Yadda ake amfani da Metglib?

Don Allah kafin ka sayi allunan Metglib an rufe shi cikin bauta. 2.5 mg + 400 MG, pcs 40,, Duba bayanan game da shi tare da bayani akan shafin yanar gizon hukuma na masu samarwa ko ƙayyadadden takamaiman samfurin tare da manajan kamfaninmu!

Bayanin da aka nuna akan shafin ba tayin jama'a bane. Mai sana'anta ya tanadi haƙƙin yin canje-canje a cikin ƙira, ƙira da marufi na kaya. Hotunan kaya a cikin hotunan da aka gabatar a cikin kundin adireshin a shafin zai iya bambanta da asalin.

Bayanai kan farashin kaya da aka nuna a cikin kundin adireshin a shafin zai iya bambanta da ainihin lokacin a lokacin sanya oda don samfurin da ya dace.

Mai masana'anta

Kwamfutar hannu 1 ya ƙunshi:

abubuwa masu aiki: metformin hydrochloride 400 MG, glibenclamide 2.5 MG,

tsofaffi: alli hydrogen phosphate dihydrate 50 mg, sitaci masara 45 mg, croscarmellose sodium 12 mg, sodium stearyl fumarate 3 mg, povidone 52 mg, microcrystalline cellulose 35.5 mg, fim ɗin gashi: Opadry orange 20 mg, ciki har da: hypromellose (hydroxypropyl m celyl ) 6.75 mg, hyprolose (hydroxypropyl cellulose) 6.75 mg, talc 4 MG, titanium dioxide 2.236 MG, baƙin ƙarfe baƙin ƙarfe 0.044 mg, baƙin ƙarfe ruwan rawaya 0.22 mg.

Aikin magunguna

Hadaddiyar haɗuwa da wakilai na magana da ƙwayoyin cuta guda biyu na rukuni na magunguna daban-daban: metformin da glibenclamide. Metformin yana cikin rukunin biguanides kuma yana rage yawan abubuwan glual da na postprandial a cikin jini. Metformin baya motsa insulin insulin, sabili da haka baya haifar da hypoglycemia.

Yana da matakai 4 na aikin:

- yana rage haɓakar glucose ta hanta ta hana gluconeogenesis da glycogenolysis,

- yana haɓaka hankalin masu karɓar nai zuwa insulin, yawan amfani da amfani da glucose ta sel a cikin tsokoki,

- yana jinkirta ɗaukar glucose a cikin maƙogwaron ciki,

- yana kwantar da shi ko rage nauyin jiki a cikin masu haƙuri da cutar sankarar mama.

Type 2 ciwon sukari a cikin manya:

- tare da rashin ingancin maganin motsa jiki, motsa jiki da monotherapy da suka gabata tare da tsarin metformin ko abubuwan da suka samo asali na sulfonylurea,

- don maye gurbin maganin da ya gabata tare da kwayoyi guda biyu (metformin da mai maganin sulfonylurea) a cikin marasa lafiya tare da tsayayyen tsari mai kyau na glycemia.

Contraindications

- Hypersensitivity zuwa metformin, glibenclamide ko wasu abubuwan da suka samo asali na sulfonylurea, har ma da sauran abubuwanda aka tanadar na Metglib,

- nau'in ciwon sukari na 1

- mai ciwon sukari ketoacidosis, mai ciwon sukari, mai ciwon sukari,

- gazawar koda ko kuma lalacewar aikin nahala (kyautar kere kere kasa da mil 60 / min),

- matsanancin yanayi wanda zai iya haifar da canji a cikin aikin koda: bushewar fata, matsanancin ciwo, girgiza, gudanarwar cikin jijiyoyin abubuwa na iodinated,

- Cuta mai raɗaɗi ko raunin jijiyoyin jiki wanda ke haɗuwa da raunin nama: zuciya ko gazawar numfashi, rashin ƙarfi na kwanan baya,

- haihuwa, lokacin shayarwa,

- sarrafa miconazole na lokaci daya,

- cututtuka masu kamuwa da cuta, manyan ayyukan tiyata, raunin da ya faru, konewa mai yawa da sauran yanayin da ke buƙatar maganin insulin,

- rashin shan barasa, rashin shan barasa,

- lactic acidosis (gami da tarihi),

- riko da karancin kalori (kasa da 1000 kcal / day),

- shekarun yara har zuwa shekaru 18.

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin mutanen da suka haura shekaru 60 waɗanda ke yin aiki na zahiri, wanda ke da alaƙa da haɓakar haɗarin haɓakar lactic acidosis a cikinsu.

- hauhawar jini na baya,

- cututtuka na thyroid gland shine yake (tare da uncompensated take hakkin ta aiki),

- a cikin tsofaffi sama da shekara 70 da haihuwa saboda hadarin cututtukan jini.

Side effects

Abubuwanda zasu biyo baya na iya faruwa yayin magani tare da Metglib®. Wanda aka rarrabe shi na wanda ya haifar da sakamako masu illa:

sau da yawa sau daya - appoint1 / 10 alƙawura (> 10%)

galibi daga ≥1 / 100 zuwa 1% kuma

sau da yawa - daga ≥1 / 1000 zuwa 0.1% kuma

da wuya - daga ≥1 / 10000 zuwa0.01% da

Rarraba halayen da ba a yarda da su ba daidai da lalacewar gabobi da tsarin sassan jikin mutum (kamus na likita don ƙaddamar da aikin Med-DRA).

- Take hakkin jini da tsarin lymphatic:

Wadannan abkuwar haɗari sun ɓace bayan dakatar da miyagun ƙwayoyi.

Da wuya: leukopenia da thrombocytopenia.

Da wuya sosai: agranulocytosis, hemolytic anemia, aprowia bone, da pancytopenia.

- Take hakkin tsarin rigakafi:

Da wuya sosai: girgiza anaphylactic.

Abubuwan da ke haifar da tasirin jini ga abubuwan sulfonamides da abubuwan da zasu iya haifarwa na iya faruwa.

- Rashin hankali daga metabolism da abinci mai gina jiki: Hypoglycemia.

Da wuya: ƙarancin cututtukan hepatic porphyria da cutaneous porphyria.

Da wuya sosai: lactic acidosis.

Rage yawan shan bitamin B12, tare da raguwa a cikin taro a cikin jijiyoyin jini tare da tsawaita amfani da metformin. Idan an gano megaloblastic anemia, yiwuwar yin irin wannan ilimin etiology. Disulfiram-like dauki tare da ethanol.

- Take hakkin jijiya:

Sau da yawa: ɗanɗanar damuwa da damuwa (ɗanɗanar "ƙarfe" a cikin bakin).

Rikicin gani: A farkon farawar, raunin gani na ɗan lokaci na iya faruwa saboda raguwar gulukon jini.

- Rashin damuwa na ƙwayar gastrointestinal:

Mafi yawan lokuta: tashin zuciya, amai, gudawa, ciwon ciki da rashin ci. Wadannan bayyanar cututtuka sun fi yawa a farkon magani kuma a mafi yawan lokuta suna ba da nasu. Don hana ci gaban waɗannan bayyanar cututtuka, ana bada shawara don ɗaukar ƙwayar a cikin allurai 2 ko 3, jinkirin karuwa a cikin adadin maganin yana inganta haƙurinsa.

- Rashin lafiya daga hanta da hancin biliary:

Da wuya sosai: alamomin aikin hanta masu rauni ko cutar hepatitis waɗanda ke buƙatar dakatar da jiyya.

Rashin lafiya daga fata da ƙananan kasusuwa:

Da wuya: halayen fata, irin su: pruritus, urticaria, fitsarin maculopapular.

Da wuya sosai: fata ko cututtukan cututtukan ƙwayar cuta na visas, cututtukan polymorphic, erythema na polymorphic, exfoliative dermatitis, hotoensitivity.

- Lab Labour da kayan aikin:

A lokaci-lokaci: karuwa a cikin taro na urea da creatinine a cikin magani daga matsakaici zuwa matsakaici.

Da wuya sosai: hyponatremia.

Haɗa kai

Mai dangantaka da Amfani da Glibenclamide

Miconazole na iya tayar da haɓakar ƙwayar cuta (har zuwa haɓaka ƙwayar cuta).

Metformin mai dangantaka

Iodine-dauke da wakilai masu bambanci: dangane da aikin koda, ya kamata a dakatar da miyagun ƙwayoyi awanni 48 kafin ko bayan gudanarwar kwastomomin masu dauke da aidin.

Hadin gwiwar da aka ba da shawarar: An haɗu da yin amfani da abubuwan samo asali na sulfonylurea

Ethanol: amsawar disulfiram-kamar (rashin yarda ethanol) da wuya a lura sosai yayin shan ethanol da glibenclamide. Ethanol na iya haɓaka sakamako na hypoglycemic (ta hana halayen ramuwar gayya ko jinkirta rashin aiki), wanda zai iya ba da gudummawa ga haɓakar ƙwaƙwalwar ƙwayar cuta. Yayin jiyya tare da Metglib®, ya kamata a guji barasa da magungunan da ke ɗauke da ethanol. Phenylbutazone yana ƙaruwa sakamakon hypoglycemic na abubuwan da suka samo asali na sulfonylurea (maye gurbin abubuwan da ake buƙata na gidajen sinadarai a wuraren da suke ɗaukar furotin da / ko rage fitar da isowar su) Zai fi kyau a yi amfani da wasu magungunan anti-mai kumburi wanda ke nuna rashin haɗin kai, ko don faɗakarwa mara lafiya game da buƙatar sarrafa kansa da ciwon kai, idan ya cancanta, ya kamata a daidaita sashi idan aka yi amfani da maganin anti-mai kumburi tare kuma bayan an dakatar dashi.

An haɗu da shi tare da yin amfani da glibenclamide

Bozentan a hade tare da glibenclamide yana ƙara haɗarin hepatotoxicity.

An ba da shawarar ku guji shan waɗannan kwayoyi a lokaci guda. Har ila yau, sakamakon hypoglycemic na glibenclamide na iya raguwa.

Metformin mai dangantaka

Ethanol: Hadarin kamuwa da cutar lactic acidosis yana ƙaruwa tare da matsanancin buguwa na giya, musamman idan akwai batun yunwar abinci, ko abinci mai ƙoshin abinci, ko gazawar hanta. Yayin jiyya tare da Metglib®, ya kamata a guji barasa da magungunan da ke ɗauke da ethanol.

Yadda ake ɗauka, hanya ta gudanarwa da sashi

Adadin da regimen na miyagun ƙwayoyi, har da tsawon lokacin kulawa, an ƙaddara ta likita mai halartar, da farko, dangane da yanayin metabolism na haƙuri, dangane da maida hankali na glucose a cikin jini. A matsayinka na mai mulkin, kashi na farko shine allunan 1-2 a kowace rana tare da babban abincin, tare da zaɓi na hankali a hankali har sai an sami daidaituwa na daidaituwa na glucose a cikin jini na jini. Matsakaicin adadin Metglib® na yau da kullun shine Allunan 6, waɗanda aka kasu kashi uku.

Yawan abin sama da ya kamata

Game da yawan abin sama da ya kamata, ƙwanƙwasa jini na iya haɓaka saboda kasancewar sinadarin sulfonylurea a cikin shirye-shiryen.

Matsakaici zuwa matsakaiciyar alamu na hypoglycemia ba tare da asarar hankali da kuma bayyanar cututtuka na jijiyoyi ba za'a iya gyara su ta hanyar amfani da sukari nan da nan. Wajibi ne don aiwatar da daidaitawa da / ko canza abincin. Abunda ya faru na mummunan sakamako na hypoglycemic a cikin marasa lafiya da ciwon sukari, tare da coma, paroxysm, ko wasu rikicewar jijiyoyin jini, suna buƙatar kulawa ta gaggawa na likita. Gudanar da maganin warwarewar nakasar ya zama dole nan da nan bayan ganewar asali ko tuhuma da zazzabin cizon sauro, kafin zuwa asibiti mai haƙuri. Bayan murmurewa, ya zama dole a ba mai haƙuri abincin da ke da wadataccen ƙwayoyin carbohydrates cikin sauki (don guje wa sake haɓakar cutar sanƙara).

Rashin maganin plasma glibenclamide na iya karuwa a cikin marasa lafiya da cutar hanta. Tunda glibenclamide yana daure da garkuwar jini, magungunan ba a kebe su ba lokacin dialysis.

Prolongara yawan shan ruwa ko kasancewar haɗarin abubuwan haɗari na iya tayar da haɓakar lactic acidosis, tunda metformin wani ɓangare ne na miyagun ƙwayoyi.

Lactic acidosis yanayi ne wanda ke buƙatar kulawa da lafiya na gaggawa, lura da lactic acidosis ya kamata a gudanar da shi a asibiti. Hanyar magani mafi inganci don cire lactate da metformin shine hemodialysis.

Sunan kasa da kasa mai zaman kansa

Glibenclamide + Metformin (Glibenclamide + Metformin)

An hada magungunan a cikin rukunin magungunan da ke tsara glucose na jini.

A10BD02. Metformin a hade tare da sulfonamides

Saki siffofin da abun da ke ciki

Magungunan suna cikin nau'ikan allunan. Kamar yadda manyan abubuwan da ke aiki, ana amfani da metformin hydrochloride da glibenclamide. Maƙallansu a cikin kwamfutar hannu 1: 400 MG da 2.5 MG. Sauran abubuwan haɗin da ba su nuna aikin hypoglycemic:

• alli hydrogen phosphate foda,
• sitaci masara
• croscarmellose sodium
• sodium kararayi fumarate,
• povidone
• microcrystalline cellulose.

Ana samfur ɗin a cikin fakiti na sel guda 40.

Magungunan suna cikin nau'ikan allunan.

Pharmacokinetics

Cutar glibenclamide yayin da ta shiga narkewar abinci shine kashi 95%. Don awa 4, ana samun mafi girman alamar ayyukan. Amfanin wannan fili shine kusan kusancewar da yake da shi ga furotin plasma (har zuwa kashi 99%). Wani yanki mai mahimmanci na glibenclamide an canza shi a cikin hanta, sakamakon wanda aka kirkiro metabolites 2, wanda baya nuna aiki kuma an keɓance shi ta cikin hanji, har da kodan. Wannan tsari yana ɗaukar tsawon awowi 4 zuwa 11, wanda yanayin ƙayyadaddun ƙwaƙwalwar jiki ya ƙaddara, sashi na kayan aiki, kasancewar wasu abubuwan cutar.

Ana amfani da Metformin da kadan kadan, bioavailability dinsa bai wuce kashi 60% ba. Wannan sinadarin ya kai ga mafi girman aikinsa da sauri fiye da glibenclamide Don haka, mafi girman tasirin metformin yana da tabbas awa 2.5 bayan shan maganin.

Wannan fili yana da raguwa - raguwa mai mahimmanci a cikin saurin aiki yayin cin abinci. Metformin bashi da ikon daure wa garkuwar jini. Abubuwan da ba'a canza su ba, kamar yadda rauni rauni canza. Kodan tana da alhakin fitar ta.

Metformin bashi da ikon daure wa garkuwar jini.

Alamu don amfani

Babban manufar shine a daidaita yanayin a cikin nau'in ciwon sukari na 2.

Ayyuka masu zuwa suna gudana:

• Canza magani na tsohuwar tsari a cikin marasa lafiya da matakan glucose mai sarrafawa,
• samar da sakamako a kan asalin cutar rashin amfanin magani, motsa jiki a jiyya ga masu fama da kiba.

Tare da kulawa

Yawancin dangi masu alaƙa da aka lura waɗanda ke buƙatar yin amfani da ƙwaƙwalwar hankali:

• zazzabi
• rage aiki na ciwon hakarkari,
• yanayin pathological tare da rusa mahaɗa ta glandar thyroid,
• kasawar rashin ƙarfi.

Tare da ciwon sukari

Umarnin don amfani da Metglib:

• a farkon matakin jiyya, an bada shawarar shan 1-2 Allunan a rana,
• daga baya, yawan maganin yau da kullun yana canzawa, wanda ya dogara da matakin glucose a cikin jini, kuma yana da mahimmanci don samun sakamako mai ɗorewa.

a farkon matakin jiyya, ana bada shawara don ɗaukar allunan 1-2 a rana.

Matsakaicin adadin izinin magani a kowace rana ga masu ciwon sukari na 2 shine allunan 6. Kuma ba za ku iya ɗaukar su ba a lokaci guda. Wajibi ne don rarraba ƙayyadadden adadin zuwa allurai 3 tare da madaidaiciyar tazara.

Don asarar nauyi

An lura cewa yin amfani da abubuwa (metformin da glibenclamide), waɗanda suke ɓangare na Metglib, suna ba da gudummawa ga rage kiba mai yawa. A shawarar da aka bada shawarar a rana shine allunan 3. An karɓa a daidai jinkiri. Aikin tilas shine kwana 20. Don hana bayyanar nauyin wuce kima, ana rage kashi zuwa 200 MG sau ɗaya, adadin yau da kullun shine 600 MG.

Magungunan ba ya samar da sakamakon da ake so ba tare da taimakon taimako ba. Abubuwan da suke cikin abubuwan sunadaran suna taimakawa ne kawai don hana juyar da makamashi zuwa kitse na jiki.

Don guje wa karuwa a cikin yawan kitse, ana buƙatar ƙara yawan aiki na jiki da daidaita abinci mai gina jiki tare da amfani da miyagun ƙwayoyi.

Yi amfani da lokacin daukar ciki da lactation

An haramta amfani da miyagun ƙwayoyi don amfani a lokacin lokacin shayarwa da shayarwa. Abubuwan da ke aiki suna shiga cikin madarar uwar. Idan akwai bukatar yin amfani da wannan magani a lokacin lactation da kuma shirin daukar ciki, za ayi aikin insulin.

An haramta amfani da miyagun ƙwayoyi don amfani a lokacin lokacin shayarwa da shayarwa.

Wanene aka wajabta maganin?

Yaduwar Metglib yana da nau'in ciwon sukari na musamman 2. Haka kuma, an tsara maganin ba a farkon cutar ba, amma tare da ci gabanta. A farkon ciwon sukari, yawancin marasa lafiya sun ba da tabbacin juriya ga insulin, kuma babu canje-canje ko ƙima a cikin ƙirar insulin. Isasshen magani a wannan matakin shine karancin abinci mai gauraye, motsa jiki, da kuma metformin. Ana buƙatar Metglib lokacin da karancin insulin.A matsakaici, wannan cuta ta bayyana shekaru 5 bayan ƙaruwa na farko a cikin sukari.

Za'a iya tsara magunguna biyu na metglib:

• idan magani na baya baya bayarwa ko ya wuce lokaci ya daina bayar da diyya ga masu cutar siga,
• kai tsaye bayan bayyanar cututtuka na nau'in ciwon sukari na 2, idan mai haƙuri yana da isasshen sukari (> 11). Bayan daidaituwar nauyi da raguwa a cikin juriya na insulin, akwai babban yiwuwar cewa sashin Metglib zai zama ragewa ko ma kawai zuwa ga Metformin,
• idan gwaje-gwaje na C-peptide ko insulin sun kasance ƙasa da al'ada, ba tare da la’akari da tsawon yawan ciwon suga ba,
• don sauƙin amfani, masu ciwon sukari waɗanda ke shan kwayoyi biyu, glibenclamide da metformin. Shan Metglib yana ba ku damar rage adadin allunan. A cewar masu ciwon sukari, wannan yana rage haɗarin manta da shan maganin.

Yadda ake ɗaukar Metglib

Metglib sha a lokaci guda kamar abinci. Magungunan yana da buƙatu na musamman don abubuwan samfuran. A cikin ciwon sukari na mellitus, carbohydrates ya kamata ya kasance a cikin kowane abinci, sashin galibinsu ya kamata ya sami ƙarancin glycemic index.

Tare da karuwa da yawan allunan, sun kasu kashi biyu (safe, maraice), sannan kuma zuwa allurai 3.

Jerin sakamako masu illa

Jerin sakamakon da ba a ke so wanda zai iya haifar da shan Metglib:

Likita na Kimiyyar Kimiyya, Shugaban Cibiyar Nazarin Diabetology - Tatyana Yakovleva

Na yi shekaru da yawa ina nazarin ciwon sukari. Yana da ban tsoro yayin da mutane da yawa suka mutu, har ma da yawa suna zama masu rauni saboda cutar sankara.

Na yi hanzarin ba da labari mai daɗi - Cibiyar Binciken Endocrinological na Kwalejin Kimiyya ta Rasha ta sami nasarar inganta maganin da ke warkar da ciwon sukari gaba ɗaya. A yanzu, ingancin wannan magani yana gab da kashi 98%.

Wani albishir: Ma'aikatar Lafiya ta tabbatar da ɗaukar wani shiri na musamman wanda zai biya diyyar magunguna mai yawa. A Rasha, masu ciwon sukari har sai 18 ga Mayu (m) samun shi - Don kawai 147 rubles!

Mafi tasirin sakamako na Metglib ana kiranta hypoglycemia. Abunda ya faru ya dogara ne akan ayyukan mai haƙuri da ciwon suga, don haka haɗarinsa bashi yiwuwa a lissafa. Don hana saukad da sukari, kuna buƙatar cin carbohydrates a ko'ina cikin rana, kada ku tsallake abinci, ku rama nauyin abinci na carbohydrate na dogon lokaci, kuna iya buƙatar kayan ciye-ciye a daidai lokacin azuzuwan. Idan waɗannan matakan ba su taimaka ba, zai fi kyau maye gurbin Metglib da magungunan da ba su da kyau.

Yi amfani da tsufa

Ya kamata a guji yin amfani da Metglib idan mai haƙuri ya shiga aiki na zahiri. A wannan yanayin, akwai haɗarin lactic acidosis. Irin waɗannan ƙuntatawa suna dacewa ga marasa lafiya waɗanda shekarunsu suka wuce 60. Bugu da kari, yakamata a yi taka tsantsan wajen lura da tsofaffi marassa lafiya daga shekaru 70 ko sama da haka. Wannan na iya haifar da ci gaban haila.

Aikace-aikace don aikin hanta mai rauni

An haramta amfani da miyagun ƙwayoyi don amfani cikin rashin isa ga aikin wannan jikin. Yi la'akari da matakin creatinine (ƙayyade iyakancewar wannan alamar a cikin maza shine 135 mmol / l, a cikin mata - 110 mmol / l).

An haramta amfani da miyagun ƙwayoyi don amfani idan akwai haɗarin hanta.

Amfani da barasa

Magunguna a cikin tambaya suna ba da gudummawa ga bayyanar mummunan sakamako a ƙarƙashin rinjayar ethanol da ke ƙunshe cikin giya. Bugu da ƙari, akwai karuwa a cikin tasirin Metglib a kan asalin amfani da barasa, wanda zai haifar da rikitarwa.

M kalmomi tare da wannan abun da ke ciki:

• Gluconorm,
• Glibomet,
• Glucovans, amma a wannan yanayin, sashi na metformin yana da girma - 500 MG,
• Garfin Metglib (adadin metformin - 500 MG).

Maganin ƙwayar cuta ta gluconorm.
Analogue na miyagun ƙwayoyi shine Glibomet.
Glucovans maganin kwayoyi.
analogue na miyagun ƙwayoyi Metglib Force.