Sakamakon amfani da Amikacin 1000 MG tare da prostatitis

Magungunan an yi shi ne da fararen farin foda, daga abin da ya wajaba don shirya mafita don gudanarwar jijiya da jijiyoyin jini.

Abunda yake aiki shine amadacin sulfate, wanda a cikin kwalba 1 na iya zama 1000 mg, 500 mg ko 250 mg. Hakanan ana haɗuwa da kayan agaji: ruwa, disodium edetate, sinadarin hydrogen phosphate.

Aikin magunguna

Magungunan rigakafi ne na kwayar cuta. Magungunan suna da sakamako mai hana ƙwayoyin cuta, yana lalata nau'ikan ƙwayoyin cuta masu tsayayya da cephalosporins, suna lalata membran cytoplasmic. Idan an tsara benzylpenicillin lokaci guda tare da allura, za a lura da tasirin tasirin cutar akan wasu juzu'ai. Magungunan ba zai shafi ƙwayoyin cuta na anaerobic ba.

Formaddamar da tsari da abun da ke ciki

Ana samun maganin a cikin foda, daga wanda aka shirya maganin don allurar ciki da ciki. Abubuwa ne da ke da tsami masu launin hygroscopic microcrystalline wanda aka kawo su cikin kwalaben gilashin milim 10. Kowane vial ya ƙunshi amikacin sulfate (1000 mg). Ana sanya kwalabe 1 ko 5 a cikin kwali mai kwalliya tare da umarnin.

Pharmacokinetics

Bayan allurar rigakafi na intramuscular, ƙwayar za ta zama 100%. Penetrates cikin wasu kyallen takarda. Har zuwa 10% an ɗaure su don garkuwar jini. Ba a fallasa canje-canje a cikin jikin mutum ba. Kallonta yakeyi saidai ba'a canza shi ba tsawon awa 3. Yawan maida hankali da amikacin a cikin jini na jini ya zama iyakar awa 1,5 bayan allura. Budewar fansar - 79-100 ml / min.

Abunda yake aiki shine amadacin sulfate, wanda a cikin kwalba 1 na iya zama 1000 mg, 500 mg ko 250 mg.
Amikacin yana da sakamako mai hana ƙwayoyin cuta, yana lalata nau'ikan ƙwayoyin cuta masu tsayayya da cephalosporins, suna lalata membran cytoplasmic.
Magungunan an yi shi ne da fararen farin foda, daga abin da ya wajaba don shirya mafita don gudanarwar jijiya da jijiyoyin jini.

Pharmacodynamics

Amikacin yana da tasirin kwayan cuta. Abubuwan da ke aiki suna ma'amala da 30S ƙananan ribosomes kuma yana hana haɓakar matrix da jigilar fasalin RNA. Kwayar rigakafi ta hana samar da abubuwan gina jiki wadanda suke hadewar kwayar halittar kwayar cuta. A miyagun ƙwayoyi ne sosai tasiri a kan:

• gram-korau aerobic kwayoyin cuta (pseudomonas, Escherichia, Klebsiella, serrations, Nasihu, enterobacter, Salmonella, Shigella),
• Cututtukan ƙwayar cuta na ƙwayar cuta (staphylococci, gami da halayen dake magance penicillin da 1st cephalosporins).

Bambancin ji na ƙwarai zuwa amikacin da:

• streptococci, gami da cututtukan haemolytic,
• fecal enterococcus (dole ne a gudanar da maganin a hade tare da benzylpenicillin).

Sakamakon maganin rigakafi bai shafi ƙwayoyin anaerobic da cututtukan ƙwayoyin cuta na ciki ba. Kwayoyin rigakafin ba su halakar da enzymes waɗanda ke rage ayyukan sauran aminoglycosides.

Alamu don amfani Amikacin 1000 MG

Abubuwan da ke nuna kulawa ga magunguna sune:

• cututtukan cututtuka na tsarin na numfashi (ciwon huhu, wuce gona da iri na mashako, cututtukan mahaifa, huhun ciki),
• septicemia wanda kwayoyin cuta masu amikacin ke haddasawa,
• lalacewar kwayar cuta a cikin jakar zuciya,
• cututtuka na jijiyoyin jini (meningitis, meningoencephalitis),
• cututtuka na ciki (cholecystitis, peritonitis, pelvioperitonitis),
• cututtuka da kumburi da hanjin urinary (kumburi da kodan da mafitsara, cututtukan ƙwayar cuta na urethra),
• cututtukan raunuka na kasusuwa masu taushi (raunin raunin, na biyu da cutar ta kamu da rashin lafiyar herpetic, fashewar cututtukan cututtukan cututtukan wurare daban-daban, pyoderma, phlegmon),
• tafiyar matakai masu kumburi a cikin gabobin pelvic (prostatitis, cervicitis, endometritis),
• cututtuka na kasusuwa na kasusuwa da kyallen takaddama (cututtukan cututtukan cututtukan fata, osteomyelitis),
• Rikituwa na bayan fage wanda ya danganci farjin kwayoyin cuta.

Kayayyakin da aka Nuna

Bayanin Samfura

• Sashi: 1000 MG
• Tsarin saki: foda don shirye-shiryen bayani na d / in / a da / m na gabatarwar Maganganu mai aiki: ->
• Kamawa: fl.
• Mai masana'anta: Roba ta OJSC
• Masana'antar masana'antu: kira (Russia)
• Abubuwa masu aiki: amikacin

Foda don shirye-shiryen samar da mafita don gudanar da aikin cikin ciki da na wucin gadi - 1 vial:

Abubuwan da ke aiki: Amikacin (a cikin nau'in sulfate) 1 g.

Kwalba na 1000 ml, yanki 1 a cikin fakitin kwali.

Foda don shirye-shiryen samar da mafita don maganin ciki da sarrafa jijiyar farin ko kusan farin launi ne hygroscopic.

Bayan gudanarwa, ana samunshi cikin sauri kuma gabaɗaya. Cmax a cikin plasma na jini tare da gudanar da i / m a kashi na 7.5 mg / kg - 21 μg / ml, bayan minti 30 na iv jiko a kashi na 7.5 mg / kg - 38 μg / ml. Bayan allura ta Tmax - kimanin awa 1,5

Matsakaicin warkewa tare da iv ko gudanarwa na wucin gadi yana kiyaye tsawon sa'o'i 10-12.

Yin jingina ga furotin na plasma shine kashi 4-11%. Vd a cikin manya - 0.26 l / kg, a cikin yara - 0.2-0.4 l / kg, a cikin jarirai: a cikin ƙarancin ƙasa da mako 1 da yin nauyin ƙasa da 1500 g - zuwa 0.68 l / kg, a ƙarancin ƙasa da mako 1 da yin awo sama da 1500 g - har zuwa 0.58 l / kg, a cikin marasa lafiya da ƙwayar cystic fibrosis - 0.3-0.39 l / kg.

An rarraba shi sosai cikin ruwa mai narkewa (abun da ke ciki na ɓacin rai, nutsuwa, tasirin, tsinkaye, jijiyoyin jiki da na ruwa), ana samun su a cikin fitsari, cikin ƙarancin yanayi, cikin nono, madara mai ruwa-ruwa, ido, ƙwayar hanji, maniyyi da kashin baya. taya. Tana ratsa jiki cikin dukkanin kyallen takarda na jiki inda yake tara intracellularly, ana lura da manyan haɓakawa a cikin gabobin da ke da wadatar jini: huhu, hanta, myocardium, saɓani, kuma musamman cikin kodan, inda yake tarawa cikin abu mai ƙarfi, ƙananan taro - a cikin tsokoki, tsoput nama da ƙasusuwa .

Lokacin da aka wajabta shi a cikin magungunan warkewa na matsakaici (al'ada) don manya, amikacin baya ratsa cikin BBB, tare da kumburin maza, permeability yana ƙaruwa kaɗan. A cikin jarirai, an sami babban fifiko a cikin ƙwayar cerebrospinal fiye da na manya. Penetrates ta hanyar katangar mahaifa: an samo shi cikin jinin tayin da ruwa mai amniotic.

T1 / 2 a cikin manya - sa'o'i 2-4, a cikin jarirai - 5-8 hours, a cikin manyan yara - 2.5-4 hours. T1 / 2 na ƙarshe - fiye da sa'o'i 100 (sakewa daga tashoshin intracellular).

Kodan ya raba ta da dunƙulewar merwaƙwalwa (65-94%), galibi ba canzawa. Budewar fansar - 79-100 ml / min.

Pharmacokinetics a cikin lokuta na musamman na asibiti.

T1 / 2 a cikin tsofaffi wanda ke da rauni na aikin ƙirar ya bambanta dangane da ƙarancin nakasa - har zuwa 100 hours, a cikin marasa lafiya da cystic fibrosis - 1-2 hours, a cikin marasa lafiya tare da ƙonewa da hauhawar jini, T1 / 2 na iya zama ƙasa da matsakaici saboda karuwar karuwar hankali .

An keɓance shi a lokacin hemodialysis (50% cikin sa'o'i 4-6), ƙwanƙwalwar hanji ba ya da tasiri (25% a cikin awanni 48-72).

Semi-roba-kwayar kwayoyi masu kashe kwayoyin cuta daga rukuni na aminoglycosides, suna kashe kwayoyin cuta. Ta hanyar ɗaure zuwa sashin 30S na ribosomes, yana hana ƙirƙirar hadadden abubuwan hawa da manzon RNA, yana toshe haɓakar furotin, sannan kuma yana lalata ƙwayoyin cytoplasmic na ƙwayoyin cuta.

Yayi aiki sosai a kan microorganisms na aerobic gram-Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Wasu gram-tabbatacce microorganisms: Staphylococcus (gami da tsayayya da maganin penicillin, wasu cephalosporins). Matsakaici na aiki da ƙarfi akan Streptococcus spp.

Tare da gudanar da sabis na lokaci daya tare da benzylpenicillin, yana nuna tasirin tasirin cutar kan layin Enterococcus faecalis. Anaerobic microorganisms suna tsayayya da miyagun ƙwayoyi. Amikacin ba ya rasa aiki a ƙarƙashin aikin enzymes wanda ke hana sauran aminoglycosides, kuma yana iya kasancewa yaci gaba da ɗaukar cututtukan Pseudomonas aeruginosa waɗanda ke tsayayya da tobramycin, gentamicin da netilmicin.

Kwayar rigakafi ta rukunin aminoglycoside.

Ana gudanar dashi cikin / a cikin amikacin na minti 30-60, idan ya cancanta, ta hanyar jet.

Idan akwai matsala game da aikin fyaɗewa na yara, ragin kashi ko karuwa a tsakanin jituwa tsakanin gwamnatocin ya zama tilas. Game da batun karuwa tsakanin tazara (idan ba a san darajar QC ba, kuma yanayin mai haƙuri ya tabbata), an kafa tazara tsakanin tsarin kulawa ta hanyar da ke biye:

Don gudanarwa na iv (drip), an riga an tsabtace maganin tare da 200 ml na 5% dextrose (glucose) bayani ko 0.9% sodium chloride bayani. Yawan maida hankali da amikacin a cikin mafita ga iv bai kamata ya wuce 5 MG / ml ba.

Tazara (h) = maida hankali ne a game da taro × 9.

Idan maida hankali kan ƙwayoyin serin creatinine shine 2 mg / dl, to dole ne a gudanar da shawarar guda ɗaya (7.5 mg / kg) a kowane sa'o'i 18. Tare da karuwa a tsakanin tazara, ba a canza sashi ɗaya.

A yayin da aka sami raguwa a cikin kashi ɗaya tare da tsarin allurai na kullum, kashi na farko ga marasa lafiya da gazawar koda shine 7.5 mg / kg. Ana yin lissafin abubuwan allurai masu zuwa bisa tsari mai zuwa:

Kashi na gaba (mg), wanda aka gudanar a kowane sa'o'i 12 = KK (ml / min) a cikin mai haƙuri dose kashi na farko (mg) / KK al'ada ne (ml / min).

• Kwayar cuta ta hanji (hanji, amai, huhun ciki, huhun huhu),
• sepsis
• maganin cutar kansa,
• Cutar ta CNS (gami da cututtukan fata),
• cututtuka na ciki na ciki (ciki har da peritonitis),
• cututtukan urinary fili (pyelonephritis, cystitis, urethritis),
• cututtukan cututtukan fata da fata masu taushi (gami da ƙonewar ƙonewa, kamuwa da cutar raunuka da matsanancin asali daban-daban),
• cututtukan biliary fili
• cututtuka na kasusuwa da gidajen abinci (ciki har da osteomyelitis),
• rauni kamuwa da cuta
• cututtukan cututtukan baya

• Tantance jijiya neuritis,
• mai tsanani na rashin aiki na koda tare da azotemia da uremia,
• ciki
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi,
• hypersensitivity ga sauran aminoglycosides a cikin tarihi.

Tare da taka tsantsan, ya kamata a yi amfani da miyagun ƙwayoyi don myasthenia gravis, parkinsonism, botulism (aminoglycosides na iya haifar da cin zarafin watsawar neuromuscular, wanda ke haifar da kara rauni na kasusuwa), rashin ruwa, gazawar renal, a cikin ƙwayar haihuwa, a cikin jarirai masu tsufa, a cikin tsofaffi marasa lafiya, a cikin zamani lactation.

Contraindicated a cikin ciki da yara a karkashin shekaru 6.

Daga tsarin narkewa: tashin zuciya, amai, rashin aikin hanta mai rauni (haɓaka ayyukan ƙwaƙwalwar hepatic, hyperbilirubinemia).

Daga tsarin hawan jini: anemia, leukopenia, granulocytopenia, thrombocytopenia.

Daga gefen tsarin juyayi na tsakiya da tsarin jijiyoyin jiki: ciwon kai, nutsuwa, tasirin neurotoxic (murkushe tsoka, ƙwanƙwasawa, ƙwanƙwasawa, bugun zuciya), gurguntawar jijiyoyin jijiya (kamawar numfashi).

Daga gabobin azanci: ototoxicity (rashin bacci, raunin rashin hankali da rashin damuwa na labyrinth, kururuwa mara canzawa), tasirin mai guba a cikin kayan aikin vestibular (ganowar motsi, tsananin zafin rai, tashin zuciya, tashin zuciya).

Daga tsarin urinary: nephrotoxicity - aikin nakasa na yara (oliguria, proteinuria, microhematuria).

Allergic halayen: fata fatar, itching, flushes na fata, zazzabi, Quincke ta edema.

Abubuwan da suka shafi gida: jin zafi a wurin allura, dermatitis, phlebitis da periphlebitis (tare da gudanarwa na iv).

Magunguna ba shi da jituwa tare da penicillins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, bitamin B da C, da potassium chloride.

Matsakaicin kashi na manya shine 15 mg / kg / day, amma banda 1.5 g / day na kwana 10. Tsawon lokacin jiyya tare da / a cikin gabatarwar shine kwanaki 3-7, tare da / m - 7-10 kwana.

Ga jarirai masu farawa, kashi na farko shine 10 mg / kg, sannan 7.5 mg / kg a kowane sa'o'i 18-24, ga jarirai da yara thean shekaru 6, kashi na farko shine 10 mg / kg, sannan 7.5 mg / kg kowane 12 h don kwanaki 7-10.

Don ƙonewar ƙonewa, ana iya buƙatar kashi 5,5.5 mg / kg a kowane sa'o'i 4-6 saboda gajeriyar T1 / 2 (1-1.5 hours) a cikin wannan rukuni na marasa lafiya.

Abubuwan da ke tattare da guba - asarar ji, ataxia, amai, rashin mafitsara, ƙishirwa, rashin ci, tashin zuciya, amai, ringing ko jin motsin rai a cikin kunnuwa, gazawar numfashi.

Yadda ake ɗaukar Amikacin-1000

Magungunan yana shiga cikin jiki tare da taimakon injections. Ya kamata ku nemi shawarar likitan ku don zaɓar tsarin kulawar da ya dace ko karanta umarnin don maganin.

Kafin fara amfani da shi, yakamata ayi gwajin hankali. Saboda wannan, ana gudanar da rigakafi a cikin fata.

Ga yara sama da wata 1 da manya, zaɓin sashi guda 2 yana yiwuwa: 5 MG a 1 kilogiram na nauyin mutum sau 3 a rana ko 7.5 MG a 1 kg na nauyin mutum sau 2 a rana. A hanya na lura yana kwana 10. Matsakaicin adadin kowace rana shine 15 MG.

An haramta amfani da miyagun ƙwayoyi a cikin aikin kumburi a cikin jijiya na auditory.
An haramta Amikacin a lalacewar koda.
Yakamata ka nemi likitanka domin zabar tsarin da ya dace.
Magungunan yana shiga cikin jiki tare da taimakon injections.
Kafin amfani da miyagun ƙwayoyi, ya zama dole a gudanar da gwajin ƙwaƙwalwar ƙwaƙwalwa, don wannan ana yin maganin rigakafi a ƙarƙashin fata.
Aikin magani da Amikacin ya kai kwanaki 10.

Ga jarirai, tsarin kulawa zai bambanta. Na farko, ana wajabta su 10 MG kowace rana, bayan haka an rage sashi zuwa 7.5 MG kowace rana. Bi da jarirai bai wuce kwana 10 ba.

Sakamakon bayyanar cututtukan alamomi da tallafawa ya bayyana a rana ta farko ko ta biyu.

Idan bayan kwanaki 3-5 maganin bai yi aiki kamar yadda ake buƙata ba, ya kamata ka nemi likita don zaɓar wani magani.

Gastrointestinal fili

Mutum na iya fuskantar tashin zuciya, amai, hyperbilirubinemia.

Yakamata a yi taka tsantsan lokacin shan magani a cikin tsufa.
An nuna rashin lafiyar ga miyagun ƙwayoyi ta hanyar fatar fata, itching.
Ba da shawarar a fitar da motar ba idan an lura da sakamako masu illa: wannan na iya zama haɗari ga direba da sauran su.

Umarni na musamman

Wajibi ne wasu jama'a su bi ka'idodi na musamman don shan ƙwayoyi.

Ana iya ba da magani ga yara idan amfanin magani ya wuce cutar da za ta iya faruwa.
An wajabta maganin ga mata masu juna biyu ne kawai a waɗannan lokuta idan rayuwar matar ta dogara da shan maganin.
An haramta amfani da miyagun ƙwayoyi yayin lactation.

Yin hulɗa tare da wasu kwayoyi

Tare da amfani lokaci guda tare da wasu magunguna, mummunan halayen mai yiwuwa ne. An ba da shawarar yin amfani da kayan kwaskwarima, mafita don ruwan tabarau tare da taka tsantsan yayin jiyya.

Yayin amfani da miyagun ƙwayoyi, ana bada shawara don amfani da kayan kwaskwarima tare da taka tsantsan.
Tare da yawan shan magungunan ƙwayar cuta, mai haƙuri yana jin ƙishirwa.Idan wuce kima na maganin zai faru, dole ne a kira motar asibiti.

Haɗuwa yana buƙatar taka tsantsan

Tare da cyclosporine, methoxyflurane, cephalotin, vancomycin, NSAIDs, amfani da taka tsantsan, tunda yiwuwar haɓaka rikitar rikice na ƙirar yana ƙaruwa. Bugu da kari, a kula da kyau tare da madauki diuretics, cisplatin. Hadarin rikice-rikice yana ƙaruwa yayin ɗaukar tare da wakilan hemostatic.

Amfani da barasa

Haramun ne haramcin shan giya yayin aikin jiyya.

Analogs suna samuwa azaman bayani. Wakilai masu tasiri sune Ambiotik, Lorikacin, Flexelit.

Haramun ne haramcin shan giya yayin aikin jiyya.
Ingancin analog na maganin shine Loricacin.
Ba zai yiwu a sami magani ba idan likita bai wajabta shi ba.

Amikacin 1000 Reviews

Diana, mai shekara 35, Kharkov: “Likitan urologist ya ba da magani don kula da cystitis.Ta sha a lokaci guda wasu magunguna, magungunan jama'a. Ya taimaka da sauri, Na lura da taimako daga ranar farko. Kayan aiki yana da tasiri kuma ba shi da tsada. "

Dmitry, ɗan shekara 37, Murmansk: “Na bi da Amikacin da ciwon huhu. Magunguna mai sauri, mai tasiri yana taimakawa, kodayake ba shi da kyau a gudanar da allura sau biyu a rana. Farantawa da araha mai sauki. "