Magungunan Aspinat: umarnin don amfani

Magungunan suna da antipyretic, sakamako na analgesic.

Hanyar aikin Aspinat ta samo asali ne daga hana ayyukan cyclooxygenase 1 da enzymes 2, a ƙarƙashin ikon da yake haɗuwa da aikin prostaglandins (saboda ciwo mai raɗaɗi da kumburi a fagen aikin kumburi).

Tare da raguwa a cikin matakin prostaglandins a cikin sashi na thermoregulation a cikin kwakwalwa, gumi yana ƙaruwa kuma ƙwayar katako na gudana, wanda a sakamakon hakan ya samar antipyretic sakamako. Tasirin analgesic shine saboda tsakiya da na waje na maganin.

Acetylsalicylic acid yana hana aikin toshe enzyme na A2 a cikin ƙwayoyin jini, platelet, wanda ke rage ƙwayoyin thrombosis, adon jikin platelet da haɗinsu. Kai sakamako na antitinlet yaci gaba har sati guda bayan an sha magani daya. An lura cewa wannan tasiri yafi magana a cikin maza.

A cikin jiyya tare da acetylsalicylic acid, haɗarin haɓaka nau'in rashin daidaituwa na angina pectoris, ƙwararraki na myocardial yana raguwa, kuma yawan mace-mace daga cututtukan cututtukan zuciya.

Ana amfani da maganin Aspinat yadda ya kamata don rigakafin cutar sikari da sakandare na lalata ƙananan ƙwayar cuta, musamman a cikin maza fiye da shekaru 40.

Dailyara na yau da kullun na 6 MG yana ƙara yawan lokacin prothrombin kuma yana hana aiki prothrombin a cikin hanta hanta. Yana da mahimmanci a la'akari da cewa yayin shan acetylsalicylic acid, haɗarin zub da jini da sauransu rikicewar basur lokacin da bayan tiyata.

Aspinate yana rage yawan ƙwayar bitamin K-dogara da coagulation abubuwan 2, 7, 9 da 10. Magungunan yana haɓaka aikin fibrinolytic na ƙwayar jini, yana motsa tsarin motsa jiki uric acid daga jiki a cikin adadi kaɗan (saboda lalacewar reabsorption a cikin tubules na tsarin na koda).

Tare da toshewar cyclooxygenase-1 a cikin mucosa na ciki, ayyukan gastroprotective (kariya) prostaglandins yana raguwa, wanda zai haifar da cutar bango na ciki da haɓakar zub da jini.

Leastarancin fushi mai ban haushi a cikin mucosa na ciki ana aiki da shi ta fuskoki na musamman na acetylsalicylic acid, nau'in abinci mai narkewa da kuma sashi, wanda ya haɗa da abubuwan ɓoye.

Sauran shirye-shiryen Acetylsalicylic acid

Fom ɗin saki

Allunan (Aspinat, Aspinat Cardio, Aspinat Plus, Aspinat 300), allunan ƙwayoyin cuta (Aspinat, Aspinat C).

Aspinat: acetylsalicylic acid (100 MG ko 500 MG).

Aspinat Cardio: acetylsalicylic acid (50 MG ko 100 MG), tsoffin kaya: MCC, sitaci 1500, aerosil (silloon silicon dioxide), stearic acid, mai shigar da kayan ciki: ACRYL-IZ (copolymer na methaclates acid tare da ethyl acrylate 1: 1, titanium dioxide, talc, triethyl citrate, anhydrous colloidal silicon oxide, sodium bicarbonate, sodium lauryl sulfate), copovidone, hydroxypropyl cellulose (Klucel).

Aspen 300: acetylsalicylic acid (300 mg), shafi na shigar ido.

Aspinat Plus: acetylsalicylic acid (500 MG), maganin kafeyin (50 mg).

Aspinat S: acetylsalicylic acid (400 MG), ascorbic acid (240 mg).

Aspinat:

• Allunan 10 a cikin fakitin fakitin bezjacheykovoy, 1 ko 2 fakitoci a cikin kwali,
• 10 ko guda 20. a cikin tukunyar polymer a cikin wani kwali,
• Allunan 10 a fakitin bakin, 1 ko 2 fakitoci a cikin kwali,
• Allunan 12 na ƙwayoyin cuta a cikin akwati na polymer a cikin wani kwali.

Aspinat Cardio:

• 10 inji mai kwakwalwa a cikin fakiti, ba 1, 2, 3, 5, 10 fakitoci a cikin kwali,
• 10, 20, 30, 50 ko 100 inji mai kwakwalwa. a cikin tukunyar polymer a cikin wani kwali.

Aspen 300:

• 10 inji mai kwakwalwa a fakitin kwanon bezjacheyakovoy, fakitoci 1, 2, 3, 5 ko 10 a cikin kwali,
• 10, 20, 30, 50 ko 100 inji mai kwakwalwa. a cikin tukunyar polymer a cikin wani kwali,
• 10 inji mai kwakwalwa a cikin fakiti mai bakin ciki, fakitoci 1, 2 ko 10 a cikin kwali.

Aspinat Plus:

• 10 inji mai kwakwalwa a cikin fakitoci, ko bakin ciki 1, 2, 3 ko 5 a cikin kwali,
• 10, 12, 15, 16, 20 ko 30 inji mai kwakwalwa. a cikin tukunyar polymer a cikin wani kwali.

Aspinat S: 10 inji mai kwakwalwa. A cikin akwatin polymer a cikin fakitin kwali.

Aikin magunguna

Amfanin mai narkewa na magani idan aka kwatanta da acetylsalicylic acid na gargajiya a cikin allunan shine mafi cikakkiyar cikakke kuma mai saurin ɗaukar abu mai aiki da kuma haƙurin haƙuri.

• Matsakaici mai sauƙi ko mai laushi a cikin tsofaffi na asali daban-daban: ciwon kai (ciki har da waɗanda ke da alaƙa da maganin hana shan barasa), ciwon hakori, ciwon mara, neuralgia, radicular radicular syndrome, tsoka da ciwon haɗin gwiwa, jin zafi yayin haila.
• Temperatureara yawan zafin jiki a cikin sanyi da sauran cututtukan da ke kamuwa da kumburi (a cikin tsofaffi da yara kanana shekaru 15).

Aspinat Cardio:

• Yin rigakafin raunin myocardial infarction a gaban abubuwan haɗari (misali cutar sankarar bargo, hauhawar jini, hauhawar ciki, shan sigari, tsufa, shan sigari, tsufa),
• m angina,
• rigakafin bugun jini (gami da cikin marassa lafiya da cututtukan cututtukan zuciya),,
• rigakafin hadarin narkar da cutar sankara,
• rigakafin thromboembolism bayan aiki da kuma tashin zuciya na jijiyoyin jini (misali, na jijiya mai jijiya kewayewa grafting, carotid artery endarterectomy, arteriovenous kewaye kewaye da grafting, carotid artery angioplasty),
• rigakafin zurfin jijiya mara nauyi da kuma thromboembolism na huhu da kuma rassanta (alal misali, tare da tsawan lokaci na hana haihuwa sakamakon babban aikin tiyata).

Contraindications

• Hypersensitivity ga ASA, tsoffin magunguna da sauran NSAIDs,
• erosive da ulcerative raunuka na gastrointestinal fili, jini na ciki,
• basur na jini,
• bronchial fuka daga shan salicylates da NSAIDs, da Fernand Widal triad (hade da fuka-fuka, maɓallin hanci sau da yawa, sinadaran paranasal da rashin haƙuri ga ASA),
• hade tare da methotrexate a kashi na 15 MG a mako daya ko sama da haka,
• na koda na hepatic rashin nasara,
• ciki (I and III trimester),
• lactation
• shekaru zuwa shekaru 18.

Tare da kulawa:

• gout
• hawan jini
• tarihin cututtukan cututtukan hanji ko na jini, hanji da gazawar hanji, tarin fuka, cututtukan hanji, zazzabi, ciwan hanci, rashin lafiyar mahaifa ga wasu kwayoyi,
• Kwana uku na ciki,
• haɗuwa tare da methotrexate a cikin kashi na ƙasa da 15 MG a mako,
• rashi na bitamin K da kuma glucose-6-phosphate dehydrogenase.

Sashi da gudanarwa

A ciki, shan ruwa mai yawa. Allunan Effervescent dole ne a narkar da su a cikin 100-200 MG na ruwan zãfi a zazzabi a ɗakin.

Lokaci da jadawalin kudin likita yana ƙaddara ne ta hanyar halartar likitan mata, tunda anan ne komai ya dogara da shekaru da yanayin haƙuri.

Tare da ciwo mai zafi, zaku iya ɗaukar 400-800 mg na acetylsalicylic acid sau 2-3 a rana (amma ba fiye da 6 g kowace rana). A matsayin wakilin antiplatelet, ana amfani da ƙananan allurai - 50, 100, 300 MG na kayan aiki. Don zazzabi, ana bada shawara don ɗaukar 0.5-1 g na acetylsalicylic acid kowace rana (idan ya cancanta, ana iya ƙara yawan zuwa 3 g). Tsawon lokacin jiyya kada ya wuce kwanaki 14.

Aspinat Cardio:

An yi nufin amfani da miyagun ƙwayoyi don tsawan amfani. Tsawan likitan ne zai tantance tsawon lokacin da likitan yake.

• Yin rigakafi a lokuta da ake zargi da ƙwayar myocardial infarction shine 100-200 mg / rana (dole ne a ƙware kwamfutar hannu ta farko don ɗaukar sauri).
• Yin rigakafin raunin myocardial na farko a gaban abubuwan haɗari - 100 MG / rana.
• Yin rigakafin infarction na myocardial na maimaitawa, angina mai tsayayye, rigakafin bugun jini da hadarin cerebrovascular, hana rigakafin thromboembolic bayan tiyata ko karatu mai ban mama - 100 mg / day.
• Yin rigakafin thrombosis mai zurfi da thromboembolism na huhu da kuma rassanta shine 100-200 mg / rana.

Side sakamako

• Allergic halayen: urticaria, Quincke ta edema.
• Daga tsarin rigakafi: halayen anaphylactic.
• Daga jijiyoyin ciki: tashin zuciya, ƙwannafi, amai, jin zafi a ciki, kumburi da hancin ƙwayar ciki da na duodenum, ciki har da perforated, na ciki na jini, ta ƙara aiki na enzymes hanta.
• Daga tsarin numfashi: bronchospasm.
• Daga tsarin hawan jini: haɓakar zub da jini, anemia (da wuya).
• Daga gefen tsarin juyayi na tsakiya: dizziness, tinnitus.

Yawan abin sama da ya kamata

Ya kamata ku mai da hankali game da maye a cikin tsofaffi kuma musamman a cikin yara ƙanana (maganin warkewa ko yawan maye na haɗari, yawancin lokuta ana samun su a cikin ƙananan yara), wanda na iya haifar da mutuwa.

Bayyanar cututtuka na yawan hauhawar jini: tashin zuciya, amai, tinnitus, jin rashi, farin ciki, rikicewa.

Jiyya: raguwar kashi.

Verearnawar Cutar Adadin Cutar: zazzabi, hauhawar jini, ketoacidosis, alkalanka na numfashi, coma, cututtukan zuciya da gazawar numfashi, hauhawar jini.

Jiyya: Gaggawa asibiti nan da nan a cikin rukunin musamman don maganin gaggawa - lavage na ciki, ƙuduri na ma'aunin acid-base, alkaline da tilasta alkaline diuresis, hemodialysis, gudanar da mafita, gudanar da carbon da ke motsa jiki, maganin cututtukan cuta.

Lokacin aiwatar da alkaline diuresis, ya zama dole don cimma ƙimar pH tsakanin 7.5 zuwa 8. Ya kamata a yi aƙidar alkaline diuresis lokacin da yaduwar salicylates a cikin ƙwayar cuta ya fi 500 mg / l (3.6 mmol / l) a cikin manya da 300 mg / l (2, 2 mmol / l) - a cikin yara.

Hulɗa da ƙwayoyi

Tare da yin amfani da ASA lokaci guda yana inganta aikin waɗannan kwayoyi masu zuwa:

• methotrexate - saboda raguwar karɓar keɓaɓɓe da ƙaura daga sadarwa tare da sunadarai,
• heparin da magungunan anticoagulants marasa daidaituwa - saboda aiki raunin platelet da yaduwar cututtukan cututtukan karkara daga sadarwa tare da sunadarai,
• maganin thrombolytic da antiplatelet (ticlopidine),
• digoxin - saboda raguwa a cikin aikin ta na din din din,
• wakilan hypoglycemic (insulin da abubuwan da ake samowa na sulfonylurea) - saboda abubuwan da ake amfani da su na asalin cutar ASA da kanta a cikin manyan allurai da kuma kwararar abubuwanda suka samo asali daga sadarwa tare da sunadarai,
• valproic acid - saboda ƙaurarsa daga sadarwa tare da sunadarai.

Ana lura da sakamako mai ƙari yayin shan ASA tare da barasa.

ASA tana raunana tasirin magungunan uricosuric (benzbromarone) saboda gushewar tubular gasa ta uric acid.

Ta hanyar inganta kawar da salicylates, tsarin corticosteroids na rushe tasirin su.

Haihuwa da lactation

Amfani da manyan allurai na salicylates a farkon farkon haihuwa yana da alaƙa da haɓakar kumburin haɓakar tayi (raunin palate, raunin zuciya).

A cikin watanni biyu na ciki, ana iya ba da umarnin yin amfani da sutturar salula tare da cikakken ƙima na hadarin da fa'ida.

A cikin kashi na karshe na ciki, salicylates a cikin babban kashi (fiye da 300 MG / rana) yana haifar da hanawar aiki, rufewar hanji da yatsun mahaifa a cikin tayin, ƙara yawan zubar jini a cikin mahaifiya da tayin, da kuma gudanarwa kai tsaye kafin haihuwa na iya haifar da zubar jini cikin mahaifa, musamman a cikin jarirai.

Nadin salicylates a cikin ƙarshen sati na ƙarshe na ciki ya haɗu.

Salicylates da metabolites ɗin su a cikin adadi kaɗan sun shiga cikin madara. Yawan cin abinci mai gishiri a lokacin shayarwa baya tare da haɓakar halayen da ake samu a cikin yaro kuma baya buƙatar daina shayarwa. Koyaya, tare da tsawan amfani da miyagun ƙwayoyi ko alƙawarin babban kashi, ya kamata a dakatar da shayar da jarirai nan da nan.

Umarni na musamman

Ya kamata a yi amfani da Aspen kawai bayan alƙawarin likita.

Magungunan zai iya ba da gudummawa ga zub da jini, tare da ƙara tsawon lokacin haila. Acetylsalicylic acid na kara hadarin zub da jini idan anyi tiyata.

Ba a yin amfani da aspinate a cikin ƙuruciya saboda haɗarin cutar Reye.

Ba'a lura da tasiri kan damar tuƙin mota / inji.

Alamu don amfani

Aspen an wajabta don tsayawa cutar febrile, wanda ke haɗuwa da cututtukan da yawa masu kamuwa da cuta da kumburi.

A halin yanzu, acetylsalicylic acid ba a amfani dashi don bi da shi pericarditisrheumatoid amosanin gabbai rheumatic chorea, rheumatism da rashin lafiyan kamuwa da cuta myocarditis.

Umarnin don yin amfani da Aspinat yana ba da shawarar sarrafa magani don cimma sakamako na antiplatelet (a ƙarar har zuwa 300 MG kowace rana) ga marasa lafiya da angina mai rashin ƙarfi, cututtukan zuciya na zuciya, maimaita rauni na myocardial, bugun jini na ischemic, tare da bawuloli masu taushi, tare da sakawa mai ƙarfi, bayan coronary balloon angioplasty.

Ana amfani da miyagun ƙwayoyi don sauƙaƙa jin zafi na asali daban-daban: lumbago, arthralgia, ciwon kai (ciki har da raunin migraine wanda ya haifar da alamu na janyewa), neuralgia, ciwon hakori, algomenorrhea, kirji radicular syndrome, ciwon tsoka.

A cikin maganin rigakafin ƙwaƙwalwar ƙwaƙwalwa da rigakafi na asibiti, An bada shawarar yin amfani da Aspinat don ƙara yawan allurai don haɓaka haƙuri (juriya) ga magungunan anti-mai kumburi marasa ƙarfi a cikin marasa lafiya da ke fama da "Asfirin triad" da "Asfirin fuka".

Side effects

Jiyya na iya haifar da tashin zuciya, zawo, Reye ciwo (saurin haifar da gazawar hanta, matsanancin ƙarancin hanta da encephalopathy), ciwancin abinci, rashin amsar da ake samu a jiki irin na bronchospasm, fatar jiki da angioedema.

Acetylsalicylic acid na iya haifar da “aspirin triad” da “aspirin ashma” saboda kirkirar hanyar hapten.

Dogon lokacin magani yana tare da ciwon kai, raunin gani, yashwa da raunuka na tsarin narkewa, tinnitus, amai, amai, nephrotic syndromepapillary necrosis, bronchospasm, tsinkaye yanayin binciken yanayin, hypocoagulation, interstitial nephritis, hypercalcemia, prerenal azotemia, kumburi, ƙara matakan hanta enzymes, ƙara alamun rashin lafiyar zuciya, maganin ciwon hanji.

Aspinat, umarnin don amfani (Hanyar da sashi)

Allunan Aspinat Allunan ana bada shawara don narkar da su cikin karamin ruwa kafin amfani: 2-3-8 sau a rana akan 400-800 MG (amma ba fiye da gram 6).

Acetylsalicylic acid a cikin kashi na 50-70-100-300-325 mg ana amfani dashi don cimma sakamako na antitinlet, a cikin kashi fiye da 325 MG - don cimma analgesic da anti-mai kumburi sakamako.

A cikin tsananin rheumatism sanya 100 MG a 1 kg a rana don allurai 5-6.

Tare da matsanancin zafi da febrile syndromes An wajabta wa manya kai 0.5-1 a rana (don allurai 3).

Tsawon lokacin aikin Aspinat bai kamata ya wuce kwanaki 14 ba.

Dole ne a narke nau'ikan maganin da ke cikin maganin a cikin 100-200 ml na ruwa kafin shigowa, zai fi dacewa bayan cin abinci.

Tsawan lokacin jiyya na iya bambanta daga kashi ɗaya zuwa watanni da yawa.

Ga marasa lafiya da suka sha wahala infarction na myocardial, an wajabta maganin don rigakafin sakandare a kashi 40-325 MG kowace rana (matsakaicin sashi shine 160 mg).

Inganta halayen rheological jini ana samun su ta amfani da 0.15-0.25 grams na acetylsalicylic acid kowace rana (an tsara warkarwa na tsawon watanni).

A kashi na 300-325 MG kowace rana, miyagun ƙwayoyi suna hana haɗarin platelet na sel jini.

Athromboembolism Asalin ma'adanai, tare da haɓakar haɗarin cerebrovascular a cikin maza, ana tsara 325 MG kowace rana (adadin ƙwayar yana raguwa zuwa 1 gram a kowace rana).

Ana samun rigakafin farfadowa ta hanyar shan 125-300 MG kowace rana.

Don rigakafin bazuwa da ƙwayar aortic shunt da thrombosis, ana ba da shawarar cewa ana gudanar da maganin ta hanyar bututu na ciki na musamman da aka sanya cikin ciki a kan kwayar 325 a kowane 7 hours. Furtherarin gaba, kulawa da baka na acetylsalicylic acid sau uku a rana a kashi na 325 mg ana bada shawarar (mafi yawan lokuta, ana yin maganin dipyridamole har tsawon mako guda).

Haɗa kai

Aspinate yana ƙara yawan guba da heparin, sulfonamides, jami'ai masu ƙarfi, ƙwaƙwalwar narcotic, madarar ruwa, Co-trimoxazole, kai tsaye anticoagulants, kashiwa, tarawar inzali platelet, thrombolytics.

Magunguna yana iya rage tasirin magungunan diuretic (furosemide, Veroshpiron), magungunan antihypertensive.

Hadarin da ke haifar da zubar da jijiyoyin jini yana ƙaruwa sosai yayin shan magungunan ethanol, glucocorticosteroids.

Hematotoxicity na Aspen yana ƙaruwa tare da magani tare da kwayoyi na myelotoxic.

Magungunan Antacid worsen sha da acetylsalicylic acid.

Yadda ake amfani: sashi da hanya na jiyya

Allunan Allunan: a ciki, a baya an narkar da shi a cikin karamin ruwa, 400-800 MG sau 2-3 a rana (babu fiye da 6 g). A cikin tsananin rheumatism - 100 MG / kg / rana a cikin allurai 5-6.

Allunan da suke dauke da ASA a allurai sama da 325 mg (400-500 mg) an tsara su ne don amfani azaman analgesic da anti-mai kumburi, a cikin allurai na 50-75-100-300-325 mg a cikin manya, akasari azaman maganin antiplatelet.

A ciki, tare da febrile da ciwo na ciwo, manya - 0.5-1 g / day (har zuwa 3 g), sun kasu kashi uku. Tsawon lokacin jiyya kada ya wuce makonni 2.

Allunan kwayoyi masu kyau sun narke a cikin 100-200 ml na ruwa kuma an sha su a baki, bayan abinci, kashi ɗaya - 0.25-1 g, ana ɗauka sau 3-4 a rana. Tsawon lokacin jiyya - daga kashi ɗaya zuwa karatun watanni da yawa.

Don haɓaka ƙirar rheological na jini - 0.15-0.25 g / rana don watanni da yawa.

Tare da infarction na myocardial, har ma da rigakafin sakandare a cikin marasa lafiya bayan infarction na myocardial, 40-325 mg sau ɗaya a rana (yawanci 160 mg). A matsayin mai hana agarin platelet - 300-325 mg / rana na tsawon lokaci. Tare da rikicewar ƙwayar cerebrovascular mai ƙarfi a cikin maza, thromboembolism na cerebral - 325 mg / rana tare da haɓaka hankali zuwa mafi girman 1 g / rana, don rigakafin sake dawowa - 125-300 mg / rana. Don rigakafin thrombosis ko occlusion na aortic shunt, 325 mg kowane 7 hours ta hanyar bututun ciki na ciki, to 325 mg ta baki sau 3 a rana (yawanci a hade tare da dipyridamole, wanda aka soke bayan mako guda, ci gaba da tsawaita jiyya tare da ASA).

Tare da yin amfani da rheumatism da aka tsara (a halin yanzu ba a umurce shi ba) a cikin kashi na 5-8 g na manya da 100-125 mg / kg ga matasa (shekaru 15-18), yawan amfani shine sau 4-5 a rana. Bayan makonni 1-2 na jiyya, an rage yara zuwa 60-70 mg / kg / rana, ana ci gaba da kula da manya a cikin kashi ɗaya, tsawon lokacin magani ya kasance har zuwa makonni 6. Canza wuri ana aiwatar da shi a hankali tsakanin makonni 1-2.