Kefsepim - umarnin don amfani

Alamu don amfani da miyagun ƙwayoyi Kefsepim su ne:
- ciwon huhu (matsakaici da mai tsanani) wanda ya haifar da ƙwaƙwalwar ƙwayar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa (ciki har da shari'ar haɗin gwiwa tare da bacteremia concomitant), Pseudomonas aeruginosa, Klebsiella pneumoniae ko Enterobacter spp.
- urinary fili cututtuka (duka biyu masu rikitarwa kuma ba tare da rikitarwa ba),
- Cutar cututtukan fata da fata,
- rikituttukan cikin ciki mai rikitarwa (hade da metronidazole) wanda ya haifar da Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.,
- tafiyar matakai masu rarrabuwar cuta waɗanda suka haɗu da asalin yanayin rashin rigakafi (alal misali, febrile neutropenia),
- rigakafin kamuwa da cuta yayin tiyata,

Side effects

Daga tsarin narkewa: zawo, amai, amai, maƙarƙashiya, ciwon ciki, dyspepsia,
Tsarin zuciya: jin zafi a bayan sternum, tachycardia,
Allergic halayen: itching, fata fatar, anaphylaxis, zazzabi,
Tsarin juyayi na tsakiya: ciwon kai, fainting, rashin bacci, paresthesia, damuwa, rikicewa, damuwa,
Tsarin numfashi: tari, makogwaro, gajeruwar numfashi,
Abubuwan da suka shafi gida: tare da gudanarwa na ciki - phlebitis, tare da gudanarwar intramuscular - hyperemia da jin zafi a wurin allurar,
Sauran: asthenia, sweating, vaginitis, na gefe na ciki, ciwon baya, leukopenia, neutropenia, karuwa a cikin prothrombin,

Ciki

Amfani da magani Kefsepim lokacin daukar ciki ne kawai zai yuwu a wasu lokuta inda amfanin da aka yiwa mahaifiyar yafi karfin hadarin da tayi.
Idan ya cancanta, yin amfani da miyagun ƙwayoyi yayin shayarwa ya kamata ya yanke shawara akan dakatar da shayarwa.

Yin hulɗa tare da wasu kwayoyi

Yin amfani da babban allurai na aminoglycosides lokaci guda tare da miyagun ƙwayoyi KefsepimYa kamata a kula don lura da aikin renal saboda yuwuwar nephrotoxicity da ototoxicity na maganin rigakafin aminoglycoside. An lura da cewa an yi amfani da Nephrotoxicity bayan yin amfani da sauran ƙwayoyin cuta na lokaci guda tare da cututtukan diuretics, kamar furosemide. Magungunan rigakafin cututtukan ƙwayar cuta marasa lalacewa, rage jinkirin kawar da cephalosporins, suna kara haɗarin zubar jini. Taro na Kefsepim daga 1 zuwa 40 mg / ml. ya dace da irin waɗannan hanyoyin maganin: 0.9% maganin sodium chloride don allura, 5% da 10% maganin glucose don allurar, 6M sodium bayani na allura, glucose 5% da 0.9% maganin sodium chloride don allurar, Ringer's solution with lactate da 5% dextrose bayani don allura. Don guje wa hulɗa da miyagun ƙwayoyi tare da wasu kwayoyi, mafita na Kefsepim (kamar yawancin maganin rigakafin beta-lactam) bai kamata a gudanar da su ba lokaci guda tare da hanyoyin maganin metronidazole, vancomycin, Gentamicin, tobramycin sulfate da netilmicin sulfate. Game da alƙawarin da Kefsepim na miyagun ƙwayoyi tare da waɗannan kwayoyi, dole ne ku shigar da kowane ƙwayoyin rigakafi daban.

Tsari sashi:

foda don bayani don gudanarwar ciki da jijiyar ciki

a cikin kwalba daya ya ƙunshi:

Take

Abun ciki, g

0,5 g

1 g

Cefepime hydrochloride monohydrate, ana lissafta shi tare da cefepime

(har zuwa pH daga 4.0 zuwa 6.0)

foda daga fari zuwa fari fari.

Aikin magunguna

Pharmacodynamics

Cefepime wani tsararren ƙwayar cuta cephalosporin ne. Cepepime yana hana kwayar kwayar halitta bango na kwayan cuta, yana da fadi-iri na kwayar cuta ta hana kwayar gram-tabbatacce da kuma gram-korau, gami da yawancin larura da ke jure aminoglycosides ko maganin rigakafin cephalosporin na uku kamar su ceftazidime.

Cepepime yana da tsayayya sosai ga hydrolysis na yawancin beta-lactamases, yana da ƙarancin dangantaka ga beta-lactamases kuma cikin sauri ya shiga cikin ƙwayoyin ƙwayoyin cuta na gram-korau.

An tabbatar da cewa lokacin farin ciki yana da kusancin gaske ga nau'in sinadarin penicillin mai dauke da sinadarai (PSB), alakar soyayya ga nau'ikan 2 PSB, da kuma alaƙar matsakaici don nau'in 1a da 16 PSB. Cepepime yana da tasirin ƙwayar cuta a cikin ɗimbin ƙwayoyin cuta.

Cepepime yana aiki da waɗannan ƙananan ƙwayoyin:

Staphylococcus aureus (gami da nau'in samarda beta-lactamase), epidmidis na staphylococcus (gami da nau'in beta-lactamase), sauran nau'in staphylococcus spp. C), hucin hucin ciki da ciki (tare da damuwa tare da matsakaiciyar juriya ga penicillin - ƙaramin inhibitory maida hankali ne daga 0.1 zuwa 1 μg / ml), sauran beta-hemolytic Streptococcus spp. (Cungiyoyi C, G, F), Streptococcus bovis (rukunin D), Streptococcus spp. rukunan budurwai,

Lura: Yawancin ƙwayoyin enterococcal, irin su Enterococcus faecalis, da methicillin-sta staloloccci suna tsayayya da yawancin maganin rigakafin cephalosporin, gami da cefepime.

Acinetobacter calcoaceticus (ƙananan nau'in anitratus, lwofii),
Aeromonas hydrophila,
Capnocytophaga spp.,
Citrobacter spp. (gami da Citrobacter diversus, Citrobacter freundii),
Campylobacter jejuni,
Enterobacter spp. (ciki har da Enterobacter cloacae, Enterobacter aerogenes, Enterobacter dagazakii),
Zakariya coli,
Gardnerella vaginalis,
Haemophilus ducreyi,
Haemophilus mura (ciki har da beta-lactamase na haifar da damuwa),
Haemophilus parainfluenzae, Hafnia alvei,
Klebsiella spp. (ciki har da Klebsiella ciwon huhu, Klebsiella oxytoca, Klebsiella ozaenae),
Legionella spp.,
Karin Morganella,
Moraxella catarrhalis (Branhamella catarrhalis) (gami da nau'in samarda beta-lactamase),
Neisseria gonorrhoeae (gami da nau'in samarda beta-lactamase),
Neisseria meningitidis,
Pantoea agglomerans (wanda a da ake kira Enterobacter agglomerans),
Kare spp. (gami da kariya daga Proteus mirabilis da Proteus vulgaris),
Bayanai spp. (gami da samar da kayan aikin bayarda, na ba da bada baya),
Pseudomonas spp. (gami da Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzer),
Salmonella spp.,
Serratia spp. (gami da maganin marrarancin Serratia, Serratia liquefaciens),
Shigella spp.,
Yersinia adama,

Lura: Cefepime ba shi da aiki a kan yawancin nau'in cutar Stenotrophomonas maltophilia, wanda aka sani da Xanthomonas maltophilia da Pseudomonas maltophilia).

Anaerobes:

Bacteroides spp.,
Clostridium turare
Fusobacterium spp.,
Mobiluncus spp.,
Marikina spp.,
Prevotella melaninogenica (wanda aka sani da Bacteroides melaninogenicus),
Veillonella spp.,

Lura: Cepepime baya aiki da Bacteroides fragilis da Clostridium difficile. Secondary juriya da microorganisms ga cefepime tasowa a hankali.

Pharmacokinetics

Matsakaicin yawan plasma na lokacin farin ciki a cikin manya masu lafiya a lokuta daban-daban bayan gudanarwa guda ɗaya na cikin ciki na mintuna 30 zuwa 12 sa'o'i da matsakaicin yawa (C_tah) ana ba su a cikin tebur da ke ƙasa.

Matsakaicin ƙwaƙwalwar ƙwaƙwalwar ƙwayar plasma (μg / ml) bayan gudanarwar cikin jijiya.