Kwatanta Drotaverin da No-Shp

Drotaverinum
Drotaverine
Kwayar kemikal
IUPAC	(1- (3,4-diethoxybenzylidene) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (as hydrochloride)
Tsarin gaba ɗaya	C24H31KADA4
Taro na Molar	397,507 g / mol
Cas	985-12-6
BugaI	1712095
Bankin Drug	06751
Rarrabawa
ATX	A03AD02
Pharmacokinetics
Yanada	100 %
Plainma na Rashin Lafiya	80 zuwa 95%
Tsarin rayuwa	A hanta
Rabin rayuwa.	daga 7 zuwa 12 hours
Nishadi	Intestines da kodan
Siffofin Sashi
Allunan, ampoules
Wasu sunaye
Bioshpa, Vero-Drotaverin, Droverin, Drotaverin, Drotaverin forte, Drotaverin hydrochloride, No-shpa ®, No-shpa ® forte, NOSH-BRA ®, Spazmol ®, Spazmonet, Spazoverin, Spakovin

Drotaverinum (1- (3,4-diethoxybenzylidene) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (as hydrochloride)) - magani ne wanda ke maganin antispasmodic, myotropic, vasodilator, tasirin hypotensive.

Form sashi

Kamfanin Drotaverin ne ya kirkireshi a shekarar 1961 daga ma'aikatan kamfanin harhada magunguna na kasar Hungary Hinoin. Har zuwa wannan lokacin, wannan kamfani yana da tsararraki al'ada wajen samar da magungunan antispasmodic. Papaverine wanda Quinoin ya samar an yi amfani dashi cikin nasara a cikin aikin asibiti na shekaru da yawa. Yayin binciken kimiyya don inganta kaddarorin papaverine da inganta haɓaka masana'antu, an samo sabon abu. Wannan abu, wanda ake kira drotaverine, ya kasance sau da yawa ya fi Papaverine inganci. A cikin 1962, maganin ya mallaka a ƙarƙashin sunan kasuwanci No-Shpa. Abin lura ne cewa a cikin wannan sunan an nuna aikin maganin. A cikin Latin, yana kama da No-Spa, wanda ke nufin Babu spasm, babu spasm. Magungunan sun yi gwaje-gwaje na asibiti, kuma an kula da amincinsa a cikin shekarun da suka gabata. Saboda tasiri, rashin lahani na dangi da ƙarancin farashi, maganin nan da nan ya sami karbuwa sosai. A cikin Tarayyar Soviet, No-Shpu ya fara amfani da shi a cikin 1970. Daga baya, Hinoin ya zama wani ɓangare na kamfanin samar da magunguna na ƙasashen duniya Sanofi Syntelabo, wanda samfuransa ke yin biyayya da ƙa'idodin ƙasa. A halin yanzu, ana ci gaba da amfani da No-Shpu a cikin fiye da ƙasashe 50 na duniya, ciki har da Rasha da mafi yawan ƙasashe bayan Soviet.

Sashi form gyara |Halin babu-shp

Ana iya siyan magungunan ta hanyar allunan da kuma maganin da ake amfani da shi don yin injections (a cikin ciki da intramuscularly). Babban bangaren shine drotaverine hydrochloride. Ana amfani da magani don kawar da bayyanar cututtuka na jinƙan spastic, wanda za'a iya keɓance shi cikin ƙwaya mai laushi na kowane ɓangaren jiki.

Magungunan No-shpa yana nufin amfani dashi azaman babba kuma yana taimakawa. A farkon lamari, yana da kyau a tsara shi don jin zafi a cikin tsarin biliary da urinary.

Kwatanta Miyagun Kwayoyi

Lokacin zabar magunguna, wajibi ne a zana daidaituwa tsakanin zaɓin da yafi dacewa don yawancin kaddarorin: nau'in kayan aiki mai aiki, saitin tsofaffin abubuwa, sashi, nau'in sakin layi, tsarin aikin, alamu da contraindications, farashi, sakamako masu illa, hulɗa tare da wasu magunguna, tasirin akan karfin tuƙin abin hawa. .

Lokacin zabar tsakanin waɗannan kayan aikin, suna ba da hankali ga kaddarorin guda ɗaya, halayen magungunan. Dukansu magunguna suna ɗauke da abu guda mai aiki (drotaverine hydrochloride), suna aiki akan ƙa'idar guda ɗaya. Sashi na wannan bangaren shima baya canzawa - 40 ml a kowane fanni. Don haka, tsarin allurai ya zama iri ɗaya.

An tsara magunguna biyu bisa ga nau'in cutar. Sashin aiki mai aiki a cikin abubuwanda ke haifar dasu shine ya haifar da cigaban sakamako masu illa guda daya. Saboda haka, contraindications wa yin amfani da abubuwan magani ba su bambanta ba. A shiryayye rayuwar da kwayoyi ta zo daidai, wanda saboda kasancewar a cikin abun da ke ciki na taimaka masu aka gyara.

Ana iya amfani da magungunan da ke ɗauke da drotaverine hydrochloride don kula da mata masu juna biyu. Dukkanin magunguna biyu ba su ba da gudummawa ga faruwar irin wannan sakamako masu illa wanda zai haifar da ƙin tuki. Dangane da sigogi da yawa, waɗannan magungunan suna iya canzawa.

Mene ne bambanci

Bambanci a cikin magungunan wadannan nau'ikan kalilan ne. An lura cewa ana samar dasu da yawa. Don haka, akwai ƙarancin zaɓin Drotaverin fiye da No-shp. Ana iya siyan wannan kayan aikin a blisters na allunan 10 a cikin adadin 1 zuwa 5 inji mai kwakwalwa. a cikin fakiti 1. Akwai bambance-bambancen magunguna a cikin hanyar kwalban da ke ɗauke da allunan 100.

Babu-spa yana samuwa a cikin allunan 6, 10 da 20 inji mai kwakwalwa. a cikin 1 blister. A cikin kwalba, zaku iya siyan samfurin wanda ya ƙunshi kwamfutoci 64 da 100. Akwai zaɓuɓɓuka masu yawa, waɗanda ke haɓaka zaɓin gwargwadon rubutaccen likita; ba lallai ne ka sayi wadataccen magani ba idan kana buƙatar takamaiman adadin magani.

Abun da ke ciki na drotaverin ya hada da abu mai crospovidone. Wannan bangare ne na taimako. Ba shi da tasirin antispasmodic. Ana amfani dashi azaman enterosorbent. Wani banbanci shine nau'in sikandar bakin ciki wanda ya ƙunshi Allunan. Misali, ana iya siyan Drotaverin a cikin fakiti na sel wanda aka yi da kayan PVZ / aluminium. Rayuwar shiryayye na allunan a wannan yanayin shine shekaru 3. Don kwatantawa, Babu-shpa yana samuwa a cikin sigogi daban-daban: PVC / aluminium da aluminum / aluminum. Lastarshe na su za'a iya ajiyewa na tsawon shekaru 5 ba tare da haɗarin asarar kaddarorin ba.

Wanne ne mafi arha

A farashin Drotaverin ya buge analog ɗin. Kuna iya siyan irin wannan magani don 30-140 rubles. ya danganta da yawan allunan. Amma-spa yana da ɗan tsada, yana cikin rukunin ƙwayoyi na rukuni na tsakiya. Duk da wannan, an yarda da farashin wannan samfurin: 70-500 rubles. Za'a iya siye magunguna biyu ta hanyar marasa lafiya na al'adunsu daban-daban. Koyaya, Drotaverin za'a ɗauki mafi kyawun sayan.

A lokacin daukar ciki da lactation

Yayin haihuwar yaro, an yarda da amfani da magunguna biyu. Wannan shi ne saboda abun da ke ciki, abubuwan da ke aiki na abu guda. Yana da mahimmanci a mai da hankali, saboda duk wani tasiri akan tasoshin zai iya haifar da ci gaban haila, wanda yanayi ne mai haɗari yayin daukar ciki, musamman idan akwai wani hali na rage matsi.

Lokacin lactation yana nufin jerin abubuwan contraindications. Haka kuma, No-spa, kamar Drotaverin, ba za'a iya amfani dashi a irin wannan yanayin ilimin ba.

Ra'ayin likitoci

Vasiliev E. G., dan shekara 48, St. Petersburg

Sau da yawa nakan rubuta magani a ƙasar Hungary (No-shpu). Ya ƙunshi drotaverine. A aikace na babu marasa lafiyar da zasu zo tare da korafi game da wannan maganin. Babu sakamako masu illa, babu rikitarwa. Ganin kwarewata, na karkata ga wannan magani. Kuma na fahimci cewa tsarin Drotaverin kusan iri ɗaya ne, amma na fi son tabbatar da No-shpa.

Andreev E. D., shekara 36, ​​Kerch

Na yi imani cewa shirye-shiryen iri ɗaya a cikin abubuwan da ke ciki za'a iya maye gurbinsu cikin lafiya Ni ɗayan waɗannan likitocin ne waɗanda ke ba da izinin mafi ƙarancin buƙata, kuma ba iyakar magunguna ba. Drotaverin shima yafi rahusa, wannan shine babban fa'idarsa. Bugu da ƙari, ana samun wannan kayan aiki a cikin Rasha, don haka na goyi bayan mai ƙirar gida.

Abin da spasmolytics taimaka daga: alamomi don amfani

Dangane da sunan, maganin rigakafi yana da mahimmanci don sauƙaƙe spasms na santsi na tsokoki tsokoki na gabobin. Koyaya, basa tasiri kan aiki na tsarin juyayi, kar keta alfarmar kyallen takarda. Drotaverin da No-shpa ana amfani da su:

1. Gynecology. Ba makawa saboda sauƙin jin zafi bayan sashin cesarean, hauhawar mahaifa, barazanar ɓata ko lokacin haihuwa,
2. Cardiology da neurology. An cire jijiyoyin manyan jijiyoyin jini da jijiyoyin jini, saukar karfin jini yana raguwa,
3. Cutar Gastroenterology da Urology. Tsarin ƙonewa na ƙwayoyin cuta, asalin hoto ko bidiyo mai zagaya yanar gizo, saƙar abinci, guba na bile.

Wasu masana suna ba da shawarar amfani da sashi mai aiki azaman murmurewa bayan raunin, tiyata.

Analgesics baya cire abubuwan da ke haifar da lalacewar ƙwayar cuta, amma sauƙaƙa alamar, ƙara dawo da aiki. Saboda haka, babban haɗarin rikitarwa tare da gudanar da tsarin rashin tsari. Likitoci sun dage kan hakan. Smallaramar ci sau ɗaya na Drotaverinum ko No-shp ba shi da tasiri.

An maganin hana daukar ciki yana da contraindication:

• Hanta ko koda
• Mai haƙuri a ƙarƙashin shekara 6
• Pathologies na tsarin zuciya da jijiyoyin jini a cikin matsanancin aiki ko a ƙarshen matakai.

Ba a ba da shawarar maganin don shayarwa ba. Amma a cikin mawuyacin yanayi, batun batun yau da kullun, ba ya cutar da uwa da ɗa.

Sau da yawa akan Intanet akwai kwatancen kwayoyi. Bayan duk wannan, suna da tasirin irin wannan, kuma No-shpa alama ce mai tsada ta Drotaverin.

Bayanin kwayoyi

Ayyukan sashin magunguna yana da nufin kawar da spasm. Appearanceaunar bayyanar tsokoki yana ƙarƙashin abubuwan da ake amfani da su na ƙwayar sodium-potassium, ƙaurawar ma'aunin ruwa. Taimakawa rage yawan motsa jiki ba kawai gabobin jiki ba, har ma da jijiyoyin jini. Sabili da haka, ana iya amfani dashi don kawar da cututtukan migraines, rage alamun cututtukan cerebrovascular. A wannan yanayin, analgesic ba ya shafar tsarin juyayi. Saboda haka, ana iya ɗauka ta hanyar marasa lafiya tare da keta alfarmar gabobin.

Magungunan yana ba da tasiri bayan mintina 12 bayan ya shiga ciki. Ana cire shi bayan sa'o'i 12 da ƙodan tare da fitsari. A wannan lokacin, kayan yana kare tsoro daga kowane irin yanayi.

Kwatanta Farashi

Drotaverin ishara ne na cikin gida. Yana da suna na duniya, wanda ba a haɗa shi da shi, sabanin No-shpa. Sabili da haka, farashi yana sau da yawa ƙananan. Tasirin aikin analgesics iri daya ne, tasirin iri daya ne. Takamaiman farashin aikin analgesic ya dogara da cibiyar sadarwa ta kantin magani, alamun kasuwanci da ƙarin abubuwan. Ya kamata kuma a san cewa Drotaverin na samarwa ne na gida, kuma an shigo da Non-shpa. Wannan lamarin yana shafar samuwar farashi.

Abinda yafi aminci don ɗauka yayin daukar ciki da lactation

A lokacin daukar ciki da lactation, tsayayyen zaɓi na kwayoyi. Likita ne kawai, gwargwadon bincike da alamu, ya zaɓi analgesic don warkarwa. Yana da mahimmanci cewa magani bai haifar da ƙarancin ƙwayar ƙwayar cuta ba, lahani na haɓaka da haɓaka na jariri, abu mai aiki baya tarawa a cikin madara. Idan lamarin yana da haɗari ga lafiyar mahaifiyar, alal misali, bayan sashin cesarean, to likitoci sun tsara No-shpa ko Drotaverin. Yana da mahimmanci a sha analgesic bisa ga umarnin, kar a wuce tsawon lokaci ko mita na shan maganin.

Ka'idar aiki da magungunan antispasmodic

Magungunan antispasmodic sune magungunan da aka tsara don sauƙaƙe spasm na santsi na tsokoki na gabobin ciki (gastrointestinal fili, bronchi, tasoshin jini, urinary da biliary fili). Akwai abubuwa masu aiki na neurotropic da myotropic wadanda ke maganin antispasmodics:

• neurotropic - inhibit na jijiya, wanda shine sanadiyyar spasm na tsokoki mai santsi. Inhibition yana faruwa a matakin tsarin juyayi na tsakiya tare da taimakon haɗuwa tare da maganin maye.
• myotropic - yi aiki kai tsaye a kan tsokoki masu santsi.

Drotaverin da No-shpa sune magungunan antispasmodic antyopasmodic na myotropic tare da kaddarorin kayan maye da na vasodilating.

Abubuwan da ke aiki a cikin magungunan duka sune Drotaverine (drotaverine). Yana rage yawan amfani da ion alli mai aiki (Ca2 +) cikin sel mai santsi ta hanyar hana phosphodiesterase da cAMP tarin. Da sauri kuma gaba daya yana cikin narkewa. Lokacin da aka gudanar da shi, bioavailability na drotaverine ya kusan 100%, rabin lokacin rabinsa shine minti 12. Kodan ya fice.

Alamu don amfani da allunan

Don dalilai na warkewa, ana amfani da waɗannan magungunan don spasms na santsi mai santsi waɗanda ke da alaƙa da cututtuka:

• biliary fili (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis),
• urinary fili (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, tenesmus na mafitsara).

A matsayin taimako na taimako:

• tare da spasms na m tsoka Kwayoyin na gastrointestinal fili (tare da peptic miki na ciki da kuma duodenum, gastritis, cardio ko pyloric spasm, enteritis, colitis, spastic colitis tare da maƙarƙashiya da ciwon hanji mai saurin motsa jiki, wanda ke tare da ƙonewa),
• tare da hauhawar jini
• tare da maganin huhu,
• tare da ciwon kai wanda damuwa,
• tare da cututtukan cututtukan mahaifa (dysmenorrhea).

Haihuwa da lactation

Gudanarwa ta baka na wadannan kwayoyi ba zai shafi ciki ba, ci gaban tayin, lokacin haihuwa ko lokacin haihuwa. Amma an ba da shawarar ku sanya waɗannan magunguna ga mata masu juna biyu tare da taka tsantsan. Yayin lactation da lactation, ba a ba da magunguna tare da drotaverine, tun da babu bayanai game da amincin irin wannan amfani.

Side effects

Lokacin ɗaukar maganin antispasmodics dangane da drotaverine, raunin tsarin rigakafi ba wuya ya bayyana kamar yadda ba a lura da halayen rashin lafiyan ba, waɗannan sune:

• angioedema,
• cututtukan mahaifa
• kurji
• itching
• hyperemia na fata,
• zazzabi
• jin sanyi
• zazzabi
• rauni.

Daga gefen CCC za'a iya lura:

• zuciya palpitations,
• jijiyoyin jini.

Cutar CNS ta bayyana kamar:

• ciwon kai
• tsananin farin ciki
• rashin bacci

Kwayoyi na iya haifar da irin wannan dysfunctions na ciki:

Contraindications

Magungunan hana amfani da wadannan kwayoyi sune:

• hypersensitivity to drotaverine ko kowane bangare na waɗannan kwayoyi,
• mai tsanani hepatic, na koda, ko gazawar zuciya (low cardiac output syndrome).

Dukansu magungunan suna rage karfin jini, saboda haka ana amfani dasu da taka tsantsan idan akwai damuwa a cikin jijiya.

Ba za a iya amfani da no-shpu da drotaverin don kula da marasa lafiya da ke fama da cututtukan cututtukan da ba a taɓa samu ba, kamar:

• shiga cikin galati
• Rashin karancin lactase,
• glucose-galactose malabsorption syndrome.

Yin hulɗa tare da wasu kwayoyi

Tare da taka tsantsan, ana amfani da waɗannan magungunan a lokaci ɗaya tare da Levodopa, saboda tasirin antiparkinsonian wannan magani yana raguwa, tsaurin kai da karuwa.

Wadannan magunguna suna ƙaruwa:

• antispasmodic mataki na wasu abubuwan antispasmodic,
• hypotension lalacewa ta hanyar maganin tricyclic antidepressants.

Drotaverine yana rage aikin spasmogenic na morphine.

Effectarfafa tasirin antispasmodic na drotaverine yana faruwa lokacin da aka haɗu da phenobarbital.

Amfani da barasa

Yayin shan waɗannan kwayoyi tare da barasa, waɗannan sakamako masu illa na iya faruwa:

• tsananin farin ciki
• rashin bacci
• raguwa a cikin karfin jini,
• urination akai-akai
• tashin zuciya ko amai
• zuciya,
• yawan zuciya
• asarar sarrafa jiki.

Ranar karewa

Analogues na waɗannan magunguna don abubuwan da ke aiki (drotaverine) sune:

• Dolce (maganin injection in ampoules of 2 ml, 20 mg / ml), Plethiko Pharmaceuticals Ltd, India,
• Dolce-40 (Allunan, 40 MG), Plethiko Pharmaceuticals Ltd., India,
• Drospa Forte (allunan, 80 MG), Nabros Pharm Pvt. Ltd, India
• Nispasm forte (Allunan, 80 MG) Mibe GmbH Artsnaymittel, Jamus,
• Babu-x-sha (bayani a cikin ampoules na 2 ml, 20 mg / ml, allunan 40 MG ko sifofin magina na 40 MG) da No-x-sha forte (Allunan, 80 MG), Lekhim, ChAO, Kharkov , Ukraine,
• Nohshaverin “Oz” (bayani a cikin ampoules of 2 ml, 20 mg / ml), Gwanin gwani "GNTsLS", LLC / Lafiya, FC, LLC, Ukraine,
• Ple-Spa (Allunan p / o Allunan, 40 MG ko maganin injection a cikin ampoules na 2 ml, 20 mg / ml), Plethiko Pharmaceuticals Ltd, India,
• Spazoverin (Allunan, 40 MG), Shreya Life Science Pvt. Ltd, Indiya.

Farashin magani

Nikolaeva R.V., mai ilimin tauhidi: “Ba na ba da shawarar sayan Non-shpu mai tsada don maganin na dogon lokaci, tunda Drotaverin yana da tasiri iri ɗaya. Idan an sha miyagun ƙwayoyi a cikin allunan 1-2 daga kowane harka, to babu bambanci a cikin waɗannan magunguna. "

Osadchy V. A., likitan dabbobi: “A lokacin daukar ciki, ana iya ba da waɗannan magunguna don rage jin zafi ko kuma akwai haɗarin fashewa don rage saurin ƙwayar mahaifa. Amma irin wannan liyafar ya kamata ya kasance a ƙarƙashin kulawar likita kuma kawai a cikin waɗannan lokuta inda ya zama dole don rage haɗarin haihuwar. "

Natalia, mai shekara 35, Kaluga: “A koyaushe ni bani da wurin dima jiki a cikin majami'ar magunguna, saboda wannan magani shine mafi kyawun magani don jin zafi da bushewa yayin haila. Na karɓi No-shpa kawai a cikin allunan. ”

Victor, dan shekara 43, Ryazan: “Magungunan ƙwayoyin cuta a cikin allunan ba su taimaka wa spasm a cikin bututun bile ba. Sai kawai injections rage zafi. Non-spa aiki sosai da sauri fiye da Drotaverin. "

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Wannan rukunin yanar gizon yana amfani da Akismet don yaƙar spam. Gano yadda ake sarrafa bayanan ra'ayin ku.

Ka'idar aiki da magungunan antispasmodic

Spasm - ƙanƙancewa mai kaifi na tsokoki. Cramps suna faruwa ta hanyoyi daban-daban, gwargwadon abin da ƙungiyoyin tsoka suka shiga. Mafi yawan lokuta a wannan lokacin akwai ciwo, wanda zai iya zama mai rauni sosai.

Rage wadannan abubuwan firikwensin na iya maganin antispasmodics kawai, wanda ke taimakawa shakatawa na tsoka.

Sakamakon yana faruwa ne a cikin mintina 12, tunda abu mai aiki yana motsa jiki daga narkewa, sannan kuma ya shiga cikin ƙwayoyin tsoka mai santsi.

Umarni na musamman

Wajibi ne a dauki magungunan tare da taka tsantsan ga duk wanda ke da wata damuwa a cikin aikin jiki, musamman, mutanen da ke fama da hauhawar jijiyoyin jini da kuma cututtukan ƙwayoyin cuta daban-daban (rashin daidaituwa na galactose, rashi lactase, gllu-galactose malabsorption syndrome).