Metfogamma 1000 umarnin don amfani, contraindications, sakamako masu illa, sake dubawa

Sunan duniya:Metfogamma 1000

Abun ciki da nau'i na saki

Allunan, an shafe su tare da farin fim na hoto, suna da yawa, tare da haɗari, tare da kusan babu wari. Kwamfutar hannu 1 ta ƙunshi 1000 mg na meformin hydrochloride. Fitowa: hypromellose (15000 CPS) - 35.2 mg, povidone (K25) - 53 MG, magnesium stearate - 5.8 mg.

Harsashi abun da ke ciki: hypromellose (5 CPS) - 11.5 mg, macrogol 6000 - 2.3 mg, titanium dioxide - 9.2 mg.

A cikin blister 30 ko allunan 120. Sanya cikin akwatin kwali.

Clinical da kungiyar magunguna

Oral hypoglycemic magani

Rukunin Magunguna

Hypoglycemic wakili don baka na sarrafa rukunin biguanide

Tsarin magunguna na Metfogamma 1000

Magungunan hypoglycemic na baka daga ƙungiyar biguanide. Yana hana gluconeogenesis a cikin hanta, rage yawan glucose daga hanji, haɓaka amfani da keɓaɓɓen glucose, yana kuma ƙara haɓakar jijiyoyin jikin mutum zuwa insulin. Ba ya shafar ɓarin insulin ta sel-cells sel na hanji.

Zazzagewa masu saukarwa, LDL.

Yanke ko rage karfin jiki.

Yana da tasirin fibrinolytic saboda hanawar ƙwaƙwalwar ƙwaƙwalwar ƙwayar plasminogen mai hanawa.

Pharmacokinetics

Bayan gudanar da baki, ana amfani da metformin daga ƙwayar narkewa. Bioavailability bayan ɗaukar daidaitaccen kashi shine 50-60%. C max bayan maganin baka an sami nasara bayan awa 2

A zahiri ba a ɗaura shi da sunadaran plasma. Yana tarawa a cikin glandan ciki, tsokoki, hanta, da kodan.

An cire shi baya cikin fitsari. T 1/2 shine 1,5-4.5 hours.

Pharmacokinetics a cikin lokuta na musamman na asibiti

Tare da nakasa aikin na koda, tarawa daga cikin miyagun ƙwayoyi yana yiwuwa.

Nau'in ciwon sukari na 2 na ciwon sukari (wanda ba shi da insulin-in-ins) ba tare da sha'awar ketoacidosis (musamman ma a cikin marasa lafiya tare da kiba) tare da maganin rashin abinci.

Contraindications

Hypersensitivity, hyperglycemic coma, ketoacidosis, na kullum na koda, gawar hanta, gazawar zuciya, myocardial infarction, gazawar numfashi, rashin ruwa, cututtuka masu yaduwa, yawan aiki da raunin jiki, shan giya, rage yawan kalori (kasa da 1000 kcal / day), lactic acidosis (hade da tarihin), ciki, lactation. Ba a sanya magungunan a cikin kwanaki 2 kafin tiyata, radioisotope, nazarin x-ray tare da gabatarwar magunguna masu bambanci kuma a cikin kwanaki 2 bayan aiwatarwarsu Tare da taka tsantsan. Sama da shekaru 60, yin aiki na jiki mai nauyi (ƙara haɗarin haɓakar lactic acidosis a cikinsu).

Sashi da tsarin da hanyar aikace-aikace Metfogamma 1000

Saita daban, yin la'akari da matakin glucose a cikin jini.

Maganin farko shine yawanci 500 MG-1000 mg (1 / 2-1 shafin.) / Day. Furtherarin ƙarin ci gaba na digiri a kan hanya yana yiwuwa gwargwadon tasirin aikin jiyya.

Adadin kulawa shine 1-2 g (Allunan 1-2) / rana. Matsakaicin adadin yau da kullun shine 3 g (Allunan 3). Dalilin maganin a cikin allurai masu girma ba ya kara tasirin magani.

Allunan yakamata a ɗauka tare da abinci gaba ɗaya, a wanke da ruwa kaɗan (gilashin ruwa).

Magungunan an yi niyya don amfani na dogon lokaci.

Saboda yawan haɗarin lactic acidosis, a cikin rikice-rikice na rayuwa mai rauni, yakamata a rage kashi.

Side effects

Daga tsarin narkewa: tashin zuciya, amai, ciwon ciki, zawo, rashin ci, ƙarar ƙarfe a bakin (a matsayin mai mulkin, ba a buƙatar magani, kuma alamu sun ɓace a kan kansu ba tare da canza sashi na miyagun ƙwayoyi ba, za a iya rage yawan tasirin sakamako tare da karuwa a hankali na yawan metformin), da wuya - rikicewar cututtukan cututtukan cututtukan hanta, hepatitis (wuce bayan karban magani).

Allergic halayen: fata tayi.

Daga tsarin endocrine: hypoglycemia (lokacin amfani da allurar da ba ta dace ba).

Daga gefen metabolism: da wuya - lactic acidosis (yana buƙatar dakatarwa da magani), tare da tsawan amfani - hypovitaminosis B₁₂ (malabsorption).

Daga tsarin hawan jini: a wasu halaye - megaloblastic anemia.

Haihuwa da lactation

An sanya maganin don amfani a lokacin daukar ciki da lactation (shayar da nono) .Ansar da amfani ga aikin hanta mai rauni.Ya sanya magungunan don amfani da aikin hanta mai lalacewa.

Yi amfani da shi a cikin tsofaffi marasa lafiya

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin marasa lafiya waɗanda suka girmi shekaru 60 waɗanda suke yin aiki na zahiri, saboda haɗarin haɗarin lactic acidosis.

Umarnin na musamman don shigarwa Metfogamma 1000

Lokacin yin jiyya, saka idanu akan aikin koda ya zama dole; ƙayyadadden lactate plasma ya kamata a yi aƙalla sau 2 a shekara, kuma tare da bayyanar myalgia. Tare da haɓaka lactic acidosis, ana buƙatar dakatar da magani. Ba a bada shawarar yin alƙawarin kamuwa da cuta mai tsanani, raunin da ya faru, da haɗarin bushewa. Tare da haɗuwa da magani tare da abubuwan da aka samo asali na sulfonylurea, saka idanu a hankali kan taro na glucose jini yana da muhimmanci. Ana amfani da haɗakar amfani da insulin a asibiti.

Yawan damuwa

Kwayar cutar mai lactic acidosis na iya bunkasa. Dalilin ci gaban lactic acidosis kuma na iya zama tarin ƙwayar cutar saboda rauni na aikin keɓaɓɓu. Alamomin farko na lactic acidosis sune tashin zuciya, amai, gudawa, zazzage jiki, ciwon ciki, zafin makogwaro, nan gaba mai saurin numfashi, farin ciki, rauni mara nauyi da kuma ci gaba da rashin lafiya.

Jiyya: idan akwai alamun lactic acidosis, magani tare da Metfogamma 1000 ya kamata a dakatar da shi nan da nan, ya kamata a kwantar da mai haƙuri cikin gaggawa kuma, bayan ya ƙaddara yawan maganin lactate, tabbatar da ganewar asali. Hemodialysis yana da tasiri sosai don cire lactate da metformin daga jiki. Idan ya cancanta, gudanar da aikin tiyata.

Tare da maganin haɗin gwiwa tare da maganin sulfonylureas, hypoglycemia na iya haɓaka.

Haɗi tare da Sauran Magunguna

Tare da yin amfani da nifedipine lokaci guda yana ƙara yawan metformin, C_maxrage gudu excretion.

Magungunan cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) waɗanda aka ɓoye a cikin tubules suna gasa don tsarin jigilar tubular kuma, tare da tsawan magani, na iya haɓaka C_max 60% metformin.

Tare da yin amfani da lokaci guda tare da abubuwan da suka samo asali na sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, clofibrate Kalam, cyclophosphamide da beta-blockers, yana yiwuwa a ƙara tasirin hypoglycemic sakamako na metformin.

Tare da yin amfani da lokaci guda tare da GCS, maganin hana haihuwa, epinephrine (adrenaline), sympathomimetics, glucagon, hormones na thyroid, thiazide da loopback diuretics, abubuwan da ke tattare da yanayin acid da nicotinic acid, raguwar sakamako na hypoglycemic na metformin mai yiwuwa ne.

Cimetidine yana rage jinkirin kawar da metformin, sakamakon abin da haɗarin lactic acidosis ke ƙaruwa.

Metformin na iya raunana tasirin magungunan anticoagulants (abubuwan da aka samo coumarin).

Tare da gudanarwa na lokaci ɗaya tare da ethanol, haɓakar lactic acidosis mai yiwuwa ne.

Sharuɗɗan hutu na kantin

Magungunan magani ne.

Sharuɗɗan da yanayin ajiya Metfogamma 1000

Ya kamata a adana miyagun ƙwayoyi daga isar yara a zazzabi da bai wuce 25 ° C ba. Rayuwar shelf shine shekaru 4.

Yin amfani da miyagun ƙwayoyi Metfogamma 1000 kawai kamar yadda likita ya umarta, an ba da bayanin don tunani!

Leaseaddamar da fom na Metfogamma 1000, kayan tattarawa da magunguna

Allunan mai rufi
Shafin 1
metformin hydrochloride
1 g

Mahalarta: hypromellose (15,000 CPS), magnesium stearate, povidone (K25).

Harshen Shell: hypromellose (5CPS), macrogol 6000, titanium dioxide.

10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (12) - fakitoci na kwali.
Guda 15. - blister (2) - fakitoci na kwali.
Guda 15. - blisters (8) - fakitoci na kwali.

LITTAFIN SAURARON SAUKI.
Duk bayanan da aka bayar an gabatar dasu ne kawai don fahimtar tare da miyagun ƙwayoyi, ya kamata ka nemi likita game da yiwuwar amfani.

Aikin Pharmacological Metfogamma 1000

Wakili hypoglycemic wakili daga rukuni na biguanides (dimethylbiguanide). Hanyar aiwatar da metformin yana da alaƙa da iyawarta don dakatar da gluconeogenesis, kazalika da samuwar ƙwayoyin mai mai kyauta da hadawar hada hada abubuwa da hada abubuwa da kitse na mai. Metformin baya tasiri da yawan insulin a cikin jini, amma yana canza magunguna ta hanyar rage ragin insulin da za'a ɗauka kyauta da kuma ƙara yawan rabo daga insulin zuwa proinsulin. Haɗi mai mahimmanci a cikin tsarin aikin metformin shine ƙarfafa motsa jini daga ƙwayoyin tsoka.

Metformin yana haɓaka wurare dabam dabam na jini a cikin hanta kuma yana haɓaka juyar da glucose zuwa glycogen. Yana rage matakin triglycerides, LDL, VLDL. Metformin yana haɓaka ƙirar fibrinolytic ta jini ta hanyar dakatar da nau'in mai kunnawa mai hana jini plasminogen.

Pharmacokinetics na miyagun ƙwayoyi.

Ana amfani da Metformin daga narkewa. Cmax a cikin plasma an kai shi kimanin awa 2 bayan shigowa. Bayan awanni 6, sha daga ƙwayar gastrointestinal ya ƙare kuma haɗuwa da metformin a cikin jini yana raguwa a hankali.

A zahiri ba a ɗaura shi da sunadaran plasma. Yana tarawa a cikin glandan ciki, hanta da ƙodan.

T1 / 2 - awa 1.5 --.5.5. Kodan ya keɓe shi.

Idan akwai rauni na aiki na koda, tarawar metformin mai yiwuwa ne.

Sashi da hanyar gudanar da magani.

Ga marasa lafiya da basa karbar insulin, a cikin kwanakin 3 na farko - 500 mg sau 3 / rana ko 1 g 2 sau / rana yayin ko bayan abinci. Daga rana ta 4 zuwa rana ta 14 - 1 g sau 3 / rana. Bayan rana ta 15, ana daidaita sashin shan la'akari da matakin glucose a cikin jini da fitsari. Adadin kulawa shine 100-200 mg / rana.

Tare da yin amfani da insulin a lokaci daya a cikin ƙarancin ƙasa da raka'a 40 / rana, tsarin kulawa na metformin iri ɗaya ne, yayin da za a iya rage yawan insulin a hankali (ta hanyar raka'a 4-8 a kowace rana). Idan mai haƙuri ya sami fiye da raka'a 40 / rana, to, yin amfani da metformin da raguwa a cikin adadin insulin yana buƙatar kulawa sosai kuma ana gudanar da shi a asibiti.

Sakamakon sakamako na Metphogamma 1000:

Daga tsarin narkewa: mai yiwuwa (galibi a farkon jiyya) tashin zuciya, amai, zawo.

Daga tsarin endocrine: hypoglycemia (galibi lokacin da aka yi amfani dashi a cikin allurai marasa inganci).

Daga gefen metabolism: a wasu yanayi - lactic acidosis (yana buƙatar dakatarwa da magani).

Daga tsarin hemopoietic: a wasu yanayi - megaloblastic anemia.

Contraindications wa miyagun ƙwayoyi:

Laifi mai yawa na hanta da kodan, bugun zuciya da gazawar numfashi, lokaci mai tsaiko na myocardial infarction, buguwa mai taushi, cutar sankara, ketoacidosis, lactic acidosis (gami da tarihi), cutar ciwon suga, ciwon ciki, lactation, laushi ga metformin.

FASAHA DA LITTAFINSA
Contraindicated a cikin ciki da kuma lactation.

Umarni na musamman don amfani da Metfogamma 1000.

Ba'a bada shawara ga cututtukan m, daɗaɗɗar cututtukan cututtukan fata da cututtukan kumburi, raunin da ya faru, cututtukan tiyata, da haɗarin rashin ruwa.

Kada ayi amfani dasu kafin aikin tiyata kuma cikin kwanaki 2 bayan an yi su.

Ba'a ba da shawarar yin amfani da metformin a cikin marasa lafiya fiye da shekaru 60 da waɗanda ke yin aiki na zahiri, wanda ke da alaƙa da haɓakar haɓakar lactic acidosis.

Lokacin yin jiyya, ya zama dole don saka idanu akan aikin renal, ƙuduri na abubuwan lactate a cikin plasma ya kamata a aiwatar da su aƙalla sau 2 a shekara, kuma tare da bayyanar myalgia.

Za'a iya amfani da Metformin a hade tare da sulfonylureas. A wannan yanayin, musamman saka idanu na matakan glucose na jini ya zama dole.

Yin amfani da metformin a matsayin wani ɓangare na maganin haɗin gwiwa tare da insulin ana bada shawarar a asibiti.

Yin hulɗa da Metfogamma 1000 tare da wasu kwayoyi.

Tare da yin amfani da lokaci guda tare da abubuwan da aka samo na sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxygentetracycline, ACE inhibitors, tare da clofibrate, cyclophosphamide, tasirin hypoglycemic na metformin na iya inganta.

Tare da yin amfani da lokaci guda tare da GCS, hana rigakafin hormonal don sarrafawa na baka, adrenaline, glucagon, hormones thyroid, abubuwan da ke tattare da kwayoyin halittar thiazide, abubuwan da aka samo na nicotinic acid, raguwar tasirin hypoglycemic na metformin mai yiwuwa ne.

Amfani da cimetidine na iya ƙara haɗarin lactic acidosis.

Hotunan 3D

Pharmacodynamics

Yana hana gluconeogenesis a cikin hanta, rage yawan glucose daga hanji, haɓaka amfani da keɓaɓɓen glucose, da ƙara haɓakar jijiyoyin jikin mutum zuwa insulin. Yana rage matakin triglycerides da ƙarancin lipoproteins mai yawa a cikin jini. Yana da tasirin fibrinolytic (yana hana ayyukan mai amfani da ƙwayar plasminogen mai kunna nama), kwantar da hankali ko rage nauyin jiki.

Side effects

Daga tsarin zuciya da jijiyoyin jini (hematopoiesis, hemostasis): a wasu yanayi megaloblastic anemia.

Daga narkewa: tashin zuciya, amai, ciwon ciki, zawo, rashin ci, daɗin ƙarfe a bakin.

Daga gefen metabolism: hypoglycemia, a cikin mafi yawan lokuta, lactic acidosis (yana buƙatar dakatar da magani).

Allergic halayen: fata tayi.

Mitar da tsananin tasirin sakamako daga narkewa zai iya raguwa tare da karuwa a hankali a kashi na metformin. A cikin halayen da ba kasafai ba, sanadin rikicewar samfuran hanta ko hepatitis ya ɓace bayan cire magani.

Daga gefen metabolism: tare da tsawan magani - hypovitaminosis B₁₂ (malamborption.)

Sashi da gudanarwa

A ciki yayin cin abinci, shan ruwa mai yawa (gilashin ruwa). An saita kashi akayi daban-daban, yin la'akari da tattarawar glucose a cikin jini.

Kashi na farko yawanci 500-1000 MG (1/2 / 1 kwamfutar hannu) kowace rana, ƙarin ƙaruwa na digiri a cikin kashi mai yiwuwa yana dogara ne akan tasirin maganin.

Yawan tallafi na yau da kullun shine 1-2 g (Allunan Allunan 1-2) a rana, matsakaicin - 3 g (Allunan 3) a rana. Neman karin allurai baya kara tasirin magani.

A cikin marasa lafiya tsofaffi, kashi na yau da kullun kada ya wuce 1000 mg / rana.

Ainihin jiyya yana da tsawo.

Saboda haɓakar haɗarin lactic acidosis, kashi na maganin dole ne a rage shi a cikin rikice-rikice na rayuwa mai rauni.

Umarni na musamman

Ba'a ba da shawarar cututtukan m masu raɗaɗi ba ko ɓarna na cututtukan cututtukan fata da raɗaɗi, raunin da ya faru, cututtukan tiyata, kafin tiyata da cikin kwanaki 2 bayan an yi su, kamar yadda kuma cikin kwanaki 2 kafin da bayan gwajin gwaji yin amfani da bambanci da kafofin watsa labarai). Bai kamata a yi amfani da shi ba a cikin marasa lafiya a kan abinci tare da ƙuntatawa a cikin adadin caloric (ƙasa da 1000 kcal / rana).Ba'a bada shawarar amfani da maganin ba a cikin mutanen da suka haura shekaru 60 wadanda suke yin aikin jiki (saboda haɗarin haɓakar haɓakar lactic acidosis).

Yana yiwuwa a yi amfani da miyagun ƙwayoyi a hade tare da abubuwan da ke haifar da maganin sulfonylurea ko insulin. A wannan yanayin, musamman saka idanu na matakan glucose na jini ya zama dole.

Tasiri a kan ikon tuka motoci da aiki tare da kayan aiki. Babu sakamako (lokacin amfani dashi azaman monotherapy). A hade tare da sauran wakilai na hypoglycemic (abubuwan da suka samo asali na sulfonylurea, insulin, da dai sauransu), haɓakar jihohin hypoglycemic mai yiwuwa ne, a cikin ikon ikon fitar da motocin da kuma shiga cikin wasu ayyukan haɗari masu haɗari waɗanda ke buƙatar ƙara kulawa da saurin halayen psychomotor.

Mai masana'anta

Mai riƙe da takardar shaidar rijista: Verwag Pharma GmbH & Co. KG, Kalverstrasse 7, 71034, Beblingen, Jamus.

Mai kera: Dragenopharm Apotheker Püschl GmbH & Co. KG, Jamus.

Ofishin wakilci / kungiyar yarda da da'awar: ofishin wakilin kamfanin Vervag Pharma GmbH & Co. CG a cikin Tarayyar Rasha.

117587, Moscow, babbar hanyar Warsaw, 125 F, bldg. 6.

Waya: (495) 382-85-56.

Yadda ake amfani: sashi da hanya na jiyya

A ciki, lokacin ko kai tsaye bayan cin abinci, don marassa lafiya da ke karɓar insulin - 1 g (Allunan 2) sau 2 a rana don kwanakin farko 3 ko 500 mg sau 3 a rana, sannan daga kwanaki 4 zuwa 14 - 1 g sau 3 a rana, bayan kwanaki 15 za a iya rage sashi yayin yin la'akari da abun da ke cikin glucose a cikin jini da fitsari. Kulawa na yau da kullun - 1-2 g.

Allunan shakatawa (850 MG) ana ɗaukar 1 safe da maraice. Matsakaicin adadin yau da kullun shine 3 g.

Tare da yin amfani da insulin a lokaci daya a cikin ƙarancin ƙasa da raka'a 40 / rana, tsarin kulawa na metformin iri ɗaya ne, yayin da za a iya rage yawan insulin a hankali (ta hanyar raka'a 4-8 a kowace rana). Lokacin da kashi na insulin ya wuce raka'a 40 / rana, yin amfani da metformin da raguwa a cikin yawan insulin yana buƙatar kulawa sosai kuma ana gudanar dashi a asibiti.

Tambayoyi, amsoshi, sake dubawa game da magungunan Metfogamma 1000

Bayanin da aka bayar an yi shi ne don ƙwararrun likitoci da magunguna. Mafi ingantaccen bayani game da miyagun ƙwayoyi yana kunshe ne a cikin umarnin da yazo tare da mai shirya kaya. Babu wani bayani da aka sanya akan wannan ko wani shafin yanar gizon mu wanda zai iya canza matsayin roko na musamman ga kwararrun.

Yin hulɗa tare da wasu kwayoyi

Nifedipine yana ƙara sha, C_tahrage gudu excretion. Magungunan cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, da vancomycin) waɗanda aka ɓoye a cikin tubules suna gasa don tsarin jigilar tubular kuma, tare da tsawan magani, na iya haɓaka C_tah da kashi 60%.

Lokacin da aka yi amfani da su a lokaci guda tare da abubuwan da suka samo asali na sulfonylurea, acarbose, insulin, magungunan anti-mai kumburi steroidal, hanawa na monoamine oxidase inhibitors, oxygentetracycline inhibitors, angiotensin-juyar da magungunan enzyme, • abubuwan da ake amfani da shi, abubuwan amfani da cyclophosphamide, mai amfani da sinadarin glucocococococococococococolecolatas-un-ins , epinephrine, sympathomimetics, glucagon, hormones thyroid, thiazide da dabbobi evymi "diuretics, phenothiazine Kalam, nicotinic acid na iya rage hypoglycemic mataki na metformin.

Cimetidine yana rage jinkirin kawar da metformin, wanda ke kara haɗarin lactic acidosis. Metformin na iya raunana tasirin magungunan anticoagulants (abubuwan da aka samo coumarin). Ta hanyar shan giya a lokaci daya, lactic acidosis na iya haɓaka.

Siffofin aikace-aikace

A lokacin jiyya, wajibi ne don saka idanu kan aikin koda. Aƙalla sau 2 a shekara, kuma tare da bayyanar myalgia, ya kamata a aiwatar da ƙuduri na abubuwan lactate a cikin plasma. Yana yiwuwa a yi amfani da Metfogamma® 1000 a hade tare da abubuwan da suka samo asali na sulfonylurea ko insulin. A wannan yanayin, musamman saka idanu na matakan glucose na jini ya zama dole.

Tasiri a kan ikon tuka motoci da aiki tare da injin Lokacin amfani da miyagun ƙwayoyi a cikin maganin monotherapy, ba ya tasiri da ikon fitar da motocin da kuma aiki da injin. Lokacin da aka haɗu da metformin tare da sauran wakilai na hypoglycemic (abubuwan da keɓaɓɓe na sulfonylurea, insulin, da dai sauransu), yanayin hypoglycemic na iya haɓakawa wanda ikon iya fitar da motoci da shiga cikin wasu ayyukan haɗari masu haɗari waɗanda ke buƙatar ƙara kulawa da saurin psychomotor mai sauri.