NovoMix 30 Flexpen: sake dubawa kan aikace-aikacen, umarnin

Takaitawar insulin mutum na matsakaici.
Shiri: NOVOMIX® 30 FlexPen®
Aiki mai guba na miyagun ƙwayoyi: insulin cirewa
Lullukin ATX: A10AD05
KFG: Analog na insulin na mutum na matsakaici tare da farawa da sauri
Lambar yin rijista: P A'a 015640/01
Ranar rajista: 04/29/04
Mai mallaka reg. acc.: NOVO NORDISK A / S

Sakin tsari na Novomiks 30 flekspen, marufin magunguna da abun da ke ciki.

Dakatarwar da aka yi game da kula da launin fari, lokacin da aka sami sassauƙa, ya haifar da fararen farashi da mara launi ko kusan madaukaki mara launi, tare da motsa hankali, ramuwar ɗauka ɗaya.

1 ml
insulin kamar yadda yake guda biyu
CIGABA 100

Wadanda suka kware: mannitol, phenol, metacresol, chloride zinc, sodium chloride, sodium hydrogen phosphate dihydrate, sulfate protamine, sodium hydroxide, acid hydrochloric, ruwa d / da.

* Naúrar 1 ta dace da mcg 35 na insulin na cikin damuwa.

3 ml - alkalami mai sikelin da yawa tare da mai bayar da magani (5) - fakitoci na kwali.

Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.

Aikin magunguna Novomix 30 flekspen

Takaitawar insulin mutum na matsakaici. Yana hulɗa tare da takamaiman mai karɓa a kan ƙwayar cytoplasmic na sel na jikin mutum kuma yana samar da hadaddun insulin-receptor wanda ke motsa ayyukan cikin ciki, gami da kira na enzymes masu yawa (hexokinase, pyruvate kinase, glycogen synthetase). Tasirin hypoglycemic yana da alaƙa da haɓakar jigilar kwayar ciki da haɓaka yawan glucose ta kyallen, haɓakar lipogenesis, glycogenogenesis, da rage raguwar haɓakar glucose ta hanta.

NovoMix 30 Flexpen shine dakatarwa guda biyu wanda ya kunshi insulin aslu mai narkewa (30%) da insulin din kwayar kwayar halitta (70%). Insulin kamar yadda aka samo shi ta hanyar ilimin halittu (a cikin tsarin kwayar insulin, amino acid proline a matsayin B28 an maye gurbinsu da aspartic acid).

Lokacin da aka yi amfani da shi a cikin marasa lafiya da nau'in 1 da nau'in mellitus na sukari na 2, NovoMix 30 FlexPen yana da sakamako iri ɗaya a kan matakin glycosylated hemoglobin kamar insulin bihalsic ɗan adam 30. Insulin aspart da insulin ɗan adam suna da aiki iri ɗaya a cikin molar daidai.

A cikin insulin aspart, musanya amino acid proline a matsayin B28 don aspartic acid yana rage sha'awar kwayoyin don samar da hexamers a cikin narkewa na NovoMix 30 FlexPen, wanda aka lura da insulin na mutum mai narkewa. Dangane da wannan, ana samun insulin aspart daga kitse mai ƙarewa da sauri fiye da insulin mai narkewa wanda yake cikin insulin na ɗan adam. Abubuwan insulin kamar yadda yake aiki, kamar insulin NPH na mutum, ana samun tsawon rai.

Idan aka kwatanta da insulin ɗan adam mai narkewa, ana amfani da insulin (ana ana yin aiki da sauri cikin insulin na mutum) yana farawa da sauri, saboda haka ana iya gudanar da shi nan da nan kafin abinci (daga mintuna 0 zuwa 10 kafin abinci). Sakamakon insulin ruwan kwalliya mai narkewa kamar protamine (analog na matsakaici na ɗan adam na insulin) yana kama da na insulin ɗan adam na NPH. Bayan s / c gwamnatin ta miyagun ƙwayoyi NovoMix 30 Flexpen, sakamakon yana haɓaka bayan minti 10-20. Ana lura da mafi girman tasirin sa'o'i 1-4 bayan allura. Tsawon lokacin da miyagun ƙwayoyi ya kai awanni 24.

Pharmacokinetics na miyagun ƙwayoyi.

Lokacin amfani da NovoMix 30 FlexPen, Cmax na insulin a cikin ƙwayar magani yana kan matsakaicin 50% sama da lokacin amfani da insulin mutum-kashi na mutum 30, yayin da lokacin isa Cmax yana kan matsakaita sau 2 ƙasa da ƙasa. Lokacin da aka ba da magani ga masu sa kai na lafiya a cikin nauyin 0.2 U / kg nauyin jiki, matsakaicin Cmax shine 140 ± 32 pmol / L kuma an kai shi bayan minti 60.

Matsakaicin T1 / 2, yana nuna yawan adadin ƙwayar protamine, yana awoyi 8,9. Yawan maida hankali insulin ya koma matakin sa na 15-18-18 bayan allurar s / c.

A cikin marasa lafiya masu fama da ciwon sukari na 2 na sukari, ana samun Cmax bayan mintuna 95 kuma ana kiyaye shi a matakin da ya fi 0 girma aƙalla awanni 14 bayan gudanarwar sc.

Ba a yi nazarin dogaro da ƙwayar NovoMix 30 FlexPen a kan allurar ba.

Sashi da hanyar gudanar da magani.

Magungunan an yi nufin sc sc. Ba za a iya shigar da miyagun ƙwayoyi NovoMix 30 FlexPen ba / ciki!

An saita kashi-kashi akayi daban-daban bisa alamu na alamomin glucose na jini. Matsakaicin matsakaita na yau da kullun ya tashi daga 0.5 zuwa 1 U / kg nauyin jiki. Tare da juriya na insulin (alal misali, a cikin marasa lafiya masu kiba), ana buƙatar ƙara yawan buƙata na yau da kullun, kuma a cikin marasa lafiya da keɓaɓɓen insulin insulin na insulin, ana iya rage shi.

Ana iya amfani da NovoMix 30 FlexPen a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 na guda biyu ko dai azaman monotherapy ko kuma a haɗe tare da metformin a lokuta inda matakan glucose na jini ba su da isasshen tsari ta hanyar metformin kaɗai. Shafin farko da aka ba da shawarar NovoMix 30 a hade tare da metformin shine 0.2 U / kg / rana. Ya kamata a daidaita sashi gwargwadon buƙatun mutum na insulin, dangane da abubuwan glucose a cikin jini.

Ya kamata a gudanar da NovoMix 30 FlexPen kai tsaye kafin abinci, idan ya cancanta nan da nan bayan abinci. Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya zama zazzabi a ɗakin.

Ana yin allurar s / c a cinya ko bangon ciki, idan ana so - a kafada ko gindi. Wajibi ne a canza wurin allurar a cikin yankin na jiki don hana ci gaban lipodystrophy.

Kamar yadda yake tare da kowane shiri na insulin, tsawon lokacin aikin NovoMix 30 FlexPen ya dogara da kashi, wurin gudanarwa, tsananin zubar da jini, zafin jiki da kuma matakin motsa jiki. Ba a yi nazarin dogaro da ƙwayar NovoMix 30 FlexPen a kan allurar ba.

Dokokin amfani da miyagun ƙwayoyi NovoMix® 30 FlexPen®

Flexpen shine alkalami wanda aka tsara don sarrafa insulin. Ana amfani da Flexpen tare da gajeren allurai NovoFayn. Fakitin gajeren allurai NovoFine alama ce ta S.

Ba zaku iya amfani da NovoMix 30 FlexPen ba, bayan girgizawa, dakatarwar ba ta zama fari da girgije ba gaba ɗaya.

Bai kamata a yi amfani da miyagun ƙwayoyi ba idan farin lumps ya bayyana a ciki ko kuma idan farin barbashi ya tsaya a ƙasa ko bangon kicin, yana ba da bayyanar wanda ya daskararre.

FringPen Syringe Pen na amfanin kai ne kawai kuma ba za'a iya cikawa ba.

Cikakkun shawarwarin don amfani da alkalami na syringe FlexPen ana bayar da su a cikin umarnin likita don NovoMix 30 FlexPen da aka sanya a cikin kowane kunshin.

Sakamakon sakamako na Novomix 30 flekspen:

M halayen da ke tattare da tasirin tasirin metabolism: yawanci hypoglycemia, alamuran wanda zasu iya haɗawa da fatar fatar jiki, gumi mai sanyi, fargaba, rawar jiki, damuwa, gajiya mai rauni ko rauni, rarrabuwar kai, asarar taro, rashi, tsananin yunwar, rauni na gani na ɗan lokaci, ciwon kai, tashin zuciya, tachycardia. Mai tsananin rashin ƙarfi na iya haifar da asarar hankali, ta wani lokaci na wucin gadi ko ba zai iya juyawa ga kwakwalwa da mutuwa.

Allergic halayen: halayen gida (yawancin lokaci na ɗan lokaci kuma tafi yayin da ake ci gaba da jiyya) - redness, busa, itching a wurin allura, yaduwar (barazanar rayuwa) - fatar fata, ƙoshin fata, ƙara yawan shaye shaye, damuwa na ciki, angioedema, wahala numfashi, tachycardia, rage karfin jini.

Sauran: edema, nakuda mai lalacewa (mafi yawa ana lura da shi a farkon aikin insulin kuma suna ɗan lokaci), haɓakar lipodystrophy a wurin allurar.

Contraindications wa miyagun ƙwayoyi:

- increasedara yawan hankalin mutum zuwa insulin kewayawa ko wasu abubuwan maganin.

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin yara da matasa a ƙarƙashin shekara 18, saboda Nazarin asibiti game da amfani da NovoMix 30 Flexpen a cikin marasa lafiya na wannan rukunin shekarun ba a gudanar da su ba.

Yi amfani da lokacin daukar ciki da lactation.

Kwarewar asibiti tare da kewayon insulin a yayin daukar ciki yana iyakance.

A lokacin yiwuwar farawa da kuma tsawon lokacin haila, sanya idanu a hankali game da yanayin marasa lafiya da ciwon sukari da kuma lura da matakin glucose a cikin jini yana da muhimmanci. Bukatar insulin, a matsayin mai mulkin, yana raguwa a cikin farkon farkon kuma a hankali yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam. Jim kaɗan bayan haihuwa, buƙatar insulin da sauri ya koma matakin da ya kasance kafin yin juna biyu.

Yayin shayarwa, ana iya amfani da miyagun ƙwayoyi ba tare da ƙuntatawa ba. Gudanar da insulin ga uwa mai shayarwa ba barazanar ga jariri ba. Koyaya, yana iya zama mahimmanci don daidaita sashi na NovoMix 30 FlexPen.

A cikin nazarin dabbobi na gwaji, ba a sami bambance-bambance tsakanin amfrayo da abubuwan da ke tattare da insulin aspart da insulin na mutum ba.

Umarnin na musamman don amfanin Novomix 30 flekspen.

Rashin isasshen kashi ko dakatar da magani, musamman tare da nau'in ciwon sukari na 1 na mellitus (insulin-dogara), na iya haifar da haɓakar hyperglycemia ko ketoacidosis na ciwon sukari.

Bayyanar cututtukan hyperglycemia yawanci suna haɓaka a hankali a cikin sa'o'i da yawa ko kwanaki kuma sun haɗa da tashin zuciya, amai, amai, ja da bushewar fata, bushewar baki, karuwar fitar fitsari, ƙishirwa da asarar ci, da kuma bayyanar ƙamshin acetone a iska. Idan ba tare da magani da ya dace ba, hauhawar jini na iya haifar da mutuwa.

Bayan ramawa game da metabolism na metabolism, alal misali, tare da ƙwaƙwalwar insulin mai ƙarfi, marasa lafiya na iya fuskantar alamu na yau da kullun na abubuwan da ke faruwa na hypoglycemia, wanda ya kamata a sanar da marasa lafiya game da. A cikin marasa lafiya da masu ciwon sukari tare da ingantaccen kulawa na rayuwa, ƙarshen rikice-rikice na ciwon sukari ya inganta daga baya kuma ci gaba da hankali. A wannan batun, an ba da shawarar aiwatar da ayyukan da aka tsara don inganta sarrafa metabolism, gami da saka idanu kan matakin glucose a cikin jini.

Ya kamata a yi amfani da NovoMix 30 FlexPen a cikin haɗin kai tsaye tare da ɗaukar abinci. Ya kamata kuyi la'akari da babban hanzarin farawar tasirin magunguna a cikin lura da marasa lafiya tare da cututtukan haɗin gwiwa ko shan magunguna waɗanda ke rage yawan shan abinci. A gaban cututtukan concomitant, musamman ma na yanayin cutar, buƙatar insulin yana ƙaruwa. Paarancin nakasar yara ko aikin hepatic na iya haifar da raguwar bukatun insulin.

Ski abinci ko motsa jiki mara tsari na iya haifar da ci gaban haɓakar ƙwanƙwasa. Idan aka kwatanta da insulin mutum na insulin, gudanarwar NovoMix 30 FlexPen yana da tasiri mai ƙarfi na hypoglycemic a cikin 6 na farko bayan gudanarwa. A wannan batun, a wasu yanayi, yana iya zama dole don daidaita sashin insulin da / ko yanayin abincin.

Canja wurin wani mara lafiya zuwa wani sabon nau'in insulin ko kuma shirin insulin wani mai kamfanin dole ne a aiwatar dashi karkashin tsaftataccen aikin likita. Idan kun canza maida hankali, nau'in, masana'anta da nau'in (insulin ɗan adam, insulin dabbobi, analogue na insulin mutum) na shirye-shiryen insulin da / ko hanyar masana'anta, ana iya buƙatar canjin kashi. Marasa lafiya suna canzawa zuwa NovoMix 30 FlexPen na iya buƙatar canjin kashi idan aka kwatanta da insulin da aka yi amfani da shi a baya. Idan ya cancanta, daidaitawa na kashi, ana iya yin riga a farkon allurar ko a farkon makonni ko watanni na jiyya. Bugu da ƙari, ana iya buƙatar canjin kashi na miyagun ƙwayoyi tare da canjin abinci tare da haɓaka aiki na jiki. Yin motsa jiki da aka yi nan da nan bayan cin abinci yana kara haɗarin hawan jini.

Kada ku yi amfani da NovoMix 30 FlexPen a cikin famfo na insulin.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Thearfin marasa lafiya su mai da hankali kuma ana iya rage ƙarfin tashin hankali yayin raunin hypoglycemia da hyperglycemia, wanda zai iya zama haɗari a cikin yanayi inda waɗannan damar ke da mahimmanci musamman (alal misali, lokacin tuki mota ko aiki tare da injuna da injuna). Ya kamata a shawarci marassa lafiya su dauki matakan hana ci gaban hypoglycemia da hyperglycemia yayin tuki mota da aiki da hanyoyin. Wannan yana da mahimmanci musamman ga marasa lafiya da basu da cikakkun alamu na abubuwan ci gaban haila ko kuma fama da yawan cututtukan cututtukan zuciya. A cikin waɗannan halayen, ya kamata a duba yiwuwar irin wannan aikin.

Adadin yawa na miyagun ƙwayoyi:

Bayyanar cututtuka: hypoglycemia na iya haɓaka.

Jiyya: mai haƙuri na iya dakatar da saurin hypoglycemia mai ƙarfi ta hanayar glucose, sukari ko abinci mai-carbohydrate. Sabili da haka, ana ba da shawara ga marasa lafiya da masu ciwon sukari su riƙa ɗaukar sukari, Sweets, cookies ko ruwan 'ya'yan itace mai zaki. A cikin mawuyacin yanayi, idan akwai wani asarar hankali, 40% bayani na dextrose ana allura cikin ciki, glucagon (0.5-1 mg) intramuscularly ko subcutaneously. Bayan ya dawo da hankali, ana ba da shawarar mai haƙuri ya ci abinci mai arzikin carbohydrate don hana sake haɓakar ƙwanƙwasa jini.

Yin hulɗa da Novomix 30 flekspen tare da wasu kwayoyi.

Hypoglycemic mataki da miyagun ƙwayoyi inganta baka hypoglycemic kwayoyi, Mao hanawa, ACE hanawa, carbonic anhydrase hanawa, zabe beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium shirye-shirye ethanol-dauke da shirye-shirye.

Rikicin hypoglycemic na miyagun ƙwayoyi an rage shi ta hanyar hana rigakafi na baka, GCS, shirye-shiryen hodar iblis ta thyroid, thiazide diuretics, heparin, maganin tricyclic antidepressants, juyayi, danazole, clonidine, allunan tashar alli, diazoxide, morphine, phenytoin, nicotine.

A ƙarƙashin rinjayar reserpine da salicylates, duka raunana da haɓaka aikin miyagun ƙwayoyi NovoMix 30 FlexPen yana yiwuwa.

Sharuɗɗan yanayin ajiya na miyagun ƙwayoyi Novomix 30 flekspen.

Jerin B. Babu NovoMix 30 FlexPen ya kamata a adana a cikin firiji a zazzabi na 2 ° zuwa 8 ° C (ba kusa da injin daskarewa ba), kada a daskare. Rayuwar shelf shine shekaru 2.

NovoMix 30 FlexPen da aka yi amfani da shi ya kamata a adana shi a zazzabi da bai wuce 30 ° C ba makonni 4. Don kare daga haske, NovoMix 30 FlexPen ya kamata a rufe tare da hula.

Alamu da contraindications ga amfani da miyagun ƙwayoyi

NovoMix 30 Flexpen an nuna shi don ciwon sukari. Ba a yi nazarin Pharmacokinetics a cikin wadannan rukunan na marasa lafiya:

• tsofaffi
• yara
• marasa lafiya da nakasa da hanta da aikin koda.

Koma dai, bai kamata a yi amfani da magungunan don hypoglycemia ba, tsananin wuce gona da iri ga kayan da ke cikin ko zuwa wani ɓangaren magungunan da aka ƙayyade.

Umarni na musamman da gargadi don amfani

Idan aka yi amfani da rashin isasshen magani ko kuma an daina amfani da magani cikin damuwa (musamman tare da masu ciwon sukari na 1), waɗannan na iya faruwa:

Duk waɗannan yanayin suna da haɗari sosai ga lafiyar kuma suna iya haifar da mutuwa.

Dole ne a gudanar da NovoMix 30 FlexPen ko madadinsa na penfill nan da nan kafin abinci. Wajibi ne a la’akari da farkon farkon wannan aiki na wannan magani a cikin lura da marasa lafiya da ke tattare da cututtukan da ke tattare da cutar ko shan magungunan da za su iya rage yawan abinci a cikin hanji.

Cututtukan rikice-rikice (musamman masu kamuwa da cuta da masu kama da juna) suna ƙara buƙatar ƙarin insulin.

Abinda ke canzawa na mara lafiya zuwa sabon nau'in insulin, abubuwan da suka fara haifar da ci gaban kwayar cutar na iya canzawa sosai kuma sun bambanta da waɗanda suka tashi daga amfani da insulin na yau da kullun. Ganin wannan, yana da matukar muhimmanci a canja mai haƙuri zuwa wasu kwayoyi a ƙarƙashin tsananin kulawa daga likita.

Duk wani canje-canje ya haɗa da daidaitawa da adadin da ake buƙata. Muna magana ne game da irin wannan yanayin:

• canji a cikin taro taro,
• canjin nau'in halitta ko masana'anta,
• canje-canje a cikin asalin insulin (ɗan adam, dabba ko kuma analog na mutum),
• Hanyar gudanarwa ko samarwa.

A kan aiwatar da sauyawa zuwa NovoMix 30 FlexPen insulin injections ko penfill analog injections, masu ciwon sukari suna buƙatar taimakon likita don zaɓin sashi don gudanarwa na farko na sabon magani. Hakanan yana da mahimmanci a cikin makonni na farko da watanni bayan canza shi.

Idan aka kwatanta da insulin na mutum birosus na al'ada, allurar NovoMix 30 FlexPen na iya haifar da mummunan tasirin hypoglycemic. Zai iya ɗaukar har zuwa awanni 6, wanda ya haɗa da sake bitar abubuwan da ake buƙata na insulin ko rage cin abinci.

Ba za a iya amfani da dakatarwar insulin a cikin famfunan insulin don isar da magani a gaba fata ba.

Ikon sarrafa inji

Idan, saboda dalilai daban-daban, hauhawar jini ta haɓaka yayin shan ƙwayoyi, mara lafiya ba zai iya yin cikakken hankali ba kuma ya ba da amsa ga abin da ke faruwa da shi. Saboda haka, tuki mota ko injiniya ya kamata ya iyakance. Kowane mai haƙuri ya kamata ya san matakan da suka wajaba don hana sukarin jini ya sauka, musamman idan kuna buƙatar tuƙi.

A cikin yanayi inda aka yi amfani da FlexPen ko penelill analog ɗin sa, ya zama dole a hankali auna aminci da shawarar tuki, musamman idan alamun rashin ƙarfi na jini ya ɓace ko ba ya nan.

Yaya magungunan ke hulɗa tare da wasu kwayoyi?

Akwai kwayoyi da yawa waɗanda zasu iya shafar metabolism na sukari a cikin jiki, wanda yakamata a yi la’akari da shi yayin ƙididdigar yawan da ake buƙata.

Hanyoyin da ke rage buƙatar insulin na hormone sun haɗa da:

• na baki hypoglycemic,
• MAO masu hanawa
• octreotide
• ACE masu hanawa
• Salamamalla
• anabolics
• sulfonamides,
• barasa mai dauke da
• masu hana masu zabe.

Hakanan akwai kayan aikin haɓaka waɗanda ke buƙatar ƙarin ƙarin amfani da insulin NovoMix 30 FlexPen insulin ko bambance-bambancen penfill:

1. maganin hana haihuwa
2. danazol
3. barasa
4. hakan,
5. GSK,
6. cututtukan mahaifa.

Yadda ake amfani da kashi?

Sashi NovoMix 30 Flexpen mutum ne mai tsayayyen tsari kuma yana bayar da nadin likita, gwargwadon tabbatattun bukatun masu haƙuri. Saboda saurin ƙwayar, dole ne a sarrafa shi kafin abinci. Idan ya cancanta, insulin, har da penfill, yakamata a gudanar dashi jim kadan bayan cin abinci.

Idan muna magana game da alamu na matsakaita, to ya kamata a yi amfani da NovoMix 30 FlexPen gwargwadon nauyin mai haƙuri kuma zai kasance daga 0.5 zuwa 1 UNIT ga kowane kilogram kowace rana. Arin na iya ƙaruwa a cikin waɗanda masu ciwon sukari waɗanda ke da juriya na insulin, da raguwa cikin maganganun abubuwan da ke ɓoye ƙwayoyin jikinsu.

Mafi yawanci ana gudanar da jujjuya inaya a cikin cinya. Hakanan za'a iya shigar da allura a cikin:

• yankin ciki (bango na ciki),
• gindi
• ƙwayar tsoka daga kafada.

Za'a iya guje wa lipodystrophy idan har wuraren da aka nuna sune wuraren da aka allura.

Biye da misalin wasu kwayoyi, tsawon lokacin haɗuwa da miyagun ƙwayoyi na iya bambanta. Wannan zai dogara da:

1. sashi
2. wuraren allura
3. yawan zubar jini
4. matakin aiki na jiki
5. zafin jiki.

Ba'a bincika dolar ruwan sha a wurin allura ba.

Marasa lafiya tare da nau'in ciwon sukari na 2, NovoMix 30 FlexPen (da analog penfill) ana iya tsara su azaman babban jiyya, har ma a hade tare da metformin. Latterarshen ya zama dole a cikin yanayi inda ba zai yiwu a rage taro yawan sukarin jini ta sauran hanyoyin ba.

Yankin da aka ba da shawarar farko na maganin tare da metformin zai zama raka'a 0.2 a kilo kilogram na nauyin haƙuri a rana. Dole ne a daidaita yawan ƙwayar magunguna dangane da buƙatu a kowane yanayi.

Hakanan yana da mahimmanci a kula da matakin sukari a cikin ƙwayar jini. Duk wani aiki na nakasa ko aikin hepatic na iya rage buƙatar hormone.

NovoMix 30 Flexpen ba za'a iya amfani dashi don kula da yara ba.

Za'a iya amfani da maganin da ake tambaya kawai don allurar subcutaneous. Ba za a iya saka shi gabaɗaya cikin jijiya ko a cikin ciki ba.

Bayyanar da mummunan sakamako

Ba za a iya lura da mummunan sakamako game da amfani da miyagun ƙwayoyi ba dangane da canji daga wani insulin ko kuma lokacin canza sashi. NovoMix 30 FlexPen (ko analog penfill ɗinsa) na iya shafar lafiyar lafiyar ƙasa.

A matsayinka na mai mulki, hypoglycemia ya zama mafi yawan lokuta bayyanar cututtuka. Zai iya haɓaka lokacin da sashi ya zarce ainihin ainihin buƙatar hormone, wato, yawan ƙwayar insulin yana faruwa.

Rashin ƙarancin rashin ƙarfi na iya haifar da asarar hankali ko ma rikice-rikice, mai biyowa na har abada ko na wucin gadi na kwakwalwa ko ma mutuwa.

Dangane da sakamakon bincike na asibiti da kuma bayanan da aka rubuta bayan sakin NovoMix 30 a kasuwa, ana iya faɗi cewa abin da ya faru na mummunan ƙwayar cuta a cikin ƙungiyoyi daban-daban na marasa lafiya zai bambanta sosai.

Dangane da yawan abin da ya faru, ana iya raba maganganu marasa kyau cikin mutun gida gida:

• daga tsarin rigakafi: halayen anaphylactic (da wuya sosai), cututtukan ciki, fatar kan fata (wani lokacin),
• game da halayen: itching, matsanancin ji, gumi, rushewa daga cikin narkewa kamar hanzari, saukar jini saukar jini, jinkirin bugun zuciya, angioedema (wani lokacin),
• daga tsarin juyayi: na gefe neuropathies. Haɓakawa da wuri game da kula da sukari na jini zai iya haifar da babban yanayin jijiya mai raɗaɗi, mara jinkiri (da wuya),
• matsalolin hangen nesa: nakasasshen tunani (wani lokacin). Yana da wuri a yanayi kuma yana faruwa a farkon farawar tare da insulin,
• maganin ciwon sukari (wani lokacin). Tare da ingantaccen kulawar glycemic, da alama yiwuwar ci gaban wannan rikitarwa zai ragu. Idan ana amfani da dabarar kulawa mai zurfi, to wannan na iya haifar da fashewar cututtukan fata,
• daga kashin cikin fata da fata, dystrophy na lipid na iya faruwa (wani lokaci). Yana tasowa a waɗancan wuraren da aka yi allura sau da yawa. Likitocin sun bada shawarar canza wurin allurar ta NovoMix 30 FlexPen (ko kuma maganin alkalami) a cikin yankin. Bugu da kari, wuce kima ji na iya farawa. Tare da gabatarwar miyagun ƙwayoyi, haɓakar rashin lafiyar gida zai yiwu: redness, itching fata, kumburi a wurin allurar. Wadannan halayen na lokaci ne na yanayi kuma gaba daya sun lalace tare da ci gaba da magani,
• sauran rikice-rikice da halayen (wani lokacin). Ci gaba a farkon farkon insulin far. Bayyanar cututtuka na ɗan lokaci ne.

Adadin kararraki

Tare da gudanar da mulkin wuce gona da iri na miyagun ƙwayoyi, haɓaka yanayin hypoglycemic mai yiwuwa ne.

Idan matakin sukari na jini ya ragu kaɗan, to za a iya dakatar da ƙin jinin haila ta cin abinci mai daɗi ko glucose. Abin da ya sa ake buƙatar kowane mai ciwon sukari ya ɗauki ƙaramin Sweets, alal misali, giyar da ba ta da ciwon sukari.

Idan akwai rashin wadataccen glucose na jini, lokacin da mara lafiya ya fadi cikin rashin lafiya, to ya zama dole a samar masa da sinadarin intramuscular ko subcutaneous na glucagon a cikin lissafin 0,5 zuwa 1 mg. Umarnin don waɗannan ayyukan ya kamata ya zama sananne ga waɗanda ke zaune tare da ciwon sukari.

Da zaran mai ciwon sukari ya fito daga coma, to yana buƙatar ɗaukar ɗan kalilan da suke ciki. Wannan zai samar da wata dama ta hana fara dawowa.

Ta yaya ya kamata a adana NovoMix 30 Flexpen?

Tabbataccen rayuwar rayuwar ƙwayoyi shine shekaru 2 daga ranar da aka ƙirƙira shi. Jagorar ta bayyana cewa alkalami mai amfani da NovoMix 30 FlexPen (ko alkalami analog dinsa) ba za'a iya ajiye shi a cikin firiji ba. Ya kamata a ɗauka tare da ku a ajiye kuma a adana shi ba don morean makonni 4 a zazzabi da bai wuce digiri 30 ba.

Dole a adana alkalami insulin a cikin digiri 2 zuwa 8. Koma dai yadda ba za ka iya daskare miyagun ƙwayoyi ba!

Tsari sashi:

Bayanin
Homogeneous farin dunƙule-free dakatar. Flakes na iya bayyana a samfurin.
Lokacin da aka tsaya, dakatarwar ta busa, haifar da farin farashi da launin launi ko kusan madaukaki mara launi.
Lokacin haɗuwa da abubuwan da ke cikin alkairin sirinji bisa ga ka'idar da aka bayyana a cikin Umarnin don amfanin likita, dakatarwar da aka yi daidai ya kamata ya tashi.

Propertiesungiyoyin magunguna:

Insulin aspart shine kayan abinci na mutum mai narkewa gwargwadon molar sa.

Rage yawan haɗuwa da glucose a cikin jini yana faruwa ne saboda karuwa a cikin jijiyar jikinta bayan ɗaukar nauyin insulin ga masu karɓar insulin na tsokoki da ƙoshin mai da kuma hana haɓakar glucose ta hanta.

Bayan subcutaneous management na NovoMix® 30 FlexPen®, sakamakon yana haɓakawa tsakanin minti 10-20. Ana lura da mafi girman tasirin a cikin kewayon daga 1 zuwa 4 hours bayan allura. Tsawon lokacin da miyagun ƙwayoyi ya kai awanni 24.

A cikin binciken kwatancen asibiti na wata uku wanda ya haɗa da marasa lafiya da nau'in 1 da nau'in ciwon sukari 2 waɗanda suka karɓi NovoMix® 30 FlexPen® da insulin mutum ɗan adam 30 sau biyu kowace rana kafin karin kumallo da abincin dare, NovoMix® 30 FlexPen® ya nuna rage yawan postprandial maida hankali sosai. jini (bayan karin kumallo da abincin dare).

Nazarin meta na bayanai daga gwaji na asibiti tara da suka shafi marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari 2 sun nuna cewa NovoMix® 30 FlexPen®, wanda ake sarrafawa kafin karin kumallo da abincin dare, yana samar da ingantacciyar iko na yawan zubar jini a cikin jini bayan matsakaici (matsakaicin karuwa a cikin ƙwayar glucose na prandial bayan karin kumallo, abincin rana da abincin dare), idan aka kwatanta da insulin na biphasic na mutum 30. Kodayake yawan kwantar da hankali na glucose a cikin marasa lafiya ta amfani da NovoMix® 30 FlexPen® ya kasance mafi girma, gabaɗaya, NovoMix® 30 FlexPen® yana samar da t Sakamakon guda ɗaya akan taro na glycosylated haemoglobin (HbA_1c), kamar insulin kwayoyin halittar mutum 30.

A cikin binciken asibiti wanda ya shafi marasa lafiya 341 da ke da nau'in ciwon sukari na 2 na marasa lafiya, marasa lafiya sun kasance bazuwar zuwa rukunin jiyya kawai NovoMix® 30 FlexPen®, NovoMix® 30 FlexPen® a hade tare da metformin da metformin a hade tare da wani sinadari na sulfonylurea. HbA taro_1c bayan makonni 16 na magani bai banbanta ga marasa lafiya da ke karɓar NovoMix® 30 FlexPen® a hade tare da metformin kuma a cikin marasa lafiya suna karɓar metformin a hade tare da wani sinadarin sulfonylurea. A cikin wannan binciken, 57% na marasa lafiya suna da babban HbA maida hankali_1c ya kasance sama da 9%, a cikin waɗannan jiyya na marasa lafiya tare da NovoMix® 30 FlexPen® a hade tare da metformin ya haifar da ƙarin raguwa a cikin taro na HbA_1cfiye da marasa lafiya da ke karɓar metformin a hade tare da abin da keɓaɓɓe na tushen sulfonylurea.

A cikin wani binciken, marasa lafiya waɗanda ke da nau'in ciwon sukari na 2 na mara kyau tare da mummunan glycemic sarrafawa waɗanda suka dauki magungunan maganin hypoglycemic na baki sun kasance bazuwar cikin rukunoni masu zuwa: karbar NovoMix® 30 sau biyu a rana (marasa lafiya 117) da karɓar insulin glargine sau ɗaya a rana (marasa lafiya 116). Bayan makonni 28 na amfani da miyagun ƙwayoyi, matsakaiciyar raguwa a cikin taro HbA_1c a cikin rukunin NovoMix® 30 FlexPen®, ya kasance 2.8% (ƙimar matsakaicin farko shine 9.7%). A cikin 66% da 42% na marasa lafiya suna amfani da NovoMix® 30 FlexPen®, a ƙarshen binciken, ƙimar HbA_1c sun kasance ƙasa da 7% da 6.5%, bi da bi. Ma'anar plasma glucose mai azumi ta ragu da kimanin 7 mmol / L (daga 14.0 mmol / L a farkon binciken zuwa 7.1 mmol / L).

Sakamakon nazarin-meta na bayanan da aka samo daga gwaje-gwaje na asibiti wanda ya shafi marasa lafiya da ke da nau'in ciwon sukari na 2 wanda ya nuna raguwa a cikin jimlar cutar nocturnal hypoglycemia da hypoglycemia mai ƙarfi tare da NovoMix® 30 FlexPen® idan aka kwatanta da insulin na ɗan adam na 30. abin da ya faru na rashin lafiyar rana da rana a cikin marasa lafiya da ke karɓar NovoMix® 30 FlexPen® ya kasance mafi girma.

Yara da matasa: An gudanar da gwaji na asibiti na makonni 16 wanda aka kwatanta glucose na jini bayan abinci tare da NovoMix® 30 (kafin abinci), insulin / insulin ɗan adam 30 (kafin abinci) da isofan-insulin (ana sarrafawa kafin barci). Binciken ya shafi marasa lafiya 167 masu shekaru 10 zuwa 18. HbA averages_1c a cikin rukunin biyun sun kasance kusa da ƙimar farko a duk binciken. Hakanan, lokacin amfani da NovoMix® 30 FlexPen® ko insulin mutum ɗan adam 30, babu wani bambance-bambance a cikin yanayin tashin hankali.

An kuma gudanar da binciken kashi-biyu makafi a cikin yawan marasa lafiya wadanda ke tsakanin shekaru 6 zuwa 12 (jimlar marasa lafiya 54, makonni 12 ga kowane nau'in magani). Lalacewar hypoglycemia da karuwa a cikin glucose bayan cin abinci a cikin rukuni na marasa lafiya waɗanda suka yi amfani da NovoMix® 30 FlexPen® sun kasance ƙasa da ƙima idan aka kwatanta da ƙimomin a cikin rukuni na marasa lafiya waɗanda suka yi amfani da insulin na mutum ɗan adam 30. Himar HbA_1c a ƙarshen binciken, a cikin rukuni na aikace-aikacen insulin na mutum bi 30 a cikin ƙasa yana da ƙima sosai fiye da ƙungiyar marasa lafiya da ke amfani da NovoMix® 30 FlexPen®.

Tsofaffi marasa lafiya: Ba a bincika magunguna na NovoMix® 30 FlexPen® na tsofaffi da tsofaffi marasa lafiya ba. Koyaya, a cikin wani binciken da aka yi wanda aka gano mai kashi biyu makafi wanda aka yiwa marassa lafiya guda 19 masu dauke da cutar sankara mai shekaru 2 zuwa 65-83 (yana nufin shekaru 70), likitan likitanci da masana magunguna na insulin ashel da insulin na mutum. Differencesarancin bambance-bambance a cikin magunguna (matsakaicin yawan kumburi glucose - GIR_max yankin kuma ya kasance a karkashin inuwar yawanta na kusan mintuna 120 bayan gudanar da shirye-shiryen insulin - AUC_Girkigir, 0-120 min) tsakanin insulin aspart da insulin na ɗan adam a cikin tsofaffi marasa lafiya sun kasance daidai da waɗanda ke cikin masu sa kai na lafiya da kuma a cikin ƙananan marasa lafiya da ke fama da ciwon sukari mellitus.

Pharmacokinetics
A cikin insulin aspart, musanya amino acid proline a matsayin B28 don aspartic acid yana rage sha'awar kwayoyin don samar da hexamers a cikin narkewa na NovoMix® 30 FlexPen®, wanda aka lura a cikin insulin na mutum mai narkewa. Dangane da wannan, insulin aspart (30%) yana narkewa daga mai mai ƙiba da sauri fiye da insulin mai narkewa wanda yake cikin insulin na ɗan adam. Ragowar 70% ya fadi akan irin kukan da protamine-insulin yake dashi, yawan sha wanda yake daidai yake da na insulin ɗan adam na NPH.

Matsakaicin insulin a cikin jini bayan gudanar da NovoMix® 30 FlexPen® ya zama 50% mafi girma daga insulin na ɗan adam 30, kuma lokacin da za a kai shi rabin shine na insulin na ɗan adam 30. A cikin masu sa kai na lafiya, bayan subcutaneous management na NovoMix® 30 daga lissafin 0.20 IU / kg na nauyin jikin mutum, mafi girman taro na insulin aspart a cikin ƙwayar magani ya samu ne bayan minti 60 kuma ya kasance 140 ± 32 pmol / L. Rabin-rabi (t_1/2) na NovoMix® 30, wanda ke nuna ƙimar karɓar karuwar ƙwayar mahaɗan, ya kasance awoyi 8-9. Matakan insulin matakan sun koma tushe 15 hours bayan subcutaneous management na miyagun ƙwayoyi. A cikin marasa lafiya da ke fama da nau'in ciwon sukari na 2 na sukari, an fi mayar da hankali mafi yawa a cikin mintuna 95 bayan gudanarwa kuma ya kasance sama da tushen aƙalla awanni 14.

Tsofaffi da marasa lafiya marasa lafiya:
Ba a gudanar da nazarin likitan magunguna na NovoMix® 30 na tsofaffi da tsofaffi marasa lafiya ba. Koyaya, bambance-bambance na dangi a cikin pharmacokinetics tsakanin insulin kewayawa da insulin mutum mai narkewa a cikin tsofaffi marasa lafiya da ke da nau'in ciwon sukari na 2 (shekaru 65-83, matsakaicin shekaru - shekaru 70) sun yi kama da waɗanda ke cikin masu sa kai na lafiya da kuma a cikin ƙananan marassa lafiya da ciwon sukari mellitus. A cikin tsofaffi marasa lafiya, an lura da raguwar adadin sha, wanda ya haifar da raguwa a cikin t_max (Mintuna 82 (kewayon tsaka-tsaki: minti 60-120)), yayin da matsakaicin matsakaicin maida hankali C_max ya yi kama da abin da aka lura da shi a cikin matasa marasa lafiya masu fama da ciwon sukari na 2, kuma ɗan ƙasa kaɗan da marasa lafiya da ke ɗauke da ciwon sukari na 1.

Marasa lafiya tare da nakasa na koda da aikin hepatic:
Ba a gudanar da nazarin likitan magunguna na NovoMix® 30 FlexPen® a cikin marasa lafiya da ke fama da rauni na haihuwa da kuma aikin hepatic. Koyaya, tare da karuwa a cikin adadin ƙwayoyi a cikin marasa lafiya tare da bambance-bambancen digiri na ƙananan ƙwayar cuta da aikin hepatic, babu wani canji a cikin kantin magunguna na narkewa insulin cirewa.

Yara da matasa:
Ba a yi nazarin kaddarorin magungunan NovoMix® 30 FlexPen® a cikin yara da matasa ba. Koyaya, an bincika abubuwan da ke cikin magungunan ƙwayoyin magunguna da na magunguna na insulin asulin a cikin yara (shekaru 6 zuwa 12) da matasa (shekaru 13 zuwa 17) tare da nau'in ciwon sukari na 1. A cikin marasa lafiya na duka bangarorin biyu, insulin aspart ya kasance yana nunawa ta hanyar ɗaukar sauri da ƙimar t_maxkama da waɗanda ke cikin manya. Koyaya, dabi'u na C_max A cikin shekaru biyu sun banbanta, wanda ke nuna mahimmancin zaɓin insulin allurai.

Bayanai na Kariyar Haraji
Karatuttukan asibiti ba su bayyana wata haɗari ga ɗan adam ba, gwargwadon bayanai daga binciken da aka yarda da shi gaba ɗaya na lafiyar kimiyyar magunguna, ƙwayar cuta mai maimaituwa, ƙwayar cuta da halayyar haihuwa.

A cikin gwaje-gwajen vitro, wanda ya haɗa da ɗaure wa insulin da masu karɓa na IGF-1 da tasirin ci gaban kwayar halitta, an nuna cewa kadarorin asulin insulin sun yi kama da na insulin ɗan adam. Bincike ya kuma nuna cewa rarraba ɗayan insulin ga masu karɓar insulin daidai yake da na insulin ɗan adam.

Yarjejeniyar:

Yi amfani da lokacin daukar ciki da lokacin shayarwa
Kwarewar asibiti tare da yin amfani da NovoMix® 30 FlexPen® yayin daukar ciki yana iyakatacce.

Ba a gudanar da bincike kan amfani da NovoMix® 30 FlexPen® a cikin mata masu juna biyu ba. Koyaya, bayanai daga gwaji na asibiti guda biyu wadanda aka tsara (bi da bi, 157 da mata masu juna biyu waɗanda suka sami insulin a cikin tsarin kulawa na ƙoshin lafiya) basu bayyana wani mummunan tasirin insulin ba a cikin ciki ko lafiyar tayin / jariri idan aka kwatanta da insulin ɗan adam mai narkewa. Bugu da kari, wani gwaji da aka yi wa likitocin mata 27 wadanda ke dauke da cutar sankarar mahaifa wanda suka sami insulin da kuma insulin jikin mutum (mata 14 sun sami insulin aspart, 13 insulin na mutum) sun nuna alamun amincin iri biyu ga nau'ikan insulin.

A cikin lokacin yiwuwar farawar ciki kuma a duk tsawon lokacinsa, Wajibi ne a lura da yanayin marasa lafiya da ciwon sukari mellitus da saka idanu akan yawan glucose a cikin jini. Bukatar insulin, a matsayin mai mulkin, yana raguwa a cikin farkon farkon kuma a hankali yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Jim kaɗan bayan haihuwa, buƙatar insulin da sauri ya koma matakin da ya kasance kafin yin juna biyu.

Yayin shayarwa, za a iya amfani da NovoMix® 30 FlexPen without ba tare da ƙuntatawa ba. Gudanar da insulin ga uwa mai shayarwa ba barazanar ga jariri ba. Koyaya, yana iya zama mahimmanci don daidaita sashi na NovoMix® 30 FlexPen®.

Sashi da gudanarwa:

Ana amfani da matakin NovoMix® 30 FlexPen® ta likita sau ɗaya a cikin kowane yanayi, daidai da bukatun mai haƙuri. Don cimma ingantaccen matakin ƙwayar cutar glycemia, ana bada shawara don sarrafa yawan kwantar da hankali na glucose a cikin jini da daidaita sashi na maganin.

Marasa lafiya tare da nau'in ciwon sukari na 2 na sukari NovoMix® 30 FlexPen® ana iya tsara su duka biyu azaman maganin monotherapy kuma a hade tare da magungunan maganin hypoglycemic na baki a cikin yanayin inda matakan glucose na jini ba su da izini ta hanyar magunguna na baka kawai.

Ationaddamar da jiyya
Ga marasa lafiya da masu ciwon sukari na nau'in 2 waɗanda aka fara ba su insulin, shawarar farawa ta NovoMix® 30 FlexPen® ita ce raka'a 6 kafin karin kumallo da raka'a 6 kafin abincin dare. Hakanan ana ba da izinin gabatarwar rukunin 12 na NovoMix® 30 Flexpen a sau ɗaya a rana da yamma (kafin abincin dare).

Canza haƙuri daga wasu shirye-shiryen insulin
Lokacin canza mai haƙuri daga insulin mutum na insulin zuwa NovoMix® 30 FlexPen®, yakamata mutum ya fara da kashi ɗaya da yanayin gudanarwa. Don haka daidaita sashi daidai da bukatun mutum na haƙuri (duba shawarwari masu zuwa don titition na kashi na miyagun ƙwayoyi). Kamar yadda koyaushe, lokacin canja wurin mai haƙuri zuwa sabon nau'in insulin, tsananin kulawa na likita ya zama dole yayin canja wurin mai haƙuri kuma a cikin makonni na farko na amfani da sabon magani.

Harkokin rashin lafiya
Ingarfafa hanyoyin kwantar da hankali na NovoMix® 30 FlexPen® mai yiwuwa ne ta hanyar sauyawa daga kashi ɗaya na yau da kullun zuwa ninki biyu. An ba da shawarar cewa bayan isa ga kashi 30 na ragin magani don yin amfani da NovoMix® 30 FlexPen® sau biyu a rana, rarraba kashi zuwa kashi biyu daidai - safe da maraice (kafin karin kumallo da abincin dare).

Sauyawa zuwa amfani da NovoMix® 30 FlexPen® sau uku a rana yana yiwuwa ta hanyar rarraba kashi na safe zuwa sassa biyu daidai da gabatar da waɗannan sassan biyu da safe da kuma abincin rana (sau uku kowace rana).

Gyara daidaitawa
Don daidaita adadin NovoMix® 30 FlexPen®, ana amfani da mafi ƙarancin azumin glucose da aka samu a cikin kwanakin ukun da suka gabata.

Don tantance ƙimar maganin da ya gabata, yi amfani da darajar ƙimar glucose a cikin jini kafin cin abinci na gaba.

Za'a iya yin gyaran fuska sau ɗaya a mako har sai an cimma ƙimar HbA._1c.

Kada ku ƙara yawan ƙwayoyi idan an lura da hypoglycemia a wannan lokacin.

Gyaran matsakaita na iya zama dole yayin da ake inganta ayyukan jikin mai haƙuri, canza yanayin abincinsa na yau da kullun, ko kuma yana da yanayin rashin lafiya. Don daidaita adadin NovoMix® 30 FlexPen®, ana bada shawara don amfani da shawarwarin titration mai zuwa:

Cutar jini ta jini kafin abinci

NovoMix® 30 daidaitawa kashi 10 mmol / l> 180 MG / dl+ Raka'a 6

Groupsungiyoyin haƙuri na musamman
Kamar yadda koyaushe tare da yin amfani da shirye-shiryen insulin, a cikin marasa lafiya na ƙungiyoyi na musamman, yakamata a kula da tattarawar glucose na jini a hankali kuma a daidaita yawan yadda aka raba ɗaki daban-daban.

Tsofaffi da marasa lafiya marasa lafiya:
Ana iya amfani da NovoMix® 30 FlexPen® a cikin tsofaffi marasa lafiya, duk da haka, ƙwarewa tare da amfani dashi a hade tare da magungunan maganganu na bakin jini na marasa lafiya da suka girmi shekaru 75 yana iyakantacce.

Marasa lafiya tare da nakasa na koda da aikin hepatic:
A cikin marasa lafiya da keɓaɓɓen koda ko hepatic kasawa, ana buƙatar rage insulin.

Yara da matasa:
Ana iya amfani da NovoMix® 30 FlexPen® don kula da yara da matasa a cikin shekaru 10 a cikin yanayin inda aka fi son yin amfani da insulin-hade-ins. Akwai ƙarancin bayanan asibiti game da yara masu shekaru 6 zuwa 99 (duba sashin ilimin Magunguna).

NovoMix® 30 FlexPen® ya kamata a gudanar da subcutaneously a cinya ko bangon ciki. Idan ana son, ana iya gudanar da maganin a kafada ko gindi.

Wajibi ne a canza wurin allurar a cikin yankin na jiki don hana ci gaban lipodystrophy.

Kamar yadda yake tare da kowane shiri na insulin, tsawon lokacin aikin NovoMix® 30 FlexPen® ya dogara da kashi, wurin gudanarwa, tsananin zubar da jini, zafin jiki da kuma matakin motsa jiki.

Idan aka kamanta shi da insulin na mutum, NovoMix® 30 FlexPen® ya fara aiki da sauri, saboda haka ya kamata a gudanar dashi kai tsaye kafin abinci. Idan ya cancanta, ana iya sarrafa NovoMix® 30 FlexPen® jim kaɗan bayan cin abinci.

Side sakamako:

A matakin farko na maganin insulin, kurakurai masu narkewa, edema da halayen na iya faruwa a wurin allurar (da suka hada da jin zafi, redness, amya, kumburi, kurma, kumburi da itching a wurin allura). Wadannan alamu yawanci ne na wani lokaci. Ingantaccen haɓakawa cikin kulawar glycemic na iya haifar da yanayin "matsanancin raunin neuropathy," wanda yawanci za'a iya juyawa. Intensation na insulin farjin tare da ingantacciyar ci gaba a cikin sarrafa metabolism na metabolism na iya haifar da lalacewa ta ɗan lokaci a cikin yanayin ciwon sukari, yayin da ci gaba na dogon lokaci a cikin kulawar glycemic yana rage haɗarin ci gaban cututtukan ciwon sukari.

An gabatar da jerin abubuwan sakamako masu illa a cikin tebur.

Dukkanin sakamako masu illa da aka gabatar a ƙasa, dangane da bayanan gwaji na asibiti, an tattara su gwargwadon haɓakar haɓakawa bisa ga tsarin MedDRA da tsarin kwayoyin. Ana bayyana abin da ya haifar da sakamako masu illa kamar: sau da yawa (≥ 1/10), sau da yawa (≥ 1/100 zuwa * Duba “Bayanin halayen mutum masu illa”)

Bayanin raunin halayen mutum ɗaya:
Anafarin kwayoyin
Abubuwan da ke da saurin haifar da yawan tashin hankali (sun haɗa da fashin fata, ƙaiƙayi, ɗumi, damuwar hanji, angioedema, wahalar numfashi, bugun zuciya, raguwar jini), waɗanda ke da haɗari ga rayuwa.

Hypoglycemia
Hypoglycemia shine mafi yawan sakamako masu illa. Zai iya haɓaka idan kashi na insulin yayi yawa sosai dangane da buƙatar insulin. Mai tsananin rashin ƙarfi na iya haifar da asarar hankali da / ko raɗaɗi, wucin gadi ko maye gurbin ayyukan kwakwalwa, har ma da mutuwa. Bayyanar cututtuka na hypoglycemia, a matsayin mai mulkin, yana haɓaka ba zato ba tsammani. Wadannan na iya hadawa da “gumi mai sanyi”, pallor na fata, gajiya mai yawa, tashin hankali ko rawar jiki, damuwa, gajiya ko kasala, rarrabuwar kai, raguwar hankali, nutsuwa, matsananciyar yunwa, hangen nesa, ciwon kai, tashin zuciya, da bugun zuciya. .

Nazarin asibiti ya nuna cewa abin da ke faruwa na hypoglycemia ya bambanta dangane da yawan haƙuri, ƙididdigar dosa, da sarrafa glycemic. A cikin gwaje-gwaje na asibiti, babu wani banbanci a game da yawan abubuwan da ke faruwa a tsakanin jini tsakanin marasa lafiya da ke karbar maganin insulin da kuma marasa lafiya ta hanyar amfani da shirye-shiryen insulin na mutum.

Lipodystrophy
An ba da rahoton maganganun marasa galihu na lipodystrophy Lipodystrophy na iya haɓaka a wurin allurar.

Yawan abin sama da ya kamata

- Marasa lafiya na iya kawar da ciwon sikila mai sauƙi ta hanyar shan glucose ko abinci mai ɗauke da sukari. Sabili da haka, ana ba da shawarar ga marasa lafiya da masu ciwon sukari don ɗaukar samfuran da ke ɗauke da sukari koyaushe.
- Idan akwai haɗarin hypoglycemia mai zafi, lokacin da mara lafiya ya sume, to 0,5 MG zuwa 1 mg na glucagon ya kamata a gudanar dashi cikin intramuscularly ko subcutaneously (wanda aka horar zai iya gudanar da shi) ko kuma maganin glucose mai narkewa (dextrose) (ƙwararren likita ne kawai zai iya gudanar da shi). Hakanan ya zama dole don gudanar da aikin dextrose a cikin ciki idan mara lafiyar bai sake murmurewa minti 10-15 bayan gudanarwar glucagon. Bayan ya murmure, an shawarci mara lafiya ya dauki rubutaccen wadataccen carbohydrate don hana sake dawowa da cutar sikari.

Yin hulɗa tare da wasu kwayoyi

Hypoglycemic sakamako na insulin inganta baka hypoglycemic jamiái, monoamine oxidase hanawa, angiotensin tana mayar enzyme hanawa, carbonic anhydrase hanawa, zabe beta-blockers, bromocriptine, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, kwayoyi lithium salicylates .

Tasirin hypoglycemic na insulin yana raunana ta hanyar maganin hana haihuwa, glucocorticosteroids, hormones thyroid, thiazide diuretics, heparin, maganin tricyclic antidepressants, tausayawa, somatropin, danazole, clonidine, "jinkirin" allunan tashar alli, diazhenotin, morphine.

Beta-blockers na iya rufe alamun bayyanar cututtukan jini.

Octreotide / lanreotide na iya haɓaka da rage buƙatar jiki ga insulin.

Barasa na iya haɓaka ko rage tasirin insulin.

Rashin daidaituwa.
Tunda ba a gudanar da nazarin daidaituwa ba, NovoMix® 30 FlexPen® bai kamata a hade shi da wasu kwayoyi ba.

Kasuwancin magunguna na maganin Novomix 30 flekspen

NovoMix 30 FlexPen wani rashi ne na abubuwa biyu wanda ya kunshi hadewar insulin analogues: insulin aspart (analog na insulin-ɗan adam lokacin aiki) da kuma protamine-insulin aspart (analog na insulin-lokaci na ɗan adam). Rage yawan glucose na jini a ƙarƙashin tasirin insulin kamar yadda yake faruwa bayan ɗaukar mai karɓa na insulin, wanda ke ba da gudummawa ga haɓaka glucose ta tsoka da ƙwayoyin mai kuma lokaci guda yana hana fitowar glucose daga hanta. NovoMix 30 FlexPen dakatarwa ce ta kashi biyu wanda ya kunshi insulin 30% mai narkewa kamar yadda yake aiki. Wannan yana tabbatar da farawa da sauri da sauri idan aka kwatanta da mai narkewa na mutum kuma yana bada damar sarrafa magani nan da nan kafin abinci (daga mintuna 0 zuwa 10). Tsarin kukan (70%) yana kunshe da protamine-insulin aspart, bayanin ayyukan wanda yake daidai yake da matsayin tsaka tsaki na mutum-proulinine-insulin Hagedorn (NPH).NovoMix 30 FlexPen yana farawa minti 10-20 bayan allurar sc. Ana samun tasirin sakamako mai yawa 1-4 bayan aiki. Tsawon lokacin aiki har zuwa awanni 24.
Matsayi na glycosylated haemoglobin a cikin marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2 wanda aka gudanar da NovoMix 30 na watanni 3, daidai yake da lokacin da ake gudanar da insulin na mutum. Lokacin da aka sarrafa allurai iri daya, insulin aspart ya dace da aikin insulin mutum. A cikin nazarin asibiti, marasa lafiya da ke da nau'in ciwon sukari na II II (mutane 341), sun kasu kashi biyu bisa tsarin da aka tsara, sun sami NovoMix 30 FlexPen, ko NovoMix 30 FlexPen a hade tare da metformin, ko metformin a hade tare da sulfonylurea. Bayan makonni 16 na jiyya, dabi'un glycosylated hemoglobin НbА1с a cikin marasa lafiya da suke karɓar NovoMix 30 a hade tare da metformin ko metformin a hade tare da sulfonylurea iri daya ne. A cikin wannan binciken, a cikin 57% na marasa lafiya, matakin HbA1c ya fi 9% girma. A cikin waɗannan marasa lafiya, haɗuwa da NovoMix 30 FlexPen da metformin sun haifar da raguwar bayyanar da ƙimar HbA1c idan aka kwatanta da haɗuwa da metformin da sulfonylurea.
A cikin nazarin nau'ikan masu ciwon sukari na II a cikin wane sarrafawa
glycemia da na baka hypoglycemic kwayoyi
ya tabbatar da rashin inganci, an bi da shi tare da gabatarwar miyagun ƙwayoyi
NovoMix 30 sau biyu a rana (marasa lafiya 117) ko ta hanyar gudanarwa
insulin glargine sau daya a rana (marasa lafiya 116). Bayan makonni 28
jiyya tare da NovoMix 30, tare da shi
zaɓi na allurai, matakin HbA1c ya ragu da 2.8% (matsakaita
HbA1c dabi'u yayin da aka haɗa su a cikin binciken = 9.7%). A yayin jiyya tare da NovoMix 30, matakan HbA1c da ke ƙasa 7% sun kai 66% na marasa lafiya, kuma a ƙasa da 6.5% - 42% na marasa lafiya,
wannan azumi plasma maida hankali ne ya ragu
kamar 7 mmol / l (daga 14.0 mmol / l kafin jiyya - har zuwa 7.1
mmol / l).
Pharmacokinetics. A cikin insulin, a gefe, amino acid proline a matsayi na 28 na sarkar na sarkar insulin ana maye gurbinsu da aspartic acid, wanda zai rage samuwar hexamers da aka kirkira a cikin shirye-shiryen insulin na mutum. A cikin lokaci mai narkewa na NovoMix 30 FlexPen, yawan insulin aspart shine 30% na duk insulin. Ya kasance cikin jini daga ƙwayar subcutaneous da sauri fiye da insulin na insulin na mutum. Sauran kashi 70% na lissafin ne ta hanyar kukan da protamine-insulin aspart, wanda yawan shansa yayi daidai da na NPH na mutum.
Matsakaicin yawan insulin a cikin ƙwayar jini bayan gudanarwar NovoMix 30 Flexpen shine 50% mafi girma, kuma lokacin da za a kai shi shine rabin insulin na ɗan adam mai ƙwaƙwalwa 30. A cikin masu sa kai na lafiya, bayan sc gudanar da NovoMix 30 a cikin 0.20 U / kg mafi girman taro na insulin kewayawa a cikin magani ya samu bayan minti 60 kuma ya kasance 140 ± 32 pmol / L. Rabin rayuwar NovoMix 30, wanda ke nuna adadin yawan shan kwayar protamine, ya kasance awanni 8-9. Matsayin insulin a cikin jijiyar jini ya koma asalin 15-18 na asali bayan tafiyar s / c. A cikin marasa lafiya da nau'in ciwon sukari na II II mellitus, mafi girman taro ya kai minti 95 bayan gudanarwa kuma ya kasance sama da matakin farko na akalla awanni 14.
Yara da matasa.
Ba a bincika magunguna na NovoMix 30 FlexPen a cikin yara da matasa ba. Koyaya, a cikin yara (shekaru 6-12) da matasa (13-17 years) tare da nau'in ciwon sukari na 1, an yi nazarin kan magunguna da kuma magunguna na insulin insulin. Ya kasance cikin hanzari a cikin marasa lafiya na ɓangarorin biyu, yayin da dabi'u don lokacin don isa mafi yawan maida hankali daidai suke da na manya. A lokaci guda, dabi'un Cmax a cikin rukuni daban daban sun bambanta sosai, wanda ke nuna mahimmancin zaɓi ɗaya na allurai na allurai.
Ba a yi nazarin magunguna na NovoMix 30 ba a cikin daidaikun mutane.
tsofaffi, yara da marasa lafiya da ke fama da rauni
koda ko hanta.

Zaɓin wani kashi na NovoMix 30

141-180 mg / 100 ml

Ya kamata ku mai da hankali ga mafi ƙasƙantar taro a cikin kwanakin nan ukun da suka gabata. Idan da akwai abubuwan da ke faruwa a cikin jini a cikin wannan lokacin, to yawan kwayoyin cutar insulin ba shi da yawa. Ana yin zaɓin sashi sau ɗaya a mako har sai an kai matakin HbA1c. Abubuwan da ke tattare da kwantar da hankali na glucose kafin abinci su tantance ƙimar kashi na baya.
Ciwon hanta ko aikin koda na iya rage buƙatuwar insulin.
Ana iya amfani da NovoMix 30 Flexpen a cikin yara da matasa masu shekaru 10 da haihuwa, idan aka zaɓi gabatar da cakuda insulin. Bayanai daga nazarin asibiti game da amfani da miyagun ƙwayoyi a cikin yara masu shekaru 6-9 masu shekaru suna iyakance. Ba a gudanar da karatun yara a cikin yara masu shekaru 6 ba.
Ana iya amfani da NovoMix 30 FlexPen a cikin tsofaffi marasa lafiya, duk da haka, ƙwarewar amfani da shi a haɗe tare da PSS a cikin mutane sama da shekaru 75 yana da iyaka.
Babu dalilin da ya kamata a gudanar da NovoMix 30 FlexPen iv.
Umarnin don amfani da miyagun ƙwayoyi NovoMiks 30
Sauke haƙuri ga mai haƙuri
Ya kamata a jaddada mahimmancin haɗuwa sosai.
dakatar da insulin kafin amfani. Bayan motsawa
Dakatarwar ya kamata ya kasance fari da kuma girgije .. NovoMix 30 FlexPen anyi shi ne don amfanin mutum kawai.
Karka sake cika NovoMix 30 FlexPen.
Ana amfani da NovoMix 30 FlexPen tare da allurar gajeren novoFine®.
Kafin amfani da NovoMix 30
Flekspen: ya wajaba a bincika alamar don daidai nau'in insulin da aka yi amfani dashi. Koyaushe yi amfani da sabon allura don kowane allura.
Kada kayi amfani da NovoMix 30 FlexPen:

• a cikin famfo na insulin,
• idan an sa firinji na FlexPen, idan ya lalace ko maras kyau, kamar yadda a cikin waɗannan yanayin insulin na iya zubowa,
• idan ba a adana alkairin sirinji yadda yakamata ba ko ya zama mai daskarewa, idan bayan motsawar dakatarwar ba ta zama fari da girgije ba, idan farin ƙyallen ko ƙaramin farin kwalliyar ya bayyana a cikin shiri, yana manne wa ƙasa ko bangon kicin, yana ba da bayyanar mai daskarewa.

NovoMix 30 Flexpen an tsara shi don allurar SC.
Ba za a iya shigar da miyagun ƙwayoyi cikin / ciki ko kai tsaye cikin tsoka ba.
Don hana samuwar infiltrates, shafin allurar ya kamata a canza koyaushe. Mafi kyawun wurare don gudanarwa shine bango na ciki, gindi, saman cinya ko kafada. Ayyukan insulin yana faruwa da sauri lokacin allura zuwa cikin kugu.

Sakamakon sakamako na miyagun ƙwayoyi Novomix 30 flekspen

Abubuwan da ba a sani ba sun lura a cikin marasa lafiya da ke amfani da NovoMix 30 FlexPen suna da alaƙa da girman sashi na magunguna kuma alama ce ta aikin magunguna na insulin. Sakamakon mafi yawan gefen maganin insulin shine hypoglycemia. Zai iya faruwa idan kashi ya wuce mahimmancin haƙuri ga insulin. Mai tsananin rashin ƙarfi na iya haifar da asarar hankali da / ko raɗaɗi, sakamakon rashi na ɗan lokaci ko na dindindin na kwakwalwa har ma da mutuwa. Dangane da sakamakon bincike na asibiti, kazalika da bayanan da aka rubuta bayan an ƙaddamar da miyagun ƙwayoyi a kasuwa, kasancewar yanayin rashin ƙarfi na jini ya bambanta a cikin ƙungiyoyi daban-daban na marasa lafiya kuma tare da tsarin magunguna daban-daban, abin da ya haifar da mummunan rashin ƙarfi a cikin marasa lafiya da ke karɓar insulin kamar yadda yake a cikin waɗanda ke karɓar ɗan adam insulin
Mai zuwa shine mitar halayen masu illa wanda, bisa ga karatun asibiti, na iya alaƙa da gabatarwar miyagun ƙwayoyi NovoMix 30 Flexpen.
Dangane da yawan aukuwar lamarin, waɗannan halayen sun kasu kashi biyu wani lokacin (1/1000, ≤1 / 100) da da wuya (1/10 000, ≤1 / 1000). Wasu lokuta mara kan gado an dangana su da wuya (≤1/10 000).
Daga tsarin rigakafi
Da wuya halayen anaphylactic.
Wasu lokuta: urticaria, itching, fatar fata.
Abubuwan da ke tattare da tsinkaye a jiki na iya hadawa da fatar fatar jiki, cuncushi, gumi, hargitsi ciki, angioedema, gajeriyar numfashi, bugun zuciya da rage karfin jini. Waɗannan halayen suna iya yin barazanar rayuwa.
Daga tsarin juyayi
Koma: na gefe neuropathies. Ingantaccen haɓakawa a cikin kulawar glucose na jini na iya haifar da matsanancin raunin neuropathy, wanda yawanci lokaci ne.
Vioarya ta sashin hangen nesa
Wasu lokuta: tashin hankali na shakatawa, na iya faruwa a farkon farawar insulin kuma sun kasance wuri na lokaci.
Wasu lokuta: maganin ciwon sukari. Dogon lokacin kulawa da kyawun kulawa na glycemic yana rage haɗarin ci gaban cututtukan cututtukan zuciya. Koyaya, ƙarawar ƙwayar insulin don hanzarta inganta ƙwayar glycemic na iya haifar da haɓaka ɗan lokaci na ciwon sukari na retinopathy.
A wani ɓangaren fata da ƙwaƙwalwar fata
Wasu lokuta: lipodystrophy, na iya faruwa a cikin wuraren allurar sakamakon rashin bin ka'idodi da shawarar don canza wurin allurar a cikin yankin guda ɗaya, rashin lafiyar gida. Lokacin da aka allura insulin, zazzabin cikin gida na iya faruwa (redness, busa, da itching a wurin allurar). Wadannan halayen suna ba da jimawa ba kuma sun gushe tare da ci gaba da magani.
Rage rikicewa da halayen a wuraren allura
Wasu lokuta: Edema na gida, na iya haɓaka a farkon farawar insulin. Wadannan alamu yawanci lokaci ne.

Umarnin na musamman don amfanin kwayar Novomix 30 flekspen

Adearancin kuzari ko dakatar da magani (musamman tare da nau'in ciwon sukari na mellitus na I) na iya haifar da hyperglycemia da ketoacidosis na ciwon sukari, waɗannan yanayin suna da haɗari.
Marasa lafiya waɗanda suka inganta mahimmancin matakan glucose na jini, alal misali saboda kulawa mai zurfi, na iya lura da canji a alamuransu na yau da kullun - abubuwan da ke haifar da ciwon sikila, wanda yakamata a faɗakar da marasa lafiya a gaba.
Ya kamata a gudanar da NovoMix 30 FlexPen kai tsaye kafin abinci. Ya kamata a yi saurin fara amfani da miyagun ƙwayoyi a cikin lura da marasa lafiya da cututtukan da ke tattare da haɗari ko shan magunguna waɗanda zasu iya rage yawan shan abinci a cikin narkewa. Cututtukan haɗin gwiwa, musamman cututtukan zazzabi da zazzabi, suna ƙara buƙatar haƙuri ga insulin. Lokacin canja mai haƙuri zuwa wasu nau'in insulin, alamun gargaɗin farkon suna iya canzawa ko ƙarancin shela fiye da lokacin shan lokacin insulin na yau da kullun. Canjin mai haƙuri zuwa wani nau'in ko nau'in insulin ana aiwatar dashi a ƙarƙashin kulawar likita. Canje-canje a cikin natsuwa, nau'in (masana'anta), nau'in, asalin insulin (dabba, ɗan adam ko ƙimar insulin mutum) da / ko hanyar samarwa na iya buƙatar daidaita yanayin. Lokacin canzawa zuwa injections na NovoMix 30 FlexPen, marasa lafiya na iya buƙatar canza sashin da aka saba da insulin. Bukatar zaɓin kashi na iya tashi duka a lokacin farkon sabon magani, da kuma a farkon fewan makonni ko watanni na amfani.
Cire abinci, canji na abinci kwatsam, ko mummunan aiki na jiki wanda ba a tsammani ba zai iya haifar da rashin lafiyar jiki. Idan aka kwatanta da insulin na ɗan adam insulin, allurar NovoMix 30 FlexPen tana haifar da tasirin sakamako mai hauhawar jini, wanda zai iya ɗaukar tsawon awa 6. Wannan na iya buƙatar zaɓi zaɓi na allurai insulin da / ko abinci.
Bukatar zaɓin kashi na iya faruwa tare da
increasedara yawan aiki a jiki ko canji a abinci. Yin motsa jiki kai tsaye bayan cin abinci yana kara haɗarin cutar hawan jini.
Kada a yi amfani da dakatarwar insulin a cikin famfunan insulin don ci gaba da gudanar da aikin insulin.
Lokacin daukar ciki da lactation. Kwarewar asibiti tare da kewayon insulin a yayin daukar ciki yana iyakance. Nazarin dabbobi sun nuna cewa insulin aspart, kamar insulin ɗan adam, ba shi da amfanuwa da tasirin teratogenic. Recommendedara yawan kulawa yana bada shawarar a lura da mata masu juna biyu da masu ciwon siga a duk tsawon lokacin da suke ciki, da kuma a lokuta da ake zargin suna da juna biyu. Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma yana ƙaruwa sosai a cikin watanni na biyu da na uku. Bayan haihuwa, buƙatar insulin da sauri ya koma tushe. Hakanan babu wasu hani game da lura da ciwon sukari mellitus tare da insulin yayin shayarwa, tun da kulawa da mahaifiyar mai reno ba ta haifar da haɗari ga jariri. Koyaya, yana iya zama mahimmanci don daidaita sashi na NovoMix 30 FlexPen.
Tasiri kan iya tuka motoci da abubuwan aiki. Amsar mai haƙuri da iyawar sa na iya mai da hankali na iya kasancewa yana illa tare da cututtukan jini. Wannan na iya zama haɗari ga yanayi yayin da waɗannan iyawar ke da mahimmanci musamman (alal misali, lokacin tuki mota ko sarrafa kayan inji).
Ya kamata a shawarci marasa lafiya su dauki matakan hana hypoglycemia kafin tuki. Wannan yana da mahimmanci musamman ga waɗanda ke da rauni ko bayyanar cututtuka - abubuwan da ke faruwa a cikin abubuwan da ke faruwa a cikin hypoglycemia suna faruwa akai-akai. A karkashin irin wannan yanayi, yakamata a auna nauyi da amincin tuki.

Abun hulɗa da miyagun ƙwayoyi Novomix 30 flekspen

Yawancin kwayoyi suna shafar metabolism metabolism, wanda yakamata a yi la’akari da shi yayin ƙayyade adadin insulin.
Magunguna waɗanda ke rage buƙatar insulin: wakilan hypoglycemic na bakin jini, octreotide, MAO inhibitors, masu hana β-adrenergic recepor blockers, ACE inhibitors, salicylates, barasa, anabolic steroids da sulfonamides.
Magunguna waɗanda ke kara buƙatar insulin: maganin hana haihuwa, thiazides, corticosteroids, hormones thyroid, sympathomimetics da danazole. Ckers-adrenergic blockers na iya rufe alamun hypoglycemia, barasa na iya haɓakawa da tsawaita tasirin hypoglycemic na insulin.
Rashin daidaituwa. Additionarin wasu magunguna zuwa insulin na iya haifar da lalata, alal misali, kwayoyi waɗanda ke ɗauke da baƙin jini ko sulfites. NovoMix 30 Flexpen ba za a iya ƙara zuwa mafita jiko ba.

Doaukar hoto na Novomix 30 flekspen, alamu da magani

Kodayake babu takamammen ma'anar yawan wuce haddi don insulin, ƙwanƙwasa jini na iya haɓakawa tare da sarrafa yawanta.
Rashin tsabtataccen jini shine tsayayyen jini da abinci mai zaki. Sabili da haka, ana ba da shawara ga marasa lafiya da ciwon sukari su ɗauka sau da yawa guda na sukari, alewa, kukis ko ruwan 'ya'yan itace mai zaki.
A cikin hypoglycemia mai tsanani, lokacin da mai haƙuri bai san komai ba, ya zama dole don aiwatar da v / m ko s / c injections na glucagon (daga 0.5 zuwa 1 MG), ta hanyar mutumin da ya karbi umarnin da ya dace. Kwararren likita kuma yana iya gudanar da maganin glucose na mara lafiya a cikin mara lafiya kuma idan mara lafiyar bai amsa aikin glucagon a tsakanin mintina 10-15 ba.
Bayan mai haƙuri ya sake farfaɗo, ya kamata ya ɗauki carbohydrates a ciki don hana sake dawowa daga hypoglycemia.

Yanayin ajiya na miyagun ƙwayoyi Novomix 30 flekspen

Rayuwar shelf shine shekaru 2.
Amfani bai kamata a adana alkairin sirinji tare da NovoMix 30 FlexPen ba a cikin firiji. Ya kamata a adana alkalami mai sirinji, wanda aka yi amfani da shi ko aka ɗauke shi tare da ku, amma ya kamata a adana shi bai wuce mako 4 ba (a zazzabi da bai wuce 30 ° C ba).
Ba a Amfani ya kamata a adana alkairin sirinji tare da NovoMix 30 FlexPen a cikin firiji a zazzabi na 2-8 ° C (ba kusa da injin daskarewa ba). Kar a daskare. Don kiyayewa daga tasirin haske, adana sirinji mai kaɗa tare da hula a kunne.

Jerin kantin magunguna inda zaku iya siyan Novomix 30 flekspen:

Mai masana'anta:

Wakilin
Novo Nordisk A / S
119330, Moscow,
Lomonosovsky Prospekt 38, ofis 11

Umarnin don marasa lafiya akan amfani da NovoMix® 30 FlexPen® Da fatan za a karanta waɗannan umarni a hankali kafin amfani da NovoMix® 30 FlexPen®
NovoMix® 30 FlexPen® shine allon insulin na musamman da mai saurin wutan lantarki. Matsayin insulin wanda aka gudanar, wanda ya fara daga raka'a 1 zuwa 60, za'a iya canza shi a cikin yawan rukunin 1. NovoMix® 30 FlexPen® an tsara don amfani dashi tare da allurar disposite NovoFayn® ko NovoTvist® har zuwa 8 mm tsayi. A matsayin kiyayewa, koyaushe ka ɗauki tsarin sauyawa na insulin wanda idan ka rasa ko ka lalata NovoMix® 30 FlexPen®.

Shirye-shiryen NovoMix® 30 FlexPen®
Duba tambarin don tabbatar da cewa FlexPen® naka ya ƙunshi nau'in insulin da ya dace. Kafin allurar farko, haxa insulin:

A
Don sauƙaƙe haɗuwa, ba da damar ƙwayoyi don dumama zuwa zafin jiki na ɗakin. Cire kwalkwali daga alkairin sirinji.

A
Mirgine alkalami a tsakanin tafin hannu sau 10 - yana da mahimmanci cewa yana cikin daidaituwa.

Tare da
Liftaga maɓallin sirinji sama da ƙasa sau 10, kamar yadda aka nuna a cikin hoto C, saboda ƙwallon gilashi ya motsa daga ƙarshen katif ɗin zuwa ɗayan. Maimaita ayyukan da aka kayyade a cikin maki B da C har sai abubuwan da ke cikin katun sun zama fari fat da girgije.
Kafin kowane allura mai zuwa, haɗa abin da ke ciki kamar yadda aka nuna a cikin hoto C aƙalla sau 10 har sai abubuwan da ke cikin katun sun kasance fari da shuɗi. Bayan an gauraya, nan da nan sai a yi allura.

Koyaushe tabbatar cewa aƙalla raka'a insulin 12 a cikin katun don tabbatar da haɗuwa ɗaya. Idan kasa da raka'a 12 suka rage, yi amfani da sabon NovoMix® 30 FlexPen®.

Abubuwan da aka makala

D
Cire kwali na kariya daga allura wanda za'a iya cirewa. Fitar da allura a hankali da tam a kan NovoMix® 30 FlexPen®.

E
Cire maɓallin kyallen da ke cikin allura, amma kada a jefar da shi.

F
Cire ka zubar da kwarin ciki na allura.