Umarnin Diabeton mv don amfani, contraindications, sakamako masu illa, sake dubawa

Oral hypoglycemic magani daga rukuni na sulfonylurea abubuwan asali na ƙarni na biyu.
Shiri: DIABETON® MV
Aiki mai guba na miyagun ƙwayoyi: gliclazide
Lullukin ATX: A10BB09
KFG: Magungunan maganin ƙwaƙwalwa na baka
Lambar yin rijista: P No. 011940/01
Ranar rajista: 12.29.06
Mai mallaka reg. doc.: Les Laboratoires SERVIER

Sakin tsari na masu ciwon sukari mv, kwayar magunguna da abubuwan da aka tsara.

Allunanda aka sake su sun zama fari, suna kan gado, tare da zane a bangarorin biyu: akan ɗayan alamar kamfanin, a ɗayan - DIA30.

Shafin 1
gliclazide
30 MG

Wadanda suka kware: sinadarin hydrogen phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, dioxide dioxide na anhydrous.

30 inji mai kwakwalwa - blister (1) - fakitoci na kwali.
30 inji mai kwakwalwa - blister (2) - fakitoci na kwali.

Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Aikin magunguna na ciwon sukari mv

Magungunan hypoglycemic na baki daga rukuni na abubuwan da suka samo asali na sulfonylurea na ƙarni na biyu, wanda ya bambanta da irin waɗannan kwayoyi ta hanyar haɗuwa da zobe na heterocyclic na N-wanda ke da haɗin haɗin endocyclic.

Diabeton MB yana rage glucose jini ta hanyar tsoratar da rufin insulin ta hanyar sel isger. Bayan shekaru 2 na jiyya, yawancin marasa lafiya ba sa ci gaba da jaraba ga ƙwayoyi (ƙara yawan matakan insprandial insulin da ɓoye na C-peptides ya kasance).

A cikin nau'in 2 na ciwon sukari na mellitus (wanda ba shi da insulin-insulin ba), ƙwayar ta mayar da farkon farkon ɓoye insulin a cikin martani ga ciwan glucose kuma yana haɓaka kashi na biyu na ɓoye insulin. Ana lura da hauhawar ƙwayar insulin a cikin martani ga tashin hankali saboda ci abinci da kuma gulukos.

Gliclazide yana da tasirin karin magana, i.e. yana kara karfin jijiyar sel zuwa insulin.

A cikin ƙwayar tsoka, sakamakon insulin akan tasirin glucose, saboda haɓaka haɓaka ƙimar ƙwayar yanki zuwa insulin, yana ƙaruwa sosai (+ 35%). Wannan tasirin gliclazide shine saboda gaskiyar cewa yana haɓaka aikin insulin a kan ƙwayar glycogen synthetase kuma yana haifar da canje-canje na post-transcriptional a cikin GLUT4 dangane da glucose.

Diabeton MB yana rage haɓakar glucose a cikin hanta, yana daidaita dabi'ar glucose mai azumi.

Bugu da ƙari ga tasirin sa akan metabolism metabolism, gliclazide yana inganta microcirculation. Magungunan yana rage haɗarin ƙananan ƙwayar jijiyoyin jini, yana shafar hanyoyin 2 waɗanda zasu iya shiga cikin ci gaba da rikice-rikice a cikin ciwon sukari mellitus: hanawa cikin haɗuwar platelet da adhesion da raguwa a cikin abubuwanda ke haifar da abubuwan kunnawa na platelet (beta-thromboglobulin, thromboxane B2), kazalika da sake dawo da fibrinolytic Aiki na jijiyoyin bugun zuciya da haɓaka aikin ƙwaƙwalwar ƙwayar jini.

Gliclazide yana da kaddarorin antioxidant: yana rage matakin liro peroxides a cikin jini, yana kara yawan aikin sel jini superoxide dismutase.

Pharmacokinetics na miyagun ƙwayoyi.

Tsotsa da rarrabawa

Bayan shan miyagun ƙwayoyi a ciki, gliclazide ya cika komai daga narkewa. Cutar da gliclazide a cikin plasma yana ƙaruwa ci gaba, yana kaiwa zuwa yankin farawa 6-12 hours bayan gudanarwa. Cin abinci baya shafar matakin sha. Musamman daidaiku yana da ɗan ƙanƙantar da hankali. Dangantaka tsakanin kashi da maida hankali ne na ƙwayar cuta dogara ne akan lokaci.

Aya daga cikin kashi ɗaya na yau da kullun na Diabeton MB 30 MG yana ba da ingantaccen taro na ƙwayar glycazide fiye da awanni 24.

Shafaffen furotin na Plasma kashi 95%.

Gliclazide yana cikin metabolized da farko a cikin hanta. Sakamakon metabolites ba shi da aikin magunguna.

T1 / 2 kimanin awa 16 ne (awanni 12 zuwa 20). Ana cire shi ta hanyar kodan a cikin hanyar metabolites, ƙasa da 1% - tare da fitsari a cikin canzawa.

Sashi da hanyar gudanar da magani.

Magungunan an yi niyya ne kawai ga manya (gami da marasa lafiya shekaru 65 da haihuwa). Girman farawa da aka bada shawarar shine 30 MG.

Ya kamata a aiwatar da zaɓi gwargwado daidai da matakin glucose a cikin jini bayan farawar magani. Kowane canji na gaba na iya aiwatarwa bayan akalla tsawon makonni 2.

Tare da maganin kulawa, kashi ɗaya na yau da kullun yana samar da ingantaccen iko na matakan glucose jini. Yawan maganin yau da kullun na iya bambanta daga MG 30 (1 tab.) Zuwa 90-120 mg (3-4 shafin.). Matsakaicin adadin yau da kullun shine 120 MG.

Ana shan maganin a baki sau 1 / rana yayin karin kumallo.

Idan ka rasa ɗayan ko fiye na maganin, ba za ku iya ɗaukar mafi girma kashi a kashi na gaba ba.

Ga marasa lafiya waɗanda ba su karɓi magani a baya ba, kashi na farko shine 30 MG. Sannan an zabi kashi daban daban har sai an sami sakamako mai warkewa.

Diabeton MV na iya maye gurbin Diabeton a allurai daga alluna 1 zuwa 4 a rana.

Canzawa daga wani magani na hypoglycemic zuwa Diabeton MB baya buƙatar kowane lokaci na canji. Dole ne a fara dakatar da shan ƙwayar maganin hypoglycemic sannan kawai sai a rubuto Diabeton MB.

Za a iya amfani da diabeton MB a hade tare da biguanides, alpha-glucosidase inhibitors ko insulin.

Ga tsofaffi marasa lafiya, shawarar da aka ba da shawarar iri ɗaya daidai ce da ta marasa lafiya waɗanda shekarunsu ba su kai 65 ba.

Idan mara lafiya ya taɓa karɓar magani tare da ƙayyadaddun abubuwan sulfonylurea tare da T1 / 2 mai tsawo (alal misali, chlorpropamide), to, saka idanu a hankali (kula da matakin glycemia) ya wajaba don makonni 1-2 don gujewa haɓakar haɓakawar jini a sakamakon tasirin tasirin maganin da ya gabata.

A cikin marasa lafiya tare da gazawar matsakaici na matsakaici zuwa matsakaici (CC daga 15 zuwa 80 ml / min), an tsara maganin a daidai gwargwado kamar yadda yake a cikin marasa lafiya tare da aikin na al'ada.

Cutar sakamako Diabeton mv:

Daga tsarin endocrine: hypoglycemia mai yiwuwa ne.

A ɓangaren tsarin narkewa: tashin zuciya, zawo ko maƙarƙashiya yana yiwuwa (ƙarancin da aka lura lokacin da aka tsara miyagun ƙwayoyi a lokacin abinci), da wuya - karuwar ayyukan AST, ALT, alkaline phosphatase, a wasu yanayi - jaundice.

Daga tsarin hawan jini: da wuya - anemia, leukopenia, thrombocytopenia.

Allergic halayen: da wuya - itching, urticaria, maculopapular fatar.

Contraindications wa miyagun ƙwayoyi:

- ciwon sukari mellitus type 1 (insulin-dogara),

- mai ciwon sukari ketoacidosis, mai ciwon sukari, mai ciwon sukari,

Mai tsananin na koda ko hepatic gazawar,

- sarrafa miconazole na lokaci daya,

- lactation (shayarwa),

- yara da matasa a shekaru 18,

- Hypersensitivity to gliclazide ko wani daga cikin magabata na miyagun ƙwayoyi, sauran abubuwan da suka samo asali na sulfonylurea, sulfonylamides.

Ba'a ba da shawarar amfani da miyagun ƙwayoyi a hade tare da phenylbutazone ko danazole.

Yi amfani da lokacin daukar ciki da lactation.

Babu isasshen bayanan asibiti don tantance haɗarin yiwuwar ɓarna da tasirin fata sakamakon amfani da gliclazide yayin daukar ciki. Saboda haka, yin amfani da masu ciwon sukari MV a cikin wannan rukuni na marasa lafiya yana contraindicated.

Lokacin da ciki ya faru yayin shan maganin, babu wani tabbataccen dalilin dakatarwa. A cikin irin waɗannan halaye, har ma a yanayin da ake shirin ɗaukar ciki, ya kamata a dakatar da miyagun ƙwayoyi kuma ya kamata a ci gaba da shirye-shiryen insulin a cikin kulawa ta kusa da dukkanin alamu na dakin gwaje-gwaje na metabolism metabolism. Hakanan ana bada shawarar saka idanu akan sabon abu na glucose na jini.

Ba'a sani ba ko an keɓance gliclazide a cikin madara; babu shaidar haɗarin haɓakar ƙwayar tsohuwar ƙwayar cuta. Dangane da wannan, magani tare da gliclazide yayin shayar da jarirai nono.

A cikin nazarin dabba na gwaji, an nuna cewa abubuwan da ake amfani da su na sulfonylurea a cikin manyan allurai suna da tasirin teratogenic.

Umarnin na musamman don amfani da masu ciwon sukari mv.

Lokacin da ake rubuta MBA Diabeton MB, yakamata a haɗu da cewa hypoglycemia na iya haɓaka sakamakon shan magungunan sulfonylurea, kuma a wasu yanayi a cikin mummunan yanayi da tsawaitawa, yana buƙatar asibiti da gudanarwar glucose na kwanaki.

Don guje wa ci gaban hypoglycemia, zaɓi mai hankali da zaɓin marasa lafiya, da kuma samar wa mai haƙuri cikakken bayani game da maganin da aka ƙaddamar, ya zama dole.

Lokacin amfani da magungunan hypoglycemic a cikin tsofaffi marasa lafiya, mutanen da koyaushe ba su samun isasshen abinci mai gina jiki, tare da raunana yanayin gaba ɗaya, a cikin marasa lafiya da ke fama da adrenal ko pituitary insufficiency, haɗarin haɓakar haɓakar jini yana ƙaruwa.

Bayyanar cututtukan hypoglycemia suna da wuya a gane a cikin tsofaffi da kuma a cikin marasa lafiya da ke karɓar maganin beta-blocker.

Lokacin da ake tsara Diabeton MV ga marasa lafiya tsofaffi, lura da hankali akan matakan glucose na jini ya zama dole. Yakamata a fara jiyya a hankali kuma a cikin kwanakin farko na farji ya zama dole don sarrafa glucose mai azumi da kuma bayan cin abinci.

Za a iya rubuta shi ne kawai ga masu haƙuri da ke karbar abinci na yau da kullun, wanda dole ya haɗa da karin kumallo da kuma samar da isasshen wadataccen carbohydrates. Hypoglycemia sau da yawa yana haɓaka tare da rage cin abinci mai kalori, bayan tsawanta ko motsa jiki mai ƙarfi, bayan shan giya, ko yayin shan magunguna masu yawa da yawa a lokaci guda.

Lokacin da alamun cututtukan cholestatic jaundice suka bayyana, ya kamata a dakatar da jiyya. Bayan katse Diabeteson MB, waɗannan alamu galibi sukan ɓace.

A cikin marasa lafiya tare da mummunan hepatic da / ko gazawar renal, canji a cikin kantin magani da / ko sifofin magunguna na gliclazide yana yiwuwa. Musamman, raunin hepatic mai zafi ko gazawar na iya shafar rarraba gliclazide a cikin jiki. Hakanan karancin maganin hepatic zai iya taimakawa rage glucogenesis. Wadannan tasirin suna ƙara haɗarin haɓaka yanayin hauhawar jini. Abun jinin haila wanda ke tasowa a cikin waɗannan marasa lafiya na iya zama tsawon lokaci, a cikin irin waɗannan halayen, magani na dacewa ya zama dole.

Gudanar da matakan glucose na jini a cikin marasa lafiya da ke karɓar wakilai na hypoglycemic za a iya raunana a cikin waɗannan lamurran masu zuwa: zazzabi, rauni, cututtukan da ke ɗauka ko ayyukan tiyata. A cikin irin waɗannan yanayi, yana iya zama dole a dakatar da jiyya tare da masu ciwon sukari MV kuma a tsara maganin insulin.

Ingancin Diabeton MB (har ma da wasu magunguna na baka) a wasu marasa lafiya suna jin daɗin raguwa bayan dogon lokaci. Wannan na iya zama saboda ci gaban ciwon sukari ko ƙarancin martani ga maganin. An san wannan sabon abu a matsayin juriya na miyagun ƙwayoyi, wanda dole ne a bambanta shi da na farko lokacin da aka tsara maganin a karon farko kuma baya fitar da tasirin da ake tsammanin. Kafin bincikar mai haƙuri tare da ƙarancin ilimin magani, ya zama dole a tantance ƙimar zaɓi na ɗabi'a da kuma yarda da haƙuri tare da abincin da aka tsara.

A kan tushen aikin jiyya tare da Diabeton MB, ba a bada shawarar phenylbutazone da danazole ba. Zai fi kyau a yi amfani da wani NSAID.

A kan tushen ilimin aikin kwantar da hankali tare da Diabeton MB, ya zama dole a bar yin amfani da barasa ko magunguna, wanda ya haɗa da ethanol.

Wajibi ne a sanar da mara lafiya da danginsa game da hadarin kamuwa da cututtukan jini, alamunta da kuma yanayin da ke kawo ci gabanta. Hakanan wajibi ne a bayyana menene juriya da magunguna na farko da na sakandare. Dole ne a sanar da mara lafiyar game da haɗarin haɗari da fa'idoji na maganin da aka gabatar, kuma lallai ne a gaya masa game da sauran nau'ikan maganin. Marasa lafiya yana buƙatar bayyana mahimmancin daidaitaccen abincin, da buƙatar motsa jiki na yau da kullun da saka idanu na yau da kullum kan alamu na jini da kuma alamomin glucose na fitsari.

Kulawar dakin gwaje-gwaje

Wajibi ne don sanin matakan glucose da haemoglobin glycosylated a cikin jini, abubuwan da ke cikin glucose a cikin fitsari.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Marasa lafiya yakamata su san alamun hypoglycemia kuma suna amfani da taka tsantsan yayin tuki ko yin aikin da ke buƙatar babban adadin halayen psychomotor.

Adadin yawa na miyagun ƙwayoyi:

Bayyanar cututtuka: hypoglycemia, a cikin manyan lokuta - tare da coma, ƙuruciya da sauran raunin jijiyoyin jiki.

Jiyya: Ana daidaita alamu na hypoglycemia masu tsayi ta hanyar shan carbohydrates, zaɓi sashi da / ko canza abincin. Dole ne a ci gaba da lura da yanayin mai haƙuri har sai likitan da ke halartar ya tabbata cewa lafiyar mai haƙuri ba ta cikin haɗari. A cikin mawuyacin yanayi, likita na gaggawa da kuma asibiti kai tsaye ya zama dole.

Idan ana zargin ko cutar ta haihuwar hypoglycemic, ana haƙuri da sauri cikin haƙuri tare da 50 ml na babban maganin dextrose (glucose) 40% iv. Sannan, ana samarda mafi kyawun maganin gurbataccen bayani (glucose) na kashi 5% cikin jijiya domin yaada matsayin da yakamata a jikin glucose a cikin jini. Dole ne a gudanar da kulawa da hankali aƙalla a cikin sa'o'i 48 masu zuwa .. A nan gaba, dangane da yanayin mai haƙuri, tambayar ya buƙaci ƙarin sa ido kan mahimman ayyukan mai haƙuri.

A cikin marasa lafiya da cututtukan hanta, ƙaddamar da plasma na gliclazide na iya jinkirta. Yawancin lokaci ana yin maganin dialysis don irin waɗannan marasa lafiya saboda ƙayyadaddun ƙaddarar gliclazide zuwa ƙwayoyin plasma.

Haɗaɗɗar Diabeton MV tare da wasu kwayoyi.

Magunguna waɗanda ke inganta tasirin Diabeton MB

Amfani da guda ɗaya na Diabeton MB tare da miconazole (don amfani da tsari) yana haɓaka yiwuwar haɓakar haɓakar jini har zuwa guda biyu.

Ba a shawarar haɗuwa da haɗin guiwa ba

Phenylbutazone (don amfani na tsari) yana haɓaka tasirin sakamako na abubuwan da aka samo asali na sulfonylurea, kamar yadda yana maye gurbin abubuwan haɗinsu da ƙwayoyin plasma da / ko yana rage jinkirin fitar da su daga jiki.

Tare da yin amfani da Diabeton MB na lokaci guda, ethanol da ethanol dauke da kwayoyi suna ƙaruwa da hypoglycemia, yana hana halayen ramuwa, kuma suna iya ba da gudummawa ga haɓakar ƙwaƙwalwar ƙwayar cuta.

Musamman kiyayewa

Amfani da beta-blockers yana amfani da lokaci ɗaya rufe wasu alamun cututtukan hypoglycemia, irin su palpitations da tachycardia. Yawancin masu hana beta-blockers suna ƙaruwa da ƙaruwa da kuma tsananin hypoglycemia.

Fluconazole yana ƙara tsawon lokacin T1 / 2 sulfonylureas kuma yana ƙaruwa da haɗarin hypoglycemia.

Amfani guda ɗaya na masu hana ACE (captopril, enalapril) na iya lalata sakamakon hypoglycemic na abubuwan da suka samo asali na sulfonylurea (bisa ga hasashe guda ɗaya, an inganta haɓakar glucose tare da raguwa a cikin bukatun insulin). Abun da yakamata a jiki ya zama ruwan dare.

Magunguna waɗanda ke raunana tasirin Diabeton MV

Ba da shawarar yin haɗuwa ba

Tare da yin amfani da lokaci guda tare da danazol, raguwar tasiri na Diabeton MB yana yiwuwa.

Musamman kiyayewa

Haɗewar yin amfani da Diabeton MB tare da chlorpromazine a cikin allurai masu yawa (fiye da 100 mg / rana) na iya haifar da karuwa a cikin matakan glucose na jini sakamakon raguwar ƙwayar insulin.

Tare da yin amfani da GCS na lokaci guda (don tsari, na waje da na gida) da kuma tetracosactides, matakan glucose na jini suna ƙaruwa tare da yiwuwar ci gaban ketoacidosis (raguwa a cikin haƙuri a ƙarƙashin tasirin GCS).

Tare da yin amfani da Diabeton MB na lokaci guda tare da progestogens, yakamata ayi la'akari da cutar sikari ta cikin kwayoyi masu yawa.

Lokacin amfani tare, 2-adrenoreceptor mai kara kuzari (don amfani da tsari) - ritodrin, salbutamol, terbutaline haɓaka glucose na jini (kula da matakan glucose na jini ya kamata, idan ya cancanta, canja wurin haƙuri zuwa insulin na iya zama dole).

Idan ya cancanta, yin amfani da abubuwan haɗuwa da ke sama yakamata su samar da matakan matakan glucose na jini. Yana iya zama mahimmanci don daidaitawa sashi na Diabeton MB duka yayin lokacin maganin haɗin gwiwa da kuma bayan dakatar da ƙarin magani.

Formaddamar da tsari da abun da ke ciki

Form sashi - Allunan sakin allunan.

Abinda ke ciki kowace kwamfutar hannu 1:

Abunda yake aiki: Gliclazide - 60.0 mg.
Wadanda suka kware: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cP. 160.0 mg, magnesium stearate 1.6 mg, silicon dioxide colloidal anhydrous 5.04 mg.

Pharmacodynamics

Gliclazide magani ne na silonylurea, magani ne na tsoka wanda ya bambanta da irin kwayoyi irin wannan ta hanyar kunshe da heterocyclic zobe na N-dauke da jigilar endocyclic.

Glyclazide yana saukar da glucose na jini ta hanyar karfafa rufin insulin ta sel beta na tsibirin na Langerhans. Increaseara yawan matakan insprandial insulin da C-peptide sun ci gaba bayan shekaru 2 na maganin.

Baya ga tasirin metabolism na metabolism, gliclazide yana da tasirin jijiyoyin jini.

Tasirin cutar sankarar jiki

Glyclazide yana rage haɗarin ƙananan ƙwayar jini na jini, yana haifar da hanyoyin da zasu iya haifar da ci gaba da rikice-rikice a cikin ciwon sukari mellitus: hanawa da tarawar platelet da adhesion da raguwa a cikin abubuwanda ke haifar da platelet (beta-thromboglobulin, thromboxane B2), kazalika da sake dawo da aiki na fibrinoly increasedara yawan aikin ƙwayar plasminogen mai aiki.

Damuwa

Bayan gudanar da baki, gliclazide yana cikin komai. Yawan taro na gliclazide a cikin plasma jini yana ƙaruwa a hankali a cikin awanni 6 na farko, ana kula da matakin filayen daga 6 zuwa 12 sa'o'i.

Musamman daidaiku sun yi karanci. Cin abinci baya shafar yawan ko yawan sha na gliclazide.

Tsarin rayuwa

Gliclazide yana cikin metabolized da farko a cikin hanta. Babu ƙwayoyin metabolites mai aiki a cikin jini.

Glyclazide yana daɗaɗɗen ƙwayoyin kodan: an fitar da excretion a cikin hanyar metabolites, ƙasa da 1% an cire ta da kodan ba canzawa .. Rabin rabin gliclazide yana kan matsakaici daga sa'o'i 12 zuwa 20.

Alamu don amfani

An tsara magungunan masu ciwon sukari MV 60 MG ga marasa lafiya da shekarunsu suka wuce 18 don lura da halaye masu zuwa:

Nau'in nau'in ciwon sukari na 2 da ƙarancin ingantaccen aikin maganin abinci, aikin jiki da asarar nauyi.
Yin rigakafin rikice-rikice na ciwon sukari mellitus: rage haɗarin microvascular (nephropathy, retinopathy) da rikice-rikice na macrovascular (infarction na myocardial, rauni) a cikin marasa lafiya da nau'in ciwon sukari na 2 na mellitus ta hanyar sarrafa glycemic mai ƙarfi.

Sashi da gudanarwa

Wannan magani an wajabta shi kawai ga manya!

Ya kamata a dauki maganin da aka bada shawarar a baki, a sau 1 a lokacin karin kumallo. Girman yau da kullun na iya zama 30 -120 mg (1/2 -2 Allunan) a cikin kashi ɗaya. An ba da shawarar haɗiye kwamfutar hannu ko rabin kwamfutar hannu gaba ɗaya ba tare da tauna ko murƙushewa ba.

Idan ka rasa magunguna ɗaya ko sama ɗaya, baza ku iya ɗaukar babbar magani a kashi na gaba ba, yakamata ku ɗauki kashi da kuka ɓace gobe.

Kamar yadda yake tare da sauran magunguna na hypoglycemic, dole ne a zaɓi sashi na miyagun ƙwayoyi a kowane yanayi dangane da tattarawar glucose jini da HbAlc.

Sigar farko

Maganin da aka ba da shawarar farko (ciki har da ga tsofaffi marasa lafiya 30 MG kowace rana (1/2 kwamfutar hannu).

Game da isasshen iko, ana iya amfani da magani a cikin wannan adadin don maganin kulawa. Tare da rashin isasshen iko na glycemic, ana iya ƙara adadin kwayoyi na yau da kullun zuwa 60, 90 ko 120 MG.

Increaseara yawan kashi yana yiwuwa ba da farko ba bayan watan 1 na maganin ƙwaƙwalwar ƙwayar cuta a ƙayyadadden maganin da aka tsara a baya. Banda shi ne marasa lafiya waɗanda ba su raguwa da glucose din jini ba bayan makonni 2 na maganin. A irin waɗannan halayen, ana iya ƙara kashi 2 makonni biyu bayan farawar gudanarwa.

Matsakaicin shawarar da aka bayar na yau da kullun na miyagun ƙwayoyi shine 120 MG.

1 kwamfutar hannu na magungunan Diabeton® MV Allunan tare da ingantaccen saki na 60 MG daidai yake da Allunan Allunan 2 na Diabeton® MV Allunan tare da sakewa saki 30 MG Kasancewar daraja a kan allunan 60 MG na allunan yana ba ka damar raba kwamfutar hannu kuma ɗaukar nauyin kullun na 30 MG (1/2 kwamfutar hannu 60 mg), kuma, idan ya cancanta, 90 MG (1 da 1/2 kwamfutar hannu 60 mg).

Sauyawa daga wani wakili na hypoglycemic zuwa Diabeton MV 60 MG

Diabeton®: MV Allunan tare da ingantaccen saki na 60 MG za'a iya amfani dashi maimakon wani maganin hypoglycemic don maganin baka. Lokacin canja wurin marasa lafiya da ke karɓar wasu magunguna na hypoglycemic don sarrafawa na baka zuwa Diabeton® MV, yakamata a yi la'akari da kashi da rabin rayuwa. A matsayinka na mai mulkin, ba a bukatar lokacin juyawa. A kashi na farko yakamata ya zama mil 30 sannan sannan akasashi ya danganta da maida hankali kan glucose na jini. Lokacin da aka maye gurbin Diabeton® MV tare da ƙayyadaddun sulfonylurea tare da ƙara tsawon rabin rayuwa don guje wa hypoglycemia wanda ke haifar da ƙari ta hanyar abubuwan haɗin jini guda biyu, zaku iya dakatar da shan su na kwanaki da yawa.

Kashi na farko na maganin Diabeton® MV shine 30 MG (1/2 kwamfutar hannu 60 mg) kuma, idan ya cancanta, za'a iya karuwa nan gaba, kamar yadda aka bayyana a sama.

Marasa lafiya a Hadarin Hypoglycemia

A cikin marasa lafiya da ke cikin haɗarin haɓakar hypoglycemia (ƙarancin abinci mai gina jiki ko rashin daidaituwa, mai rauni ko raunin rashin lafiyar endocrine: ƙarancin ƙwaƙwalwar adanar ƙasa, hypothyroidism, janyewar glucocorticosteroids (GCS) bayan tsawaita amfani da / ko gudanarwa a cikin manyan allurai, mummunan cututtuka na cututtukan zuciya. tsarin - mummunan cututtukan zuciya, mummunan atherosclerosis na carotid arteries, atherosclerosis na kowa), an bada shawarar amfani da mafi ƙarancin (30 MG) na miyagun ƙwayoyi. Diabeton® MV.

Yin rigakafin rikicewar cututtukan siga

Don cimma daidaitaccen iko na glycemic, zaku iya ƙara yawan adadin Diabeton to MV zuwa 120 mg / rana, ban da abinci da motsa jiki, don cimma burin HbAlc. Lura da hadarin kamuwa da cututtukan jini. Bugu da ƙari, sauran magungunan hypoglycemic, alal misali, metformin, mai hana alpha-glucosidase inhibitor, hyazolidinedione na asali ko insulin, ana iya ƙara shi zuwa far.

Yin amfani da miyagun ƙwayoyi yayin daukar ciki da lactation

Babu bayanai game da yuwuwar yin amfani da allunan na Diabeton MV a lokacin haihuwar mace. Duk da cewa binciken dabbobi bai tabbatar da tasirin cutar tamotogenic da tayin mahaifar ba, an sanya wannan magani don maganin mata masu juna biyu. Idan an gano cutar sankarau a cikin mata yayin daukar ciki, an zaɓi mai haƙuri a madadin magani wanda zai zama ƙasa da haɗari ga tayin. A wannan yanayin, likita koyaushe yana lura da yanayin matar gaba daya.

Idan an kula da mace tare da masu ciwon sukari MV, kuma ciki ya rigaya ya fara, ya kamata a dakatar da magani nan da nan kuma a nemi likita, tabbatar da sanar game da shan maganin.

An haramta amfani da wannan maganin cututtukan jini yayin shayarwa, tun da abubuwan da ke tattare da maganin suna iya shiga cikin madara, sannan kuma sai su shiga jikin jariri. Idan ya cancanta, yakamata a dakatar da aikin magani.

Hypoglycemia

Kamar sauran magunguna na ƙungiyar sulfonylurea, ƙwayar cutar Diabeton MV na iya haifar da ƙwayar cutar hypoglycemia a cikin yanayi na talauci kuma musamman idan aka rasa cin abincin. Bayyanar alamun alamomin hypoglycemia: ciwon kai, matsananciyar yunwar, tashin zuciya, matsananciyar ƙarfi, yawan gajiya, tashin hankali, tashin hankali, ragi, raguwar tashin hankali, rashi, damuwa, hangen nesa da magana, aphasia, rawar jiki, paresis, asarar iko da kai. , jin rashin taimako, tsinkaye mara kyau, buguwa, kasala, rashi, bradycardia, hanji, numfashi mara nauyi, nutsuwa, asarar sani tare da yuwuwar ci gaba, na rashin nasara, har zuwa mutuwa.

Hakanan za'a iya lura da halayen Andrenergic: ƙara yawan zufa, fata "m", damuwa, tachycardia, haɓakar jini, palpitations, arrhythmia, da angina pectoris.

A matsayinka na mai mulkin, ana dakatar da alamun hypoglycemia ta hanyar shan carbohydrates (sukari).

Shan masu zaki shine bashi da amfani. A cikin asalin wasu hanyoyin da aka samo asali na maganin sulfonylurea, an lura da komawar hypoglycemia bayan nasarar da ta samu.

A cikin tsananin rauni ko tsawan jini, ana nuna kulawa ta gaggawa akan likita, watakila tare da asibiti, koda kuwa akwai wani tasiri daga shan carbohydrates.

Sauran sakamako masu illa

Daga cikin jijiyoyin jiki: zafin ciki, tashin zuciya, amai, gudawa, maƙarƙashiya. Shan magungunan yayin karin kumallo yana hana waɗannan bayyanar cututtuka ko rage su.
A wani ɓangaren fata da ƙananan ƙwaƙwalwar ƙwayar fata: fatar jiki. itching urticaria, Quincke's edema, erythema, maculopapullous fyaɗe, halayen tsoro (kamar su Stevens-Jones syndrome da guba mai ƙwayar cuta necrolysis).
Hematopoietic gabobin da tsarin lymphatic: cututtukan cututtukan jini na jini (anaemia, leukopenia, thrombocytopenia, granulocytopenia) suna da wuya.
A ɓangaren hanta da ƙwayar biliary: ƙara yawan aiki na enzymes "hanta" (aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (lokuta da kebe). Idan cutar yolestice ta faru, yakamata a dakatar da maganin.
Daga gefen bangaren hangen nesa: rikicewar gani na yau da kullun na iya faruwa saboda canji a cikin taro na jini, musamman a farkon farawa.

Yin hulɗa tare da wasu kwayoyi

Magungunan Diabeton MV 60 MG bai kamata a sha lokaci ɗaya tare da miconazole ba, tun da wannan hulɗa yana haifar da haɓaka sakamako na hypoglycemic, wanda zai iya haifar da haɓakar ƙwaƙwalwar ƙwayar cuta.

Wannan miyagun ƙwayoyi na iya rage tasirin cututtukan hana haihuwa, saboda haka, ya kamata a faɗakar da marasa lafiya da ke amfani da wannan hanyar kariya game da haɗarin yin ciki mara amfani.

Ba a bada shawarar yin amfani da miyagun ƙwayoyi tare da kwayoyi waɗanda suka haɗa da ethanol, saboda wannan na iya haifar da karuwa a cikin tasirin hypoglycemic da haɓaka raunin hanta mai ƙarfi.

Sharuɗɗan hutu na kantin

Wadannan kwayoyi sune analogues na miyagun ƙwayoyi masu ciwon sukari MV:

Allunan glidiab
Glidiab MV,
Diabefarm MV,
Gliclazide MV.

Kafin maye gurbin maganin da aka tsara tare da analog, mai haƙuri yakamata ya nemi shawarar endocrinologist.

Matsakaicin farashin magungunan Diabeton MV 60 MG a cikin kantin magunguna na Moscow shine 150-180 rubles a kowace fakiti (allunan 30).

Tsari sashi:

Abun ciki:
Tabletaya daga cikin kwamfutar hannu ya ƙunshi:
Aiki mai aiki: gliclazide - 60.0 mg.
Fitowa: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cp 160,0 mg, magnesium stearate 1.6 mg, anhydrous colloidal silicon dioxide 5.04 mg.

Bayanin
Farar fata, biconvex, allunan kwalaji mai kwalliya da zane da zane "DIA" "60" a garesu.

Rukunin Magunguna:

Lambar ATX: A10BB09

MAGANAR PHARMACOLOGICAL

Pharmacodynamics
Glyclazide shine mai samo asali na sulfonylurea, magani na baka na hypoglycemic wanda ya bambanta da kwayoyi masu kama da wannan ta hanyar ringin N-dauke da heterocyclic ring tare da haɗin endocyclic.
Gliclazide yana rage haɗuwar glucose jini, yana ƙarfafa ɓoye insulin ta β-sel daga tsibirin na Langerhans. Increaseara yawan ƙwaƙwalwar insprandial insulin da C-peptide sun ci gaba bayan shekaru 2 na maganin.
Baya ga tasirin metabolism na metabolism, gliclazide yana da tasirin jijiyoyin jini.

Tasiri kan rufin insulin
A cikin nau'in 2 na ciwon sukari na mellitus, ƙwayar ta sake farawa farkon farkon ƙwayar insulin a cikin martani ga ciwan glucose kuma yana haɓaka kashi na biyu na ɓoye insulin. An lura da haɓakar ƙwayar insulin a cikin martani ga tashin hankali saboda ci abinci ko gudanarwar glucose.

Tasirin cutar sankarar jiki
Glyclazide yana rage haɗarin ƙananan ƙwayar jini na jini ta hanyar tasirin hanyoyin da zasu iya haifar da ci gaba da rikice-rikice a cikin ciwon sukari mellitus: hanawa cikin haɗuwar platelet da adhesion da raguwa a cikin abubuwanda ke haifar da abubuwan kunnawa na platelet (beta-thromboglobulin, thromboxane B₂), kazalika da dawo da ayyukan fibrinolytic na endothelium na jijiyoyin jiki da kuma kara yawan aikin mai kunna jini na plasminogen.
Gudanar da glycemic mai ƙarfi dangane da yin amfani da Diabeton ® MV (HbA1c dabarun sarrafa glycemic mai ƙarfi ya haɗa da alƙawarin magani na Diabeton increasing MV da haɓaka ƙaddararsa a kan asalin cutar (ko kuma a maimakon) daidaitaccen magani kafin ƙara wani magani na hypoglycemic (misali metformin, alpha-glucosidase inhibitor) thiazolidinedione na asali ko insulin.) Matsakaicin yawan maganin yau da kullun na maganin cutar sankara ® MV a cikin marasa lafiya a cikin ƙungiyar kulawa mai ƙarfi shine 103 mg, matsakaicin kullun kashi 60 yakai.
A kan tushen amfani da miyagun ƙwayoyi Diabeton ® MV a cikin ƙungiyar kulawa mai ƙarfi na glycemic (matsakaicin biyewa shekaru 4.8, matsakaici matakin HbA1c 6.5%) idan aka kwatanta da ƙungiyar kulawa mai kyau (matsakaici matakin HbA1c 7.3%), an nuna raguwa mai yawa na 10% haɗarin haɗari na haɗarin mitar macro- da rikitarwa na microvascular
An sami fa'idar ta hanyar rage girman haɗarin: manyan rikicewar ƙananan ƙwayoyin cuta ta hanyar 14%, farawa da ci gaban nephropathy da kashi 21%, abin da ya faru na microalbuminuria da 9%, macroalbuminuria da 30% da haɓakar rikicewar koda na 11%.
Amfanin kwantar da hankali a cikin ƙwayar cuta yayin shan Diabeton ® MV bai dogara da fa'idodin da aka samu tare da maganin cututtukan ƙwayar cuta ba.

Pharmacokinetics

Damuwa
Bayan gudanar da baki, gliclazide yana cikin komai. Yawan taro na gliclazide a cikin plasma jini yana ƙaruwa a hankali a cikin awanni 6 na farko, ana kula da matakin filayen daga 6 zuwa 12 sa'o'i. Musamman daidaiku sun yi karanci.
Cin abinci baya shafar yawan ko yawan sha na gliclazide.

Rarraba
Aƙalla kusan kashi 95% na glycazide suna ɗaure zuwa garkuwar plasma. Ofimar rarraba shine kusan lita 30.Shan magungunan masu ciwon sukari ® MV a cikin kashi 60 MG sau ɗaya a rana yana tabbatar da kiyaye ingantaccen taro na glycazide a cikin jini na sama da awanni 24.

Tsarin rayuwa
Gliclazide yana cikin metabolized da farko a cikin hanta. Babu ƙwayoyin metabolites mai aiki a cikin jini.

Kiwo
Glyclazide yana daɗaɗɗen ƙwayoyin kodan: an fitar da isarwar a cikin hanyar metabolites, ƙasa da 1% an cire ta da kodan ba canzawa. Rabin rayuwar gliclazide shine matsakaita na awanni 12 zuwa 20.

Rashin layi
Dangantaka tsakanin kashi da aka ɗauka (har zuwa 120 MG) da kuma yanki a ƙarƙashin kantin magani "maida hankali - lokaci" shine layi.

Al'umma na Musamman
Tsofaffi mutane
A cikin tsofaffi, babu canje-canje masu mahimmanci a cikin sigogi na pharmacokinetic.

HANKALI GA YANZU

Nau'in nau'in ciwon sukari na 2 da ƙarancin ingantaccen aikin maganin abinci, aikin jiki da asarar nauyi.
Yin rigakafin rikice-rikice na ciwon sukari mellitus: rage haɗarin microvascular (nephropathy, retinopathy) da rikice-rikice na macrovascular (infarction na myocardial, rauni) a cikin marasa lafiya da nau'in ciwon sukari na 2 na mellitus ta hanyar sarrafa glycemic mai ƙarfi.

hypersensitivity to gliclazide, sauran abubuwan da ake amfani da su na sulfonylurea, sulfonamides ko kuma ga wadanda suka sha daga cikin magungunan,
nau'in ciwon sukari guda 1
fida mai fama da ciwon sukari,
mai girma na koda ko hepatic kasawa (a cikin waɗannan halayen, ana bada shawara don amfani da insulin),
shan miconazole (duba sashin "hulɗa tare da wasu kwayoyi"),
ciki da lactation (duba sashin "Cutar ciki da lokacin lactation"),
shekaru zuwa shekaru 18.

Saboda gaskiyar cewa shirya ya ƙunshi lactose, Diabeton MV ba a ba da shawarar ga marasa lafiya da rashin haƙuri na lactose, galactosemia, glucose-galactose malabsorption.
Ba'a ba da shawarar a yi amfani dashi a hade tare da phenylbutazone ko danazole (duba sashin "hulɗa tare da wasu kwayoyi").

Tare da kulawa
Tsofaffi, rashin daidaituwa da / ko abinci mara daidaituwa, raunin glucose-6-phosphate dehydrogenase, cututtukan cuta mai mahimmanci na tsarin zuciya, cututtukan zuciya, adrenal ko pituitary insufficiency, renal da / ko gazawar hanta, tsawaitawa tare da glucocorticosteroids (GCS), shan giya.

CIGABA DA CIKIN CIKIN SAUKI KYAUTA

Ciki
Babu gwaninta tare da gliclazide yayin daukar ciki. Bayanai game da amfani da wasu abubuwan da ake amfani da su na sulfonylurea yayin daukar ciki suna iyakatacce.
A cikin bincike a kan dabbobi na dakin gwaje-gwaje, ba a gano tasirin teratogenic na gliclazide ba.
Don rage haɗarin rikice-rikice na haihuwar haihuwa, ingantaccen iko (magani mai dacewa) na ciwon sukari mellitus ya zama dole. Ba'a amfani da magungunan maganin ƙwayar cuta na baka a lokacin daukar ciki.
Insulin shine magani na zabi don maganin cututtukan siga a cikin mata masu juna biyu.
An bada shawara don maye gurbin ci na maganin ƙwayoyin cuta hypoglycemic na baki tare da maganin insulin duka a cikin yanayin da aka shirya yin ciki, kuma idan ciki ya faru yayin shan maganin.

Rashin shayarwa
Yin la'akari da rashin bayanai game da cin gliclazide a cikin madara da kuma hadarin haɓaka ƙarancin ƙwayar cuta, an shayar da jarirai nono yayin maganin ƙwayoyi.

KYAUTA DA ADDU'A

DARASI NA YI AMFANI DA KAWAI DON SAURAN ADDU'A.

Ya kamata a dauki maganin da aka bashi shawarar a baki, sau 1 a rana, zai fi dacewa yayin karin kumallo.
Girman yau da kullun na iya zama 30-120 mg (1 /₂ -2 Allunan) a kashi daya.
An ba da shawarar haɗiye kwamfutar hannu ko rabin kwamfutar hannu gaba ɗaya ba tare da tauna ko murƙushewa ba.
Idan ka rasa magunguna ɗaya ko sama ɗaya, baza ku iya ɗaukar babbar magani a kashi na gaba ba, yakamata ku ɗauki kashi da kuka ɓace gobe.
Kamar yadda yake tare da sauran magungunan hypoglycemic, ana buƙatar zaɓi kashi na miyagun ƙwayoyi a kowane yanayi daban-daban, gwargwadon tattarawar glucose jini da HbA1c.

Farkon kashi
Yankin da aka bada shawarar farko (gami da ga tsofaffi marasa lafiya, ≥ 65 shekara) shine 30 MG kowace rana (1 /₂ kwayoyin hana daukar ciki).
Game da isasshen iko, ana iya amfani da magani a cikin wannan adadin don maganin kulawa. Tare da rashin isasshen iko na glycemic, ana iya ƙara adadin kwayoyi na yau da kullun zuwa 60, 90 ko 120 MG.
Increaseara yawan kashi yana yiwuwa ba da farko ba bayan watan 1 na maganin ƙwaƙwalwar ƙwayar cuta a ƙayyadadden maganin da aka tsara a baya. Banda shi ne marasa lafiya waɗanda ba su raguwa da glucose din jini ba bayan makonni 2 na maganin. A irin waɗannan halayen, ana iya ƙara kashi 2 makonni biyu bayan farawar gudanarwa.
Matsakaicin shawarar da aka bayar na yau da kullun na miyagun ƙwayoyi shine 120 MG.
1 kwamfutar hannu na miyagun ƙwayoyi masu ciwon sukari tablets Allunan MV tare da ingantaccen saki na 60 MG daidai yake da Allunan 2 na masu ciwon sukari tablets Allunan kwafi tare da sakewa na 30 MG Kasancewar daraja a kan allunan kwayar mg 60 (60 mg) zata baka damar raba kwamfutar hannu kuma ka dauki kashi 30 a rana 30 na mg (1 /₂ Allunan 60 mg), kuma idan ya cancanta 90 MG (1 da 1 /₂ Allunan 60 MG).

Sauyawa daga shan magungunan masu ciwon sukari ® Allunan na 80 MG zuwa magungunan masu ciwon sukari tablets Allunan MV tare da ingantaccen sakin 60 MG 1 kwamfutar hannu na miyagun ƙwayoyi Diabeton ® 80 MG za a iya maye gurbin 1 /₂ Allunan tare da ingantaccen saki Diabeton ® MV 60 MG. Lokacin canja wurin marasa lafiya daga Diabeton ® 80 MG zuwa Diabeton ® MV, ana bada shawarar kulawa da hankali glycemic.

Canja daga shan wani nau'in magani na hypoglycemic zuwa magungunan Diabeton ® Allunan MV tare da sakewa na 60 mg
Magungunan Diabeton ® MV Allunan tare da sakewa na 60 MG za'a iya amfani dashi a maimakon wani magani na hypoglycemic don maganin baka. Lokacin canja wurin marasa lafiya da ke karɓar wasu magunguna na hypoglycemic don sarrafawa na baka zuwa Diabeton ® MV, yakamata a yi la'akari da kashi da rabin rayuwa. A matsayinka na mai mulkin, ba a bukatar lokacin juyawa. A kashi na farko yakamata ya zama mil 30 sannan sannan akasashi ya danganta da maida hankali kan glucose na jini.
Lokacin da aka maye gurbin Diabeton ® MV tare da abubuwanda suka samo asali na sulfonylurea tare da dogon kawar rabin rayuwa don guje wa hauhawar jini wanda ya haifar da tasirin mahaɗin jini biyu, zaku iya dakatar da shan su na kwanaki da yawa. Kashi na farko na magani Diabeton ® MV shima 30 MG ne (1 /₂ Allunan 60 MG) kuma, idan ya cancanta, ana iya karuwa nan gaba, kamar yadda aka bayyana a sama.

Hada kai tare da wani magani na hypoglycemic
Ana iya amfani da ciwon sukari ® MV a hade tare da biguanidins, inhibitors alpha-glucosidase ko insulin. Tare da rashin isasshen iko na glycemic, ƙarin insulin far ya kamata a wajabta shi tare da saka idanu na likita.

Tsofaffi marasa lafiya
Ba a buƙatar gyaran fuska don marasa lafiya waɗanda suka girmi shekaru 65 ba.

Marasa lafiya tare da gazawar koda
Sakamakon binciken asibiti ya nuna cewa ba a buƙatar daidaita sigar magani a cikin marasa lafiya tare da gazawar ƙarancin ƙayyadadden matsakaici zuwa matsakaici. Ana ba da shawarar rufe aikin likita.

Marasa lafiya a Hadarin Hypoglycemia
A cikin marasa lafiya da ke cikin haɗarin haɓakar hypoglycemia (ƙarancin abinci mai gina jiki ko rashin daidaituwa, mummunan cuta ko raunin endocrine - damuwa da rashin ƙarfi, hypothyroidism, soke glucocorticosteroids (GCS) bayan tsawaita amfani da / ko gudanarwa a cikin manyan allurai, cututtukan zuciya mai tsanani. tsarin jijiyoyin jiki - mummunan cututtukan zuciya, mummunan carotid arteriosclerosis, atherosclerosis na kowa), ana bada shawara don amfani da mafi ƙarancin kashi (30 MG) na shirya ata Diabeton ® MV.

Yin rigakafin rikicewar cututtukan siga
Don cimma nasarar sarrafa glycemic mai ƙarfi, a hankali zaku iya ƙara yawan kwayar cutar Diabeton ® MV zuwa 120 mg / rana ban da abinci da motsa jiki don cimma burin HbA1c. Lura da hadarin kamuwa da cututtukan jini. Bugu da ƙari, sauran magungunan hypoglycemic, alal misali, metformin, inhibitor na alpha-glucosidase, mai thiazolidinedione na insulin, ana iya ƙara shi zuwa far.

Yara da matasa da ke ƙasa da shekara 18.
Ba a samun bayanai game da inganci da amincin miyagun ƙwayoyi a cikin yara da matasa masu shekaru 18 ba.

ADDU'AR SAUKI
Ganin ƙwarewa tare da gliclazide, ya kamata ku tuna game da yiwuwar haɓaka sakamako masu illa.

Hypoglycemia
Kamar sauran magunguna na ƙungiyar sulfonylurea, da keɓaɓɓen ƙwayar cutar sankara ® MV na iya haifar da ciwon sikila idan yanayin rashin daidaituwa ne na abinci kuma musamman idan aka rasa cin abincin. Bayyanar alamun alamomin hypoglycemia: ciwon kai, matsananciyar yunwar, tashin zuciya, matsananciyar ƙarfi, yawan gajiya, tashin hankali, tashin hankali, ragi, raguwar tashin hankali, rashi, damuwa, hangen nesa da magana, aphasia, rawar jiki, paresis, asarar iko da kai. , jin rashin taimako, tsinkaye mara kyau, buguwa, kasala, rashi, bradycardia, hanji, numfashi mara nauyi, nutsuwa, asarar sani tare da yuwuwar ci gaba, na rashin nasara, har zuwa mutuwa.
Hakanan za'a iya lura da halayen Andrenergic: ƙara yawan zufa, fata "m", damuwa, tachycardia, haɓakar jini, palpitations, arrhythmia, da angina pectoris.

A matsayinka na mai mulkin, ana dakatar da alamun hypoglycemia ta hanyar shan carbohydrates (sukari). Shan masu zaki shine bashi da amfani. A cikin asalin wasu hanyoyin da aka samo asali na maganin sulfonylurea, an lura da komawar hypoglycemia bayan nasarar da ta samu.

A cikin tsananin rauni ko tsawan jini, ana nuna kulawa ta gaggawa akan likita, watakila tare da asibiti, koda kuwa akwai wani tasiri daga shan carbohydrates.

Sauran sakamako masu illa

Daga cikin jijiyoyin mahaifa: ciwon ciki, tashin zuciya, amai, gudawa, maƙarƙashiya. Shan magungunan yayin karin kumallo yana hana waɗannan bayyanar cututtuka ko rage su.

Wadannan sakamako masu illa ba su da yawa:

A bangare na fata da kasusuwa na jiki: kurji, itching, urticaria, Quincke ta edema, erythema, maculopapular fitsari, m halayen (irin su Stevens-Jones ciwo da guba epidermal necrolysis).

Daga gabobin hemopoietic da tsarin lymphatic: rikicewar bashin jini (anaemia, leukopenia, thrombocytopenia, granulocytopenia) suna da wuya. A matsayinka na mai mulkin, waɗannan abubuwan mamaki ana iya juyawa idan an daina maganin jiyya.

A ɓangaren hanta da ƙwayar biliary: haɓaka aikin enzymes "hanta" (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (lokuta da kebe). Idan cutar yolestice ta faru, yakamata a dakatar da maganin.

Wadannan abubuwan ba za su zama masu sakewa ba idan an daina maganin su.

Daga gefen gabar hangen nesa: rikicewar gani na yau da kullun na iya faruwa saboda canji a cikin taro na jini, musamman a farkon farawa.

Sakamakon sakamako masu illa ga abubuwan da aka samo asali na sulfonylurea: kamar yadda yake tare da sauran abubuwanda suka haifar, an lura da sakamako masu zuwa: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, vasculitis rashin lafiyan, hyponatremia. An sami karuwa a cikin ayyukan "hanta" enzymes, hanta aiki na hanta (alal misali, tare da haɓakar cholestasis da jaundice) da hepatitis, bayyanuwar ta ragu akan lokaci bayan dakatar da shirye-shiryen sulfonylurea, amma a wasu halayen haifar da gazawar hanta ga haɗari.

An gano tasirin sakamako a cikin gwaji na asibiti
A cikin binciken ADVANCE, an sami bambanci kaɗan a cikin tasirin mummunan yanayin haɗari tsakanin rukunin marasa lafiya biyu. Babu sabon bayanan aminci da aka karba. Smallaramin adadin marasa lafiya suna da cutar rashin ƙarfi na jini, amma ɗaukacin abin da ya faru na rashin ƙarfi zuwa ƙasa ya ragu. Halin da ke faruwa a cikin ƙwayar cuta mai ƙarfi ya kasance sama da ƙungiyar kula da glycemic misali. Yawancin bangarori na hypoglycemia a cikin rukunin glycemic intensive an lura da su ta fuskar tsarin kwantar da hankali na insulin.

SAURARA
Idan akwai abubuwan da ake amfani da su na asalin abubuwan sulfonylurea, cututtukan jini na iya bunkasa.
Idan kun sami alamun bayyanar cututtuka na hypoglycemia ba tare da tsinkaye mara kyau ko alamun cututtukan jijiyoyin jiki, ya kamata ku ƙara yawan ƙwayar carbohydrates tare da abinci, rage yawan ƙwayoyi da / ko canza abincin. Kusa da likita kwantar da hankali game da yanayin mai haƙuri ya kamata ya ci gaba har sai an sami tabbacin cewa babu abin da ke barazana ga lafiyarsa. Wataƙila haɓaka yanayi mai rauni, tare da coma, tarko ko wasu rikicewar jijiyoyin jiki. Idan irin waɗannan bayyanar cututtuka sun bayyana, kulawar likita ta gaggawa da asibiti a cikin gaggawa suna da mahimmanci.
Game da cutar rashin ruwa a cikin jini ko kuma idan an yi zargin, ana yin allurar cikin ciki tare da 50 ml na maganin 20-30% na dextrose (glucose). To, ana samar da maganin 10% na dextrose da aka sauke don kula da yawan hawan glucose na jini sama da 1 g / L. Dole ne a yi taka tsantsan da lura da matakan glucose na jini da saka idanu akan mara lafiya aƙalla awanni 48 masu zuwa. Bayan wannan lokacin, dangane da yanayin haƙuri, likitan halartar ya yanke shawara game da buƙatar ƙarin sa ido. Dialysis ba shi da tasiri saboda ƙayyadadden ikon ɗaukar nauyin gliclazide zuwa ƙwayoyin plasma.

CIKIN SAUKI DA SAURAN LAFIYA

1) Magunguna da abubuwa masu haɓaka haɗarin hauhawar jini:
(haɓaka sakamakon gliclazide)

Abubuwan haɗin gwiwa
- Miconazole (tare da gudanarwa na tsari da kuma lokacin amfani da gel a kan mucosa na bakin): haɓaka tasirin hypoglycemic na gliclazide (hypoglycemia na iya haɓaka har zuwa coma).

Ba da shawarar haɗuwa ba
- Phenylbutazone (gudanarwa na tsari): haɓaka tasirin sakamako na abubuwan da aka samo asali na maganin sulfonylurea (yana kawar da su daga sadarwa tare da sunadaran plasma da / ko yana rage jinkirin fitar da su daga jiki).
Zai fi kyau a yi amfani da wani magani na kashe kumburi. Idan phenylbutazone ya zama dole, ya kamata a faɗakar da mai haƙuri game da buƙatar sarrafa glycemic. Idan ya cancanta, yakamata a daidaita sashi na maganin Diabeton ® MV a yayin da yake shan phenylbutazone da kuma bayan sa.
- Ethanol : haɓaka hypoglycemia, yana hana halayen ramuwar gayya, na iya ba da gudummawa ga haɓakar ƙwaƙwalwar ƙwayar cuta. Wajibi ne a ƙi shan magunguna, waɗanda suka haɗa da ethanol da barasa.

Kariya
Glyclazide a hade tare da wasu kwayoyi: sauran wakilai na hypoglycemic (insulin, acarbose, metformin, thiazolidinidiones, dipeptidyl peptidase-4 inhibitors, GLP-1 agonist), wakilin tarewa na beta-adrenergic tarewa, fluconazole, angiotensin-antiplatelet inhibitors, caprimin,₂masu karɓa -histamine, masu hanawa gas na gas na oxidase, sulfonamides, clarithromycin da magungunan anti-mai kumburi) yana haɗuwa tare da haɓaka sakamako na hypoglycemic da haɗarin hypoglycemia.

2) Magungunan da ke haɓaka glucose na jini:
(raunana sakamakon gliclazide)

- Danazole: yana da sakamako masu ciwon sukari. Idan shan wannan magani ya zama dole, an shawarci mai haƙuri ya lura da glucose na jini a hankali. Idan ya cancanta, haɗin gwiwa na magunguna, ana ba da shawarar cewa za a zaɓi kashi na wakili na hypoglycemic duka yayin gwamnatin danazol da kuma bayan an cire ta.

Kariya
- Chlorpromazine (antipsychotic) : a cikin allurai masu yawa (fiye da 100 MG kowace rana) yana kara yawan glucose a cikin jini, yana rage yawan asirin insulin.
Anyi shawarar kulawa da hankali glycemic. Idan ya cancanta, haɗin gwiwa na magunguna, ana ba da shawarar cewa za a zaɓi ƙarin kashi na hypoglycemic wakili, duka biyu a lokacin gudanar da maganin rigakafi da kuma bayan an cire shi.
- GKS (Tsarin tsari da aikace-aikacen gida: intraarticular, fata, gudanarwar hanji) da tetracosactide: haɓakar taro na jini tare da yiwuwar ci gaban ketoacidosis (raguwa cikin haƙuri ga carbohydrates). Ana ba da shawarar kula da hankali sosai, musamman a farkon jiyya. Idan ya zama dole don shan kwayoyi tare, za a buƙaci daidaitawar kashi na wakilin hypoglycemic duka yayin gudanar da GCS da kuma bayan an cire su.
- Ritodrin, salbutamol, terbutaline (gudanarwa na ciki): beta-2 adrenergic agonists yana ƙara yawan haɗarin glucose na jini.
Dole ne a saka kulawa ta musamman akan mahimmancin sarrafa kwayar cutar glycemic. Idan ya cancanta, ana bada shawara don canja wurin mai haƙuri zuwa maganin insulin.

3) Haɗe-haɗe da za'ayi la'akari dasu

- Anticoagulants (misali warfarin)
Abubuwan da keɓaɓɓe na sulfonylureas na iya haɓaka tasirin maganin anticoagulants lokacin ɗauka tare. Ana iya buƙatar daidaita sakin Anticoagulant.

LITTAFIN KWARAI

Hypoglycemia
Lokacin ɗaukar magungunan sulfonylurea, ciki har da gliclazide, hypoglycemia na iya haɓakawa, a wasu yanayi a cikin mummunan yanayi da tsawan yanayi, ana buƙatar asibiti da kulawa da jijiyoyin maganin rage ƙwaƙwalwar ƙwayar cuta a cikin kwanakin da yawa (duba sashin "Abubuwan sakamako").
Za'a iya ba da magani ga wajan marasa lafiya waɗanda abincinsu na yau da kullun kuma sun haɗa da karin kumallo. Yana da mahimmanci a kula da isasshen ƙwayar carbohydrates tare da abinci, tun da haɗarin haɓakar hauhawar jini yana ƙaruwa tare da abinci mai daidaitacce ko rashin daidaituwa, daidai lokacin da cinye abincin da ke da talauci a cikin carbohydrates.
Hypoglycemia sau da yawa yana haɓaka tare da rage cin abinci mai kalori, bayan tsawanta ko motsa jiki mai ƙarfi, bayan shan giya, ko lokacin shan magunguna na hypoglycemic da yawa a lokaci guda.
Yawanci, alamun hypoglycemia yana ɓacewa bayan cin abinci mai abinci mai kyau a cikin carbohydrates (kamar sukari). Ya kamata a ɗauka cikin tunanin cewa shan masu zaƙi ba zai taimaka wajen kawar da alamun cututtukan zuciya ba. Kwarewar amfani da wasu abubuwan da ake amfani da su na sulfonylurea suna nuna cewa hypoglycemia na iya dawowa duk da tasirin farko na wannan yanayin. Idan yanayin bayyanar cututtuka na hypoglycemic an furta ko suna daɗewa, har ma a yanayin haɓaka ɗan lokaci bayan cin abinci mai cike da carbohydrates, kulawa ta gaggawa ta zama tilas, har zuwa asibiti.
Don guje wa ci gaban hypoglycemia, zaɓin zaɓi na mutum da hankali da kuma hanyoyin yin magani ya zama dole, kazalika da samar wa mara lafiya cikakken bayani game da magani.

Increasedarin haɗarin hauhawar jini na iya faruwa a waɗannan lamari:

ƙi ko rashin haƙuri na marasa lafiya (musamman tsofaffi) don bi abubuwan da likitocin suka rubuta don duba yanayinsa,
karancin abinci mai gina jiki, rashin abinci mai gina jiki, azumi da kuma rage cin abincin,
rashin daidaituwa tsakanin aiki na jiki da kuma adadin carbohydrates,
na gazawar
mai tsanani hanta
yawan shan magani na masu ciwon sukari ® MV,
wasu rikice-rikice na endocrine: cutar ta thyroid, pituitary da adrenal insufficiency,
Lokaci guda na amfani da wasu magunguna (duba sashe "hulɗa tare da wasu kwayoyi").

Renal da hanta ta gaza
A cikin marasa lafiya da ke fama da hepatic da / ko gazawar ƙoshin koda, ƙwayar magunguna da / ko kaddarorin magungunan gliclazide na iya canzawa. Halin hypoglycemia wanda ke tasowa a cikin irin waɗannan marasa lafiya na iya zama daɗewa sosai, a cikin irin waɗannan halayen, likita na dacewa ya zama dole.

Bayanai mara haƙuri
Wajibi ne a sanar da mara lafiya, da kuma dangin sa, game da hadarin kamuwa da cutar sankarar mahaifa, alamunta da kuma yanayin da ke kawo ci gabanta. Dole ne a sanar da mara lafiya game da haɗarin haɗari da fa'idojin magani da aka gabatar.
Marasa lafiya yana buƙatar bayyana mahimmancin cin abinci, buƙatar motsa jiki na yau da kullun da saka idanu akan yawan haɗuwar glucose jini.

Rashin iya sarrafa glycemic
Gudanar da cutar ta glycemic a cikin marasa lafiya da ke karɓar maganin cututtukan cututtukan jini na iya zama mai rauni a cikin waɗannan lamurran masu zuwa: zazzabi, rauni, cututtuka na gaba, ko babban tiyata. Tare da waɗannan yanayin, yana iya zama mahimmanci don dakatar da jiyya tare da miyagun ƙwayoyi Diabeton ® MV kuma a tsara maganin insulin.
A cikin marasa lafiya da yawa, tasirin wakilai na hypoglycemic na bakin mutum, gami da gliclazide, yana jin daɗin raguwa bayan dogon lokaci na jiyya. Wannan tasiri na iya zama saboda ci gaban cutar da raguwa a cikin maganin warkewa da magunguna. An san wannan sabon abu a matsayin juriya na miyagun ƙwayoyi, wanda dole ne a bambanta shi da na farko, wanda magani ba ya ba da sakamako na asibiti a cikin wa’adin farko. Kafin bincikar mai haƙuri tare da juriya na miyagun ƙwayoyi, ya zama dole don kimanta ƙimar zaɓi na zaɓi da kuma yardawar haƙuri tare da abincin da aka tsara.

Gwaje-gwaje na Lab
Don tantance iko na glycemic, ana bada shawarar dagewa na yau da kullun na jinin glucose jini da na jini HbA1c na yau da kullun.
Bugu da kari, yana da kyau a rika gudanar da aikin kai-da-kai game da yawan kwantar da hankali na glucose na jini.
Abubuwan da ke cikin Sulfonylurea na iya haifar da cutar haemolytic a cikin marasa lafiya da raunin glucose-6-phosphate dehydrogenase. Tunda gliclazide wani abu ne wanda ya samo asali na sulfonylurea, dole ne a kula da shi yayin gudanar da shi ga marasa lafiya da raunin glucose-6-phosphate dehydrogenase.
Zai yiwu a kimanta yiwuwar rubuta kwayar cutar ƙwaƙwalwar ƙwayar cuta ta wata ƙungiyar.

INFLUEN ON IKON ZUWA KARFIN SHAWARA DA KUDURAI
Dangane da yiwuwar haɓakar hypoglycemia tare da amfani da miyagun ƙwayoyi Diabeton ® MV, marasa lafiya ya kamata su san alamun hypoglycemia kuma ya kamata suyi hankali lokacin tuki motocin ko yin aikin da ke buƙatar babban halayyar halayen jiki da na tunani, musamman a farkon farfaɗo.

MAGANIN YI
60 mg gyara allunan saki
Allunan 30 a cikin kumburi (PVC / Al), blister 1 ko 2 tare da umarnin amfani da likita a cikin kwali.
Lokacin da marufi (marufi) a kamfanin Rasha LLC Serdix:
Allunan 30 a cikin kumburi (PVC / Al), blister 1 ko 2 tare da umarnin amfani da likita a cikin kwali.
Allunan 15 a cikin kumburi (PVC / Al), blister 2 ko 4 tare da umarnin don amfani da likita a cikin kwali.
Ta hanyar samarwa a kamfanin Rasha na LLC Serdix
Allunan guda 15 a cikin sikirin na PVC / Al. Don blister 2 ko 4 tare da umarnin amfani da magani a cikin fakitin kwali.

HUKUNCIN SAURARA
Ba a buƙatar yanayi na ajiya na musamman.
Ayi nesa da isar yara.

RAYUWAR SHI
Shekaru 2 Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

HANYAR BAYANIN
Da takardar sayan magani.

MANUFACTURER
Labs Masana'antu, Faransa
Serdix LLC, Rasha

Takaddun rajista da aka bayar daga Cibiyar Nazari ta Servier Laboratories, Faransa;

"Laboratories Servier masana'antu":
905, Saran babbar hanyar, 45520 Gidey, Faransa
905, hanya de Saran, 45520 Gidy, Faransa

Ga duk tambayoyin, tuntuɓi ofishin Wakilin Hukumar JSC “Servier Laboratory”.

Wakilcin JSC “Laboratory Servier”:
115054, Moscow, Paveletskaya pl. d.2, shafi 3

A cikin batun kunshin da / ko marufi / a cikin samarwa a LLC Serdiks, Rasha
Serdix LLC:
Rasha, Moscow

Diabeton MV: umarnin don amfani (sashi da hanyar)

Ana shan maganin a baki, sau ɗaya a rana (zai fi dacewa yayin karin kumallo). An ba da shawarar yin nika ko tauna kwamfutar hannu.

Yawan kowace rana na ciwon sukari MV ya bambanta daga kashi 30 zuwa 120 a cikin kashi ɗaya. Idan ka rasa kwana ɗaya ko fiye na magani, ba za ku iya ƙara yawan kashi ba a kashi na gaba.

An zaɓi kashi na miyagun ƙwayoyi daban-daban yin la'akari da alamomi kamar haɗuwar glucose a cikin jini da kuma matakin glycogemoglobin (HbA1c).

A farkon jiyya, an wajabta masu ciwon sukari MV 30 MG a kowace rana (ciki har da marasa lafiya tsofaffi shekaru 65 da haihuwa). Tare da isasshen sarrafawa, ana iya amfani da gliclazide a matsayin maganin kulawa. Game da rashin daidaitaccen iko na glycemic, ana iya ƙara yawan kashi (akai-akai) zuwa 60 MG, 90 MG ko 120 MG kowace rana.

Za'a iya ƙaruwa kashi ɗaya bayan magani na wata ɗaya tare da gliclazide a cikin maganin da aka wajabta a baya, ban da waɗancan marasa lafiya waɗanda matakan glucose na jini bai ragu ba bayan makonni 2 na amfani da miyagun ƙwayoyi. Irin waɗannan marasa lafiya na iya ƙara yawan kashi bayan makonni 2 na maganin.

Matsakaicin adadin Diabeton MV shine 120 MG kowace rana.

Lokacin canzawa daga miyagun ƙwayoyi na Diabeton (80 MG na gliclazide) zuwa Diabeton MV, ana canza kwamfutar hannu guda ɗaya na Diabeton zuwa rabin kwamfutar hannu na Diabeton MV 60 MG. Juyin mulkin yana gudana ne a ƙarƙashin kulawa da hankali na glycemic.

Ana iya ɗaukar cutar Diabeton MV a maimakon sauran wakilai na baka hypoglycemic. Lokacin canja wurin mai haƙuri, ana yin la'akari da adadin maganin da ake amfani dashi na hypoglycemic da rabin rayuwarsa. Yawancin lokaci ba lokacin da ake buƙata. Kashi na farko na ciwon sukari MV shine 30 MG kuma daga baya an sanya shi mai lamba gwargwadon matakin glucose a cikin jini.

Idan mai haƙuri ya ɗauki wasu abubuwan da ake amfani da su na sulfonylurea tare da dogon rabin rabin kawar, yana da mahimmanci don dakatar da jiyya don kwanaki da yawa kuma bayan hakan ya fara shan Diabeton MV (don hana hypoglycemia, wanda zai iya haifar da sakamakon ƙari na magungunan hypoglycemic biyu).

Za'a iya haɗa Gliclazide tare da masu hana alpha-glucosidase, insulin ko biguanidines.

Game da rashin isasshen kulawar glycemic, ana yin aikin insulin lokaci guda a karkashin kulawar likitanci.

Ga marasa lafiya waɗanda shekarunsu suka kai 65 da haihuwa, da kuma marasa lafiya tare da gazawar matsakaici zuwa ƙarancin ƙarancin koda, ba a buƙatar daidaita sashi.

A gaban contraindications na dangi, ana amfani da Diabeton MV a cikin mafi ƙarancin shawarar (30 MG kowace rana).

Side effects

tsarin narkewa: tashin zuciya, ciwon ciki, amai, maƙarƙashiya ko zawo (shan gliclazide yayin karin kumallo yana rage yiwuwar waɗannan alamun bayyanar),
hanta da kuma biliary fili: ƙara yawan hanta transaminase, lokuta ya zama ruwan dare - hepatitis (ana buƙatar dakatar da jiyya),
tsarin lymphatic da gabobin jini na jini: da wuya - leukopenia, anemia, granulocytopenia, thrombocytopenia (bacewa bayan dakatarwar da maganin),
fata da kitsen fata: itching fata, erythema, fitsari, urticaria, maculopapular fitsari, angioedema, bullo halayen,
gabobin azanci: rikicewar gani na yau da kullun saboda canje-canje a matakan glucose, musamman a farkon jiyya.

Yayin yin jiyya tare da masu ciwon sukari na MV, cututtukan jini na iya haɓaka, musamman tare da abinci na yau da kullun ko tsallake karin kumallo, abincin rana ko abincin dare. Bayyanar cututtukan cututtukan zuciya sune: tashin zuciya, matsananciyar yunwar, amai, ciwon kai, haushi, rage saurin kulawa, gajiya, tashin hankali, saurin rikicewa, tashin hankali, rikicewa, rawar jiki, jin rashin taimako, bacin rai, magana mara nauyi da hangen nesa, asarar iko da kai, bacin rai, paresis, tsinkaye mara kyau, rashi, aphasia, bradycardia, m numfashi, dizzness, rauni, nutsuwa, delirium, asarar sani, coma (har mutuwa). Hakanan halayen adrenergic na gaba zasu iya faruwa: damuwa, hyperhidrosis, tachycardia, palpitations, angina pectoris, ƙwayar fata, haɓakar jini da arrhythmia.

Yawancin lokaci, alamun cututtukan hypoglycemia an sami nasarar dakatar da shan sukari (carbohydrates). Masu zaki basu da inganci. Idan bayan nasarar nasarar hypoglycemia mai haƙuri ya ɗauki wasu abubuwan da ake amfani da su na sulfonylurea, komawa daga ciki na iya faruwa tare da maimaitawa. Game da batun tsawan jini ko tsananin damuwa, ana bada shawarar kulawa ta gaggawa (har zuwa asibiti), koda tare da sauƙin bayyanar cututtuka ta hanyar sarrafa kansa na carbohydrates.

Wasu lokuta miyagun ƙwayoyi na iya haifar da waɗannan sakamako masu illa a cikin dukkanin abubuwan da suka samo asali na sulfonylurea: hemolytic anemia, erythrocytopenia, pancytopenia, hyponatremia, agranulocytosis, rashin lafiyar vasculitis.

Umarni na musamman

Za a iya rubuta wa masu ciwon sukari MV kawai ga waɗanda ke fama da rashin tsallake abinci kuma koyaushe suna karin kumallo. Yana da mahimmanci a kiyaye wadataccen carbohydrates daga abinci kuma a guji abinci mara ƙanƙan da ke ciki. Hadarin hypoglycemia yana ƙaruwa a cikin waɗannan lambobin:

mai tsanani hanta
na gazawar
gaban wasu cututtukan endocrine (adrenal da pituitary insufficiency, cututtukan thyroid),
na yau da kullun da rashin abinci mai kyau, azumi, abinci tsallaka, canje-canje a tsarin abinci,
rashin daidaituwa tsakanin adadin carbohydrates kawota tare da abinci da aikin mutum,
amfani da wasu magunguna lokaci guda (duba sashin "hulɗa Drug"),
yawan yawa na gliclazide,
rashin iyawa ko ƙi mara haƙuri (musamman ma a cikin tsufa) don sarrafa yanayin kansa kuma bi umarnin likita.

Rashin rauni na sarrafa glycemic an yarda a cikin marasa lafiya da raunin da ya faru, manyan hanyoyin tiyata, cututtuka da zazzabi. A cikin waɗannan halayen, ana buƙatar karɓar Diabeton MV da gudanar da insulin.

A cikin marasa lafiya da yawa, tasiri na wakilai na hypoglycemic don maganin magana na iya raguwa na tsawon lokaci (abin da ake kira juriya da magungunan sakandare).

Hulɗa da ƙwayoyi

Tasirin gliclazide yana haɓaka tare da amfani da lokaci ɗaya tare da miconazole (an haɗa wannan haɗin, saboda yana iya haifar da ci gaba na ƙwaƙwalwar ƙwayar cuta), phenylbutazone da ethanol (an inganta tasirin hypoglycemic).

Saboda haɗarin hypoglycemia, ya kamata a yi amfani da Diabeton MV tare da taka tsantsan tare da magunguna masu zuwa: hypoglycemic jamiái (acarbose, insulin, thiazolidinediones, metformin, dipeptidyl peptidase-4 inhibitors), fluconazole, beta-adrenergic blocking jamiái, capon capin capin, magungunan rigakafin kumburi, anti-hurarru na H₂masu karɓa, masu hana inabin monoamine oxidase.

Sakamakon gliclazide yana raunana danazol (wannan ba a ba da shawarar wannan haɗin ba), chlorpromazine, glucocorticosteroids lokaci guda tare da tetracosactide da beta₂-adrenomimetik. Ana amfani da magungunan da aka jera tare da taka tsantsan kuma a ƙarƙashin ikon sarrafa glycemic.

Gliclazide na iya haɓaka tasirin cutar anticoagulants.

Misalin Diabeton MV sune Gliclazide MV, Gliclazide-AKOS, Gliclazide Canon, Gliclazide MV Pharmstandard, Golda MV, Glidiab, Gliklada, Diabetalong, Glidiab MV, Diabefarm, Glyclazid-SZ, Diabinax, Diabinax, Diabinax, Diabinax, Diabinax, Diabinax

Ra'ayoyi game da ciwon sukari MV

Marasa lafiya suna barin kyawawan sake dubawa game da Diabeton MV. Wannan magani ne na kwarai da gaske wanda ke taimakawa kula da matakan sukari na al'ada. Gliclazide da wuya ya haifar da rashin lafiyan halayen da sauran sakamako masu illa. Ya dace a sha kwayoyin, tunda ana tsara maganin yau da kullun don kashi ɗaya. Jiyya tare da masu ciwon sukari MV shine madadin da ya cancanta don maganin insulin.

Cons na miyagun ƙwayoyi, bisa ga marasa lafiya: buƙatar buƙatar ci gaba da amfani, ba za a iya ba wa yara ba, haɗarin hauhawar jini, hauhawar farashi, halayen mutum ga gliclazide.