Allunan - 1 kwamfutar hannu:

Abunda yake aiki: metformin hydrochloride 500 mg / 850 mg / 1000 mg,
Mahalarta: hypromellose 2208 5.0 mg / 8.5 mg / 10.0 mg, povidone K90 (collidone 90F) 20.0 mg / 34.0 mg / 40.0 mg, sodium stearyl fumarate 5.0 mg / 8, 5 MG / 10.0 MG
Fim mai narkewa mai ruwa: hypromellose 2910 7.0 mg / 11.9 mg / 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 0.9 mg / 1.53 mg / 1.8 mg, polysorbate 80 (tween 80) 0, 1 mg / 0.17 mg / 0.2 mg, titanium dioxide 2.0 mg / 3.4 mg / 4.0 mg.

Allunan da aka rufe fim din, 500 MG, 850 MG, 1000 MG.

Primary miyagun ƙwayoyi

A kan allunan 10 a cikin marfin ruwan tabarau daga fim na polyvinyl chloride da kuma allon fitilun aluminium da aka buga.

Don 15, 30, 60, 100, 120 Allunan a cikin gilashin polymer da aka yi da polyethylene tare da murfi da aka shimfiɗa tare da ikon buɗewa na farko. Samun sararin samaniya yana cike da auduga na likita. Labarai da aka yi da takarda lakabi ko rubuce-rubuce, ko kayan adadi na polymeric na kai, ana manne da su a bankunan.

Sakandare magungunan sakandare

1, 2, 3, 4, 5, 6, 8, 9, ko 10 fakitoci, tare da umarnin yin amfani da su, an sanya su a cikin kwali na kwali don fakitin mabukaci.

Ana iya amfani da 1 tare da umarnin don amfani a cikin fakitin kwali don fakitin mabukaci.

Allunan kwayoyi 1000 MG: Allunan biconvex Allunan mai rufi tare da farin fim mai rufi tare da haɗari a gefe ɗaya. A bangaran giciye, babban yana da fari ko fari fari.

Wakilin hypoglycemic na rukunin biguanide don amfani da baka.

Ragewa da rarrabawa

Bayan gudanar da baki, ana amfani da metformin daga cikin gastrointestinal fili sosai. Cikakken bioavailability shine 50-60%. Matsakaicin maida hankali (Cmax) (kamar 2 μg / ml ko 15 μmol) a cikin plasma an kai shi bayan sa'o'i 2.5. Tare da shigar abinci abinci a lokaci guda, yawan shan metformin yana raguwa kuma yana jinkirta.

An rarraba Metformin cikin hanzari a cikin nama, kusan ba a ɗaura shi ga furotin plasma ba.

Metabolism da excretion

Yana cikin metabolized sosai ga rauni sosai kuma kodan ya keɓe shi. Tabbatar da metformin a cikin batutuwa masu ƙoshin lafiya shine 400 ml / min (sau 4 fiye da yardawar creatinine), wanda ke nuna kasancewar ƙwayar canalic aiki. Rabin rayuwar shine kimanin awanni 6.5. Tare da gazawar koda, yana ƙaruwa, akwai haɗarin tarin ƙwayoyi.

Metformin yana rage hyperglycemia ba tare da haifar da ci gaban hypoglycemia ba. Sabanin abubuwan da aka samo na sulfonylurea, ba ya tayar da rufin insulin kuma ba shi da tasirin hypoglycemic a cikin mutane masu lafiya. Theara hankalin mai karɓar mahaifa zuwa insulin da kuma amfani da glucose ta sel. Yana rage haɓakar glucose ta hanta ta hanyar hana gluconeogenesis da glycogenolysis. Yana jinkirta ɗaukar ciki na glucose. Metformin yana ƙarfafa haɗin glycogen ta hanyar aiki akan glycogen synthase. Capacityara ƙarfin jigilar kayayyaki na kowane nau'ikan jigilar jini na membrane. Bugu da kari, yana da fa'ida mai tasiri akan metabolism na lipid: yana rage abun cikin jimlar cholesterol, karancin lipoproteins da triglycerides.

Yayin shan metformin, nauyin jikin mai haƙuri ko dai ya kasance tsayayye ko yana raguwa da matsakaici. Nazarin asibiti ya kuma nuna tasiri na metformin don hana kamuwa da cutar sukari a cikin marasa lafiya da masu kamuwa da ciwon suga tare da ƙarin abubuwan haɗari don haɓakar ciwon sukari irin na 2, wanda yanayin canje-canjen rayuwar bai ba da izinin samun isasshen iko na glycemic ba.

Alamu don amfani da Merifatin

Nau'in nau'in ciwon sukari na 2, musamman a cikin marasa lafiya tare da kiba, tare da rashin tasirin maganin abinci da aikin motsa jiki:

A tsofaffi, kamar yadda monotherapy ko a hade tare da sauran wakilai na baka hypoglycemic ko tare da insulin,
a cikin yara daga shekaru 10 a matsayin maganin ƙwaƙwalwar ƙwayar cuta ko a hade tare da insulin. Yin rigakafin kamuwa da ciwon sukari na 2 a cikin marasa lafiya da masu ciwon sukari tare da ƙarin abubuwan haɗari don haɓaka ciwon sukari na type 2, wanda canje-canjen rayuwar ba su ba da izinin isasshen ikon sarrafa haɓaka ba.

Contraindications Merifatin

Hypersensitivity zuwa metformin ko ga wani na da,
mai ciwon sukari ketoacidosis, maganin ciwon sukari, coma,
gazawar koda ko gauraya aiki na keɓaɓɓen aiki (keɓantar da keɓaɓɓen ƙasa da miliyan 45 / min),
mummunan yanayin da ke tattare da haɓakar haɓakar ɗan adam: fitsari (tare da gudawa, amai), cututtukan da ke yaɗuwa, girgiza,
bayyanar cututtuka na asibiti a cikin cututtukan cututtukan ƙwayar cuta ko cututtukan ƙwayar cuta wanda zai iya haifar da ci gaban hypoxia na nama (ciki har da ƙarancin zuciya, gazawar zuciya tare da rashin ƙarfi a cikin jijiyoyin jiki, gazawar numfashi, raunin myocardial infarction),
babban tiyata da rauni yayin da aka nuna insulin,
hanta hanta, gazawar hanta,
na kullum barasa, guba mai guba,
ciki
lactic acidosis (gami da tarihi),
aikace-aikacen ƙasa da awanni 48 kafin da a tsakanin awanni 48 bayan gudanar da karatun radioisotope ko raayoyi tare da gabatarwar iodine-dauke da matsakaici,
bijiro da tsarin yawan hypocaloric (ƙasa da 1000 kcal / rana).

Yi amfani da hankali da magani:

a cikin mutanen da suka manyanta 60 waɗanda suke yin aiki na zahiri, waɗanda ke da alaƙa da haɓakar haɓakar lactic acidosis,
a cikin marasa lafiya da gazawar renal (keɓaɓɓen karɓar ƙirar 45-59 ml / min),
yayin shayarwa.

Amfani da Merifatin a cikin ciki da yara

Rashin daidaituwa na ciwon sukari mellitus a lokacin daukar ciki yana da alaƙa da haɓakar haɗarin rashin lahani na haihuwa da mutuwar haihuwa. Limitedarancin adadin bayanai sun nuna cewa shan metformin a cikin mata masu ciki baya ƙara haɗarin haɓakar nakasar haihuwar yara.

Lokacin da ake shirin yin juna biyu, haka kuma yayin da ake yin ciki a bango na shan metformin tare da ciwon suga da nau'in ciwon sukari na 2, yakamata a dakatar da maganin, kuma idan akwai nau'in ciwon sukari na 2, an wajabta maganin kansa. Wajibi ne a kula da abubuwan glucose a cikin jini na jini a matakin kusa da na al'ada don rage hadarin cutar tayin.

Metformin yakan shiga cikin madarar nono. Ba a lura da sakamako masu illa a cikin jarirai yayin shayarwa yayin shan metformin. Koyaya, saboda iyakance adadin bayanai, ba da shawarar amfani da miyagun ƙwayoyi lokacin shayarwa ba. Dole ne a yanke shawarar dakatar da shayarwa ta la'akari da amfanin shayarwa da kuma haɗarin haɗarin sakamako masu illa ga jariri.

Nau'i na saki, marufi da abun da ke ciki

Allunan, an shafe su tare da farin fim mai kauri, suna da yawa, biconvex, tare da haɗari a gefe guda, a sashin giciye ainihin farin fari ko kusan fararen launi.

Shafin 1
metformin hydrochloride	1000 mg

Fitowa: hypromellose 2208 - 10 MG, povidone K90 (collidone 90F) - 40 MG, sodium stearyl fumarate - 10 MG.

Fim-mai narkewa mai ruwa: hypromellose 2910 - 14 MG, polyethylene glycol 6000 (macrogol 6000) - 1.8 MG, polysorbate 80 (tween 80) - 0.2 mg, titanium dioxide - 4 mg.

10 inji mai kwakwalwa. - fakitin bakin (1) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin (2) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakiti mai bakin ciki (3) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakiti mai bakin ciki (4) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin ciki (5) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin (6) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin ciki (7) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin ciki (8) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakitin bakin (9) - fakitoci na kwali.
10 inji mai kwakwalwa. - fakiti mai bakin ciki (10) - fakitoci na kwali.
Guda 15. - gwangwani (1) - fakitoci na kwali.
30 inji mai kwakwalwa - gwangwani (1) - fakitoci na kwali.
60 inji mai kwakwalwa. - gwangwani (1) - fakitoci na kwali.
Guda 100 - gwangwani (1) - fakitoci na kwali.
Guda 120 - gwangwani (1) - fakitoci na kwali.

Aikin magunguna

Wakili hypoglycemic wakili daga rukuni na biguanides (dimethylbiguanide). Hanyar aiwatar da metformin yana da alaƙa da iyawarta don dakatar da gluconeogenesis, kazalika da samuwar ƙwayoyin mai mai kyauta da hadawar hada hada abubuwa da hada abubuwa da kitse na kitse. Theara hankalin mai karɓar mahaifa zuwa insulin da kuma amfani da glucose ta sel. Metformin baya tasiri da yawan insulin a cikin jini, amma yana canza magunguna ta hanyar rage ragin insulin da za'a ɗauka kyauta da kuma ƙara yawan rabo daga insulin zuwa proinsulin.

Metformin yana ƙarfafa haɗin glycogen ta hanyar yin aiki akan glycogen synthetase. Capacityara ƙarfin jigilar kayayyaki na kowane nau'ikan jigilar jini na membrane. Yana jinkirta ɗaukar ciki na glucose.

Yana rage matakin triglycerides, LDL, VLDL. Metformin yana haɓaka ƙirar fibrinolytic ta jini ta hanyar dakatar da nau'in mai kunnawa mai hana jini plasminogen.

Yayin shan metformin, nauyin jikin mai haƙuri ko dai ya kasance tsayayye ko yana raguwa da matsakaici.

Pharmacokinetics

Bayan gudanar da baki, metformin yana hankali kuma yana cika aiki daga narkewa. C max a cikin jini yana isa bayan kimanin awa 2.5. Tare da kashi ɗaya na 500 MG, cikakken bioavailability shine 50-60%. Tare da shigowa na lokaci daya, shakar metformin zai ragu kuma yana jinkirta.

An rarraba Metformin cikin hanzari zuwa ƙwayar jikin mutum. A zahiri ba a ɗaura shi da sunadaran plasma. Yana tarawa a cikin glandan ciki, hanta da ƙodan.

Kallonta yayi ya fice da ita. T 1/2 daga plasma shine 2-6 hours.

Idan akwai rauni na aiki na koda, tarawar metformin mai yiwuwa ne.

Alamar magunguna

Nau'in 2 na ciwon sukari mellitus (rashin insulin-dogara) tare da maganin rage cin abinci da motsa jiki na rashin ƙarfi, a cikin marasa lafiya tare da kiba: a cikin manya - kamar monotherapy ko a hade tare da wasu wakilai na bakin jini ko tare da insulin, a cikin yara masu shekaru 10 da mazan - kamar monotherapy ko a hade tare da insulin.

Lambobin ICD-10

Lambar ICD-10	Nuna
E11	Type 2 ciwon sukari

Sakawa lokacin

Ana ɗauka ta baki, lokacin ko bayan abinci.

Matsayi da mita na gudanarwa ya dogara da nau'in sashi wanda aka yi amfani dashi.

Tare da monotherapy, kashi ɗaya na farko na manya shine 500 MG, ya dogara da nau'in sashi wanda aka yi amfani dashi, yawan gudanarwa shine sau 1-3 / rana. Yana yiwuwa a yi amfani da 850 MG 1-2 sau / rana. Idan ya cancanta, a hankali ana ƙaruwa da kashi tare da tazara tsakanin mako 1. har zuwa 2-3 g / rana.

Tare da maganin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa don yara masu shekaru 10 da haihuwa, mazan, kashi na farko shine 500 MG ko 850 1 lokaci / rana ko 500 MG sau 2 / rana. Idan ya cancanta, tare da tazara aƙalla 1 mako, za a iya ƙara yawan zuwa zuwa 2 g / rana a cikin kashi 2-3.

Bayan kwanaki 10-15, dole ne a daidaita adadin gwargwadon sakamakon ƙaddarawar glucose a cikin jini.

A haɗuwa da jiyya tare da insulin, kashi na farko na metformin shine 500-850 MG sau 2-3 / rana. An zaɓi kashi na insulin dangane da sakamakon ƙudurin glucose a cikin jini.

Side sakamako

Daga tsarin narkewa: mai yiwuwa (galibi a farkon jiyya) tashin zuciya, amai, zawo, flatulence, jin rashin jin daɗi a cikin ciki, a cikin sassan da aka keɓe - cin zarafin aikin hanta, hepatitis (ɓace bayan an dakatar da jiyya).

Daga gefen metabolism: da wuya - lactic acidosis (dakatar da magani ana buƙatar).

Daga tsarin hemopoietic: da wuya - a take hakkin shan sinadarin bitamin B 12.

Bayanin raunin da ya faru a cikin yara masu shekaru 10 da haihuwa sun yi daidai da na manya.

Tsarin saki, abun da aka shirya da marufi

An samar dashi a cikin nau'ikan allunan da aka sanya fim a cikin sashi na metformin: 500 MG, 850 MG, 1000 MG.

An kuma hada da:

hypromellose 2208,
sodium kararayi fumarate,
povidone K90,
don murfin: hypromellose 2910,
titanium dioxide
polysorbate 80
polyethylene glycol 6000.

An cusa shi ko dai a cikin blister of 10 guda, a cikin kwali na kwali daga 1 zuwa 10 blisters, ko a cikin kwantena na gilashin 15, 30, 60, 100 ko 120 Allunan.

Umarnin don amfani (hanya da sashi)

Ana ɗaukar Merifatin a baki tare ko bayan abinci. An zaɓi kashi ɗaya akayi daban-daban dangane da shaidar da ainihin bukatun jikin.

Jiyya yana farawa da mafi ƙarancin 500 mg sau 1-3 a rana. Idan ya cancanta, za a iya ƙara hankali - sau ɗaya a kowane mako 1-2, don kauce wa mummunan tasirin daga hanji. Matsakaicin adadin shine 2-3 g kowace rana.

Ga yara, farkon farashi shine 500 MG 1-2 sau a rana. Matsakaicin adadin shine 2 g kowace rana a cikin allurai masu yawa.

A lokacin jiyya tare da insulin, sashi na metformin yakamata ya zama 500-850 MG sau 2-3 a rana, kuma an zaɓi adadin hodar da ake buƙata gwargwadon bayanan bincike.

Sakamakon sakamako na miyagun ƙwayoyi:

lactic acidosis,
halayen rashin lafiyan halayen
tashin zuciya, amai,
matsalolin narkewa
ƙarfe ɗanɗano a bakin
malabsorption na bitamin B12,
anemia
tare da haɗakar magani - hypoglycemia.

Yawan abin sama da ya kamata

Wataƙila ci gaban lactic acidosis wanda ya haifar da tarin metformin a cikin jiki. Alamun ta sune tashin zuciya, amai, gudawa, zawo, ciki da ƙonewa, gazawar numfashi, ƙarancin zafin jiki, yanayin sanƙuwar jiki har zuwa rashin lafiya. Idan irin waɗannan bayyanar cututtuka suka bayyana, yakamata a dakatar da shan magunguna, a asibiti asibiti da mara lafiya kuma kuyi maganin hemodialysis da magani na alama. Wannan yanayin rayuwa ne na haɗari, musamman ga tsofaffi da yara, don haka yana da mahimmanci a san alamunsa.

Tare da yin amfani da concomitant tare da wasu kwayoyi don rage sukari jini, hypoglycemia na iya faruwa. Alamar ta: rauni, pallor, tashin zuciya, amai, rashin hankali (kafin faduwa cikin rashin lafiya), yunwar, da ƙari. Tare da tsari mai sauƙi, mutum zai iya daidaita yanayinsa ta hanyar cin abinci mai wadataccen carbohydrates. A cikin matsakaici mai tsauri da ƙarfi, ana buƙatar allurar glucagon ko kuma maganin rage ƙarfin wuta. Sannan mutum yana bukatar a kawo shi cikin nutsuwa sannan a ciyar dashi da abinci mai-carbohydrate. Yana da matukar muhimmanci ka nemi shawarar kwararru don gyara tafarkin magani.

Hulɗa da ƙwayoyi

Ana inganta tasirin magani tare da merifatin ta:

sauran jami'ai masu zubar da jini
beta hanawa,
NSAIDs
danazol
chlorpromazine
Amintattun kalmomin,
Kayakin
MAO da ACE inhibitors,
karafarini,
ethanol.

Sakamakon metformin ya raunana ta:

glucagon,
epinephrine
thiazide da dip,
glucocorticosteroids,
cututtukan mahaifa
tausayawa
maganin hana haihuwa
sabbin kayan tarihin,
nicotinic acid.

Cimetidine yana rage jinkirin kawar da metformin daga jiki kuma yana iya haifar da lactic acidosis.

Merifatin da kanta tana inganta tasirin abubuwan coumarin.

Lokacin da yake ba da bayanin magani tare da wannan wakili, likitan halartar ya kamata ya zama mai lura da yawan abubuwan da ke sama.

Umarni na musamman

Yayin gudanar da aikin jiyya, yana da muhimmanci a kula da yanayin kodan. Game da duk wani tuhuma da keta hurumin aikinsu, to, karɓar wannan kayan aiki da aka soke.

Metformin kanta ba ya shafar ikon fitar da abin hawa, duk da haka, a hade tare da insulin ko sulfonylurea, akwai irin wannan tasirin. Sabili da haka, tare da maganin haɗin gwiwa, yakamata ku ƙi fitar da mota kuma kuyi aiki tare da ƙananan hanyoyin.

Barasa na iya haifar da lactic acidosis, saboda haka shan shi ba a so.

A cikin ayyukan tiyata mai zuwa, yayin kulawa da cututtukan cututtuka, raunin raunin da ya faru, fashewar cututtukan cututtukan ƙwayar cuta, ba a amfani da maganin.

Ya kamata mai haƙuri ya san alamun cututtukan sakamako, cututtukan hypoglycemia da lactic acidosis kuma zai iya ba da taimako na farko.

Kwayoyin ba su ƙunshi carcinogens.

Mahimmanci! Ana bayar da magani ne kawai kawai takardar sayen magani!

Yarda da tsufa

Ana amfani da allunan da ke tattare da Metformin a cikin kula da tsofaffi, amma tare da taka tsantsan, tun da suna da haɗarin haɓakawa na haɓaka cututtukan jini da na lactic acidosis, musamman lokacin da suke yin aiki ta jiki. Wannan rukunin shekarun yana buƙatar kulawa ta kusa ta ƙwararrun masani da kuma kula da yanayin ƙodan.

Sharuɗɗan da yanayin ajiya

Ya kamata a kiyaye maganin a cikin duhu, wuri mai bushewa ga yara a yawan zafin jiki. Zamanin amfani shine shekaru 2 daga ranar fitowa. Sannan sai a zubar da allunan.

Wannan kayan aikin yana da analogues da yawa. Yana da amfani ku fahimci kanku tare dasu don kwatanta kaddarorin da tasiri.

Bagomet. Wannan maganin yana haɗuwa ne, ya haɗa da abubuwa masu aiki da metformin da glibenclamide. Kamfanin Chemist Montpellier, Argentina ne ya kirkira. Kudinsa daga 160 rubles a kowane kunshin. Tasirin maganin yana tsawan lokaci. Tashin bagomet ya dace da amfani kuma ana samunsa a kantin sayar da magani. Yana da daidaitattun contraindications.

Gliformin. Wannan maganin, wanda ya hada da metformin, shine kamfanin kamfanin na gida na Akrikhin ya kera shi. Farashin kayan kwalliya ya kasance daga 130 rubles (Allunan 60). Wannan kyakkyawan misali ne na magungunan kasashen waje, amma iyakantacce ne a amfani. Don haka, ba za a iya amfani da glyformin don kula da lafiyar mata masu juna biyu, yara da tsofaffi ba. Koyaya, an lura da kyakkyawan sakamako a cikin lura da ciwon sukari a baki ɗaya.

Metformin. Magunguna tare da kayan aiki guda ɗaya a cikin gindi. Akwai masana'antun da yawa: Gideon Richter, Hungary, Teva, Isra'ila, Canonpharma da Ozone, Russia. Kudin don shirya magungunan zai zama rubles 120 da ƙari. Wannan analog ne mai araha mafi tsada na Merifatin, kayan aiki mai araha kuma mai inganci.

Glucophage. Waɗannan allunan suna ɗauke da metformin a cikin abun da ke ciki. Manufacturer - Kamfanin Merck Sante a Faransa. Farashin magani shine 130 rubles da ƙari. Wannan ana misali ne na ƙasashen waje na Merifatin, akwai don siye da kan ragi. Tana da tasiri na ɗan gajeren lokaci da na dogon lokaci. Contraindications ne saba: magani bai kamata a bai wa yara, mata masu juna biyu da tsofaffi. Nazarin game da miyagun ƙwayoyi suna da kyau.

Siofor. Wadannan allunan kuma suna kan metformin. Mai kera - kamfanonin Jamus na Jamus Chemie da Menarini. Kudin shirya kaya zai zama rubles 200. Akwai akan abubuwan zaɓi da kan tsari. Ayyukanta ya zama matsakaici a cikin lokaci, za'a iya amfani dashi a hade tare da wasu kwayoyi. Jerin contraindications daidaitacce.

Metfogamma. Abunda yake aiki daidai yake da cikin merifatin. Masana'antar Werwag Pharm, ta Jamus. Akwai Allunan daga 200 rubles. Wannan aikin ya yi kama, kamar dai yadda aka hana aikace-aikacen. Kyakkyawan zaɓi na ƙasashen waje mai kyau da araha.

Hankali! Sauye sauye daga wani zuwa wani magani na hypoglycemic ana aiwatar da shi a karkashin kulawar likita. An haramta shan magani!

Yawancin bita da kullun na merifatin suna da kyau. Ingantaccen tasiri, an lura da ikon ɗauka tare da wasu magunguna. Amma game da sakamako masu illa, marasa lafiya suna rubuta cewa suna kawai a farkon farawa, yayin da jiki ke saba da miyagun ƙwayoyi. Ga waɗansu, magani bai dace ba.

Olga: “Na kamu da cutar sankarau. Na dade ina jinyarsa, galibi tare da kwayoyi tare da metformin a cikin abun da ke ciki. Kwanan nan na gwada wa Merifatin kan shawarar likita na. Ina son sakamakonsa na dindindin. Ingancin ba mai gamsarwa ba ne. Kuma a cikin kantin magani koyaushe yake. Don haka kayan aiki ne mai kyau. ”

Valery: “Na kamu da ciwon sukari da yawa. Duk abin da na gwada, riga abincin bai taimaka. Likita ya ba da Merifatin, ya lura cewa ya kamata ya taimaka rage nauyi. Kuma ya yi gaskiya. Bawai kawai na sa sukari na yanzu ba, amma na riga na rasa kilo uku a kowane wata. A gare ni, wannan ci gaba ne. Don haka ina ba da shawarar shi. ”

Form sashi

Allunan biconvex Allunan, fim mai rufe farin tare da hadari a gefe guda. A bangaran giciye, babban yana da fari ko fari fari.

Kwamfutar hannu 1 ya ƙunshi:

Abunda yake aiki: metformin hydrochloride 1000 mg.

Mahalarta: hypromellose 2208 10.0 mg, povidone K90 (collidone 90F) 40.0 mg, sodium stearyl fumarate 10.0 mg.

Fim-mai narkewa mai ruwa: hypromellose 2910 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 1.8 mg, polysorbate 80 (tween 80) 0.2 mg, titanium dioxide 4.0 mg.

Pharmacodynamics

Side effects

Ana kiyasta yawan tasirin magungunan kamar haka: sau da yawa (≥1 / 10), sau da yawa (≥1 / 100, 35 kg / m2,

- tarihin ciwon suga

- tarihin iyali na ciwon sukari a cikin dangi na digiri na farko,

- increasedarin maida hankali ga triglycerides,

- rage yawan taro na HDL cholesterol,

Tasiri kan iya tuka motocin da kera:

Monotherapy tare da metformin ba ya haifar da hypoglycemia sabili da haka ba ya tasiri da ikon fitar da motoci da injuna. Kodayake, ya kamata a yi gargaɗi ga marasa lafiya game da haɗarin hypoglycemia lokacin amfani da metformin a hade tare da sauran magungunan hypoglycemic (abubuwan da suka samo asali na sulfonylurea, insulin, repaglinide, da sauransu).

Nau'in nau'in ciwon sukari na 2, musamman a cikin marasa lafiya tare da kiba, tare da rashin tasirin maganin abinci da aikin motsa jiki:

- a cikin manya, kamar yadda monotherapy ko a hade tare da sauran wakilai na baka hypoglycemic ko tare da insulin,

- a cikin yara daga shekara 10 a matsayin monotherapy ko a hade tare da insulin. Yin rigakafin kamuwa da ciwon sukari na 2 a cikin marasa lafiya da masu ciwon sukari tare da ƙarin abubuwan haɗari don haɓaka ciwon sukari na type 2, wanda canje-canjen rayuwar ba su ba da izinin isasshen ikon sarrafa haɓaka ba.

Magunguna na Merifatin: umarnin don amfani

Don daidaita matakan glucose a cikin jini, ana amfani da magunguna daban-daban, waɗanda suka haɗa da Merifatin. Magungunan ƙwaƙwalwar ƙwayar cuta yana da contraindications da sakamako masu illa, don haka kafin fara magani, kuna buƙatar ziyarci ƙwararrun masanin kimiyya kuyi nazarin umarnin.

Saki siffofin da abun da ke ciki

Ana samun magungunan a cikin nau'ikan allunan 500 MG, 850 MG da 1000 MG, mai rufi. An sanya su cikin guda 10. cikin nutsuwa. Kunshin kwali na iya ƙunsar 1, 2, 3, 4, 5, 6, 8, 9, ko blister 10. Allunan za'a iya sanya su a cikin gilashi na polymer na guda 15., Inji mai kwakwalwa 30, inji mai kwakwalwa 60., 100 inji mai kwakwalwa. ko kwayoyi 120. Abunda yake aiki shine metformin hydrochloride. Abubuwa masu taimako sune povidone, hypromellose da sodium stearyl fumarate. Fim ɗin mai narkewa mai ruwa-ruwa ya ƙunshi polyethylene glycol, titanium dioxide, hypromellose da polysorbate 80.

Tare da kulawa

Suna ɗaukar magunguna a hankali yayin gudanar da aikin tiyata da raunin da ya faru lokacin da ya zama dole a ɗauki insulin, ciki, giya mai ƙoshin ƙarfi ko kuma giya mai ƙoshin ƙarfi, yin biyayya ga ƙarancin kuzari, lactic acidosis, da kuma kafin ko bayan rediyototope ko gwajin x-ray, a yayin da ake sarrafa waken aidin-mai dauke da bambancin wakili ga mai haƙuri .

Yayin cikin ciki, ya kamata a dauki Merifatin tare da kulawa sosai.

Yadda ake ɗaukar Merifatin?

An yi nufin samfurin don amfani da baka. Sigar farko a lokacin monotherapy a cikin marasa lafiya shine 500 mg 1-3 sau a rana. Za'a iya canza kashi zuwa 850 mg 1-2 sau a rana. Idan ya cancanta, ana ƙara yawan zuwa 3000 MG na kwana 7.

Yara an haife shekaru 10 ana basu damar shan 500 MG ko 850 MG sau daya a rana ko 500 MG 2 sau a rana. Za'a iya ƙara yawan sashi a cikin mako guda zuwa 2 g kowace rana don allurai 2-3. Bayan kwanaki 14, likita ya daidaita yawan magunguna, la'akari da matakin sukari a cikin jini.

Lokacin da aka haɗaka tare da insulin, kashi na Merifatin shine 500-850 MG sau 2-3 a rana.

Gastrointestinal fili

Daga bangaren narkewa, ana tashin ciki, amai, gudawa, ciwon ciki da rashin ci. Alamar mara kyau tana faruwa a matakin farko na magani kuma tafi gaba. Domin kada ya yi karo da su, ya zama dole a fara da ƙaramar ƙwaƙwalwa kuma sannu a hankali ƙara shi.

Yin hulɗa tare da wasu kwayoyi

An hana shi haɗuwa da metformin tare da magungunan radiopaque-iodine. Tare da taka tsantsan, suna ɗaukar Merifatin tare da Danazol, Chlorpromazine, glucocorticosteroids, diuretics, injection beta2-adrenergic agonists da jami'ai na antihypertensive, banda masu hana masu agiotensin canza enzyme.

An lura da karuwa a cikin taro na metformin a cikin jini a lokacin hulɗa tare da magungunan cationic, daga cikinsu amiloride. Absorarin ƙwayar metformin yana faruwa lokacin da aka haɗu da nifedipine. Maganin hana haihuwa na ciki yana rage tasirin maganin cutar.