Rosuvastatin da Atorvastatin: Wanne ya fi kyau?

Ana amfani da Rosuvastatin ko Atorvastatin don magance cututtukan da ke hade da hypercholesterolemia. Dukkanin magunguna suna daga cikin ingantattun magunguna don ragewan jini cholesterol (cholesterol). Lokacin amfani da shi daidai, a zahiri basa haifar da illa.

Halayen rosuvastatin

Rosuvastatin shine ingantaccen maganin cututtukan cututtukan dabbobi na 4 Kowane kwamfutar hannu ya ƙunshi daga 5 zuwa 40 MG na kayan aiki na rosuvastatin. Abun da ke tattare da abubuwan taimako shine wakilcin: colloidal silicon dioxide, lactose monohydrate, sitaci na masara ko masara, dyes.

Statins suna ba da gudummawa ga karuwa a cikin ayyukan masu karɓar ƙwayoyin lipoprotein marasa ƙarfi, wanda ke haifar da raguwar adadin su. A lokaci guda, matsakaicin matakin tasirin cholesterol yana raguwa kuma adadin adadin kuzarin mai yawa yana ƙaruwa. Tasirin warkewa yana farawa kimanin kwanaki 7 bayan farawar magani. Ana lura da mafi girman tasirin bayan kusan wata guda daga farkon hanya.

Wannan magani ana nuna shi da karancin bioavailability - kusan kashi 20%. Kusan duk adadin abubuwan da aka ɗauka na wannan sun ɗauka sunadarai zuwa ƙwayoyin plasma. An keɓe shi da feces canzawa. Lokacin rage matakan rosuvastatin a cikin jini da rabi shine awa 19. Yana ƙaruwa tare da nakasa mai aiki da hanta.

An nuna magungunan don lura da nau'ikan nau'ikan hypercholesterolemia a cikin marasa lafiya daga shekaru 10 da haihuwa. Ana bada shawarar wannan kayan aiki a matsayin ƙari ga ƙarancin abinci na cholesterol, lokacin da aka rage tasirin abincin abinci mai warkewa. Ana bada shawarar Rosuvastatin don asalin kwayoyin da ke tattare da yanayin maganin hyzycholesterolemia.

An nuna Rosuvastatin a matsayin wakili mai tasiri don hana wasu cututtukan zuciya a cikin mutane masu haɗari.

Ana gudanar da Rosuvastatin a baki. Kafin farawa likita, an tura mai haƙuri zuwa abinci tare da ƙarancin cholesterol. An zaɓi sashi yana la'akari da alamun mutum, halayen lafiyar lafiyar haƙuri. Farawa kashi - daga 5 MG. Gyara yawan adadin da aka ɗauka yana faruwa 4 makonni bayan fara magani (idan har ba shi da tasiri sosai).

• yana da shekaru mara lafiya har zuwa shekaru 18,
• mutane sama da 70 shekara
• marasa lafiya da cututtukan da yara, hanta,
• marasa lafiya da ke fama da cutar yoyopathies.

Ana ɗaukar magani tare da taka tsantsan idan mai haƙuri yana da ƙarin aiki na enzymes hanta.

Rosuvastatin yana haifar da waɗannan sakamako masu illa:

• ci gaban hauhawar jini,
• tsananin farin ciki
• ciwon ciki
• gajiya,
• ciwon kai
• maƙarƙashiya
• zafi a cikin gidajen abinci da tsokoki,
• karuwa da yawan furotin a cikin fitsari,
• halayen rashin lafiyan halayen
• da wuya, ci gaban nono.

Verarfin mummunan halayen da ake samu yayin rage ƙwayar cholesterol ya dogara da kashi. An sanya maganin a cikin:

• daidaitaccen haƙuri na aiki mai aiki ko kayan taimako na mutum guda ɗaya,
• cututtukan gado na tsokoki da tsokoki (ciki har da tarihin)
• gazawar thyroid
• na kullum mai shan giya
• mallakar tseren Mongoloid (a wasu mutane wannan maganin bai nuna aikin asibiti ba),
• mai rauni mai guba,
• ciki
• nono.

Alamar Atorvastatin

Atorvastatin shine ingantacciyar ƙwayar cuta na ƙarni na 3 na maganin cututtukan jini. Abun da ke ciki na allunan sun hada da sinadarin atorvastatin mai aiki daga 10 zuwa 80 MG. Componentsarin abubuwan da aka haɗa sun haɗa da lactose.

Atorvastatin a cikin allurai masu matsakaici sosai yana rage ayyukan enzymes waɗanda ke taimakawa ci gaban ƙarancin lipoproteins mai yawa. A lokaci guda, yawan ƙwayar cholesterol yana ƙaruwa.

Amfani da wannan kayan aikin yana taimakawa rage ƙarancin mace-mace daga cututtukan zuciya na zuciya, ciki har da infarction na zuciya.

Maganin yana rage yawan cututtukan zuciya da jijiyoyin jini.

Bayan gudanarwa na ciki, yana narkewa a cikin ƙwayar gastrointestinal na sa'o'i da yawa. Kasancewar abu mai aiki idan an sami damar gudanar da aiki na baka yana da ƙasa. Kusan duk adadin maganin da aka yi amfani da shi yana da alaƙa da sunadaran plasma. Don yin musayar a cikin kyallen hanta tare da kira na pharmacologically aiki metabolites.

An cire maganin a hanta. Rabin rayuwar miyagun ƙwayoyi yakai kimanin sa'o'i 14. Ba a cire shi ta hanyar dialysis. Tare da aikin hanta mai rauni, akwai ƙara haɓakawa a cikin tattarawar abu mai aiki a cikin jini.

Alamu don amfani:

• hadaddun jiyya na babban cholesterol a cikin jini,
• gaban abubuwan da ke tattare da hadarin don ci gaban cututtukan zuciya da cututtukan zuciya, ciwon sukari,
• gaban wani tarihi na pathologies na zuciya da jini,
• ciwon sukari
• kasancewar yara a cikin abubuwan da suka faru na tasirin cholesterol metabolism dangane da heterozygous hereditary hypercholesterolemia.

Kafin shan wannan magani, an tura mai haƙuri zuwa abincin da ya dace tare da ƙarancin cholesterol. Mafi ƙarancin maganin yau da kullun shine 10 MG, wanda aka dauka 1 lokaci ɗaya kowace rana, ba tare da la'akari da lokacin cin abinci ba. Tsawon lokacin magani, yiwuwar karuwar sashi ne likita ke ƙididdige shi, yana nazarin yanayin kuzarin yanayin haƙuri.

Matsakaicin kashi na manya shine 80 mg na atorvastatin. An tsara yara daga shekaru 10 basu wuce 20 MG na wannan magani ba. Ana amfani da wannan kaso ɗaya ɗin a cikin lura da marasa lafiya da cututtukan hanta da koda. Mutanen da suka wuce 60 ba su buƙatar canjin sashi.

Abubuwan sakamako masu illa da contraindications iri ɗaya ne a cikin Rosuvastatin. Wani lokacin tashin hankali yana rikicewa a cikin maza. A cikin yara, wadannan sakamako masu illa suna yiwuwa:

• raguwar platelet,
• nauyi
• tashin zuciya da kuma wani lokacin amai
• kumburin hanta
• stagnation na bile
• katsewar tendons da jijiyoyi,
• ci gaban edema.

Kwatanta Miyagun Kwayoyi

Yin kwatancen waɗannan kayan aikin yana taimaka wajan zaɓi hanya mafi inganci don kula da kwayar cutar hawan jini.

Wadannan magungunan suna da alaƙa da statins. Suna da asali na roba. Rosuvastatin da Atorvastatin suna da irin wannan tsari na aiki, sakamako masu illa da contraindications, alamomi.

Dukkanin magunguna guda biyu sun toshe HMG-CoA reductase, wanda ke da alhakin samar da cholesterol. Wannan aikin ya kuma shafi yanayin mai haƙuri.

Menene bambance-bambance?

Bambanci tsakanin waɗannan hanyoyin shi ne cewa Atorvastatin nasa ne na mutum-mutumi na 3, kuma Rosuvastatin - na ƙarshe, ƙarni 4.

Bambanci tsakanin su shi ne cewa rosuvastatin yana buƙatar mafi ƙarancin kashi don samar da tasirin warkewar da ake bukata.

Don haka, sakamako masu illa daga jiyya na statin ba su da yawa.

Shin zai yiwu canzawa daga Atorvastatin zuwa Rosuvastatin?

An haramta canza magunguna ba tare da izinin likita na gaba daya ba. Kodayake magungunan biyu suna da alaƙa da statins, tasirin su ya bambanta.

Likita ya yanke shawara game da canjin magani a mafi yawan lokuta tare da rashin jituwa ga kowane bangare. Tasirin magani baya canzawa.

Wanne ya fi kyau - rosuvastatin ko atorvastatin?

Nazarin asibiti ya nuna cewa shan rabin kashi na rosuvastatin yafi tasiri fiye da yawan atorvastatin. Matakan cholesterol na jini yayin daukar gumakan mutanen da suka gabata an rage su sosai.

Rosuvastatin (da analogues) mafi kyawun ƙaruwa mai yawa yana haifar da cholesterol, sabili da haka, yana da fa'idodi lokacin da aka tsara. Wannan kuma yana tabbatar da ra'ayin masu amfani da shi.

Rosuvastatin fara aiki da sauri. Zai fi kyau haƙuri da haƙuri da kuma haifar da ƙananan sakamako masu illa.

Ra'ayin likitoci

Aleksey, dan shekara 58, mai ilimin tauhidi, Moscow: “Lokacin da cholesterol ta fadi cikin jini don hana ci gaban mahaifa, na shawarci marassa lafiya su dauki Rosuvastatin. Magungunan suna da tasiri a asibiti kuma a lokaci guda suna haifar da mafi ƙarancin halayen m. Ina bayar da shawarar fara jiyya tare da kashi 5-10 MG. Bayan wata daya, cikin yanayin rashin wadatar wannan nau'in, Ina bayar da shawarar ƙara shi. "Marasa lafiya sun yi haƙuri da jiyya sosai kuma tare da ƙarancin abinci na cholesterol, babu sakamako masu illa."

Irina, mai shekara 50, therapist, Saratov: “Don hana haɓakar infarction na zuciya, atherosclerosis da bugun jini a cikin marasa lafiya da ke fama da matsalar ƙwayar cuta, na bayar da shawarar Atorvastatin a gare su. Ina ba ku shawara ku ɗauki mafi ƙarancin inganci da farko (Na zaɓe shi bisa ga sakamakon gwaje-gwaje na asibiti). Idan matakan cholesterol ba su raguwa bayan wata guda, kara kashi. Marasa lafiya sun yi haƙuri da jiyya sosai, raunin da ba kasafai ake samu ba. "

Binciken haƙuri game da Rosuvastine da Atorvastine

Irina, shekara 50, Tambov: “Matsalar ta fara hauhawa sau da yawa. Da ta juya ga likita, sai ta yi duk wasu gwaje-gwajen da suka kamata, wanda hakan ya nuna karuwar kwayar jini. Don rage nuna alama, likita ya ba da shawarar shan Rosuvastatin 10 MG, lokaci 1 a rana. Na lura da sakamakon farko bayan sati 2. Na ci gaba da shan wannan magani tsawon watanni 3, lafiyar ta ta inganta sosai. ”

Olga, mai shekara 45, Moscow: “Gwaje-gwajen jini na kwanan nan sun gano cewa ina da cholesterol a cikin jini. Don hana haɓakar atherosclerosis da cututtukan zuciya, likita ya ba da umarnin 20 mg atorvastatin. Ina shan wannan maganin da safe bayan cin abinci. Makonni 2 bayan fara magani, ta lura cewa maniyina ya ragu, gajiya ta tafi bayan aiki na zahiri. Bayan watanni 2 na jiyya, hawan jini ya ragu. Na bi abinci, na ƙi samfura tare da "cholesterol" mara kyau. "

Menene bambanci?

Atorvastatin da rosuvastatin sun bambanta:

• nau'in da sashi na abubuwa masu aiki (magani na farko ya ƙunshi alli atorvastatin, na biyu ya ƙunshi alli rosuvastatin),
• ƙimar sha daga abubuwan aiki masu aiki (Rosuvastatin yana tunawa da sauri),
• kawar da rabin rayuwar (magani na farko an keɓe shi da sauri, saboda haka yana buƙatar ɗaukar sau 2 a rana),
• metabolism na abu mai aiki (ana canza atorvastatin a cikin hanta kuma an cire shi tare da bile, rosuvastatin baya hade cikin hanyoyin rayuwa kuma yana barin jiki tare da feces).

Wanne ne mafi aminci?

Rosuvastatin har zuwa mafi karanci yana shafar aikin hanta da kodan, saboda haka ana ɗaukar shi mafi aminci. Kari akan haka, yana da rawar da ba ta da yawa sosai illa tasirin sakamako idan aka kwatanta da Atorvastatin.

Atorvastatin yana da rawar da zata iya haifar da tasirin sakamako fiye da rosuvastine.

Nasihun Mai haƙuri game da Rosuvastatin da Atorvastatin

Elena, dan shekara 58, Kaluga: “Wani bincike da aka yi ya nuna an sami hauhawar cholesterol. Likita ya ba da shawarar atorvastatin ko rosuvastine su zaɓi daga. Na yanke shawarar farawa da magani na farko, wanda ke da ƙananan farashi. Na sha kwayoyin hana daukar ciki har tsawon wata daya, magani yana hade da bayyanar fatar fatar fata da itching. Na juya zuwa Rosuvastatin, kuma waɗannan matsalolin sun ɓace. Yawan cholesterol a cikin jini ya koma al'ada kuma bai yi tsawan watanni shida ba. ”

Yin bita Atorvastatin da Rosuvastatin

Atorvastatin magani ne wanda ke da tasirin hypocholesterolemic. A yayin aikin ta hanyar jikin, mai hanawa yana sa ido kan ayyukan kwayoyin enzyme wadanda ke tsara hada kwayar mevalonic acid. Mevalonate tsari ne ga sterols da ake samu a cikin ƙarancin lipoproteins mai yawa.

Allunan statin Allunan ana amfani dasu wajen lura da ƙwayar cholesterol. A lokacin bayyanar atherosclerotic bayyananne, yin amfani da miyagun ƙwayoyi yana nuna sakamako mai kyau akan metabolism na lipid, rage yawan ƙwayoyin lipid na LDL, VLDL da triglycerides, waɗanda sune tushen tushen samuwar atherosclerotic neoplasms. Lokacin amfani da magani, raguwa a cikin ma'aunin cholesterol yana faruwa, ba tare da la'akari da etiology ba.

An wajabta magungunan Rosuvastatin da yawan ƙwayoyin ƙwayoyin LDL a cikin jini na jini. Magungunan yana cikin rukunin mutum-mutumi na ƙarni na ƙarshe (na ƙarshe), inda babban sinadaran aiki shine rosuvastatin. Magunguna na sababbin ƙarni tare da rosuvastatin sune mafi aminci ga jiki, kuma suna da babban tasiri na warkewa a cikin maganin hypercholesterolemia.

Ka'idar aiki da kwayoyi

Atorvastatin magani ne na lipophilic wanda ke narkewa kawai a cikin mai, kuma Rosuvastatin magani ne na hydrophilic wanda ke narkewa sosai a cikin jini da jini.

Ayyukan magunguna na zamani suna da tasiri sosai don da yawa ga marasa lafiya hanya guda na magani sun isa don rage jimlar cholesterol, ƙaramar LDL da VLDL, kazalika da triglycerides.

Hanyar aiwatar da gumakan

Dukkanin wakilai sune masu hana kwayoyin motsi na HMG-CoA. Choctase yana da alhakin haɗin mevalonic acid, wanda shine ɓangaren sterols kuma ɓangare ne na ƙwayar cholesterol. Molecules na cholesterol da triglycerides sune abubuwan da ke tattare da rashin wadataccen ƙwayoyin tsoka mai yawa, waɗanda suke haɗuwa yayin aiki a cikin sel hanta.

Tare da taimakon miyagun ƙwayoyi, ana rage adadin ƙwayar cholesterol, wanda ke haifar da masu karɓar LDL, wanda, lokacin da aka kunna shi, fara farautar ƙananan lipids mai ɗimbin yawa, kama su da jigilar su don zubar.

Godiya ga wannan aikin masu karɓa, raguwa mai yawa a cikin ƙananan ƙwayar cholesterol da haɓaka yawan ƙwayoyin jini a cikin jini yana faruwa, wanda ke hana haɓakar ƙwayoyin cuta.

Don kwatantawa, don fara aiwatar da aikin, Rosuvastatin baya buƙatar sauyawa a cikin ƙwayoyin hanta, kuma yana fara aiki da sauri, amma wannan magani baya tasiri akan rage ƙwayar triglycerides. Ba kamar maganin na ƙarshe ba, Atorvastatin an canza shi a cikin hanta, amma kuma yana da tasiri a rage ƙididdigar ƙwayoyin TG da ƙwayoyin cholesterol kyauta, saboda lipophilicity ɗin.

Manuniya da contraindications

Duk magungunan biyu suna da guda hanya a cikin lura da babban kwayar cholesterol, kuma, duk da bambance-bambance a cikin tsarin sunadarai, dukansu sune masu hana haɓaka HMG-CoA. Ya kamata a dauki allunan Statin tare da irin wannan rikice-rikice a cikin ma'aunin ƙwayar lipid:

• hypercholesterolemia of daban-daban etiologies (iyali da kuma gauraye)
• sabar, kamar,
• dyslipidemia,
• na system atherosclerosis.

Hakanan, magunguna an wajabta wa marasa lafiya a babban haɗarin haɓakar jijiyoyin jini da cututtukan zuciya:

• hauhawar jini
• angina pectoris
• zuciya ischemia
• ischemic da basur,
• infarction na zuciya.

Sanadin hypercholesterolemia cin zarafi ne a cikin ƙwayar lipid, wanda sau da yawa yakan faru ne sakamakon laifin mai haƙuri da kansa saboda hanyar rayuwa mara kyau.

Amincewa da statins zai taimaka hana ci gaban ilimin halittu, idan kun dauke su akai-akai don dalilan kariya a gaban wadannan abubuwan:

• Abinci mai cike da kayan mai,
• barasa da nicotine buri,
• juyayi juyayi da damuwa akai-akai,
• ba salon rayuwa mai aiki ba.

Contraindications na waɗannan magunguna biyu sun sha bamban (Table 2).

Umarnin don amfani

Dole ne a dauki Statins a baki tare da isasshen adadin ruwa. An haramta tauna kwamfutar hannu, saboda ana hade shi da membrane wanda ke narkewa a cikin hanjin. Kafin fara farawa da warkewa tare da mutum-mutumi na 3 da na 4, mai haƙuri dole ne ya bi tsarin abinci mai kyau, kuma rage cin abincin dole ya bi ta hanyar magani tare da magunguna.

Likita ya zaɓi zaɓi daban-daban da magani ga kowane mara lafiya, gwargwadon sakamakon gwaje-gwajen gwaje-gwaje, da kuma haƙurin mutum na mutum da cututtukan da ke haɗuwa da juna. Gyaran gyaran jiki, kazalika da maye gurbin maganin tare da wani magani, yana faruwa ne ba makonni biyu ba daga lokacin gudanarwa.

Tsarin Ayar Atorvastatin

Sigar farko don tsarin atherosclerosis na Rosuvastatin shine 5 MG, Atorvastatin 10 MG. Kuna buƙatar shan maganin 1 sau ɗaya kowace rana.

Sashi na yau da kullun a cikin maganin hypercholesterolemia na etiologies daban-daban:

• tare da hyzycholesterolemia na homozygous, sashi na Rosuvastatin shine 20 mg, Atorvastatin shine 40-80 mg,
• a cikin marasa lafiya da heterozygous hypercholesterolemia - 10-20 MG na Atorvastatin, sun kasu zuwa allurai safe da maraice.

Babban bambance-bambance da tasiri

Menene banbanci tsakanin rosuvastatin da atorvastatin? Bambanci tsakanin magunguna a bayyane yake a matakin ɗaukar ƙwayar su daga ƙananan hanji. Rosuvastatin baya buƙatar haɗawa da lokacin cin abinci, kuma Atorvastatin ya fara rasa kaddarorinsa idan kun ɗauki kwaya lokacin cin abincin dare ko kuma bayan shi.

Yin amfani da wasu kwayoyi kuma yana shafar wannan maganin, saboda canji zuwa ga tsari mara aiki yana faruwa tare da taimakon hanta enzymes na hanta. An cire magungunan daga jikin mutum tare da bile acid.

Rosuvastatin an cire shi da feces. Kar ku manta cewa don kowane magani na dogon lokaci, ana buƙatar albarkatun kuɗi. Atorvastatin sau 3 mai rahusa ne fiye da tsawan statin 4, don haka yana samuwa ga bangarori daban-daban na yawan jama'a. Farashin atorvastatin (10 MG) - 125 rubles., 20 MG - 150 rubles. Kudin Rosuvastatin (10 MG) - 360 rubles., 20 MG - 485 rubles.

Kowane magani zai yi aiki a jikin kowane mai haƙuri daban. Likita ya zaɓi magungunan daidai da shekaru, ilimin halayyar cuta, matakan ci gabanta kuma tare da alamun bayanin martaba na lipid. Atorvastatin ko Rosuvastatin lowers mummunan cholesterol kusan guda guda - a tsakanin 50-54%.

Tasirin Rosuvastatin yana daɗaɗawa kaɗan (a cikin 10%), sabili da haka, za'a iya amfani da waɗannan kaddarorin idan mai haƙuri yana da ƙananan ƙwayar cholesterol sama da 9-10 mmol / L. Hakanan, wannan magani a cikin mafi ƙarancin lokaci zai iya rage OXC, wanda ke rage yawan sakamako masu illa.

M halayen

Tasirin mummunar kwayoyi a jikin mutum shine babban abin da ke haifar da zaɓin maganin. Statins suna cikin waɗancan magungunan ne waɗanda idan an ɗauka da kyau, na iya haifar da mutuwa. Don hana sakamako masu illa, magungunan da likita ya umarta kada su wuce sosai kuma duk shawarwarin sa ya kamata a bi sosai.

Patientaya daga cikin haƙuri a cikin 100 yana da mummunan tasirin waɗannan:

• rashin bacci, haka kuma ƙwaƙwalwar ƙwaƙwalwa,
• jihar ta rashin hankali
• matsalolin jima'i.

A cikin mara lafiya ɗaya daga cikin 1000, irin wannan sakamakon na maganin yana iya faruwa:

• anemia
• ciwon kai da danshi da yawan karfi,
• paresthesia
• jijiyar wuya
• polyneuropathy
• anorexia
• maganin ciwon huhu
• narkewa na narkewa na ciki wanda ke haifar da jijiya a ciki da amai,
• haɓaka ko raguwa da glucose jini,
• daban-daban na hepatitis,
• rashin lafiyan rashes da matsanancin zafi,
• cututtukan mahaifa
• alopecia
• cutarwa da cutar sankara,
• asthenia
• angioedema,
• na tsarin vasculitis,
• amosanin gabbai
• polymyalgia wani nau'in rheumatic,
• thrombocytopenia
• eosinophilia
• hematuria da furotin,
• mai rauni sosai
• Namiji girma da rashin ƙarfi.

A cikin mawuyacin hali, rhabdomyolysis, hanta da gazawar koda na iya haɓaka.

Yin hulɗa tare da wasu magunguna da analogues

Ba za a iya hade Statins tare da duk magunguna. Wani lokacin hada magunguna guda biyu zai iya haifar da sakamako masu karfi:

1. Idan aka haɗu da cyclosporine, abin da ya faru na myopathy yana faruwa. Myopathy kuma yana faruwa yayin haɗuwa da wakilai na ƙwayoyin cuta na tetracycline, clarithromycin da ƙungiyoyin erythromycin.
2. Wani mummunan aiki na jikin mutum na iya faruwa lokacin ɗaukar mutum-mutumi da niacin.
3. Idan ka ɗauki Digoxin da statins, akwai karuwa a cikin tattarawar Digoxin da ƙirar jikin mutum. Ba'a ba da shawarar shan allunan sittin da ruwan 'ya'yan innabi ba. Ruwan 'ya'yan itace yana rage tasirin ƙwayar cuta na statin, amma yana haɓaka mummunan tasirinsa akan gabobin da tsarin a jikin mutum.
4. Amfani da daidaituwa na allunan Statin da antacids, da magnesium, rage maida hankali na statin a cikin sau 2. Idan kayi amfani da waɗannan kwayoyi tare da tazara na sa'o'i 2-3, to, rage mummunan tasirin zai ragu.
5. Lokacin haɗuwa da ƙwaƙwalwar ƙwayoyin Allunan da kariya na hanawa (HIV), to, AUC0-24 yana ƙaruwa sosai. Ga mutanen da ke kamuwa da kwayar cutar, kwayar cutar kwayar cutar kwayar cutar kwayar cutar kwayar cuta ce kuma tana da rikitarwa.

Atorvastatin yana da analogues 4, da Rozuvastatin - 12. Analogues na Rashanci na Atorvastatin-Teva, Atorvastatin SZ, Atorvastatin Canon suna da ƙananan farashi mai inganci. Kudin magunguna daga 110 zuwa 130 rubles.

Mafi ingancin analogues na rosuvastatin:

1. Rosucard magani ne na Czech wanda ke rage ingancin cholesterol na ɗan gajeren warkewar karatun.
2. Krestor magani ne na Amurka wanda shine ainihin asalin gumaka na tsararraki 4. Krestor - ya wuce dukkan karatun asibiti da kuma dakin gwaje-gwaje. Iyakar abin da ke jawowa a ciki shine farashin 850-1010 rubles.
3. Rosulip magani ne na kasar Hungary wanda yawanci ana ba shi maganin atherosclerosis don amfani na dogon lokaci.
4. Mertenil na likitancin Hungary - an wajabta shi don rage ƙarancin cholesterol da kuma rigakafin cututtukan zuciya.

Reviews game da mutummutumai koyaushe gauraye, saboda likitocin zuciya sunyi da'awar shan allunan Statin, kuma marasa lafiya, suna tsoron mummunan sakamako na jiki, ba su da amfani. Reviews daga likitoci da marasa lafiya zasu taimaka wajen tantance wanne yafi atorvastatin ko rosuvastatin:

Statins 3 da na 4 sun fi tasiri a lura da cututtukan cututtukan zuciya da na zuciya. Kyakkyawan zaɓi na kwayoyin hana daukar ciki likita ne kawai zai iya yin shi don magunguna su kawo iyakar fa'idodi tare da ƙarancin mummunan tasiri.

Menene statins?

Statins wani rukuni ne daban na magunguna na rage kiba (lipid-lowering) magunguna wadanda aka yi amfani da su don maganin hypercholesterolemia, i.e., matakan haɓaka matakan cholesterol (XC, Chol) a cikin jini, wanda ba za a iya rage ta yin amfani da hanyoyin da ba magani ba: ingantaccen salon rayuwa, wasanni da abinci.

Bayan babban sakamako, statins suna da wasu kaddarorin masu amfani waɗanda ke hana haɓakar rikice-rikice na zuciya da jijiyoyin jini:

• rike da ci gaba da samar da alluran atherosclerotic a cikin barga,
• bakin ciki ta hanyar rage platelet da tarawar erythrocyte,
• dakatar da kumburin endothelium da kuma dawo da aikinta,
• motsawar sinadarin nitric oxide, wajibi ne don shakatar jijiyoyin jini.

Yawanci, ana daukar statins tare da wuce haddi mai yawa na halayen cholesterol na al'ada - daga 6.5 mmol / l, duk da haka, idan mai haƙuri yana da abubuwan da ke haifar da haɓaka (nau'in ƙwayar halittar dyslipidemia, yanayin atherosclerosis da ke gudana, bugun zuciya ko tarihin bugun jini), to, ana tsara su a ƙananan ƙarancin - daga 5 8 mmol / L.

Abun haɗin gwiwa da ka'idodin aiki

Abun da ke cikin magungunan Atorvastatin (Atorvastatin) da Rosuvastatin (Rosuvastatin) sun hada da abubuwa na roba daga sababbin mutanen da suka gabata a jikin gishirin gishirin gwal - atorvastatin alli (III halittar) da kuma alli rosuvastatin (halittar IV) + abubuwan taimako, gami da hanyoyin samar da madara (lactose monohydrate) )

Ayyukan gumakan sun samo asali ne daga hanawar enzyme wanda ke da alhakin samar da cholesterol ta hanta (tushen kusan kashi 80% na abubuwan).

Hanyar aiwatar da magunguna guda biyu shine nufin ɗaukar maɓallin enzyme da ke da alhakin samar da cholesterol: ta hana (hanawa) haɗarin HMG-KoA reductase (HMG-CoA reductase) a cikin hanta, sun rage samar da acid mevalonic, wani abin da ke haifar da cholesterol na ciki (endogenous) cholesterol.

Bugu da ƙari, statins suna haɓaka samuwar masu karɓa waɗanda ke da alhakin jigilar ƙananan lipoproteins (LDL, LDL), musamman ƙarancin yawa (VLDL, VLDL) da triglycerides (TG, TG) da baya ga hanta don zubarwa, wanda ke haifar da raguwa mai kaifi a cikin mummunan "ɓarkewar ƙwayoyin cholesterol a cikin jini jini.

Ingancin sabon ƙarni na statins shine cewa ba su shafi metabolism metabolism, i.e., Atorvastatin da Rosuvastatin kawai dan ƙara haɓakar glucose, wanda ke ba da damar mutane har da nau'in-insulin-dogara da nau'in ciwon sukari na II don ɗaukarsu.

Atorvastatin ko Rosuvastatin: Wanne ya fi kyau?

Kowane tsari na gaba na ƙwayar magunguna mai aiki yana haifar da bayyanar sauran halayen magunguna a ciki, bi da bi, Rosuvastatin na gaba ya bambanta da Atorvastatin a cikin sababbin halaye waɗanda ke sa kwayoyi suka dogara da shi mafi inganci da aminci.

Kwatanta Atorvastatin da Rosuvastastinn (tebur):

Yin amfani da Atorvastatin da Rosuvastatin a allurai matsakaici daidai suke rage matakin “mummunan” cholesterol - ta hanyar 48-54% da 52-63%, sabili da haka, zaɓin ƙarshe na miyagun ƙwayoyi a kowane yanayi yana dogara ne akan halayen mutum na jikin mai haƙuri:

• jinsi, shekara, g hy ada da kuma iskanci ga abun,
• narkewa da kuma cututtukan tsarin urinary,
• magunguna da aka ɗauka a layi daya, abinci da salon rayuwa,
• sakamakon bincike da kayan aiki.

Rosuvastatin ya fi dacewa don magance cututtukan hypercholesterolemia a cikin mutanen da ke fama da hanta da matsalolin cututtukan fata. Ba kamar gumakan da suka gabata ba, baya buƙatar juyawa, amma nan da nan ya shiga cikin jini. Hakanan an fitar dashi galibi ta hanjin ciki, wanda ke rage nauyin aiki akan wadannan gabobin.

Idan mutum yana da ƙwayar cholesterol yana da kiba sosai, to ya kamata a zaɓi atorvastatin. Saboda yawan kitsewar kitsersa, yana cikin aiki sosai cikin rushewar lipids mai sauki kuma yana hana tuban cholesterol daga kitse jikin da yake akwai.

A gaban mai hepatosis mai narkewa ko cirrhosis na hanta, ɗaukar Atorvastatin sau da yawa yana buƙatar bincika haɗarin enzymes na hepatic a cikin jini, sabili da haka, a cikin rashin kiba, don magani na dogon lokaci ana bada shawara don zaɓin statin tare da ƙananan kashi na abubuwan aiki da haɗarin "sakamako masu illa", shine, Rosuvastatin.

Shafin Kwatantawa Tsarin Kwatantawa

Idan kun dogara da aikin likitanci da kuma sake dubawa game da marasa lafiya da ke daukar mutum-mutumi na wani lokaci mai tsawo, lokacin amfani da allurai masu karfi na duka halittar III da na IV, a lokuta da dama (har zuwa 3%), ana iya lura da tasirin sakamako mai wahala daga wasu bangarorin jikin mutum.

Kwatanta “sakamako masu illa” na Atorvastatin da Rosuvastatin (tebur):

Zan iya maye gurbin Atorvastatin tare da Rosuvastatin?

Idan magungunan ba su da haƙuri, wanda aka bayyana ta hanyar mummunan sakamako ga hanta, an tabbatar da shi ta hanyar lalacewar sigogi na dakin gwaje-gwaje, ya zama dole don daidaita tsarin sashi na Atorvastatin: soke ɗan lokaci, rage sashi ko zaka iya maye gurbin shi da sabon Rosuvastatin.

Ba za ku iya yin wannan da kanku ba, saboda yawanci a cikin makonni 2-4 bayan an dakatar da miyagun ƙwayoyi, matakin lipids a cikin jini ya koma darajar sa na ainihi, wanda zai iya cutar lafiyar haƙuri sosai. Sabili da haka, yanke shawara game da yiwuwar sauyawa dole ne a ɗauka tare da likita.

Mafi kyawun kwayoyi na ƙarni na 3 da na 4

A kan kasuwar magunguna, siffofin mutane na III da na IV suna wakilta duka ta hanyar magunguna na asali - Liprimar (atorvastatin) da Krestor (rosuvastatin), da wasu korafe-korafen, waɗanda ake kira. ilimin halittar jini wanda aka sanya daga abu guda mai aiki, amma a ƙarƙashin suna daban (INN):

• atorvastatin - Tulip, Atomax, Liptonorm, Torvakard, Atoris, Atorvastatin,
• rosuvastatin - Roxer, Rosucard, Mertenil, Rosulip, Lipoprime, Rosart.

Ayyukan ilimin halittar kusan daidai yake da asali, don haka mutum yana da 'yancin zaɓar irin wannan analog ɗin bisa abubuwan da aka zaɓa na mutum.

Yana da mahimmanci a fahimci cewa duk da cewa Atorvastatin da Rosuvastatin ba abu ɗaya bane, yakamata a ɗauki nauyinsu daidai: a hankali bincika lafiyar lafiyar hanta da ƙodan, a baya da kuma nan gaba, kazalika da tsayar da kulawa da tsarin kulawar da likita ya umarta, abinci da abinci aiki na jiki.

Game da statins

Ko da kuwa sunan ta (simvastatin, rosuvastatin, atorvastatin), dukkan tsoffin abubuwa suna da tsari iri daya na aiki a jikin mutum.Wadannan kwayoyi sun toshe enzyme HMG-CoA reductase, wanda yake a cikin hanta hanta kuma ya shiga cikin ƙwayar cholesterol. Haka kuma, toshe wannan enzyme ba wai kawai yana haifar da raguwar jini cholesterol ba, har ma yana rage adadin lipoproteins mai yawa da raguwa a ciki, wanda ke taka rawa ga ci gaban jijiyoyin bugun zuciya.

A lokaci guda, yawan abubuwan lipoproteins mai yawa (HDL) a cikin jini yana ƙaruwa, wanda ke cire lipids daga filayen atherosclerotic da jigilar hanta, wanda ke haifar da raguwa cikin tsananin cutar atherosclerosis da haɓakawa cikin lafiyar mai haƙuri.

Akwai manyan mutum 3 a cikin aikin ilimin zamani: rosuvastatin, atorvastatin da simvastatin.

Baya ga tasirinsa kai tsaye ga tasirin cholesterol a cikin jiki, duk jikin mutum-mutumi yana da dukiya guda daya: suna inganta yanayin bangon ciki na jijiyoyin jini, ta haka zai rage yiwuwar farawar atherosclerotic a cikin su.

Atorvastatin - wakili mai saurin rage kiba

Ana amfani da Atorvastatin da rosuvastatin don magance duk wani yanayin da ya shafi hypercholesterolemia (gado da kuma samu), da kuma don rigakafin cututtuka irin su infyoction na myocardial infarction da ischemic bugun jini. Koyaya, yawancin marasa lafiya da likitoci suna tambayar tambaya mai mahimmanci, amma wanne ya fi kyau - rosuvastatin ko atorvastatin? Don bayar da amsar daidai, ya zama dole a tattauna dukkan bambance-bambancen da ke tsakaninsu.

Tsarin sunadarai da yanayin mahadi

Abubuwan daban-daban suna da asali daban-daban - na halitta ko na roba, wanda zai iya shafar ayyukan likitancinsu da tasiri a cikin mai haƙuri. Magunguna masu gudana, kamar su simvastatin, sun bambanta da kwayar su ta roba a cikin rage aiki kuma galibi suna haifar da sakamako masu illa. Bayan haka, matakin tsarkakewa daga cikin dabbobin yana iya zama ingancin inganci.

Rosuvastatin yana cikin contraindicated a cikin marasa lafiya da aiki hanta da cutar

Obtaineda'idodi na roba (mertenyl - sunan cinikin rosuvastatin da atorvastatin) ana samun su ta hanyar haɗa abubuwa masu aiki a cikin al'adun fungal na musamman. Haka kuma, samfurin da aka samar dashi ana saninsa da babban matakin tsarkakakken yanayi, wanda yasa hakan yafi ingancin takwarorin sa na halitta.

A kowane hali ya kamata ku ɗauki gumakai don kanku, saboda girman haɗarin sakamako masu illa tare da sashi mara kyau.

Bambanci mafi mahimmanci yayin kwatanta rosuvastatin da atorvastatin shine kayan aikin kimiyyar halayyar su, watau solubility a cikin kitse da ruwa. Rosuvastatin shine mafi hydrophilic kuma yana narkewa a cikin plasma jini da kowane ruwa. Atorvastatin, akasin haka, shine mafi yawan lipophilic, i.e. yana nuna ubarin solubility a cikin mai. Bambanci a cikin waɗannan kaddarorin na haifar da bambance-bambance a sakamakon illa. Rosuvastatin yana da tasiri mafi girma akan sel hanta, da takwarorinta na lipophilic, akan tsarin kwakwalwa.

Dangane da tsari da asalin magungunan guda biyu, ba zai yiwu a gano mafi ingancin su ba. Dangane da wannan, yana da mahimmanci a kula da yadda suka bambanta da juna a cikin halayen sha da rarraba a cikin jikin mutum, da kuma tasirin tasirinsu ga cholesterol da lipoproteins na yawancin yawa.

Bambance-bambance a cikin hanyoyin sha, rarrabawa da fitarwa daga jiki

Bambance-bambance tsakanin magungunan guda biyu suna farawa ne a mataki na sha daga hanjin. Bai kamata a dauki Atorvastatin lokaci guda tare da abinci ba, tunda an rage yawan abubuwan da yake sha. Bi da bi, ana shigar da rosuvastatin a cikin kullun, ba tare da la'akari da amfani da samfurori daban-daban ba.

Bambanci tsakanin magunguna suna shafar alamu da contraindications ga rubutaccen magani.

Mafi mahimmancin batun da kwayoyi suka bambanta shine aikin haɓaka, i.e. canji a jikin mutum. Atorvastatin an canza shi zuwa nau'i mara aiki ta hanyar enzymes na musamman a cikin hanta daga dangin CYP. A wannan batun, babban canje-canje a cikin aikinsa yana da alaƙa da yanayin wannan tsarin hepatic da kuma amfani da lokaci guda na wasu kwayoyi waɗanda ke shafar shi. A wannan yanayin, babban hanyar excretion na miyagun ƙwayoyi yana da alaƙa da hutawa tare da bile. Rosuvastatin ko mertenyl, akasin haka, an keɓe shi musamman tare da feces a cikin kusan kusan canzawa.

Wadannan kwayoyi sune kyawawan zabi don kulawa na dogon lokaci na maganin hypercholesterolemia, tunda kasancewarsu cikin jini yana ba ku damar shan kwayoyi sau ɗaya kawai a rana.

Bambancin Aiki

Mafi mahimmancin batun zabar takamaiman magani shine tasirin sa, i.e. mataki na rage yawan maida hankali kan kwalakwala da rashin wadataccen lipoproteins (LDL) da kuma haɓakar babban lipoproteins da yawa (HDL).

Mertenil - wani roba magani

Lokacin da aka kwatanta rosuvastatin tare da atorvastatin a cikin gwaji na asibiti, tsohon ya fi tasiri. Mun bincika sakamakon cikin cikakkun bayanai:

• Rosuvastatin rage LDL da 10% mafi inganci fiye da takwaransa a daidai gwargwado, wanda za a iya amfani dashi a cikin lura da marasa lafiya tare da ƙayyadaddun ƙwayar cholesterol.
• Cutar cuta da mace-mace tsakanin marasa lafiyar da ke shan waɗannan magunguna suma suna da muhimmanci - kasancewar cututtukan zuciya da na jijiyoyin jiki, haka nan kuma mace-mace ta yi ƙaranci a cikin mutane da ke amfani da mertenyl.
• Abin da ya haifar da sakamako masu illa tsakanin magungunan biyu ba su bambanta ba.

Bayanan data samu sun nuna cewa rosuvastatin ta fi dacewa ta toshe HMG-CoA rage a cikin hanta, wanda hakan ke haifar da tasirin warkewa idan aka kwatanta da atorvastatin. Koyaya, farashinta zai iya taka muhimmiyar rawa wajen zaɓar takamaiman magani, wanda yakamata a la'akari da likitan halartar.

Atorvastatin da rosuvastatin sun bambanta kaɗan da juna, duk da haka, ƙarshen yana da ƙarin tasirin asibiti da bambance-bambance a cikin sakamako masu illa, wanda yakamata a yi la’akari da shi lokacin da ake rubuta magani ga wani haƙuri. Fahimtar da likitan halartar da kuma haƙuri game da bambanci tsakanin statins na iya haɓaka tasiri da amincin maganin rashin lafiyar hypocholesterolemic.