Magungunan Glimepiride don rage sukari a cikin ciwon sukari

Glimepiride (a cikin girke-girken Latin - Glimepiride) - Wannan magani ne wanda ba'a manta dashi yau ba. Daga cikin dukkanin magungunan maganin antidi da ke wakiltar aji na magungunan sulfonylurea, wannan magani ne mai dacewa sosai. Lokacin da kwayoyin sun fara bayyana a cibiyar sadarwar kantin magani, sun kasance ɗayan magungunan mashahuri. Amma bayan gano wani sabon aji na kwayoyi (incretins), sai suka fara manta undeservedly.

Har ila yau, maganin yana da yiwuwar ƙarin cututtukan cututtukan ƙwayar cuta: ƙara haɓakar jijiyoyin jiki zuwa insulin na rayuwa, rage samar da glucose a cikin hanta, hana ƙwanƙwasa jini, da rage matakin radicals.

Form sashi

Kamfanin masana'antar cikin gida PHARMSTANDART yana samar da Glimepiride a cikin nau'ikan allunan kabbara guda 4:

• Haske mai ruwan hoda - 1 MG,
• Haske kore mai haske - 2 MG,
• Haske mai rawaya - 3 MG,
• Haske mai launin shuɗi - 4 MG.

An kwantar da capsules a cikin murhun alummuka na inji mai kwakwalwa guda 10., An sanya faranti a cikin kunshin takarda. Adana magungunan a cikin akwatina na asali a zazzabi na ɗakuna sama da shekaru 3. Ga Glimepiride, farashin a kantin magunguna na kan layi ya kasance daga 153 rubles. har zuwa 355 rub. dangane da sashi. Kasuwan magani shine magani.

Glimepiride - analogues da kwatanci

Magungunan asali, na farko, mafi yawan karatu, shine Amaril daga kamfanin Sanofi Aventis. Duk sauran magunguna, gami da glimepiride, analogues ne, kamfanonin magunguna suna samar da su bisa ga patent. Daga cikin shahararrun:

• Glimepiride (Russia),
• Diamerid (Russia),
• Diapirid (Ukraine),
• Glimepirid Teva (Croatia),
• Glemaz (Argentina),
• Glianov (Jordan),
• Glibetik (Poland),
• Amaril M (Korea),
• Glairi (Indiya).

Abun da ke cikin magani Glimepiride

Glimepiride wakili ne na maganin antidiabetic mai dauke da karfin rashin karfin jini. Magungunan yana cikin rukunin sulfonamides, abubuwan asalin urea.

Babban kayan aiki na maganin shine glimepiride. A cikin kwamfutar hannu guda, nauyinsa shine 1 zuwa 4 MG. An inganta abu mai aiki tare da abubuwan taimako: sitaci sitaci, povidone, polysorbate, microcrystalline cellulose, lactose, magnesium stearate, indigo aluminum varnish.

Pharmacology

Glimepiride magani ne na antidiabetic daga ƙungiyar sulfonylurea wanda ke aiki idan an sha shi ta baki. An tsara shi don sarrafa nau'in ciwon sukari na 2. Hanyar aikin miyagun ƙwayoyi ya dogara ne akan ƙaruwar ƙwayoyin-responsible-mai alhakin samar da insulin kwayoyin halitta. Magungunan suna haɗuwa da furotin membrane na waɗannan sel cikin sauri.

Kamar duk magunguna a cikin wannan rukunin, ƙwayar tana ƙara ƙarfin jiɓin kyallen takarda zuwa haɓakar glucose. Yana da magani da kuma tasirin karin magana. Samun insulin a ƙarƙashin rinjayar miyagun ƙwayoyi yana faruwa ne saboda ingantacciyar damar zuwa tashoshin calcium: haɓakawa da yawaitar ƙwayar alli yana inganta sakin insulin.

Daga cikin illolin da ke tattare da cutarwar, ana iya samun raguwar juriyar sel ga kwayar halitta da raguwar yadda ake amfani da ita a hanta. A cikin tsokoki da kitse na jiki, glucose yana ƙonewa tare da taimakon jigilar furotin, aikin da ke ƙaruwa sosai bayan ɗaukar magani.

Pharmacokinetics

A bioavailability na glimepiride ne 100%. Daidaici shan abinci mai gina jiki yana rage jinkirin sha kadan. Ana lura da mafi girman abubuwan plasma 2.5 sa'o'i bayan an karɓi magani a cikin narkewa. Distributionarancin magunguna yana ƙasa da ƙasa (8.8 L), yana ɗaure wa furotin magani gwargwadon iko (99%), ɗaukar magunguna shine 48 ml / min.

Tare da sake yin amfani da allurar allura, matsakaicin rabin rayuwar shine awowi 5-8. Tare da karuwa a cikin maganin warkewa, wannan lokacin yana ƙaruwa. An cire metabolabolites ta halitta: 58% na kashi ɗaya wanda aka nuna ta hanyar isotope na rediyo wanda aka samu a cikin fitsari kuma 35% a cikin feces. Rabin rayuwar samfuran lalata ne sa'o'i 3-6.

Babu bambance-bambance na asali a cikin kantin magani na glimepiride a cikin masu ciwon sukari na matasa ko balagagge, mace ko namiji. A cikin masu ciwon sukari tare da ƙarancin keɓantar da ƙwaƙwalwar ƙwayar cuta, babu wani haɗarin haɗuwa da miyagun ƙwayoyi. Sigogi na pharmacokinetic a cikin marasa lafiya 5 bayan cholecystectomy sun yi kama da waɗanda ke cikin masu ciwon sukari a cikin wannan.

A cikin matasa 26 da ke shekaru 12-17, da kuma yara 4 zuwa 10 na shekara 10, marassa lafiya masu fama da ciwon sukari na 2, kashi ɗaya na ƙananan (1 MG) na maganin ya nuna sakamakon kama da na manya.

Wanda ba a nuna glimepiride ba

Magungunan ba su dace da masu ciwon sukari tare da nau'in cutar ta 1 ba, ba a amfani da su don cutar ketoacidosis, coma da precoma, da kuma mummunan koda da cututtukan hanta.

Kamar kowane magani, ba a sanya maganin glimepiride don masu ciwon sukari tare da babban ji game da abubuwan da ke cikin tsari, har ma da sauran magunguna na sulfonylamide.

Glimepiride yana contraindicated a cikin ciki da lactation.

Yadda ake amfani da Glimepiride daidai

Don tabbatar da kulawar glycemic 100%, maganin shan magani bai isa ba.

Tsarin tabbatacce na ɗaukar nauyin tsoka a cikin ciwon sukari na nau'in haske na 2 da na tsakiya na iya zama kamar haka:

• Darasi mai ƙarfi - 2-3 p / Makon.,
• Ingantaccen tafiya - 3 p / Makon.,
• Waha, keke, tennis ko rawa,
• Tafiya, tafiya mai natsuwa - kullun.

Idan irin wannan hadaddun bai dace ba, zaku iya yin aikin motsa jiki a kowace rana. A cikin wurin zama, mai ciwon sukari na iya zama ba tare da hutu ba na tsawon minti 30.

An zaɓi mafi kyawun maganin warkewa ta likita, yin la'akari da matakin cutar, rikice-rikice masu rikice-rikice, yanayin gaba ɗaya, shekarun mai haƙuri, yanayin jikinsa ga miyagun ƙwayoyi.

Umarnin Glimepiride don amfani yana bada shawarar yin amfani da 1 MG / rana. (a farawa). Tare da yawaita na makonni 1-2, lokacin da ya yiwu a kimanta sakamakon, ana iya sanya shi kyauta idan tsarin aikin magani na baya bai wadatar ba. Ka'idar ta fi 4 MG / rana. amfani a lokuta na musamman. Matsakaicin adadin magani shine har zuwa 6 MG / rana.

Idan matsakaicin ƙwayar metformin ba ta ba da iko na glycemic 100%, ana iya ɗaukar Glimepiride azaman maganin tallafawa a lokaci guda, ana haɗa shi daidai da wannan ƙwayar, har ma da magungunan haɗin gwiwa tare da waɗannan abubuwan haɗin gwiwar guda biyu da aka saki. Cikakken magani yana farawa da mafi ƙarancin ƙwayar glimepiride (1 g), saka idanu na yau da kullum na alamomin glucometer zai taimaka wajen daidaita daidaitaccen. Duk canje-canje zuwa algorithm ana yin su ne kawai a ƙarƙashin kulawa na likita.

Wataƙila haɗuwa da glimepiride kuma tare da shirye-shiryen insulin. Sashi na allunan, a wannan yanayin, dole ne ya zama ɗan ƙaramin abu. Dangane da sakamakon gwaje-gwajen, kowane mako biyu ana amfani da maganin.

Yawancin lokaci, shan maganin ba shi da aure. Hada shi da ingantaccen karin kumallo ko abinci a bayansa, idan karin kumallo a cikin mai sukari alama ce.

Zai fi kyau a ɗauki kwaya 'yan mintoci kaɗan kafin cin abinci, saboda yana ɗaukar lokaci don aiwatarwa. Idan baku bata lokacin daukar Glimepiride ba, yakamata a sha magani a farkon damar, ba tare da canza sashi ba.

Idan mafi ƙarancin ƙwayar glimepiride yana haifar da bayyanar cututtuka na hypoglycemia, an soke maganin, tunda ya isa ga mai haƙuri don sarrafa sukarinsa tare da abinci mai dacewa, yanayi mai kyau, yarda da bacci da hutawa, isasshen aikin jiki.

Lokacin da aka sami cikakken iko na ciwon sukari, juriya na hormone na iya raguwa, wanda ke nufin cewa a tsawon lokaci, buƙatar magani zai ragu. Hakanan wajibi ne don sake duba kashi tare da asarar nauyi kwatsam, canji a yanayin aikin motsa jiki, yaduwar yanayin damuwa da sauran abubuwan da ke haifar da rikicewar glycemic.

Yiwuwar sauyawa daga wasu wakilai masu maganin antidi masu guba zuwa glimepiride

Lokacin juyawa daga zaɓin magani na madadin don ciwon sukari na 2 tare da wakilai na baka, ana yin la'akari da rabin rayuwar magungunan da suka gabata. Idan maganin yana da tsayi tsawon lokaci (kamar chlorpropamide), dole a kiyaye hutu na kwanaki da yawa kafin canzawa zuwa glimepiride. Wannan zai rage damar haɓakar haɓakawar jini sakamakon tasirin mahaɗin 2. Lokacin maye gurbin kwayoyi, ana bada shawarar farawa a mafi ƙarancin 1 mg / rana. Ana aiwatar da taken a ƙarƙashin yanayi iri ɗaya.

Sauyawa insulin na Glimepiride a cikin masu ciwon sukari tare da nau'in cuta na 2 ana yin shi a cikin matsanancin yanayi kuma a karkashin kulawa na likita koyaushe.

Side effects

Don maganin glimepiride, da sauran magungunan sulfa, an tabbatar da ingantaccen shaidar tabbatar da ingancin su. Nazarin asibiti ya kuma bincika amincin su. Dangane da shawarwarin WHO, ana tantance hadarin bunkasa tasirin abin da ba'a so ba akan ma'auni:

• Mafi yawan lokuta ≥ 0.1,
• Sau da yawa: daga 0.1 zuwa 0.01,
• Rakaitaccen lokaci: daga 0.01 zuwa 0.001,
• Da wuya: daga 0.001 zuwa 0.0001,
• Da wuya a sami yawan Taimako

Babban haɗarin haɗarin zubar da jini na Glimepiride shine hypoglycemia wanda zai iya kaiwa zuwa sa'o'i 72, bayan al'ada, koma-baya na yiwuwa. Alamun farko na yawan abin sama da ya kamata na iya faruwa ne kwana guda bayan sha maganin. Tare da irin wannan bayyanar cututtuka (cuta dyspeptik, ciwon kirji), wanda aka azabtar yana buƙatar kulawa a cikin asibiti. Tare da hypoglycemia, cututtukan cututtukan jijiyoyi suma suna yuwuwar: wahayi na gani da daidaituwa, rawar hannu, damuwa, matsananciyar motsa jiki, tashin zuciya

Taimako na farko idan aka samu yawan shan ruwa shine rigakafin sha daga wuce haddi ta hanyar wanke ciki. Kuna buƙatar haifar da gag reflex ta kowace hanya, sannan ku sha gawayi mai aiki ko wani adsorbent da wasu laxative (alal misali, sodium sulfate). A lokaci guda, dole ne a kira motar asibiti don asibiti mai gaggawa.

Za a shigar da wanda aka azabtar da shi tare da glucose a cikin ciki: na farko, 50 ml na maganin 50%, to - 10%. Duk lokacin da zai yiwu, kuna buƙatar bincika matakin sukari a cikin plasma. Baya ga takamaiman magani, ana amfani da Symptomatic.

Idan yaro ba da gangan ya ɗauki glimepiride, an zaɓi sashi na glucose yana la'akari da yiwuwar haɓakar ƙwararraki. Ana kimanta matakin haɗarin lokaci-lokaci tare da glucometer.

Glimepiride yayin daukar ciki

Fitowar jiki daga tsari a cikin jini yayin daukar ciki na iya haifar da mummunar cutar tayin ciki har ma da mutuwar haihuwa, kuma sigogi na glycemic a wannan batun ba su bane. Don rage haɗarin teratogenic, mace tana buƙatar kulawa da bayanin bayanan glycemic ɗinta akai-akai.

Idan mai ciki - mai ciwon sukari da nau'in cuta ta 2, an canza shi zuwa ɗan lokaci zuwa insulin. Matan da suka riga sun kasance a matakin shiryawa na yaro ya kamata su gargaɗi mahaɗan endocrinologist game da canje-canje masu zuwa don gyara tsarin kulawa.

Babu wani bayani game da illolin cutar tayin ɗan adam na glimepiride. Idan muka mai da hankali kan sakamakon binciken dabbobi masu juna biyu, ƙwayar tana da guba ta haihuwa da ke alaƙa da tasirin hypoglycemic na glimepiride.

Ba a tabbatar da ko maganin yana shiga cikin madarar mahaifiyar ba, amma magani ya shiga cikin madarar mahaifiyar a cikin beraye, saboda haka ana kuma fasa allunan a lokacin shayarwa. Tunda sauran kwayoyi na jerin maganin sulfonylomide sun shiga cikin madarar nono, haɗarin hauhawar jini a cikin jariri yana da gaske.

Babu bayanai game da amfani da miyagun ƙwayoyi ga yara masu fama da cutar sukari a ƙarƙashin shekaru 8. Don tsufa (har zuwa shekaru 17), akwai wasu shawarwari don amfani da maganin azaman maganin monotherapy. Bayanin da aka buga bai isa don amfani da miyagun ƙwayoyi ta wannan rukuni na masu ciwon sukari ba, saboda haka

Siffofin Glimepiride Jiyya

Sun sha magungunan 'yan mintoci kaɗan kafin cin abinci don maganin ya sha kuma ya fara aiki. Tare da isasshen diyya don ƙarfin maganin tare da carbohydrates, zai iya tsokani yanayi na rashin ƙarfi. Za a iya gane harin ta hanyar haɗuwa da alamomin masu zuwa: ciwon kai, ci, wolfish, dyspeptic cuta, isomnia, sabon abu farfadowa, bayyanar tashin hankali, hana hanawa, karuwar damuwa, damuwa, hangen nesa da magana, rikicewar hankali, asarar hankali da sarrafawa, ɓarkewar hanji, fainting , precom da kuma coma. Ana nuna Adrenergic counterregulation ta hanyar ƙara yawan zufa, dabino, rudewa damuwa, tashin hankali zuciya, hauhawar jini, cututtukan zuciya.

Kwarewa a cikin lura da masu ciwon sukari tare da analogues na jerin hanyoyin sulfonylomide ya nuna cewa, duk da tabbataccen tasiri na matakan dakatar da kai harin, akwai hadarin sake faruwarsa. Hanya mai rauni da tsawan lokaci, wanda a lokaci-lokaci ta saba a ƙarƙashin rinjayar sukari na yau da kullun, ya ƙunshi magani na gaggawa, gami da yanayi mai tsayi. Abubuwan da ke biyo baya suna kara haɗarin haɓakar hypoglycemic:

• Yin watsi da shawarar likita, rashin iya aiki tare,
• Abubuwan da ake buƙata na jin yunwa, abinci marasa kan gado, rashin isasshen abinci saboda yanayin rayuwar jama'a mara kyau,
• Rashin cika ka'idodin abinci mai karancin-carb,
• Rashin daidaituwa tsakanin nauyin ƙwayar tsoka da cin abinci na carbohydrate,
• Almubazzaranci, musamman tare da rashin abinci mai gina jiki,
• Renal da hepatic dysfunctions,
• Yawan ruwan sama na Glimepiride
• Decompensated endocrine pathologies da suka shafi tafiyar matakai na rayuwa (pituitary ko adrenal insufficiency, thyroid dysfunction),
• Amfani da wasu magunguna na lokaci daya

Tare da maganin ƙwayar cuta, ana buƙatar saka idanu akai-akai game da glycemia. Don kaucewa rikice-rikice, wajibi ne a riƙa yin wasu gwaje-gwaje a kai a kai:

• Checking glycated haemoglobin - 1 lokaci / watanni 3-4,
• Tattaunawa da likitan mahaifa, nephrologist, likitan zuciya, likitan zuciyar - idan ya cancanta,
• Microalbuminuria - sau 2 / shekara,
• Kimantawa na bayanan lipid + BH - 1 lokaci / shekara,
• Nazarin kafafu - 1 lokaci / watanni 3,
• HELL - 1 lokaci / wata,
• ECG - lokaci 1 / shekara,
• Nazarin gaba ɗaya - 1 lokaci / shekara.

Yana da mahimmanci a lura da aikin hanta da kuma abubuwan da ke tattare da jini, musamman rabewar platelet da leukocytes.

Idan jiki yana fuskantar matsananciyar damuwa (raunin jiki, ƙonewa, tiyata, mummunan cututtuka), maye gurbin allunan na ɗan lokaci tare da insulin zai yiwu.

Babu wani gogewa game da amfani da miyagun ƙwayoyi don lura da masu ciwon sukari tare da matsanancin hepatic, kazalika da marasa lafiyar hemodialysis. A cikin dysfunctions na koda ko hepatic, ana canza shi daga mai ciwon sukari zuwa insulin.

Glimepiride yana da lactose. Idan mai ciwon sukari yana da rashin jituwa ga kwayoyin halittar ga galactose, rashi lactase, malabsorption na galactose-glucose, ana bashi magani na maye gurbin.

Sakamakon glimepiride akan iya sarrafa abubuwa masu rikitarwa

Ba a gudanar da bincike na musamman game da glimepiride akan ikon tuka motoci ko aiki a samarwa a yankin mai haɗari ba a gudanar da shi. Amma, tunda miyagun ƙwayoyi suna da tasirin sakamako a cikin hanyar hypoglycemia, akwai haɗarin raguwa a cikin saurin halayen da tattara hankali saboda hangen nesa mai rauni da sauran alamun hypoglycemic.

Lokacin da yake rubuta magani, ya kamata a faɗakar da mai ciwon sukari game da haɗarin mummunan sakamako lokacin da ake sarrafa magunguna masu rikitarwa. Gaskiya ne gaskiya ga waɗanda galibi suna da yanayin rashin ƙarfi, da waɗanda basu iya gane alamun cutar matsala mai zuwa ba.

Sakamakon hulɗa tare da wasu magunguna

Amfani da magunguna na yau da kullun na iya haifar da mai ciwon sukari don haɓaka ƙarfin ƙwayar cuta ta glimepiride kuma ta hana kayan ta. Wasu magunguna ba su da tsaka tsaki lokacin amfani da su tare. Awararren likita ne kawai zai iya ba da cikakken ƙididdigar gwargwadon jituwa, saboda haka, lokacin ƙirƙirar tsarin magani, ya zama dole a faɗakar da endocrinologist game da duk magungunan da mai ciwon sukari ya riga ya ɗauka don magance cututtukan concomitant.

Effectarfafa tasirin hypoglycemic na Glimepiride yana tsokane amfani da phenylbutazone, azapropazone da oxyphenbutazone, insulin da maganganu na maganganu, magungunan sulfanilamides, metformin, tetracyclines, MAO inhibitors, salicylic aminocyclinolono , miconazole, fenfluramine, rashin biyayya, pentoxifylline, fibrates, tritocvalian, ACE inhibitors, fluconazole , Fluoxetine, allopurinol, simpatolitikov, cyclo, Trojan da phosphamide.

Inhibition na hypoglycemic damar glimepiride yana yiwuwa tare da haɗuwa da jiyya tare da estrogens, saluretics, diuretics, glucocorticoids, abubuwan haɓaka thyroid, abubuwan da aka samo na phenothiazine, adrenaline, chlorpromazine, mai juyayi, acid na nicotinic (musamman tare da babban amfani), laxatives (tsawaita aiki tare) , glucagon, barbiturates, rifampicin, acetosolamide.

Ana ba da tasirin da ba a iya faɗi ba ta hanyar hadaddun farke tare da β-blockers, clonidine da reserpine, da kuma yawan shan barasa.

Glimepiride yana da ikon rage ko ƙara tasiri a jikin abubuwan da aka samo na coumarin.

Nazarin Glimepiride

A cewar likitoci da marasa lafiya, glimepiride magani ne mai inganci sosai. An bayar da amincinsa cikin ƙananan allurai, yana kuma da ƙarin featuresarin fasalulluka waɗanda ba za su iya yin farin ciki ba sai dai su yi farin ciki. Amma, kamar dukkan magungunan maganin cututtukan cututtukan ƙwayar cuta, anail anail na Amiil yana da tasiri kawai idan mai ciwon sukari kansa ya taimaka masa.

• Olga Grigoryevna, Yankin Moscow. Ina shan kwamfutar hannu na Glimepiride (2 MG) kafin karin kumallo, da kuma bayan cin abinci - shima M tsawan Metforminum da safe da maraice na 1000 MG. Idan ban yi zunubi da abinci ba, to ana adana magunguna a cikin sukari. Ban san wanda ya fi girma girma ba, amma a lokutan hutu, lokacin da yake da wuya a guji liyafa da yawan cin abinci, Ina shan 3 MG na Glimepiride. An ayyana mini magani a polyclinic gwargwadon rage yawan sayan magani, shi ya sa komai ya dace da ni.
• Andrey Vitalievich, Yekaterinburg. Kimanin shekaru 3 an umurce ni da Amaril, na sha sau 4 da safe. Sannan a asibitin babu Amaril kyauta, sun maye gurbinsa da Glimepirid, jigon kuɗi. Na yi ƙoƙari in ɗauka daidai gwargwado - sukari ya yi tsalle zuwa 12 mmol / l (ya kasance bai fi 8 ba). Likita ya karu da kaso zuwa mil 6, komai ya yi kyau, amma har yanzu na sayi Amaril. Kuma sake, 4 MG kowace rana ya ishe ni. Amma tabbas zan dawo cikin tsarin analog na kyauta, saboda har yanzu ina siyan magungunan zuciya da kwayayen kwaladi. Abun tausayi ne ya soke Amaril kyauta.
• Masu warkarwa na gargajiya sunyi imani cewa nau'in ciwon sukari na 2 ba kawai cuta ba ce daga cutar rashin abinci mai gina jiki da kuma salon rayuwa, amma kuma daga rashin iya jin daɗin rayuwa, daga damuwa. Don amsar su da kyau, dole ne ku kasance mai jituwa, ana nufin soyayya.

Umarnin don amfani da allunan

Takardar sayen magani daga kwararrun masu magani shine babban yanayin da zaka iya siyan magungunan na Glimepiride. Lokacin sayen magani, al'ada ce don kulawa da bayanin da aka ayyana a cikin umarnin da aka haɗe.

Sashin magunguna da tsawon lokacin kulawa ana daukar su ne ta hanyar endocrinologist, gwargwadon matakin glycemia na mai haƙuri da kuma lafiyar sa gaba ɗaya. Lokacin shan Glimepiride, umarnin don amfani ya ƙunshi bayanin cewa yana da mahimmanci a sha 1 MG sau ɗaya a rana. Samun ingantaccen aikin magunguna, ana iya ɗaukar wannan matakan don kula da matakan sukari na yau da kullun.

Idan mafi ƙasƙanci sashi (1 mg) ba shi da tasiri, likitoci suna ba da madaidaiciya 2 MG, 3 MG ko 4 MG na miyagun ƙwayoyi kowace rana. A cikin halayen da ba a san su ba, ana iya ƙara yawan zuwa 3 mg sau biyu a rana a ƙarƙashin tsananin kulawa na likita.

Allunan dole ne a ɗauka gabaɗaya, ba a tauna shi kuma an wanke shi da ruwa. Idan kun tsallake shan magani, ba za ku iya ninka biyu ba.

Hada glimepiride tare da insulin, kashi na maganin a cikin tambaya ba ya buƙatar canzawa. An wajabta maganin insulin tare da ƙaramin kashi, a hankali yana ƙara shi. Haɗin magunguna guda biyu yana buƙatar kulawa ta musamman daga likita.

Lokacin canza tsarin kulawa, alal misali, sakamakon canzawa daga wani wakilin antidiabetic zuwa glimepiride, suna farawa da ƙananan allurai (1 mg).

Harkokin canji daga insulin faris zuwa shan Glimepiride yana yiwuwa, lokacin da mai haƙuri ya riƙe aikin asirin ƙwayoyin beta na pancreatic a cikin nau'in 2 na ciwon sukari. A karkashin kulawa na likita, marasa lafiya suna daukar 1 mg na miyagun ƙwayoyi sau ɗaya a rana.

Lokacin sayen magani na maganin antidiabetic, ya kamata ka kula da lokacin ƙarewarsa. Don glimepiride, shekaru 2 ne.

Contraindications da m halayen

Kamar kowane magani, magungunan Glimepiride contraindications da mummunan tasirin na iya zama dalilin da yasa aka haramta amfani da shi ga wasu rukunin marasa lafiya.

Tunda abun da ke ciki na allunan sun hada da abubuwanda ke haifar da rashin lafiyan jijiyoyi, daya daga cikin manyan abubuwan da ke haifar da wannan maganin na hypoglycemic shine rashin kwanciyar hankali ga wadannan abubuwan.

Ari ga haka, an hana karɓar kuɗi lokacin da:

• mai ciwon sukari ketoacidosis,
• ciwon sukari wanda yake dogaro da kansa
• ciwon sukari
• koda ko hanta,
• haihuwar ɗa
• nono.

Masu haɓaka wannan magani sun gudanar da karatun asibiti da kuma bayan-tallace na kasuwanci da yawa. Sakamakon haka, sun sami damar yin amfani da abubuwanda suka haifar, sun hada da:

Idan yanayin yawan zubar jini ya hauhawa, hauhawar jini ya auku, zai kasance daga awanni 12 zuwa 72. Sakamakon shan magani mai yawa, mai haƙuri yana da alamu masu zuwa:

• zafi a gefen dama,
• yawan tashin zuciya da amai,
• farin ciki
• karɓar ƙwayar tsoka ta son rai (rawar jiki),
• ƙaruwar barci
• ruri da rashin daidaituwa game da daidaituwa,
• rashin ci gaba

Alamar da ke sama a cikin mafi yawan lokuta ana haifar da su ta hanyar shan ƙwayoyi a cikin narkewa. A matsayin magani, laushi na ciki ko amai ya zama dole. Don yin wannan, ɗauki carbon mai kunnawa ko wasu adsorbents, kazalika da kayan maye. Zai yiwu akwai lokuta na asibiti na haƙuri da haƙuri glucose.

Yin hulɗa tare da wasu kwayoyi

Ga masu ciwon sukari da yawa, tambayar ta taso game da ko za a iya ɗaukar Glimepiride tare da wasu magunguna banda injections na insulin. Ba shi da sauƙi a ba da amsa. Akwai jerin ƙwayoyi masu yawa waɗanda zasu iya samun tasiri daban-daban akan tasirin glimepiride. Don haka, wasu suna ƙaruwa da tasirin hypoglycemic, yayin da wasu, akasin haka, rage shi.

Dangane da wannan, likitoci suna ba da shawarar sosai ga marassa lafiyar su bayar da rahoton duk canje-canje a cikin yanayin lafiyar su, da kuma cututtukan da suka danganci cutar sankara.

Tebur yana nuna manyan magunguna da abubuwan da ke shafar glimepiride. Yin amfani da su a lokaci ɗaya ba a ke so ba, amma a wasu halaye ana iya tsara shi ƙarƙashin ƙararrun kwararrun masu ba da magani.

Magunguna waɗanda zasu iya inganta tasirin hypoglycemic sune:

• insulin allura
• Fenfluramine,
• Fibrates
• coumarin,
• Yin watsi da su,
• Allopurinol,
• Chloramphenicol
• Santabankan,
• Feniramidol
• Fluoxetine,
• Guanethidine,
• MAO inhibitors, KYAUTA,
• Fankamara
• Sulfonamides,
• ACE masu hanawa
• anabolics
• Proben kashewa,
• Abdullakiman,
• Miconazole
• Pentoxifylline
• Azapropasone
• Lantarki
• quinolones.

Magunguna waɗanda ke rage tasirin sukari lokacin da aka haɗu da glimepiride:

1. Acetazolamide.
2. Corticosteroids.
3. Diazoxide.
4. Diuretics.
5. Sympathomimetics.
6. Hanyoyin kwance
7. Progestogens.
8. Phenytoin.
9. Hormones na thyroid.
10. Estrogens.
11. Phenothiazine.
12. Glucagon.
13. Rifampicin.
14. Barbiturates
15. Acid na Nicotinic
16. Adrenaline.
17. Abubuwan Coumarin.

Hakanan dole ne ku mai da hankali tare da abubuwa kamar su barasa da kuma masu amfani da abubuwan hana karɓa na Harkokin Kiɗa (Clonidine da Reserpine).

Shan magungunan coumarin na iya haɓakawa da rage matakin glycemia a cikin marasa lafiya.

Kudin, sake dubawa da kuma alamun maganin

Kuna iya siyan wannan magani a cikin kantin magani na yau da kullun ko kan shafin yanar gizon masana'antun, bayan ganin hoto na musamman kunshin a gaba.

Zai yuwu a karɓi glimepiride akan sharuɗɗan preferenatory.

Don Glimepiride, farashin ya bambanta dangane da sashi na adadin da adadin allunan a cikin kunshin.

Da ke ƙasa akwai bayani game da tsadar magungunan (Pharmstandard, Russia):

• Glimepiride 1 MG - daga 100 zuwa 145 rubles,
• Glimepiride 2 MG - daga 115 zuwa 240 rubles,
• Glimepiride 3 MG - daga 160 zuwa 275 rubles,
• Glimepepiride 4 MG - daga 210 zuwa 330 rubles.

Kamar yadda kake gani, farashin ya yarda sosai ga kowane mara lafiya, ba tare da la’akari da matakin samun kudin shiga ba. A yanar gizo zaka iya samun bita daban-daban game da magani. A matsayinka na mai mulkin, masu ciwon sukari sun gamsu da aikin wannan magani, kuma banda, kana buƙatar sha shi sau ɗaya kawai a rana.

Sakamakon sakamako masu illa ko maganin contraindications, likita na iya ba da wasu masu maye gurbin. Daga cikinsu, magunguna masu amfani da juna (waɗanda ke da nau'ikan aiki guda ɗaya) da magungunan analog (waɗanda ke ɗauke da abubuwa daban-daban, amma suna da irin tasirin warkewa) an rarrabe su.

Shahararrun samfuran dauke da kayan aiki guda ɗaya sune:

1. Kwayoyin hana daukar ciki Glimepiride Teva magani ne mai inganci wanda yake rage glucose jini. Babban masana'antun sune Isra'ila da Hungary. A cikin Glimepirid Teva, umarnin ya ƙunshi kusan umarnin guda ɗaya da suka danganci amfani da shi. Koyaya, sigogin sun sha bamban da magungunan cikin gida. Matsakaicin farashin 1 fakitin Glimepiride Teva 3 MG No. 30 shine 250 rubles.
2. Glimepiride Canon wani magani ne wanda aka dogara da shi a cikin yaƙar cutar glycemia da alamomin kamuwa da cuta. Hakanan yana samar da Glimepiride Canon a cikin Rasha ta hannun kamfanin samar da magunguna na Canonpharma Production. Glimepiride Canon ba shi da bambance-bambance na musamman, umarnin suna nuna iri ɗaya mai haɗari da haɗarin cutar. Matsakaicin farashin Glimepiride Canon (4 mg No. 30) shine 260 rubles. Magungunan Glimepirid Canon yana da adadi mai yawa na analogues kuma yana iya zama da amfani yayin da maganin bai dace da mai haƙuri ba.

Akwai magunguna da yawa waɗanda suke da irin wannan sakamako na warkewa, misali:

• Metformin sanannen wakili ne na hypoglycemic. Babban bangaren suna iri ɗaya (metformin), a hankali yana rage matakan glucose kuma kusan ba zai taɓa haifar da hauhawar jini ba. Koyaya, Metformin yana da babban jerin abubuwan contraindications da sakamako masu illa. Matsakaicin tsadar magungunan Metformin (500 mg No. 60) shine 130 rubles. Tun da wannan kayan ɓangare ne na adadin ƙwayoyi masu yawa, zaku iya samun samfuran daban-daban - Metformin Richter, Canon, Teva, BMS.
• Sauran magungunan hypoglycemic - Siofor 1000, Vertex, Diabeton MV, Amaril, da dai sauransu.

Don haka, idan saboda wasu dalilai glimepiride bai dace ba, analogues na iya maye gurbin shi. Koyaya, wannan kayan aiki yana da tasiri a cikin haɓakar haɓakar hyperglycemia.

Ana ba da bayani game da mafi kyawun magungunan rage sukari a cikin bidiyon a cikin wannan labarin.

Glimepiride - maganin antidiabetic, magani na hypoglycemic.
Glimepiride wani abu ne wanda yake aiki da karfin jiki wanda ke aiki yayin da aka sha shi a baki, wanda ke cikin kungiyar sulfonylurea. Ana iya amfani dashi don maganin ciwon suga na insulin-insulin mai zaman kansa.
Glimepiride yana aiki da farko ta hanyar ƙarfafa sakin insulin daga ƙwayoyin beta na pancreatic.
Kamar yadda yake tare da sauran ƙwaƙwalwar ƙwaƙwalwa, wannan tasirin yana dogara ne akan haɓakar jijiyar ƙwayoyin ƙwayar ƙwayar cuta zuwa haɓakar jiki na glucose. Bugu da kari, glimepiride yana da tasirin sakamako transpancreatic, shima halayyar wasu abubuwa ne.
Shirye-shiryen Sulfonylurea suna sarrafa ruwan insulin ta hanyar rufe tashar tasirin potassium na ATP wanda ke cikin membrane na beta na pancreatic. Rufe tasirin potassium yana haifar da ɓoyewar ƙwayar beta kuma, sakamakon buɗe tasirin ƙwayoyin calcium, yana haifar da karuwa a cikin kwalliyar alli a cikin sel, wanda, bi da bi, yana haifar da sakin insulin ta hanyar exocytosis.
Glimepiride, tare da babban adadin canzawa, yana ɗaure zuwa furotin na membrane beta-cell wanda ke da alaƙa da tashar tasirin potassium na ATP, kodayake, wurin da aka ɗaure shi ya sha bamban da wurin da aka saba ɗaukar shirye-shiryen sulfonylurea.
Ayyukan Posapancretic
Abubuwan da ke faruwa bayan bayan-sun hada da, alal misali inganta halayyar kashin jiki zuwa insulin da rage amfani da insulin ta hanta.

Alamu don amfani:
Magunguna Glimepiride Ana amfani dashi don magance nau'in ciwon sukari na II wanda ba shi da insulin-insusus ba idan sukari jini ba zai iya kiyaye shi ta hanyar abinci kawai, motsa jiki da kuma asarar nauyi.

Hanyar amfani:
Nasarar da ake samu na kamuwa da cutar kanjamau ya danganta ga marasa lafiya da ke bin abincin da ya dace, aikin jiki na yau da kullun, da kuma sanya idanu akai-akai na jini da fitsarin glucose. Rashin kiyaye abinci ta hanyar marasa lafiya baza a iya biyan diyya ta hanyar shan kwaya ko insulin ba.
Magunguna Glimepiride amfani da manya.
Sashi ya dogara da sakamako na jini da fitsari na yin nazari. Maganin farko shine 1 MG na glimepiride kowace rana. Idan irin wannan kashi yana ba da izinin sarrafa cutar, ya kamata a yi amfani dashi don maganin kulawa.
Idan kulawar glycemic ba ta da kyau, ya kamata a ƙara yawan kashi zuwa 2, 3 ko 4 na glimepiride kowace rana a cikin matakai (tare da tsaka-tsaki na makonni 1-2).
Matsakaicin fiye da 4 MG kowace rana yana ba da kyakkyawan sakamako kawai a lokuta daban-daban. Matsakaicin da aka bada shawarar shine 6 MG na glimepiride kowace rana.
Idan matsakaita mafi girma na yau da kullun na metformin ba ya samar da isasshen sarrafawa na glycemic, za a iya fara amfani da maganin haɗuwa tare da glimepiride.
Biye da matakin farko na metformin, ya kamata a fara amfani da glimepiride tare da ƙarancin kashi, wanda a hankali za a ƙara girma zuwa matsakaicin adadin yau da kullun, yana mai da hankali kan matakin da ake so na sarrafawa na rayuwa. Yakamata ayi amfani da magani a karkashin kulawar likita.
Idan matsakaicin adadin yau da kullun na glimepiride ba ya samar da isasshen sarrafawa na glycemic, ana iya farawa insulin magani idan ya cancanta. Biye da allurar farko na glimepiride, magani insulin yakamata a fara da ƙarancin kashi, wanda a sannan za'a iya ƙaruwa, yana mai da hankali kan matakin da ake buƙata na sarrafawa na rayuwa. Yakamata ayi amfani da magani a karkashin kulawar likita.
Yawancin lokaci, kashi ɗaya na glimepiride kowace rana ya isa. An bada shawara a sha shi jim kaɗan kafin ko lokacin karin kumallo mai zafi ko - idan babu karin kumallo - ɗan lokaci kaɗan kafin ko lokacin farkon cin abinci. Kuskurai a cikin amfani da miyagun ƙwayoyi, alal misali, tsallake matakin na gaba, ba zai taba zama za'a iya gyara ta ta hanyar shan magani mai zuwa ba. Ya kamata a hadiye kwamfutar hannu ba tare da tauna ba, a sha shi da ruwa.
Idan mai haƙuri yana da maganin hypoglycemic a cikin shan glimepiride a kashi na 1 MG kowace rana, wannan yana nuna cewa cutar za a iya sarrafa ta kawai ta hanyar rage cin abinci.
Inganta kulawar ciwon sukari yana tattare da haɓaka mai zurfi ga insulin, don haka buƙatar glimepiride na iya raguwa yayin gudanar da magani. Don guje wa hypoglycemia, ya kamata a rage kashi a hankali ko ya kamata a katse maganin gaba ɗaya. Hakanan ana buƙatar yin bita game da magunguna kuma zai iya tashi idan nauyin jikin mai haƙuri ko salon rayuwa ya canza ko wasu dalilai na ƙara haɗarin cutar hypo- ko hyperglycemia.
Canji daga wakilai na maganin antidiabetic zuwa glimepiride.
Daga wasu magungunan maganin antidiabetic na baki, yawanci yana yiwuwa canzawa zuwa glimepiride. Yayin irin wannan juyawa, yakamata a yi la'akari da ƙarfi da rabin rayuwar wakili na baya. A wasu halaye, musamman idan maganin antidiabetic yana da tsawon rabin rayuwa (alal misali, chlorpropamide), ana bada shawara a jira fewan kwanaki kafin a fara glimepiride. Wannan zai rage haɗarin maganganun hypoglycemic saboda karɓar sakamako na wakilai biyu.
Yarin shawarar farawa shine 1 MG na glimepiride kowace rana. Kamar yadda aka ambata a sama, za a iya ƙara yawan kashi a matakai, la'akari da halayen maganin.
Canji daga insulin zuwa glimepiride.
A cikin lokuta na musamman, ana iya nuna masu haƙuri da masu ciwon sukari na nau'in II waɗanda ke shan insulin don maye gurbin su da glimepiride. Ya kamata a aiwatar da irin wannan canji karkashin kulawar likita.

Sakamako masu illa:
La'akari da gwaninta na amfani da glimepiride da sauran abubuwan da ake amfani da su na sulfonylurea, ya zama dole muyi la’akari da yiwuwar tasirin halayen da aka bayyana a kasa ta bangarorin tsarin gabobin a rage yawan lokutan: sau da yawa ≥ 1/10, sau da yawa: ≥ 1/100 zuwa glimepiride magani don rage sukari a cikin ciwon sukari