Ciprofloxacin-AKOS Ciprofloxacin

Ido ya sauke 0.3% a cikin hanyar bayyananniyar maganin launin rawaya ko launin shuɗi.

Fitowa: gishiri mai disodium na ethylenediaminetetraacetic acid, mannitol ko mannitol, sodium acetate anhydrous ko ruwa uku, glacial acetic acid, benzalkonium chloride, ruwa d / da.

5 ml - kwalban dropper polyethylene (1) - fakitoci na kwali.

Form sashi

Ido ya fadi 0.3%

1 ml na bayani ya ƙunshi

abu mai aiki - ciprofloxacin hydrochloride (cikin sharuddan ciprofloxacin) - 3 MG,

magabata: benzalkonium chloride - 0.10 mg, disodium ededate (gishiri disodium na ethylenediaminetetraacetic acid, Trilon B), mannitol (mannitol), sodium acetate trihydrate (sodium acetic acid 3-aqueous), acid na glacia acid, ruwa don allura.

Share bayyanannu dan kadan yellowish ko dan kadan greenish mai rawaya

Kayan magunguna

Pharmacokinetics

Lokacin da aka yi amfani da shi a saman, ciprofloxacin ya shiga cikin kyallen idanu. Tana shiga cikin cornea da gaban ciki na ido, musamman idan murfin epithelial na cornea ya damu. Tare da lalacewar corneal, taro na ciprofloxacin da ke ciki yana da tasiri a kan yawancin abubuwanda ke haifar da cututtukan cututtukan mahaifa.

Bayan malami guda ɗaya, yawan ciprofloxacin a cikin danshi na ɗakin gaban idon ya kai bayan mintina 10 kuma shine 100 isg / ml. Matsakaicin ɗaukar Cmax a cikin danshi na ɗakin kwana bayan 1 h shine 190 μg / ml. Bayan sa'o'i 2, maida hankali kan ƙwayar ya fara raguwa, yayin da tasirin maganin ƙwaƙwalwa a cikin kyallen na cornea yana zuwa awa 6, a cikin danshi na ɗakin kwana - har zuwa 4 hours.

Bayan instillation, tsarin shan maganin yana yiwuwa. Tare da Topical aikace-aikace na ido saukad da naproprololoacin 4 sau / rana a duka idanuna don 7 kwanaki, da matsakaici taro na ciprofloxacin a cikin jini jini kasa da 2-2.5 ng / ml, matsakaicin maida hankali ne kasa da 5 ng / ml. Lokacin da aka yi amfani da shi a sama, T1 / 2 daga plasma shine sa'o'i 4-5. Magungunan suna kwance da kodan ba su canzawa - har zuwa 50%, kuma a cikin nau'ikan metabolites - har zuwa 10%, ta cikin hanji - kusan 15%. Wasu daga cikin magungunan an keɓance su cikin madara.

Pharmacodynamics

Babban wakilin maganin rigakafi mai mahimmanci daga rukuni na fluoroquinolones (wani yanki na monofluoroquinolones) don amfani da Topical a cikin maganin ophthalmology.

Yana hana kwayar halittar DNA ƙirar ƙwayar cuta (topoisomerases II da IV, alhakin aiwatar da supercoiling na chromosomal DNA a kusa da makaman nukiliya RNA, wanda ya zama dole don karanta bayanan kwayoyin), ya lalata kwayar halittar DNA, haɓakar ƙwayoyin cuta da rarrabuwa, yana haifar da canje-canjen ƙwayoyin cuta (ciki har da bangon sel da membranes) da saurin mutuwar kwayar halitta.

Yana aikata ƙwayoyin cuta akan kwayoyin gram-mara kyau yayin hutawa da rarrabuwa (tunda yana shafar ba kawai DNA goge ba, har ma yana haifar da ƙirar bangon tantanin halitta), da ƙananan ƙwayoyin gram-tabbatacce ne kawai yayin lokacin rarrabuwa. Theara yawan yanayin bangon ƙwayar cuta.

Toarancin mai guba ga ƙwayoyin macroorganism an yi bayanin su ta hanyar rashin ƙwayar DNA a cikin su. Yayin shan ciprofloxacin, babu wani ci gaban layi daya na tsayayya da sauran ƙwayoyin rigakafi waɗanda ba sa cikin rukunin masu hana ƙyalli, wanda ke ba da tasiri sosai ga ƙwayoyin cuta waɗanda ke tsayayya da aminoglycosides, penicillins, cephalosporins, tetracyclines da sauran wasu ƙwayoyin rigakafi.

M ga ciprofloxacin: gram-aerobic kwayoyin cuta: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii. Yersinia spp.), Sauran gram korafe ƙwayoyin cuta (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), wasu kwayoyin cutar cikin jikin kwayar cutar - Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tarin fuka, Mycobacterium kansasii, Corynebacterium diphtheriae,

Gram-tabbatacce kwayoyin aerobic: Staphylococcus spp.(Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Putogenes mai ƙarfi da ƙarfi, ƙarfi daga ciki).

Yawancin methicillin-resistant staphylococci suma suna iya jure ciprofloxacin.

Saurin hankali Kwayar cutar huda ciki, Enterococcus faecalis, Avcobacterium (located intracellularly) - matsakaici (ana buƙatar mai da hankali sosai don murƙushe su).

Yin tsayayya da miyagun ƙwayoyi: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. M da Pallidum treponema.

Resistance na ciprofloxacin yana haɓaka sannu a hankali, saboda, a gefe guda, bayan aikin ciprofloxacin babu kusan ƙwayoyin cuta, kuma a gefe guda, ƙwayoyin ƙwayoyin cuta basu da wani enzymes da ke lalata shi. Magungunan ba shi da guba.

Alamu don amfani

Cututtukan ido da na kumburi da ke haifar da ƙwayoyin cuta daga ƙwayar cuta:

- m da subacute conjunctivitis

- cututtukan ƙwayar cuta na ƙwayar cuta

- Cutar raunin ido bayan raunin da ya faru ko jikkunan kasashen waje

Yin rigakafi da lura da rikice-rikice masu rauni a cikin raunin ido da kayan aikinsa (haɗe da bayan cire jikin wata ƙasa daga cornea, conjunctiva, bayan bayyanuwa ga sinadarai ko hanyoyin jiki) da kuma yayin gudanar da aiki a kan ƙwallon ido (pre-da postoperative rigakafin kamuwa da cuta a cikin tiyata ophthalmic).

Hanyar aikace-aikaceda allurai

Gida 1-2 saukad da cikin jakar haɗin ido na abin da ya shafa. Mitar shigarwa ya dogara da tsananin girman aikin kumburi.

Idan mai laushi zuwa kamuwa da cuta mai raɗaɗi na matsakaici, ana saukad da 1-2 cikin kwalin ido wanda ya shafa (ko idanun biyu) kowane awanni 4, kuma cikin matsanancin ƙwayar cuta, 2 saukad kowace awa. Bayan haɓaka, ana rage kashi da yawan shigarwa.

A cikin cututtukan ƙwayar cuta mai saurin kamuwa da cuta, mai sauƙi, scaly da cututtukan cututtukan zuciya - 4-8 sau / rana, gwargwadon yanayin zafin kumburi.

Tare da keratitis - 1 sauke akalla sau 6 / rana.

Tare da lalacewar cornea wanda Pseudomonas aeruginosa ya haifar, 1 sauke sau akalla sau 8-12 / rana.

Tare da uveitis na baya, ana sanya magani a 1 sauke sau 8-12 sau / rana. A cikin tsananin dacryocystitis da canaliculitis - 1 sauke sau 6-12 sau / rana, a na kullum - sau 4-8 / rana.

Idan akwai cututtukan ƙwayar ƙwayar cuta a cikin ƙwayar cuta: a rana ta farko - kowane mintina 15 na tsawon awanni 6, to 1 sauke kowane minti 30 a cikin lokutan farkawa, rana ta biyu - 1 sauke kowane awa a lokacin farkawa, daga kwanaki 3 zuwa 14 - 1 sauke kowane Awanni 4 yayin awowi na farkawa.

Don rigakafin kamuwa da cuta na sakandare tare da raunin ido da kayan aiki - 1 sauke sau 4-8 sau / rana don makonni 1-2. Don rigakafin cututtukan kumburi bayan tiyata tare da karkatar da ƙwallon ido - 1 sauke sau 4-6 sau / rana a cikin ɗaukacin bayan aikin.

Yawan amfani. Tsawon lokacin jiyya ya dogara da tsananin cutar, hanyar asibiti da kuma sakamakon binciken ƙwayoyin cuta.

Side effects

- halayen rashin lafiyan, tashin hankali mai taushi da kuma haɗuwa tare da hyperemia, tashin zuciya

- jin jikin kasashen waje a idanu

- mummunan dandano a bakin nan da nan bayan instillation

- raguwa cikin ƙwarewar gani

- bayyanar farin kukan farinciki a cikin marassa lafiya da cututtukan mahaifa

tabo ko ɓarna a cikin ƙasa

Mu'amala da Lafiya

Abun hulɗa na magunguna: Maganin ciprofloxacin bai dace da mafita ba game da magunguna yana da ƙimar pH na 3-4, waɗanda ba su da kwanciyar hankali a jiki ko na chemically.

Tare da haɗakar lokaci ɗaya tare da sauran magungunan rigakafi, ana amfani da haɗin kai na synergistic (rigakafin beta-lactam, aminoglycosides, clindamycin, metronidazole).

Umarni na musamman

Tare da kulawa: an tsara magungunan ga marasa lafiya da cututtukan cerebral arteriosclerosis, haɗarin cerebrovascular, syndrome na sanƙara.

Maganin a cikin hanyar saukad da idanuwa ba a nufin allura na ciki ba.

Ba za a iya gudanar da maganin ba a cikin subconjunctival ko kai tsaye cikin ɗakin ido na ido.

Lokacin amfani da wasu magunguna na ophthalmic, tsakani tsakanin aikinsu ya zama akalla minti 5.

Idan, bayan amfani da saukad da, hyperemia na haɗin gwiwa ya ci gaba ko ƙaruwa na dogon lokaci, to ya kamata ku daina amfani da maganin kuma ku nemi likita.

Ruwan ido na Ciprofloxacin-AKOS yana dauke da sinadarin hana ido na bacci na benzalkonium, wanda zai haifar da fushin ido da ruwan tabarau mai taushi. Saboda haka, kafin amfani da miyagun ƙwayoyi Ciprofloxacin-AKOS, mai haƙuri ya kamata ya cire ruwan tabarau na hulɗa kuma ya sanya su a cikin mintina 15 bayan instillation.

Siffofin tasiri na miyagun ƙwayoyi akan karfin tuka abin hawa ko ƙwararrun haɗari

Marasa lafiya waɗanda aka rasa asarar hangen nesa na ɗan lokaci bayan aikace-aikacen ba da shawarar su fitar da mota ko yin aiki da injin ƙira, injinan ko duk wani kayan aiki na zamani wanda ke buƙatar hangen nesa nan da nan bayan ƙirar maganin.

Fitar saki da kuma kwantena

Ido ya fadi 0.3%.

5 ml a cikin kwalabe don ƙwaƙwalwar ido tare da bututun mai ƙwanƙwasa da ƙwanƙolin filastik.

5 ml a cikin kwalabe masu ruwa na polymer tare da dunƙule mai ruɓi da ƙugin ƙaura. Ialara guda ɗaya tare da umarnin don amfani da magani a cikin jihohi da harsunan Rasha ana sanya su cikin fakitin kwali

Tsarin saki, abun da aka shirya da marufi

Ciprofloxacin-AKOS yayi kama da mafificin bayani tare da ruwan rawaya mai laushi mai haske ko kore. Ana samun maganin a cikin kwantena 5 ml, kowane ɗayan yana da digo.

Shirye-shiryen ya ƙunshi abubuwa masu zuwa:

• ciprofloxacin hydrochloride - babban sinadaran, 3 MG a cikin 1 ml na bayani,
• anhydrous ko 3-aqueous sodium acetate, acetic acid, mannitol, da sauransu (ƙarin mahadi).

Ruwan ido sune maganin rigakafi-fluoroquinolones, samfuran antimicrobial. Kowane vial tare da kayan magani an sanya shi a cikin ƙaramin akwati, tare da umarnin tare da ƙa'idodin amfani.

Contraindications

Umarnin don yin amfani da rahotanni: magungunan sun ta'allaka a gaban kwayar cutar keratitis, lalacewar cututtukan ido. Kada ayi amfani da mafita ta hanyar mutanen da ke da damuwa da abubuwan da ke ciki.

Tare da taka tsantsan da taka tsantsan, ana saukar saukadwa ga marasa lafiya da rikice-rikice kamar su arteriosclerosis, hanji, da kuma yaduwa cikin kwakwalwa.

Sashi da gudanarwa

An shigar da kayan aikin a cikin ƙananan kwalin na ido. Ana amfani da maganin bisa ga shawarwarin masu zuwa:

1. Don cututtuka masu laushi ko matsakaici - 1-2 saukad da hutun awa 4.
2. Tare da kamuwa da cuta, 2 saukad kowace awa.

Sashi na kwayoyi da yawan gudanarwarsa yana raguwa yayin da bayyanar cututtukan ke raguwa. Doctor ya saita tsawon likitan ne daban-daban. A matsakaici, jiyya na tsawon makonni 1-2.

Amfani da saukad da lokacin haila da kuma lactation

Duk da gaskiyar cewa kwayar halitta mai aiki ta saukad da sauƙin shiga cikin shinge na ƙwarya kuma cikin madara, idan akwai buƙatar gaggawa, ana iya tsara maganin ga mai juna biyu ko mara lafiyar. Amfani da mafita a lokacin shayarwa da shayarwa shi ne kawai bayan an yi la’akari da duk sakamakon da zai yiwu da kuma wariyar su.

Side effects

Abubuwan da ke haifar da sakamako masu illa waɗanda ke ci gaba yayin amfani da Ciprofloxacin-AKOS galibi ana bayyana su ta hanyar halayen gida:

• itching
• ƙonawa
• karamin ciwo
• taron hadin gwiwa,
• kumburin ido,
• lacrimation
• keratitis
• keratopathy
• samuwar aibobi a kashin,
• rashin ƙarfi ga haske,
• abin mamaki na kasantuwar a cikin kallon abin na kasashen waje.

Nan da nan bayan instillation, aftertaste mara dadi da ke cikin bakin na iya bayyana, ɓarke ​​na ɗan lokaci akan aikin gani. Daga cikin yanayin mummunan yanayin da ke cikin marasa lafiya da ke cikin jiyya tare da wannan fluoroquinolone, ana rikodin tashin zuciya.

Idan haɗin gwiwa na hyperemia yana da damuwa koyaushe a kan asalin amfani da saukad da idanu, ya kamata a dakatar da amfani da miyagun ƙwayoyi kuma ku nemi likitan ku.

Tsarin sakin samfuri, abun da ke ciki da kuma shirya shi

Ciprofloxacin-Akos saukadden idanu ana sanya su a cikin hanyar bayyanannun bayani na launin kore-rawaya ko launin shuɗi.

Ilaya daga cikin milliliter ya ƙunshi milligrams na ciprofloxacin (a cikin nau'i na hydrochloride). Abubuwa masu zuwa suna aiki kamar abubuwa masu taimako: gishiri mai disodium na ethylenediaminetetraacetic acid, ruwa d / i, mannitol ko mannitol, benzalkonium chloride, glacial acetic acid, sodium acetate, ruwa mai-uku ko anhydrous.

Siffar saki shine kwalaben tsintsiya na polyethylene miliyan biyar a cikin fakiti.

Siffofin Magunguna na Magunguna

Dangane da umarnin, Ciprofloxacin-Akos wakili ne na maganin rigakafi, mai amfani da maganin rigakafi. Yana amfani da ƙwayoyin cuta. Yana hana kwayar halittar DNA ƙirar ƙwayar cuta (topoisomerases IV da II, waɗanda ke da alhakin aukuwar chromosomal supercoiling kusa da makaman nukiliya RNA, wannan ya zama dole don karanta bayanan gado), ya lalata haɗin kwayar halittar DNA, rarrabuwa ta ƙwayoyin cuta da haɓaka, kuma yana haifar da canje-canje na zahiri (ciki har da membranes da cell ganuwar) da hanzarta lalata ƙwayar ƙwayar cuta.

Yana bactericidal da gram-korau microorganisms a lokacin rarrabe da dormancy (tun da shi ke shafar ba kawai DNA gyrase, amma kuma tsokani lysis na tantanin halitta), gram-tabbatacce microorganisms - kawai kan aiwatar da rarrabuwa.

Rage yawan guba ga ƙwayoyin macroorganism za'a iya bayanin su ta hanyar rashin ƙwaƙwalwar ƙwayar DNA a cikin su.

A lokaci guda, a kan asalin ciprofloxacin, daidaituwa na samar da juriya ga wasu kwayoyin rigakafi waɗanda ba su da shinge masu hanawa, ba sa faruwa, wanda ya sa miyagun ƙwayoyi su kasance masu tasiri sosai a kan ƙwayoyin cuta masu tsayayya, alal misali, zuwa tetracyclines, cephalosporins, penicillins, aminoglycosides da sauran maganin rigakafi.

Yawancin staphylococci masu tsayayya da methicillin suna da tsayayya ga ciprofloxacin. Juriyar kwayar cuta mai saurin yaduwa tana haɗu a hankali, tunda, a gefe guda, babu kusan ƙananan ƙwayoyin cuta da suka rage bayan tasirin ciprofloxacin, kuma a gefe guda, babu wani enzymes a cikin ƙwayoyin ƙwayoyin cuta waɗanda suke lalata shi.

Manuniya da contraindications

Ana amfani da "Ciprofloxacin-Akos" don:

• subacute da m conjunctivitis,
• post-da preoperative prophylaxis na ophthalmic m cututtuka,
• blepharoconjunctivitis, basur,
• cutar kumburi da gabobin hangen nesa bayan shigar azzakarin cikin abubuwa na kasashen waje ko raunin da ya faru,
• keratoconjunctivitis, keratitis,
• meibomite
• na kullum dacryocystitis
• mai cutar mahaifa ta dabi'ar ƙwayar cuta.

• tare da hoto ko bidiyo mai zagaya yanar gizo da sauri keratitis,
• tare da hankalin kowane mutum ga abun da ke ciki,
• yara yan shekara daya.

Littafin koyarwa

Ana amfani da "Ciprofloxacin-Akos" a cikin gida, ta hanyar narke su cikin jakar haɗin. Idan mai haƙuri yana da kamuwa da cutar ido na matsakaici da ƙarfi, ya kamata a saka digo ɗaya ko biyu cikin cikin abin da ya shafa kowane awa huɗu. Idan kamuwa da cuta mai tsanani ne, to ana yin ɗabi'ar kowane sa'o'i biyu. An rage yawan amfani da amfani yayin da yanayin ke inganta. Aikin da yake yi na tsawon wata daya zuwa biyu.

Tare da cututtukan ƙwayar cuta

Amfani da “Ciprofloxacin-Akos” idan ana cutar da ƙwayar ƙwayar cuta: rana ta farko - faɗuwa da faɗuwa kowane kwata na awa shida, sannan kowace rabin sa'a ta sauka har zuwa lokacin bacci na dare, a rana ta biyu - sauke daga safe zuwa dare tare da tazara ta awa guda, s a rana ta uku ta goma sha huɗu - kowane sa'o'i huɗu a cikin ido ƙasa da faɗuwa. Idan mai rauni bai warke ba, za a iya ci gaba da ba da magani.

Wajibi ne a rufe kwalbar bayan kowane amfani. Haramun ne a taɓa ido da ƙyallen yatsa.

Sharuɗɗan hutu na kantin

Tarayyar Rasha, 640008, Kurgan, Avenue Constitution, 7.

tel / fax (3522) 48-16-89

Rijistar Rijistar Rijista

Kira OJSC, Tarayyar Rasha

Adireshin kungiyar wanda ya yarda da da'awar daga masu sayayya kan ingancin kayayyaki a cikin yankin kasar Kazakhstan kuma yana da alhakin sanya ido kan rajistar kula da lafiyar miyagun ƙwayoyi a cikin yankin ƙasar Kazakhstan

Deсalog LLP, 050050, Kasar Kazakhstan,

Aikin magunguna

Babban wakilin maganin rigakafi mai mahimmanci daga rukuni na fluoroquinolones (wani yanki na monofluoroquinolones) don amfani da Topical a cikin maganin ophthalmology. Yana hana kwayar halittar DNA kwayar cuta (topoisomerases II da IV, da alhakin supercoiling na chromosomal DNA a kusa da makaman nukiliya RG, wanda yake wajibi ne don karanta bayanan kwayoyin), ya lalata kwayar halittar DNA, haɓakar ƙwayoyin cuta da rarrabuwa, kuma yana haifar da sauye-sauyen ƙwayoyin cuta (ciki har da bangon sel da membranes) da saurin mutuwar kwayar halitta.

Yana aikata ƙwayoyin cuta akan kwayoyin gram-mara kyau yayin hutawa da rarrabuwa (tunda yana shafar ba kawai DNA goge ba, har ma yana haifar da ƙirar bangon tantanin halitta), da ƙananan ƙwayoyin gram-tabbatacce ne kawai yayin lokacin rarrabuwa. Theara yawan yanayin bangon ƙwayar cuta.

Yayin shan ciprofloxacin, babu wani ci gaban layi daya na tsayayya da sauran ƙwayoyin rigakafi waɗanda ba sa cikin rukunin masu hana ƙyalli, wanda ke ba da tasiri sosai ga ƙwayoyin cuta waɗanda ke tsayayya da aminoglycosides, penicillins, cephalosporins, tetracyclines da sauran wasu ƙwayoyin rigakafi.

Ciprofloxacin yana da aikin invitro da yawa na gram-tabbatacce kuma gram-korau microorganisms. Ayyukan kwayoyin cuta na ciprofloxacin yana faruwa ne ta hanyar bayyanawa ga tsohuwar ƙwayar halittar DNA, wanda ya zama dole don haɗin DNA na ƙananan ƙwayoyin cuta. An gano cewa ciprofloxacin yana da tasirin aiki azaman maganin invitro a kan mafi yawan nau'ikan kwayoyin halittar masu zuwa:

Gram-tabbatacce:

• Staphylococcus aureus (wanda ya haɗa da methicillin mai rikitarwa da rikice-rikice na methicillin), ƙwayar ƙwayar cuta na staphylococcus, ƙwayar ƙwayar cutar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, ptoungiyar ƙwayoyin cuta (ptoungiyar Viridans).

Gram-korau:

• Haemophilus mura, Pseudomonas aeruginosa, Serratia marcescens.

Binciken in vitro ya nuna cewa ciprofloxacin yana aiki da akasarin cututtukan kwayoyin halittar masu zuwa, kodayake ba a tantance mahimmancin asibitin wadannan bayanan ba:

Gram-tabbatacce:

• Enterococcusfaecalis (damuwa dayawa suna daukar hankali ne kawai), Staphylococcushaemolyticus, Staphylococccushominis, Staphylococcussaprophytics, Staphylococcuspyogenes.

Gram-korau:

• Acinetobacter calcoaceticus subsp. anitratus, Aeromonas caviae, Aeromonas hydrophila, Brucella melitensis, Campylobacter coli, Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Edwardsiella tarda, Enterobacter aerogenes, Enterobacter cloacaeli, Escherichoi Moraxella (Branhamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Salmonella fibrero, Shigella fibrene , Yersinia enterocolitica.

Sauran kwayoyin:

• Chlamydia trachomatis (kawai yana cikin sauki mai saurin kamuwa da ita) da kuma tarin fuka na Mycobacterium (kawai na cikin sauki).

Yawancin nau'ikan Pseudomonas cepacia da wasu nau'ikan Pseudomonas maltophilia suna tsayayya da ciprofloxacin, kamar yawancin ƙwayoyin anaerobic, ciki har da Bacteroides fragilis da Clostridium difficile.

A cikin juriya na vitro ciprofloxacin yakan zama sannu a hankali (maye gurbi).

Sakawa lokacin

Shawarar da aka bada shawarar don magance cututtukan mahaifa sune kamar haka:

• saukad da biyu a cikin ciwon mara kowane mintina 15 na farkon awanni shida na farko, sannan kuma saukad da biyu a cikin tsananin ciwon duk mintina 30 cikin ragowar lokacin farko. A rana ta biyu, shigar da saukad da biyu a cikin tsananin ciwon kowace awa. A rana ta uku kuma har zuwa kwanaki 14, allura sau biyu a cikin ciwon mara kowane awa hudu. Idan kwanaki 14 bayan jiyya, sake sake fasalin ƙwayar cutar bai faru ba, za a iya ci gaba da jiyya.

Ingantaccen tsarin kulawa da aka ba da shawara ga cututtukan ƙwayoyin cuta:

• daya ko biyu saukad a cikin jakar / jaka a kowane sa'o'i biyu a rana ta farko. Sannan a cikin kwanaki biyar masu zuwa, daya ko biyu ya ragu a kowane awa hudu.

Matsakaicin lokacin magani ga kowane daga cikin cututtukan shine kwana 21.

Hulɗa da ƙwayoyi

Babu wani bincike na musamman akan hulɗar ciprofloxacin tare da zubar da ido tare da wasu kwayoyi. Koyaya, tsarin amfani da wasu abubuwan quinolones ya haifar da karuwar tarooolllline a cikin ƙwayar plasma, sakamako akan metabolism na maganin kafeyin, da kuma haɓaka tasiri na maganin anticoagulants, warfarin da abubuwan da aka samo shi. Har ila yau, an lura da haɓaka mai ba da izini a cikin kwayar halittar creatinine idan mai haƙuri yana shan cyclosporine a lokaci guda.

Idan yin amfani da wasu magungunan ophthalmic da aka yi niyya, amfanin su ya kamata a raba cikin lokaci zuwa hutun mintina 15.

Magunguna tare da ingantaccen tsarin haɗari don tsawanta tazara QT:

Ciprofloxacin, kamar sauran fluoroquinolones, ya kamata a yi amfani dashi tare da taka tsantsan a cikin marasa lafiya da ke karɓar kwayoyi tare da sanannen haɗarin haɗari don tsawaita tazara ta QT (alal misali, aji IA da III antiarrhythmic kwayoyi, magungunan tricyclic antidepressants, macrolides, antipsychotics.

Tuntu ruwan tabarau

Ba ya da kyau a taɓa sa ruwan tabarau mai laushi lokacin magani. Idan ana amfani da ruwan tabarau mai wuya, to kuna buƙatar cire su a gaban hanya kuma ku sake sanya su a cikin mintina 15-20 bayan gudanar da magani.

Tasiri kan iyawar marasa lafiya don sarrafa injin da hawa abin hawa: mutanen da suka rasa ma'anar hangen nesa bayan amfani da Ciprofloxacin-Akos ba a basu damar yin aiki tare da injinan gaske, kayan aiki ko injin, ko tuka mota ba, tunda ana bukatar bayyananniyar hangen nesa kai tsaye bayan hanyoyin.

Yanayin ajiya da rayuwar shiryayye

Ya kamata a adana saukad da ƙwayoyin cuta a cikin wani wuri mai kariya daga haske, ƙarƙashin yanayin zafin jiki na +15 zuwa +25 ° C. Kada a daskarar da miyagun ƙwayoyi. Ba a cire damar samun magunguna ga ƙanananan yara da dabbobi da ke zaune a cikin gida ba.

Tsayayyen rayuwar ophthalmic bayani a cikin rufin da aka rufe shi ne shekara 2. Bayan an buɗe akwati tare da miyagun ƙwayoyi, ya kamata a yi amfani da abubuwan da ke ciki don nufin da ya dace na kwanaki 28.

Don maye gurbin samfurin na asali, masu amfani suna zuwa:

• Athenoxine.
• Basira.
• Vero-Ciprofloxacin.
• Ciprinol.
• Microflox.
• Quintor.
• Ammar
• Nircip.

Abubuwan samfuran da aka lissafa suna da alaƙa tare da bayanin da aka bayyana, suna da haɗakar gaba ɗaya, kaddarorin warkewa da alamomi don amfani. Hakanan ana samun magunguna iri ɗaya a cikin nau'in faɗuwar idanu kuma an tsara su don yin shigarwa.

Ciprofloxacin-AKOS magani ne mai tsada mai tsada wanda ke taimakawa wajen yakar cututtukan idanu da dama. Magungunan suna da farashi mai araha, wanda ya kama daga 23-36 rubles Ana sayar da shi a cikin kantin magani tare da takardar sayan magani. Kafin amfani da wannan kayan aiki, ya zama dole don yin gwajin ophthalmic kuma sami takardar sayan likita.

Yadda ake amfani: sashi da hanya na jiyya

A ciki, 0.25 g sau 2-3 a rana, tare da mummunan cututtuka - 0.5-0.75 g sau 2-3 a rana.

Game da cututtukan urinary fili - 0.25-0.5 g sau 2 a rana, hanya ta lura - kwana 7-10.

Tare da cututtukan da ba a haɗa su ba - 0.25-0.5 g sau ɗaya, tare da haɗuwa da kamuwa da cuta na gonococcal tare da chlamydial da mycoplasma - 0.75 g kowane sa'o'i 12 na kwanaki 7-10.

Tare da chancroid - 0.5 g sau 2 a rana don kwanaki da yawa.

Tare da jigilar meningococcal a cikin nasopharynx - sau ɗaya, 0.5 ko 0.75 g.

A cikin jigilar jigilar mutane na Salmonella, ta bakin, 0.25 g sau 4, hanya ta lura har zuwa makonni 4. Idan ya cancanta, za a iya ƙara yawan zuwa 0.5 g sau 3 a rana.

Tare da ciwon huhu, osteomyelitis - a ciki, 0.75 g sau 2 a rana. Tsawan lokacin jiyya na osteomyelitis na iya zuwa watanni 2.

Don kamuwa da cututtukan gastrointestinal da Staphylococcus aureus ke haifar, 0.75 g kowane sa'o'i 12 na kwanaki 7-28.

Ya kamata a ci gaba da lura da aƙalla kwanaki 3 bayan daidaita yanayin zafin jiki ko ɓacewar alamun bayyanar cututtuka.

A dunkula mai tacewa (CC 31-60 ml / min / 1.73 sq.m ko maida hankali a kwayar halitta daga 1.4 zuwa 1.9 mg / 100 ml), matsakaicin adadin yau da kullun shine 1 g. A adadin adadin filter a kasa 30 ml / min / 1.73 sq. m ko taro na creatinine maida hankali akan 2 mg / 100 ml; matsakaicin adadin yau da kullun - 0.5 g.

Idan mai haƙuri ya sha wahala ta hanyar hemodialysis ko peritoneal dialysis - 0.25-0.5 g / day, amma ya kamata a sha miyagun ƙwayoyi bayan zaman hemodialysis.

A cikin cututtuka masu zafi (alal misali, cututtukan cututtukan ƙwayar cuta na ƙwayar cuta, cututtukan ƙwayar ciki, kasusuwa da gidajen abinci) wanda ke haifar da Pseudomonas ko staphylococci, ciwon huhu da ya haifar ta hanyar ƙwayar cuta taptoptococcus, da cututtukan chlamydial na ƙwayar ƙwayar cuta, yakamata a ƙara yawan zuwa 0.75 g kowane 12 hours.

Ya kamata a hadiye allunan tare da karamin adadin ruwa bayan abinci. Lokacin ɗaukar kwaya a kan komai a ciki, ƙwayar abu mai narkewa tana karɓa da sauri.

Isar da ruwa cikin ciki: lokacin jiko shine mintuna 30 a kashi 0.2 g da mintuna 60 a kashi 0.4 g .. Hanyoyin jiko, shirye suke don amfani, ana iya haɗe tare da 0.9% NaCl bayani, Ringer na maganin da Ringer-lactate, 5 da 10% bayani dextrose, bayani na 10% na fructose, kazalika da maganin da ya ƙunshi 5% dextrose bayani tare da 0.225-0.45% NaCl bayani.

Tare da cututtukan urinary na ciki wanda ba a haɗa shi ba, ƙananan ƙwayar jijiyoyin ƙwayar cuta, kashi ɗaya shine 0.2 g, tare da rikitarwa na ciki na hanjin urinary na sama, tare da mummunan cututtuka (ciki har da ciwon huhu, osteomyelitis), kashi ɗaya shine 0.4 g. Idan ya cancanta, / a cikin kulawa musamman mawuyacin hali, barazanar rayuwa ko maimaitawar cututtukan ƙwayar cuta ta hanyar Pseudomonas, staphylococci ko ƙwaƙwalwar ƙwayar cuta na Streptococcus, ana iya ƙara kashi zuwa 0.4 g tare da mitar gudanarwa har sau 3 a rana. Tsawon lokacin jiyya na maganin osteomyelitis na iya zuwa watanni 2.

Tare da jigilar jigilar kayayyaki na Salmonella - 0.2 g 2 sau a rana, hanya ta magani - har zuwa makonni 4. Idan ya cancanta, za a iya ƙara yawan zuwa 0.5 g sau 3 a rana.

A cikin mummunar cuta - 0.1 g sau ɗaya.

Don rigakafin kamuwa da cuta yayin ayyukan tiyata - 0.2-0.4 g na tsawon awoyi na 0.5-1 kafin a yi tiyata, tare da tsawon lokacin tiyata fiye da sa'o'i 4, ana sake sarrafawa a cikin kashi ɗaya.

Matsakaicin tsawon lokacin magani: kwana 1 - tare da ciwo mai rikitarwa na ciki da cystitis, har zuwa 7 kwanaki - tare da kamuwa da cuta da kodan, urinary tract da ciki, cikin duka tsawon lokacin da ke cikin ƙawancen neutropenic - a cikin marasa lafiya tare da raunana garkuwar jiki, amma ba fiye da watanni 2 ba - tare da osteomyelitis da kwanaki 7-14 - tare da duk sauran cututtuka. Tare da cututtukan streptococcal saboda haɗarin rikice-rikice na ƙarshen, tare da cututtukan chlamydial, kulawa ya kamata a kalla kwanaki 10. A cikin marasa lafiya da rigakafi, ana aiwatar da jiyya a duk tsawon lokacin neutropenia.

Ya kamata a gudanar da jiyya don akalla kwanaki 3 bayan al'adawar zafin jiki ko ɓacewar alamun bayyanar cututtuka.

A cikin adadin tacewa duniya (CC 31-60 ml / min / 1.73 sq. M ko serin creatinine maida hankali daga 1.4 zuwa 1.9 mg / 100 ml), matsakaicin adadin yau da kullun shine 0.8 g.

A duniyan tacewar duniya (CC a kasa 30 ml / min / 1.73 sq.m ko maida hankali a kwayar halitta a saman 2 mg / 100 ml), matsakaicin adadin yau da kullun shine 0.4 g.

Ga tsofaffi marasa lafiya, ana rage kashi 30%.

Tare da peritonitis, yana halatta amfani da gudanarwar intraperitoneal na maganin jiko a cikin kashi 50 MG sau 4 a rana da 1 lita na dialysate.

Bayan iv, ana iya ci gaba da magani a baki.

Haɗa kai

Sakamakon raguwa a cikin ayyukan aiwatar da hadawar hada karfi na microsomal a cikin hepatocytes, yana kara maida hankali tare da tsawaita T1 / 2 na theophylline (da sauran xanthines, alal misali maganin kafeyin), magungunan baka, da kuma maganin rashin daidaituwa, kuma yana taimakawa wajen rage bayanan prothrombin.

Lokacin da aka haɗu da sauran magungunan antimicrobial (maganin beta-lactam maganin rigakafi, aminoglycosides, clindamycin, metronidazole), ana lura da synergism sau ɗaya, ana iya amfani dashi cikin nasara tare da azlocillin da ceftazidime don cututtukan da Pseudomonas spp., Tare da meslocillin, azlocetilin l, da dai sauransu. maganin rigakafi - don cututtukan streptococcal, tare da isoxazolepenicillins da vancomycin - don kamuwa da cututtukan staphylococcal, tare da metronidazole da clindamycin - don kamuwa da cututtukan anaerobic.

Yana haɓaka tasirin nephrotoxic na cyclosporine, an lura da karuwa a cikin ƙwayoyin serin creatinine, a cikin irin waɗannan marasa lafiya, sarrafa wannan alamar sau 2 a mako ya zama dole.

A lokaci guda, yana haɓaka tasirin maganin rashin daidaituwa.

Gudanarwa ta baka tare da magungunan Fe-dauke da kwayoyi, sucralfate da magungunan antacid waɗanda ke dauke da Mg2 +, Ca2 + da Al3 + suna haifar da raguwa a cikin ƙwayar ciprofloxacin, don haka ya kamata a tsara shi 1-2 sa'o'i kafin ko 4 sa'o'i bayan shan magungunan da ke sama.

NSAIDs (ban da ASA) na kara haɗarin kamuwa da cuta.

Didanosine yana rage yawan ciprofloxacin saboda samuwar hadaddun abubuwa tare da shi wanda ke dauke da Al3 + da Mg2 + wadanda ke cikin hadanosine.

Metoclopramide yana haɓaka sha, wanda ke haifar da raguwa a lokacin da ya isa Cmax.

Gudanar da magungunan uricosuric yana haifar da raguwa a cikin kawar (har zuwa 50%) da kuma haɓaka cikin ƙwayar plasma na ciprofloxacin.

Maganin jiko yana da cikakkiyar jituwa tare da duk mafita na kayan jiko da kwayoyi waɗanda ba su da tsayayyen jiki da chemically a cikin yanayin acidic (pH na ciprofloxacin jiko bayani shine 3.9-4.5). Kada ku haɗa mafita don gudanar da iv tare da mafita suna da pH fiye da 7.

Tambayoyi, amsoshi, sake dubawa game da magungunan Ciprofloxacin-AKOS

Bayanin da aka bayar an yi shi ne don ƙwararrun likitoci da magunguna. Cikakken bayani game da magani yana kunshe ne a cikin umarnin da aka haɗe zuwa marufin da mai masana'anta. Babu wani bayani da aka sanya akan wannan ko wani shafin yanar gizon mu wanda zai iya canza matsayin roko na musamman ga kwararrun.