Mildronate® (capsules, 250 MG) Meldonium

Kaya 1 ta ƙunshi:

abu mai aiki - meldonium dihydrate 250 MG,

magabatan - sitaci dankalin turawa, sittin silsila na silsila, alli na sitarat, kauri (jiki da murfi) - titanium dioxide (E 171), gelatin.

Hard gelatin capsules No. 1 na farin launi. Abun ciki farin lu'ulu'u ne mai sanyin kamshi. Foda yana hygroscopic.

Pharmacodynamics

Meldonium tsari ne mai mahimmanci ga carnitine, analog na tsarin gamma-butyrobetaine (GBB), wani abu ne wanda aka samo a cikin kowane sel a cikin jikin mutum.

A karkashin yanayin karuwar kaya, meldonium ya dawo da daidaituwa tsakanin isar da bukatar oxygen na sel, yana kawar da tara kayan abinci mai guba a cikin sel, yana kare su daga lalacewa, haka kuma yana da tasirin tonic. Sakamakon amfani da shi, juriya na jiki ga damuwa da ikon iya mayar da kayan ajiyar makamashi cikin sauri yana ƙaruwa.

Magungunan yana da tasiri mai ban sha'awa ga tsarin juyayi na tsakiya (CNS) - karuwa a cikin aikin motsa jiki da jimiri na jiki. Saboda waɗannan kaddarorin, ana amfani da MILDRONAT® don haɓaka aikin jiki da na kwakwalwa.

Kayan magunguna

Pharmacokinetics

Bayan gudanar da maganin baka, ƙwayar magunguna tana cikin sauri, bioavailability shine 78%. Matsakaicin maida hankali ne akan samu sa'o'i 1-2 bayan gudanarwa. Metabolized a cikin jiki tare da samuwar manyan abubuwa guda biyu

metabolites da ke fitar da kodan. Rabin rayuwar lokacin da aka baka a baki shine sa'o'i 3-6.

Pharmacodynamics

Meldonium (Mildronate®) analog ne na tsarin tsari na daidaituwa na carnitine gamma butyrobetaine (a nan ne GBB), a ciki ana maye gurbin iskar hydrogen guda ɗaya. Ana iya bayanin tasirinsa a jiki ta hanyoyi biyu.

Tasiri kan tsarin carnitine

Sakamakon hanawar ayyukan butyrobetaine hydroxylase, meldonium yana rage biosynthesis na carnitine kuma saboda haka yana hana jigilar daskararren sarkar acid ta hanyar membrane, yana hana tarin abubuwanda aka kunna na acid na unoxidized mai, uncyccarnitine da acylcoenzyme mai, da wadatar, da acylcoenzyme A karkashin yanayin ischemia, Mildronate® ya dawo da daidaituwa tsakanin isar da oxygen da amfani a cikin sel, yana kawar da rikicewar zirga-zirgar ababen hawa na ATP, a lokaci guda yana kunna madadin tushen makamashi - glycolysis, wanda aka gudanar ba tare da ƙarin amfani da oxygen ba.

Tare da karuwar kaya a sakamakon yawan kuzari mai ƙarfi a cikin ƙwayoyin jikin lafiya, raguwa na ɗan lokaci a cikin abubuwan da ke tattare da kitse yana faruwa. Wannan, bi da bi, yana ƙarfafa metabolism na kitse mai ƙiba, galibi ƙirar carnitine. Ana sarrafa biosynthesis na carnitine ta matakan plasma da damuwa, amma baya dogaro da taro na abubuwan carnitine a cikin tantanin halitta. Tunda meldonium yana hana canzawar GBB zuwa carnitine, wannan yana haifar da raguwa a matakin carnitine a cikin jini, wanda hakan yana kunna aikin carnitine, shine, GBB. Tare da raguwa a cikin taro na meldonium, an sake dawo da tsarin carnitine biosynthesis kuma an daidaita taro na kitse a cikin tantanin halitta. Don haka, ƙwayoyin suna yin horo na yau da kullun, wanda ke ba da gudummawa ga rayuwarsu a ƙarƙashin yanayin ƙara nauyi, a cikin abin da yake rage yawan abubuwan da ke cikin mai a kai a kai, kuma lokacin da aka rage nauyin, an mai da abun cikin mai mai sauri cikin sauri. A cikin yanayin nauyi mai nauyi, sel 'sun horar da su' 'tare da taimakon miyagun ƙwayoyi Mildronate® suna rayuwa a cikin waɗancan yanayin lokacin da ƙwayoyin “marasa koyarwa” suka mutu.

Matsakaici ne na GBB-ergic tsarin

An gano cewa a jikin mutum akwai wani tsari da ba a baiyana yadda ake yada jigilar jijiyoyi ba - tsarin GBB-ergic, wanda ke tabbatar da isar da jijiyoyin jijiya zuwa sel. Matsakanci na wannan tsarin shine ainihin farkon carnitine - a GBB ester. Sakamakon esterase, wannan

matsakanci yana ba da wutan lantarki zuwa tantanin halitta, don haka yana canja wurin wutar lantarki, kuma ita kanta ta zama GBB.

Tsarin haɗin GBB yana yiwuwa a kowane sel na jikin mutum. Saurinsa yana daidaitawa ne ta hanyar girman kuzarin da kuzarin kuzari, wanda hakan ya dogara da carnitine. Sabili da haka, tare da raguwa a cikin carnitine maida hankali, ana inganta aikin haɗin GBB. Don haka, a cikin jikin akwai jerin larura na tattalin arziki wanda ke ba da amsa ga ƙarancin fushi ko damuwa: yana farawa da karɓar sigina daga ƙwayoyin jijiya (a cikin nau'ikan lantarki), tare da haɗin GBB da ester, wanda, bi da bi, yana ɗaukar siginar a kan wata membranes sel. Kwayoyin Somatic a cikin amsa ga haushi suna haɗa sabbin ƙwayoyin halitta, suna samar da yaduwar siginar. Bayan wannan, nau'in GBB mai ruwa da haɗuwa tare da haɗakar sufuri mai aiki ya shiga hanta, kodan da gwaje-gwaje, inda ya juya zuwa carnitine. Kamar yadda aka ambata a baya, meldonium tsari ne na tsarin GBB, a ciki ana maye gurbin iskar hydrogen guda ɗaya daga zarra na nitrogen. Tunda ana iya fallasa meldonium zuwa GBB-esterase, zai iya zama matsayin "matsakanci" na gaba-gaba ". Koyaya, GBB-hydroxylase baya tasiri ga meldonium sabili da haka, lokacin da aka gabatar dashi cikin jiki, yawan carnitine baya ƙaruwa, amma yana raguwa. Sakamakon gaskiyar cewa meldonium kanta tana aiki a matsayin "matsakanci" na damuwa, kuma yana ƙara yawan abubuwan da ke cikin GBD, yana ba da gudummawa ga haɓakar amsawar jiki. A sakamakon haka, ayyukan metabolism na gaba ɗaya a cikin sauran tsarin, alal misali, tsarin juyayi na tsakiya (CNS), yana ƙaruwa.

Alamu don amfani

- angina pectoris da infarction na zuciya (a matsayin wani ɓangare na cututtukan farji)

- rashin lafiyar zuciya na kullum (a cikin hadadden magani)

- m hatsarin cerebrovascular (a hadadden far)

- hemophthalmus da retinal basur na daban-daban etiologies, thrombosis daga cikin tsakiyar retinal jijiya da kuma rassan, retinopathy na daban-daban etiologies (ciwon sukari, hauhawar jini)

- nauyin kwakwalwa da na jiki, gami da tsakanin 'yan wasa

- cire ciwo a cikin rashin shan barasa (a hade tare da takamaiman magani don shan giya)

Sashi da gudanarwa

Sanya wa manya a ciki.

Cutar zuciya

A matsayin ɓangare na ƙwaƙƙwarar magani, 0.5-1.0 g kowace rana ta bakin, ɗaukar ɗayan kashi ɗaya yanzu ko rarraba shi zuwa allurai 2. Hanyar magani shine makonni 4-6.

Cardialgia akan asalin cutar zuciya - ta bakin, 0.25 g sau 2 a rana. Hanyar magani shine kwana 12.

Hadarin Cerebrovascular

Ana amfani da lokaci mai ƙwanƙwasa - ana amfani da nau'in sashi na maganin don kwana 10, sannan sai suka canza zuwa shan miyagun ƙwayoyi ta hanyar 0.5-1.0 g kowace rana. Babban aikin jiyya shine makonni 4-6.

Bala'i na ƙwayar cuta na yau da kullun - 0.5 g a baki kowace rana. Babban aikin jiyya shine makonni 4-6. Ana maimaita darussan (yawanci sau 2-3 a shekara) yana yiwuwa bayan tattaunawa da likita.

Hemophthalmus da retinal basur na daban-daban etiologies, thrombosis daga cikin tsakiyar retinal jijiya da kuma rassan, retinopathy na daban-daban etiologies (ciwon sukari, hauhawar jini)

Ana amfani da nau'in sashi na maganin don kwana 10, sannan sai suka canza zuwa shan maganin a baki a 0.5 g kowace rana, ɗaukar kashi ɗaya gaba ɗaya ko rarraba shi zuwa allurai 2. Aikin jiyya shine kwanaki 20.

Loadaukar da hankali da ta jiki, gami da tsakanin athletesan wasa

Manya 0.25 g a baki sau 4 a rana. Aikin magani shine kwanaki 10-14. Idan ya cancanta, ana maimaita magani bayan makonni 2-3.

'Yan wasan 0.5-1.0 g a baki sau 2 a rana kafin horo. Tsawon lokacin karatun a cikin kwanakin shiri shi ne 14-21, a lokacin gasar - kwanaki 10-14.

Cutar rashin shan giya na yau da kullun

A ciki, 0.5 g sau 4 a rana. Aikin jiyya shine kwanaki 7-10.

Contraindications

- Hypersensitivity ga aiki abu ko ga wani abu mai taimako na miyagun ƙwayoyi

- increasedara yawan matsa lamba cikin wulakanci (a ketarewar ambaliyar ruwa, ciwan ciki)

- ciki da lactation, saboda karancin bayanai game da amfani da magani a wannan lokacin

- yara da matasa da ke ƙasa da shekara 18, saboda ƙarancin bayanai game da amfani da magani a wannan lokacin

Mu'amala da Lafiya

Yana haɓaka sakamako na jijiyoyin bugun zuciya, wasu magungunan antihypertensive, bugun zuciya.

Ana iya haɗe shi da magungunan antianginal, anticoagulants, jami'in antiplatelet, magungunan antiarrhythmic, diuretics, bronchodilators.

Saboda yiwuwar ci gaban tachycardia na matsakaiciya da tawaitar jini, yakamata a yi taka-tsantsan lokacin da aka haɗu da kwayoyi tare da sakamako iri ɗaya.

Umarni na musamman

Ya kamata a yi taka tsantsan a cikin marasa lafiya da cututtukan hanta da cututtukan koda tare da tsawwala amfani da miyagun ƙwayoyi.

Mildronate® ba magani ne na farko-don cututtukan cututtukan zuciya ba.

Siffofin tasiri na miyagun ƙwayoyi akan karfin tuka motoci ko ƙirar mai haɗari

Yakamata a yi taka tsantsan lokacin tuka abin hawa ko injunan da ke da haɗari.

Yawan abin sama da ya kamata

Ba a san shari'ar yawan adadin ƙwayar yawan ƙwayoyi tare da miyagun ƙwayoyi Mildronate®, miyagun ƙwayoyi ba mai guba bane.

Game da yawan abin sama da ya kamata - lura da cututtukan zuciya.

Fom ɗin saki

Capsules 250 MG. Ana sanya capsules 10 a cikin farin murfin murfin polyvinyl chloride fim tare da rufin polyvinylidene da kuma aluminium. Ana sanya allunan sel guda 4 tare da umarni don amfani a cikin jihar da kuma yaren Rasha ana saka su cikin fakiti na kwali.

Pharmacokinetics

Bayan gudanar da maganin baka, ƙwayar magunguna tana cikin sauri, bioavailability shine 78%. Mafi yawan maida hankali (C_max) cikin jini jini ana samun sa'o'i 1-2 bayan fitowar fata. Yana cikin metabolized a jiki akasari a hanta tare da samuwar wasu manyan metabolites guda biyu wadanda kodan ke bankwana da su. Rabin rayuwa (T₁/₂) lokacin da aka baka ta baki, ya danganta da maganin, shine awowi 3-6.

Yi amfani da lokacin daukar ciki da lokacin shayarwa

Ba a yi nazarin lafiyar lafiyar mata masu juna biyu ba, saboda haka, don a daina haifar da lahani a cikin tayin, an hana yin amfani da miyagun ƙwayoyi a cikin mata masu juna biyu.

Ba a yi nazarin hawan ciki ba tare da madara da tasirin lafiyar lafiyar jariri ba, saboda haka, idan ya cancanta, amfani da miyagun ƙwayoyi ya kamata ya daina shayarwa.

Side sakamako

Meldonium an yarda da shi sosai. Koyaya, a cikin marasa lafiya mai saurin kamuwa, har ma a lokuta da suka wuce shawarar da aka bada shawarar, halayen da ba a so.
Ba a yarda da halayen magungunan da ba a so kamar yadda aka tsara gabobin tsarin gabobi bisa ga yawan canjin mita: sau da yawa (> 1/10), sau da yawa (> 1/100 da 1/1000 da 1/10 000 da