Torvacard - umarnin don amfani, tsari na saki, alamu, sakamako masu illa, analogues da farashi

Kayan aiki mai tasiri a cikin yaki da atherosclerosis shine Torvacard. Yana rage adadin kuzari zuwa 30- 46%, rage yawan lipoprotein zuwa kashi 40-60%, kuma yana rage triglycerides. Sau da yawa ana wajabta shi don hana infarction na zuciya daga zuciya, hawan jini, cututtukan jijiyoyin zuciya, cututtukan zuciya da sauran cututtukan zuciya. Magungunan yana da tasiri musamman ga masu ciwon sukari.

Mene ne Torvacard

Wanda ya kirkiro Torvacard shine kamfanin kamfanin Czech na Zentiva. Kayan aiki yana nufin magungunan rage ƙwayar lipid, wanda aka ƙaddamar da aikinsa da ƙarancin lipoproteins mai yawa (LDL), wanda ke ɗaukar cholesterol a cikin jiki duka. A karshen wannan, Torvacard yana rage adadin kuzarin a jiki (ana tsammanin raguwar nau'ikan “mummuna” shine kashi 36-54), sabili da haka maganin yana cikin rukunan statins.

Cholesterol na dabbobi masu kiba ne kuma yana daukar aiki a cikin ayyuka da yawa da ke faruwa a jiki: yana bayar da tasu gudummawar wajen samar da bitamin D, samar da sinadarin bile, hormones, kaciya. Kashi tamanin cikin dari na cholesterol ana samarwa ta jiki, sauran suna zuwa tare da abinci. Abubuwan ba ya narke cikin ruwa, sabili da haka ba zai iya shiga cikin sel tare da magudanar jini ba. Don yin wannan, yana haɗaka tare da sunadarai na jigilar kayayyaki, samar da lipoproteins na yawancin ƙarancin yanayi.

Cholesterol ya kai gaɓoɓin dama a matsayin wani ɓangare na LDL, wanda, kodayake yana taka muhimmiyar rawa, ana kiran shi "mummunan cholesterol" saboda yana ɗaukar nauyi a jikin bangon jijiyoyin jini. Babban lipoproteins mai yawa, HDL, wanda aka sani da suna cholesterol mai kyau, suna da alhakin cire cholesterol daga jiki da kuma tsabtace ganuwar jijiyoyin jiki. Babban matakin HDL halayyar lafiyar jiki ne.

Idan maida hankali na LDL a cikin jini ya yi yawa, "cholesterol mai kyau" ya daina jure aikinsu. Sakamakon haka, ana ajiye filayen cholesterol a jikin bango na jijiyoyin jiki, wanda hakan ke haifar da toshewar kwararawar jini sakamakon toshewar sassan jikin jijiyoyin. Adadin kuɗi sau da yawa suna lalata ganuwar veins da arteries, wanda ke haifar da bayyanar ƙyallen jini, wanda ke haifar lokacin da platelet da sauran ƙwayoyin suka fara warkar da rauni.

A cikin lokaci, ƙwayoyin cholesterol suna taurare kuma suna maye gurbin ƙwayar jijiyoyin jiki masu lafiya, wanda shine dalilin da ya sa jijiyoyin jini, jijiyoyi, ƙwayoyin ruɓi suna ɓatar da ƙwaƙwalwar su. A karkashin karfin zubar jini, yawanci suna fashewa, suna haifar da babban jini ko karami. Idan zubar da jini ya gudana a yankin zuciya ko kwakwalwa, bugun zuciya zai faru. Ko da tare da taimakon lokaci, mutuwa na iya faruwa.

Don rage ƙirar cholesterol, Torvacard yana hana ayyukan enzyme HMG-CoA reductase, wanda ke da hannu a cikin samar da barasa mai mai. Wannan yana haifar da raguwa a cikin haɗin sa, kuma tare da shi zuwa rage adadin lipoproteins mai yawa. Tare tare da LDL, triglycerides kuma ana rage su - wani nau'in mai wanda yake ba jiki jiki da ƙarfi kuma yana cikin haɓakar lipoproteins. Plusarin ƙari shine adadin "kyakkyawan cholesterol" a ƙarƙashin ikon Torvacard yana ƙaruwa.

Umarnin amfani da Torvacard

A lokacin jiyya, mara lafiya ya kamata ya bi abincin da aka shirya don rage matakan kiba. Kuna iya amfani da miyagun ƙwayoyi duka tare da abinci da kan komai a ciki. Shan Torvacard yayin cin abinci yana rage jinkirin sha, amma tasirin maganin wannan ba ya raguwa. Kafin jiyya, ya zama dole a yi bincike kan matakin lipids a cikin jini, a yi wasu gwaje-gwajen da suka wajaba.

Matsakaicin ƙwayar cuta a cikin plasma ana lura da sa'a daya ko biyu bayan amfani dashi. Kashi 98% na abu mai aiki bayan shafewa cikin jini ya rataye ga sunadarai kuma ya ci gaba da aikin. Yawancin Torvacard suna barin jiki a matsayin wani ɓangaren bile bayan hanta da hanta. Tare da fitsari, ba fiye da kashi biyu ke fitowa ba. Cire rabin rayuwar shine 14 hours.

Torvacard ya sami damar murƙushe ayyukan enzyme HMG-CoA reductase saboda atorvastatin. An fito da miyagun ƙwayoyi a cikin allunan, a cikin kowane - 10, 20 ko 40 MG na wannan abun mai aiki. Packaya daga cikin fakitin ya ƙunshi allunan 30 ko 90. Baya ga abu mai aiki, abun da ke tattare da maganin ya hada da:

microcrystalline cellulose - yana daidaita tsarin narkewa, yana rage haɗuwar cholesterol da glucose, yana ɗaukar gubobi,
magnesium oxide - yana rage acidity, yana karfafa karfin kashi, yana inganta aikin zuciya, tsokoki, sel jijiyoyi,
silicon dioxide - wani enterosorbent wanda ya haɗu da gubobi, ƙwayoyin cuta, ƙwayoyin cuta da sauran samfuran abubuwa na rayuwa,
croscarmellose sodium - yana taimaka wa kwamfutar hannu ta narke cikin sauri bayan shigowa,
magnesium stearate - yana haɓaka samuwar taro a haɗe tsakanin allunan,
hydroxypropyl cellulose - lokacin farin ciki,
lactose monohydrate mai tacewa ne.

Tsarin lipids na jini (hyperlipidemia) alama ce ta alƙawarin Torvacard. Takeauki magungunan a layi ɗaya tare da abincin da ke rage ƙwayar lipoproteins mai ƙarancin ƙarfi da triglycerides, yana ƙaruwa da yawa "cholesterol mai kyau." Hakanan an tsara Torvacard a cikin halaye masu zuwa:

babban taro na triglycerides a cikin jini (hypertriglyceridemia),
dysbetalipoproteinemia,
hade da hauhawar jini da hypercholesterolemia (cholesterol),
heterozygous (na farko) da homozygous hereditary hypercholesterolemia, lokacin da abincin ba shi da tasiri,
cututtuka na tsarin zuciya da jijiyoyin jini a gaban dyslipidemia (keta haddin lipids na jini) don rigakafin bugun jini da yaduwar ƙwayar cuta.

Tare da cututtukan cututtukan zuciya da aka ambata, allunan Torvacard an wajabta su don hana bugun jini da bugun zuciya, da sauƙaƙe hanyoyin dawo da jijiyoyin jiki (farfadowa), da rage yiwuwar asibiti a gaban tashin zuciya. Adana magani lokacin da babu alamun cutar cututtukan zuciya (CHD), amma akwai abubuwan da ake bukata na bayyanuwa:

hawan jini
shan taba
ƙananan matakan ingantaccen cholesterol
sama da shekaru 55 da haihuwa
dabi'ar gado.

Don hana bugun jini, an wajabta Torvacard ga masu ciwon sukari na 2 wadanda basu da alamun cutar cututtukan zuciya, amma suna da hauhawar jini, fatar jiki (lalacewar retina), furotin a cikin fitsari (albuminuria), yana nuna matsalolin koda. Adana magani idan mai ciwon sukari yayi murmushi. Ya kamata a lura cewa atorvastatin na iya haifar da ciwon sukari a cikin mutanen da ke wannan cutar, kuma a cikin masu ciwon sukari yana kara matakan glucose. A saboda wannan dalili, kuna buƙatar ɗaukar Torvard na miyagun ƙwayoyi, tare da tsayar da bin shawarwarin likita.

Maganin yana farawa ne da kashi 10 MG kowace rana, wanda sannu a hankali ya hau zuwa 20 MG. Ba za ku iya ɗaukar fiye da 80 MG na magani a kowace rana. An zabi sashi ne ta hanyar likita, la'akari da nazarin, yanayin halayen mutum na haƙuri. Ga marasa lafiya da hyzycholesterolemia na homozygous, kashi ɗaya daidai 80 MG ne. Tsawon likitan ne ya ƙayyade yawan lokacin aikin. Ana iya samun sakamako mai yuwuwar bayan makonni biyu bayan kashi na farko. Wata daya bayan fara magani, ya kamata a dauki gwaje-gwaje don maganin lipids na jini kuma ya kamata a daidaita tsarin kulawa.

Contraindications

Ana sarrafa Torvacard a cikin hanta kafin barin jikin, don haka maganin yana contraindicated idan akwai mummunan raunuka na wannan sashin. Ba za ku iya ɗaukar miyagun ƙwayoyi tare da:

matsakaitan matakan transaminases - enzymes da alhakin metabolism a cikin jiki, taro wanda yawanci yana ƙaruwa tare da cututtukan hanta,
rashin haƙuri na lactose, glucose, rashi lactase,
shekaru zuwa shekaru 18
mutum alerji zuwa abubuwan da ke cikin magani.

Kada a rubuta Torvacard ga matan masu haifuwa waɗanda ba sa amfani da rigakafin haihuwa: gumakan za su iya cutar da jikin ɗan da ba a haife su ba. A lokacin daukar ciki, tattarawar cholesterol da triglycerides koyaushe yana ƙaruwa, tunda waɗannan abubuwa suna da muhimmanci ga cikakkiyar tayin. Ba a gudanar da nazari kan tasirin maganin a kan jarirai ba, amma an san cewa statins suna da ikon shiga cikin madara kuma suna haifar da sakamako masu illa a cikin jariri yayin shayarwa.

An tsara Torvacard a hankali don matsaloli tare da metabolism, ma'aunin ruwa-electrolyte, da hawan jini. Alcoholism, cututtukan hanta, mellitus na ciwon sukari, amai, raunin da ya faru kwanan nan, matsanancin aikin tiyata yana kuma buƙatar kulawa da hankali lokacin amfani da miyagun ƙwayoyi, ainihin dacewa da sashi da tsarin kulawa.

Side effects

Shan Torvacard na iya haifar da sakamako masu illa. Daga cikin juyayi tsarin za a iya lura:

rashin bacci
ciwon kai
bacin rai
paresthesia - wani nau'in yanayin ji na mutumci wanda halayyar ƙonewa, damewa, gosebumps,
ataxia - take hakkin daidaituwa game da motsi na tsokoki daban-daban,
neuropathy ne mai rauni mai narkewa-ƙwanƙwasa ƙwayoyin jijiya na yanayin rashin rashin kumburi.

Akwai matsaloli tare da tsarin narkewa: jin zafi a ciki, tashin zuciya, amai, zawo ko maƙarƙashiya, canje-canje a cikin ci, dyspepsia (mawuyacin abu mai narkewa). Hepatitis, jaundice, pancreatitis na iya faruwa. Tsarin ƙwayar tsoka zai iya amsawa ga Torvacard - cramps, jin zafi a cikin tsokoki da gidajen abinci, baya, myositis (kumburi tsokoki na kasusuwa).

Daga cikin sakamako masu illa na miyagun ƙwayoyi sune ciwon kirji, tinnitus, asarar gashi, rauni, hauhawar nauyi. Wani lokacin rashin koda ya faru, a cikin maza - rashin ƙarfi. Cutar ƙyamar Torvacard ta bayyana kanta kamar yadda cutar urticaria, itching, jan fata, fatar, kumburi. Gwajin jini na iya nuna raguwa a cikin ƙididdigar platelet, karuwa a cikin ayyukan hanta enzymes hanta, creatine phosphokinase, da hawa da sauka a matakan glucose.

Gudanar da Torvacard na lokaci guda tare da wasu kwayoyi suna buƙatar tattaunawa tare da likita don guje wa sakamako masu illa. Yana da haɗari don haɗuwa da atorvastatin tare da kwayoyi waɗanda ke kara mayar da hankali: irin wannan haɗuwa na iya tayar da rhabdomyolysis (lalacewar tsokoki na kasusuwa). Idan mai haƙuri ya kamata ya ɗauki irin waɗannan kwayoyi, likita ya tsara mafi ƙarancin Torvacard ga mai haƙuri yana ƙarƙashin kulawa akai-akai.

Bayanin da abun da ke ciki

Allunan suna oval, biconvex. An rufe su da farin ko farin fim fim.

A matsayin abu mai aiki, suna dauke da sinadarin atorvastatin. Abubuwa masu zuwa ana ɗauke su azaman ƙarin kayan aikin:

magnesium oxide
MCC
madara sukari
Aerosil
makarin sodium,
E 572,
low-sa hyprolose.

Harkar da aka samar da wadannan abubuwa:

sabbinne,
proyllene glycol 6000,
foda talcum
titanium fari.

Abun ciki da sashi tsari

Magungunan Torvacard yana cikin rukunin magunguna, ƙirar jini. Dangane da bayanin a cikin umarnin, shine mai hana inzyme na HMG-CoA reductase wanda ke canza substrate zuwa mevalonic acid. Ressionarfafa GMG-CoA-raguwa ya ci gaba game da Awanni 21 zuwa 29 saboda kasancewar kwayoyin kwayoyin halitta bayan metabolism na hepatic. Babban bangaren aiki, bisa ga umarnin rajistar magunguna (RLS) shine alli na atorvastatin. Abubuwan taya sun hada da magnesium oxide, silicon dioxide, lactose monohydrate, hydroxypropyl da microcrystalline cellulose.

Babban aikin magani na torvacard a cikin umarnin shine rage kira LDL a cikin hanta, kuma a haɗe - ci gaba mai ɗorewa cikin ayyukan hulɗa tare da masu karɓar wannan juzu'in na cholesterol. Hanyar samar da wannan magani shine allunan, an rufe su akan saman, a cikin kamannin kamannin kamanninsu. Akwai shi a cikin zaɓuɓɓukan kashi uku - Torvacard 10 MG, Torvacard 20 MG, Torvacard 40 MG.

Aikin magunguna na Torvacard

Torvacard magani ne wanda ke cikin rukunin magunguna masu rage yawan lipid. Wannan yana nuna cewa yana saukar da yawan lipids a cikin jini, da farko, lowers cholesterol.

An rarraba magunguna masu rage ƙananan ƙwayoyi, biyun, zuwa cikin kungiyoyi da yawa, kuma Torvakard yana cikin rukunin da ake kira statins. Kayan zaɓi ne mai haɓaka mai hana haɓaka HMG-CoA reductase.

HMG-CoA reductase wani enzyme ne wanda ke da alhakin juyawa na 3-hydroxy-3-methylglutaryl coenzyme A zuwa mevalonic acid. Mevalonic acid wani nau'i ne na kwayar cholesterol.

Hanyar aiwatar da aiki na Torvacard shine ta hana shi, shine, yana hana wannan canjin, gasa tare da kuma toshe HMG-CoA reductase. An sani cewa cholesterol, kazalika da triglycerides, ana haɗasu cikin tsarin lipoproteins mai yawa mai yawa, wanda daga baya ya juya zuwa ƙananan ƙarancin lipoproteins, hulɗa tare da masu karɓar su na musamman.

Abubuwan da ke aiki na Torvacard - atorvastatin - suna da alhakin rage ƙwayar cholesterol da ƙarancin lipoproteins mai yawa da yawa, yana taimakawa haɓaka ƙarancin mai karɓar lipoprotein a cikin hanta, akan saman sel, wanda ke shafar haɓakar haɓakar tasirinsu da rushewarsu.

Torvacard yana rage haɓakar ƙananan lipoproteins mai yawa a cikin marasa lafiya da ke fama da wata cuta kamar hyzycholesterolemia na homozygous, wanda yake mafi yawan lokuta wahalar magance shi.

Hakanan, ƙwayar tana taimakawa wajen haɓaka yawan ƙwayoyin lipoproteins masu yawa waɗanda ke da alhakin haɓakar cholesterol "mai kyau".

Pharmacokinetics da kuma kantin magunguna

Pharmacokinetics sune canje-canje waɗanda suka faru tare da magani a cikin jikin mutum. Shashi, shine, ɗaukar, shi ne mafi girma. Hakanan, maganin yana da sauri sosai ya kai matsayin maida hankali cikin jini, bayan kimanin awa daya zuwa biyu. Haka kuma, a cikin mata, adadin kaiwa ga babban maida hankali yana sauri da kusan 20%. A cikin mutanen da ke fama da cututtukan hanta sakamakon shan giya, maida hankali kansa ya ninka har sau 16 sama da na yau da kullun, kuma adadin nasarorin ya ninka sau 11.

Yawan sha na Torvacard yana da alaƙa kai tsaye ga cin abinci, saboda yana rage jinkirin ɗaukar abinci, amma baya tasiri rage ƙarancin ƙwayar lipoprotein cholesterol. Idan ka sha maganin da yamma, kafin lokacin bacci, to maida hankali cikin jini, sabanin asuba, zai yi matukar raguwa. An kuma gano cewa mafi girman kashi na miyagun ƙwayoyi, da sauri ana shan shi.

Rashin bioavailability na Torvacard shine kashi 12% saboda hanyar sa ta cikin mucous membrane na narkewa kamar tsarin da hanta, a inda yake cikin wani ɓangaren wucin gadi.

Magungunan kusan kusan 100% an ɗaure su ga ƙwayoyin plasma. Bayan jujjuyawar sashi a cikin hanta saboda aikin isoenzymes na musamman, ana kafa metabolites masu aiki, waɗanda ke da babban tasiri na Torvacard - suna hana HMG-CoA reductase.

Bayan wasu canje-canje a cikin hanta, ƙwayar da tare da bile ya shiga cikin hanji, ta hanyar da ake cire shi gaba ɗaya daga jiki. Rabin rayuwar Torvacard - lokacin lokacin da yawan ƙwayoyi a cikin jiki ya ragu daidai 2 sau - shine 14 hours.

Ana iya ganin tasirin miyagun ƙwayoyi na kusan kwana ɗaya saboda aikin ragowar metabolites.A cikin fitsari, ana iya gano ƙananan ƙwayar magunguna.

Yana da daraja la'akari da cewa a lokacin hemodialysis ba a nuna shi ba.

Alamu don amfani da miyagun ƙwayoyi

Torvacard yana da alamomi da yawa sosai.

Ya kamata a lura cewa miyagun ƙwayoyi suna da duka jerin abubuwan da za a iya amfani da su, ana la'akari dasu lokacin da suke tsara maganin.

Umarni don amfani yana nuna duk shari'ar amfani da miyagun ƙwayoyi.

Daga cikinsu, manya manyan sune:

An tsara Torvacard don rage yawan cholesterol, kamar yadda ya danganta da ƙarancin lipoproteins mai yawa, zuwa ƙananan apolipoprotein B, shima triglycerides, kuma don ƙara yawan ƙwayar lipoprotein mai yawa ga mutanen da ke fama da cutar heterozygous ko hypercholesterolemia na farko, kazalika da nau'in lipid li II na lipid . Ana ganin sakamako ne kawai yayin cin abinci.
Hakanan, lokacin cin abinci, Torvacard ana amfani dashi don maganin familial endogenous hypertriglyceridemia na nau'in na huɗu bisa ga Frederickson, kuma don maganin dysbetalipoproteinemia na nau'in na uku, wanda abincin ba shi da tasiri.
Ana amfani da wannan magani ta hanyar masana da yawa don rage matakin jimlar cholesterol da ƙarancin lipoproteins mai yawa a cikin cuta irin su hyzycholesterolemia na homozygous, idan abincin da sauran hanyoyin magani ba su da tasiri. Mafi yawa azaman magani na biyu.

Bugu da kari, ana amfani da maganin don cututtukan zuciya da na jijiyoyin bugun gini a cikin wadancan marasa lafiya wadanda ke da abubuwan kara hadarin kamuwa da cututtukan zuciya. Wannan ya fi shekaru 50 da haihuwa, hauhawar jini, shan sigari, hauhawar jini ta hanji, ciwon suga, hanta, cututtukan jijiyoyin jiki, da kuma kasancewar cututtukan zuciya na zuciya a cikin ƙaunatattun.

Yana da tasiri musamman tare da dyslipidemia concomitant, saboda yana hana haɓakar bugun zuciya, bugun jini, har ma da mutuwa.

Rashin halayen daga amfani da miyagun ƙwayoyi

Lokacin amfani da magani a cikin haƙuri, ɗaukacin bakan na halayen marasa illa na iya faruwa.

Yiwuwar yiwuwar tashin hankalin yakamata a yi la’akari da lokacin da ake rubuta magani.

Yawancin sakamako masu illa lokacin amfani da maganin yana haifar da ƙayyadaddin dokar hana sarrafa kai lokacin shan magani. Maganin ya cancanci a rubuta shi ta likita kawai, la'akari da halayen jikin mai haƙuri.

Lokacin amfani da miyagun ƙwayoyi Torvakard, waɗannan nau'ikan halayen masu illa suna faruwa:

Tsarin tsakiya da na jijiyoyin jiki - ciwon kai, farin ciki, wahala, bacci, bacci, raunin ƙwaƙwalwar ajiya, raguwa ko nakasasshen yanayin yanki, rashin damuwa, ataxia.
Tsarin narkewa - maƙarƙashiya ko zawo, wata jin tashin zuciya, tsanya, ƙanƙanta mai yawa, jin zafi a cikin yankin, ƙarancin abinci, yana haifar da cutar anorexia, ita ma wannan hanyar ce, kumburinsa a hanta da ƙwayar cuta, jaundice saboda tururuwa na bile,
Tsarin Musculoskeletal - sau da yawa akwai jin zafi a cikin tsokoki da gidajen abinci, myopathy, kumburi da ƙwayoyin tsoka, rhabdomyolysis, jin zafi a baya, ƙanƙancewa na tsokoki na ƙafa,
Bayyanar bayyanar cututtuka - itching da kurji a kan fata, urticaria, amsawar rashin lafiyan kai tsaye (anaphylactic shock), Stevens-Johnson da syndromes na Lyell, angioedema, erythema,
Manuniya na dakin gwaje-gwaje - haɓaka ko raguwa a cikin glucose na jini, haɓaka a cikin aikin creatiphosphokinase, alanine aminotransferase da aspartate aminotransferase, haɓaka haɓakar jini mai haɓaka,
Wasu kuma - ciwon kirji, kumburi daga baya da na sama, rashin ƙarfi, alopecia mai da hankali, hauhawar nauyi, rauni gaba ɗaya, raguwar faranti, gazawar na biyu.

Abubuwan halayen mara kyau na duk magunguna na ƙungiyar statin sun kuma bambanta:

rage libido
gynecomastia - haɓakar glandar dabbobi masu shayarwa a cikin maza,
ƙwayar tsoka,
Damuwa
cutar cututtukan huhu da ke yawan samun magani,
bayyanar cutar sankarau.

Ya kamata a kula da kulawa ta musamman yayin ɗaukar Torvacard da cytostatics, fibrates, maganin rigakafi da magungunan antifungal, tun da kullun basu dace ba. Wannan kuma ya shafi glycosides na zuciya, musamman Digoxin.

Irin waɗannan analogues na Torvacard ana samar dasu kamar Lovastatin, Rosuvastatin, Vasilip, Liprimar, Akorta, Atorvastatin, Zokor.

Yin bita game da miyagun ƙwayoyi galibi tabbatacce ne, tun da statins sune ƙungiyar masu amfani da kwayar cuta da ke rage ƙwayar cuta.

Masana za su yi magana game da mutummutumai a cikin bidiyo a cikin wannan labarin.

Kungiyar magunguna

Abubuwa masu aiki suna zaɓa tare da gasa suna toshe HMG-CoA reductase, enzyme da ke tattare da ƙirƙirar steroids, gami da cholesterol. Hakanan yana ƙara yawan masu karɓar LDL a cikin hanta, wanda ya haifar da karuwar haɓakawa da lalata LDL.

Atorvastatin ya rage matakan LDL a cikin marasa lafiya tare da hyzycholesterolemia na homozygous, wanda, a matsayin mai mulkin, ba za a iya bi da shi tare da wasu magungunan hypoliplera ba.

Matsakaicin ƙwayar atorvastatin ana lura da sa'o'i 1-2 bayan cin abinci. Lokacin shan magani da maraice, maida hankali ya zama 30% ƙasa da safiya. A bioavailability na miyagun ƙwayoyi ne kawai 12%, wannan saboda gaskiyar cewa abu mai aiki yana metabolized a cikin mucous membrane na narkewa da hanta da hanta. Kusan kashi 98% na magungunan suna ɗaure zuwa garkuwar jini. An cire shi daga jiki tare da bile, rabin rayuwar tsawon awanni 14.

Na manya

Torasemide a hade tare da abinci an wajabta:

don rage haɓakar yawan ƙwayoyin cuta, ƙananan ƙarancin lipoproteins, apolipoprotein B da triglycerides, kuma don haɓaka abubuwan lipoproteins mai girma-yawa a cikin marasa lafiya tare da hyperlipidemia na farko, heterozygous familial da rashin familial hyperlipidemia, da kuma haɗuwa (hade) hypercholesterolemia II
tare da karuwa a cikin triglycerides (nau'in IV a cewar Fredrickson),
tare da dysbetalipoproteinemia (nau'in III a cewar Fredrickson),
tare da hyzycholesterolemia na homozygous don rage yawan ƙwayar cholesterol da ƙarancin lipoproteins mai yawa.

An tsara Torasemide don cututtuka na tsarin zuciya da jijiyoyin jini ga marasa lafiya waɗanda ke da haɗarin haɗarin cututtukan zuciya na jijiyoyin jini - fiye da shekaru 55, maganin nicotine, hawan jini, ciwon sukari mellitus, cututtukan jijiyoyin bugun jini, tarihin bugun jini, hagu na jini, ventricular hauhawar jini, furotin a cikin fitsari, cututtukan zuciya na zuciya a dangi. dangi, gami da sakamakon cutar dyslipidemia. A cikin waɗannan marasa lafiya, shan miyagun ƙwayoyi yana rage yiwuwar mutuwa, infarction myocardial, bugun jini, sake komawa asibiti saboda angina pectoris da buƙatar farfadowa.

Kada a rubuta Torvacard ga ƙananan yara.

Ga masu juna biyu da masu shayarwa

Torvacard yana cikin contraindicated a cikin marasa lafiya a cikin matsayi da shayarwa. Bai kamata a yi amfani da miyagun ƙwayoyi ga mata masu haifuwa ba idan ba su yi amfani da abin da ake iya kiyayewa ba. Akwai sanannun lokuta game da haihuwar yara tare da cututtukan da ke ɗauka a cikin yanayin yayin da aka ɗauki batun su yayin daukar ciki Torvacard.

Side effects

Matsalar da za a iya biyo baya na iya faruwa yayin lura tare da Torvacard:

ciwon kai, rashin ƙarfi, farin ciki, damuwa, bacci, wanda zai iya bayyana ta hanyar bacci, bacci, rashin bacci, asarar ƙwaƙwalwa ko rashin ƙarfi, ɓacin rai, polyneuropathy na farji, hawan jini, paresthesia, ataxia,
ciki, ciwon ciki, tashin zuciya, amai, gudawa, zazzabin cizon sauro, rashin jin daɗi, hepatitis, kumburi, kumburi, kumburin ciki, yawan ci, cikakken rashin ci,
tsoka da ciwon haɗin gwiwa, ciwon baya, myopathy, kumburi da kasusuwa ƙashi, rhabdomyolysis, cramps kafa,
rashin lafiyan halayen, wanda ke bayyana ta hanyar kumburi, ƙoshin fatar, da cutar urticaria, edema na Quincke, anaphylaxis, rashes, erythema multiforme exudative,
haɓaka ko raguwa da glucose jini,
haɓaka abubuwan da ke cikin gemocosylated haemoglobin, ayyukan hanta enzymes,
kirji yayi zafi
kumburi na ƙarshen,
erectile tabarbarewa
na yau da kullun asarar gashi
kunne a cikin kunnuwa
raguwa a matakan platelet a cikin jini,
sakandare na koda
nauyi
rauni da malaise.

Yin hulɗa tare da wasu kwayoyi

Tare da gudanarwa na lokaci guda na atorvastatin da cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressants da antimycotics na ƙungiyar azole, nicotinic acid da nicotinamide, magungunan da ke hana metabolism, tare da halartar 3A4 CYP450 na karuwa ko kuma haɗuwa, da kuma hadarin kamuwa da cutar sankara. Sabili da haka, lokacin da irin wannan haɗuwa ba makawa, kuna buƙatar auna haɗari da fa'idarsa. Marasa lafiya da ke karɓar irin wannan haɗin haɗin gwiwa ya kamata su kasance a ƙarƙashin kulawa ta likita kuma, idan an gano ƙwaƙwalwar ƙarancin ƙarancin ƙwayar cuta ko alamun cutar myopathy, Torvacard ya kamata a daina.

Colestipol yana saukar da maida hankali kan atorvastatin, amma tasirin rage zafin wannan haɗin yana sama da na waɗannan magungunan dabam daban.

Atorvastatin yana ƙaruwa da tasirin kwayoyi waɗanda ke rushe matakin ƙwayoyin steroid na endogenous.

Lokacin da aka tsara atorvastatin a cikin maganin yau da kullun na 80 MG guda tare da maganin hana haihuwa dangane da northindrone da ethinidestraliol, an lura da ƙaruwa cikin taro na hana ruwa cikin jini.

Lokacin ɗaukar atorvastatin a cikin maganin yau da kullun na 80 MG tare da digoxin, an lura da karuwa a cikin taro na glycoside cardiac.

Umarni na musamman

Kafin ɗaukar Torvacard, rage cholesterol ya cancanci ƙoƙari tare da rage cin abinci, ƙara yawan aiki na jiki, asarar nauyi a cikin marasa lafiya tare da kiba da kuma lura da wasu cututtukan.

A kan tushen magani, aikin hanta na iya zama mai rauni, don haka dole ne a bincika yanayinsa kafin a fara Torvacard, makonni 6 da 12 bayan fara magani, bayan wani ƙaruwa na sashi, kuma a lokaci-lokaci, alal misali, sau ɗaya a kowane watanni shida. Yayin maganin, ana iya lura da karuwa a cikin ayyukan hanta na hanta, musamman a farkon watanni 3 na jiyya, amma idan waɗannan alamomin sun shagala fiye da sau 3, dole ne ko dai rage yawan atorvastatin ko kuma dakatar da shan shi.

Hakanan, yakamata a dakatar da aikin jiyya idan akwai alamun cutar myopathy, kasancewar halayen haɗari don rashin lafiyar koda saboda rhabdomyolysis, kamar ƙarancin jini, matsanancin kamuwa da cuta, tiyata mai zurfi, rauni, rikicewar rikice-rikice, cuta na rayuwa, rikicewar endocrine.

A kan asalin ilimin, matakan glucose a cikin jiki na iya ƙaruwa, a cikin wasu marasa lafiya, bayyanar cutar mellitus mai yiwuwa, wanda ke buƙatar sadar da wakilai na hypoglycemic.

Magungunan ba ya tasiri da ikon tuki.

Yanayin ajiya

Ya kamata a adana Torvacard ta hanyar isa ga yara har tsawon shekaru 4 daga ranar da aka ƙera maganin. Ana bayar da maganin daga kantin magani bisa ga umarnin likita, don haka ba a basu izinin magani ba.

Anvistat. Wannan magani ne na Indiya wanda yake samuwa a cikin allunan. Su, ba kamar Allunan Torvacard ba, suna cikin haɗari, wanda ya dace wa marasa lafiya waɗanda ba sa iya hadiye maganin gaba ɗaya.
Atomax Kamfanin magani na India shine HETERO DRUGS Limited. Ana samuwa a cikin zagaye, allunan biconvex tare da haɗari. Rayuwar shiryayye na miyagun ƙwayoyi shine shekaru 2.
Atorvastatin. Magungunan an samar da shi daga kamfanonin Rasha da yawa. Farashinsa yayi ƙasa da na Torvacard, amma kamar yadda ƙarshen, zaka iya tabbata game da bambanci daga maganin gida. Rayuwar shiryayye na Atorvastatin na iya zama ya fi guntu fiye da na Torvacard, alal misali, shekaru 3 kenan ga wani magani wanda Biocom CJSC kera.

Kuna iya ɗaukar misalin analog maimakon Torvacard kawai bayan tuntuɓar likita.

Farashin Torvacard shine matsakaici na 680 rubles. Farashin ya fara daga 235 zuwa 1670 rubles.

Yi amfani yayin daukar ciki

Haihuwa tare da amfani da wannan statin lamari ne mai daukar hoto. Dangane da umarnin, ba a kuma sanya magani ba yayin shayarwa, saboda cewa ba a bayyana shi daidai ba ko bangaren da ke aiki, atorvastatin, ya shiga cikin madarar nono.

Dangane da umarnin, ba a sanya shi a cikin ilimin likitancin yara ba saboda rashin tabbacin tushe don aikace-aikacen a cikin wannan masana'antar.

Yin hulɗa tare da wasu kwayoyi

Hadarin bayyanar da ci gaban myopathy lokacin da ake tsara magunguna masu rage rage yawan tasirin cholesterol yana ƙaruwa tare da amfani da kwayoyi masu yawa. Musamman ma, fibrates, antimicrobials (abubuwan da aka samo asali na Azole), cyclosporine, da sauran wasu magunguna. Jagororin suna ɗauke da jerin kayan aikin, ma'amala tare da wanda ya ke da abubuwa da yawa:

Tare da layi daya saduwa da torvacard tare da phenazone ko warfarin - Babu alamun bayyanar cututtuka mai mahimmanci a cikin asibiti.
Tare da gudanarwar synchronous na kwayoyi, kamar cyclosporine fibrates (gemfibrozil da sauran kwayoyi na wannan rukunin), immunosuppressants, antimycotic jami'ai na abubuwan azole, magungunan da ke hana metabolism tare da CYP450 isoenzyme 3A4, ƙwayar plasma na Torvacard yana ƙaruwa. Kulawa na asibiti irin waɗannan marasa lafiya kuma, idan ya cancanta, ana ba da shawarar gudanar da magunguna kawai a fara allurai.
Tare da amfani da lokaci guda na Torvacard a cikin adadin 10 MG kowace rana kuma azithromycin a cikin adadin 500 MG kowace rana, Kungiyar ta AUC ta farkon su a cikin plasma ba ta canzawa ba.
Tare da amfani da layi daya na wannan statin da magungunan warkewa, wanda ya ƙunshi hydroxyxides na magnesium da aluminium, statin AUC a cikin jini ya ragu da kusan 30-35%, amma tasirin asibiti bai canza ba kuma matakin raguwa a LDL a cikin ƙwayar jini bai canza ba, duk da haka, likita iko ake bukata.
Colestipol. Hakanan ga gumakan da ake nazari a yau, Hakanan wani abu ne wanda yake rage rage kiba a cikin rukunin musayar anion. Tare da aikace-aikacen abokantaka, maida hankali a cikin plasma na Torvacard ya ragu da kusan kwata, amma ƙarshen tasirin asibiti daga farkon amfani da kwayoyi synchronously ya kasance mafi girma daga ɗayansu daban.
Na'urar hana haihuwa. Gudanarwa mai daidaituwa game da steatin da aka ɗauka a cikin babban kashi (80 milligrams) tare da waɗannan magungunan yana haifar da karuwa a bayyane a cikin matakan abubuwan haɗin hormonal na miyagun ƙwayoyi. Dangane da umarnin, AUC na estiniol estradiol yana ƙaruwa da kashi 20%, kuma norethisterone da kashi 30%.
Digoxin. Haɗuwa tare da digoxin yana haifar da gaskiyar cewa yawan ƙwayar plasma torvacard yana ƙaruwa da 20%. Marasa lafiya waɗanda ke karɓar digoxin a hade tare da statin a mafi girman kashi (80 milligrams - mafi girma, umarnin da aka tsara) dole ne a sa ido har abada.

Farashin magani

Matsakaicin farashin magani a kan shelf na kantin magani ya dogara da kashi da adadin allunan a cikin fakitin. A Rasha matsakaicin farashin Torvakard a kasar shine:

Torvacard 10 MG - kusan 240-280 rubles don allunan 30, don Allunan 90 za ku sami adadin a cikin adadin 700-740 rubles.
Torvacard 20 MG - kimanin 360-430 rubles don allunan 30 da 1050 - 1070 rubles don Allunan 90, bi da bi.
Torvacard 40 MG - kimanin 540 - 590 rubles don allunan 30 da 1350 - 1450 rubles don 90 guda.

A cikin Ukrainian Kasuwancin magunguna don Torvacard a cikin magunguna sune kamar haka:

Torvacard 10 MG - kimanin 110-150 UAH don allunan 30, don Allunan 90 zaka buƙaci bayar da adadin a cikin kewayon 310 - 370 UAH.
Torvacard 20 MG - kimanin 90 - 110 UAH na Allunan 30 da 320 - 370 UAH na Allunan 90, bi da bi.
Torvacard 40 MG - farashin ya bambanta daga 220 zuwa 250 UAH na Allunan 30.

Dokar farashi ya dogara da ƙasa da masana'anta, kan halayen kasuwar magunguna, kan ka'idar farashin yanki na gida.

Analogs Torvakard

Torvacard - magani wanda ya tabbatar da kansa sosai, yana nuna kyakkyawan sakamako a asibiti kuma yana da arha kuma - mai arha cikin farashi. Koyaya, a wasu halaye (rashin haƙuri na mutum, canji a rubutattun likitanci, canji a yanayin mai haƙuri), yana iya zama dole a zaɓi analog maimakon torvacard.

Akwai masu canji tare da abu guda mai aiki a cikin umarnin, kamar yadda tare da Torvakard - Atorvastatin. Wadannan sun hada da Atokor, Atoris, Liprimar, Torvazin, Tulip, Livostor.

Baya ga su, ƙwararrun likitoci na iya zaɓaɓɓiyar takwaran aikin gona. kungiyar kuma tana da mutum-mutumi. Wadannan sun hada da kwayoyi kamar Acorta, Rosuvastatin, Krestor, Rosucard, Rosart, Lipostat, Roxer, Simgal da sauransu.

Yin Amfani da Bita

A tsakanin likitoci, game da sake dubawar torvakard musamman suna kwance da hankali. Yana sau da yawa yana bayyana a cikin alƙawura don hypercholesterolemia na kwayoyin halitta daban-daban. A cikin shekaru, wannan magani ya tabbatar da inganci a aikace.

Zhilinov S.A. Endocrinologist, Ufa: "Na jima ina ba da haƙuri ga marasa lafiya na. A koyaushe ina ganin sakamako tabbataccen sakamako tare da mafi ƙarancin rikitarwa ko sakamako masu illa. Yana yin aiki sosai a cikin lura da yanayi tare da cholesterol mai yawa. Bugu da ƙari, a cikin rigakafin ischemia na zuciya, yana kuma taka muhimmiyar rawa. Kuma a farashinsa yana samuwa ga kusan kowane haƙuri. "

Kamar likitoci, marasa lafiya suma suna zurfafa tunani game da wannan magani. Idan aka kwatanta da sauran sanannun gumakan, farashin da kuma kasancewa na miyagun ƙwayoyi suna da kyan gani.

Vasilenko S.K., direban tasi, ɗan shekara 50, Kerch: Na taba samun cholesterol a cikin jadaddina a shekaru shida da suka gabata. Na je asibiti, Likita na cikin gida ya ba ni Torvakard. Da farko na yi tunanin cewa na kashe kuɗi a banza, amma sai na karanta umarnin miyagun ƙwayoyi, na saurari umarnin likita kuma na fahimci cewa tasirin ba nan da nan ba ne, a hankali ne. Bayan makonni biyu, ni kaina na ji canje-canje masu kyau a cikin lafiya na. Yanzu ba ni da koke-koke na fili, Ina jin kaina shekara goma. "

Chegoday E.A. Shekaru 66, Voronezh: “Tun ina karami nake da matsaloli game da cutar kwalara. Kafin ɗaukar torvacard, Na sha lypimar - kuna hukunta da umarnin, suna da kusan iri ɗaya. Amma farashin lypimar yanzu ya cije, don haka likita ya ba ni shawarar in maye gurbin shi da magani mai rahusa. Ni da kaina ban ga wani bambanci ba, babu sakamako masu illa daga wannan babban jerin a cikin umarnin, ban samu akan ko magunguna ko wannan ba. Abin takaici ne cewa lallai ne wadannan kwayoyi su bugu yanzu duk rayuwata. ”

Panchenko Vera, ɗan shekara 39, p. Antonovka: “Mahaifina ya dade yana fama da ciwon sukari mai 2, kafin a fara shi, yawan tattara glucose a cikin jini akan komai a ciki ya kai 8-9. Yana da nauyin jiki da yawa, kuma kamar yadda likitan ya fada, wannan shine dalilin da ya sa cholesterol ke kashe sikeli a cikin binciken. A cikin asibitin gundumar, an shawarce mu sosai, ban da duk maganin mu, mu sha milligram 20 na torvacard kowace dare, bisa umarnin. Ya juya ya zama dacewa - kuna buƙatar sha shi sau ɗaya kawai a rana. Kawai abin da kuke buƙata, saboda mahaifinsa kusan shekaru 70 ne kuma a cikin shekarun sa yana da wahala a gare shi ya tuna duk kwayoyin. Haka kuma, umarnin sun ce shan kwaya ba ya dogara da abinci - wannan yana da matukar amfani ga mahaifin da cutar sankara. A wata na farko, lokacin da muka fara shan wannan magani, an samu raguwa sosai a matakin cholesterol, yanzu komai yana lafiya tare da shi, yana lafiya».

Kamar yadda kuke gani, kuna yin hukunci ta hanyar bita da likitocin biyu da masu haƙuri, zaɓaɓɓen ƙwayar maganin rage ƙwaƙwalwar ƙwaƙwalwa - Torvacard - yana da ingantaccen inganci kuma ya zama ruwan dare gama gari. Hakanan sau da yawa akwai sake dubawa game da m farashin wannan statin. Ya kamata a la'akari dashi kuma a tuna cewa yana yiwuwa a rubanya torvacard kawai bayan cikakken bincike da kuma tattaunawa tare da ƙwararrun ƙwararrun, da bin cikakkun umarnin mutum.