Humalog - umarnin don amfani, analogs, sake dubawa da kuma sakin siffofin (QuickPen pen syringe tare da bayani ko dakatar da Mix 25 da 50 insulin) na magani don maganin nau'in 1 da nau'in ciwon sukari na 2 a cikin manya, yara da lokacin daukar ciki

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Humalogue. Yana ba da ra'ayi daga baƙi zuwa rukunin yanar gizon - masu cin wannan magani, da kuma ra'ayoyin kwararrun likitocin game da amfani da Humalog a aikace. Babban buƙatar shine a ƙara ra'ayoyinku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta a cikin bayanin ba. Analogs na Humalog a gaban wadatattun analogues na tsarin ana amfani dasu. Amfani don lura da nau'in 1 da nau'in ciwon sukari na 2 na ciwon sukari (insulin-dogara da ciwon sukari wanda ba shi da insulin) a cikin manya, yara, har ma lokacin daukar ciki da lactation. Abun da magani.

Humalogue - analog na insulin na ɗan adam, ya bambanta da shi ta hanyar jeri na proline da linsine amino acid na raguwa a matsayi na 28 da 29 na sarkar insulin B. Idan aka kwatanta da shirye-shiryen insulin gajere, lyspro insulin ana nuna shi da sauri da kuma ƙarshen tasirin, wanda shine saboda karɓar sha daga ƙwaƙwalwar subcutaneous saboda adana tsarin monomeric na kwayoyin insulin lyspro a cikin maganin. Farawar aiki shine mintina 15 bayan gudanarwar subcutaneous, matsakaicin sakamako shine tsakanin awa 0.5 zuwa awa 2.5, tsawon lokacin aikin shine sa'o'i 3-4.

Humalog Mix shine DNA - sake zama analog na insulin ɗan adam kuma cakuda haɗuwa ne wanda aka haɗa da maganin insulin lyspro (analog ɗin mai aiki da insulin na ɗan adam) da dakatarwar insulin lyspro pro-matsakaici na ɗan adam).

Babban aikin insulin lyspro shine tsari na metabolism metabolism. Bugu da ƙari, yana da tasirin anabolic da anti-catabolic akan ƙoshin jikin mutane daban-daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.

Abun ciki

Lyspro insulin + excipients.

Pharmacokinetics

Cikakken kamfani da kuma farawar insulin ya dogara da shafin allura (ciki, cinya, gindi), kashi (girman insulin allurar), da kuma tattarawar insulin a cikin shiri. An rarraba shi ba tare da daidaituwa ba a cikin kyallen takarda. Bai ƙetare katangar ƙwarya ba kuma cikin madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya cire shi - 30-80%.

Alamu

type 1 ciwon sukari mellitus (insulin-dogara), gami da tare da rashin haƙuri ga sauran shirye-shiryen insulin, tare da hyperglycemia postprandial waɗanda ba za a iya gyara su ta hanyar wasu shirye-shiryen insulin ba, ƙarancin insulin ƙananan insulin (lalacewar insulin na cikin gida),
nau'in ciwon sukari na 2 na marasa lafiya (marasa insulin-dogara): tare da juriya ga wakilai na yawan maganganu na baki, kazalika da shan wahala na sauran shirye-shiryen insulin, rashin daidaituwa na bayan jini, lokacin aiki, cututtukan da ke shudewa.

Sakin Fom

Magani don gudanarwar ciki da karkara na sarrafa 100 IU a cikin kwatin 3 ml da aka haɗa cikin allurar QuickPen ko sirinji na alkalami.

Dakatarwa don ƙaddamarwa na 100 IU a cikin kundin 3 ml a cikin kundin QuickPen ko alkalami na alkalami (Humalog Mix 25 da 50).

Sauran nau'ikan sashi, koda Allunan ko kuma kwansonsu, babu su.

Umarnin don amfani da hanyar amfani

An saita sashi daban. Ana gudanar da insulin na Lyspro subcutaneously, intramuscularly ko intravenously 5-15 mintuna kafin cin abinci. Singleaya daga cikin kashi shine raka'a 40, an yarda da wuce haddi a cikin lokuta na musamman. Tare da monotherapy, ana gudanar da insulin Lyspro sau 4-6 a rana, a hade tare da shirye-shiryen insulin tsawan lokaci - sau 3 a rana.

Ya kamata a gudanar da miyagun ƙwayoyi a ƙarƙashin ƙasa.

M ciki da miyagun ƙwayoyi Humalog Mix an contraindicated.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya zama zazzabi a ɗakin.

Ya kamata a allurar da kashi a cikin kafada, cinya, gindi ko ciki. Yakamata a sauya wuraren allurar don kada a yi amfani da wurin guda fiye da lokaci 1 a kowane wata. Lokacin da s / ga gabatarwar miyagun ƙwayoyi Humalog, dole ne a kula don hana shigar da miyagun ƙwayoyi a cikin jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba.

Lokacin shigar da kundin a cikin injection insulin kuma yana ɗaukar allura kafin gudanarwar insulin, dole ne a kiyaye umarnin mai ƙirar insulin naúrar gudanar da aikin.

Dokoki don gabatarwar miyagun ƙwayoyi Humalog Mix

Shiri don gabatarwa

Nan da nan kafin amfani da shi, yakamata a jujjuya murfin Humalog Mix a cikin tafin hannun ya ninka sau goma kuma ya girgiza, ya juya 180 ° kuma sau goma don sake farfadowa da insulin har sai yayi kama da ruwa mai hade ko madara mai kama da juna. Shake da ƙarfi, kamar yadda wannan na iya haifar da kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi. Don sauƙaƙe hadawa, kundin ya ƙunshi karamin dutsen ado. Bai kamata a yi amfani da miyagun ƙwayoyi ba idan ya ƙunshi flakes bayan haɗuwa.

Yadda ake gudanar da maganin

Wanke hannu.
Zaɓi wurin yin allura.
Bi da fata tare da maganin rigakafi a wurin allurar (tare da allurar kai, daidai da shawarar likita).
Cire takalmin kariya daga allura.
Gyara fata ta hanyar jan shi ko adon babban falo.
Saka allura a ƙarƙashin kuma aiwatar da allurar daidai da umarnin don amfani da alkairin sirinji.
Cire allura kuma a hankali matsi da allurar site na wasu 'yan seconds. Kar a shafa wurin allurar.
Yin amfani da matattarar m abin da ke cikin allurar, kwance allurar sai a lalata shi.
Saka hula a aljihun syringe.

Side sakamako

hypoglycemia (tsananin hypoglycemia na iya haifar da asarar hankali kuma, a lokuta na musamman, ga mutuwa),
jan launi, kumburi, ko ƙaiƙayi a wurin allura (yawanci yakan ɓace cikin aan kwanaki ko makonni, a wasu yanayi waɗannan halayen ana iya haifar dasu ta hanyar dalilan da basu da nasaba da insulin, alal misali, haushi na fata ta hanyar allurar rigakafi ko ta hanyar da ba ta dace ba),
na sarrafa itching
wahalar numfashi
karancin numfashi
raguwa a cikin karfin jini,
samarin
ƙara yin gumi
haɓakar lipodystrophy a wurin allurar.

Contraindications

hawan jini,
rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Haihuwa da lactation

Har zuwa yau, ba a bayyana sakamakon insulin Lyspro akan ciki ba ko kuma yanayin tayin da jariri.

Manufar insulin far a lokacin daukar ciki shine don samun isasshen kulawar glucose. Bukatar insulin yawanci yana raguwa a cikin farkon farkon abubuwa kuma yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Matan da suka isa haihuwa yayin kamuwa da cutar siga yakamata su sanar da likita game da farawa ko kuma shirin yin ciki.

A cikin marasa lafiya da ciwon sukari mellitus yayin shayarwa, ana buƙatar daidaita sashin insulin da / ko rage cin abinci.

Umarni na musamman

Hanyar gudanarwa da aka yi nufin amfani da shi don amfani da nau'in insulin lyspro ya kamata a kiyaye shi sosai. Lokacin canja wurin marasa lafiya daga shirye-shiryen insulin mai sauri-sauri na asalin dabba zuwa insulin lispro, ana iya buƙatar daidaita sashi. Canja wurin marasa lafiya da suke karɓar insulin a cikin kashi-kashi na yau da kullun da suka wuce raka'a 100 daga nau'in insulin zuwa wani an bada shawarar a kai su asibiti.

Bukatar insulin na iya ƙaruwa yayin cuta mai taushi, tare da damuwa na damuwa, tare da haɓaka yawan adadin carbohydrates a cikin abinci, yayin ƙarin ƙarin ƙwayoyi tare da aikin hyperglycemic (ƙwayoyin thyroid, glucocorticoids, hana maganin hana haihuwa, thiazide diuretics).

Bukatar insulin na iya raguwa tare da renal da / ko gazawar hanta, tare da rage adadin carbohydrates a cikin abinci, tare da ƙara yawan motsa jiki, yayin ƙarin ƙarin magunguna tare da aikin hypoglycemic (masu hana MAO, masu hana beta-blockers, sulfonamides).

Ana iya aiwatar da gyaran hypoglycemia a cikin wani yanayi mai mahimmanci ta amfani da i / m da / ko s / c gudanar da glucagon ko iv na glucose.

Hulɗa da ƙwayoyi

Tasirin hypoglycemic na Lyspro yana haɓaka ta hanyar MAO inhibitors, masu hana beta-blockers, sulfonamides, acarbose, ethanol (barasa) da ethanol dauke da kwayoyi.

Tasirin hypoglycemic na Lyspro insulin ya rage ta glucocorticosteroids (GCS), hodar iblis, maganin hana haihuwa, thiazide diuretics, diazoxide, antidepressants na tricyclic.

Beta-blockers, clonidine, reserpine na iya rufe alamun bayyanar cututtuka na hypoglycemia.

Analogs na miyagun ƙwayoyi Humalog

Tsarin analogues na mai aiki abu: