Vozulim-N (Vozulim-N)

1 ml na miyagun ƙwayoyi ya ƙunshi:

abu mai aiki: insulin ɗan adam (injinin ƙwaƙwalwa) 100 ME (4.00 mg),

magabata: protamine sulfate 0.40 mg, zinc oxide 0.032 mg, metacresol 1.60 mg, phenol 0.65 mg, glycerol 16.32 mg, sodium phosphate disubstituted anhydrous 2.08 mg, sodium hydroxide 0.40 mg, hydrochloric acid 0, 00072 ml, ruwa don yin allura har zuwa 1 ml.

Wani farin dakatarwa, wanda, lokacin da yake tsaye, yakan bayyanar dashi cikin bayyananniyar, mara launi ko kusan madaukakiyar launi da farin fari. A sauƙaƙe za a sake tura shi cikin saurin girgiza kai.

Pharmacokinetics

Cikakken kamfani da kuma farawar insulin ya dogara da hanyar gudanarwa (subcutaneously, intramuscularly), wurin gudanarwa (ciki, cinya, gindi), kashi (girman insulin allura), maida hankali kan insulin a cikin magunguna, da dai sauransu Ana rarraba shi ba bisa ka'ida ba a tsakanin kyallen kuma ba ya ƙetare shinge na jini. kuma cikin madara mai nono. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya fitar da ita (kashi 30-80%).

Haihuwa da lactation

Babu ƙuntatawa game da lura da ciwon sukari mellitus tare da insulin a lokacin daukar ciki, tun da insulin bai ƙetare shinge na mahaifa ba. Lokacin da ake shirin daukar ciki da lokacin sa, ya zama dole a kara yin maganin cutar sankara. Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma sannu a hankali yana ƙaruwa a cikin na biyu da na uku.

Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam. Jim kaɗan bayan haihuwa, buƙatar insulin da sauri ya koma matakin da ya kasance kafin yin juna biyu.

Babu ƙuntatawa game da lura da ciwon sukari mellitus tare da insulin yayin shayarwa. Koyaya, yana iya zama mahimmanci don rage adadin insulin, sabili da haka, saka idanu a hankali na watanni da yawa ya zama dole kafin a inganta buƙatar insulin.

Sashi da gudanarwa Vozulim-N ta hanyar dakatarwa

Magungunan an yi niyya ne don gudanar da aikin jinƙai na cikin ƙasa.

Adadin da lokacin gudanar da miyagun ƙwayoyi an ƙaddara ta likita daban-daban a kowane yanayi, dangane da tattarawar glucose a cikin jini. A matsakaici, kashi na yau da kullum na miyagun ƙwayoyi ya tashi daga 0.5 zuwa 1 IU / kg nauyin jikin mutum (ya dogara da yanayin halayen mutum na haƙuri da haɗuwa da glucose jini).

Zazzabi na insulin da ke cikin yakamata ya zama zazzabi a dakin.

Yawancin lokaci ana ba da maganin a ƙarƙashin cinya. Hakanan za'a iya yin allura a cikin bangon ciki na ciki, gindi ko kafada a cikin tsinkayar tsoka mai narkewa. Wajibi ne don canja wurin allurar a cikin yankin na jikin mutum don hana haɓakar lipodystrophy.

Ana iya gudanar da Vozulim-N ko dai shi kadai ko a hade tare da insulin-gajeren aiki (Vozulim-P).

Yi amfani da katako tare da alkalami mai sirinji kawai.

Kungiyar magunguna

Ka bar bayananka

Neman Bayanan Bincike na Yanzu, ‰

Rijistar Mahimmancin magunguna da mahimmanci

Takaddun shaida na rajista Vozulim-N

• LP-000323

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Lokacin ɗauko abubuwan bayanan da aka buga a shafukan yanar gizon www.rlsnet.ru, ana buƙatar hanyar haɗi zuwa asalin bayanin.

Abubuwa da yawa masu ban sha'awa

An kiyaye duk haƙƙoƙi

Ba a ba da izinin amfani da kayan kayan kasuwanci ba.

Bayanin an yi nufin ne don ƙwararrun likitoci.

Sakamakon sakamako na magani

Sakamakon tasirin metabolism: yanayin hypoglycemic (pallor na fata, karuwar gumi, palpitations, rawar jiki, yunwa, tashin hankali, paresthesia na mucosa na baka, ciwon kai). Mai tsananin rashin ƙarfi na hypoglycemia na iya haifar da haɓakar ƙwaƙwalwar ƙwayar cuta.

Allergic halayen: fata, fitsari na Quincke, mai saukin ganewa - girgiza ƙwayar cuta.

Ayyukan gida hyperemia, kumburi da itching a wurin allura, tare da tsawan amfani - lipodystrophy a wurin allurar.

Sauran: kumburi, kurakurai na yau da kullun kurakurai (yawanci a farkon farfajiya).

Yawan damuwa

Tare da yawan yawan zubar da ruwa, ƙwanƙwasa jini na iya haɓaka.

Jiyya: mai haƙuri na iya kawar da ɗimbin ƙwayar cuta mai narkewa ta hanyar shan sukari ko abinci mai-carbohydrate. Sabili da haka, an ba da shawarar ga marasa lafiya masu ciwon sukari don ɗaukar sukari, Sweets, cookies ko ruwan 'ya'yan itace mai dadi tare da su.

A cikin mawuyacin yanayi, lokacin da mai haƙuri ya rasa hankali, 40%, ana gudanar da maganin dextrose (glucose) a cikin jijiya, intramuscularly, subcutaneously, intravenously - glucagon. Bayan ya dawo da hankali, ana ba da shawarar mai haƙuri ya ci abinci mai arzikin carbohydrate don hana sake haɓakar ƙwanƙwasa jini.

Haɗa kai

Magunguna ba tare da maganin wasu magunguna ba.

Akwai kwayoyi da yawa waɗanda ke shafar buƙatar insulin.

An inganta aikin hypoglycemic na insulin zabe beta-blockers, quinidine, quinine, chloroquine, monoamine oxidase hanawa, angiotensin tana mayar enzyme hanawa, carbonic anhydrase hanawa, octreotide, bromocriptine, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium, kwayoyi dauke da sinadarin ethanol.

Sakamakon rashin lafiyar insulin ya raunana glucagon, girma hormone, estrogens, na baka hana, steroids, iodinated thyroid hormones, thiazide diuretics, madauki diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, sulfinpyrazone, epinephrine, blockers na H1-histamine tsoka mai amsa sigina blockers "m" alli tashoshi, diazoxide , morphine, phenytoin, nicotine.

Reserpine, salicylates zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Yadda ake amfani: sashi da hanya na jiyya

Adadin da hanyar gudanar da Vosulima-R an ƙaddara daban-daban a cikin kowane yanayi dangane da abubuwan glucose a cikin jini kafin abinci da 1-2 sa'o'i bayan abinci, sannan kuma ya danganta da matsayin glucosuria da halayen cutar.

Ana gudanar da maganin s / c, cikin / m, in / in, mintuna 15-30 kafin cin abinci. Hanya mafi yawan hanyoyin gudanarwa na Vosulima-R shine s / c. Tare da ketoacidosis mai ciwon sukari, coma mai ciwon sukari, a lokacin aikin tiyata - in / in da / m.

Tare da monotherapy, yawan sarrafawa yawanci sau 3 a rana (idan ya cancanta, har zuwa 5-6 sau a rana), ana canza wurin allura kowane lokaci don guje wa ci gaban lipodystrophy (atrophy ko hauhawar mai mai subcutaneous).

Matsakaicin kullun shine 30-40 IU, a cikin yara - 8 IU, to, a cikin matsakaita na yau da kullun - 0.5-1 IU / kg ko 30-40 IU sau 1-3 a rana, idan ya cancanta - 5-6 sau a rana . A cikin adadin yau da kullun wanda ya wuce 0.6 U / kg, dole ne a gudanar da insulin a cikin nau'in 2 ko fiye da allura a cikin sassan daban-daban na jiki. Yana yiwuwa a haɗu tare da insulins masu aiki na dogon lokaci.

Ana tattara maganin Vozulima-R daga murfin ta hanyar huɗa tare da allurar sirinji mai taushi mai ƙyallen roba bayan an cire ƙwallon aluminum tare da ethanol.

Aikin magunguna

Jinin insulin na jikin dan adam. Yana da insulin na matsakaiciyar lokacin aiki. Yana daidaita metabolism, yana da tasirin anabolic. A cikin ƙwayar tsoka da sauran kyallen takarda (ban da kwakwalwa), insulin yana haɓaka jigilar ƙwayar glucose da amino acid, da haɓakar anabolism na furotin. Vosulim-P yana haɓaka juyar da glucose zuwa glycogen a cikin hanta, yana hana gluconeogenesis kuma yana ƙarfafa canzawar glucose mai yawa zuwa mai.

Side effects

Daga tsarin endocrine: hypoglycemia.

Mai tsananin rashin ƙarfi na iya haifar da asarar hankali da (a wasu lokuta na musamman) mutuwa.

Allergic halayen: halayen rashin lafiyan gida na yiwuwa - hyperemia, kumburi ko itching a wurin allura (yawanci a tsaya a tsakanin kwanakin da yawa zuwa makonni da yawa), halayen rashin lafiyan yanayin (faruwa ba sau da yawa, amma sun fi tsanani) - haɓaka ƙoshin jiki, gajeriyar numfashi, gazawar numfashi, , rage karfin jini, hauhawar zuciya, karuwar gumi. Mummunan lokuta na halayen rashin lafiyan halayen na iya zama barazanar rayuwa.

Umarni na musamman

Canjin haƙuri ga wani nau'in insulin ko zuwa shiri insulin tare da sunan kasuwanci na daban yakamata ya faru a ƙarƙashin kulawar likita.

Canje-canje a cikin aikin insulin, nau'ikansa, nau'in (porcine, insulin mutum, analogue na insulin ɗan adam) ko hanyar samarwa (DNA insulin ma'anar insulin ko insulin asalin dabbobi) na iya buƙatar daidaita sikelin.

Bukatar daidaitawa na kashi na Vosulima-R ana iya buƙatar riga a farkon gudanar da shiri na insulin ɗan adam bayan shirin insulin dabbobi ko sannu a hankali a cikin makonni da yawa ko watanni bayan canja wuri.

Bukatar insulin na iya raguwa tare da rashin isasshen aiki, ƙwayar ƙwayar cuta ko glandar thyroid, tare da ƙarancin renal ko hepatic insufficiency.

Tare da wasu cututtuka ko damuwa na damuwa, buƙatar insulin na iya ƙaruwa.

Hakanan ana iya buƙatar yin gyaran fuska yayin ƙara yawan motsa jiki ko lokacin da ake canza abinci na yau da kullun.

Nau'i na saki, marufi da abun da ke ciki

Magani don allura.

3 ml - kwandon shara (1) - fakitin bakin (1) - fakitoci na kwali.
10 ml - gilashin gilashi (1) - kwali-kwali.

Sakawa lokacin

Matsayi da hanyar gudanar da maganin an ƙayyade su daban-daban a cikin kowane yanayi dangane da abubuwan da ke cikin glucose a cikin jini kafin cin abinci da 1-2 sa'o'i bayan cin abinci, kazalika ya danganta da matsayin glucosuria da halayen hanyar cutar.

A matsayinka na doka, ana gudanar da s / c minti na 15-20 kafin cin abinci. Ana canza wuraren allurar a kowane lokaci. Idan ya cancanta, ana ba da izinin IM ko IV.

Za a iya haɗe shi da insulins masu aiki da dogon lokaci.

Side sakamako

Allergic halayen: urticaria, angioedema, zazzabi, ƙarancin numfashi, rage karfin jini.

Daga tsarin endocrine: hypoglycemia tare da bayyanannun abubuwa kamar pallor, karuwar gumi, palpitations, damuwa na bacci, tashin hankali, raunin jijiyoyin jiki, halayen-rigakafi tare da insulin na mutum, karuwa a titin na anti-insulin rigakafi tare da karuwa mai zuwa na glycemia.

Daga gefen kwayoyin hangen nesa: raunin gani na lokaci (yawanci a farkon farji).

Abubuwan da suka shafi gida: hyperemia, itching da lipodystrophy (atrophy ko hauhawar mai mai subcutaneous) a wurin allurar.

Sauran: a farkon jiyya, ana iya haila (wuce tare da ci gaba da jiyya).

Haihuwa da lactation

A lokacin daukar ciki, ya zama dole a la’akari da raguwar buƙatar insulin a cikin farkon farkon ko ƙaruwa a cikin na biyu da na uku. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Yayin shayarwa, mai haƙuri yana buƙatar saka idanu na yau da kullun don watanni da yawa (har sai an daidaita ƙarfin buƙatar insulin).

Hulɗa da ƙwayoyi

Tasirin hypoglycemic yana haɓaka ta hanyar sulfonamides (gami da magungunan maganin hypoglycemic na baki, sulfonamides), MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic anhydrase inhibitors, ACE inhibitors, ACE inhibitors, NSAIDs (gami da salicylides), anabolic (ciki har da stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, shirye-shiryen lithium, pyridoxine, quinidine, quinine, chlo, etin, chlo, chlo

Glucagon, GCS, histamine H 1 recepor blockers, maganin hana haihuwa, estrogens, thiazide da "madauki" diuretics, jinkirin tashar alli, mai juyayi, hormones thyroid, maganin tricyclic antidepressants, heparin, morphine diazropin rage tasirin hypoglycemic sakamako , marijuana, nicotine, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine duka zasu iya haɓaka da rage tasirin hypoglycemic na insulin.

Amfani guda daya na beta-blockers, clonidine, guanethidine ko reserpine na iya rufe alamun hypoglycemia.

Magunguna ba tare da maganin wasu magunguna ba.

Tsarin saki, abun da aka shirya da marufi

Dakatarwa ce ga gudanar da ayyukan karkashin kasa. 1 ml na cakuda ya ƙunshi insulin ɗan adam mai narkewa (70%) da insulin-isophan (30%) azaman abubuwa masu aiki. Hakanan, abun da ke cikin magungunan ya hada da wasu abubuwan taimako:

• ruwa don yin allura - 1 ml,
• sodium phosphate (disubstituted dihydrate) - 2.08 mg,
• protinine sulfate - 0.4 mg,
• glycerol - 16.32 mg,
• metacresol - 1.60 mg,
• zinc oxide - 0.032 mg,
• acid hydrochloric - 0,00072 ml,
• sodium hydroxide - 0.4 mg,
• phenol na bakin ciki - 0.65 mg.

Yana da wani farin bayani, wanda a lokacin ajiya aka stratified a cikin wani farin prerawa da kuma wani m allahntaka. Lokacin da aka girgiza, komawa zuwa dakatarwa

An shirya magungunan a cikin gilashin gilashi tsaka tsaki na 10 ml, wanda aka sanya a cikin kwali.

A matsakaici - 1200 rubles.

Umarnin don amfani (hanya da sashi)

"Vozulim" an yi shi ne don gabatarwa cikin kitse mai kitse. Doka da lokacin amfani da su ne ƙwararren likita mai halartar ya danganta da alamun alamomin glucose a cikin jini. Yawanci, tsarin yau da kullun ya bambanta daga 0.5 zuwa 1 IU / kg dangane da halayen mutum na mai haƙuri.

Zazzabi na dakatarwar da aka gabatar ya kamata ya zama zazzabi dakin. Matsakaicin wurin gudanarwa shine babban kashi mai cinya na cinya. Allura ta shiga yankin da muryar kewaya, an ba da bangon ciki da gindi.

MUHIMMIYA An buƙata don canza wurin allura lokaci-lokaci don hana lipodystrophy.

Marasa lafiya waɗanda ke fama da nau'in ciwon sukari na 2 na mellitus za a iya bi da su tare da Vozulim a hade tare da sauran magungunan hypoglycemic (amfani da baka), kazalika da monotherapy.

Tasiri kan iya fitar da yatsa. Wed da fur.

Dangane da babban dalilin insulin, canji a nau'ikansa ko kasancewar mahimman damuwa na jiki ko na tunani, yana yiwuwa a rage ikon hawa mota ko sarrafa abubuwa daban-daban, kazalika da shiga cikin wasu ayyukan masu haɗari waɗanda ke buƙatar haɓakar hankali da saurin halayen tunani da na motsi.