Nativa® (Nativa)

Sunan ciniki: Nativa
Sunan kasa da kasa mai zaman kansa: Harshen
Sunan sunadarai: 3-sulfanylpropanoyl-L-tyrosyl-L-phenylalanyl-L-lutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginylglycinamide cyclic 1-6 disulfide
Tsari sashi: kwayoyin hana daukar ciki

Abun ciki kowace kwamfutar hannu
Abu mai aiki 0.1 MG 0.2 MG
Desmopressin Acetate 0.1 mg 0.2 mg
cikin sharuddan desmopressin 0.089 mg 0.178 mg
Fitowa
Lactose Monohydrate 10 MG 10 MG
Crospovidone XL 5 MG 5 MG
Magnesium stearate 2 MG 2 MG
Ludipress har zuwa 200 MG zuwa 200 MG
cikin sharuddan aka gyara:
Lactose Monohydrate 170.1 mg 170.0 mg
Crospovidone 6.4 mg 6.4 mg
Povidone 6.4 MG 6.4 MG

Bayanin
Sashi 0.1 MG: farin fararen kwamfutar hannu zagaye tare da chamfer kuma hadarin a gefe ɗaya
Sashi 0.2 mg: farin fararen kwamfutar hannu zagaye tare da chamfer kuma hadarin a gefe ɗaya

Rukunin Magunguna: Ciwon sukari mellitus magani
Lambar ATX: H01VA02

Kayan magunguna

Pharmacodynamics
Desmopressin alamu ne na tsarin halitta na halitta arginine-vasopressin, tare da tasirin antidiuretic sakamako. An samo Desmopressin sakamakon canje-canje a cikin tsarin kwayoyin vasopressin - lalata lalata na L-cysteine ​​da maye gurbin 8-L-arginine don 8-D-arginine.
Desmopressin yana ƙaruwa da ƙarfin aiki na epithelium na distal rikitarwa tubules na nephron zuwa ruwa kuma yana ƙaruwa da sake farfadowa. Canje-canje canje-canje a haɗe tare da ingantaccen ƙarfin maganin antidiuretic yana haifar da ƙayyadadden sakamako na desmopressin akan santsi na tsokoki na jijiyoyin jini da gabobin ciki idan aka kwatanta da vasopressin, wanda ke haifar da rashin halayen sakamako mara kyau. Ba kamar vasopressin ba, yana yin tsayi kuma ba ya haifar da karuwa a cikin jini (BP).
Yin amfani da desmopressin don insipidus na ciwon sukari na asalin asalin yana haifar da raguwa a cikin yawan fitsari wanda aka cire kuma a lokaci guda karuwar osmolarity na fitsari da raguwa a cikin ƙwayar jini na osmolarity na jini. Wannan yana haifar da rage yawan urination da raguwa a cikin ƙwayar nocturnal polyuria.
Matsakaicin tasirin maganin rigakafi lokacin da aka sha bakin ta yana faruwa a cikin awanni 4 zuwa 7. Tasirin maganin antidiuretic lokacin da aka sha bakinta a cikin kashi 0.1 - 0.2 MG - har zuwa awa 8, a kashi 0.4 MG - har zuwa awa 12.
Pharmacokinetics
Damuwa
Lokacin gudanarwa, an cimma matsakaicin ƙwayar plasma (Cmax) a cikin awa 0.9. Cin abinci na lokaci guda na iya rage matsayin sha daga hancin ciki (GIT) da kashi 40%.
Rarraba
Ofarar rarraba (Vd) shine 0.2 - 0.3 l / kg. Baƙon abu da shigowa - 5%. Desmopressin baya ƙetare shingen jini-kwakwalwa.
Kiwo
Kodan ya fice. Rabin-rayuwar (T1 / 2) idan aka sha bakinsa shi ne awa 1,5 zuwa 2.5.

Alamu don amfani

• ciwon sukari insipidus na asalin asalin
• Primary nocturnal enuresis a cikin yara sun girmi 5 years
• Nocturnal polyuria a cikin tsofaffi (azaman maganin rashin lafiya).

Contraindications don amfani
Idan kuna da ɗayan waɗannan cututtukan, tabbatar da tuntuɓi likitanku kafin shan maganin.
• Hypersensitivity to desmopressin ko wasu abubuwan maganin
• Halin ƙwaƙwalwar ƙwayar cuta ko ta psychogenic polydipsia
• Rashin bugun zuciya da sauran halaye na buƙatar gudanarwar cututtukan cututtukan fata
• Hyponatremia, gami da tarihi na (maida hankali ne ion sodium ion a cikin jini jini a ƙasa 135 mmol / l)
• Matsakaicin matsakaici da mummunan gazawar renal (ɗaukar hoto a kasa da 50 ml / min)
Yara kanana 'yan kasa da shekaru 4 (don maganin ciwon insipidus) da kuma shekaru 5 (don lura da cutar rashin wayewar kai na yara)
• Cutar rashin isasshen samar da maganin antidiuretic
Def Rashin Lactase, rashin haƙuri a cikin lactose, glucose-galactose malabsorption.

Tare da kulawa

yi amfani da miyagun ƙwayoyi don gazawar renal, fibrosis mafitsara, don keta ƙimar ma'aunin ruwa-electrolyte, haɗarin haɗarin karuwar matsin lamba intracranial, yayin daukar ciki.
Tare da matsanancin hankali yi amfani da magani a cikin tsofaffi marasa lafiya (fiye da 65 shekara) saboda babban haɗarin sakamako masu illa (riƙewar ruwa, hyponatremia). Lokacin da ake rubuta magani tare da Nativa, kwanaki 3 bayan fara gudanarwa kuma tare da kowane karuwa a cikin kashi, ya kamata a ƙaddara yawan haɗuwar sodium a cikin jini jini da kuma kula da yanayin haƙuri.

Yi amfani da lokacin daukar ciki da lokacin shayarwa

A cewar bayanan da aka sani, lokacin amfani da desmopressin a cikin mata masu juna biyu da masu ciwon insipidus, babu wasu sakamako masu illa ga lokacin daukar ciki, kan halin lafiyar mace mai ciki, tayin, da jariri.
Koyaya, amfanin da aka yiwa mahaifiyar da kuma yiwuwar haɗarin tayin ya kamata a daidaita.
Bincike ya nuna cewa yawan desmopressin da ke shiga jikin jariri wanda ke shan madara ta mace mai shan allurai na desmopressin ba shi da yawa wanda zai iya shafar diureis.

Jadawalin sashi, hanyar aikace-aikace, tsawon lokacin magani

A ciki. An zaɓi mafi kyawun ƙwayar magunguna daban-daban.
Ya kamata a sha magungunan a wani lokaci bayan cin abinci, tunda cin abinci na iya shafar shaye shayen da kuma ingancinsa.
Cutar sankara ta tsakiya Shawarar farawa don yara masu shekaru sama da 4 da haihuwa shine 0.1 mg 1-3 sau a rana. Bayan haka, an zaɓi sashi gwargwadon amsawar magani. Yawanci, kashi na yau da kullun yana daga 0.2 zuwa 1.2 MG. Ga mafi yawan marasa lafiya, mafi kyawun tsarin kulawa shine 0.1 - 0.2 mg 1-3 sau a rana.
Primary nocturnal enuresis: Shawarar farawa don yara masu shekaru 5 da manya sune 0.2 mg da dare. Idan babu sakamako, ana iya ƙara kashi zuwa 0.4 MG. Hanyar da aka bayar da shawarar cigaba da magani shine watanni 3. Ya kamata a yanke shawarar ci gaba da magani a kan bayanan asibiti wanda za a lura bayan dakatar da miyagun ƙwayoyi a cikin mako 1. Wajibi ne a lura da yarda da ƙuntata abubuwan shigar ruwa da yamma.
Polyuria na manya: Da shawarar fara farawa shine 0.1 mg da dare. Idan babu wani tasiri a cikin kwanaki 7, an kara kashi zuwa 0.2 MG sannan daga baya zuwa 0.4 MG tare da karuwa a kashi tare da adadin da bai wuce 1 lokaci a mako ba. Ka kiyaye haɗarin riƙe ruwa a cikin jiki. Idan bayan makonni 4 na magani da daidaituwa na sashi ba a lura da isasshen sakamako na asibiti, ci gaba da amfani da maganin ba da shawarar ba.

Hotunan 3D

Sashi da gudanarwa

A ciki. An zaɓi mafi kyawun ƙwayar magunguna daban-daban.

Ya kamata a sha magungunan a wani lokaci bayan cin abinci, tunda cin abinci na iya shafar shaye shayen da kuma ingancinsa.

Cutar sankara ta tsakiya Shawarar farawa don yara masu shekaru sama da 4 da haihuwa shine 0.1 mg 1-3 sau a rana. Bayan haka, an zaɓi sashi gwargwadon amsawar magani. Yawanci, kashi na yau da kullun yana daga 0.2 zuwa 1.2 MG. Ga mafi yawan marasa lafiya, mafi kyawun tsarin kulawa shine 0.1-0.2 mg sau 1-3 a rana.

Primary nocturnal enuresis: Shawarar farawa don yara masu shekaru 5 da manya sune 0.2 mg da dare. Idan babu sakamako, ana iya ƙara kashi zuwa 0.4 MG. Hanyar da aka bayar da shawarar cigaba da magani shine watanni 3. Ya kamata a yanke shawarar ci gaba da magani a kan bayanan asibiti wanda za a lura bayan dakatar da miyagun ƙwayoyi na mako 1. Kulawa da takaita abubuwan hana ruwa ruwa da yamma ya zama dole.

Nocturnal polyuria a cikin manya: Maganin farawa shine 0.1 mg da dare. Idan babu wani tasiri a cikin kwanaki 7, an kara kashi zuwa 0.2 MG sannan daga baya zuwa 0.4 MG (Yawan karuwar kashi ba ya wuce 1 lokaci na mako daya). Ka kiyaye haɗarin riƙe ruwa a cikin jiki. Idan bayan makonni 4 na magani da daidaituwa na sashi ba a lura da isasshen sakamako na asibiti, ci gaba da amfani da maganin ba da shawarar ba.

Mai masana'anta

Nativa LLC, Rasha.

Adireshin doka: 143402, Rasha, Yankin Moscow, gundumar Krasnogorsk, Krasnogorsk, st. 13 ga Oktoba.

Waya: 8 (495) 502-16-43, 8 (495) 644-00-59.

e-mail: [email protected], www.nativa.pro

Adireshin wuraren samarwa: 143422, Yankin Moscow, gundumar Krasnogorsk, s. Petrovo-Dalnee, Tarayyar Rasha, 142279, Yankin Moscow, gundumar Serpukhov, Obolensk, gini 7-8 ko 143952, Yankin Moscow, Balashikha, microdistrict. Dzerzhinsky, 40.

Contraindications

- Hypersensitivity to desmopressin ko wasu abubuwan maganin,

- al'ada ko polydipsia na psychogenic,

- rashin lafiyar zuciya da sauran halaye na bukatar gudanarwar cututtukan zuciya,

- hyponatremia, gami da tarihi na (maida hankali ne ion sodium ion a cikin jini na jini a ƙasa 135 mmol / l),

- matsakaici zuwa ga rashin cin nasara na koda

- shekarun yara har zuwa shekaru 4 (don maganin cutar insipidus na sukari) da kuma shekaru 5 (don lura da cutar rashin wayewar haihuwa na farko),

- ciwo na rashin isasshen ƙwayar antidiuretic,

- Rage karancin Lactase, rashin haƙuri a cikin lactose, glucose-galactose malabsorption.

Ana amfani da 'yan ƙasa tare da taka tsantsan idan har ta gazawar koda, ƙwayar mafitsara, rashin daidaituwa na ruwa, da yiwuwar haɗarin hauhawar cikin mahaifa yayin daukar ciki.

Dole ne a lura da hankali musamman lokacin amfani da miyagun ƙwayoyi a cikin tsofaffi marasa lafiya (fiye da shekaru 65) saboda babban haɗarin sakamako masu illa (riƙewar ruwa, hyponatremia). Lokacin da ake rubuta magani tare da Nativa, kwanaki 3 bayan fara gudanarwa kuma tare da kowane karuwa a cikin kashi, ya kamata a ƙaddara yawan haɗuwar sodium a cikin jini jini da kuma kula da yanayin haƙuri.

Formaddamar da tsari da abun da ke ciki

Tsarin sashi na Nativa shine Allunan 0.1 / 0.2 mg: zagaye, lebur, fari, tare da chamfer da haɗari a gefe guda (guda 30 a cikin kwalayen filastik, kwalban 1 a cikin kwali na kwali).

Abun ciki 1 kwamfutar hannu 0.1 / 0.2 mg:

• abu mai aiki: desmopressin acetate - 0.1 / 0.2 mg, cikin sharuddan desmopressin - 0.089 / 0.178 mg,
• abubuwa masu taimako: lactose monohydrate, crospovidone XL, magnesium stearate, ludipress (lactose monohydrate, crospovidone, povidone).

Yadda ake amfani: sashi da hanya na jiyya

A ciki, an zaɓi kashi na miyagun ƙwayoyi daban-daban.

Ya kamata a sha magungunan a wani lokaci bayan cin abinci, tunda cin abinci na iya shafar shaye shayen da kuma ingancinsa.

Tsarin cutar sankara ta tsakiya: shawarar da aka fara farawa ga yara sama da shekaru 4 da manya sune 0.1 mg 1-3 sau a rana. Bayan haka, an zaɓi sashi gwargwadon amsawar magani. Yawanci, kashi na yau da kullun yana daga 0.2 zuwa 1.2 MG. Ga mafi yawan marasa lafiya, mafi kyawun tsarin kulawa shine 0.1-0.2 mg sau 1-3 a rana.

Primary nocturnal enuresis: shawarar da aka fara farawa ga yara sama da 5 shekaru da manya shine 0.2 mg da dare. Idan babu sakamako, ana iya ƙara kashi zuwa 0.4 MG. Hanyar da aka bayar da shawarar cigaba da magani shine watanni 3. Ya kamata a yanke shawarar ci gaba da magani bisa ga bayanan asibiti wanda za'a lura dashi bayan dakatar da maganin a cikin mako 1. Wajibi ne a lura da yarda da ƙuntata abubuwan shigar ruwa da yamma.

Polyuria na manya: Da shawarar fara farawa shine 0.1 mg da dare. Idan babu wani tasiri a cikin kwanaki 7, an kara kashi zuwa 0.2 MG sannan daga baya zuwa 0.4 MG tare da karuwa a kashi tare da adadin da bai wuce 1 lokaci a mako ba. Ka kiyaye haɗarin riƙe ruwa a cikin jiki.

Idan bayan makonni 4 na magani da daidaituwa na sashi ba a lura da isasshen sakamako na asibiti, ci gaba da amfani da maganin ba da shawarar ba.

Pharmacodynamics

Desmopressin kwatankwacin tsari ne na hormone arginine-vasopressin kuma yana da tasirin maganin antidiuretic. An samo shi yayin aiwatar da canje-canje a cikin tsarin kwayoyin vasopressin.

Aikin Nativa ya kasance saboda ikonsa na haɓaka daɗaɗɗen ƙwayar epithelium na sassan abubuwa masu rikitarwa na tubules ɗin da ke rikitarwa zuwa ruwa, yana ƙara ƙaruwarsa. Babu sakamako masu illa guda biyu saboda ƙarancin sakamako na desmopressin akan ƙoshin lafiya na jijiyoyin jini da gabobin ciki idan aka kwatanta da vasopressin. Magungunan suna aiki na dogon lokaci kuma baya karuwar hawan jini.

Lokacin da aka magance desmopressin tare da insipidus na ciwon sukari na asalin asalin, ƙarar fitsari da aka cire tana raguwa, osmolarity din sa yana ƙaruwa, kuma ƙwayar cutar plasma na jini kuma yana raguwa, wanda ke haifar da raguwar yawan urination da raguwa a cikin polyuria na dare. Tasirin miyagun ƙwayoyi ya kai matsayinsa bayan sa'o'i 4-7 kuma ya kai tsawon sa'o'i 8-12, gwargwadon yawan da Nativa ya ɗauka.

Pharmacokinetics

Matsakaicin taro na desmopressin an kai shi ne bayan awanni 0.9. Cin abinci yana rage yawan shan abubuwa da kashi 40%. Ofarar da aka rarraba shine 0.2-0.3 l / kg. Kayan baya iya ƙaddamar da shinge na kwakwalwa-kwakwalwa. Cire rabin rayuwar yayi sa'o'i 1,5-2,5. Desmopressin da ƙodan ya keɓe shi.

Umarnin don yin amfani da Nativa: hanya da sashi

Ana ɗaukar allunan Nativa a baki kaɗan bayan cin abinci. An zaɓi kashi na miyagun ƙwayoyi a kowane yanayi daban-daban.

• insipidus na ciwon sukari na tsakiya: shawarar da aka fara bayarwa ita ce 0.1 mg, sau 1-3 a rana, sannan ana kara girman gwargwadon abin da ya shafi mai haƙuri,
• farko nocturnal enuresis: shawarar da aka fara bayarwa shine 0.2-0.4 mg a lokacin bacci. Tsawon lokacin magani ya kamata kimanin watanni 3. An yanke shawara game da cancantar ƙarin ilimin aikin ta hanyar tushen bayanan asibiti da aka samo a cikin kwanaki 7 bayan katse maganin. A lokacin kulawa, an ba da shawarar Nativa don bin tsarin dokar ƙarancin abinci da yamma,
• nocturnal polyuria a cikin manya: shawarar da aka fara bayarwa shine 0.1 mg a lokacin bacci. A cikin rashin sakamako bayan kwanakin 7 na shan miyagun ƙwayoyi, yana yiwuwa a kara kashi zuwa 0.2, kuma daga baya 0.4 mg / day, tare da tazara tsakanin mako guda. Idan babu sakamako na warkewa a cikin makonni 4 da shan Nativa, karin amfani da shi ba shi da amfani.

Side effects

• tsarin juyayi: ciwon kai, farin ciki, amai,
• tsarin narkewa: tashin zuciya, amai, bushe baki,
• tsarin zuciya da jijiyoyin jini: tachyarrhythmia na yau da kullun,
• kwayoyin hangen nesa: conjunctivitis,

Bugu da kari, abin da ya faru na farji na gefe, kazalika da karuwa a jiki.

Shan Nativa ba tare da hanawa a cikin shan ruwa ba na iya haifar da riƙewar ruwa a cikin jiki da hyponatremia.

Yawan abin sama da ya kamata

Doarfewar Nativa na iya haifar da riƙewar ruwa da hyponatremia tare da haɗuwa da ion sodium in cikin jini jini a ƙasa 135 mmol / L.

Shawarar da aka ba da shawara: dakatar da shan magani nan da nan, soke tsarin iyakanceccen shan ruwa, idan ya cancanta, samar da 0.9% ko maganin hypertonic sodium chloride. Game da bayyanar cututtuka na riƙewar ruwa mai ƙarfi (tsauraran rashi, asarar hankali), an wajabta furosemide.

Umarni na musamman

Wajibi ne a iyakance abincin da yake sha awa 1 kafin da kuma awanni 8 bayan shan Nativa, don guje wa faruwar abubuwan da ba a so.

Dangane da umarnin, Nativa yana cikin contraindicated a cikin marasa lafiya a cikin yanayin haifar da riƙe ruwa da rikicewar lantarki.

Don hana haɓakar hyponatremia, ana bada shawara don sarrafa yawan haɗuwar sodium a cikin jini.

A cikin marasa lafiyar da ke fama da rashin lafiyar urinary rashin daidaituwa, nocturia, dysuria, kamuwa da urinary tract, polydipsia, decompensated diabetes mellitus, sannan kuma idan ana zargin mafitsara ko kumburin mahaifa, yana da kyau a jiyya da kuma gano waɗannan cututtukan kafin ɗaukar Nativa.

An bada shawarar dakatar da shan Nativa idan akwai cututtukan cututtukan jiki, cututtukan zuciya da zazzabi.

Haihuwa da lactation

Babu wani bayani game da illar cutar desmopressin akan ciki, yanayin tayin, jariri, da mahaifiyarta, amma kafin amfani da Nativa, yakamata a auna girman fa'idar / hadarin.

Yawan maganin yana nunawa a cikin madarar uwa yayin shan Nativa a babban allurai ba shi da mahimmanci don yin tasiri akan dialsis na jariri.

Hulɗa da ƙwayoyi

• kwayoyi masu hauhawar jini: hadarin inganta tasirin su,
• buformin, tetracycline, norepinephrine, shirye-shiryen lithium: rage tasirin antidiuretic na desmopressin,
• magungunan rigakafin rashin kumburi (NSAIDs): haɗarin sakamako masu illa suna ƙaruwa;
• indomethacin: haɓaka tasirin desmopressin ba tare da ƙara yawan lokacin aikinsa ba,
• tricyclic antidepressants, mai zaɓar serotonin reuptake inhibitors, narcotic analgesics, carbamazepine, chlorpromazine, lamotrigine, NSAIDs: na iya inganta tasirin antidiuretic na Nativa, da haɓaka haɗarin riƙe ruwa da hyponatremia,
• loperamide kuma, mai yiwuwa, wasu magunguna waɗanda ke rage jigilar peristalsis: na iya haifar da ƙaruwa sau uku a cikin taro na desmopressin a cikin plasma, yana ƙara haɓakar haɗarin riƙewar ruwa da hyponatremia,
• dimethicone: ƙwayar desmopressin na iya raguwa.

Analogs na Nativa sune Vasomirin, Desmopressin, Minirin, Nourem, Presineks.

Farashin Nativa a cikin magunguna

Farashin da aka kiyasta na Nativa shine 1330 r don kunshin wanda ya ƙunshi allunan 30 na 0.1 MG.

Ilimi: Jami'ar Kiwon lafiya ta jihar Rostov, kwararrun "General Medicine".

Bayanai game da miyagun ƙwayoyi an samar da su, an bayar da su ne don dalilai na bayanai kuma baya maye gurbin umarnin hukuma. Kai magani yana da haɗari ga lafiya!

A cewar masana kimiyya da yawa, hadadden bitamin ba su da amfani ga mutane.

Tare da ziyarar yau da kullun a kan tanning, damar samun ciwon fata yana ƙaruwa da 60%.

A Burtaniya, akwai wata doka wacce a ciki wacce likitan tiyata zai iya yin aikin tiyata ga mara lafiyar idan ya sha sigari ko kuma ya wuce kiba. Yakamata mutum ya daina munanan halaye, sannan kuma, wataƙila, ba zai buƙaci sa hannun tiyata ba.

Kasusuwa na mutum sau huɗu sun fi ƙarfin ƙarfi.

Wani dan Australiya mai shekaru 74 James Harrison ya zama mai bayar da gudummawar jini kusan sau 1,000. Yana da nau'in jini wanda ba a taɓa gani ba, rigakafin cututtukan rigakafi waɗanda ke taimaka wa jarirai masu ƙarancin rashin wadatar rayuwa. Don haka, Ostiraliya ta sami kusan yara miliyan biyu.

Jinin ɗan adam "yana gudana" ta cikin jiragen ruwa a ƙarƙashin matsanancin matsin lamba, kuma idan an keta mutuncin sa, zai iya harba har zuwa mita 10.

Ya kasance hakan yana haɓaka jiki da oxygen. Koyaya, an rarraba wannan ra'ayin. Masana ilimin kimiyya sun tabbatar da cewa hayaniya, mutum yana sanya kwantar da hankali da haɓaka aikinsa.

Idan kayi murmushi sau biyu kawai a rana, zaku iya rage karfin jini da rage hadarin bugun zuciya da bugun jini.

Yayin sneeze, jikinmu gaba ɗaya yana dakatar da aiki. Har zuciyar ta tsaya.

A cewar binciken na WHO, tattaunawa ta rabin sa'a a kowace rana ta wayar hannu na kara yiwuwar cizon ciwan kwakwalwa da kashi 40%.

Yawan nauyin kwakwalwar mutum kusan kashi biyu cikin dari ne na nauyin jiki, amma yana cin kusan kashi 20% na iskar oxygen da ke shiga jini. Wannan hujja tana sanya kwakwalwar dan Adam matsanancin rauni don lalacewa ta hanyar karancin iskar oxygen.

Kodan mu na iya tsarkake lita uku na jini a cikin minti daya.

Cutar hanta ita ce mafi girman jikinmu. Matsakaicin nauyinta shine kilogiram 1.5.

Masana kimiyyar Amurka sun gudanar da gwaje-gwaje a kan mice kuma sun yanke hukuncin cewa ruwan kankana yana hana haɓakar atherosclerosis na hanyoyin jini. Groupaya daga cikin ƙungiyar mice sun sha ruwa a bayyane, ɗayan kuma ruwan 'ya'yan itace kankana. A sakamakon haka, tasoshin rukunin na biyu sun kasance ba su da matattarar cholesterol.

Miliyoyin ƙwayoyin cuta ana haihuwar su, suna rayuwa kuma suna mutuwa cikin gutuwarmu. Ana iya ganin su kawai da girman girma, amma idan sun taru, za su dace da kofin kofi na yau da kullun.

Yunkurin farko na fure yana zuwa ƙarshen ƙarshe, amma za a maye gurbin bishiyoyi masu banƙyama da ciyawa daga farkon Yuni, wanda zai rikitar da masu rashin lafiyar.

Aikin magunguna

Abubuwan da ke aiki na Nativa shine desmopressin, analog na tsari na yanayin halitta na arginine-vasopressin, tare da tasirin maganin antidiuretic. Desmopressin yana ƙaruwa da ƙarfin aiki na epithelium na distal rikitarwa tubules na nephron zuwa ruwa kuma yana ƙaruwa da sake farfadowa. Canje-canje canje-canje a haɗe tare da ingantaccen ƙarfin maganin antidiuretic yana haifar da ƙayyadadden sakamako na desmopressin akan santsi na tsokoki na jijiyoyin jini da gabobin ciki idan aka kwatanta da vasopressin, wanda ke haifar da rashin halayen sakamako mara kyau. Ba kamar vasopressin ba, yana yin tsayi kuma ba ya haifar da karuwa a cikin jini (BP).

Yin amfani da desmopressin don insipidus na ciwon sukari na asalin asalin yana haifar da raguwa a cikin yawan fitsari wanda aka cire kuma a lokaci guda karuwar osmolarity na fitsari da raguwa a cikin ƙwayar jini na osmolarity na jini. Wannan yana haifar da rage yawan urination da raguwa a cikin ƙwayar nocturnal polyuria.

Matsakaicin tasirin maganin antidiure lokacin da aka yi maganin ta baki yana faruwa a cikin awanni 4-7. Tasirin maganin antidiuretic lokacin da aka sha shi a baki a cikin kashi 0.1-0.2 mg yana zuwa awa 8, a kashi 0.4 mg - har zuwa awa 12.