Humulin® M3 (Humulin® M3)

Sunan kasuwanci na shirye-shiryen: HUMULIN ® Regular

Sunan kasa da kasa mai zaman kanta (INN):
Matsalar insulin (aikin injin dan adam)

Form sashi
Magani don allura

Abun ciki
1 ml ya ƙunshi:
abu mai aiki - insulin mutum 100 IU / ml,
magabata: metacresol, glycerol (glycerin), ruwa don allura, maganin hydrochloric acid 10% da / ko sodium hydroxide bayani 10% za'a iya amfani dasu a cikin masana'antar don kafa pH.

Bayanin
Maganin amintaccen bayani mara launi.

Rukunin Magunguna
Ma'aunin hypoglycemic shine insulin-gajeren aiki.

Lambar ATX A10AB01.

Kayan magunguna
Pharmacodynamics
Humulin ® Na yau da kullun shine insulin kwayar halittar jikin ɗan adam. Babban aikin insulin shine tsari na metabolism metabolism. Bugu da kari, yana da tasirin maganin anabolic da anti-catabolic akan nau'ikan nama daban daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.
Humulin ® Regular wani shiri ne na insulin gajere. Farawar aikin miyagun ƙwayoyi shine minti 30 bayan gudanarwa, mafi girman tasirin shine tsakanin 1 da 3 hours, tsawon lokacin aikin shine awanni 5-7. Bambancin mutum a cikin aikin insulin ya dogara da dalilai kamar kashi, zaɓin wurin allura, ayyukan jiki na mara haƙuri, da dai sauransu.

Pharmacokinetics
Cikakken kamfani da kuma haifar da tasirin insulin ya dogara da wurin allura (ciki, cinya, buttocks), kashi (girman insulin allurar), yawan insulin a cikin magunguna, da dai sauransu An rarraba shi ba tare da bambanci ba a jikin kyallen, kuma ba ya shiga cikin shinge na mahaifa da kuma cikin madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya fitar da ita (kashi 30-80%).

Tsarin ilimin rayuwa (ICD-10)

Sashi da gudanarwa

S / c zuwa kafada, cinya, gindi ko ciki. An ba da izinin gudanar da intramuscular.

Girman Humulin ® M3 likita ne ya ƙaddara shi daban-daban, gwargwadon yawan glucose a cikin jini. A / a cikin gabatarwar miyagun ƙwayoyi Humulin M3 an contraindicated.

Zazzabi na miyagun ƙwayoyi da aka sarrafa ya kamata ya kasance da zazzabi a ɗakin. Dole ne a sauya wuraren allurar don kada a yi amfani da wurin iri ɗaya ba kusan sau ɗaya a wata ba. Tare da kulawar s / c na insulin, dole ne a kula da kar a shigar da jini. Bayan allurar, bai kamata a sanyaya wurin da allura ba.

Yakamata a horar da marassa lafiya yadda yakamata ayi amfani da na’urar insulin.

Humulin ® M3 wani gurbi ne wanda aka shirya tare da takamaiman abun ciki na Humulin ® Regular da Humulin ® NPH, an shirya su don guje wa buƙatar haɗuwa da shirye-shiryen insulin ta marasa lafiya da kansu. Tsarin sarrafa insulin shine mutum ɗaya.

Shiri don gabatarwa

Don shirye-shiryen Humulin ® M3 a cikin vials. Nan da nan kafin amfani, vials na Humulin ® M3 dole ne a yi birgima a cikin tafin hannu sau da yawa har sai an sake yin insulin har sai ya zama ruwan da aka sani ko madara. Shake da ƙarfi, kamar yadda wannan na iya haifar da kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi. Kada kuyi amfani da insulin idan ya ƙunshi flakes bayan haɗuwa ko farin barbashi mai laushi da ke ƙasa ko ganuwar vial, yana haifar da sakamakon yanayin yanayin sanyi. Yi amfani da sirinji na insulin wanda ya dace da yawan insulin allura.

Don shirye-shiryen Humulin ® M3 a cikin katako. Nan da nan kafin amfani, Humulin ® M3 katunan ya kamata a birgima tsakanin tafin hannu har sau goma kuma girgiza, juya 180 ° kuma sau goma har sai insulin ya sake tahowa har sai ya zama ruwan da ya zama ruwan sanyi ko madara. Shake da ƙarfi, kamar yadda wannan na iya haifar da kumfa, wanda zai iya tsoma baki tare da madaidaicin kashi. A cikin kowane katifa akwai ƙaramar ƙaramar gilashin da ke sauƙaƙe haɗuwa da insulin. Kina amfani da insulin idan yana dauke da flakes bayan an gauraya. Na'urar katuwar katako ba ta bada izinin haɗa abubuwan da ke cikin su tare da wasu abubuwan insulins kai tsaye a cikin katun da kanta. Ba a cika cika abubuwan alaƙar katako ba. Kafin allurar, ya wajaba don sanin kanka tare da umarnin mai ƙira don amfani da alkalami mai narkewa don gudanar da insulin.

Don Humulin ® M3 a cikin QuickPen ™ Syringe Pen. Kafin yin allura, ya kamata ka karanta QuickPen ™ Syringe Pen Umarnin don Amfani.

Jagorar Alƙawuri na QuickPen.

QuickPen ™ Syringe Pen yana da sauƙin amfani. Na'ura ce don gudanar da insulin (“insulin alkalami”) mai ɗauke da 3 ml (300 PIECES) na shirin insulin tare da aiki na 100 IU / ml. Kuna iya shiga daga raka'a insulin 1 zuwa 60 a allura. Zaka iya saita kashi tare da daidaitaccen raka'a ɗaya. Idan an kafa sassan da yawa, ana iya gyara kashi ba tare da asarar insulin ba. Ana bada shawarar QuickPen e Syringe Pen don amfani da allurar samarwa Becton, Dickinson da Kamfanin (BD) don alkairin sirinji. Kafin yin amfani da alkairin sirinji, tabbatar cewa allura ta kasance a haɗe da alkalami na syringe.

A nan gaba, yakamata a bi ƙa'idodin masu zuwa.

1. Bi dokokin asepsis da maganin antiseptics da likitanku ya ba ku.

3. Zaɓi wurin yin allura.

4. Shafa fata a wurin allurar.

5. Madadin wuraren allurar don kada a yi amfani da wurin iri ɗaya fiye da sau ɗaya a wata.

Shiri da Gabatarwa na QuickPen ™ Syringe Pen

1. capaga maɓallin murfin sirinji don cire shi. Kar a juya hula. Kar a cire tambarin daga alkalami na syringe. Tabbatar an bincika insulin don irin insulin, ranar karewa, bayyanar. A hankali mirgine sirinji sau 10 tsakanin tafin hannun kuma jujjuya sau 10.

2. newauki sabon allura. Cire kwalin takarda daga saman kwalbar allura. Yi amfani da kayan maye wanda za a shafa diski na roba a ƙarshen abin riƙe da keken. Haɗa allura dake cikin hula, allally, zuwa alkalami na ƙwanƙwasa. Yi dunƙule akan allura har sai an haɗa shi cikakke.

3. Cire madancin daga allura. Kada ku jefa shi. Cire kwalban ciki na allura kuma ka watsar da shi.

4. Duba QuickPen ™ Syringe Pen don insulin. Kowane lokaci ya kamata ku bincika shan insulin. Tabbatar da isar da insulin daga alkairin sirinji yakamata a yi kafin kowane allura har sai tarin asulin ya bayyana don tabbatar da cewa alkalami na shirye don kashi.

Idan baka bincika cin insulin ba kafin tarkon ya bayyana, zaku iya samun insulin kadan ko yayi yawa.

5. Gyara fata ta cire shi ko tara ta a babban falo. Saka allurar sc ta amfani da allurar da likitan ka ya ba da shawarar ka. Sanya yatsan yatsa akan maɓallin kashi kuma latsa da tabbaci har sai ya daina gaba ɗaya. Don shigar da cikakken kashi, riƙe maɓallin kashi kuma sannu a hankali ƙidaya zuwa 5.

6. Cire allura kuma a hankali matsi wurin da allura ta auduga da auduga na da yawa na dan lokaci. Kar a shafa wurin allurar. Idan insulin ta sauka daga allura, wataƙila mara lafiya bai riƙe allurar a ƙarƙashin fata ya ishe shi ba. Kasancewar digo na insulin a saman allurar al'ada ce, ba za ta cutar da sashi ba.

7. Amfani da abin kaɗa allura, ɓoye allura kuma zubar dashi.

Hatta lambobi ana bugawa a taga alama kamar lamba, lambobi m azaman madaidaitan layi tsakanin lambobi.

Idan kashi da ake buƙata na aikin gwamnati ya wuce adadin raka'o'in da suka rage a cikin kicin, zaku iya shigar da ragowar insulin a cikin wannan alkairin sannan sai a yi amfani da sabon alkalami don kammala aikin da ake buƙata, ko shigar da duka kashi ta amfani da sabon sirinji na alkairin.

Kayi ƙoƙarin yin allurar ta hanyar jujjuya maɓallin kashi. Mai haƙuri ba zai sami insulin ba idan ya juya maɓallin kashi. Dole ne danna maɓallin sashi a cikin madaidaicin madaidaiciya don samun kashi na insulin.

Kada ayi ƙoƙarin canza sashin insulin yayin allurar.

Lura Alkalami na syringe ba zai ƙyale mai haƙuri ya sanya sashin insulin akan adadin adadin raka'o'in da suka rage cikin alkairin sirinji ba. Idan baku tabbata cewa ana aiwatar da cikakken maganin ba, to bai kamata ku shigar da wani ba. Wajibi ne don cire allura bayan kowane allura. Ya kamata ku karanta kuma bi umarnin da ke kunshe a cikin umarnin don amfani da miyagun ƙwayoyi. Wajibi ne a duba lakabin a alƙalin sirinji kafin kowane allura, don tabbatar da cewa ƙarshen ranar magani bai ƙare ba kuma mai haƙuri yana amfani da nau'in insulin daidai, kar a cire alamar a cikin alkairin sirinji.

Launin launi na maɓallin maganin sirinji na QuickPick ™ wanda ya dace da launi na tsiri a kan alamar sirinji kuma ya dogara da nau'in insulin. A cikin wannan jagorar, an saka maɓallin kashi. Launin launi na QuickPen ™ syringe pen body yana nuna cewa an yi nufin amfani dashi tare da samfuran Humulin ®.

Adana da watsewa

Ba za a iya amfani da alkalami ba idan ya kasance a wajen firiji fiye da lokacin da aka ayyana a cikin umarnin don amfani.

Kar a ajiye alkairin sirinji tare da allura da aka haɗe da shi. Idan aka bar allura a haɗe, insulin na iya fita daga alƙalami, ko insulin na iya bushewa a cikin allura, ta haka ya rufe allura, ko kuma kumburin iska na iya tashi a cikin kicin.

Ya kamata a adana alkalamiin da ba a amfani da shi a firiji a zazzabi 2 zuwa 8 ° C. Kar a yi amfani da alkairin sirinji idan ya daskare.

Ya kamata a adana alkalami mai sihiri da aka yi amfani da shi a zazzabi a ɗakuna, a cikin wani wuri mai kariya daga zafin rana da haske, daga nesa da yara.

Fitar da allurai da aka yi amfani da su a cikin hujin huji, kwantena masu kama da (misali, kwantena don abubuwan da ake amfani da su ko abubuwan sharar gida), ko kuma yadda likitan ku majinyacinku ya ba ku shawarar.

Zubar da alkalami da aka yi amfani da shi ba tare da allura da aka haɗa da su ba da shawarar da likitan halartar yake da shi dangane da buƙatun zubar da shara na gida.

Kar a sake amfani da akwati mai cikar sharps.

Fom ɗin saki

Dakatarwa don gudanarwar subcutaneous, 100 IU / ml. 10 ml na miyagun ƙwayoyi a cikin tsinkayen gilashin tsaka tsaki. 1 fl. sanya a cikin fakitin kwali.

3 ml kowane a cikin tsakaitaccen katun gilashin. 5 katunan katako an sanya su a cikin bolaji. 1 bl. an sanya su a cikin kwali kwali ko an saka katun a cikin allon rubutu na QuickPen ™. An sanya alkalai 5 a cikin kwali.

Mai masana'anta

An haɓaka ta: Eli Lilly da Kamfanin, Amurka. Cibiyar Lilly Corporate, Indianapolis, Indiana 46285, Amurka.

Kunshin: ZAO "ORTAT", 157092, Russia, yankin Kostroma, gundumar Susaninsky, s. Arewa, microdistrict. Kharitonovo.

Maɓallin shagon katako, QuickPen ens Sirrin Magana , Lilly Faransa, Faransa ne ya samar. Zone Industrialiel, 2 ru Colonel Lilly, 67640 Fegersheim, Faransa.

Kunshin: ZAO "ORTAT", 157092, Russia, yankin Kostroma, gundumar Susaninsky, s. Arewa, microdistrict. Kharitonovo.

Lilly Pharma LLC shine keɓaɓɓen mai shigo da Humulin ® M3 a cikin Federationungiyar Rasha

Aikin magunguna

Jinin insulin na jikin dan adam. Shiri ne na matsakaici wanda yake aiki da shi.
Babban tasirin maganin shine ƙayyadadden tsarin glucose metabolism. Bugu da kari, yana da tasirin anabolic. A cikin ƙwayar tsoka da sauran kyallen takarda (ban da kwakwalwa), insulin yana haifar da jigilar jini cikin hanzari na glucose da amino acid, yana haɓakar anabolism na furotin. Insulin yana inganta canzawar glucose zuwa cikin glycogen a cikin hanta, yana hana gluconeogenesis kuma yana ƙarfafa juyar da yawan glucose mai yawa zuwa mai.

Side effects

- Sakamakon sakamako wanda ya danganta da babban sakamakon maganin: hypoglycemia.
- Mai tsananin rashin ƙarfi na iya haifar da asarar hankali da (a wasu lokuta na musamman) ga mutuwa.
- Allergic halayen: halayen rashin lafiyan gida na yiwuwa - hyperemia, kumburi ko itching a wurin allura (yawanci yakan tsaya ne a tsakanin kwanakin da yawa zuwa makonni da yawa), halayen rashin lafiyan yanayin (faruwa ba sau da yawa, amma sun fi tsanani) - haɓaka ƙarancin ciki, gajeriyar numfashi, karancin numfashi, rage karfin jini, hauhawar zuciya, karuwar gumi. Mummunan lokuta na halayen rashin lafiyan halayen na iya zama barazanar rayuwa.
- Sauran: da yiwuwar haɓakar lipodystrophy kaɗan.

Form sashi

Dakatarwa don yin allura 100 IU / ml

Mlaya daga cikin ml na dakatarwa ya ƙunshi

abu mai aiki - insulin jikin mutum (DNA - sake hadewa) 100 IU,

magabata: distilled metacresol, glycerin, phenol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide (dangane da zinc Zn ++), hydrochloric acid 10% don daidaita pH, sodium hydroxide 10% bayani don daidaita pH, ruwa don allura.

Wani farin dakatarwa, wanda, lokacin da yake tsaye, yakan bayyanar dashi cikin bayyananniyar, mara launi ko kusan madaukakiyar launi da farin fari. A sauƙaƙe za a sake tura shi cikin saurin girgiza kai.

Kayan magunguna

Pharmacokinetics

Humulin® M3 shiri ne na insulin-matsakaici. Farawar aikin miyagun ƙwayoyi shine minti 30 bayan gudanarwa, mafi girman tasirin shine tsakanin 1 da 8.5 hours, tsawon lokacin aikin shine 14-15 hours.

Bayanin aiki na yau da kullun na aiki (glucose uptake curve) bayan gudanar da subcutaneous ana nuna shi azaman layin m a cikin hoton da ke ƙasa. Kowane bambance-bambance a cikin aikin insulin ya dogara da dalilai kamar kashi, zaɓin wurin allura, ayyukan jiki na mai haƙuri, da dai sauransu.

Aikin insulin

Lokaci (awanni)

Pharmacodynamics

Humulin M3 kwayar halittar jikin mutum ce. Suspensionaramar biyu ce don yin allura (30% Humulin Х Regular da 70% Humulin NPH).

Babban aikin insulin shine tsari na metabolism metabolism.

Bugu da ƙari, yana da tasirin anabolic da anti-catabolic akan ƙirar jiki daban-daban. A cikin ƙwayar tsoka, akwai karuwa a cikin abun da ke ciki na glycogen, kitse mai narkewa, glycerol, haɓakar haɓakar furotin da karuwa a cikin yawan amino acid, amma a lokaci guda akwai raguwa a cikin glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, catabolism na furotin da kuma sakin amino acid.