Metformin 500 MG 60 Allunan: farashi da analogues, sake dubawa

Metformin yana hana gluconeogenesis a cikin hanta, rage yawan glucose daga hanji, haɓaka amfani da keɓaɓɓen glucose, yana kuma ƙara haɓaka kyallen takarda zuwa insulin.

Ba ya cutar da ɓoyewar insulin ta hanyar ƙwayoyin beta na pancreas, baya haifar da halayen hypoglycemic. Yana rage matakin triglycerides da ƙarancin linoproteins mai yawa a cikin jini. Yanke ko rage karfin jiki.

Yana da tasirin fibrinolytic saboda hanawar ƙwaƙwalwar ƙwaƙwalwar ƙwayar plasminogen mai hanawa.

Bayan gudanar da baki, ana amfani da metformin daga ƙwayar narkewa. Bioavailability bayan ɗaukar daidaitaccen kashi shine 50-60%. Cmax a cikin jini plasma ya kai awa 2.5 bayan shigowa.

A zahiri ba a ɗaura shi da sunadaran plasma. Yana tarawa a cikin glandan ciki, tsokoki, hanta da ƙodan. Aka cire shi da kodan. T1 / 2 shine 9-12 hours.

Tare da nakasa aikin na koda, tarawa daga cikin miyagun ƙwayoyi yana yiwuwa.

Abin da Metformin yana taimakawa daga: alamomi

Nau'in ciwon sukari na 2 na manya a cikin manya (musamman a cikin marasa lafiya tare da kiba) tare da rashin tasirin maganin abinci da aikin motsa jiki, a matsayin monotherapy ko a hade tare da sauran wakilai na bakin jini ko insulin.
Nau'in nau'in ciwon sukari na 2 a cikin yara daga shekaru 10 - duka biyu a matsayin monotherapy, kuma a hade tare da insulin.

Contraindications

ketoacidosis mai ciwon sukari, precoma mai ciwon sukari, coma
lalataccen aikin na koda
cututtukan matsanancin haɗari tare da haɗarin aiki na koda
asibiti bayyanuwar bayyanar cututtuka na m da na kullum cututtuka da za su iya haifar da ci gaban da nama hypoxia (zuciya ko na numfashi kasawa, m myocardial infarction)
mummunan tiyata da rauni (lokacin da aka nuna maganin insulin)
aikin lalata hanta
na kullum barasa, guba mai guba
Yi amfani da aƙalla kwanaki 2 kafin da a cikin kwanaki biyu bayan gudanar da karatun radioisotope ko raayoyin tare da gabatarwar iodine-dauke da matsakaici matsakaici
lactic acidosis (ciki har da tarihin)
mannewa da karancin kalori (kasa da adadin kuzari 1000 / rana)
ciki
lactation
rashin hankali ga miyagun ƙwayoyi.

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin mutanen da suka haura shekaru 60 waɗanda ke yin aiki na zahiri, wanda ke da alaƙa da haɓakar haɗarin haɓakar lactic acidosis a cikinsu.

Metformin yayin Haihuwa da Shayarwa

An sanya maganin ne don amfani a lokacin daukar ciki da lokacin shayarwa .. Lokacin da ake shirin ko farawar ciki, ya kamata a dakatar da Metformin Canon kuma ya kamata ayi amfani da ilimin insulin.

Yakamata a gargadi mara lafiya game da bukatar sanar da likita idan akwai juna biyu. Ya kamata a sanya ido a uwa da yaro.

Ba'a sani ba ko ana amfani da metformin a cikin madara.

Idan ya cancanta, yi amfani da maganin yayin shayarwa, ya kamata a daina shayar da jarirai nono.

Metformin: umarnin don amfani

Ya kamata a sha allunan a baki, a hadiye su duka, ba tare da taunawa ba, a lokacin ko nan da nan bayan cin abinci, tare da ruwa mai yawa Manya Monotherapy da haɗin maganin tare da sauran wakilai na maganin ƙwayoyin cuta Wanda aka bada shawarar farawa shine 1000-1500 mg / rana.

Don rage tasirin sakamako daga ƙwayar gastrointestinal, ya kamata a raba kashi zuwa kashi 2-3. Bayan kwanaki 10-15, a cikin rashin sakamako masu illa daga ƙwayar gastrointestinal, ƙarin ci gaba a hankali a cikin kashi mai yiwuwa yana dogara da haɗuwa da glucose a cikin jini.

Doseara sauƙin amfani na iya taimaka inganta haɓakar gastrointestinal na miyagun ƙwayoyi .. Yawan kulawa yau da kullun shine 1500-2000 MG. Matsakaicin adadin yau da kullun shine 3000 MG, ya kasu kashi uku.

Lokacin da kake shirin canzawa daga ɗaukar wani wakili na hypoglycemic wakili zuwa Metformin, dole ne ka dakatar da ɗaukar wani wakili na hypoglycemic kuma fara ɗaukar Metformin Canon a cikin abubuwan da ke sama.

Hade jiki tare da insulin

Shafin farko da aka ba da shawarar maganin shine Metformin 500 MG da 850 MG - 1 kwamfutar hannu sau 2-3 a rana, Metformin 1000 MG - 1 kwamfutar hannu 1 lokaci a rana, yayin da aka zaɓi kashi na insulin dangane da haɗuwar glucose a cikin jini.

Yara sama da shekaru 10

Ana amfani da Metformin Canon a cikin maganin monotherapy kuma a hade tare da insulin.Domin shawarar farko na Metformin shine 500 MG sau ɗaya a rana tare da abinci. Bayan kwanaki 10-15, yakamata a daidaita sashi gwargwadon yawan glucose a cikin jini. Adadin kulawa shine 1000-1500 mg / rana a allurai 2-3.

Matsakaicin adadin yau da kullun shine 2000 MG a cikin kashi uku. Marasa lafiya tsofaffi Sakamakon rage yiwuwar aikin renal, ya kamata a zaɓi kashi na Metformin a ƙarƙashin kulawar yau da kullun na alamun aiki na yara (saka idanu a hankali taro na creatinine aƙalla sau 2-4 a shekara).

Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Rashin dakatar da magani ba tare da shawarar likitanka ba da shawarar.

Side effects

Daga tsarin narkewa: tashin zuciya, amai, dandano na ƙarfe a cikin bakin, rashin ci, zawo, ƙanshin ciki, ciwon ciki. Waɗannan alamun bayyanar cututtuka suna da yawa musamman a farkon magani kuma yawanci sukan tafi da kansu. Wadannan bayyanar cututtuka na iya rage sadarwar anthocides, abubuwan asali na atropine ko maganin antispasmodics.

Daga gefen metabolism: a lokuta mafi wuya - lactic acidosis (yana buƙatar dakatar da jiyya) tare da magani na dogon lokaci - hypovitaminosis B12 (malabsorption).

Daga gabobin hemopoietic: a wasu yanayi - megaloblastic anemia.

Daga tsarin endocrine: hypoglycemia.

Allergic halayen: fatar fata.

Umarni na musamman

A lokacin jiyya, wajibi ne don saka idanu kan aikin koda. Akalla sau 2 a shekara, kuma tare da bayyanar myalgia, ya kamata a ƙaddara abubuwan da ke cikin lactate na plasma.

Bugu da ƙari, sau ɗaya a kowane watanni 6 wajibi ne don sarrafa matakin ƙirar creatinine a cikin ƙwayar jini (musamman a cikin marasa lafiya na tsufa).

Bai kamata a wajabta Metformin ba idan matakin creatinine a cikin jini ya zarce 5mol / L a cikin maza kuma 110 μmol / L a cikin mata.

Wataƙila amfani da magani na Metformin a hade tare da abubuwan da aka samo na sulfonylurea. A wannan yanayin, musamman saka idanu na matakan glucose na jini ya zama dole.

Awanni 48 kafin da kuma cikin awanni 48 bayan aikin rediyo (urography, iv angiography), ya kamata ka daina shan Metformin.

Idan mai haƙuri ya kamu da cututtukan bronchopulmonary ko cuta mai cuta ta gabobin ƙwayar cuta, ya kamata a sanar da likitan da ke halartar nan da nan.

Yayin aikin jiyya, ya kamata ku guji shan barasa da kwayoyi waɗanda ke ɗauke da ethanol. .

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Yin amfani da miyagun ƙwayoyi a cikin monotherapy ba ya shafar ikon fitar da motoci da aiki tare da kayan aikin injiniya.

Lokacin da aka haɗu da Metformin tare da sauran wakilai na hypoglycemic (abubuwan da keɓaɓɓe na sulfonylurea, insulin), yanayin hypoglycemic na iya haɓakawa wanda ikon iya tuki motocin da shiga cikin wasu ayyukan haɗari masu haɗari waɗanda ke buƙatar ƙara kulawa da saurin psychomotor mai rauni.

Yarda da wasu kwayoyi

Haɗaɗɗan Contraindicated haɗuwa Nazarin ilmin rediyo ta amfani da magungunan paineine mai dauke da iodine na iya haifar da haɓakar lactic acidosis a cikin marasa lafiya tare da ciwon sukari na mellitus a kan asalin lalacewar aikin koda.

Ya kamata a dakatar da amfani da metformin awanni 48 kafin kuma ba a sake sabunta shi ba kafin awanni 48 bayan gwajin X-ray ta amfani da magunguna na radiopaque.

Haɗakarwa da aka ba da shawarar Tare da amfani da metformin na lokaci guda tare da barasa da ethanol-kwayoyi, a lokacin shan giya mai ƙarfi, lokacin azumi ko bin abinci mai kalori, kazalika da gazawar hanta, haɗarin lactic acidosis yana ƙaruwa.

Haɗuwa da ke buƙatar kulawa ta musamman Tare da yin amfani da metformin lokaci guda tare da danazol, tasirin haɓakawa na iya haɓaka. Idan jiyya tare da danazol ya zama dole kuma bayan dakatar dashi, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar tattarawar glucose na jini.

Chlorpromazine a cikin allurai masu yawa (100 mg / day) yana rage sakin insulin kuma yana kara yawan glucose a cikin jini. Tare da yin amfani da lokaci ɗaya tare da maganin tari da kuma bayan dakatar da gudanarwar su, ana buƙatar daidaita sashi na metformin a ƙarƙashin kula da maida hankali na glucose jini.

Glucocorticosteroids (GCS) tare da parenteral da Topical amfani rage haƙuri glucose da kuma ƙara taro na glucose a cikin jini, a wasu yanayi haifar ketosis. Idan kuna buƙatar amfani da wannan haɗin kuma bayan dakatar da gudanarwar corticosteroids, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar maida hankali na glucose jini.

Tare da yin amfani da "madauki" diuretics da metformin, akwai haɗarin lactic acidosis saboda bayyanar yiwuwar lalacewa ta aiki na aiki. Allurar beta2-adrenergic agonists yana rage tasirin hypoglycemic na metformin saboda haɓakar masu karɓar beta2-adrenergic.

A wannan yanayin, yakamata a kula da yawan glucose a cikin jini kuma idan ya cancanta, yakamata ayi amfani da insulin .. Masu hana angiotensin canza enzyme da sauran magungunan antihypertensive zasu iya rage yawan glucose a cikin jini. Idan ya cancanta, ya kamata a daidaita sashi na metformin Tare da yin amfani da metformin lokaci guda tare da abubuwan da ake amfani da su na sulfonylurea, insulin, acarbose da salicylates, haɓaka tasirin hypoglycemic mai yiwuwa ne.

Nifedipine yana haɓaka ɗaukar ciki da Cmax na metformin, wanda dole ne a la'akari lokacin amfani dashi lokaci guda.

"Dipback" diuretics da magungunan anti-inflammatory anti-inflammatory (NSAIDs) suna kara hadarin raguwar aikin kodan. A wannan yanayin, dole ne a kula yayin amfani da metformin.

Yawan damuwa

Bayyanar cututtuka: tare da yin amfani da metformin a kashi na 85 g, ba a lura da cutar hypoglycemia ba, duk da haka, an lura da ci gaban lactic acidosis.

Alamomin farko na lactic acidosis sune tashin zuciya, amai, gudawa, zazzabi a jiki, raunin ciki, zafin makogwaro, a nan gaba ana iya samun yawan numfashi, farin ciki, rashin nutsuwa da kuma ci gaba.

Jiyya: Idan akwai alamun lactic acidosis, magani tare da miyagun ƙwayoyi ya kamata a dakatar da shi nan da nan, ya kamata a kwantar da mai haƙuri cikin gaggawa kuma, tunda ya ƙaddara maida hankali kan lactate, ya kamata a fayyace cutar. Mafi girman gwargwado don cire lactate da metformin daga jiki shine hemodialysis. Hakanan ana gudanar da aikin tiyata.

Analogs da farashin

Daga cikin analogues na kasashen waje da na Rasha, ana bambanta Metformin:

Metformin Richter. Mai gabatarwa: Gideon Richter (Hungary). Farashin a cikin kantin magani ya kasance daga 180 rubles.
Glucophage mai tsawo. Mai gabatarwa: Merck Sante (Norway). Farashin a cikin kantin magunguna daga 285 rubles. Gliformin. Mai kera: Akrikhin (Russia). Farashin a cikin kantin magani ya kasance daga 186 rubles.

Siofor 1000. Mai gabatarwa: Berlin-Chemie / Menarini (Jamus). Farashin a cikin kantin magani ya kasance daga 436 rubles.

Metfogamma 850. Mai masana'anta: Werwag Pharma (Jamus). Farashin a cikin kantin magunguna daga 346 rubles.

Mun sami waɗannan ra'ayoyin ta atomatik game da Metformin akan Intanet:

Babu 500 MG, Na sayi 1000. Halin da ke kan kwamfutar hannu yana da dacewa sosai, ana iya rarrabashi cikin sau biyu, musamman tunda kwamfutar hannu tana da tsari sosai.

A ƙasa zaku iya barin bita! Shin Metformin yana Taimaka Wajan Cire Cutar?

Metformin 500 MG 60 Allunan: farashi da analogues, sake dubawa

Lokacin amfani da maganin Metformin 500, ya kamata a tuna cewa yana iya tayar da sakamako masu yawa a cikin jiki. Ana yin Metformin ta masana'antar magunguna a cikin nau'ikan allunan da aka saka tare da zane na musamman na fim.

Tabletaya daga cikin kwamfutar hannu Metformin ya ƙunshi 500 MG na aiki Metformin mai aiki a cikin tsarin sinadaran. Kwayar aiki mai aiki a cikin abubuwan da ke cikin magani yana cikin nau'i na hydrochloride.

Bayan babban fili mai aiki, abun da ke ciki na allunan ya hada da ƙarin mahadi wadanda ke yin aikin taimako.

Karin abubuwanda suka hada allunan Metformin sune:

microcrystalline cellulose,
abdallashanka,
tsarkakakken ruwa
polyvinylpyrrolidone,
magnesium stearate.

Kwayar aiki mai aiki, metformin hydrochloride, biguanide ne. Ayyukan wannan fili ya dogara da ikon hana ayyukan gluconeogenesis da ake gudanarwa a cikin hanta hanta.

Kayan yana taimakawa rage girman yadda ake daukar glucose daga kashin gastrointestinal fili da kuma haɓaka ɗaukar glucose daga ƙwayar jini ta sel waɗanda keɓaɓɓun kasusuwa na jiki.

Aikin miyagun ƙwayoyi an yi niyya ne don haɓaka ji na jijiyoyin jiki waɗanda keɓaɓɓen ƙwayoyin sel zuwa insulin na hormone. Magungunan ba shi da ikon yin tasiri kan ayyukan da ke tabbatar da ƙirar insulin a cikin ƙwayoyin ƙwayar tsoka kuma baya tsokani bayyanar alamun hypoglycemia a cikin jiki.

Magungunan yana taimakawa dakatar da alamun hyperinsulinemia. Latterarshe shine mafi mahimmancin mahimmanci wanda ke ba da gudummawa ga karuwar nauyin jiki da ci gaban rikice-rikice masu alaƙa da aikin tsarin jijiyoyin jini a cikin ciwon sukari. Shan magani yana haifar da daidaiton yanayin jikin mutum da rage karfin jikin mutum.

Yin amfani da magani yana rage yawan ƙwayar plasma na triglycerides da ƙarancin linoproteins mai yawa.

Shan miyagun ƙwayoyi yana haifar da raguwa a cikin yawan ayyukan ƙurawar iskar shaka da kuma hana aiwatar da samar da kitse mai mai. Bugu da ƙari, an bayyana tasirin fibrinolytic na abu mai aiki a jiki, PAI-1 da t-PA an hana su.

Allunan suna ba da gudummawa ga dakatarwar ci gaban haɓaka abubuwa na tsokoki na ganuwar jijiyoyin jiki.

An bayyana tasirin sakamako na magani akan yanayin gaba ɗaya na tsarin zuciya da jijiyoyin bugun jini, wanda ke hana ci gaba da cutar ciwon sukari.

Amfani da magani

Ana ɗaukar allunan Metformin a baki.

Lokacin shan magungunan, ana bada shawara cewa za'a ƙone allunan gaba ɗaya ba tare da an cuce su ba.

Ya kamata a yi amfani da miyagun ƙwayoyi a lokacin abinci ko kuma nan da nan bayan shi. Auki kwaya tare da isasshen ƙarfin ruwa.

Babban mahimmancin amfani da magani shine kasancewar nau'in ciwon sukari na 2 a cikin haƙuri.

Umarnin don yin amfani da shi yana nuna cewa za'a iya amfani da maganin a cikin tsarin monotherapy ko kuma azaman ɓangaren hadadden farke tare da wasu jami'ai tare da kaddarorin hypoglycemic ko a hade tare da inulin.

Umarnin don amfani yana ba da damar yin amfani da miyagun ƙwayoyi a cikin yara, farawa daga shekaru 10. An yarda da yin amfani da miyagun ƙwayoyi don yara duka biyu a matsayin maganin monotherapy, kuma a hade tare da injections insulin.

Sigar farko lokacin shan magani shine 500 MG. Ana ba da shawarar maganin don shan sau 2-3 a rana. Idan ya cancanta, tare da ƙarin shiga, ana iya ƙara adadin ƙwayar.Increasearin yawan sigogin da aka dauka ya dogara da matakin ƙwayar glucose a cikin jiki.

Lokacin amfani da Metformin a cikin aikin maganin kulawa, ƙimar da aka ɗauka ya bambanta daga 1,500 zuwa MG 2,000 a rana.

Ya kamata a raba magungunan yau da kullun zuwa sau 2-3, wannan amfani da miyagun ƙwayoyi yana nisantar bayyanar da mummunan sakamako masu illa daga ƙwayar gastrointestinal.

Matsakaicin izini na gwargwado daidai da umarnin don amfani shine 3000 MG kowace rana.

Lokacin shan miyagun ƙwayoyi, ya kamata a ƙara yawan ƙwayar a hankali har sai an sami ƙimar mafi kyau, wannan dabarar zata inganta haƙurin maganin zuwa ƙwayar gastrointestinal.

Idan mai haƙuri ya fara shan Metformin bayan wani magani na hypoglycemic, to, kafin ɗaukar Metformin wani magani ya kamata a dakatar dashi gaba daya.

Lokacin amfani da miyagun ƙwayoyi a lokacin ƙuruciya, yakamata a fara magani tare da sashi na 500 MG sau ɗaya a rana.

Bayan kwanaki 10-15, ana aiwatar da gwajin jini don glucose kuma, idan ya cancanta, ana daidaita yawan maganin da aka sha.

Matsakaicin adadin maganin yau da kullun ga marasa lafiya a yara shine 2000 MG. Wannan kashi ya kamata ya kasu kashi biyu-biyu a kowace rana.

Idan tsofaffi ke amfani da maganin, tsofaffin hanyoyin ya kamata a aiwatar da su a ƙarƙashin tsananin kulawa daga likitocin da ke halartar. Wannan buƙatun yana kasancewa saboda gaskiyar cewa a cikin tsofaffi, haɓaka digiri daban-daban na rashin nasara na yara a cikin jiki yana yiwuwa.

Tsawon likitan da likitan halartar ya tabbatar da tsawon lokacin amfani da miyagun ƙwayoyi.

A lokacin warkarwa, magani bai kamata a katse ba tare da umarnin likitan halartar ba.

Abubuwan da suka faru da mummunan sakamako tare da maganin Metformin

Umarnin don amfani da Metformin ya bayyana dalla-dalla game da duk tasirin sakamako na amfani da magani.

Dukkanin sakamako masu illa waɗanda suka faru lokacin amfani da miyagun ƙwayoyi za'a iya rarraba su zuwa manyan manyan rukuni.

Abubuwan da ke haifar da sakamako sun kasu kashi biyu, ba a sani ba, ba kasada ba, ba kasafai ba ne kuma ba a san su ba.

Ba wuya, sakamako masu illa kamar lactic acidosis a cikin nau'in ciwon sukari na 2 ya faru.

Tare da tsawaita amfani da miyagun ƙwayoyi, akwai raguwa a cikin shan ƙwayar bitamin B12. Idan mai haƙuri yana da cutar tasirin megaloblastic, ya zama dole yin la'akari da yiwuwar haɓaka irin wannan yanayin.

Babban sakamako masu illa sune kamar haka:

take hakkin dandano,
rushewa daga cikin narkewa,
jin tashin zuciya
Bayyanar vomiting
aukuwa na jin zafi a ciki,
rage cin abinci.

Wadannan sakamako masu illa suna haifar da mafi yawan lokuta a farkon lokacin shan maganin kuma mafi yawan lokuta a hankali suna ɓacewa.

Bugu da ƙari, waɗannan sakamako masu illa na iya faruwa:

Abubuwan da suka shafi fata a cikin yanayin itching da fatar jiki.
Paarancin aiki na hanta da ƙwayar ƙwayar cuta ta biliary.

A cikin lokuta masu wuya, hepatitis na iya haɓaka a cikin jiki.

Sakamakon sakamako wanda ke faruwa lokacin amfani da miyagun ƙwayoyi a cikin marasa lafiyar yara suna kama da sakamako masu illa waɗanda ke fitowa a cikin marasa lafiyar manya.

Analogues na miyagun ƙwayoyi da farashin sa da sakin sa

Ana samun magungunan a cikin nau'ikan allunan. Allunan ana kunshe-kunshe a fakiti mai bakin ciki wanda aka yi da polyvinyl chloride da kuma tsare aluminium. Kowane fakitin ya ƙunshi Allunan 10.

Ana sanya fakitoci shida cikin kwali na kwali, wanda ya ƙunshi umarnin don amfani. Akwatin kwali na miyagun ƙwayoyi ya ƙunshi allunan 60.

Adana kwayoyi a wurin da aka kiyaye shi daga hasken rana kai tsaye a zazzabi da bai wuce digiri 25 Celsius ba. Dole ne a adana magungunan ba tare da isa ga yara ba.

Rayuwar rayuwar shiryayye na samfurin likita shine shekaru uku. Ana sayar da maganin a cikin kantin magunguna ta hanyar sayan magani.

Yawancin bita-bita da marasa lafiya ke amfani da wannan magani suna da inganci.

Bayyanuwa na sake dubawa mara kyau shine yawancin lokuta ana danganta su da keta umarnin umarnin amfani da miyagun ƙwayoyi ko kuma idan ya keta shawarar da aka karɓa daga likitan halartar.

Sau da yawa akwai sake dubawa na marasa lafiya, wanda ke nuna cewa yawan amfani da magunguna yana rage nauyin jiki.

Babban kamfanin samar da magunguna a cikin Tarayyar Rasha shine Ozone LLC.

Farashin magani a kan ƙasa na Tarayyar Rasha ya dogara da cibiyar sadarwa na kantin magani da yankin da ke sayar da magani. Matsakaicin farashin magani a cikin Tarayyar Rasha ya tashi daga 105 zuwa 125 rubles a kowane fakiti.

Hanyoyin da aka fi sani dasu na Metformin 500 a cikin Federationungiyar Rasha sune waɗannan:

Bagomet,
Glycon
Glyminfor,
Glyformin
Glucophage,
Glucophage Tsawon,
Methadiene
Metospanin
Metfogamma 500,
Metformin
Karin Richter,
Metformin Teva,
Metformin hydrochloride,
Nova Sanda
Lankaranna,
Siofor 500,
Sofamet
A tsari,
Kayan tsari.

Tsarin da aka ambata ana amfani da Metformin iri daya ne a tsarin tsari da kuma bangaren aiki.

Yawancin analogues na ƙwayoyin cuta na Metformin suna ba da damar, idan ya cancanta, likitan halartar don sauƙaƙe zaɓin maganin da ake buƙata kuma maye gurbin Metformin tare da wani na'urar likita. Game da yadda Metformin ke aiki a cikin ciwon sukari, ƙwararren masani zai faɗi a cikin bidiyo a wannan labarin.

Nuna sukari ko zaɓi jinsi don shawarwari.Bayan bincike ba a samu ba Show ShowNa bincike ba a samu ba.

Oral hypoglycemic magani

Tsarin saki, abun da aka shirya da marufi

Allunan Mai Sanda Komai fari, zagaye, biconvex.

Shafin 1metformin hydrochloride 500 MG

Mahalarta: povidone K90, sitaci masara, crospovidone, magnesium stearate, talc.

Harshen Shell: methaclates acid da methyl methacrylate copolymer (Eudragit L 100-55), macrogol 6000, titanium dioxide, talc.

10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.

Pharmacokinetics

Bayan gudanar da baki, ana amfani da metformin daga ƙwayar narkewa. Bioavailability bayan ɗaukar daidaitaccen kashi shine 50-60%. Cmax a cikin jini plasma ya kai awa 2.5 bayan shigowa.

A zahiri ba a ɗaura shi da sunadaran plasma. Yana tarawa a cikin glandan ciki, tsokoki, hanta da ƙodan. Aka cire shi da kodan. T1 / 2 shine 9-12 hours.

Tare da nakasa aikin na koda, tarawa daga cikin miyagun ƙwayoyi yana yiwuwa.

- kamuwa da cutar sankarar mellitus 2 ba tare da nuna sha'awar ketoacidosis (musamman ma a cikin marasa lafiya da kiba) tare da rashin tasirin maganin abinci,

- a hade tare da insulin - don nau'in ciwon sukari na 2 na sukari, musamman tare da digiri mai yawa na kiba, tare da juriya na insulin na sakandare.

Ana saita yawan maganin a likitoci daban-daban, gwargwadon matakin glucose a cikin jini.

Maganin farko shine 500-1000 mg / rana (Allunan 1-2). Bayan kwanaki 10-15, karin ci gaba a hankali yana kan yawan matakan glucose na jini.

Adadin kulawa da miyagun ƙwayoyi yawanci 1500-2000 mg / rana. (3 shafin.) Matsakaicin adadin shine 3000 mg / rana (Allunan Allunan) 6.

A tsofaffi marasa lafiya da shawarar yau da kullun kada ta wuce 1 g (2 Allunan).

Ya kamata a ɗaukar allunan Metformin duka lokacin ko kuma kai tsaye bayan abinci tare da karamin adadin ruwa (gilashin ruwa). Don rage tasirin sakamako daga cututtukan gastrointestinal, ya kamata a raba kashi na yau da kullum zuwa kashi 2-3.

Saboda haɓakar haɗarin lactic acidosis, yakamata a rage kashi idan akwai mummunan rikice-rikice na rayuwa.

Daga gefen metabolism: a lokuta mafi wuya - lactic acidosis (yana buƙatar dakatar da magani), tare da magani na dogon lokaci - hypovitaminosis B12 (malabsorption).

Daga gabobin hemopoietic: a wasu yanayi - megaloblastic anemia.

Daga tsarin endocrine: hypoglycemia.

Allergic halayen: fatar fata.

Hulɗa da ƙwayoyi

Kada a bada shawarar yin amfani da gudaz din danazol a lokaci guda don guje wa tasirin karshen rayuwar. Idan magani tare da danazol ya zama dole kuma bayan dakatar da ƙarshen, ana buƙatar daidaita sashi na metformin da iodine don sarrafa matakin glycemia.

Haɗuwa da ke buƙatar kulawa ta musamman: chlorpromazine - lokacin da aka ɗauka cikin manyan allurai (100 MG / rana) yana ƙaruwa glycemia, yana rage ƙaddamar da insulin.

A cikin maganin rigakafin ƙwayar cuta da kuma bayan dakatar da ɗayan na ƙarshe, ana buƙatar daidaita sashi na metformin a ƙarƙashin kula da matakin glycemia.

Tare da yin amfani da lokaci guda tare da abubuwan da suka samo asali na sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, Clofibrate Kalam, cyclophosphamide, β-blockers, yana yiwuwa a ƙara tasirin hypoglycemic sakamako na metformin.

Tare da yin amfani da lokaci guda tare da GCS, hana hana haihuwa, epinephrine, sympathomimetics, glucagon, hormones thyroid, thiazide da loop diuretics, abubuwan da aka samo na phenothiazine, abubuwan nicotinic acid, raguwar sakamako na hypoglycemic na metformin mai yiwuwa ne.

Cimetidine yana rage jinkirin kawar da metformin, wanda ke kara haɗarin lactic acidosis.

Metformin na iya raunana tasirin magungunan anticoagulants (abubuwan da aka samo coumarin).

Shan barasa yana haifar da haɗarin haɓakar lactic acidosis a lokacin shan giya mai ƙarfi, musamman a cikin lokuta na azumi ko bin abinci mai kalori, kazalika da gazawar hanta.

Haihuwa da lactation

Lokacin da ake shirin yin ciki, da kuma lokacin da ake yin ciki yayin daukar Metformin, ya kamata a soke shi kuma ya kamata a tsara maganin insulin. Tunda babu bayanai game da shigar azzakari cikin nono, wannan maganin yana cikin kansar shayarwa. Idan kuna buƙatar amfani da Metformin yayin shayarwa, ya kamata a daina shayar da jarirai.

Sharuɗɗan da yanayin ajiya

Adana a cikin bushe, wuri mai duhu a zazzabi na 15 zuwa 25 ° C. Ayi nesa da isar yara. Lokacin jiran shine shekaru 3.

Bayanin METFORMIN na miyagun ƙwayoyi ya dogara da umarnin hukuma da aka amince da shi don amfani da shi kuma masana'antar sun yarda da shi.

An sami kuskure? Zaɓi shi kuma latsa Ctrl + Shigar.

Gefen sakamako Metformin

Daga tsarin juyayi na tsakiya:

take hakki da dandano (“karafa” dandano a bakin).

Daga cikin jijiyoyin mahaifa:

tashin zuciya
amai
diar
ciwon ciki da rashin ci.

Abunda ya faru wadannan cututtukan suna iya yiwuwa a lokacin farko na magani kuma a mafi yawan lokuta suna wucewa ne lokaci-lokaci.

Don hana bayyanar cututtuka, ana ba da shawarar ku ɗauki metformin yayin ko bayan abinci.

Dosearanci a hankali na iya inganta haɓakar gastrointestinal.

Daga tsarin hepatobiliary:

take hakkin alamomin aikin hanta,
hepatitis.

Bayan shafe metformin, abubuwan da suka faru na wulakantawa, a matsayin mai mulkin, gaba daya sun shuɗe.

Allergic halayen:

da wuya - erythema,
fata
kurji
cututtukan mahaifa.

Daga gefen metabolism:

da wuya sosai - lactic acidosis (yana buƙatar dakatar da miyagun ƙwayoyi).

Sauran:

da wuya - tare da tsawaita amfani, hypovitaminosis B12 yana haɓaka (ciki har da megaloblastic anemia) da folic acid (malabsorption).

Bayanai da aka buga sun nuna cewa a iyakantaccen yawan yara masu shekaru 10 zuwa 16, tasirin sakamako iri ɗaya ne cikin yanayi da kuma tsananin girman waɗanda ke cikin majinyata na manya.

Alamu don amfani

Nau'in nau'in ciwon sukari na 2 a cikin yara daga shekaru 10 - duka biyu a matsayin monotherapy, kuma a hade tare da insulin.

Sashi da gudanarwa

Allunan ya kamata a ɗauka a baki, suna haɗiye duka, ba tare da taunawa ba, a lokacin ko kai tsaye bayan cin abinci, shan ruwa mai yawa.

Monotherapy da maganin haɗin gwiwa tare da wasu wakilai na maganin ƙwaƙwalwar ƙwayar cuta Na bada shawarar farko shine 1000-1500 mg / rana.

Don rage tasirin sakamako daga ƙwayar gastrointestinal, ya kamata a raba kashi zuwa kashi 2-3.

Bayan kwanaki 10-15, a cikin rashin sakamako masu illa daga ƙwayar gastrointestinal, ƙarin ci gaba a hankali a cikin kashi mai yiwuwa yana dogara da haɗuwa da glucose a cikin jini.

Dosearfafawa mai saurin motsa jiki na iya taimakawa inganta haƙuri haƙuri.

Adadin yau da kullun shine 1500-2000 mg.

Matsakaicin adadin yau da kullun shine 3000 MG, ya kasu kashi uku.

Lokacin da kake shirin sauyawa daga ɗaukar wani wakili na hypoglycemic wakili zuwa Metformin Canon, dole ne ka dakatar da ɗaukar wani wakili na hypoglycemic kuma fara ɗaukar Metformin Canon a cikin abubuwan da ke sama.

Hade jiki tare da insulin.

A shawarar farko na miyagun ƙwayoyi shine 500 MG da 850 MG - 1 kwamfutar hannu sau 2-3 a rana, miyagun ƙwayoyi 1000 MG - 1 kwamfutar hannu 1 lokaci 1 kowace rana, an zaɓi kashi na insulin a kan tushen taro glucose jini.

Yara sama da shekaru 10.

Ana amfani da Metformin Canon a cikin monotherapy kuma a hade far tare da insulin.

Shawarar farko na maganin shine 500 MG 1 lokaci ɗaya a maraice tare da abinci.

Bayan kwanaki 10-15, yakamata a daidaita sashi gwargwadon yawan glucose a cikin jini.

Adadin kulawa shine 1000-1500 mg / rana a allurai 2-3.

Matsakaicin adadin yau da kullun shine 2000 MG a cikin allurai uku.

Tsofaffi marasa lafiya.

Saboda yiwuwar raguwa a aikin na koda, ya kamata a zaɓi kashi na maganin a ƙarƙashin saka idanu na yau da kullun akan alamun alamun aikin koda (sa ido kan haɗarin creatinine a cikin ƙwayar jini a kalla sau 2-4 a shekara).

Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Rashin dakatar da magani ba tare da shawarar likitanka ba da shawarar.

Haɗa kai

Nazarin aikin rediyo ta amfani da magungunan iodine mai dauke da maganin radiopaque na iya haifar da haɓakar lactic acidosis a cikin marasa lafiya da masu ciwon sukari na mellitus a kan asalin lalacewar aikin koda.

Ya kamata a dakatar da amfani da metformin awanni 48 kafin kuma ba a sake sabunta shi ba kafin awanni 48 bayan gwajin X-ray ta amfani da magunguna na radiopaque.

Tare da yin amfani da metformin lokaci guda tare da barasa da ethanol-da kwayoyi, a lokacin shan barasa mai sa maye, tare da matsananciyar abinci ko ƙarancin kalori, kazalika da gazawar hanta, haɗarin lactic acidosis yana ƙaruwa.

Haɗuwa yana buƙatar matuƙar taka tsantsan.

Tare da yin amfani da metformin lokaci guda tare da danazole, haɓaka tasirin hyperglycemic mai yiwuwa ne.

Idan jiyya tare da danazol ya zama dole kuma bayan dakatar dashi, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar tattarawar glucose na jini.

Chlorpromazine a cikin allurai masu yawa (100 mg / day) yana rage sakin insulin kuma yana kara yawan glucose a cikin jini.

Tare da yin amfani da lokaci ɗaya tare da maganin tari da kuma bayan dakatar da gudanarwar su, ana buƙatar daidaita sashi na metformin a ƙarƙashin kula da maida hankali na glucose jini.

Glucocorticosteroids (GCS) tare da parenteral da Topical amfani rage haƙuri glucose da kuma ƙara taro na glucose a cikin jini, a wasu yanayi haifar ketosis.

Idan kuna buƙatar amfani da wannan haɗin kuma bayan dakatar da gudanarwar corticosteroids, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar maida hankali na glucose jini.

Tare da amfani da "madauki" diuretics da metformin, lokaci ɗaya akwai haɗarin lactic acidosis saboda bayyanar yiwuwar lalacewa ta aiki.

Yin amfani da agonists na beta2-adrenergic a cikin hanyar injections yana rage tasirin hypoglycemic na metformin saboda haɓakar masu karɓar beta2-adrenergic.

A wannan yanayin, yakamata a kula da yawan glucose a cikin jini kuma idan ya cancanta, yakamata ayi amfani da insulin.

Angiotensin-mai canza tsofaffin masu hana enzyme da sauran magungunan rigakafin jini na iya rage glucose jini.

Idan ya cancanta, ya kamata a daidaita sashi na metformin.

Ta yin amfani da metformin na lokaci guda tare da abubuwan da suka samo asali na sulfonylurea, insulin, acarbose da salicylates, haɓaka tasirin hypoglycemic mai yiwuwa ne.

Nifedipine yana haɓaka ɗaukar ciki da Cmax na metformin, wanda dole ne a la'akari lokacin amfani dashi lokaci guda. "Dipback" diuretics da magungunan anti-inflammatory anti-inflammatory (NSAIDs) suna kara hadarin raguwar aikin kodan.

A wannan yanayin, dole ne a kula yayin amfani da metformin.