Shin statins yana haifar da nau'in ciwon sukari na 2?

Statins, wanda yawanci ana ba da izinin rage ƙwayar cholesterol, yana ƙaruwa da haɗarin kamuwa da nau'in 2 na kashi 30%. Sakamakon binciken da aka yi dan kwanan nan ya haifar da tattaunawa tsakanin duniyar i.

Statins sune ɗayan magungunan da aka ba da izini sosai a Amurka. A cikin 2012, kusan kashi ɗaya cikin huɗu na yawan jama'ar Amurka sama da 40 a zahiri kuma sun sha magungunan rage ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa a kai a kai, a cikin mafi yawan lokuta - statins. A yau, wannan adadi ya karu zuwa 28% (kodayake an tsara su ga mafi yawan adadin Baƙi).

Statins suna rage cholesterol jini ta hanyar rage haɓaka da hanta. Sun toshe sinadarin enzyme hydroxymethylglutaryl-coenzyme A-reductase a ciki, wanda ke cikin haɓakar cholesterol.

Bugu da kari, statins din ma suna rage kumburi da damuwa na damuwa. Ganin duk waɗannan tasirin da aka ɗauka tare, mutum zaiyi tsammanin mutum-mutumi mutum zai iya rage haɗarin kamuwa da ciwon sukari na 2.

Koyaya, shaidu daga yawan karatuttukan suna nuna akasin haka - yin tsawaita amfani da statins yana kara haɗarin ciwon sukari na 2. Farkon irin wannan binciken an buga shi a cikin 2008. ii.

Dangane da shi, an gudanar da bincike da yawa, ba da daɗewa ba, wanda ɗayan (a cikin 2009) ya ce, bisa ga tsarinsu, babu wani sakamako mara amfani na steatin akan haɗarin kamuwa da cutar sankara kuma saboda haka ƙarin nazarin ya zama dole iii, da sauransu (a 2010 ) - cewa akwai wani wuri don ƙara haɗarin kamuwa da ciwon sukari, amma cewa yana da matuƙar ƙarancin iv (irin wannan rashin daidaituwa a cikin sakamakon za a iya bayanin shi ta hanyar cewa wasu karatun suna tallafawa kamfanonin kamfanonin magani kansu (masu sharhi Mai fassara)).

Don gano ainihin yanayin, masu bincike daga Kwalejin Kimiyya ta Albert Einstein da ke New York sun yanke shawarar kusanci da batun ta wata hanya ta daban kuma suna mai da hankali ga masu kiba sosai kuma, sabili da haka, tare da haɓakar haɗarin haɓakar ciwon sukari na 2. Ofungiyar masana kimiyya sun yi amfani da bayanai na yau da kullun daga Shirin Kula da Maganin Cutar Kaya na Amurka (DPPOS). Gabaɗaya, yin amfani da statins ya haifar da karuwar 36% cikin haɗarin nau'in ciwon sukari na 2. Dalilin kawai da ke haifar da shakku a kan irin wannan ƙididdigar haɓakar haɓakar haɓaka shine cewa an ƙera gumakan ne bisa ƙididdigar mai haƙuri da likita, sabili da haka ba a rarraba mahalarta ba da gangan. An buga sakamakon a BMJ Open Ciwon Cutar Bincike da Kula da v.

Groupungiyar masana ilimin kimiyya da aka ambata sun ba da shawarar sosai ga masu haɗarin haɗari waɗanda ke wajabta mutum-mutumi don rigakafin cututtukan zuciya da ke kula da matakan glucose a koyaushe kuma suna yin rayuwa mai kyau.

A ƙarƙashin rinjayar irin wannan bayanan, a cikin 2012, Hukumar Abinci da Magunguna ta Amurka ta ba da gargadi game da yiwuwar karuwar haɗarin kamuwa da cutar sankara a cikin marasa lafiya da ke shan magungunan rage ƙwayoyin cutar cholesterol da kuma wahalar sarrafa glycemic a cikin waɗanda ke da ciwon sukari vi.

Sakamakon gaskiyar cewa statins suna yadu sosai a cikin Amurka kuma da gaske rage haɗarin mummunan tashe-tashen hankula, tattaunawa game da tsofaffin abubuwan da ke haifar da ciwon sukari bai ƙare ba tukuna.

Koyaya, kwanannan, yawan karatun da suke tallafawa wannan hango ya karu kamar na kwari:

• “Amfani da mutum-mutumi da kuma hadarin kamuwa da ciwon sukari,” Barty Chogtu da Rahul Bairy, Jaridar Duniya ta Cutar Cutar sukari, 2015 vii,
• "Statins da kuma hadarin kamuwa da ciwon sukari," in ji Goodarz Danaei, A. Luis Garcia Rodriguez, Cantero Oscar Fernandez, Miguel Hernan A., Kula da masu cutar sukari na 2013ungiyar Cike da Hauka ta 2013 2013.
• “Amfani da Statin da Hadarin Cutar Ciwon Cutar,” Jill R Crandell, Kiren Maser, Swapnil Rajpasak, RB Goldberg, Carol Watson, Sandra Foo, Robert Ratner, Elizabeth Barrett-Connor, Temproza ​​Marinella, BMJ Open Ciwon Bincike da Kulawa, 2017 ix,
• "Rosuvastatin don rigakafin faruwar jijiyoyin jiki a cikin maza da mata tare da furotin na C-reactive masu girma," Paul M. Ridker, Eleanor Danielson, Francisco HA Fonseca, Jacques Genest, Antonio M. Gotto, John JP Castelein, Wolfgang Core, Peter Libby, Alberto J Lorenzatti, Jean G. MacPheiden, Borg G. Nordeard, James Shepherd, New England Journal of Medicine, 2008 x,
• “Amfani da mutum-mutumi ya kara hadarin kamuwa da cutar guda 2,” Jack Woodfield, Diabetes.co.uk, 2017 xi
• “Statin-jawo ciwon sukari da sakamakonta na asibiti”, Umme Ayman, Ahmad Najmi da Rahat Ali Khan, Journal of Pharmacology and Pharmacotherapeutics, 2014 xii.

Labari na ƙarshe yana da ban sha'awa musamman. Ta ambaci bayanan cewa yiwuwar kamuwa da ciwon sukari a ƙarƙashin rinjayar statins daga 7% zuwa 32%, ya danganta da nau'in Statin, sashi da shekarun mai haƙuri. Masana kimiyya sun gano cewa statins sau da yawa suna haifar da sukari kuma suna wuce gona da iri a cikin tsofaffi. Labarin ya kuma fitar da wani tsarin da zai yiwu wanda zai tsokani masu ciwon sukari na 2:

jigon wanda a takaice yake birgima gaskiyar cewa ban da rage samar da kwayar cholesterol ta hanta, statins shima yana rage samarda insulin da insulin karfin kwayoyin, wanda a biyun, yana haifar da raguwar sautin tsoka da karfin motsa jiki.

Yawancin wasu labaran kimiyya sun tabbatar da cewa amfani da statins ne cike da rauni na tsoka da jin zafi a cikinsu sakamakon karancin cholesterol:

• "Haɗin kai tsakanin Statins da Darasi ...", Richard E. Deichmann, Carl Jay Lavi, Timothy Asher, James D. Dinicolantonio, James H. O'Keefe da Paul D. Thompson, Jaridar Ochsner, 2015 x,
• "Tasirin statins a kan kasusuwa tsoka: motsa jiki, myopathy, da kuma ƙarfin tsoka," in ji Beth Parker, Paul Thompson, Nazarin motsa jiki da Nazarin Kimiyyar Wasanni, 2012 xiv,
• "Motsa jiki yana rauni daga magungunan Statin?", Ed Fiz, Jaridar New York, 2017 xv.

Bugu da kari, kasidu a kai a kai suna bayyana cewa mutummutumai a zahiri yana kara hadarin cutar ta Parkinson da kuma ci gaba, sabanin ikirarin farko zuwa akasin xvi xvii xviii xix.

Wanene yake buƙatar statins?

Ganin yadda ake girma girma na shaidar kimiyya game da mummunan tasirin da mutum yake zaune, wasu bugu na likitanci sun tambayi likitoci da marasa lafiya su tambayi kansu shin amfanin amfani da statins ya fi nasu mummunan sakamako ko a'a.

Don haka, alal misali, idan mara lafiya yana da raunin zuciya tare da matsayin kwayar cholesterol a cikin jininsa, to tabbas yana iya buƙatar ɗaukar statins, saboda in ba haka ba yana iya mutuwa a kowane lokaci. Bugu da kari, ya kamata a haifa da tunanin cewa cutar sankari ba lallai ba zata same shi a cikin yiwuwar 100%. Idan ƙwaƙwalwar mai haƙuri ba ta yi yawa ba kuma yanayin zuciyar haƙuri ya fi ko ƙasa da gamsarwa, to watakila ya kamata ya ci abinci da motsa jiki. Koyaya, koda a wannan yanayin, ƙin ɗaukar statins ya kamata a yi la’akari da shawara tare da likita kuma an yi shi a matakai kuma a hankali. Musamman, labarin "Lafiyayyun sakamako na statin: auna fa'idodi da haɗari" na Mayo Clinic xx ma'aikatan sunyi kira ga irin wannan tsarin.

Sauran wallafe-wallafen, kamar, Aspirin vs. Statins, suna neman hanyar maye gurbin da mutummutumi tare da asfirin don marasa lafiya marasa ƙarfi. Ba kamar statins ba, asfirin baya rage cholesterol jini, amma kawai yana narke jini, yana hana barbashi cholesterol daga manne da jini. Duk da yake wasu masana sun goyi bayan wannan ra'ayi, wasu kuma sun gaskata cewa asfirin ba zai iya zama cikakkiyar musanya abubuwan gumaka ba.