Vasotens® (Vasotens®)

Musamman mai karɓar karɓar angiotensin II (ƙirar AT1)
Shiri: VAZOTENZ®

Aiki mai guba na miyagun ƙwayoyi: losartan
Lullukin ATX: C09CA01
KFG: Angiotensin II mai karɓar baƙi
Lambar yin rijista: LS-002340
Ranar rajista: 12/08/06
Mai mallaka reg. acc.: ACTAVIS hf.

Fitar saki na Vazotens, shirya magunguna da abun da ke ciki.

Allunan da aka sassaka masu launin fari, biconvex, masu alama "3L" a gefe guda, tare da haɗari a bangarorin biyu da haɗarin gefe. Shafin 1 losartan potassium 50 MG
Fitattun bayanai: mannitol, celclose microcrystalline, sodium croscarmellose, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 inji mai kwakwalwa - blister (2) - fakitoci na kwali.
Allunan da aka sassaka farare sune m, biconvex, tare da nada “4L” a gefe guda. Shafin 1 losartan potassium 100 MG
Fitattun bayanai: mannitol, celclose microcrystalline, sodium croscarmellose, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 inji mai kwakwalwa - blister (2) - fakitoci na kwali.

Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Abun ciki da nau'i na saki

a cikin murfin leda 7 inji mai kwakwalwa., a cikin fakitin kwali 2 mai murhunan wuta.

Formaddamar da tsari da abun da ke ciki

Sigar ta hanyar - allunan da aka rufe:

• 12.5 mg: zagaye, convex a garesu, fararen fata, aka sanya alama "1L" a gefe guda,
• 25 MG: zagaye, convex a garesu, fararen fata, aka sanya alama "2L" a gefe guda,
• 50 MG: zagaye, convex a garesu, fararen fata, tare da haɗari a gefe da haɗari a ɓangarorin biyu, masu alama da "3" da "L" a garesu na haɗarin,
• 100 MG: m, convex a garesu, fari, tare da daraja a gefe guda da kuma alamar “4L” a ɗayan, tare da haɗarin gefen.

Shigowar allunan: 7 inji mai kwakwalwa. a cikin kunshin bakin ciki, a cikin kwali na kwali na 2 ko 4 na blisters, guda 10. a cikin kunshin bakin ciki, a cikin kwali na kwali na 1 ko 3 blisters, pcs 14. a cikin lamunin bakin ciki, a cikin kwali na 1 ko 2 bugun ruwa. Kowane ɗayan kunshin ya ƙunshi umarnin don amfani da vazotenza.

Abubuwan da ke aiki: potassium losartan, a cikin kwamfutar hannu 1 - 12.5 MG, 25 MG, 50 MG ko 100 MG.

Abubuwan taimako: microcrystalline cellulose, hypromellose 6, povidone K-30, croscarmellose sodium, mannitol, magnesium stearate, propylene glycol, talc, titanium dioxide (E171).

Bayanin sigar sashi

Allunan 50m: allunan biconvex zagaye, fararen fata, mai rufi, tare da zane a gefe guda "3L", tare da haɗari a bangarorin biyu da haɗarin gefe.

Allunan 100m: m biconvex allunan, fari, mai rufi, tare da zane a gefe guda "4L".

Pharmacodynamics

Losartan takamaiman mai adawa ne na masu karɓar angiotensin II, nasa ne da ƙimar AT₁. Kinase II (enzyme bradykinin) baya hanawa.

Babban tasirin losartan:

• raguwa a cikin duka jijiyoyin bugun jini, maida hankali na aldosterone da adrenaline a cikin jini, hawan jini, matsa lamba a cikin jijiyoyin kumburi,
• bayan saukarwa
• sakamako diuretic
• hana haɓakar hauhawar jini,
• increasedara yawan haƙuri da haƙuri yayin raunin zuciya.

Vasotens yana haifar da sakamako mai ban tsoro bayan kashi ɗaya (wanda aka nuna a matsayin raguwa a systolic da matsa lamba na diastolic), yana kaiwa matsakaici bayan sa'o'i 6, sannan tasirin a hankali ya ragu sama da awanni 24.

Matsakaicin sakamako mai narkewa na cutar huhu yana tasowa makonni 3-6 bayan farawar gudanarwa.

Pharmacokinetics

Losartan yana ɗaukar hanzari daga ƙwayar gastrointestinal. Kimar bioa kusan kashi 33%. T_max (lokaci don isa a mayar da hankali da abu) - minti 60.

Losartan yana yin tasirin sakamako na farko ta hanyar hanta, metabolism yana faruwa ta hanyar carbonxylation tare da halartar CYP2C9 isoenzyme, kuma an kafa metabolite mai aiki. T_max metabolite mai aiki - sa'o'i 3-4, digiri na ɗaukar nauyin garkuwar jini na jini - 99%.

T_1/2 (rabin-rayuwa) na wani abu yana cikin kewayon daga awa 1.5 zuwa awa 2, babban metabolite din shine 6-9. Kusan 35% na kashi an fesa shi a cikin fitsari, ta hanjin hancin - kusan 60%.

Tare da cirrhosis na hanta, ƙwayar plasma na losartan yana ƙaruwa sosai.

Vazotens, umarnin don amfani: hanyar da sashi

Ya kamata a sha allunan Vazotens a baki sau 1 a rana guda (ba tare da la'akari da maganin da aka gindaya ba). Lokacin abinci ba shi da mahimmanci.

Daidaitaccen tsarin magunguna na kamuwa da cuta:

• hauhawar jijiyoyin jini: matsakaiciyar maganin warkewa shine 50 MG, don cimma sakamako mafi girma, yana yiwuwa a ƙara kashi zuwa 100 MG, idan ya cancanta, ana iya rarraba kashi na yau da kullun zuwa allurai 2. Kashi na farko ga marasa lafiya da suke karbar allurai na diuretics shine 25 MG.
• bugun zuciya: kashi na farko shine 12.5 MG, sannan an kara shi a tsakanin tsawan 1 mako, da farko har zuwa 25 MG, sannan zuwa 50 MG. Matsakaicin aikin tabbatarwa shine 50 MG.

A ƙananan allurai, ana wajabta vasotens ga marasa lafiya waɗanda ke fama da raunin hanta, gami da cirrhosis.

Side effects

A mafi yawancin halayen, vasotens an yarda da su sosai, halayen da ba su da kyau suna da kwanciyar hankali a cikin yanayi kuma basa buƙatar dakatar da ilimin.

Matsaloli masu iya haifar da sakamako:

• daga tsarin zuciya: jijiyoyin jini (orthostatic hypotension (dogara-kashi)), bugun zuciya, arrhythmias, bradycardia, tachycardia, angina pectoris,
• daga tsarin juyayi: sau da yawa (≥ 1%) - tsananin ciki, gajiya, asthenia, rashin bacci, ciwon kai, da wuya (

Haihuwa da lactation

Babu bayanai game da amfani da losartan yayin daukar ciki. Koyaya, sananne ne cewa magungunan da ke shafar tsarin renin-angiotensin kai tsaye, lokacin da aka yi amfani da su a cikin na biyu da na uku na ciki, na iya haifar da lahani na haɓaka ko ma mutuwar tayi. Sabili da haka, idan ciki ya faru, ya kamata a dakatar da Vazotenza ® nan da nan.

Lokacin da aka wajabta ta yayin shayarwa, ya kamata a yanke shawara don dakatar da shayarwa ko kuma dakatar da jiyya tare da Vazotens ®.

Haɗa kai

Zai yiwu a ƙayyade tare da wasu jami'in antihypertensive.

Babu wata ma'amala mai mahimmanci ta hanyar asibiti tare da hydrochlorothiazide, digoxin, anticoagulants kai tsaye, cimetidine, phenobarbital.

A cikin marasa lafiya masu fama da rashin ruwa (lokacin jiyya tare da manyan allurai na diuretics), raguwar alama a cikin karfin jini na iya faruwa.

Haɓaka (tare da juna) sakamakon wasu magungunan rigakafi (diuretics, beta-blockers, sympatholytics).

Theara yawan haɗarin hyperkalemia lokacin da aka yi amfani dashi tare da daskararren ƙwayoyin potassium da shirye-shiryen potassium.

Sashi da gudanarwa

A ciki ba tare da la'akari da abincin ba. Maimaitawa da yawa - sau 1 a rana.

Tare da hauhawar jini, matsakaicin yawan yau da kullun shine 50 MG. A wasu halaye, don cimma sakamako mafi girma, ana ƙaruwa kashi zuwa 100 MG cikin allurai 2 ko sau 1 a rana.

Matsayi na farko ga marasa lafiya da raunin zuciya shine 12.5 MG sau ɗaya a rana. A matsayinka na mai mulki, ana karuwa da kashi tare da tazara ta mako (i.e. 12.5, 25 da 50 mg / day) zuwa matsakaiciyar kulawa da 50 mg sau ɗaya a rana, gwargwadon haƙuri da haƙuri ga miyagun ƙwayoyi.

Lokacin da yake ba da magani ga masu haƙuri da ke karɓar diuretics a cikin allurai masu yawa, kashi na farko na miyagun ƙwayoyi na Vazotens ® ya kamata a rage zuwa 25 MG sau ɗaya a rana.

Ya kamata a ba marasa lafiya da ke fama da cutar hanta ƙananan ƙwayoyi na Vazotenza ®.

A cikin tsofaffi marasa lafiya, da kuma a cikin marasa lafiya da ke fama da rauni na aikin koda, ciki har da marasa lafiya akan dialysis, babu buƙatar daidaita kashi na farko.

Amfani da yara

Ba a tabbatar da aminci da ingancin maganin a cikin yara ba.

Umarni na musamman

Wajibi ne a gyara bushewar ruwa kafin a rubuta magungunan Vazotens ® ko kuma a fara jiyya tare da amfani da miyagun ƙwayoyi a cikin ƙananan kashi.

Magunguna waɗanda ke shafar tsarin renin-angiotensin na iya haɓaka urea da jini a cikin marasa lafiya da ke fama da jijiyoyin koda ko na koda.

A lokacin kulawa, ya kamata a sa ido kan abubuwan da ke cikin potassium a cikin jini a kai a kai, musamman ma a cikin tsofaffi marassa lafiya, tare da nakasa aikin na koda.

Rayuwar shiryayye na miyagun ƙwayoyi Vazotens ®

Allunan mai rufi 12.5 MG - 3 shekaru.

Allunan mai rufi 12.5 MG - 3 shekaru.

Allunan mai rufi 25 MG - 3 shekaru.

Allunan mai rufi 25 MG - 3 shekaru.

Allunan mai rufi 50 MG - 3 shekaru.

Allunan mai rufi 50 MG - 3 shekaru.

Allunan mai rufi 100 MG - 3 shekaru.

Allunan mai rufi 100 MG - 3 shekaru.

Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Maganin magunguna na vasotens

Musamman mai karɓar angiotensin II mai karɓar antagonist (ƙarancin AT1). Ya hana kinase II, enzyme wanda ke rushe bradykinin. Yana rage OPSS, maida hankali a cikin jinin adrenaline da aldosterone, hawan jini, matsin lamba a cikin jijiyoyin huhun. Yana rage bayan fitarwa, yana da tasirin diuretic. Yana hana haɓakar hauhawar myocardial, yana ƙaruwa da haƙurin motsa jiki a cikin marasa lafiya tare da raunin zuciya.
Bayan kashi ɗaya, tasirin hypotensive (systolic da diastolic pressure saukar jini) ya kai matsakaici bayan sa'o'i 6, sannan sannu a hankali ya rage a cikin sa'o'i 24.
Ana samun sakamako mafi girman hypotensive makonni 3-6 bayan fara maganin.

Vazotens: farashin a cikin kantin magani na kan layi

Vazotens 12.5 MG mai kwakwalwa Allunan mai kwakwalwa 30 inji mai kwakwalwa.

Vazotens 50 MG kwalabe mai kwakwalwa 30 inji mai kwakwalwa.

VAZOTENZ 50mg 30 inji mai kwakwalwa. Allunan mai rufi

Shafin Vazotens. PO 50mg n30

Shafin Vazotens. PO 100mg n30

Vazotens 100 MG kwalabe mai ɗaukar hoto 30 inji mai kwakwalwa.

VAZOTENZ 100mg 30 inji mai kwakwalwa. Allunan mai rufi

VAZOTENZ N 100mg + 25mg 30 inji mai kwakwalwa. Allunan mai rufe fim

Ilimi: Jami'ar Kiwon lafiya ta jihar Rostov, kwararrun "General Medicine".

Bayanai game da miyagun ƙwayoyi an samar da su duka, an bayar da su don dalilai na bayanai kuma baya maye gurbin umarnin hukuma. Kai magani yana da haɗari ga lafiya!

Domin faɗi har ma da mafi guntu kuma mafi sauƙaƙan kalmomi, muna amfani da tsokoki 72.

Mutanen da ake amfani da su don karin kumallo na yau da kullun ba su da kiba.

Mutumin da yake da ilimi bashi da saukin kamuwa da cututtukan kwakwalwa. Aikin mai hankali yakan bada gudummawa wajen samar da ƙarin ƙwayar cuta don rama marasa lafiya.

Likitocin hakora sun bayyana ne kwanan nan. A cikin ƙarni na 19, aikin maikatan gashi ne don fitar da hakoran da ke da lafiya.

Idan hanta ta daina aiki, mutuwa zata faru tsakanin kwana guda.

A cewar masana kimiyya da yawa, hadadden bitamin ba su da amfani ga mutane.

A lokacin rayuwa, matsakaicin mutum ya samar da kasa da ruwa biyu na yau.

Dangane da kididdigar, a ranakun Litinin, hadarin raunin baya yana ƙaruwa da 25%, da kuma haɗarin bugun zuciya - da kashi 33%. Yi hankali.

A cewar binciken na WHO, tattaunawa ta rabin sa'a a kowace rana ta wayar hannu na kara yiwuwar cizon ciwan kwakwalwa da kashi 40%.

Idan kayi murmushi sau biyu kawai a rana, zaku iya rage karfin jini da rage hadarin bugun zuciya da bugun jini.

Matsakaicin rayuwar lefties ya kasa da nisanci.

Akwai syndromes na likita masu ban sha'awa, irin su sha'awar abubuwa. A cikin ciki na haƙuri ɗaya da ke fama da wannan matsala, an gano abubuwa 2500 na ƙasashen waje.

Mabuɗin cakulan duhu huɗu sun ƙunshi adadin kuzari ɗari biyu. Don haka idan ba kwa son samun lafiya, zai fi kyau kada ku ci fiye da lobules biyu a rana.

Aikin da mutum baya so yafi cutarwa ga kwakwalwarsa fiye da rashin aiki kwata-kwata.

Kasusuwa na mutum sau huɗu sun fi ƙarfin ƙarfi.

Yankin farko na fure yana zuwa ƙarshe, amma za a maye gurbin bishiyoyi da ciyawa daga farkon watan Yuni, wanda zai rikitar da masu rashin lafiyar.

Sashi da hanyar gudanar da magani.

Ana ɗaukar miyagun ƙwayoyi a baka, ba tare da la'akari da abincin ba, yawan lokacin gudanarwa - 1 lokaci / rana.
Tare da hauhawar jini, matsakaicin yawan yau da kullun shine 50 MG. A wasu halaye, don cimma sakamako mafi girma, ana ƙaruwa kashi zuwa 100 MG a cikin allurai 2 ko 1 lokaci / rana.
Lokacin da yake ba da magani ga masu haƙuri da ke karɓar diuretics a cikin allurai masu yawa, kashi na farko na miyagun ƙwayoyi ya kamata ya rage zuwa 25 MG 1 lokaci / rana.
Maganar farko ga marasa lafiya da raunin zuciya shine 12.5 mg 1 lokaci / rana. A matsayinka na mai mulkin, kashi yana ƙaruwa tare da tazara ta mako (i.e. 12.5 mg / rana, 25 mg / rana da 50 mg / day) zuwa matsakaiciyar kiyayewa na 50 mg 1 lokaci / rana, gwargwadon haƙuri.
Marasa lafiya da ke fama da rauni na hanta (gami da cirrhosis) ya kamata a sanya musu ƙananan allurai na vasotenz.
A cikin tsofaffi marasa lafiya, da kuma a cikin marasa lafiya da ke fama da rauni na aikin koda, ciki har da marasa lafiya akan dialysis, babu buƙatar daidaita kashi na farko.