Lozarel yana taimakawa wajen daidaita karfin jini

Ana amfani da miyagun ƙwayoyi Lozarel a ƙirar zuciya, endocrinology da nephrology. Umarnin don amfani ya ƙunshi shawarwari don amfanin aikin da ya dace, ya dogara da kayan aikin asibiti.

Tushen maganin shine ƙwayar potassium losartan a cikin adadin 50 MG. Componentsarin abubuwan haɗin sun haɗa da silicon dioxide, magnesium stearate, lactose, sitaci. Abun da yake dashi shima yana da microcrystalline cellulose.

Fom ɗin saki

Za'a iya siyan magani a cikin allunan, wanda aka cakuda a cikin gilashin bakin ciki na allunan 10. A cikin kunshin ɗayan akwai blister 3.

Kwamfutar hannu tana da fararen launi (ƙasa da kullun tare da launin ruwan hoda) da siffar zagaye. A gefe ɗaya akwai hadarin. Fuskar kwamfutar hannu an rufe ta da fim.

Warkewa mataki

Angiotensin 2 amatsayin enzyme wanda, ta hanyar ɗaura wa masu karɓa a cikin zuciya, kodan da adrenal gland, yana haifar da taƙaita ɓarin ƙwayoyin jinin su. Hakanan yana tasiri kan sakin aldosterone. Duk waɗannan tasirin suna haifar da karuwa a cikin jini.

Losartan yana toshe aikin angiotensin 2, ba tare da la’akari da hanyar da aka kirkira ba. Saboda wannan, canje-canje masu zuwa suna faruwa a jiki:

• rage duka na mazaunin jijiyoyin bugun jini,
• matakan aldosterone na jini suna raguwa
• saukar karfin jini
• matakin matsin lamba a cikin jijiyar huhu ya ragu.

Hawan jini yana raguwa saboda ƙananan diuretic sakamako na miyagun ƙwayoyi. Tare da shigarwar yau da kullun, rage haɗarin ƙwayar tsoka na zuciya, haƙuri na motsa jiki a cikin mutane tare da ƙarancin wadatar zuciya na haɓaka.

Matsakaicin sakamako yana faruwa kwanaki 21 bayan fara gudanarwa. An gano tasirin rigakafin a tsakanin rana guda.

An wajabta Lozarel don cututtukan zuciya, cututtukan ƙwayar cutar koda da illa ga metabolism. An nuna magungunan don karuwa a cikin jini saboda cutar rashin lafiya, ko hauhawar jini na ilimin etiology da ba a sani ba.

Ana nuna magungunan don gazawar zuciya (gazawar zuciya), wanda ba a kawar da shi ta hanyar angiotensin-yana canza masu hana enzyme. Tare da haɗuwa da hawan jini, tsufa, hauhawar jini da sauran abubuwa, ana amfani dashi don rage mace-mace da kuma yiwuwar haɗarin jijiyoyin bugun zuciya (bugun zuciya, bugun jini).

Ana amfani da miyagun ƙwayoyi don rikitarwa na nau'in ciwon sukari na 2 na cutar siga - nephropathy, tunda yana rage yiwuwar ci gaban cuta.

Umarnin don amfani

Ana ɗaukar Losartan sau 1 a rana. Ana amfani da kashi 50 na MG don magance hauhawar jini. Idan sauran rukunin magungunan an riga an tsara su, fara da rabin kwamfutar hannu. Idan ya cancanta, ƙara kashi zuwa 100 MG, wanda za'a iya ɗauka sau ɗaya ko kuma ya kasu kashi biyu.

A cikin rauni na zuciya, mafi ƙarancin nauyin 12.5 MG an wajabta. Kowane kwana 7 yana ninki biyu, a hankali yana ƙaruwa zuwa 50 MG. A wannan yanayin, sun mai da hankali ga iyawar miyagun ƙwayoyi. Tare da rabin kashi (25 MG), idan mai haƙuri yana da koda ko gazawar hanta, yana kan hemodialysis.

Don gyara proteinuria a cikin ciwon sukari, an wajabta magunguna a kashi 50 MG / rana. Matsakaicin adadin yau da kullun don wannan ilimin shine 100 MG.

Yanayin aiki bai dogara da abinci ba kuma yakamata ya zama kullun a lokaci guda.

Contraindications

Ba a sanya maganin potassium Losartan don irin waɗannan rukunin marasa lafiya ba:

• tare da rasa ci na glucose ko galactose,
• rashin daidaituwa na glucose,
• galactosemia
• a karkashin shekara 18
• mai ciki
• lactating
• mutane da rashin haƙuri zuwa ga abubuwan da miyagun ƙwayoyi.

Kulawar yanayi yana buƙatar alƙawarin magani don koda ko gazawar hanta, ƙwararriyar ƙwayar cutar koda (2-gefe ko haɗin kai tare da koda guda ɗaya), da raguwa a cikin ƙarar jini na kowane jini etiology. Tare da taka tsantsan, ana amfani da Lozarel don rashin daidaituwa na lantarki.

Alamu don amfani

An wajabta maganin Lozarel idan akwai:

1. A bayyane alamun hauhawar jini.
2. Rage haɗarin kamuwa da cututtukan zuciya a cikin mutanen da ke fama da hauhawar jijiyoyi ko hauhawar jini a ventricular hagu, wanda aka nuna da raguwa a haɗewar yawan cututtukan zuciya, bugun jini da infarction na zuciya.
3. Bayar da kariya daga koda a cikin marassa lafiya da masu ciwon sukari na 2.
4. Bukatar rage proteinuria.
5. Rashin ƙarfin zuciya na rashin ƙarfi tare da gazawar magani daga masu hana ACE.

Side effects

Amincewa da miyagun ƙwayoyi na iya kasancewa tare da halayen masu illa, waɗanda basu da ƙarfi kuma basa buƙatar dakatar da aikinta. An gabatar dasu a cikin tebur.

Rashin halayen da ba na ɗayan rukuni ya ƙunshi gout.

Yawan yawan bayyanar cututtuka

Yawan shaye-shaye yana da irin wannan bayyanuwar: saurin bugun zuciya, raguwar hauhawar jini, saurin bugun zuciya yayin motsa farji.

Ana amfani da diuretics da alamun wakilai don gyara yanayin. Hanyar hemodialysis ba ta da tasiri, tun da ba a cire losartan daga kafofin watsa labarai na halitta ta wannan hanyar ba.

Hulɗa da ƙwayoyi

Haɗewar yin amfani da shi tare da diuretics daga ƙungiyar masu amfani da potassium, har ma da shirye-shiryen da ke ɗauke da sinadarin potassium ko gishirin sa, na iya haifar da haɗarin cutar hyperkalemia. An yi taka tsantsan Lozarel tare da salts na lithium, saboda haɗuwar lithium a cikin jini na iya ƙaruwa.

Yin amfani da miyagun ƙwayoyi tare da fluconazole ko rifampicin na iya rage taro na aiki a cikin plasma. Rage tasiri a cikin tasirin maganin yana faruwa lokacin da aka gudanar da shi tare da magungunan anti-steroidal anti-inflammatory wadanda ba su da steroidal a cikin adadin da ya wuce 3 g.

Losartan ba ya hulɗa da irin waɗannan abubuwan magungunan:

• warfarin
• hydrochlorothiazide,
• digoxin
• dakikidan,
• cimetidine
• karinda78
• ketoconazole.

Magungunan yana inganta tasirin of-blockers, diuretics da sauran magunguna waɗanda ke rage karfin jini.

Umarni na musamman

Losartan baya shafar maida hankali, don haka bayan ɗaukar shi zaku iya fitar da mota kuma kuyi aiki da injuna. A cikin yanayin inda aka rasa kashi na miyagun ƙwayoyi, kwamfutar hannu ta gaba tana bugu nan da nan lokacin da damar ta taso. Idan lokaci ya yi da za a dauki kashi na gaba, suna shan shi daidai gwargwado - kwamfutar hannu 1 (ba a bada shawarar 2 Allunan ba).

Tare da tsawaita amfani da miyagun ƙwayoyi, ana kula da matakin KASAN plasma. Idan ana amfani da miyagun ƙwayoyi a kan asalin manyan magungunan cututtukan diuretics, to akwai haɗarin hauhawar jini. Lozarel yana haɓaka matakin creatinine da urea cikin yanayin koda na koda koda ne, kuma a cikin ɗayan biyun jiragen.

Analogs: Presartan, Lozap, Cozaar, Blocktran, Lorista, Cardomin-Sanovel.

Rashin ƙarancin analogues: Vazotens, Losartan.

Dangane da sake dubawa da yawa, Lozarel yana da haƙuri tare da amfani na dogon lokaci, yana sarrafa matsin lamba a lokacin rana. Ya shahara tsakanin marasa lafiya, kuma sau da yawa likitoci ne ke rubuta shi - masu warkarwa, likitocin zuciya, likitocin iyali. Wasu bita suna da alamun halayen da ba su dace ba.

Adanawa da rayuwar rayuwa

Za'a iya amfani da maganin a cikin shekaru 2 daga ranar da aka sake shi. An adana shi a cikin daki wanda zafinsa bai wuce 25 ° ba.

Ana bada shawarar miyagun ƙwayoyi ne kawai bayan jarrabawa, dakin gwaje-gwaje, gwaji na kayan aiki, gano alamun haɗin ilimin likita. Amfani da kai Lozarel na iya haifar da rikitarwa.

Side effects

Lokacin yin jiyya tare da Losarel, ba a bayyana sakamako masu illa, kuma babu buƙatar dakatar da jiyya.

A cikin mutanen da ke da matsala a cikin tsarin zuciya, cututtukan da ke gaba suna zuwa wasu lokuta:

Tare da cin zarafin ƙwayar gastrointestinal, tashin zuciya, ciwon ciki, maƙarƙashiya, ciwon hakori, ƙwanƙwasa, gastritis, da raunin dandano a koyaushe suna bayyana. Wadannan alamun ba koyaushe suna faruwa a cikin samari.

Amma game da cututtukan fata, cututtukan mahaifa, da bushewar fata, da kuma gumi mai yawa da wuya su faru.

A wani ɓangare na rashin lafiyan, itching, fitsari a kan fata, kuma amya bayyana.

Daga gefen tsarin musculoskeletal sau da yawa akwai jin zafi a baya, kafafu, kirji, arthritis, cramps.

Tare da take hakkin tsarin na numfashi, tari, ciwan hanci, mashako, hanji na faruwa.

A cikin tsarin urinary - lalacewar aikin na koda, kamuwa da urinary fili.

Sashi da gudanarwa

Wajibi ne a ɗauki Allunan a cikin sau ɗaya a rana, ba tare da cin abincin ba.

Tare da hauhawar jini farawa da kuma dosing tabbatarwa shine yawanci kashi 50 a koda yaushe. Idan ya cancanta, za'a iya kawo shi har zuwa 100 MG.

Ga marasa lafiya tare da raunin zuciya karba kashi na farko na 12.5 MG, sannan kuma ninki biyu a mako, wanda yake kawowa 50 MG kowace rana.

Tare da nau'in ciwon sukari na 2, wanda ke tattare da proteinuria, maganin da aka ba da shawarar farko ya kamata ya zama 50 MG sau ɗaya a rana.

Lokacin aiwatar da aikin likita, dangane da hawan jini na mai haƙuri, ana ba shi damar ƙara yawan maganin yau da kullun zuwa 100 MG.

Domin rage hadarin ci gaban zuciya rikitarwa a cikin mutane tare da hauhawar jini, da jijiyoyin jini na hagu, an zaɓi kashi na 50 na mg sau ɗaya a rana. A wannan yanayin, ana iya ƙara yawan sashi zuwa 100 MG kowace rana.

Sharuɗɗan da yanayin ajiya

Adana a zazzabi da bai wuce 25 ° C. Kiyaye miyagun ƙwayoyi daga isa ga ƙananan yara.

Ranar karewa Magungunan shine shekaru 2.

Kada kuyi amfani da miyagun ƙwayoyi bayan ranar karewa.

Kudin magungunan Lazorel sun bambanta dangane da masana'anta da kuma kamfanonin kera magunguna, a Rasha a kan matsakaici yana biyan kuɗi daga 200 rubles.

A cikin Ukraine miyagun ƙwayoyi ba ta yaɗu ba kuma farashi kimanin 200 UAH.

Idan ya cancanta, zaka iya maye gurbin "Lozarel" tare da ɗayan waɗannan kwayoyi:

• Brozaar
• Bugawa
• Vero-Losartan
• Vazotens
• Cardomin-Sanovel
• Zisakar
• Cozaar
• Karzartan
• Lozap,
• Lakea
• Losartan A,
• Losartan Canon
• "Fasahar Losartan",
• Losartan Richter,
• Losartan MacLeods,
• Losartan Teva
• "Lozartan-TAD",
• Losacor
• Lorista
• Presartan
• Karin
• "Renicard."

Yin amfani da analogues don magani ana buƙatar musamman a cikin lokuta inda mai haƙuri yana da haƙurin mutum game da abubuwan da ke cikin miyagun ƙwayoyi. Koyaya, likita kawai zai iya ba da kowane irin magani.

Ana iya samun ra'ayoyi na miyagun ƙwayoyi a yanar gizo, alal misali, Anastasia ya rubuta: “Cutar sankarau tana haifar da azaba mai yawa. Ba da daɗewa ba, na fuskanci sabon bayyanar wannan cutar. An kuma kamu da cutar nephropathy. Likita ya ba da adadi da yawa na kwayoyi daban-daban, ciki har da Lozarel. Shi ne ya taimaka wajan hanzarta dawo da tsarin aikin kodan. Kafa kafafu ya ɓace. ”

Ana iya samun sauran bita a ƙarshen wannan labarin.

An san Lozarel na miyagun ƙwayoyi azaman magani mai tasiri wajen lura da hauhawar jini da raunin zuciya. Yana da jerin hanyoyin analogues tare da manyan abubuwan da aka yi kama da su, ba a bada shawara ba don matsalolin hanta da kodan, kazalika a lokacin daukar ciki da kuma kasa da shekaru 18. Don hana faruwar sakamako, ana bada shawarar a sha magani sosai kamar yadda likita ya umarta.

Form sashi

Allunan da aka sanya fim-12.5 MG, 25 MG, 50 MG, 75 MG, 100 MG

Tabletaya daga cikin kwamfutar hannu mai rufe jiki ta ƙunshi

abu mai aiki - losartan potassium 12.5 MG ko 25 MG ko 50 MG ko 75 MG ko 100 MG

tsoffin abubuwan: microcrystalline cellulose, povidone, sitaci glycolate (nau'in A), silicon dioxide colloidal anhydrous, magnesium stearate,

Abinda aka shirya fim: farin opadray (OY-L-28900), lactose monohydrate, hypromellose, titanium dioxide (E 171), macrogol, indigo carmine (E 132) varnish aluminum (don sashi na 12.5 mg).

Allunan-fim masu launi, m, shuɗi, an zana su da "1" a gefe ɗaya (don sashi na 12.5 mg).

Allunan da aka saka a fim suna da kyau, farare ne a launi, tare da daraja guda a kowane gefe da kuma zane mai “2” a gefe guda (na maganin 25 MG).

Allunan da aka rufe fim din suna da kyau, farare ne a launi, tare da daraja guda daya a kowane bangare da kuma “3” wanda yake rubutu a gefe daya (na maganin 50 MG).

Kwayoyin, rufe-fim, cike da farare, da fari, tare da hadari guda biyu a kowane bangare kuma aka zana "4" a gefe ɗaya (na maganin 75 MG).

Kwayoyin, rufe-fim, cike da farin fari, da fari, tare da hadari guda uku a kowane bangare kuma aka zana "5" a gefe guda (na maganin 100 MG).

Aikin magunguna

Bayan sarrafawa na baka, losartan yana da kyau kuma yana ɗaukar matakan metabolism tare da ƙirƙirar metabolite mai aiki na carbonxylic acid, da sauran metabolites marasa aiki. Tsarin bioavailability na losartan a cikin kwamfutar hannu shine kusan 33%. Matsakaicin matsakaiciyar yawan losartan da aiki metabolite ana kai su bayan 1 awa kuma bayan awanni 3-4, bi da bi.

Losartan da metabolite mai aiki sune ≥ 99% suna ɗaure su da ƙwayoyin plasma, galibi ga albumin. Ofimar rarraba losartan shine lita 34.

Kimanin 14% na kashi na losartan, lokacin da aka gudanar dashi a cikin ciki ko lokacin da aka sha shi ta baki, ya juya zuwa cikin aikin metabolite din. Bayan gudanarwar cikin jijiya ko shigar jini na 14C wanda aka yiwa alama mai lakabinsa na lasartan, aikin rediyo na jini da yake gudana shine wakilcin losartan da metabolite mai aiki. An lura da ƙaramin losartan zuwa metabolite mai aiki a cikin kusan kashi 1% na marasa lafiya a cikin karatun. Baya ga metabolite mai aiki, ana kuma samar da metabolites masu aiki.

Theaddamar da ƙwayar plasma na losartan da metabolite mai aiki shine kusan 600 ml / minti da 50 ml / minti, bi da bi. Arasar dangin na losartan da aiki na metabolite shine kusan 74 ml / minti da 26 ml / minti, bi da bi. Lokacin da ake amfani da losartan, kusan 4% na kashi an cire shi a cikin fitsari kuma kusan 6% na kashi an fesa shi a cikin fitsari azaman metabolite mai aiki. Magungunan pharmacokinetics na losartan da metabolite mai aiki suna layi ne yayin da ake shigo da potassium a losartan a allurai har zuwa 200 MG.

Bayan gudanarwar baka, yawan losartan da aiki a cikin jini na jini sukan ragu sosai, rabin rayuwar karshe shine kimanin awa 2 da awanni 6 zuwa 9, bi da bi.

Losartan da metabolite din nata basa aiki sosai a cikin jinin jini yayin da ake amfani da kashi 100 na MG sau daya a rana.

Losartan da aiki metabolite suna keɓe cikin bile da fitsari. Bayan gudanarwar baki, kusan 35% da 43% an fallasa su cikin fitsari, kuma 58% da 50% tare da feces, bi da bi.

Magunguna a cikin rukunin masu haƙuri

A cikin tsofaffi marasa lafiya da ke fama da hauhawar jijiya, yawan losartan da aiki a cikin jini ba sa bambanta sosai da wadanda aka samu a cikin matasa marasa lafiya da hauhawar jini.

A cikin marasa lafiya da hauhawar jini na jijiya mace, matakin losartan a cikin plasma jini ya ninka sau biyu fiye da na marasa lafiya masu cutar hawan jini na jijiya, yayin da matakan metabolite mai aiki a cikin jini na jini ba su bambanta da maza da mata.

A cikin marasa lafiya masu laushi zuwa matsakaici na giya, matakan losartan da aiki metabolite a cikin jini na jini bayan gudanar da baki sun kasance sau 5 da 1.7, bi da bi, sama da na samari maza marasa lafiya.

A cikin marasa lafiya da keɓancewar creatinine sama da 10 ml / min, yawan ƙwayoyin plasama na losartan bai canza ba. Idan aka kwatanta da marasa lafiya da keɓaɓɓen aikin renal, a cikin marasa lafiya akan hemodialysis, ƙungiyar ta AUC (yanki a ƙarƙashin lokutan taro) don losartan ya kusan sau 2 mafi girma.

A cikin marasa lafiya da gazawar renal ko a cikin marasa lafiya akan hemodialysis, ƙwaƙwalwar ƙwayar plasma na metabolite mai aiki iri ɗaya ne.

Losartan da aiki metabolite ba su keɓance ta hanyar motsa jiki ba.

Losartan shine mai hana angiotensin II mai karɓar antagonist (nau'in AT1) don amfani da baki. Angiotensin II - vasoconstrictor mai ƙarfi - shine hormone mai aiki na tsarin renin-angiotensin kuma ɗayan mahimman abubuwan da ke cikin pathophysiology na hauhawar jini. Angiotensin II ya ɗaure wa masu karɓa na AT1, wanda aka samo a cikin kyallen takarda da yawa (alal misali, a cikin ƙarancin tsokoki na tasoshin jini, glandar adrenal, kodan da zuciya), ƙayyade yawancin mahimman abubuwan ilimin halittu, ciki har da vasoconstriction da sakin aldosterone.

Angiotensin II kuma yana karfafa haɓaka ƙwayoyin tsoka mai santsi.

Losartan ya zazzage masu karɓar AT1. Losartan da masana'anta masu aiki da ƙwaƙwalwar ƙwayar cuta - carboxylic acid (E-3174) - toshe duk mahimmancin ilimin halittar jiki na angiotensin II, ba tare da la'akari da tushen ko hanyar aikin ba.

Losartan bashi da tasirin gaske kuma baya toshe wasu masu karɓar ƙwayar jijiyoyi ko tashoshin ion da suke aiki da tsarin tsarin jijiyoyin zuciya. Haka kuma, losartan baya hana ACE (kininase II), wani enzyme wanda ke inganta rushewar bradykinin. A sakamakon haka, babu haɓaka a cikin faruwar sakamako masu illa da ke tattare da bradykinin.

A lokacin amfani da miyagun ƙwayoyi Lozarel kawar da mummunan juyawa na rashin damuwa na angiotensin II don renin ɓoye yana haifar da karuwa a cikin aikin renon plasma (ARP). Irin wannan karuwa a cikin aiki yana haifar da karuwa a cikin matakin angiotensin II a cikin jini. Duk da wannan karuwa, aikin antihypertensive da raguwa a cikin taro na aldosterone a cikin jini na plasma ya ci gaba, wanda ke nuna ingantaccen shinge na masu karɓar angiotensin II. Bayan katse losartan, aikin renin plasma renin da matakan angiotensin II na tsawon kwana 3 su koma zuwa gindi.

Dukansu losartan da babban metabolite suna da kusanci sosai ga masu karɓar AT1 fiye da na AT2. Metabolite mai aiki yana sau 10 zuwa 40 yana aiki fiye da losartan (lokacin da aka canza shi zuwa taro).

Singleari ɗaya na losartan a cikin marasa lafiya tare da matsanancin hauhawar jini zuwa matsakaici yana nuna raguwar ƙididdiga a cikin systolic da hauhawar jini. Matsakaicin tasirin losartan yana haɓaka sa'o'i 5-6 bayan gudanarwa, tasirin warkewa yana ci gaba cikin sa'o'i 24, don haka ya isa ya ɗauka sau ɗaya a rana.

Magunguna da magunguna

Losartan takamaiman mai karɓar angiotensin II ne (nau'in AT1) antagonist.

• yana ɗaure wa masu karɓa na AT1, waɗanda suke a cikin ƙoshin ƙwayoyin tsoka mai santsi na jijiyoyin jini, zuciya, kodan, da kuma a cikin ƙwayoyin adrenal,
• yana da sakamako mai vasoconstrictive, yana saki aldosterone,
• yadda yakamata ya hana angiotensin II,
• baya bada gudummawa ga murkushewar kinase II - enzyme wanda ke lalata bradykinin.

"Lozarel," kamar yadda aka tabbatar da bayanin maganin, ya fara aiki nan da nan. Bayan awa daya, maida hankali ne lazortan ya kai matsayin maida hankali, tasirin yaci gaba har awanni 24. Da tabbaci, matsi yana raguwa awanni 6 bayan shan kwaya. Ana lura da ingantaccen sakamako na antihypertensive bayan makonni 3-6. Losartan ya danganta zuwa gazkar albumin da kashi 99%, wanda kodan ya cire ta kuma hanjin hanjinsa.

Yawan damuwa

Bayyanar cututtuka: Babu lokuta da aka samu ƙarin yawan shaye-shayen ƙwayoyi. Wataƙila alamun alamun yawan zubar da jini zai zama hypotension arterial, tachycardia, bradycardia na iya faruwa saboda tashin hankali na parasympathetic (vagal).

Jiyya: Lokacin da bayyanar cututtuka ta asali, ya kamata a ba da magani mai taimako. Jiyya ya dogara da tsawon lokacin da ya shuɗe bayan ɗaukar Lozarel, da kuma yanayin da tsananin alamun. Ya kamata a ba da muhimmiyar mahimmanci ga kwantar da hankalin tsarin zuciya. Dalilin carbon mai aiki. Kulawa da ayyuka masu mahimmanci. Hemodialysis ba shi da tasiri, tunda ba losartan ko metabolite mai aiki da ke keɓewa lokacin hemodialysis.

Pharmacokinetics

Bayan gudanar da baki, losartan yana da kyau daga ƙwayar gastrointestinal. A farkon sashi ta hanta, yana yin aiki da metabolism ta hanyar carbonxylation tare da halartar CYP2C9 isoenzyme da samuwar metabolite mai aiki. Tsarin bioavailability na losartan shine kusan 33%. Mafi yawan maida hankali (C_max) na abu mai aiki Lozarel a cikin jijiyoyin jini yana isa bayan kimanin 1 hour, kuma mai aiki na metabolite bayan sa'o'i 3-4. Abincin abinci na lokaci daya baya tasiri a bioavailability na losartan. A cikin adadin har zuwa 200 MG, losartan yana kula da magunguna masu layi.

Haɗin zuwa sunadaran plasma na jini (galibi tare da albumin) - fiye da 99%.

V_d (distributionaddamarwar rarraba) shine lita 34.

Kusan baya shiga shingen jini-kwakwalwa.

Har zuwa 14% na maganin baka na losartan an canza shi zuwa metabolite mai aiki.

Tabbatar da maganin plasama na losartan shine 600 ml / min, keɓaɓɓe na ɗan ƙasa shine 74 ml / min, aiki mai aiki shine 50 ml / min da 26 ml / min, bi da bi.

Kimanin 4% an keɓance ta ta hanyar kodan ba canzawa, har zuwa 6% na kashi da aka yarda a cikin hanyar metabolite mai aiki. Sauran an cire ta cikin hanjin.

Karshen rabin rayuwar mai aiki akai shine kimanin sa'o'i 2, matsanancin aiki - har zuwa awa 9.

Gabanin tushen amfani da Lozarel a cikin kashi 100 na yau da kullun, ana ganin ƙaramin losartan da metabolite mai aiki a cikin jini na jini.

Tare da laushi zuwa matsakaici mai zurfi na cirrhosis na giya, yawan losartan yana ƙaruwa sau 5, kuma metabolite mai aiki - sau 1.7, idan aka kwatanta da marasa lafiya ba tare da wannan ilimin ba.

Hulɗar da losartan a cikin plasma na jini a cikin marasa lafiya tare da keɓantaccen keɓancewar creatinine (CC) sama da 10 ml / min yana kama da wanda ke cikin marasa lafiya tare da aikin na al'ada. Tare da CC kasa da 10 ml / min, ƙimar jimlar yawan ƙwayoyi (AUC) a cikin jini na jini yana ƙaruwa sau 2.

Tare da maganin hemodialysis, losartan da metabolite mai aiki ba su cire daga jiki.

A cikin maza masu fama da hauhawar jini a tsohuwar tsufa, matakin maida hankali kan magunguna a cikin jini bai bambanta sosai da sigogi iri ɗaya a cikin samari.

Tare da hauhawar jini ta jijiya a cikin mata, yawan ƙwayar cutar plasama na losartan ya ninka sau 2 fiye da na maza. Abun cikin metabolite mai aiki yana kama. Bambancin magungunan da aka nuna ba shi da mahimmanci na asibiti.

Yadda za a ɗauka kuma a wane matsa lamba, sashi

Ana amfani da "Lozarel", umarnin don amfani wanda ke bayyana ingantaccen tsarin kulawa don cututtuka daban-daban, ana amfani dasu ba tare da abinci ba. Allunan suna sha a lokaci guda sau ɗaya a rana a cikin sashi na likita da shawarar.

Tare da hauhawar jini (hawan jini a kai a kai sama da 140/90 mm Hg), ana ɗaukar maganin a 50 MG kowace rana. Dangane da alamu, ana ƙaruwa sashi zuwa matsakaicin 100 MG. Tare da rage BCC, lura da hauhawar jini yana farawa daga 25 MG. A wane yanayi ne ake nuna karfin jini da maganin, a kowane yanayi likita ya yanke hukunci.

Ana magance rashin nasarar zuciya bisa ga wani tsari. Farjin yana farawa da nauyin 12.5 na magani kowace rana. Kowane mako, ana ninka kashi biyu: 25, 50, 100 MG. Idan ya cancanta, zaku iya karbar 150 MG na "Lozarel" kowace rana.

Tare da nephropathy raunin nau'in ciwon sukari na II, marasa lafiya suna ɗaukar 50 mg na miyagun ƙwayoyi kowace rana. Yana yiwuwa a ƙara yawan zuwa mafi girman 100 MG. Wannan makirci iri ɗaya ya dace da marasa lafiya da hauhawar jini ventricular hagu.

Mahimmanci! Ga tsofaffi marasa lafiya (fiye da shekara 75), marasa lafiya da cututtuka daban-daban na hanta ko kodan, tsarin kulawa na likita yana daidaita ta likita ta fuskar rage yawan maganin yau da kullun.

Haɗa kai

Haɗin "Lozarel" tare da NSAIDs na iya haifar da gazawar koda. Ingancin magungunan antihypertensive yana raguwa sosai.

Haɗuwa tare da kwayoyi masu ɗauke da ƙwayoyin lithium suna haifar da karuwa a cikin ƙwayar plasma.

Tsarin daskararre na potassium a cikin tandem tare da "Lozarel" na iya haifar da faruwar cutar hyperkalemia.

Wannan magani yana inganta tasiri akan jikin magungunan antihypertensive. Lokacin rubuta "Lozarel" tare da masu hana ATP, ya zama dole a sanya ido a kai a kai yanayin yanayin kodan, tunda yiwuwar tasirin cutar yana ƙaruwa sosai.

Ana iya maye gurbin "Lozarel" tare da madadin magani tare da irin wannan sakamako. Misalai:

Magunguna sun sha bamban da farashi da mai ƙira. Amma ba lallai ne ku canza "Lozarel" wanda likitanku ya tsara don wani magani ba. Yakamata ya zaɓi ƙwararren masanin gwani wanda ya tantance halin rashin haƙuri na mai haƙuri da kuma darajar ingancin magunguna a kowane yanayi.

Lozarel, umarnin don amfani: hanyar da sashi

Ana ɗaukar allunan Lozarel a baki, ko da abincin.

• hauhawar jijiyoyin jini: kashi na farko da na tabbatarwa - 50 mg sau ɗaya a rana. A cikin rashin isasshen sakamako na asibiti a cikin wasu marasa lafiya, ana ba da izinin ƙaruwa har zuwa 100 MG, a wannan yanayin, ana ɗaukar allunan sau 1 ko sau 2 a rana. Tare da maganin kwantar da hankali tare da babban allurai na diuretics, yakamata a fara amfani da Lozarel tare da 25 MG (1/2 kwamfutar hannu) sau ɗaya a rana,
• rauni na zuciya: kashi na farko shine 12.5 MG (1/4 kwamfutar hannu) lokaci 1 a rana, kowane kwana 7 ana kara kashi 2 a hankali, sannu a hankali yana kara shi zuwa 50 MG kowace rana, da aka bashi damar jurewa,
• nau'in ciwon sukari guda 2 na furotin tare da proteinuria (don rage haɗarin haɓakar hypercreatininemia da proteinuria): kashi na farko shine 50 MG sau ɗaya a rana. Dogaro da sigogi na karfin jini yayin jiyya, ana iya kara kashi zuwa 100 MG a cikin allurai 1 ko 2,
• hauhawar jijiyoyin jini a cikin marasa lafiya da hawan jini na ventricular hagu (rage ƙarancin haɓaka rikicewar cututtukan zuciya da mace-mace): kashi na farko shine 50 MG sau ɗaya a rana, idan ya cancanta, ana iya ƙara zuwa 100 MG.

Ga marasa lafiya da ke fama da rauni na aikin ƙirar ƙasa (CC ƙasa da 20 ml / min), tarihin cutar hanta, rashin ruwa, fiye da shekaru 75 ko lokacin dialysis, yakamata a ƙaddamar da farawa na yau da kullun na Lozarel a cikin adadin 25 MG (1/2 kwamfutar hannu).

Game da illa mai aiki na renal

Ya kamata a yi taka tsantsan wajen lura da marasa lafiya da gazawar koda, da bijiyoyin biji da jijiyoyin koda, ƙoshin jijiya koda.

Shawarar da aka ba da shawarar don aikin keɓaɓɓen aiki (CC kasa da 20 ml / min): kashi na farko - 25 MG (1/2 kwamfutar hannu) sau ɗaya a rana.

Ra'ayoyi akan Lozarel

Nazarin game da marasa lafiya na Lozarel da ƙwararru suna da gaskiya. Likitoci sun lura cewa miyagun ƙwayoyi, ban da aikin antihypertensive, yana da ƙarin tasirin diuretic. Kudin shiga Lozarel yana shakatar da kaya kuma yana hana farawa da haɓakar hauhawar jini na zuciya. A cikin rauni na zuciya, ikon yin tsayayya da aikin jiki yana ƙaruwa.

A cikin marasa lafiya da ciwon sukari mellitus da nephropathy, shan Lozarel yana tabbatar da kawar da edema.