HakanBankada

Magungunan ba da mahimmanci yana hana ayyukan cyclooxygenases 1 da 2, waɗanda ke ɗaukar aiki a cikin aikin haɗin prostaglandin (haifar kumburi da haifar da ciwo).

Allunan thrombopol suna da farfadowa, anti-mai kumburi, tasirin antipyretic.

Bangaren mai aiki shine Acetylsalicylic acid.

Rage raguwar prostaglandins a ciki zazzabin cibiyar yana haifar da raguwa cikin zafin jiki saboda karuwar gumi da narkewar fata sanyin jiki. Sakamakon tasiri na tsakiya da na yanki na babban ɓangaren, ana samun sakamako na analgesic.

Magungunan yana rage aiki thrombosis saboda hanawar sinadarin na thromboxane A2 a cikin sel jini ta platelet. Magungunan yana rage jinkirin haɗuwa da haɗakar platelet.

Nasara da taimakon miyagun ƙwayoyi Thrombopol (kashi ɗaya) sakamako na antitinlet sami ceto 7 kwana. A cikin marasa lafiya da angina mai tsayayye, ƙwayar ta rage haɗarin infarction myocardial, mace-mace.

Ana amfani da maganin don rigakafin farko da sakandare na infarction na zuciya.

Kullum kashi 6 na ƙara lokacin prothrombin, yana hana aikin prothrombin a cikin hanta hanta.

A ƙarƙashin aikin acetylsalicylic acid, yawan abubuwan coagulation yana raguwa (2,7,9,10), yawan ƙwayar fibrinolytic yana ƙaruwa.

A lokacin ayyukan tiyata, miyagun ƙwayoyi suna ƙaruwa da yawan rikituttukan basur, yana ƙaruwa da yawan zub da jini.

Magungunan Thrombopol yana haɓaka aikin motsa jiki uric acid (Tsarin sake sarrafa uric acid a cikin kodan yana da damuwa).

Alamu don amfani

An wajabta magunguna don taimako ciwo mai raɗaɗi (m, matsakaici) na asali daban-daban: ciwon hakori, ciwon kai, ciwon kai, neuralgia, algodismenorea, radicular syndrome, lumbago, myalgia, arthralgia, ciwon kai tare da cire ciwo mai barasa.

Ana amfani da miyagun ƙwayoyi don cutar febrile a kan tushen na cutar da kumburi cuta.

Contraindications

Umarnin don amfani da thrombopol baya bayar da shawarar rubuta magani don rashin haƙuri ga acid na acetylsalicylic, tare da basur na maganin basurfitsari na hanji, tare da sauye-sauye da canje-canje a cikin tsarin narkewa a cikin matsananciyar matsala, tare da maganin asma (wani nau'in da ke haifar da yawan maganin salicylates da magunguna na NSAID), tare da jiyya na lokaci daya. kashiwa a sashi na 15 na mako daya ko fiye.

Allunan magani na Thrombopol ba'a ba su izini don shaƙatawa ba, yayin shayarwa. An sanya maganin a cikin yara.

Side effects

Thrombopol na iya haifar da tashin zuciya, Reye ciwo (ci gaban hanta kasawa a tare tare da hanzari m m mai hanta da kuma encephalopathy concomitant), amsawar rashin lafiyan (a cikin hanyar bronchospasm, angioedema da amai da fata), zawo, amai, thrombocytopenia, gastralgia, yawan ci, leukopenia.

Dogon lokaci zai iya haifar da ciwon kai, tsananin farin ciki, zub da jini, hauhawar jini, yashwa da raunuka na tsarin narkewar abinci, vomiting, bronchospasm, tinnitus, da kuma raguwar jijiyoyin gani. Jaka, hargitsi na gani, kumburi, ƙara alamun bayyanar zuciya, maganin ciwon hanjinephrotic syndrome, m rashin lafiya na koda, papillary necrosis, prerenal azotemia tare da hypercalcemia da hypercreatininemia, ƙara enzymes hanta.

Thrombopol, umarnin don amfani (Hanyar da sashi)

An dauki Thrombopol a baki. Anti-kumburi da analgesic effects ana aiki da allurai na miyagun ƙwayoyi fiye da 400-500 MG.

Tare da ciwo da cututtukan febrile suna sanya gilashin 0.5-1 a kowace rana (allurai 3).

A hanya na likita ba kamata fiye da makonni 2. Singleari ɗaya don magungunan magungunan ƙwayoyin cuta shine 0.25-1 grams (allurai 3-4 kowace rana).

Yawan abin sama da ya kamata

Yawancin alamun bayyanar cututtuka: amai, tashin zuciya, saurin numfashi, tinnitus, ji da gani cuta, ciwon kai, amai. A cikin kashi na kayan aiki mai aiki fiye da 500 MG a kowace kilogiram, mummunan sakamako mai yiwuwa ne.

Kurkura ciki, sa matsi, ɗauki gawayi. Ba za ku iya ɗaukar barbiturates ba. Babu maganin rigakafi.

Haɗa kai

Thrombopol yana da ikon inganta tasirin mai guba kashiwarage shikeɓaɓɓen izini.

Magungunan yana inganta tasirin heparin, magungunan narkewa, kai tsaye anticoagulantswakokin rashin lafiya, jami'ai, karafarinisulfonamides

Acetylsalicylic acid yana rage tasirin magungunan abinci (furosemide, spironalokton), magungunan antihypertensive, magungunan uricosuric(sulfinpyrazone, benzbromarone).

Ethanol-dauke da shirye-shirye, ethanol kanta da glucocorticosteroids ƙara lalata lahani da miyagun ƙwayoyi a bangon mucous na narkewa, wanda zai haifar da zubar jini na ciki.

Thrombopol yana haɓaka matakin barbiturates, digoxin da gishiri na lithium a cikin jini.

Kasancewa baya raguwa tare da magani na lokaci daya antacids.

Magungunan Myelotoxic suna haɓaka tasirin bashin jini na thrombopol.

Umarni na musamman

Hanyar ɗaukar Acetylsalicylic acid don cimma sakamako na farfesa ba tare da tuntuɓar likita ba ya kamata ya wuce kwanaki 5.

Ba a ba da umarnin Thrombopol bana ciwon maɗamfari myocarditisrheumatoid arthritis, rheumatism, pericarditis da rheumatic chorea.

An soke maganin a cikin kwanaki 5-7 kafin yiwuwar maganin tiyata.

Dogaro jiyya na bukatar gwajin jinin haila na wajibi da kuma lura da kirga jini.

A cikin yara, shan Thrombopol na iya haifar da cututtukan Reye (haɓaka girman hanta, haɓakar lokacin encephalopathy, tsawanta, matsanancin rashin maye).

Lokaci guda na magani na magunguna waɗanda ke hana acidity na ruwan 'ya'yan itace na ciki, na iya rage tasiri mai haɓakar tasirin acetylsalicylic acid akan bangon mucous na tsarin narkewa.

Thrombopol halayen ne tasirin teratogenic (wanda aka kumshe cikin lokaci na ductus arteriosus, sharewa babban gida da sauran canje-canje a cikin tayi).

A cikin marasa lafiya da gout, miyagun ƙwayoyi na iya haifar da mummunar hari saboda raguwa a cikin excication uric acid yayin ɗaukar Acetylsalicylic acid.

Ana buƙatar cikakken ƙin shan giya mai ɗauke da ruwan sha a duk tsawon lokacin aikin jiyya.

Yadda ake amfani: sashi da hanya na jiyya

A ciki, sa'o'i 1-2 bayan cin abinci, lokaci 1 a rana.

Kwamfutar hannu ta shirye-shiryen TromboMag an haɗiye ta gaba ɗaya (ana iya ci ko a ɗanɗana), a wanke da ruwa.

An yi nufin amfani da miyagun ƙwayoyi don tsawan amfani. Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Rigakafin farko na cututtukan zuciya, irin su thrombosis da kasala na zuciya, a gaban abubuwanda ke haifar da hadari (alal misali ciwon sukari, ciwon suga, hauhawar jini, kiba, shan sigari, tsufa)

A ranar farko - kwamfutar hannu 1 dauke da 150 MG na acetylsalicylic acid, to 1 kwamfutar hannu 1 dauke da 75 MG na acetylsalicylic acid.

Yin rigakafin infarction na zuciya daga jijiyoyin jini da thrombosis na jini

1 kwamfutar hannu wanda ya ƙunshi 75 MG ko 150 MG na acetylsalicylic acid.

1 kwamfutar hannu wanda ya ƙunshi 75 MG ko 150 MG na acetylsalicylic acid.

Yin rigakafin thromboembolism bayan tiyata na jijiyoyin jini (misali, na jijiya mara jijiyoyin zuciya, da kuma jijiyoyin zuciya jijiya)

1 kwamfutar hannu wanda ya ƙunshi 75 MG ko 150 MG na acetylsalicylic acid.

Idan ka rasa ɗayan ko fiye na magungunan ThromboMag, dole ne ku ɗauki kashi da aka rasa na maganin da zarar mai haƙuri ya tuna da wannan. Don gujewa ninkawa kashi, bai kamata ku ɗauki kwamfutar da aka rasa ba idan lokacin shan magani na gaba yana gabatowa.

Ba'a lura da alamun daidaituwa na aiki yayin gudanarwa na farko ko kuma dakatar da miyagun ƙwayoyi ba.

Aikin magunguna

Hanyar antiplatelet na aikin acetylsalicylic acid (ASA) ya dogara ne akan hanawar cyclooxygenase enzyme (COX-1), sakamakon abin da aka toshe kwayar cutar thromboxane A2 kuma an dakatar da tattarawar platelet.

Sakamakon rigakafin haɗakarwa shine mafi yawanci aka ambata a cikin platelet, tunda ba su da ikon sake haɗawa da COX. An yi imanin cewa ASA tana da wasu hanyoyin da za su iya magance haɗarin platelet, wanda ke faɗaɗa girman ta a cikin cututtukan jijiyoyin jiki daban-daban. Hakanan ASA yana da magungunan anti-inflammatory, antipyretic da sakamako na analgesic.

Magnesium hydroxide - maganin antacid, yana rage tasirin fushin ASA akan mucosa na ciki.

Haihuwa da lactation

Yin amfani da salicylates a cikin allurai masu girma a cikin farkon farkon haihuwa yana da alaƙa da haɓakar mitar nakasar tayi (rarrabuwa da babba, lakar zuciya). Yin amfani da miyagun ƙwayoyi a farkon watanni uku na ciki yana contraindicated. A cikin kashi biyu na ciki na ciki, za a iya ba da umarnin miyagun ƙwayoyi ne kawai yin la'akari da ƙayyadaddun kima na rabo na amfani da jiyya ga mahaifiya da kuma haɗarin haɗari ga tayin, a cikin allurai da basu wuce 150 MG / day a cikin wani ɗan gajeren lokaci. A cikin kashi uku na ciki na ciki, salicylates a cikin babban kashi (fiye da 300 MG / rana) yana haifar da hanawar aiki, rufewar hanji na hanji a cikin tayin, ƙara yawan zubar jini a cikin mahaifiya da tayin, kuma yin amfani da shi nan da nan kafin haihuwar na iya haifar da zubar jini cikin mahaifa, musamman a cikin jarirai. Yin amfani da miyagun ƙwayoyi a cikin watanni uku na ciki ya haɗu.

Salicylates da metabolites ɗin su a cikin adadi kaɗan sun shiga cikin madara. Bayanai na asibiti don tantance amincin acetylsalicylic acid yayin shayarwa ba isasshe ba. Kafin rubuta acetylsalicylic acid a lokacin shayarwa, ƙididdigar amfanin maganin maganin ƙwaƙwalwa da kuma haɗarin haɗari ga jarirai ya kamata a tantance. Yawan cin abinci mai gishiri a lokacin shayarwa baya tare da haɓakar halayen da ake samu a cikin yaro kuma baya buƙatar daina shayarwa. Koyaya, idan kuna buƙatar amfani da maganin na dogon lokaci, ya kamata a dakatar da shan nono nan da nan.

Tsarin ilimin rayuwa (ICD-10)

Sashi da gudanarwa

A ciki 1-2 bayan cin abinci, lokaci 1 a rana.

Kwamfutar hannu ta shirye-shiryen TromboMag ® an haɗiye ta duka (ana iya ci ko a ɗanɗana), a wanke da ruwa.

Magungunan TromboMag ® anyi shi don amfani na dogon lokaci. Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Rigakafin farko na cututtukan zuciya, irin su thrombosis da matsanancin rauni na zuciya, a gaban abubuwanda ke haifar da haɗari (alal misali ciwon sukari, hauhawar jini, hauhawar jini, kiba, shan sigari, tsufa). A ranar farko - 1 tebur. ThromboMag ® shiri wanda ya ƙunshi 150 MG na acetylsalicylic acid, to - 1 tebur. ThromboMag ® dauke da 75 MG na acetylsalicylic acid.

Yin rigakafin yaduwar cututtukan zuciya da kuma jijiyoyin jini. Shafin 1. ThromboMag ® dauke da 75 ko 150 MG na acetylsalicylic acid.

Babu matsala angina pectoris. Shafin 1. ThromboMag ® dauke da 75 ko 150 MG na acetylsalicylic acid.

Yin rigakafin thromboembolism bayan tiyata na jijiyoyin jini (misali, na jijiya mara jijiyoyin zuciya, da kuma jijiyoyin bugun zuciya jijiya). Shafin 1. ThromboMag ® dauke da 75 ko 150 MG na acetylsalicylic acid.

Idan ka rasa ɗayan ko sama da ɗayan shirye-shiryen TromboMag must, dole ne ku sha kashi da aka rasa da zaran likitan ya tuna da wannan. Don gujewa ninkawa kashi, bai kamata ku ɗauki kwamfutar da aka rasa ba idan lokacin shan magani na gaba yana gabatowa.

Ba'a lura da alamun daidaituwa na aiki yayin gudanarwa na farko ko kuma dakatar da miyagun ƙwayoyi ba.

Fom ɗin saki

Allunan da aka sanya fim ɗin 75 MG + 15.2 MG ko 150 MG + 30.39 MG. Shafin 10. a cikin firi-firi na marufi fitila da aka buga da aluminiƙar tsare da allon almara, an rufe PVC da fim din polyamide. An sanya blister 3 ko 10 a cikin kwali na kwali.

Mai masana'anta

Hemofarm LLC, Rasha. 249030, Yankin Kaluga, Obninsk, Kievskoye sh., 62.

Waya: (48439) 90-500, fax: (48439) 90-525.

Suna da adireshin ofishin shari'a wanda sunan sa aka ba da takardar rajista / kungiyar da ke karɓar iƙirarin. Nizhpharm JSC, Russia, 603950, Nizhny Novgorod, GSP-459, ul. Salgan, 7.

Waya: (831) 278-80-88, fax: (831) 430-72-28.

Pharmacokinetics

Sau ɗaya a cikin gastrointestinal fili, ASA yana tunawa da sauri kuma kusan gaba daya. Tare da shigowa lokaci guda, sha zai rage gudu. Yana halakar da ƙwayar metabolism yayin sha.

A lokacin da bayan sha, ASA an biotransformed zuwa cikin babban metabolite - salicylic acid, wanda kuma metabolized yana ƙarƙashin tasirin enzyme (galibi a cikin hanta), sakamakon haifar da metabolites kamar salicylic acid, glucuronide salicylate da phenyl salicylate, wanda aka samo a cikin ruwa mai yawa da kyallen takarda. A cikin mata, metabolism na ASA yana da hankali (saboda ƙananan ayyukan enzymes a cikin ƙwayar magani).

Matsakaicin ƙwayar plasma na ASA ya kai minti 10-20 bayan ɗaukar ThromboMag a baki, salicylic acid - bayan mintuna 18-120. Acetylsalicylic da salicylic acid sun ɗaura zuwa babban digiri ga ƙwayoyin plasma kuma ana rarraba su cikin sauri cikin jiki. Abin da ke ɗaure na salicylic acid zuwa ƙwayoyin plasma ba layi bane kuma ya dogara da taro. A ƙananan taro (0.4 mg / ml) - har zuwa 75%.

A bioavailability na acetylsalicylic acid shine kashi 50-68%, salicylic acid - 80-100%. Acid na Salicylic ya ratsa katangar mahaifa kuma ya shiga cikin nono.

A cikin jarirai, mata masu juna biyu, da marasa lafiya tare da gazawar koda, salicylates na iya kawar da bilirubin daga haɗuwa da albumin kuma yana haifar da haɓakar eniriflopathy bilirubin.

ASA da metabolites dinsu sune ke rabuwa da kodan. Lokacin ɗaukar ThromboMag a cikin ƙananan allurai, rabin-rayuwar (T_½) plasma acetylsalicylic acid shine mintina 15-20, salicylic acid shine 120-180 min. Lokacin ɗaukar miyagun ƙwayoyi a cikin allurai masu yawa saboda jikewa na tsarin enzymatic T_½ ƙara ƙaruwa.

Ba kamar sauran salicylates ba, ASA mara amfani da ruwa mai narkewa ba ya tarawa a cikin jini yayin shan shi akai-akai. Tare da aikin renal na al'ada, kashi 80-100% na maganin ASA an cire shi ta hanyar kodan a cikin sa'o'i 24-72.

Hydroxide wanda yake bangare na magnesium na ThromboMag baya tasiri a bioavailability na ASA.

Hulɗa da ƙwayoyi

Tasirin antiplatelet na ASA ya rage ta: colestyramine, ibuprofen, glucocorticosteroids da antacids waɗanda ke ɗauke da magnesium da / ko aluminum hydroxide.

ASA tana haɓaka sakamako kuma yana ƙara haɗarin haɗari mai guba lokacin amfani dashi lokaci guda tare da methotrexate (rage rage ƙwayar renal dinsa da kuma kawar da shi daga kariyar jini ta jini) da kuma sinadarin valproic (ƙaurace shi daga ƙwayar plasma).

Kamar sauran NSAIDs, a cikin babban allurai, ASA na iya rage tasirin sakamako na diuretics (hana haɓaka sinadarin na koda na rage ƙwayoyin cuta) da magungunan antihypertensive. Musamman, saboda gasa mai karfi na aikin prostacyclin, ƙwayar za ta iya rage tasirin maganin angiotensin da ke canza masu inzyme (ACE).

A cikin ƙananan allurai, ASA tana raunana sakamako na wakilai na uricosuric (sulfinpyrazone, probenecid, benzbromarone), suna yin gasa da hana ruwa tubular koda na uric acid.

ASA tana haɓaka sakamako kuma yana ƙara haɗarin sakamako masu illa na magunguna masu zuwa:

• sauran NSAIDs da narcotic analgesics (saboda aiki tare na aiki),
• carbonic anhydrase inhibitors, alal misali, acetazolamide (haɓakar acidosis mai ƙarfi da haɓaka sakamako mai guba akan tsarin juyayi na tsakiya yana yiwuwa),
• digoxin da lithium (excretion dinsu na raguwa, raguwar plasma yana ƙaruwa, yakamata a kula da yawan plasma kuma yakamata ayi gyare-gyare gwargwado),
• zabin serotonin na reuptake inhibitors, wanda ya hada da paroxetine da sertraline (saboda aikin synergistic, tare da haɓakar haɗarin zub da jini a cikin ƙwayar gastrointestinal),
• wakilan antiplatelet (gami da Clopidogrel da dipyridamole), maganin rashin daidaituwa (wanda ya hada da ticlopidine da warfarin), heparin, magungunan thrombolytic (saboda cunkoson garkuwar plasma da daidaituwa na babban tasirin cutar),
• oral hypoglycemic jami'ai, sune abubuwan samo asali na sulfonylurea, da insulin ASA a cikin allurai na yau da kullun (fiye da 2000 mg) kanta tana da kaddarorin hypoglycemic, sannan kuma tana fitar da abubuwan da ake amfani da su na sulfonylurea daga haɗin tare da kariyar plasma,
• sulfonamides, wanda ya hada da co-trimoxazole (ASA yana kawar dasu daga sadarwa tare da kariyar plasma kuma yana kara yawan damuwa a cikin jini),
• ethanol (tasirin lalacewarsa a cikin mucous membrane na narkewa shine ke haɓaka, kuma haɗarin zubar jini na haɓaka).

Analogs na ThromboMag sune: Cardiomagnyl, Thrombital, Thrombital Forte, Phasostabil.

Alamar magunguna

Prophylaxis na farko na cututtukan zuciya kamar su thrombosis da rauni na zuciya tare da abubuwan haɗari (misali, ciwon sukari mellitus, hyperlipidemia, hauhawar jini, kiba, shan sigari, tsufa), rigakafin yaduwar cututtukan zuciya da ƙwaƙwalwar ƙwayar jini, rigakafin thromboembolism bayan tiyata jijiyoyin bugun zuciya (jijiyoyin zuciya jijiya grafting, percutaneous transluminal na jijiyoyin zuciya angioplasty), m angina pectoris.

Sakawa lokacin

Ana shan maganin a baki, 1-2 awanni bayan cin abinci, 1 lokaci / rana. Allunan ya kamata a hadiye su da ruwa. Idan ana so, kwamfutar hannu za'a iya karye cikin rabi, chewed ko pre-ground.

An yi nufin amfani da miyagun ƙwayoyi don tsawan amfani. Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Don rigakafin farko na cututtukan zuciya kamar su thrombosis da rauni na zuciya a gaban abubuwan haɗari (alal misali, ciwon sukari mellitus, hyperlipidemia, hauhawar jijiyoyin jini, kiba, shan sigari, tsufa), 1 shafin. shiri wanda ya ƙunshi Acetylsalicylic acid a cikin kashi 150 na MG a ranar farko, to 1 shafin. shiri mai dauke da Acetylsalicylic acid a cikin kashi 75 na MG 1 lokaci / rana.

Don rigakafin yaduwa na dawowa daga myocardial infarction da jini na jini, guda 1. shiri mai dauke da Acetylsalicylic acid a cikin kashi 75-150 MG 1 lokaci / rana.

Don rigakafin thromboembolism bayan abubuwan tiyata a kan tasoshin (jijiyoyin jijiyoyin jini jiyya grafting, percutaneous transluminal na jijiya angioplasty), 1 shafin. shiri mai dauke da Acetylsalicylic acid a cikin kashi 75-150 MG 1 lokaci / rana.

Tare da angina m, 1 shafin. shiri mai dauke da Acetylsalicylic acid a cikin kashi 75-150 MG 1 lokaci / rana.

Idan ka rasa kashi ɗaya ko fiye na miyagun ƙwayoyi, dole ne ku ɗauki kashi ɗin da aka ɓace na ƙwayar da zaran mai haƙuri ya tuna da wannan. Don gujewa ninkawa kashi, bai kamata ku ɗauki kwamfutar da aka rasa ba idan lokacin shan magani na gaba yana gabatowa.

Peculiarities na aikin da miyagun ƙwayoyi a farkon kashi ko karbo daga cikin miyagun ƙwayoyi ba a lura.

Side sakamako

Gabaɗaya, shirye-shiryen da suka ƙunshi wannan haɗin an yarda dasu sosai.

Daga tsarin mai juyayi: sau da yawa - ciwon kai, rashin bacci, da wuya - tsananin farin ciki, bacci, da wuya - tinnitus, maganin zubar jini a cikin mahaifa.

Daga tsarin cutar haemopoietic: sau da yawa - yawan zubar jini, da wuya - anaemia, da wuya - aplastic anemia, hypoprothrombinemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, agranulocytosis. Akwai rahoto game da lokuta na hemolysis da haemolytic anemia a cikin marasa lafiya da raunin glucose-6-phosphate mai rauni mai yawa.

Daga tsarin numfashi: sau da yawa - bronchospasm.

Daga tsarin narkewa: sau da yawa - ƙwannafi, sau da yawa - tashin zuciya, amai, infrequently - jin zafi a cikin ciki, ulcers na mucous membrane na ciki da duodenum, na jini na ciki, da wuya - perforation na ciki na ciki ko duodenal miki, ƙara yawan aiki na hanta enzymes , da wuya - stomatitis, esophagitis, cututtukan erosive na babba na ciki (ciki har da tsauraran), colitis, ciwon hanji mai narkewa.

Allergic halayen: akai-akai - urticaria, Quincke ta edema, fatar fata, itching, rhinitis, kumburi da hanci, da wuya sosai - anaphylactic tura, cardiorespiratory tashin hankali cuta.

Sauran: da ƙarancin aiki - aiki bahaushe keɓaɓɓiyar aiki.