Metformin Canon: umarni don amfani da dalilin da yasa ake buƙata

Metformin Canon: umarnin don amfani da sake dubawa

Sunan Latin: Metformin-Canon

Lambar ATX: A10BA02

Ingantaccen kayan aiki: Metformin (Metformin)

Mai samarwa: KANONFARMA Production, CJSC (Russia), NPO FarmVILAR, OOO (Russia)

Ofaukaka bayanin da hoto: 10.24.2018

Farashin kuɗi a cikin kantin magani: daga 85 rubles.

Metformin Canon magani ne na hypoglycemic.

Formaddamar da tsari da abun da ke ciki

Sashi nau'in sakin Metformin Canon - allunan da aka sanya fim:

  • Metformin Canon 500 MG: biconvex, zagaye, kusan fari ko fari (a cikin ɗayan ajiyar bakin ciki 10 ko 15., A cikin kwali na 3, 5, 6, 10 ko 12 fakitoci 10 inji mai kwakwalwa., 2, 4 ko 8 fakitoci na 15 inji mai kwakwalwa.)
  • Metformin Canon 850 MG da 1000 MG: biconvex, m, kusan fararen fata ne ko fararen fata (a cikin fakitin bokaye guda 10., A cikin kwali na kwali na 3, 5, 6, 10 ko 12 fakitoci).

Abinda ke ciki 1 kwamfutar hannu Metformin Canon 500 MG, 850 MG da 1000 MG, bi da bi:

  • abu mai aiki: metformin hydrochloride - 0.5, 0.85 ko 1 g,
  • kayan taimako: macrogol (polyethylene glycol 6000) - 0.012, 0.020 4 ko 0.024 g, talc - 0.003, 0.005 1 ko 0,006 g, povidone - 0.047, 0.079 9 ko 0.094 g, sodium stearyl fumarate - 0.003, 0.005 1 ko sms6 - 0.008, 0.013 6 ko 0.016 g, sitaci pregelatinized - 0.027, 0.045 9 ko 0.054 g,
  • shafi fim: Opadry II fari - 0.018, 0.03 ko 0.036 g, gami da talc - 0.003 132, 0.005 22 ko 0.006 264 g, titanium dioxide - 0.002 178, 0.003 63 ko 0.004 356 g, macrogol (polyethylene glycol) - 0.004 248, 0.007 08 ko 0.008 496 g, polyvinyl barasa 0.008 442, 0.014 07 ko 0.016 884 g.

Pharmacodynamics

Abubuwan da ke aiki na miyagun ƙwayoyi, metformin, wakili ne na bakin jini wanda ke cikin rukunin biguanide.

Ayyukan Metformin Canon, saboda abu mai aiki da aka haɗa a cikin abun da ke ciki:

  • raguwa a cikin taro na glucose na jini ta hanyar ƙara yawan amfani da shi a cikin kyallen takarda ta hanyar kara yawan hankalinsu ga insulin (galibi mai ɗaukar ƙwayar tsoka, zuwa ƙarancin ƙara ƙarfin nama), rage ƙoshinsa daga ƙwayar gastrointestinal da kuma hana hanta gluconeogenesis a cikin marasa lafiya da ciwon sukari mellitus ,
  • tashin hankali na ƙwayar kwalliya ta hanyar kunna tasirin glycogen,
  • Rashin motsawar insulin insulin da kuma aiki da jini a cikin mutane masu lafiya (sabanin abubuwan da aka samo na sulfonylurea),
  • raguwa a cikin taro a cikin jini mai yawa na lipoproteins mai yawa, cholesterol da triglycerides,
  • karfafawa ko asarar nauyi,
  • tasirin zazzageolytic ta hanyar hana nau'in plasminogen mai kunna nama kunna nama.

Pharmacokinetics

  • sha daga ciki yayin da aka sha shi da bakin mutum shine 48-52%, jinkirta lokaci daya yana rage shakar shaye, cikakke na bioavailability ya bambanta daga 50 zuwa 60%, Cmax (mafi girman hankali a cikin jini) shine 2 mcg a 1 ml, TSmax (lokaci don isa a maida hankali) - 1.81-2.69 a,
  • rarrabuwa: da sauri aka rarraba a cikin nama, ya shiga cikin sel jini, yana tattarawa a cikin kodan, hanta da glandon salivary, ƙarar rarraba (don kashi 0.85 g) shine 296-1012 l, yana da ƙananan haɗin gwiwa tare da furotin plasma,
  • metabolism: yana fama da talauci sosai,
  • excretion: an kebe shi musamman ta hanyar da ba a canza shi ba ta hanyar kodan, sharewar shi cikin mutane masu lafiya shine 0.4 l cikin 1 min, T1/2 (rabin-rayuwa) shine 6.2 hours (farko ya bambanta tsakanin 1.7-3 hours, m - 9-17 hours), a lokuta na renal gazawar T1/2 yana ƙaruwa kuma akwai haɗarin tarin ƙwayoyi.

Alamu don amfani

  • manya (musamman masu kiba): monotherapy ko magani hade da insulin ko wasu maganganu na bakin jini na nau'in ciwon sukari na 2 a yanayinda aikin motsa jiki da ilimin abinci basa tasiri,
  • Yara sama da shekaru 10: maganin monotherapy ko magani hade tare da insulin type 2 diabetes mellitus.

Wanene aka wajabta maganin

Ya zuwa yanzu, jerin abubuwan da ke nuna shan shan Metformin Canon yana iyakance ga nau'in ciwon sukari guda 2 kawai da kuma yanayin da ya gabata. Kwanan nan, iyakokin magunguna suna faɗaɗa. Yiwuwar amfani dashi a cikin mutane masu kiba, cututtukan jijiyoyin jiki, dyslipidemia ana yin la'akari.

Alamu don alƙawari daga umarnin:

  • Sakamakon ciwon sukari a cikin manya da yara daga shekaru 10. Dole ne a haɗu da miyagun ƙwayoyi tare da tsarin abinci da ilimin jiki. Yi amfani da wasu allunan hypoglycemic da insulin an yarda. Ana lura da kyakkyawan sakamako na magani a cikin masu ciwon sukari.
  • Don hana haɓakar ciwon sukari a cikin mutane tare da hali don hana haɓakar metabolism. An tsara miyagun ƙwayoyi idan mai haƙuri ba zai iya samun daidaituwa na glycemia tare da abinci da wasanni ba, kuma an ƙayyade haɗarin ciwon sukari a matsayin mai girma. Musamman Metformin an ba da shawarar musamman ga mutanen da suka wuce 60 tare da mummunan kiba, ƙarancin gado (ciwon sukari a cikin ɗayan iyayen), raunin ƙwayar cuta ta hanta, hauhawar jini, da tarihin ciwon sukari na gestational.

Ba kamar Metformin ba

Don nuna wurin da miyagun ƙwayoyi na Metformin Canon a tsakanin sauran allunan da ake kira Metformin, za mu juya zuwa tarihin. Anyi amfani da Biguanides a cikin magani na ƙarni da yawa. Koda a lokacin Tsararru na Tsakiya, an kula da maganin urination tare da infusions daga tsire-tsire na Galega officinalis. A cikin Turai, sananne ne a ƙarƙashin sunaye daban-daban - Lilac na Faransa, ciyawar farfesa, akuya (karanta game da akuya na magani), a cikin Rasha suna yawan kiran shi da Lily na Faransa.

Asirin wannan tsiron ya fito daga farkon karni na 20. Abun, wanda ya ba da tasirin rage sukari, an sanya shi da sunan guanidine. An ware daga tsire, guanidine a cikin ciwon sukari ya nuna sakamako mai rauni, amma yawan guba. Binciken kyawawan abubuwan rage sukari bai tsaya ba. A cikin shekarun 1950s, masana kimiyya sun yanke hukunci akan kawai biguanides - metformin. An bai wa magungunan sunan Glucophage - mai amfani da sukari.

A ƙarshen 1980s, an gano cewa ɗayan mahimman abubuwan da ke haifar da ciwon sukari shine jure insulin. Bayan wallafa sakamakon binciken masana kimiyya, sha'awar glucophage ya karu sosai. An gudanar da bincike sosai game da tasiri, aminci, hanyoyin magungunan, da yawa na nazarin asibiti. Tun daga 1999, alluna tare da metformin sun zama na farko a cikin jerin shawarar da aka yiwa masu ciwon sukari. Suna wanzuwa a wuri na farko har zuwa yau.

Saboda gaskiyar cewa Glucofage aka ƙirƙira shi shekaru da yawa da suka wuce, sharuɗan kariyar mallaka don shi sun daɗe. Doka ta doka, duk wani kamfanin samar da magunguna na iya samar da metformin. Daruruwan ilimin halittar Glucophage yanzu an sake su a duk duniya, yawancinsu suna ƙarƙashin sunan Metformin. A Rasha, akwai masana'antun kwamfyutoci sama da dozin guda biyu tare da metformin. Kamfanoni waɗanda suka ci amanar marasa lafiya sau da yawa suna ƙara alamar mai ƙira ga sunan miyagun ƙwayoyi. Metformin Canon samfuran Canonfarm Production ne. Kamfanin yana samar da magunguna tsawon shekaru 20. Sun cika cikakkun bukatun duniya da ka'idoji masu inganci. Shirye-shiryen Canonfarm suna shawo kan matakan da yawa, farawa daga albarkatun ƙasa da ake amfani da su, suna ƙarewa da allunan da aka yi. A cewar masu ciwon sukari, Metformin Canon yana kusan kusa da Glucophage na asali dangane da tasiri.

Canonpharma yana samar da metformin a fannoni da yawa:

MagungunaSashiKimanin farashi, rub.
Shafin 30.Shafin 60.
Canform na Canform500103195
850105190
1000125220
Canform Long Canon500111164
750182354
1000243520

Umarnin don shan miyagun ƙwayoyi

Umarni ya jaddada wajabcin lura da tsarin abincin a duk lokacin kulawa da magani. Mai haƙuri yana buƙatar rage yawan ƙwayar carbohydrate (likita ya ƙayyade adadin raguwa la'akari da tsananin cutar), rarraba su a cikin sassan abinci na tsawon ranar. Idan kun kasance kiba, ana shawarar rage yawan adadin kuzari. Mafi karancin adadin kuzari lokacin shan Metformin Canon shine 1000 kcal. Abinci mai tsayayye yana ƙara haɗarin sakamako masu illa.

Idan mai ciwon sukari bai riga ya dauki metformin ba, magani yana farawa ne daga kashi 500-850 MG, kwamfutar hannu tana bugu a cikakkiyar ciki kafin lokacin kwanciya. A farko, haɗarin sakamako masu illa yana da yawa musamman, don haka ba a kara adadin zuwa sati 2. Bayan wannan lokacin, kimanta matakin rage yawan ƙwayar cutar glycemia kuma, idan ya cancanta, ƙara sashi. Kowane makonni 2 zaka iya ƙarawa daga 500 zuwa 850 MG.

Yawancin admission - sau 2-3 a rana, yayin da ɗayan liyafar ta kasance maraice. Dangane da sake dubawa, ga yawancin marasa lafiya, daidaituwa na glycemia ya isa 1500-2000 mg kowace rana (3x500 mg ko 2x850 mg). Matsakaicin adadin da umarnin ya bayar shine 3000 MG (3x1000 MG) ga manya, 2000 MG ga yara, 1000 MG ga marasa lafiya da gazawar renal.

Idan mai haƙuri ya bi abinci, yana ɗaukar metformin a gwargwadon ƙwayar cuta, amma ba ya iya samun nasarar biyan diyya ga masu ciwon sukari, likitan na iya ba da shawarar raguwa mai mahimmanci a cikin kwayar insulin. Idan aka tabbatar da ƙarancin insulin, magungunan hana ƙwaƙwalwar ƙwayar cuta da ke motsa ƙwayar ƙwayoyin cuta an kuma tsara su.

Abin da sakamako masu illa na iya zama

A cikin mucosa na hanji, maida hankali na metformin sau ɗari sau da yawa fiye da jini, hanta da kodan. Yawancin sakamako masu illa na miyagun ƙwayoyi suna da alaƙa da wannan. Kimanin 20% na marasa lafiya a farkon shan Metformin Canon suna da raunin narkewa: tashin zuciya da gudawa. A mafi yawan lokuta, jiki yana kulawa don daidaitawa da miyagun ƙwayoyi, kuma waɗannan alamun suna ɓacewa akan kansu a cikin makonni 2. Don rage tsananin tasirin sakamako, umarnin don amfani da shawarar shan magani tare da abinci, fara magani tare da ƙaramin abu.

Game da haƙuri mai haƙuri, an shawarci likitoci su canza zuwa allunan Metformin da aka yi ta amfani da sabuwar fasaha. Suna da tsari na musamman, godiya ga wanda abu mai aiki ya shiga jini daidai a cikin kananan rabo. A wannan yanayin, haƙurin maganin yana inganta sosai. Allunanda ake amfani da allunan tsufa masu tasirin zamani sune ake kira Metformin Long Canon. Dangane da sake dubawa, sun kasance babban madadin magani na Metformin Canon tare da rashin haƙuri.

Bayanai game da yawan tasirin sakamako daga umarnin:

Rashin Cutar Tasirin MetforminMitar abin da ya faru,%
Lactic acidosis1
Rashin narkewa> 10
Allergic halayenDon kawai 147 rubles!

Contraindications

Yawancin contraindications a cikin umarnin don amfani sune ƙoƙari ne na masana'anta don hana acidosis lactic. Ba za a iya tsara Metformin ba:

  • idan mai haƙuri yana da gazawar renal da GFR tare da ƙasa da 45,
  • tare da matsanancin hypoxia, wanda cututtukan huhu na iya haifar, cututtukan zuciya, tashin zuciya, anemia,
  • tare da gazawar hanta,
  • Al'adun giya
  • idan mai ciwon sukari a baya yana da lactic acidosis, koda kuwa metformin bai haifar dashi ba,
  • yayin daukar ciki, ana ba da izinin insulin ne kawai daga magungunan hypoglycemic a wannan lokacin.

An soke magungunan tare da ketoacidosis, yayin kulawa da cututtukan ƙwayar cuta, raunin da ya faru, kawar da rashin ruwa, kafin ayyukan tiyata. An daina amfani da Metformin kwanaki 2 kafin a yi amfani da X-ray tare da wakili na bambanci, kuma ana sake amfani da maganin bayan kwana 2 bayan binciken.

Raunin ciwon sukari da aka dade ana fama dashi shine ciwon zuciya. A cikin umarnin, wannan cutar tana nufin contraindications zuwa magani tare da metformin, amma a aikace, likitoci dole ne su ba da magani ga irin wannan marasa lafiya. Dangane da binciken farko, metformin a cikin marasa lafiya da ke fama da cututtukan zuciya ba wai kawai yana inganta diyya na ciwon sukari ba, amma yana rage mace-mace da sauƙaƙa yanayin gaba ɗaya. Hadarin lactic acidosis a wannan yanayin yana ƙaruwa kaɗan. Idan aka tabbatar da wannan matakin, to za a cire lalacewar zuciya daga cikin jerin abubuwan da ke hana haihuwa.

Tsarin Saki

Ana samar da miyagun ƙwayoyi a cikin magunguna daban-daban, kuma ɗayansu shine 850 MG. Ana samun umarnin "Metformin Canon" a cikin kowane fakitin. Ana yin kayan aiki a cikin nau'i na biconvex allunan kwalaji, waɗanda suke da farin launi.

Tasirin magunguna

Magungunan da ake tambaya shine wakili na hypoglycemic, wanda ake magana da shi a matsayin biguanides. Zai iya tarawa a cikin hanta, a kodan da kuma a cikin ƙwayoyin hancin haɗi. Amfani da wannan magani yana da alaƙa kai tsaye da ikon hana gluconeogenesis. Ingancirsa shine ya haifar da samuwar acidsanyun acid da hadawar hada hada-hadar kitse, wanda ke shafar tasirin magungunan:

  • Rage matakan sukari.
  • Sensara ji daɗin insulin mai karɓar insulin tare da ingantaccen ɗaukar sukari, hadawar abu da iskar shaka da amfani da glucose.
  • Rage yawan shan kwayoyin horarwa da hawan jini daga tsarin narkewar abinci.
  • Choananan cholesterol, triglyceride da ƙarancin lipoprotein mai yawa.
  • Tsarin daidaituwa tsakanin coagulation na jini tare da haɓaka halayensa na gado, wanda ke rage haɗarin cutar jini.
  • Rage nauyi a matsayin wani ɓangare na lura da kiba.

Umarni na musamman

Dangane da umarnin Metformin Canon, 850 MG, lokacin amfani da wannan miyagun ƙwayoyi, sarrafa glucose bayan abinci da kan komai a ciki yana da matukar muhimmanci, tare da saka idanu na yau da kullun game da ƙwaƙwalwar creatinine (tare da kiyaye ayyukan koda sau ɗaya a shekara, kuma ga tsofaffi tare da rage yarda sau hudu a cikin watanni goma sha biyu). Idan akwai jin zafi a cikin tsokoki da ciki, amai da rauni a cikin jiki, a kan asalin malaise (alamun cututtukan lactic acidosis), kuma, ƙari, tare da alamun cututtukan cututtukan ƙwayar cuta ko cututtukan huhu, ya kamata ku daina shan kwayoyin, sannan ku nemi likita.

Lokacin amfani da miyagun ƙwayoyi tare da sauran jamiái na hypoglycemic, ikon da sauri psychomotor dauki rage. A lokacin da ake shan magani, yakamata mutum ya dena shan giya domin gujewa faruwar cutar lactic acidosis. Magungunan suna contraindicated lokacin daukar ciki, a kan asalin lactation, an dakatar da ciyar da ɗabi'a idan har akwai buƙatar amfani da "Metformin Canon". Don asarar nauyi, ana amfani da wannan maganin sau da yawa.

Rage kilo tare da wuce kima nauyi ne mai wahala a wajen sha'anin tunani da na ilimin halittar jiki, saboda yana bukatar matukar kokari da kuma manyan canje-canje a yanayin rayuwar yau da kullun. A wannan batun, ba wai kawai masana ilimin abinci ba, amma kai tsaye waɗanda suke so su rasa nauyi, suna yin kullun don bincika hanyoyi mafi sauƙi don daidaita nauyin jiki. A cikin 'yan shekarun nan, ya zama sananne don amfani da kwayoyi don rage nauyin magungunan da ba a yi niyya don asarar nauyi ba, amma suna nuna irin waɗannan sakamakon a cikin maganin cututtukan da ke tattare da cutar.

Daya daga cikin wadannan kwayoyi shine Metformin Canon. Likitocin ne ke ba da maganin wa annan magungunan don rage matakan glucose a gaban masu ciwon suga. 'Yan wasan motsa jiki da masu motsa jiki sune farkon waɗanda suka fara amfani da Metformin Canon don asarar nauyi. Furtherarin cigaba, bayan da aka sake samun ingantattun ra'ayoyi masu inganci, ƙwayar ta fara wuce nesa da wasanni da da'irar likita.

Don haka, a cikin yaki da kiba tare da ciwon sukari, ƙwayoyi suna rage matakan glucose, wanda ke kawar da yawan cin abinci tare da sha'awar masu ɗaci. 'Yan wasa da' yan mata a kan abincin da ba su da ciwon sukari suna amfani da magani sau uku a rana don milligram 500 na kwanaki ashirin da biyu (bayan wannan kuna buƙatar hutu har tsawon wata ɗaya).Lokacin ɗauka, ana buƙatar aiki na jiki tare da warewar abinci na carbohydrate da mai mai yawa daga abincin.

Hulɗa da ƙwayoyi

Kamar yadda aka nuna ta hanyar umarnin Metformin Canon, 850 MG, an contraindicated don amfani da waɗannan Allunan kwana biyu kafin da bayan binciken ta amfani da magani na radiopaque. Akwai kwayoyi waɗanda dole ne a yi amfani dasu tare da maganin da muka bayyana a hankali:

  • Wannan, da farko, Danazol, wanda ke kara yiwuwar tasirin hyperglycemic.
  • "Chlorpromazine" a cikin manyan allurai (milligrams 100 a kowace rana) da magungunan antihypertensive suna kara yawan glucose a cikin jini. "Chlorpromazine" yana rage sakin insulin.
  • A wasu misalai, ana amfani da ketosis ta hanyar glucocorticosteroids, haƙurin glucose yana raguwa kuma haɗuwarsa yana ƙaruwa.
  • Atuwar dila na haɓaka haɗarin ci gaban alamun lactic acidosis.
  • Inje na adrenomimetics suna rage tasirin hypoglycemic.
  • Abubuwan da suka samo asali na insulin, sulfonylurea, acarbose da salicylate suna ƙaruwa da tasirin hypoglycemic.
  • "Nifedipine" yana haɓaka ƙwayar metformin.

Alamu don alƙawari

Magungunan "Metformin Canon" an wajabta shi ga masu ciwon sukari na manya tare da nau'in cuta ta biyu a cikin haɗarin cewa salon gyara (abinci mai ƙarancin abinci tare da isasshen motsa jiki, sarrafa yanayin motsin rai) ba ya samar da cikakken ikon sarrafa glycemic.

Ga marasa lafiya masu kiba, Metformin shine mafi kyawun zaɓi. Za'a iya haɗu da wannan magani tare da magungunan hypoglycemic na sauran nau'ikan magungunan, wanda tsarin aikin ya bambanta da biguanides. Hada magani tare da insulin shima hakan zai yiwu.

Hakanan an wajabta magungunan don magance nau'in ciwon sukari na II a cikin yara waɗanda suka girmi shekaru goma. Ana amfani dashi azaman magani na farko-layi ɗaya ko a hade tare da insulin. Bodybuilders suna amfani da wannan magani don bushe tsokoki, kuma 'yan mata da ke da nauyin nauyi suna yin gwaji, amma irin wannan amfani yana barata ne kawai lokacin da nauyin nauyin wuce haddi yana haɗuwa da juriya na insulin da gazawar matakai na rayuwa.

Side effects

Dangane da umarnin da kuma sake dubawa na Metformin Canon, 850 MG, a cikin manya da yara, tasirin sakamako na shan maganin iri ɗaya ne. Akwai ɗanɗano da ƙarfe a cikin bakin tare tare da tsarin narkewa kamar haɓaka ta rashin abinci, tashin zuciya, ciwon ciki, zawo da amai. Ana nuna alamar aikin hanta, hepatitis na faruwa. Harkokin halayen kamar B12 hypovitaminosis tare da bayyanar rashin lafiyan (ƙoshin fatar, fatar, erythema, urticaria) ga miyagun ƙwayoyi suna da wuya.

Yawan abin sama da ya kamata

Ya kamata a sha wannan magani kawai a cikin kashin da aka tsara, in ba haka ba za'a iya samun haɗarin yawan zubar da ruwa. Samun Metformin, daidai yake da gram 85, na iya haifar da ci gaban lactic acidosis, wanda zai iya haɗuwa da ciwon tsoka, kuma, ƙari, rashin jin daɗi a ciki, tashin zuciya da amai. A cikin abin da ya faru ba a ba da taimako ta hanyar da ta dace, to yawan shan wannan magungunan na iya haifar da rashin jin daɗi, lalacewar kwakwalwa da kuma cutar ciki. Yanzu mun juya ga contraindications kuma gano lokacin da marasa lafiya bai kamata su ɗauki wannan magani don magani ba.

Janar halaye na miyagun ƙwayoyi

Abun da ke tattare da wakilin antidiabetic Metformin Canon ya hada da metformin hydrochloride, sananne ne a cikin duniya wanda zai iya rage matakan sukari a cikin masu ciwon sukari.

Baya ga wannan bangaren, shirye-shiryen sun ƙunshi ƙaramin adadin sodium stearyl fumarate, sitaci, titanium dioxide, talc, macrogol da sauran abubuwan haɗin.

Wanda ya kirkiro wakilin din din din shine babban kamfanin hada magunguna na gida Canonfarm Production.

Kamfanin yana samar da magani a cikin nau'ikan allunan (fari, biconvex) a cikin magunguna daban-daban:

  1. Metformin Canon 500 MG.
  2. Metformin Canon 850 MG.
  3. Metformin Canon 1000 mg.

An ba da izinin maganin daga shekaru 10, ba wai a matsayin monotherapy ba, har ma a hade tare da injections na insulin. Lokacin da aka shiga ciki, ana amfani da metformin a cikin narkewa, kuma mafi girman abincinta ana samun shi kimanin awa 2-2.5 bayan fitowar. An aiwatar da aikin hypoglycemic:

  • don hana samuwar glucose daga mahallin da ba a carbohydrate a cikin hanta ba,
  • don raunana sha da glucose a cikin narkewa,
  • don ƙara yawan yiwuwar ƙwaƙƙwaran ƙwayoyin cuta zuwa hormone mai rage sukari,
  • don cire glucose daga kyallen,
  • don tayar da glycogenesis na ciki,
  • a kan kunnawa na glycogen synthase,
  • a tsaftace liwadi metabolism.

Bugu da ƙari, ƙwayar tana da wasu tasirin fibrinolytic. Metformin Canon zai iya daidaitawa da rage nauyin jiki mai yawa. Ya bambanta da shirye-shiryen abubuwan samo asali na sulfonylurea a cikin cewa ba ya haifar da ƙarin samar da insulin kuma baya haifar da saurin rage sukari a cikin mutane masu lafiya.

Abubuwan da ke gudana suna yadawa da sauri cikin kyallen takarda. Yana iya tarawa a cikin hanta, gyada mai ƙonewa da kodan.

Metformin a zahiri ba metabolized ba ne, saboda haka kodan ya raba shi da kusan sigar canzawa.

Umarnin don amfani da allunan

Koda bayan tattaunawa tare da likitanku bayan siyan magani, umarnin don amfani dashi ya kamata a yi nazari a hankali. Idan kuna da wasu tambayoyi tare da mai haƙuri, ya kamata ku nemi shawarar likita.

Allunan suna bada shawarar sosai don amfani lokacin cin abinci ko. Ba a tarar da su, amma an hadiye su da gilashin ruwa. Bayanin maganin yana cewa maganin farko na manya shine 1000-1500 MG kowace rana. A wannan yanayin, yana da kyawawa don raba kashi sau da yawa a rana. Wannan shawarwarin ya kasance ne saboda gaskiyar cewa yayin daidaitawar jiki zuwa aikin metformin, wasu sakamako masu illa suna faruwa, galibi yana haɗuwa da tsarin narkewar abinci. Mai ciwon sukari na iya yin gunaguni na amai, gudawa, canji na ɗanɗano, zafin ciki, da rashin jin daɗi. Koyaya, bayan kwanaki 10-14, waɗannan halayen suna tafiya da kansu.

Bayan jiki ya saba da metformin, likita zai iya ƙara yawan sashi na hypoglycemic wakili dangane da matakin sukari na haƙuri. Ana daukar kashi na kulawa kamar 1500 zuwa 2000 MG kowace rana. Matsakaicin wanda aka yarda da shi yau da kullun shine 3000 MG.

Idan mai haƙuri ya canza zuwa Metformin Canon tare da wasu maganin ƙwaƙwalwar ƙwayar cuta, dole ne ya dakatar da ɗayan. Lokacin haɗuwa da miyagun ƙwayoyi tare da maganin insulin, ana ba da shawarar a farkon jiyya don ɗaukar 500 ko 850 mg biyu zuwa sau uku a rana. Ana ɗaukar ƙwayar Metformin 1000 a sau ɗaya a rana.

Yaran da suka kai shekaru 10 na iya fara magani tare da 500 MG na miyagun ƙwayoyi. Yana da kyau a ci da yamma yayin cin abinci. Bayan kwanaki 10-14, likita zai iya kara yawan abincin yau da kullun zuwa 1000-1500 MG. An ba wa yaron damar ɗaukar kimanin 2000 MG a kowace rana.

Tsofaffi masu ciwon sukari sun cancanci kulawa ta musamman. Dosins da tsawon lokacin likita ana zaɓa su daban-daban. Sama da shekaru 60, wani ƙwaƙwalwar ƙwayar cuta zai iya haifar da lalata koda.

Ya kamata a lura cewa ba za a iya siyan magungunan ba tare da takardar sayen magani na likita ba. Dole ne a kiyaye matakalin Metformin Canon din daga isarwar hasken rana da zafi. Yawan zazzabi kada ya wuce digiri 25 na Celsius.

Bayan ranar karewa, wanda shine shekaru 2, an hana gudanar da wakilin maganin cututtukan fata.

Sauran mu'amala da miyagun ƙwayoyi

Kamar yadda kuka sani, wasu kwayoyi na iya samun tasirin sakamako kai tsaye akan aikin Metformin Canon, rage ko kara tasirin hypoglycemic.

Umarnin ya ce haɓakar contraindicated shine amfani da abubuwan kwatancin aidin.

A kan asalin lalacewar koda ko a cikin marasa lafiya, suna iya haifar da ci gaban lactic acidosis. Hakanan ba lallai ba ne a haɗa giya, abubuwan madauki da shirye-shiryen da ke ɗauke da ethanol tare da yin amfani da metformin.

Ana buƙatar musamman musamman ta hanyar magunguna waɗanda zasu iya raunana aikin metformin kuma suna haifar da hauhawar jini. Wadannan sun hada da:

  1. Danazole
  2. Chlorpromazine.
  3. Kwayarwa.
  4. Glucocortecosteroids.
  5. Beta2-adrenergic agonists.

Angiotensin-canza masu hana enzyme, injections insulin, salicylates, acarbose da abubuwan sulfonylureas na iya haɓaka tasirin hypoglycemic na metformin.

Dole ne a yi la’akari da cewa tare da gudanar da daidaituwa na nifedipine da metformin, hypoglycemia na iya faruwa a cikin ciwon sukari na mellitus. Don hana ci gaban lalacewa na koda, ya zama dole a yi amfani da NSAIDs tare da taka tsantsan.

A kowane hali, lokacin yanke shawara don amfani da kowane kwayoyi, da farko, ya zama dole a nemi shawara tare da likitanka. Boye bayanan cuta daga likita na iya haifar da sakamako wanda ba zai yiwu ba.

Farashi da magunguna

An bawa kowane mara lafiya damar sayen wannan magani a cikin kantin magani ko cike aikace-aikacen sayan ta hanyar gidan yanar gizon jami'anta.

Mai yiwuwa mai siyarwa ya mayar da hankali ba kawai kan tasirin warkewar magani ba, har ma da tsadarsa. Ya kamata a lura cewa Metformin Canon yana da ƙananan farashi.

Saboda haka, kowane haƙuri zai iya samun magani.

Kudinsa ya dogara da nau'in saki da adadin allunan a cikin kunshin:

  • Metformin Canon 500 MG (Allunan 30) - daga 94 zuwa 110 rubles,
  • Metformin Canon 850 MG (Allunan 30) - 112 zuwa 116,
  • Metformin Canon 1000 MG (allunan 30) - daga 117 zuwa 165 rubles.

A tsakanin likitoci da marasa lafiya, zaku iya samun maganganu masu yawa game da amfani da wannan magani. Don haka, masu ciwon sukari lura cewa Metformin Canon yana daidaita matakan glucose ba tare da haifar da hypoglycemia ba. Har ila yau, sake dubawa na nuna asarar nauyi a cikin mutane masu kiba. Sabili da haka, daga cikin fa'idodin maganin za a iya gano inganci, sauƙi na amfani da ƙarancin farashi.

Negativeangaren mara kyau na amfani da wannan magani ana ɗauka azaman halayen da ba a sani ba waɗanda ke faruwa a cikin martani game da aikin metformin - narkewa cikin damuwa. Amma yayin rarrabuwa da matakan yau da kullun zuwa allurai da yawa, irin waɗannan alamun suna raguwa sosai.

Yawancin marasa lafiya waɗanda suka ɗauki Metformin Canon sun sake tunawa cewa magani tare da miyagun ƙwayoyi an “rushe shi” idan ba ku bi maganin wariyar abinci ba, kar ku shiga cikin wasanni kuma kar ku kula da matakan sukari kowace rana.

Irin kwayoyi

Wasu lokuta yin amfani da miyagun ƙwayoyi ya zama ba zai yiwu ba saboda dalilai daban-daban, ko dai contraindications ko halayen m.

A irin waɗannan halayen, duk alhakin ya rataya ne tare da likita, wanda ya yanke shawarar canza maganin. A wannan yanayin, dole ne yayi la’akari da matakin sukari a cikin jinin mai haƙuri da kuma yanayin lafiyar sa gaba ɗaya.

Irin waɗannan magunguna suna da irin wannan sakamako na warkewa, amma sun bambanta a cikin tsarin su.

Metformin wani shahararren magani ne wanda ake amfani dashi don daidaita matakan glucose. A wannan batun, ana amfani dashi azaman aiki mai aiki na yawancin wakilai na hypoglycemic.

Daga cikin sanannen analogues na Metformin Canon ya bambanta:

  1. Gliformin wani ingantaccen magani ne na antidiabetic wanda aka yi amfani dashi don rashin maganin sulfonylureas. Godiya ga tsarin metformin, yana taimakawa rage nauyi a cikin mutanen da suke masu kiba. Matsakaicin matsakaicinta ya dogara da nau'in saki: 500 mg -106 rubles, 850 mg -186 da 1000 mg - 368 rubles.
  2. Glucophage wani magani ne wanda ke na ƙungiyar biguanide. Ya wanzu ta hanyar tsawaita aiki (Glucophage Long). Hakanan ana amfani dashi don maganin da ke fama da insulin. Matsakaicin farashin kunshin guda ɗaya daga 107 zuwa 315 rubles.
  3. Siofor 1000 magani ne da aka yi amfani da shi don rigakafi da magani ga cututtukan siga, har ma da asarar nauyi. A matsakaici, farashin ya bambanta daga 246 zuwa 420 rubles, saboda haka ba za a iya kiran shi analogue mai ƙarancin kuɗi ba.
  4. Metformin-Teva magani ne wanda ake amfani dashi don ciwon sukari na 2, lokacin da abinci da motsa jiki suka zama marasa tasiri. Kamar Metformin Canon, yana daidaita glycemia, metabolism na lipid da nauyin jikin mai haƙuri. Matsakaicin farashin magani shine daga 125 zuwa 260 rubles.

Akwai wasu magunguna da yawa waɗanda ke da irin wannan tasirin akan Metformin Canon. Ana iya samun cikakken bayani game da su ta amfani da Intanet ko ta tambayar likitanka.

Metformin Canon magani ne mai inganci na maganin cututtukan cututtukan zuciya. Tare da yin amfani da shi yadda yakamata, zaku iya kawar da alamun “cutar mai daɗi” ku zauna lafiya tare da mutane masu lafiya. Koyaya, yayin amfani da miyagun ƙwayoyi, dole ne a bi duk umarnin likita, don kada ku cutar da kanku.

Kwararrun daga bidiyo a wannan labarin zasuyi magana game da Metformin.

Mene ne Metformin

Matsakaicin matsayi a cikin lura da nau'in ciwon sukari na 2 na mellitus ya ɗauki Metformin. Ya kasance na biguanides. Waɗannan abubuwa ne masu rage jini. An tabbatar da ingancin ƙwayar ta lokaci, aiwatar da amfani, kamar yadda aka tabbatar ta hanyar bita da haƙuri. Wannan ita ce kawai magani da ake amfani da shi don kula da ciwon sukari a cikin yara. Metformin yana da sunaye da yawa, ana siyar dashi kamar Glucofage, Siofor, Gliformin. Ya dogara da masana'anta da abun da ke cikin magunguna.

Abun ciki da nau'i na saki

Ana samun Metformin a cikin kwamfutar hannu. Suna zagaye, biconvex, an rufe shi da harsashi mai launin farin launi. An tattara maganin a cikin blisters na 10 ko 15. Kwandon kati zai riƙe allunan 30. Tebur yana nuna abun da ke ciki na maganin kafeyin ƙwayoyi ɗaya:

Mai aiki da hankali

Metformin hydrochloride (ko dimethylbiguanide)

Tashin masara (ko dankalin turawa)

Yadda ake ɗauka

Allunan an cinye Allunan, an wanke su da ruwa mai yawa. Minimumarancin mafi ƙarancin farko shine 500 MG sau ɗaya a rana, matsakaicin shine 2.5-3 g. Ana bada shawara don ɗaukar allunan tabarau bayan abincin dare ko kai tsaye kafin lokacin bacci. Sashi na miyagun ƙwayoyi ya fi kyau a ƙara hankali. Babban adadin farko na dimethylbiguanide yana haifar da lalata ciki kuma yana rushe tsarin narkewa. Wani ɗanɗano mai ƙarfe, tashin zuciya alamomi ne na yawan wuce gona da iri a farkon matakan amfani da samfurin kantin magani.

Tare da monotherapy tare da magani, yana da kyau a bi tsarin da aka tabbatar:

  1. A cikin makon farko, ana ɗaukar magani a cikin adadin 500 MG sau 1.
  2. Gaba, kashi na yau da kullun yana ƙaruwa zuwa 850-1000 MG kuma ya kasu kashi biyu.
  3. Idan tafiyar matakai na rayuwa ba su gamsuwa da matsakaicin adadin 2000 mg, ya kamata a kara sulfonylureas zuwa metformin ko insulin ya kamata a yi amfani da shi.
  4. Increasearuwar sashi ya dogara da karatun glucose. Likita ne aka zazzage allurai ta hanyar likita.
  5. A cikin marasa lafiya tsofaffi, matsakaicin adadin yau da kullun shine 1000 mg.

Yanayin ajiya da siyarwa

Ana fitar da maganin ne kawai ta hanyar takardar sayan magani. Rayuwar shiryayye na wannan samfurin shine shekara biyu, a ƙarshen abin da aka haramta amfani da wannan magani. Ya kamata a adana magungunan a wuri mai kariya daga haske, wanda ya kamata ya bushe, a zazzabi da bai wuce digiri ashirin ba.

Farashin Allunan 60 na "Metformin Canon" 850 MG - kusan 200 rubles.

Bayan haka, mun gano abin da mutane suke rubuta game da wannan magani, kuma, ƙari, za mu san ra'ayin ra'ayoyin likitoci game da tasiri na miyagun ƙwayoyi da ake tambaya.

Da farko, la'akari da sake dubawa game da "Metformin Canon" 850 MG daga marasa lafiya.

Sharhi mai haƙuri

A cikin sake dubawa, marasa lafiya sun tabbatar da tasiri na maganin a cikin tambaya a matsayin wani ɓangare na maganin cututtukan cututtukan cututtukan fata kuma a matsayin hanya don rasa kilo da ba a so.Dangane da sake dubawar mabukaci, Metformin Canon magani ne mai araha da inganci, da farko dangane da sarrafa glucose, da kuma nauyin jikin mutum. Daga cikin manyan rashi, bayyanar cututtukan sakamako daga tsarin narkewa ana yawan ambata sosai.

Likitoci suna bita

A cikin sake duba su game da "Metformin Canon" 850 MG, masana sun tabbatar da ikon wannan magani. Amma sun yi gargaɗi cewa ya kamata a gudanar da aikin yau da kullun game da maida hankali kan ƙwayar glucose.

Zai fi kyau sanin kanku da sake dubawar likitoci game da Metformin Canon a gaba.

Likitoci sun rubuta cewa yayin shan wannan magani, zazzabi mai zafi, rauni gaba ɗaya, jin zafi a cikin tsokoki ko ciki tare da amai na iya faruwa. A duk waɗannan halayen, marasa lafiya ya kamata su nemi likita, saboda irin waɗannan bayyanar cututtuka na iya nuna ci gaban lactic acidosis.

Bugu da kari, likitoci a bita na Metformin Canon suna ba da taka tsantsan a lokuta na aikin nakasa, alal misali, a farkon farfajiyar magungunan da ba su da steroid ba. Kwararru suna ba da shawarar marasa lafiya tare da likita a kan asalin ci gaban bayyanar cututtuka na cututtukan cututtukan cututtukan ƙwayar cuta ko kamuwa da cuta na bronchopulmonary.

Canform Long Canon

Wannan magani yana aiki azaman wakili na hypoglycemic wakili daga sashen biguanides. Hanyar aiwatarwa yana da alaƙa da ikon ƙwayar don rage gluconeogenesis tare da ƙirƙirar ƙwayoyin mai mai kyauta. Magungunan yana ƙaruwa mai karɓa na insulin na insulin. Yana da mahimmanci a lura cewa Metformin Long Canon baya tasiri yawan insulin a cikin jini, amma yana canza magunguna.

Magungunan yana motsa glycogen synthesis. Thearfin jigilar kowane nau'ikan jigilar mahaifa yana ƙaruwa. Magunguna, a tsakanin wasu abubuwa, yana jinkirta shan glucose a cikin hanji, yana rage matakin triglycerides, kuma yana inganta kayan jini na fibrinolytic. A waje da asalin amfani da wannan magani, nauyin jikin mai haƙuri ya kasance mai tsayayye ko kuma zai iya raguwa a ɗan lokaci.

Alamu don amfani da tsawan magani

Babban nuni shine ciwon sukari na 2 a cikin manya (musamman a tsakanin marassa lafiyar da ke kiba), da cewa motsa jiki da aikin abinci ba su da tasiri. A cikin waɗannan halayen, ana sanya maganin a matsayin wani ɓangare na monotherapy kuma a haɗe tare da wasu wakilai na maganadis na maganin haila ko insulin.

Hanyar gudanarwa da kuma doguwar magunguna

Ya kamata masu wannan ciki su sha wannan maganin. Allunan an cinye su, basu ɗanɗana ba kuma an sha su da ruwa mai isasshen ruwa. Zasu iya bugu sau daya bayan ko lokacin abincin dare. Likita ya zaɓi kashi na maganin daban-daban ga wani mai haƙuri dangane da sakamakon ƙididdigar glucose.

Ga marasa lafiya waɗanda ba su ɗauki metformin a baya ba, shawarar farko ta wannan maganin ita ce milligram sau 500 sau ɗaya a rana bayan abincin dare. Kowane kwanaki goma ko goma sha biyar, ana ba da shawarar don daidaita adadin magani bisa ga sakamakon auna haɗarin glucose a cikin jini na jini. Slowara sauƙaƙawa a cikin kashi na so mafi kyawun haƙuri a ɓangaren tsarin narkewa.

Don haka, maganin Metformin Canon, wanda aka yi la’akari da shi a cikin labarin, an inganta shi don magance cututtukan type 2 na marasa lafiyar manya. Amma, kamar yadda aka riga aka sani sau da yawa, a halin yanzu yana samun yaduwa daidai a cikin aikin wata hanya don samun nauyin hanzari mai nauyi kuma wasu lokuta mutane sun nada shi azaman masanin abinci.

Mun sake nazarin umarnin don "Metformin Canon" 850 MG.

Aikin magunguna

Magungunan Magunguna wani wakili ne wanda ya danganta da biguanides kuma yana tattarawa a cikin hanta, gyada mai, da kuma kodan. Ingancin ƙwayar yana da alaƙa da ikon hana gluconeogenesis, samuwar ƙwayoyin mai mai kyauta da hadawar hada hada abubuwa da hada abubuwa da kitse na kitsewanda ke shafar tasirin magungunan magungunan:

  • rage sukari
  • increasedara hankalin masu karɓar insulin, ingantattun shaye-shayen sukari, hada hadarin abu mai ƙoshin acid da kuma yawan amfani da glucose na ƙasa,
  • rage yawan glucose daga narkewa, narkewar ƙwayar hodar kansa ta cikin jini,
  • saukar da sinadarin cholesterol, triglycerides da karancin abinci mai yawa,
  • normalization na coagulability jini, inganta ta rheological Properties, wanda rage hadarin thrombosis,
  • nauyi asara a lura da kiba.

Aikace-aikacen

An wajabta Metformin ga mutanen da ke da nau'in ciwon sukari na 2 na sukari (wanda ba shi da insulin). Jiyya tare da miyagun ƙwayoyi ana bada shawara idan mai haƙuri yana fama da ƙima mai ƙima ko, idan ya cancanta, saka idanu akan abubuwan glucose. An sanya maganin a matsayin monotherapy ko azaman ƙarin magunguna don insulin ko wasu magungunan rigakafin ciwon sukari.

Sashi da gudanarwa

Ana shan maganin a baki yayin abinci ko kuma bayan hakan. Ya kamata a hadiye allunan gaba daya ba tare da taunawa ba. Mitar gudanarwa da kashi na Metformin sun dogara da nau'in magani:

Manya Metformin monotherapy da haɗuwa da magani tare da sauran magunguna na baki hypoglycemic

1000-1500 mg / rana. - kashi na farko na miyagun ƙwayoyi. Zai yuwu a rage tasirin sakamako daga cututtukan gastrointestinal (gastrointestinal fili) ta hanyar rarraba abincin ta hanyar sau 2-3. A cikin rashin sakamako mai illa akan ƙwayar gastrointestinal, bayan kwanaki 10-15, ana iya ƙara yawan ƙwayar a hankali (dangane da glucose).

Mayar da maganin yau da kullun - 1500-2000 mg. Matsakaicin kowace rana - 3000 MG, ya kasu kashi uku.

Sauyawa daga wani magani na baka zuwa magani na sukari Metformin

Fara shan magungunan (sama da allurai) bayan dakatar da amfani da wani magani na hypoglycemic.

Hade jiki tare da insulin

Tare da kashi na farko na 500 MG da 850 MG, ɗauka kwamfutar hannu ɗaya sau 2-3 sau / rana., A 1000 mg - 1 kwamfutar hannu 1 lokaci / rana. An zabi sashin insulin ne bisa yawan karatun glucose.

Yara daga shekaru 10 zuwa 16. Ana amfani da maganin don maganin tauhidi kuma a hade tare da insulin.

Maganin farko shine 500 MG 1 sau ɗaya kowace rana, ana ɗauka da maraice tare da abinci. Bayan kwanaki 10-15, an daidaita rabo gwargwadon ƙimar glucose. 1000-1500 mg / rana., Rarraba ta sau 2-3 - kashi na tabbatarwa. 2000 MG a cikin allurai uku - mafi girma.

Mutane a cikin tsufa

An zaɓi kashi saboda sakamakon saka idanu na yau da kullun na alamun alamun aiki (aƙalla sau 2-4 a shekara).
Likita ya kayyade tsawon lokacin magani.

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