Metformin 500 MG 60 Allunan: farashi da analogues, sake dubawa

Allunan, 500 MG, 850 MG da 1000 MG

Tabletaya daga cikin kwamfutar hannu 500 MG ya ƙunshi:

abu mai aiki: metformin hydrochloride - 500 MG.

amagabata: celclosese microcrystalline, sirinum croscarmellose, tsarkakakken ruwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Tabletaya daga cikin kwamfutar hannu na 850 mg ya ƙunshi:

abu mai aiki: metformin hydrochloride - 850 mg.

akarin taimako abubuwa: microcrystalline cellulose, sirinum croscarmellose, tsarkakakken ruwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Tabletaya daga cikin kwamfutar hannu na 1000 MG ya ƙunshi:

mai aiki abu: metformin hydrochloride - 1000 mg.

wadatarwawarkarwa abubuwa: microcrystalline cellulose, sirinum croscarmellose, tsarkakakken ruwa, povidone (polyvinylpyrrolidone), magnesium stearate.

Allunan 500 MG - allunan zagaye-silinlar kwalliya na farin ko kusan fararen launi tare da haɗari a gefe guda da kuma chamfer a garesu.

Allunan 850 mg, 1000 mg - oval biconvex allunan farin ko kusan farin launi tare da haɗari a gefe ɗaya.

Kayan magunguna

Pharmacokinetics

Bayan gudanar da baki, ana amfani da metformin daga cikin gastrointestinal fili sosai. Cikakken bioavailability shine 50-60%. Matsakaicin maida hankali (Cmax) (kamar 2 μg / ml ko 15 μmol) a cikin plasma an kai shi bayan awa 2.5.

Tare da shigowa na lokaci daya, shakar metformin zai ragu kuma yana jinkirta.

An rarraba Metformin cikin hanzari a cikin nama, kusan ba a ɗaura shi ga furotin plasma ba. Yana cikin metabolized sosai ga rauni sosai kuma kodan ya keɓe shi. Tabbatar da metformin a cikin batutuwa masu ƙoshin lafiya shine 400 ml / min (sau 4 fiye da yardawar creatinine), wanda ke nuna kasancewar ƙwayar canalic aiki. Rabin rayuwar shine kimanin awanni 6.5. Tare da gazawar koda, yana ƙaruwa, akwai haɗarin tarin ƙwayoyi.

Metformin yana rage hyperglycemia ba tare da haifar da ci gaban hypoglycemia ba. Sabanin abubuwan da aka samo na sulfonylurea, ba ya tayar da rufin insulin kuma ba shi da tasirin hypoglycemic a cikin mutane masu lafiya. Theara hankalin mai karɓar mahaifa zuwa insulin da kuma amfani da glucose ta sel. Yana hana gluconeogenesis a cikin hanta. Yana jinkirta ɗaukar carbohydrates a cikin hanjin. Metformin yana ƙarfafa haɗin glycogen ta hanyar aiki akan glycogen synthase. Capacityara ƙarfin jigilar kayayyaki na kowane nau'ikan jigilar jini na membrane.

Bugu da kari, yana da fa'ida mai tasiri akan metabolism na lipid: yana rage abun cikin jimlar cholesterol, karancin lipoproteins da triglycerides.

Yayin shan metformin, nauyin jikin mai haƙuri ko dai ya kasance tsayayye ko yana raguwa da matsakaici.

Alamu don amfani

Nau'in nau'in ciwon sukari na 2, musamman a cikin marasa lafiya tare da kiba, tare da rashin tasirin maganin abinci da aikin motsa jiki:

A cikin manya, kamar su maganin cututtukan dabbobi ko a hade tare da wasu wakilai na baka na jini, ko tare da insulin,

In a cikin yara daga shekaru 10 a matsayin maganin kashewa ko a haɗa tare da insulin.

Sashi da gudanarwa

Allunan ya kamata a ɗauka a baki, a haɗiye su gaba ɗaya, ba tare da taunawa ba, a lokacin ko nan da nan bayan abinci, shan ruwa mai yawa.

Manya: maganin monotherapy da magani a haɗe tare da sauran wakilai na baka mai magana da ƙwayar cuta:

• Yawan farawa shine 500 MG ko 850 mg sau 2-3 a rana bayan ko lokacin abinci. Furtherarin cigaba a hankali zai yiwu gwargwadon yawan glucose a cikin jini.

• Yawan maganin yana maganin yawanci 1500-2000 mg / day. Don rage tasirin sakamako daga cututtukan gastrointestinal, ya kamata a raba kashi na yau da kullum zuwa kashi 2-3. Matsakaicin adadin shine 3000 MG / rana, ya kasu kashi uku.

Yawan ragewa a hankali zai iya inganta haqurin gastrointestinal.

• Marasa lafiya waɗanda ke shan metformin a allurai na 2000-3000 mg / day za'a iya canja su zuwa 1000 mg. Matsakaicin shawarar da aka ba da shawarar ita ce 3000 MG / rana, ya kasu kashi uku.

Dangane da batun tsara canji daga shan wani wakili na hypoglycemic: dole ne ku daina shan wani magani kuma ku fara shan Metformin a cikin adadin da aka nuna a sama.

Hadawa tare da insulin:

Don cimma ingantacciyar iko na glucose na jini, ana iya amfani da metformin da insulin azaman maganin haɗuwa. Yawancin farawa na yau da kullun na Metformin 500 MG ko 850 mg shine kwamfutar hannu guda ɗaya sau 2-3 a rana, Metformin 1000 MG shine kwamfutar hannu guda 1 a rana ɗaya, yayin da aka zaɓi kashi na insulin dangane da haɗuwa da glucose a cikin jini.

Yara da matasa: a cikin yara daga shekaru 10, ana iya amfani da maganin na Metformin duka a cikin maganin ƙwaƙwalwar ƙwaƙwalwa da haɗuwa da insulin. Yawan farawa na yau da kullun shine 500 MG ko 850 MG 1 lokaci ɗaya kowace rana bayan ko lokacin abinci. Bayan kwanaki 10-15, dole ne a daidaita adadin gwargwadon yawan tattarawar glucose jini. Matsakaicin adadin yau da kullun shine 2000 MG, ya kasu kashi 2-3.

Marasa lafiya tsofaffi: saboda yiwuwar raguwa a cikin aikin koda, dole ne a zaɓi kashi na metformin a ƙarƙashin kulawar yau da kullun akan alamun alamun aiki (ƙayyade taro na creatinine a cikin ƙwayoyin magani a kalla sau 2-4 a shekara).

Tsawon likitan yana ƙaddara tsawon lokacin jiyya. Ba a bada shawarar dakatar da maganin ba tare da shawarar likita ba.

Amfani da magani

Ana ɗaukar allunan Metformin a baki.

Lokacin shan magani, ana bada shawara cewa allunan za su haɗiye allunan ba tare da an cuce su ba.

Ya kamata a yi amfani da miyagun ƙwayoyi a lokacin abinci ko kuma nan da nan bayan shi. Auki kwaya tare da isasshen ƙarfin ruwa.

Babban mahimmancin amfani da magani shine kasancewar nau'in ciwon sukari na 2 a cikin haƙuri.

Umarnin don amfani yana nuna cewa za'a iya amfani da maganin a cikin tsarin monotherapy ko kuma azaman ɓangaren hadadden farke tare da wasu jami'ai tare da kaddarorin hypoglycemic ko a hade tare da inulin.

Umarnin don amfani yana ba da damar yin amfani da miyagun ƙwayoyi a cikin yara, farawa daga shekaru 10. An yarda da amfani da miyagun ƙwayoyi don yara duka biyu a matsayin maganin monotherapy, kuma a hade tare da injections insulin.

Sigar farko lokacin shan magani shine 500 MG. Ana ba da shawarar maganin don shan sau 2-3 a rana. Idan ya cancanta, tare da ƙarin shiga, ana iya ƙara yawan kashi na ƙwayar. Increasearin yawan sigogin da aka dauka ya dogara da matakin ƙwayar glucose a cikin jiki.

Lokacin amfani da Metformin a cikin aikin maganin kulawa, ƙimar da aka ɗauka ya bambanta daga 1,500 zuwa MG 2,000 a rana. Ya kamata a raba magungunan yau da kullun zuwa sau 2-3, wannan amfani da miyagun ƙwayoyi yana nisantar bayyanar da mummunan sakamako masu illa daga ƙwayar gastrointestinal. Matsakaicin izini na gwargwado daidai da umarnin don amfani shine 3000 MG kowace rana.

Lokacin shan miyagun ƙwayoyi, ya kamata a ƙara yawan ƙwayar a hankali har sai an sami ƙimar mafi kyau, wannan dabarar zata inganta haƙurin maganin zuwa ƙwayar gastrointestinal.

Idan mai haƙuri ya fara shan Metformin bayan wani magani na hypoglycemic, to, kafin ɗaukar Metformin wani magani ya kamata a dakatar dashi gaba daya.

Lokacin amfani da miyagun ƙwayoyi a lokacin ƙuruciya, yakamata a fara magani tare da sashi na 500 MG sau ɗaya a rana. Bayan kwanaki 10-15, ana aiwatar da gwajin jini don glucose kuma, idan ya cancanta, ana daidaita yawan maganin da aka sha. Matsakaicin adadin maganin yau da kullun ga marasa lafiya a yara shine 2000 MG. Wannan kashi ya kamata ya kasu kashi biyu-biyu a kowace rana.

Idan tsofaffi ke amfani da maganin, tsofaffin hanyoyin ya kamata a aiwatar da su a ƙarƙashin tsananin kulawa daga likitocin da ke halartar. Wannan buƙatun yana kasancewa saboda gaskiyar cewa a cikin tsofaffi, haɓaka digiri daban-daban na rashin nasara na yara a cikin jiki yana yiwuwa.

Tsawon likitan da likitan halartar ya tabbatar da tsawon lokacin amfani da miyagun ƙwayoyi.

A lokacin warkarwa, magani bai kamata a katse ba tare da umarnin likitan halartar ba.