ne
Tare da haɓakar haɓakar haɓakar rashin lafiyar myopathy ko rhabdomyolysis, ya zama dole yin la'akari da rabo na amfanin magani da haɗarin haɗari, irin waɗannan marasa lafiya suna ƙarƙashin kulawa na likita. A cikin taron cewa matakin CPK ya tashi sosai (sau 5 ko sama da haka) koda kafin jiyya, bai kamata a ɗauki rosuvastatin ba. Eterayyade cretin phosphokinase don sarrafa yiwuwar haɓaka rhabdomyolysis ko myopathy bai dace ba don aiwatar da gaban wasu abubuwan da ake iya yiwuwa don haɓaka cikin CPK ko bayan matsanancin motsa jiki, tunda wannan na iya ba da gudummawa ga fassarar da ba ta dace ba game da sakamakon. Idan farkon abin da ke cikin murfin phosphokinase yana ƙaruwa sau 5 ko sama da haka, ƙuduri na gaba na enzyme a cikin ƙwayar jini dole ne ya zama ƙasa da kwanaki 5 (matsakaici - 7). Bai kamata ku fara jiyya tare da Crestor ba idan ƙuduri na biyu ya nuna babban matakin farko na ƙirƙirar phosphokinase (5 sau fiye da iyakar al'ada).
Crestor, kamar sauran inhibitors na HMG-CoA reductase, ya kamata a tsara shi tare da taka tsantsan ga marasa lafiya da ke da haɓakar haɓaka myopathy / rhabdomyolysis. Abubuwan haɗari don rhabdomyolysis ko myopathy na iya zama: hypothyroidism, renal failure, yanayin da ke haifar da karuwa a cikin ƙwayar plasma na rosuvastatin, shan barasa, shekaru sama da 70 shekaru, kasancewar cututtukan tsoka na gado a cikin dangi ko tarihin mutum, myotoxicity wanda aka tsokani ta hanyar amfani da wasu fibrates ko MMC-inhibitors Tarihin CoA reductase, amfani da fibrates.
Idan an tsara Krestor ga mara lafiya, za su zama wajibi a sanar da shi sakon gaggawa na gaggawa ga likitocin da ke halartar lamarin game da dukkan lamuran rauni na tsoka, rauni a jiki ko maɗauri, musamman idan suna tare da zazzabi da zazzaɓi. A cikin irin wannan marassa lafiyar, ana buƙatar ƙaddara matakin matakin creatine phosphokinase (CPK). Amincewa da Krestor ya kamata a dakatar idan abun da ke cikin CPK ya karu sosai (sau 5 ko sama da haka), ko kuma tare da tsananin raunin alamun ƙwayar tsoka wanda ke haifar da rashin jin daɗin yau da kullun har ma lokacin da abun ciki na creatine phosphokinase bai kai ƙaruwa 5 ba. Idan bayyanar cututtuka ta ɓace kuma abubuwan da ke cikin CPK sun sake komawa darajar ƙirar asali, la'akari da yiwuwar sake ɗaukar sauran HMG-CoA reductase ko Crestor inhibitors a cikin allurai ƙasa da waɗanda suka gabata. Irin wannan mara lafiya yana buƙatar kulawa da lafiya a hankali. Kulawa ta CPK ta yau da kullun idan babu alamun rhabdomyolysis ko myopathy ba shi da amfani
Babu alamun alamun karuwa a tasirin Crestor akan ƙwaƙwalwar kwarangwal yayin gwaji na asibiti tare da maganin kwantar da hankali. Kodayake, akwai rahotannin karuwa a cikin abin da ya faru na myopathy da myositis a cikin marasa lafiya waɗanda suka ɗauki sauran hanyoyin hanawa na HMG-CoA reductase tare da abubuwan fibrin acid (gami da amfani da kwayoyi kamar nicotinic acid, gemfibrozil, cyclosporine, inhibitors sunadarai, magungunan Azole antifungal da maganin macrolide). Gemfibrozil yana ƙara haɗarin cutar myopathy tare da haɗakar Crestor da wasu masu hana Htr-CoA reductase. Ba'a ba da shawarar don rubuta Krestor da gemfibrozil a lokaci guda. Wajibi ne a auna kimar amfanin fa'ida da kuma haɗarin da ke tattare da ambaton haɗarin niacin, fibrates da Crestor.
Gudanar da haɗin gwiwa tare da Krestor fibrates a cikin kashi 40 MG yana haɓaka.
Ba a ba da shawarar Krestor ga marasa lafiya da matsanancin yanayi ba (alal misali, tare da hypotension artery, trauma, sepsis), yayin babban aikin tiyata, da aka kira endocrine, na rayuwa ko cuta na cuta, kamar yadda kuma ba a kamu da cuta ba, tunda waɗannan yanayin na iya zama abubuwan haɗari don rhabdomyolysis / myopathy).
A cikin marasa lafiya waɗanda ke ɗaukar rosuvastatin a cikin allurai masu yawa (galibi a kashi 40 na MG / rana), an sami halayen sunadarin tubular proteinuria. Tubular proteinuria ya kasance na ɗan gajeren lokacin ne ko na wani lokaci a mafi yawan lokuta. Wannan furotin ba hujja bane na ci gaban cutar koda ko ci gaban wanda ake samu. Marasa lafiya da suke karɓar Krestor a kashi 40 na MG / rana, ana bada shawara don saka idanu kan sigogi na aiki koda da Krestor (gabaɗaya aikin jiyya).
Lokacin ɗaukar rosuvastatin, musamman a allurai na kimanin 20 mg / rana, an sami rahotannin sakamako daga ƙwayar kasusuwa, irin su ƙwayar tsoka, rhabdomyolysis, ko myopathy. Koyaya, tare da haɗakar ezetimibe da HMG-CoA reductase inhibitors, rhabdomyolysis ya ɓullo a cikin lokuta masu wuya.
Babu aminci da ingantaccen amfani da Krestor a cikin yara. A cikin ilimin yara, ƙwarewar yin amfani da rosulostatin yana iyakance ga adadi kaɗan na abubuwan lura (yara underan shekaru 8 da haihuwa kuma manya a gaban homozygous familial hypercholesterolemia). Sabili da haka, ba a ba da shawarar yin amfani da Krestor don magani a cikin ilimin yara.

Dukkanin bayanan an gabatar dasu ne don dalilai na bayanai kuma ba dalili bane don keɓaɓɓen magani ko maye gurbin magani.

Kuna iya jin daɗi a cikin yanayin rayuwar ku na yau da kullun, kuma bayan gwaji, koya game da hyperlipidemia - karuwar abun ciki na cholesterol da triglycerides a cikin jini.Cutar asymptomatic tana ƙara haɗarin haɗarin filayen atherosclerotic - abubuwanda ke haifar da bugun zuciya da bugun jini.

Krestor, ingantaccen magani na ƙarshe wanda aka tsara don daidaita al'ada metabolism, zai taimaka hana haɗari mai haɗari.

Hanyar magunguna

Crestor magani ne na rage rage kiba don inganta da kuma maganin atherosclerosis. Rosuvastatin, babban sinadaran aiki, yana da tasirin hypocholesterolemic da tasirin hypoliplera.

Krestor yana hana HMG-CoA reductase, enzyme wanda ke kula da samar da mevalonate, ƙwayar cholesterol. Rosuvastatin yana aiki a cikin hanta - ɗayan manyan gabobin ƙwaƙwalwa.

Statin yana rage adadin lipoproteins tare da ƙarancin girma da ƙima ta hanayar haɗin aikin su, tare da haɓaka ƙarin HDL don haɓaka da catabolism na LDL. Sakamakon haka, matakin adadin kuzarin, LDL da triglycerides ya ragu. A lokaci guda, maida hankali ne akan HDL.

Rosuvastatin yana da tasiri ga hypercholesterolemia a hade tare ko ba tare da hypertriglyceridemia ba, ga marasa lafiya na kowane jinsi, shekaru da tsere.

Sakamakon amfani da Krestor, yin hukunci ta hanyar martani daga mahalarta bincike, ana lura da shi a ƙarshen makon farko na hanya, amma ana iya ganin sakamako mafi girma (sama da 90%) kawai bayan makonni 2-4 na amfani na yau da kullun.

Ba kamar wasu analogues ba, Krestor yana da ƙananan tasirin mummunan sakamako akan hanta. Amfani dashi a hade tare da karancin abincin cholesterol da sauran magunguna wadanda ke rage cholesterol.

Me likitoci da marasa lafiya suke tunani game da Crestor

Game da Krestor, sake dubawar likitoci da marasa lafiya sun zo daidai: magani yana da tasiri, an yarda da shi sosai. Likitoci sun lura da babban tushe na shaida da kuma kwarewar mutum game da nasarar yin amfani da rosuvastatin.

Dovgopolov I.K., likitan zuciya, dan takarar kimiyyar likitanci Na tsawon wata daya ko biyu, ban yi amfani da Krestor ba ko maye gurbin analogues, har ma don rigakafin. Tabbas zaka iya tsabtace tasoshin kuma karesu daga kwandon kwalliya a cikin shekaru biyu, kuma wannan shine iyakar adadin (40 mg / day).
Idan kasafin kuɗi ya ba da izini, zai fi kyau siyan magani na ainihi. Tsarin asali na rosuvastatin shine Krestor, a gare shi cewa an gudanar da gwaje-gwaje tare da kimanta mace-mace daga cututtukan zuciya. Game da ilmin halitta, babu irin wannan bayanan, amma ana buƙatar analog mai inganci don inganta bayanan furotin, kodayake ba haka bane. Dole ne in ce gumaka ba a ɗauka don rage LDL ba, amma don hana bugun jini da bugun zuciya. Dole ne a sha magungunan da za su iya tsawaita rayuwa akai-akai.

Korolenko V.N., likitan fata. Krestor da sauri yana mayar da lipid metabolism koda a allurai low. Gaskiyar shaidar asalin magani ta kasance mai ƙarfi, akwai ƙananan sakamako masu illa fiye da sauran mutummutum, don haka zan iya tsara shi cikin aminci har ma ga marasa lafiya da cututtukan haɗin gwiwa kamar su mellitus ko familial hypercholesterolemia. Farashin Krestor, ba shakka, yana da ban sha'awa, amma watakila wannan shine kawai ɓarnarsa, musamman tunda magani na wannan matakin bazai zama mai arha ba.

Marina, Voskresensk. Krestor ya fi tsada sau da yawa fiye da takwarorinsa, don don adana kuɗi Ina da sayan babban kunshin, amma don kaina ban ga wani madadin ba. Na kasance fiye da shekara guda ina ɗaukar Statin, don haka in yi hukunci game da ingancinsa. Likitoci suna farin ciki da bayanin martaba na Ya yi imanin cewa Krestor shine mafi kyawun maganin wannan rukunin. Ban lura da wata illa ba.

Oleg, Irkutsk. Rashin bugun zuciyata ya kama ni da mamaki kuma ya sa na yi tunani game da lafiyata. Ya tafi wurin motsa jiki, yana ƙoƙarin daina shan sigari. Likita ya ba da umarnin rage cin abinci da Crestor. Ina sha kawai watanni biyu, ban sani ba - daga kwayoyi ko azuzuwan tare da mai horo, amma yanzu cholesterol ya kusan al'ada - 5.8. Ba na son dogaro da kwayoyi a duk tsawon rayuwata, don haka sai na yi ƙoƙarin kula da sabuwar hanyar rayuwa a gare ni.

Kuna iya koya game da kwarewar Amurka game da amfani da Krestor daga bidiyon "Magunguna don Mutane Masu Lafiya".

Sayan magunguna na Krestor, wanda ana wakiltar analogues a cikin cibiyar sadarwa ta kantin magani, ya zama dole don rage cholesterol na jini. Tasirin warkewa zai zama sananne bayan kwanaki 7 daga fara gudanarwa. A cikin mako mai zuwa, ƙwayar ta kusan sau 2 tana rage haɗarin cholesterol mai haɗari. Saboda yanayi daban-daban, ana iya amfani da magani na yau da kullun, a wannan yanayin, ana amfani da jigon (analog).

Babban arsenal na warkewa jamiái

Kafin rubuta kowane magani, kuna buƙatar gudanar da bincike. Manufarta ita ce ƙayyade matsayin ƙwarewar jiki. Idan wata buƙatacciyar bukata ta taso, ɗayan magungunan masu zuwa na iya maye gurbin samfurin na asali:

Mai haƙuri yana da damar zaɓi zaɓin analogues masu arha waɗanda ba su da ƙima a cikin alamomin su ga babban magani. Ya kamata a tuna cewa sashi da lokacin amfani ne kawai da likitan likita ya dogara da dalilai na asibiti. Waɗannan sun haɗa da yin rigakafi da magani na atherosclerosis da cholesterol hawan jini.

Maganin da aka zaba tare da daidaiton kayan ado yana taimakawa don samun sakamako mai kyau. Dole ne likitan likita ya ƙayyade yawan maganin tare da kulawa musamman lokacin da mai haƙuri ya ɗan taɓa bugun jini ko bugun zuciya. Idan mutum ya kamu da cutar hypercholesterolemia - ana canza kwayar cutar kwayar halittar jini, to lallai ya yi amfani da hanyoyin kwantar da hankali.

Magunguna na asali da waɗanda suke maye gurbinsu galibi ana wajabta su ne a matsayin abinci. Misali, likita ya bada shawarar rage girman jiki. A wannan yanayin, zaku iya amfani da takwaran na Rasha. Muna magana ne game da miyagun ƙwayoyi Martinil, Ariescor da Simvastin. Amincewa mai kama da wannan ita ce cikakke lokacin da aka gano mara lafiyar da kamuwa da cutar siga ta farko.

An zabi sashi don kada rage yawan kwalasta ba ya haifar da sakamako masu illa.

Siffofin amfani da miyagun ƙwayoyi

Cututtukan hanta da kodan sune manyan abubuwanda ake buƙatar la’akari da su domin hanzarta tsarin warkarwa. Saboda gaskiyar cewa analogues ya ƙunshi abubuwa waɗanda a cikin wani yanayi yana shafar sel na ƙwayar jini, dole ne likita ya bincika sakamakon sau da yawa. A gefe guda, ya zama dole don daidaita ayyukan jijiyoyin jini da wuri-wuri. Duk lokacin da suka kara zama gairaye da kananan bargogin cholesterol, to kuwa wahalar da jini itace tafiya cikin jiki.

A gefe guda, kuna buƙatar yin la'akari da tasirin hanta. Idan an lura da hana wannan hanya, ana bada shawara a zaɓi ƙaramin matakin da aka yarda da shi - ba fiye da 25 g na kayan ba a lokacin rana. Likita a duk tsawon lokacin kulawa yana lura da lafiyar mai haƙuri. Irin wannan yanayin zai kasance da amfani idan mai haƙuri yana da matsala a cikin kodan.

Binciken farko zai taimaka ba cutarwa ba. Dangane da sakamakon da aka samo, an zana ƙarshe game da yiwuwar amfani da miyagun ƙwayoyi. Daga cikin sauran abubuwan haɗari, likitoci sun bambanta shekarun mai haƙuri, kasancewar cututtukan cututtukan fata, magunguna da aka tsara a baya da kuma halaye da dama na mutum.

Kariya

Kafin fara karatun warkewa, likita dole ne ya bincika ko analog ko samfurin na gaba lafiyayyen mai haƙuri ne. Ba da shawarar sanya shi ga masu juna biyu da masu shayarwa ba. Zai fi kyau zaɓar analogues na Krestor tare da rashin hankali, aikin hanta mai rauni, idan mai haƙuri yana ƙasa da shekara 18.

Yin amfani da analog ko babban magani tare da cholesterol koyaushe ba shi da aminci. Ko da likitan likita ya lura da duk matakan tsaro, akwai yuwuwar illarsa:

• bayyanar cutar sankarau
• migraine da ciwon kai
• yawan tashin zuciya
• jin zafi na ciki
• zawo
• maƙarƙashiya
• tsananin farin ciki
• cututtukan mahaifa
• kurji da itching
• karancin numfashi.

An bada izinin amfani da babban magunguna da analogues ne kawai bayan ziyarar ofishin likita. Likita zai jagoranci gwaji kuma ya wajabta gwaje-gwajen da suka kamata. Dangane da bayanan da aka tattara, ana yin ƙimar kiwon lafiya. Bayan wannan, an ƙaddara matakin warkewa da tsawon lokacin gudanarwa. Daidai mafi haƙuri yana cika shawarwarin da aka karɓa, cikin sauri zai dawo.