Ra'ayoyi game da Crestor na miyagun ƙwayoyi
| kwayoyin hana daukar ciki | 10 MG | 28 inji mai kwakwalwa. | ≈ 1950,9 rubles |
| 10 MG | 98 inji mai kwakwalwa. | ≈ 5365.1 rub. | |
| 20 MG | 28 inji mai kwakwalwa. | ≈ 4416.5 rub. | |
| 40 MG | 28 inji mai kwakwalwa. | ≈ 5890 rub. | |
| 5 MG | 28 inji mai kwakwalwa. | ≈ 2123 rub. | |
| 5 MG | 98 inji mai kwakwalwa. | ≈ 5595 rub. |
Likitoci sun bita akan giciye
| Rating 1.3 / 5 |
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| Farashi / inganci |
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Ofaya daga cikin ƙaƙƙarfan ikon statins.
Hepatotoxicity. Wannan shine, tare da fa'idodin masu yiwuwa, mun tabbatar da cutarwa.
Tun daga shekarun 70s, ana ta kokarin aiwatar da tsarin bayanai a Amurka don samar da ingantacciyar rayuwa a cikin Amurkawa. Saboda haka, masu fansho na Amurka na yau suna ɗaukar ALT da AST kowane watanni 3 idan sun ɗauki lambobi. Abin takaici, ba mu da irin wannan umarnin.
| Rating 3.3 / 5 |
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"Crestor" shine ɗayan mutum-mutumi na farko na asali, manufar wanda yakamata a yi la’akari da shi lokacin da ake haɗarin lalacewar erectile da dyslipidemia. Ba mara kyau ba daidai ba bayanin martaba na lipid. Tare da kwarewar haɗin gwiwa, ana kyautata tasirin sakamako na farko dangane da matakin lalacewar cikin ƙasa bayan watanni 2-3 na cin abinci na yau da kullun. An zaɓi kashi ɗaya akayi daban-daban, bisa ga bayanin bayanin lipid. M takardar sa maye daga maganin cututtukan fata.
Magungunan yana da tsada, amma ga alama, Krestor ya cancanci hakan. Yiwuwar aikin hanta mai rauni.
| Rating 4.2 / 5 |
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| Farashi / inganci |
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Yana taimaka da gaske, matakin LDL yana raguwa, yana da tasiri kawai tare da amfani da hanya, don haka bai kamata ku daina shan magungunan ba bayan an sami sakamako mai warkewa mai gamsarwa.
Kyakkyawan yanayin amfani da magunguna yana sa ya zama mai sauƙi kuma mai dacewa don sarrafa cholesterol na jini.
| Rating 4.6 / 5 |
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Statin da aka fi so. Ee, masoyi, amma saboda kyakkyawan dalili. Magungunan asali, i.e. bincike sosai. Ingantaccen abu yana da kyau, rage rage kiba zai iya yiwuwa kuma a tsammaci. Kada ku manta da kula da enzymes na hanta yayin ɗaukar "Crestor" ko kowane statin. Da kyau, kuma, hakika, kar a manta cewa yakamata a ci statin, ya kasance, tare da wasu keɓaɓɓen keɓaɓɓu, na dindindin, kuma ba hanya.
| Rating 2.9 / 5 |
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Magungunan asali, rosuvastastine. Yana rage cholesterol sosai. Tabbatar da inganci don ainihin rigakafin rikicewar cututtukan zuciya.
Magani mai tsada, ba kowa bane zai iya wadatar.
Yayin shigarwar, sarrafa bayanin martaba na lipid da ALT, AST ya zama dole. Ana ɗaukar shi sau 1 a rana, da yamma.
| Rating 3.8 / 5 |
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| Farashi / inganci |
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Krestor wani kyakkyawan magani ne na duk jikin mutum. Tare da tushe shaida. Bayan watanni 1.5-2 na ci gaba da amfani, ana iya ganin sakamakon. An wajabta shi sau 1 kowace rana, an zaɓi sashi daban-daban, yayin shan maganin, kula da jigilar jini, ALT, AST.
Farashin yana da girma sosai, ba duk masu haƙuri suke ba.
An yarda da miyagun ƙwayoyi sosai, Ina ba da shawarar shi ga marasa lafiya na.
| Rating 3.3 / 5 |
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| Farashi / inganci |
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Don watanni 2, ba a nada mai yin baftisma, musamman, "don hana ci gaban filaye." Krestor ya nuna ikon rage girman plaque kawai bayan shekaru 2 na gudanarwa a kashi 40 MG kowace rana. Gabaɗaya, idan albarkatun kuɗi suka ba da damar, babu wani abin da ya fi kyau fiye da na asali. Kuma asalin rosuvastatin shine Krestor. Amma idan tambaya ita ce: ko dai ba za a kula da su da komai ba, ko kuma a ɗauki sihiri mai inganci, to, hakika, ingantacciyar ƙwayar cuta ce mafi kyau. Yana da mahimmanci a tuna cewa duk sakamakon dogon lokaci na rosuvastatin - raguwa a cikin mace-mace, abubuwan da suka faru na fyaɗewar jini da bugun jini - an nuna su ne kawai ga Crestor, saboda ba a yi nazarin sauran kwayoyin halitta ta wannan hanyar ba. Kodayake, a gaskiya, ingantaccen abu yakamata ya haifar da raguwar kwatankwacin jini a cikin jini, kuma wannan yakamata a tabbatar dashi yayin binciken da yakamata.
Iyakar abin da ya jawo shine farashin. Musamman yanzu, bayan canjin canji. Wane ne zai iya iya - ƙyale shi ya saya. Ya kamata ku sani cewa magani tare da kowane statin ba'a yi shi ba don rage cholesterol, amma don rage haɗarin infarction myocardial, bugun zuciya da mutuwa daga cututtukan zuciya. Wannan shine dalilin da ya sa yakamata a ɗauki shekaru 18 da shekaru. Don haka za a kara kiyaye ka daga matsalolin da aka ambata. Idan gicciye ya kasance ƙaunatacce a gare ku, to, zai fi kyau ku fara ƙwararraki mai kyau kai tsaye. Domin kuwa ba za a sami fa'ida bayyananniyar fa'ida daga shan ta cikin watanni-biyu-da-uku ba. Ko shakka babu cholesterol zai ragu, amma, a da babba, an dauki mutum-mutumi bawai zai rage cholesterol ba, amma don rage hadarin matsala a nau'in infarction myocardial, bugun jini, da sauransu. Kuma wannan hadarin, a matsayin mai mulkin, yana fara raguwa kawai bayan watanni da yawa daga farkon ɗaukar statins.
Idan sakamako masu illa sun faru a cikin masu haƙuri ɗaya, wannan baya nufin kwatankwacin abu ɗaya zai faru da sauran mutane. Don haka, da zarar kun saurari mutum ɗaya wanda ya karɓi gicciye (ko kuma wani abu dabam) kuma ya sami abin da ba a so, to ko kaɗan ku ɗauki wannan a asusunku. Yawancin lokaci ba zai yiwu ba a hango ko hasashen faruwar sakamako a cikin majinyaci na musamman. Kawai kawai zaka fahimci cewa yana da mahimmanci a kula da shi tare da gicciye lokacin da zaka iya siyan shi tsawon shekaru. In ba haka ba, kai tsaye siyan janareto mai inganci kuma a kula da shi (alal misali, mertenyl, ko roxer, ko tevastor).
| Rating 4.2 / 5 |
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| Farashi / inganci |
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Mafi kyawun magunguna na duk jikin mutum. Da sauri yana daidaita cholesterol zuwa matakin manufa. Ba kamar analogues ba, maganin warkewa har ma da ƙananan allurai.
Farashi, ba shakka, babba ne! Babu jayayya. Ba kowa bane zai iya wadatar shi.
Magungunan asali. Tushen tabbacin yana da ban sha'awa. Amma farashin yana tsoratar da yawancin marasa lafiyar da suke buƙatar hakan.
| Rating 3.3 / 5 |
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| Farashi / inganci |
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Yana da sauri daidaita matakan cholesterol (a cikin mako daya zai iya rage alamu zuwa al'ada).
An yi nazarin maganin sosai, tare da babban tushe, ingantaccen inganci. Yana aiki sosai cikin ƙananan allurai idan aka kwatanta da sauran kwayoyi a cikin wannan rukunin. Da kyau haƙuri. A mafi yawancin lokuta, ana ɗaukar shi ci gaba.
Nazarin haƙuri game da gicciye
Na dauki Krestor na makonni 2, tsokoki na kafafu sun fara rauni, ba zan iya yin bacci ba, Na ɗauki painkillers, mako guda ya wuce. Bayan shafewar zafin, akwai sauran muryoyin da suka rage, da kuma raunin fata lokacin da aka taba ni, zan jira wani sati har sai an cire maganin daga jikin, kuma idan zafin bai je wajen likitan kwakwalwa ba. Itauke shi, kuna buƙatar kula da abin da aka rubuta a cikin umarnin, kuma ba a san abin da yanayin hanta yake ba. Yi hankali, da alama ba a bincika maganin ba gaba daya.
Wani aboki a Kanada ya mutu saboda cutar kansa. Abu na farko da mai ilimin kanjamau ya yi bayan ya kamu da cutar shi ne ya rubuta duk magungunan da yake shan. Daga cikinsu akwai gicciye. Nan da nan ya dakatar da shi. Sai ya zama cewa a Kanada suna ƙoƙarin kada su nada shi. Akwai manyan tuhuma da cewa wannan kwayar tana haifar da cutar kansa.
Dad ya sha Krestor tsawon shekara uku. Magunguna da sauri kuma yadda yakamata a rage kwalayen. Suna son dakatar da shan maganin, amma bayan gazawa, cholesterol ya sake tashi. Don haka, dole in fara shan magungunan. Bayan wannan, baba ya fara gunaguni game da ciwon kai, rashin lafiya mara kyau, rashin barci mai yawa. Mun gano dalilan na dogon lokaci, mun wuce gwaje-gwaje daban-daban. A ƙarshe, ya zama cewa mahaifinsa yana da matsalolin hanta. Yin amfani da miyagun ƙwayoyi ya zama ba zai yiwu ba.
Yayi matukar farin ciki da maganin, yana ragewa da sauri kuma kusan ba tare da cutarwa ba. Kawai a lokacin hutu na sha Mahimman Forte N.
Likitan ya yi jinyar na tsawon watanni 2 don hana ci gaban plaque. Sayi (kamar na asali). Ban taɓa samun irin wannan rashes ba a cikin raina! Wani irin kararrakin jiki a jiki. Na sha rana 4, saboda na yi tsammani abu mai yiwuwa ne ga Magnerot a hade. Na gano hakan akan Krestor bayan komai. Yadda ake rayuwa? Barely rabu da sakamakon.
Myocardial infarction ya sa ni tunani da tunani abin da na yi da lafiyata! Ko da ya je na'urar kwaikwayo. My cholesterol na jin zafi sosai, saboda haka suka wajabta tsayayyen abinci, a kan Boiled da steamed kawai, Ina farin cikin zan iya cin 'ya'yan itace, dakatar da shan sigari, yana da wuya duk wannan. Na gwada Krestor - Na karɓa kamar yadda aka tsara, amma ban lura da wani rashin lafiyar ba. Ya zama da sauƙi a numfasawa, ƙari da gudu a kan motar motsa jiki, motsa jiki tare da mai horo. Kwayoyin suna taimakawa, amma motsa jiki shima yayi kyau. Ban sani ba, amma na fi magance magungunan kwayoyi, lokaci-lokaci, don kada a saba da ni, na dakatar da jiyya.
An wajabta giciye ga mijina bayan bugun zuciya. Binciken da aka yi ya nuna cewa yana da sinadarin cholesterol sosai a cikin jini don haka ya zama dole a hanzarta rage wadannan alamomin. Tare da yin amfani da wannan magani na yau da kullun kuma tare da tsauraran abincin, matakan cholesterol a hankali sun fara raguwa. Bayan wata daya ne binciken yayi nuni da cewa matakin cholesterol din jini ya kai matsayin da za'a karba. Likita ya ba da shawarar shan shi bayan hakan, amma magani ne mai tsada kuma ba kowa bane zai iya ɗaukar shi na dogon lokaci.
Short Short
Krestor (abu mai aiki shine rosuvastatin) magani ne na asali wanda yake na ƙarancin maye wanda ke cikin rukunin masu zaɓar masu hana haɓakar enzyme HMG-CoA reductase, wanda akafi sani da statins. Daukakar “reserve” na hauhawar jini ya dade a kan kasarmu. Hawan jini a ƙarshe ya zama ɗayan manyan abubuwan da ke haifar da nakasa da kuma mace-mace daga cutar zuciya. Ba asirin cewa ci gaban hauhawar jijiya ke gudana da hannu tare da rikice-rikice na rayuwa iri daban-daban, irin su rashin haƙuri na glucose, hyperinsulinemia (yawan ƙwayar insulin), hypeuricemia (ƙwayar uric acid a cikin jini), kiba da dyslipidemia (ƙarancin narkewar ƙwayar jijiyar jiki). A cikin batun na ƙarshe, hauhawar jini yana da alaƙa da haɓaka abubuwan da ke tattare da ƙananan ƙwayoyin tsoka na atherogenic kuma, a sakamakon haka, haɓakar atherosclerosis. Dangane da sakamakon bincike, hypercholesterolemia yana faruwa a cikin fiye da 40% na lokuta na asibiti na hawan jini. Abin sha'awa shine, a cikin marassa lafiyar maza, ƙwayar lipid ta fi atherogenic kwatancen mata. Rashin kula sosai da aka bayar don gyaran hawan jini, kazalika da kawar da abubuwan da ke tattare da haɗarin cututtukan zuciya, gami da dyslipidemia, yana haifar da ci gaba da ci gaba na atherosclerosis. Dangane da wannan, daidaituwar ƙwayar ƙwayar tsoka shine ɗayan manyan manufofin sarrafa marasa lafiya tare da hauhawar jijiya, hanyar cimma buri wanda, tare da daidaita salon rayuwa, shine amfani da statins. Sakamakon gwaje-gwaje na babban asibiti ya nuna a fili cewa statins suna rage haɗarin haɗarin cututtukan zuciya. Matsakaici na musamman tsakanin wakilan wannan rukunin magungunan yana dauke da rosuvastatin (gicciye), saboda kasancewar alfanun da aka sansu a duniya bisa "abokan aiki a shago". Krestor magani ne na roba da aka yi amfani da shi a cikin zuciya tun 2003. An yi nazari sosai game da ingancin aikin asibiti a jerin jarabawa, hade gaba ɗaya sunan GALAXY tare da rufe sama da mahalarta dubu 45.
A cikin tsarin wannan shirin, ingantacciyar tasirin magani a cikin bayanan lipid, alamun alamun kumburi mai aiki, an tabbatar da yanayin aikin atherosclerotic. Lokacin amfani da gicciye a cikin adadin allurai da aka ba da shawarar, an sami raguwar matakin "mummunan" cholesterol (LDL) ta hanyar 52-63%, wanda ya zarce daidai halayen na sauran gumakan. Bugu da ƙari, yayin jiyya tare da gicciye, matakan "mai kyau" cholesterol (HDL) yana da tabbas zai haɓaka - da matsakaicin 14%, tare da raguwa lokaci guda a cikin triglycerides. Ganin cewa matsayin yanke hukunci na halayen kumburi a cikin pathogenesis na atherosclerosis a halin yanzu ba a cikin shakka ba, ana ba da kulawa ta musamman don dalilai bayyananne ga tasirin rigakafin giciye. An gudanar da wani binciken wanda maganin ya nuna a fili tasirinsa a cikin cututtukan ƙwayar jijiyoyin ƙwayar cuta: lura da kulawa na shekaru biyu ya nuna fa'idoji ba wai kawai inganta bayanan lipid bane da daidaitattun alamomin kumburi, amma kuma a regressing atherosclerosis a cikin na jijiyoyin zuciya da carotid arteries. Don haka, an dauki batun giciye mafi kyawun magani ba kawai dangane da gyaran bayanin martaba na lipid ba, har ma da hana haɓakar atherosclerosis. Yin amfani da gicciye ya yi tasiri a cikin duka rigakafin firamare da sakandare na cututtukan zuciya. Sakamakon asibiti na maganin yana tasowa a cikin kwanaki 7, kuma bayan wata daya na mako na maganin magani ya kai ga kololuwar sa.
Ana yin gicciye a cikin allunan, wanda yakamata a hadiye shi gaba ɗaya, ba a murƙushe shi ba, a wanke shi da isasshen ruwa. Za'a iya sha magani a kowane lokaci na rana. Kafin da lokacin jiyya, dole ne mai haƙuri ya bi tsarin abinci na gargajiya da ake amfani da shi. An zaɓi kashi na gicciye daban-daban dangane da manufofin magani, sakamako mai lura da haƙuri mai haƙuri.
Crestor: umarnin don amfani
| Aikin magunguna | Krestor yana rage "LDL cholesterol" a cikin jini, a wani lokaci yana toshe abubuwan da yake samarwa a hanta. Hakanan yana rage haɗuwa da triglycerides, apolipoprotein B, ƙarancin lipoproteins mai yawa (VLDL). Yana haɓaka cholesterol mai kyau "HDL". Yana rage kumburi mara nauyi a cikin tasoshin. Inganta furotin na C-mai kunnawa da sauran alamun alamun kumburi. Sakamakon gwajin jini ya fara inganta bayan makonni 1-2, mafi girman tasirin - bayan makonni 2-4. |
| Pharmacokinetics | Ana iya ɗaukar allunan Rosuvastatin tare da abinci ko a kan komai a ciki, amfanin wannan ba ya canzawa. Rosuvastatin yana kwance daga jiki ta 90% ta hanta ta hanjin hanji, kashi 10% - daga hanta. Ba shi da ƙasa da sauran gumakan, yana ɗaukar matakan hanta waɗanda ke da hannu don tsabtace jinin abubuwa masu aiki na kwayoyi. A sakamakon wannan, yana da karancin mu'amala tsakaninsa da wasu kwayoyi fiye da siffofin ƙarni na baya. |
| Alamu don amfani | Babban kwalabe a cikin manya da matasa. Haramcin ci gaban atherosclerosis. Yin rigakafin bugun zuciya na farko da maimaitawa, bugun jini na ischemic da sauran rikitarwa na atherosclerosis. Bayan tiyata don dawo da kwararar jini a cikin tasoshin da atherosclerosis ke fama da shi. Proteinara ƙwayar C-mai kunnawa a cikin jini a gaban sauran abubuwan haɗari na zuciya, koda kuwa ƙwaƙwalwar fata al'ada ce. Shan allunan Krestor ba gurbi bane ga tsarin rayuwa mai lafiya. Yi nazarin labarin “Rage bugun zuciya da bugun jini” da aikata abin da ya faɗi. In ba haka ba, maganin zai taimaka kaɗan. |
Dubi bidiyon:
| Sashi | Fara da sashi na 5 ko 10 MG kowace rana. Bayan makonni 4, za a iya ƙara yawan kashi na Krestor, gwargwadon yadda matakan cholesterol suka canza a wannan lokacin da kuma yadda mai haƙuri yake haƙuri da magani. Koyi cholesterol na jini ga maza da mata da shekaru. Yawancin lokaci, marasa lafiya suna ɗaukar rosuvastatin 10-20 MG a rana. Ana amfani da mafi girman kashi 40 MG musamman ga mutanen da kogin sule yake da yawa sosai saboda cututtukan kwayoyin. Tsofaffi mutane, kazalika da marasa lafiya da ke da sauki koda ko na hepatic kasawa, ana wajabta su rosuvastatin a cikin daidaitattun matakan. |
| Side effects | Allunan, kamar sauran gumakan, na iya haifar da ciwon tsoka, rauni, gajiya, ƙwaƙwalwa da rikicewar tunani, rash, da tashin hankali.Binciki labarin "Sakamakon sakamako na statins" - gano yadda za a rage alamun mara kyau ko kawar da su baki ɗaya. Shirye-shiryen Rosuvastatin suna da nasu sakamako na musamman. Karanta ƙarin yadda amintaccen rosuvastatin yake. Ga mutanen da ke da haɗarin bugun zuciya da bugun jini, statins suna da kyau sosai fiye da lahani. Ya kamata a dakatar da wannan magani kawai idan har ba a iya magance cututtukan ba kuma ba zai yuwu a sauƙaƙe su ba. Hadarin matsalolin hanta an yi karin gishiri. Kada ku damu da su idan kun guji barasa. |
| Contraindications | Cutar hanta a cikin aiki mai aiki. Significantarin haɓakar enzymes na hanta ALT da AST a cikin jini. Rashin ƙarancin renal - keɓantaccen ƙarancin kere kere 30 ml / min. Hypersensitivity zuwa rosuvastatin ko tsofaffi waɗanda ke yin allunan. A cikin ƙasashen da ke magana da Rashanci, shekarun da ba su wuce 18 ana ɗaukar matakin contraindication ba, duk da cewa a ƙasashen waje, ana tsara shirye-shiryen rosuvastatin ga matasa tun daga shekaru 10. |
| Ciki da Shayarwa | Krestor, wasu kwayoyi na rosuvastatin da duk sauran statins suna contraindicated sosai a lokacin daukar ciki. Matan da suka isa haihuwa, wadanda aka yi masu da su ta hanyar gumaka, dole ne su yi amfani da abin da za'a iya kiyaye rigakafin. Idan ciki bai shirya ba, to shan kwaya don cholesterol ya kamata a dakatar da shi nan da nan. A waje na tushen magani tare da wannan magani, ba za ku iya shayar da nono ba. |
| Hulɗa da ƙwayoyi | Allunan kwafin Krestor suna ba da ma'amala mara kyau da wasu kwayoyi fiye da siffofin mutanen da suka gabata. Amma har yanzu hatsarin ya ci gaba. Akwai matsaloli tare da maganin rigakafi, masu tsara rigakafi, kwayoyin hana daukar ciki, masu tunani a jini, da sauran magunguna da yawa. Wannan na iya haifar da mummunar illa - ƙarancin hanta da aikin koda. Yi magana da likitanka! Kafin a sanya muku kwayar cutar mutum, ku gaya wa likitanka game da duk magunguna, abubuwan abinci masu gina jiki, da ganyayyaki da kuke sha. |
| Yawan abin sama da ya kamata | Babu takamaiman magani don yawan shan jini tare da Krestor. Likitocin suna ba da magani da kuma matakan tallafawa, sa ido kan aikin hanta da kuma matsayin aikin aikin phosphokinase. Hemodialysis baya taimakawa cire rosuvastatin daga jiki. |
| Umarni na musamman | Fara farawa tare da mutum-mutumi, ci gaba da bin tsarin abincin da kuma jagorantar rayuwa mai kyau. An bada shawara don kula da aikin koda koda yaushe ta amfani da gwaje-gwajen jini da fitsari. Idan an samo furotin a cikin fitsari ko kuma yawan haɗuwarsa, kula da likita. Idan kuna da ƙarancin ƙwayar thyroid, to, kada ku yi hanzarin ɗaukar statins, amma kuyi maganin hypothyroidism don dawo da cholesterol zuwa al'ada. Krestor da sauran magunguna na rosuvastatin suna ƙara yawan sukarin jini a cikin marasa lafiya da ke fama da ciwon sukari da kuma ciwon suga. |
| Fom ɗin saki | Allunan da aka sanya fim na 10, 20 da 40 MG. A cikin blisters daga laminate aluminum ko tsare, allunan 7 ko 14. A cikin fakitin kwali, 1, 2 ko 4 fitsari. |
| Sharuɗɗan da yanayin ajiya | Don adana a cikin busassun, da kariya daga haske, wurin, ba a wadata ga yara, a zazzabi baya sama da 30 ° C. Rayuwar shelf shine shekaru 3. |
| Abun ciki | Abubuwan da ke aiki shine alli na rosuvastatin. Wadanda suka kware - lactose monohydrate, MCC, phosphate alli, crospovidone, magnesium stearate. Harsashi na kwamfutar hannu shine lactose monohydrate, hypromellose, triacetin (glycerol triacetate), titanium dioxide, jan ƙarfe mai ruwan ƙarfe. |
Yawancin marasa lafiya suna so su maye gurbin maganin Krestor tare da wasu analog, mafi araha, suna da kayan aiki ɗaya. Bidiyo da ke ƙasa zai taimake ka. Dubi shi don yin zaɓin da ya dace a tsakanin allunan rosuvastatin da yawa da ake da su a kantin magani.
Crestor: sake dubawa
A rukunin yanar gizon da ke amfani da harshen Rashanci zaka iya samun dubun dubun bayanai game da Krestor na miyagun ƙwayoyi. Wadannan kwayoyin suna shahara, duk da tsananin farashin su. Lokacin da mutane suka rubuta bita akan wasu magunguna na rosuvastatin (Mertenil, Roxer, Rosucard), galibi suna korafi game da tasirin cutar. Nazarin game da Krestor na miyagun ƙwayoyi suna cike da korafe-korafe masu ma'ana game da tsadarsa. Amma authorsan marubutan ƙalilan suna ambaton sakamako masu illa. Masu sharhi a kan rukunin likitoci suna jin daɗin cewa asalin rosuvastatin miyagun ƙwayoyi sun saukar da kwalayen. Suna fushi kawai saboda yawan kuɗi da dole ne a biya su.
Marasa lafiya suna da tabbacin cewa tunda suna ɗaukar rosuvastatin mafi tsada, bazai sami sakamako ba ko kuma zasu zama ƙarancin. Maimakon zabar magungunan Krestor, zaɓi ƙwararrun ƙarancin analogues - Mertenil, Roxer, Rosucard ko wasu - mutane suna adana kuɗi. Koyaya, suna da yakinin cewa saboda ajiyar kuɗi zasu sami ƙarin tasirin sakamako. Kodayake binciken da aka sarrafa na placebo ya tabbatar da cewa wannan ba haka bane. Yawancin sakamako masu illa na mutum-mutumi da mutane ke korafi game da su a cikin sake duba su ana haifar da shi ne ta hanyar tunani mai zurfi na marasa lafiya, maimakon ainihin mummunan tasirin kwayoyi.
Alamu don amfani
Fredrickon na farko na hypercholesterolemia (nau'in IIa, gami da fampeal heterozygous hypercholesterolemia) ko kuma haɗin hypercholesterolemia (nau'in IIb) azaman ƙari ga abinci, lokacin da abinci da sauran hanyoyin rashin magani (kamar motsa jiki, asarar nauyi) sun kasa,
iyali na hyzycholesterolemia a matsayin kari ga abinci da sauran hanyoyin rage kiba (alal misali, LDL-apheresis) ko kuma a yanayin da irin wannan maganin bashi da inganci,
hypertriglyceridemia (nau'in IV a cewar Fredrickson) a matsayin ƙari ga abincin,
rage jinkirin ci gaban atherosclerosis, a ƙari ga abinci a cikin marasa lafiya waɗanda aka nuna musu jiyya don rage yawan ƙwayoyin cuta da LDL-C,
rigakafin farko na manyan rikice-rikice na zuciya da jijiyoyin jini (bugun jini, bugun zuciya, farfadowa na jijiya) a cikin marasa lafiyar marasa lafiya ba tare da alamun asibiti na cututtukan cututtukan zuciya ba, amma tare da haɓakar haɗarin ci gabanta (fiye da shekaru 50 na maza da kuma shekaru 60 na mata, ƙara yawan C-reactive furotin (≥2 mg / l) a gaban aƙalla ɗaya daga cikin ƙarin abubuwan haɗarin, kamar hauhawar jijiya, ƙara yawan maida hankali akan HDL-C, shan sigari, tarihin iyali game da farkon cutar cututtukan zuciya.
Tattaunawa game da Crestor na miyagun ƙwayoyi a cikin bayanan uwaye
Don kwatantawa, 'yan mata sun ba da kwayoyi biyu don rage cholesterol jini Krestor 10 MG Allunan No. 28 - 1337 rubles, abu mai aiki shine rosuvastatin, mai ƙira - AstraZeneca-IPR Pharmaceuticals Tevastor 10 mg Allunan No. 30 - 471 rubles, abu mai aiki shine rosuvastatin, mai ƙera - PHVMA / TEVA PHARMA Nan da nan ake iya gani. inda muke biyan sama da alama. Bayanai daga kantin magani & n.
. Mi karanta litattafai da yawa kan wannan batun yanzu. Rosehip yana da kyau don sha a cikin thermos da dare, akwai mai yawa bitamin, yana da amfani ga zuciya da tasoshin. . kuma da farko sun sha kwayoyi, yanzu mun sha gicciye.
Muna da Plavix (sau biyu a rana), Krestor, Kleksan (injections), ban iya tuna sauran ba, shi ma yana shan giya. Plavix a cikin polycl. a cikin Tatarstan an maye gurbinsa da Zilt - kuma a cikin Moscow an haramta shan madadin, saboda haka yana shan komai a ainihin - muna da wani wuri a cikin yanki na 20,000 rubles. yakan tafi kowace wata don magani.
Aauki wasu kwayoyi Krestor da Tevastor, hanyar da za a rage cholesterol jini a cikin marasa lafiya da atherosclerosis. Tevastor asalin halitta ne na Krestor kuma duka biyun sun dogara ne akan Rosuvastatin, Tevastor ya fi sau uku daraja kuma ba shi da ƙaranci ga Krestor, amma yana da alama. Anan gareshi da.
Cholesterol yana daɗaɗawa (sabili da haka, Krestor shima yana shan), saukar saukar da matsa lamba fiye da 100/60 ko 110/70, kamar nawa. Matakin farko na atherosclerosis a cikin ta. Omega tilasta shan wata daya da suka wuce, sha. Calcium d3 kuma yana shan ruwan sanyi. Ina tunani, Shin Krestor tare da Aspirin lafiya?
Oh, 'yan mata, da kyau da na ga waɗannan kwatancen. Zan yi masa alama. Na gode da bayanin mai amfani. Mahaifina ya yarda da gicciye kuma ko ta yaya hakan ya zama ɗan tsada a gare mu. Jessica, kuma baku san cewa ana iya amfani da Tevastor yanzu ba tare da takardar izinin likita ba, kawai farashin bambanci yana sananne sosai. Kuma wane tasiri bayan amfani da Tevastor daidai yake da p.
. Oy - wannan ya riga ya yi kyau sosai. Da alama babu wani abin da ba daidai ba tare da haɗakar waɗannan magungunan guda biyu. Aƙalla sau ɗaya sau ɗaya aka rubata mini maganin atherosclerosis tare da vasilip da aspirin tare. Kuma kamar yadda na fahimta, giciye da vasilip daga opera ɗaya. Gaskiya ne, ban sha ba - vasilip ba magani bane wanda zaku iya samun ciki :-)
Tasirin Tevastor daidai yake da na Crestor. bayan duk, magungunan duka suna da rosuvastatin abu mai aiki, amma Anya ya kamata a ɗauka kamar yadda likita ya umurce shi!
Tana shan gicciye (tevastor). rigakafin farko na manyan rikice-rikice na zuciya da jijiyoyin jini (bugun jini, bugun zuciya, farfadowa na jijiya) a cikin marasa lafiyar marasa lafiya ba tare da alamun asibiti na cututtukan cututtukan zuciya ba, amma tare da haɓakar haɗarin ci gabanta (fiye da shekaru 50 na maza da kuma shekaru 60 na mata, ƙara yawan C-reactive furotin (≥2 mg / l) a gaban aƙalla ɗaya daga cikin ƙarin abubuwan haɗari, kamar hauhawar jijiya, ƙaramin taro na HDL-C, shan sigari, fam.
Ban yi rashin lafiya ba Ina karantawa a yanar gizo, duka iri ɗaya, fibrinogen ɗinta ya yi yawa, har ma yana da shekaru. kuma duk muna da matsalolin jijiyoyin jiki a cikin dangi. kowa ya mutu daga wannan, ko daga cutar kansa. da ƙarfi: (Ina tsammanin za mu ƙara Aspirin-cardio zuwa Krestor? Ba shi da rauni. Babu cutar proromlasis a cikin krestor. Tana da ƙwayar cholesterol da farko atherosclerosis + tana murmushi
Pharmacology
Wani wakilin zubar da jini daga rukunin mutum-mutumi, mai hanawa na HMG-CoA reductase. Dangane da ka'idodin adawa da gasa, ƙwayar ƙwayar Statin yana ɗaure wa wannan sashin na coenzyme A receptor inda wannan enzyme yake. Wani sashin kwayar halittar statin yana hana canza hydroxymethylglutarate zuwa mevalonate, wani tsaka-tsaki a cikin kwayar kwayar cholesterol. Haramcin ayyukan HMG-CoA reductase yana haifar da jerin abubuwanda suka biyo baya, sakamakon hakan yana haifar da raguwa cikin abubuwan da ke cikin ƙwayar ƙwayar mahaifa da karuwar biyan diyya a cikin ayyukan masu karɓa na LDL kuma, a sakamakon haka, hanzarta catabolism na LDL cholesterol (Xc).
Sakamakon cututtukan jini na jikin mutum yana da alaƙa da raguwa a matakin jimlar cholesterol saboda ƙwayoyin LDL. Ragewar LDL ya dogara da kashi-kashi kuma ba layi bane, amma ingantacce.
Statins ba su shafi ayyukan lipoprotein da hepatic lipases, ba su da tasiri sosai a kan aikin haɗin gwal da catabolism na kitse mai kyauta, sabili da haka, tasirin su a matakin TG yana sakandare kuma kai tsaye ta hanyar manyan tasirin su akan rage darajar LDL-C. Rage matsakaici a cikin matakin TG yayin jiyya tare da statins yana da alama yana da alaƙa da bayyana ragowar (apo E) masu karɓa a farfaɗo na hepatocytes da ke da hannu a cikin catabolism na STDs, wanda ya ƙunshi kusan 30% TG.
Baya ga tasirin rage kiba, statins suna da tasirin gaske akan lalatawar ƙwayar cuta (alamomin farkon atherosclerosis), a jikin bango na jijiyoyin jini, yanayin atheroma, inganta ƙirar rheological jini, suna da maganin antioxidant, antiproliferative Properties.
An bayyana tasirin warkewa a cikin mako 1. bayan farkon farfajiya da kuma bayan sati 2 na jiyya shine 90% na mafi girman tasirin sakamako, wanda akasari yakan samu ne sati 4 sannan bayan hakan ya kasance kullum.
Pharmacokinetics
Bayan sarrafa baki Cmax Yana isa rosavastatin plasma a cikin awanni 5. Bioavailability ya kusan kashi 20%.
Rosuvastatin ya tara a cikin hanta. Vd - kimanin lita 134 Yin jingina ga ƙwayoyin plasma (galibi tare da albumin) kusan 90%.
Biotransforms zuwa ɗan ƙaramin abu (kusan 10%), kasancewa ba mai haɗaɗɗiyar maƙasudin ƙarfi ba don warewar abubuwa na tsarin cytochrome P450. Babban isoenzyme wanda ya shiga cikin metabolism na rosuvastatin shine CYP2C9. Isoenzymes CYP2C19, CYP3A4 da CYP2D6 ba su da yawa a cikin metabolism.
Babban gano metabolites na rosuvastatin sune N-dismethyl da lactone metabolites. N-dismethyl kusan 50% ba shi da aiki fiye da rosuvastatin, metabolites lactone ba su da magani.
Kusan 90% na kashi na rosuvastatin an cire shi da feces. Ragowar yana cikin fitsari. Plasma T1/2 - kimanin awa 19 T1/2 ba ya canzawa tare da ƙaruwa da yawa. Matsakaicin aikin plasma shine kusan 50 l / h (yana da banbancin bambanci 21.7%).
Kamar yadda yake a cikin sauran hanawar HMG-CoA-reductase, XC mai dauke da membrane yana da hannu a cikin haɓakar hepatic na rosuvastatin, wanda ke taka muhimmiyar rawa a cikin kawar hepatic na rosuvastatin.
Tsarin bayyanar rosuvastatin yana ƙaruwa daidai gwargwado.
A cikin marasa lafiya tare da mummunan gazawar renal (QC duka
Analogs Crestor
Yayi daidai da alamun
Farashin daga 54 rubles. Analog ne mai rahusa ta hanyar 606 rubles
Yayi daidai da alamun
Farashi daga 324 rubles. Analog ne mai rahusa ta hanyar 336 rubles
Yayi daidai da alamun
Farashin daga 345 rubles. Analog ne mai rahusa ta hanyar 315 rubles
Yayi daidai da alamun
Farashin daga 369 rubles. Analog ne mai rahusa ta hanyar 291 rubles
Yayi daidai da alamun
Farashin daga 418 rubles. Analog ɗin yana da rahusa ta hanyar 242 rubles
Yayi daidai da alamun
Farashin daga 438 rubles. Analog ɗin yana da rahusa ta 222 rubles
Yayi daidai da alamun
Farashin daga 604 rubles. Analog ne mai rahusa ta hanyar 56 rubles
Yayi daidai da alamun
Farashin daga 737 rubles. Analog ɗin ya fi tsada a 77 rubles
Yayi daidai da alamun
Farashin ya kasance daga 865 rubles. Analog ya fi tsada ta 205 rubles
Tsari sashi:
Kowane kwamfutar hannu ta ƙunshi abu mai aiki: rosuvastatin 10, 20 ko 40 mg a cikin nau'i na rosuvastatin alli.
Fitowa: lactose monohydrate 89.50 mg (don sashi na 10 mg), 179.00 (don maganin 20 mg), 164.72 mg (don sashi na 40 mg), ƙwayar microcrystalline 29.82 mg (don sashi na 10 mg), 59.64 mg (don sashi na 20 mg), 54.92 mg (don sashi na 40 mg), alli na phosphate 10,90 mg (don maganin 10 mg), 21.80 mg (don maganin 20 mg), 20.00 mg (na sashi 40 MG), crospovidone 7.50 MG (don sashi na 10 mg), 15.00 mg (don sashi na 20 mg), 15.00 mg (don maganin 40 mg), magnesium stearate 1.88 mg (don sashi na 10 mg) 3.76 MG (don sashi na 20 mg), 3.76 MG (don sashi na 40 mg), harsashi kwamfutar hannu: lactose monohydrate 1.80 MG (don sashi na 10 mg), 3.60 mg (don sashi na 20 mg), 3.60 mg (don sashi na 40 mg), hypromellose 1.26 mg (don sashi na 10 mg), 2.52 mg (don sashi na 20 mg), 2.52 mg (don sashi na 40 mg), triacetin (glycerol triacetate) 0.36 mg (don sashi na 10 mg), 0.72 mg (don sashi na 20 mg), 0.72 mg (don sashi na 40 MG), titanium dioxide 1.06 MG (don sashi na 10 mg), 2.11 mg (don sashi na 20 mg), 2.11 mg (don sashi na 40 mg), iron dye oxide ja 0.02 mg (don sashi na 10 mg), 0.05 MG (don sashi na 20 mg), 0.05 MG (don sashi na 40 mg).
Bayanin
Allunan 10 MG: zagaye, allunan biconvex, wanda aka shafe tare da membrane fim mai ruwan hoda, an zana shi da "ZD4522 10" a gefe ɗaya.
Allunan 20 MG: allunan biconvex zagaye, wanda aka shafe tare da membrane fim mai ruwan hoda, aka zana shi tare da "ZD4522 20" a gefe ɗaya.
Allunan 40 MG: otal, allunan biconvex, an rufe su da membrane fim mai ruwan hoda, an zana su da "ZD4522" a gefe guda kuma 40 a gefe.
Kayan magunguna
Hanyar aikin
Rosuvastatin mai hanawa ne, mai haɓaka mai hanawa na HMG-CoA reductase, enzyme wanda ke canza 3-hydroxy-3-methylglutaryl coenzyme A zuwa mevalonate, mai ƙirar cholesterol. Babban maƙasudin aikin rosuvastatin shine hanta, inda ake aiwatar da kwayar cholesterol (cholesterol) da kuma catabolism of low yawa lipoproteins (LDL).
Rosuvastatin yana ƙaruwa da yawan masu karɓa na “hanta” LDL akan farfajiyar tantanin halitta, da haɓaka haɓakawa da haɓakar LDL, wanda hakan yana haifar da hanawar haɗin lipoproteins mai ƙarancin ƙarfi (VLDL), don haka rage jimlar LDL da VLDL.
Pharmacodynamics
Krestor ® yana rage yawan kumburi na LDL cholesterol (cholesterol-LDL), jimlar cholesterol, triglycerides (TG), yana ƙara yawan ƙwayar lipoprotein mai ƙarfi (HDL-C), kuma yana rage taro na apolipoprotein B (ApoV), non-HDL cholest, -LVONP, TG-VLDLP kuma yana kara yawan kwantar da hankali na apolipoprotein AI (ApoA-I) (duba tebur 1 da 2), rage yawan rabo daga LDL-C / HDL-HDL, jimlar cholesterol / HDL-C da HDL-C / HDL-C da ApoB / ApoA-I rabo.
Tasirin warkewa yana tasowa a cikin sati daya bayan fara fargaba tare da Krestor ®, bayan makonni 2 na magani ya kai 90% na iyakar tasirin sakamako.
Matsakaicin tasirin warkewa shine mafi yawa ana samun shi ta mako na 4 na farji kuma an kiyaye shi tare da amfani da magani na yau da kullun.
Tebur 1 . Tasirin dose-dogara a cikin marasa lafiya da keɓaɓɓen hypercholesterolemia (nau'in IIa da IIb bisa ga Fredrickson) (matsakaiciyar sauyin da aka daidaita sau ɗaya idan aka kwatanta da ƙimar farko).
| Kashi | Biyu na marasa lafiya | HS-LDL | Janar cholesterol | HS-HDL | TG | HS-ba HDL | ApoV | ApoA-I |
| Waka | 13 | -7 | -5 | 3 | -3 | -7 | -3 | 0 |
| 10 MG | 17 | -52 | -36 | 14 | -10 | -48 | -42 | 4 |
| 20 MG | 17 | -55 | -40 | 8 | -23 | -51 | -46 | 5 |
| 40 MG | 18 | -63 | -46 | 10 | -28 | -60 | -54 | 0 |
Tebur 2 . Tasirin-dogaro a cikin marassa lafiya da ke ɗauke da ƙwayar jini (nau'in IIb da IV bisa ga Fredrickson) (ƙimar matsakaicin ƙaranci idan aka kwatanta da ƙimar farko).
| Kashi | Biyu na marasa lafiya | TG | HS-LDL | Janar cholesterol | HS-HDL | HS-ba HDL | HS-VLDLP | TG-lponp |
| Waka | 26 | 1 | 5 | 1 | -3 | 2 | 2 | 6 |
| 10 MG | 23 | -37 | -45 | -40 | 8 | -49 | -48 | -39 |
| 20 MG | 27 | -37 | -31 | -34 | 22 | -43 | -49 | -40 |
| 40 MG | 25 | -43 | -43 | -40 | 17 | -51 | -56 | -48 |
Ingancin asibiti Krestor ® yana da tasiri a cikin tsofaffi na marasa lafiya tare da hypercholesterolemia tare da ko ba tare da hypertriglyceridemia ba, ba tare da la'akari da launin fata, jinsi ko shekaru ba, ciki har da marasa lafiya masu ciwon sukari mellitus da familial hypercholesterolemia. A cikin 80% na marasa lafiya da ke dauke da nau'in IIa da IIb hypercholesterolemia bisa ga Fredrickson (matsakaiciyar farkon farawa na LDL-C shine kusan 4.8 mmol / L), yayin ɗaukar ƙwayar a cikin kashi 10 MG, maida hankali ne LDL-C ya kai ƙasa da 3 mmol / L.
A cikin marasa lafiya tare da heterozygous familial hypercholesterolemia suna karɓar Krestor ® a kashi 20-80 mg, an lura da ingantaccen tasiri na bayanan lipid (binciken da ya shafi marasa lafiya 435). Bayan titration zuwa kashi na yau da kullun na 40 MG (makonni 12 na jiyya), an lura da rage yawan LDL-C ta 53%. A cikin 33% na marasa lafiya, an cimma daidaituwa na LDL-C da ƙasa da 3 mmol / L.
A cikin marasa lafiya tare da hyzycholesterolemia na homozygous familial shan Krestor ® a kashi 20 na mg da 40 mg, matsakaicin raguwa a cikin taro na LDL-C shine 22%.
A cikin marasa lafiya tare da hypertriglyceridemia tare da maida hankali na farko na TG daga 273 zuwa 817 mg / dl wanda ya karbi Krestor ® a cikin kashi 5 MG zuwa 40 MG sau ɗaya a rana don makonni 6, an rage yawan yawan TG a cikin jini na jini (duba tebur 2 )
Ana lura da sakamako mai ƙari a hade tare da fenofibrate dangane da taro na triglycerides kuma tare da nicotinic acid a cikin rage ƙarancin lipid dangane da taro na HDL-C (duba mahimmin sashin "Umarni na Musamman").
A cikin binciken METEOR, ya shafi marasa lafiya 984 masu shekaru 45-70 shekaru tare da ƙarancin haɗarin haɓaka cututtukan zuciya na zuciya (CHD) (haɗarin shekaru 10 akan ma'aunin Framingham kasa da 10%), matsakaici LDL cholesterol maida hankali ne na 4.0 mmol / L (154.5 mg / dl) da ƙananan ƙananan ƙwayoyin atherosclerosis (wanda aka kimanta ta da kazamin carotid artery intima-media complex - TCIM) sunyi nazarin tasirin rosuvastatin akan kauri daga cikin hadaddun kafofin watsa labarai na intima. Marasa lafiya sun karɓi rosuvastatin a kashi 40 MG / rana ko placebo na shekaru 2.
Rosuvastatin farjin magani ya rage saurin ci gaba na matsakaicin TCIM don kashi 12 na ƙwayar carotid idan aka kwatanta da placebo tare da bambancin -0.0145 mm / shekara 95% amincewa tazara daga -0.0196 zuwa -0.0093, p ® 40 mg ba da shawarar ba. Ya kamata a yi amfani da kashi 40 na MG a marasa lafiya da ke fama da matsanancin rashin ƙarfi da kuma haɗarin kamuwa da cuta da jijiyoyin jini (CVD).
Sakamakon binciken JUPITER (Dalilin amfani da mutum-mutumi don rigakafin farko: binciken shiga tsakani yana kimanta rosuvastatin) a cikin marasa lafiya 17802 ya nuna rosuvastatin ya rage hadarin cututtukan zuciya (252 a cikin rukunin placebo idan aka kwatanta da 142 a rukunin rosuvastatin kungiyar) (p An lura da ingancin maganin rashin lafiya bayan watanni 6 na farko na amfani da miyagun ƙwayoyi, an sami raguwar ƙididdigar yawan kashi 48% cikin haɗuwa, ciki har da mutuwa daga cututtukan zuciya, insulin. m da tsokar zuciya infarction (Hazard rabo: 0,52, 95% amincewa tazara 0,40-0,68, p ® a yara a karkashin shekaru 18 da haihuwa.
Marasa lafiya tare da raunin hanta
Babu bayanai ko gogewa tare da amfani da miyagun ƙwayoyi a cikin marasa lafiya tare da maki sama da 9 akan sikelin-Yara (duba sassan "Magunguna" da "Umarni na Musamman").
Sashi da gudanarwa
A ciki, kar a tauna ko nika kwamfutar hannu, hadiye duka, a wanke da ruwa. Ana iya tsara magungunan a kowane lokaci na rana, ba tare da la'akari da yawan abincin ba.
Kafin fara jiyya tare da Krestor ®, mai haƙuri ya kamata ya fara bin daidaitaccen tsarin abincin da ke ciwan jiki da ci gaba da bin sa yayin jiyya. Ya kamata a zaɓi kashi na miyagun ƙwayoyi daban-daban dangane da makasudin aikin likita da kuma maganin warkewa ga magani, yin la’akari da shawarwari na yanzu kan maƙasudin ƙwayar lipids.
Thewarin da aka ba da shawarar farawa ga marasa lafiya da ke fara shan maganin, ko don marasa lafiya da aka canjawa wuri daga shan sauran hanyoyin hanawa na HMG-CoA, ya kamata ya zama 5 ko 10 MG na Krestor ® sau ɗaya a rana. Lokacin zaɓin kashi na farko, mutum yakamata ya jagoranci jagorancin yawan ƙwayoyin cuta da yin la'akari da haɗarin haɗarin cututtukan zuciya, kuma lallai ne a tantance yiwuwar haɗarin sakamako masu illa. Idan ya cancanta, ana iya ƙara adadin zuwa mafi girma bayan makonni 4 (duba sashin "Pharmacodynamics").
Dangane da yiwuwar haɓaka tasirin sakamako yayin ɗaukar kashi 40 MG, idan aka kwatanta da ƙananan allurai na miyagun ƙwayoyi (duba sashi "Side effects"), kara kashi zuwa 40 MG bayan ƙarin kashi ya fi yadda aka bada shawarar farko na makonni 4 Za'a iya aiwatar da maganin kawai a cikin marasa lafiya tare da mummunan hypercholesterolemia da haɗarin haɗari na rikicewar zuciya (musamman a cikin marasa lafiya da familial hypercholesterolemia) waɗanda ba su cimma sakamakon da ake buƙata ba yayin yin amfani da kashi 20 na MG, kuma wanene zai zama a karkashin gwani dubawa (gani. "Special Umarnin" sashe).
Musamman saka idanu akan marasa lafiya da suke karbar maganin a cikin kashi 40 MG ana bada shawara.
Ba a bada shawarar sashi na 40 mg ba ga marasa lafiya wadanda basuyi tuntuɓar likita ba.
Bayan makonni 2-4 na ilmin likita da / ko tare da karuwa a cikin kashi na shiri na Krestor,, saka idanu na metabolism na lipid ya zama dole (gyara kashi ya zama dole idan ya cancanta).
Tsofaffi marasa lafiya
Ba a buƙatar gyaran gyaɗa.
Marasa lafiya tare da gazawar koda
A cikin marassa lafiya da gazawar sassaucin matsakaici ko matsakaici, ba a buƙatar daidaita sashi. A cikin marasa lafiya da gajiya mai yawa game da koda (CC kasa da 30 ml / min.), Amfani da miyagun ƙwayoyi Krestor ® yana contraindicated.
Yin amfani da miyagun ƙwayoyi a cikin kashi 40 MG yana cikin contraindicated a cikin marasa lafiya da ke fama da rauni na matsakaici aiki (CC kasa da 30-60 ml / min.) (Dubi sashin "Umarni na Musamman" da "Pharmacodynamics"). Ga marasa lafiya da ke fama da rauni na matsakaita aiki, ana bada shawarar farko na 5 mg.
Marasa lafiya tare da raunin hanta
Krestor ® yana cikin contraindicated a cikin marasa lafiya da cutar hanta a cikin aiki mai aiki (duba sashe "Contraindications").
Al'umma na Musamman. Kabilun kabilu
Lokacin da aka yi nazarin sigogin magunguna na rosuvastatin a cikin marasa lafiya na kabilu daban-daban, an lura da karuwa cikin tsarin rosuvastatin tsakanin Jafananci da Sinanci (duba sashin "Umarni na Musamman"). Ya kamata a yi la'akari da wannan gaskiyar yayin rubuta Krestor ® ga waɗannan rukunin masu haƙuri. Lokacin da ake tsara allurai na 10 da 20 MG, shawarar farko da aka bayar ga marasa lafiya na tseren Mongoloid shine 5 MG. Gudanar da miyagun ƙwayoyi a cikin kashi 40 MG ne contraindicated ga marasa lafiya na tseren Mongoloid (duba sashin "Contraindications").
Halittar kwayoyin halitta
Masu ɗaukar hoto na genotypes SLC01B1 (OATP1B1) c.521CC da ABCG2 (BCRP) c.421AA sun nuna karuwa a fallasa (AUC) zuwa rosuvastatin idan aka kwatanta da masu ɗaukar hoto na genotypes SLC01B1 c.521TT da ABCG2 c.421CC. Ga marasa lafiya da ke ɗauke da genotypes c.521CC ko c.421AA, mafi girman shawarar da ake bayarwa na Crestor ® shine 20 MG sau ɗaya a rana (duba sassan "Magunguna", "Umurni na Musamman" da "Haɓakawa tare da Wasu Magunguna da Sauran nau'ikan Haɗin Cutar Drug" )
Myopathy-yiwuwa marasa lafiya
Gudanar da miyagun ƙwayoyi a cikin kashi 40 MG an contraindicated a cikin marasa lafiya tare da abubuwan da zasu iya nuna tsinkayar ci gaban myopathy (duba sashin "Contraindications"). Lokacin da aka tsara allurai na 10 da 20 MG, shawarar farko da aka bayar don wannan rukuni na marasa lafiya shine 5 MG (Dubi sashin "Contraindications")
Gudanar da aikin likita
Rosuvastatin yana ɗaure wa furotin na sufuri daban-daban (musamman, OATP1B1 da BCRP). Lokacin da aka haɗa shi tare da Krestor ®, tare da kwayoyi (kamar cyclosporine, wasu masu hana HIV kariya, ciki har da haɗuwa da ritonavir tare da atazanavir, lopinavir da / ko tipranavir), wanda ke kara yawan rosuvastatin a cikin jini saboda hulɗa tare da sunadaran jigilar kayayyaki, haɗarin myopathy (ciki har da rhabdomyolysis) (duba sassan "Umarni na Musamman" da "hulɗa tare da wasu kwayoyi da sauran nau'ikan hulɗa na miyagun ƙwayoyi"). Ya kamata ku karanta umarnin don amfani da waɗannan magungunan kafin alƙawarirsu a hade tare da maganin Krestor ®. A irin waɗannan halayen, yakamata ku kimanta yiwuwar rubuta magani na madadin magani ko dakatar da amfani da miyagun ƙwayoyi na Krestor temporarily na ɗan lokaci. Idan yin amfani da magungunan da ke sama ya zama dole, yakamata ku kimanta rabo da fa'idar haɗarin haɗuwa tare da maganin Crestor ® kuma kuyi tunanin yiwuwar rage adadin sa (duba ɓangaren "hulɗa tare da wasu kwayoyi da sauran nau'ikan hulɗa na miyagun ƙwayoyi").
Side sakamako
Abubuwan da ba a san su ba suna faruwa lokacin shan miyagun ƙwayoyi Krestor ® yawanci m ne kuma suna barin kansu. Kamar yadda yake tare da sauran masu hanawa HMG-COL, hanawar sakamako masu illa shine yawanci ya dogara da su.
Ana gabatar da tasirin mummunar illa kamar haka:
sau da yawa (> 1/100, 1/1000, 1/10000, ®, proteinuria za a iya ganowa. Canje-canje a cikin adadin furotin a cikin fitsari (daga rashi ko ragi mai yawa zuwa ++ ko fiye) ana lura da ƙasa da 1% na marasa lafiya da suke karɓar 10-20 mg miyagun ƙwayoyi, kuma a cikin kusan 3% na marasa lafiya suna karɓar 40 MG na magani.
An ɗan sami ɗan canje-canje a cikin adadin furotin a cikin fitsari lokacin shan kashi na 20 MG. A mafi yawancin halayen, proteinuria yana raguwa ko ya ɓace yayin jiyya kuma baya nufin faruwar cutar ko cutar cututtukan koda.
Daga tsarin musculoskeletal
Lokacin amfani da miyagun ƙwayoyi Krestor ® a cikin dukkan sashi, kuma musamman lokacin shan allurai na ƙwayoyi fiye da 20 MG, an ba da rahoton sakamako masu zuwa akan tsarin musculoskeletal: myalgia, myopathy (gami da myositis), a cikin lokuta mafi ƙarancin gaske, rhabdomyolysis tare da ko ba tare da gazawar ƙarancin renal nata.
Observedara yawan dogaro-da-kashi akan aikin creatine phosphokinase (CPK) an lura da shi a cikin adadi kaɗan na marasa lafiya da ke shan rosuvastatin. A mafi yawan lokuta, ya kasance mai sauƙi, asymptomatic da na ɗan lokaci. Game da ƙara yawan aiki na CPK (fiye da sau 5 idan aka kwatanta da babba na al'ada), ya kamata a dakatar da maganin (duba sashe "Umarni na Musamman").
Daga hanta
Lokacin amfani da rosuvastatin, ana ganin karuwar kwayar-kumburi a cikin ayyukan “hanta” transaminases a cikin karamin adadin marasa lafiya. A mafi yawan lokuta, ba shi da mahimmanci, asymptomatic da na ɗan lokaci.
Manuniyar dakin gwaje-gwaje
Lokacin amfani da miyagun ƙwayoyi Krestor ®, an kuma lura da canje-canje masu zuwa a cikin sigogin gwaje-gwaje: karuwa a cikin taro na glucose, bilirubin, ayyukan gamma-glutamyl transpeptidase, alkaline phosphatase, da lalata daskarar thyroid.
Aikace-aikacen tallace-tallace
An ba da rahoton abubuwan da suka biyo baya sakamakon amfani da Krestor post bayan cinikin kasuwanci:
Daga tsarin jini
Mitar da ba'a tantance ba: thrombocytopenia
Daga narkewa
Da wuya sosai: jaundice, hepatitis
Da wuya: ƙarin ayyukan “hanta” transaminases
Ba a tantance mita ba: zawo
Daga tsarin musculoskeletal
Da wuya sosai: arthralgia
Unspecified mita: immuno-matsakaici necrotizing myopathy
Daga tsarin juyayi na tsakiya
Da wuya sosai: asarar ƙwaƙwalwa ko asara
Matsakaicin rashin tabbas: neuropathy na yanki
Daga tsarin numfashi
Unspecified mita: tari, shortness na numfashi
Daga tsarin urinary
Da wuya sosai: hematuria
A ɓangaren fata da kitsen mai kitse
Makon da ba a bayyana ba: cutar Stevens-Johnson
Daga tsarin haihuwa da gyada mai shayarwa
Unspecified mita: gynecomastia
Sauran
Unspecified mita: na gefe edema
Lokacin amfani da wasu gumaka, alamominda suka biyo baya sun ruwaito:
rashin jin daɗi, hargitsi na bacci, gami da rashin bacci da mafarkai "mafarki mai ban tsoro", lalatawar jima'i, hauhawar jini, haɓakar haɓakar glycosylated.
An ba da rahoton abubuwan da ke cikin cututtukan cututtukan huhu na kewayon cuta, musamman tare da tsawan magunguna (duba sashe "Umarni na Musamman").
Yawan abin sama da ya kamata
Tare da gudanar da aikin kai-tsaye na yawancin allurai na yau da kullun, sigogi na pharmacokinetic na rosuvastatin ba su canzawa.
Babu takamaiman magani don yawan abin da ke cikin rosuvastatin. Game da yawan abin sama da ya kamata, ana bada shawarar gudanar da aikin tiyata da matakan da suke bi don kiyaye ayyukan gabobin jiki da tsarinsu. Kulawa da aikin hanta da matakan CPK ya zama dole. Kwantar da hankalin mutum baiyi tasiri ba.
Yin hulɗa tare da wasu kwayoyi da sauran nau'ikan hulɗa na miyagun ƙwayoyi
Sakamakon amfani da wasu magunguna akan rosuvastatin
Masu kare lafiyar sunadaran sufuri: rosuvastatin yana ɗaure wa wasu sunadarai na sufuri, musamman, OATP1B1 da BCRP. Amfani da magunguna waɗanda ke hana waɗannan kariyar sufuri na iya haɗuwa tare da haɓaka da ƙwayar plasma na rosuvastatin da haɓakar haɗarin kamuwa da cutar sankarar zuciya (duba tebur 3 da kuma sassan “Sashi da gudanarwa” da “Umarni na Musamman”).
Sankarin: tare da amfani da rosuvastatin da cyclosporine a lokaci guda, AUC na rosuvastatin ya kasance matsakaita sau 7 fiye da yadda aka lura a cikin masu sa kai na lafiya (duba tebur 3). Ba ya tasiri a cikin ƙwayar plasma na cyclosporine. Krestor ® yana cikin contraindicated a cikin marasa lafiya shan cyclosporine (duba sashin "Contraindications").
Imwafin munarfin Lafiya na Humanan Adam (HIV) kodayake ba a san ainihin hanyar ma'amala ba, haɗin gwiwar masu hana kariyar kwayar cutar kwayar cutar HIV na iya haifar da ƙaruwa a cikin bayyanar cutar rosuvastatin (duba tebur 3).
Nazarin pharmacokinetic na yin amfani da 20 MG na rosuvastatip na lokaci guda tare da shirye-shiryen haɗaka wanda ya ƙunshi masu hana masu kariya biyu na kwayar cutar HIV (400 MG na lopinavir / 100 MG na ritonavir) a cikin masu sa kai na lafiya ya haifar da kusan ninki biyu da sau biyar a cikin AUC (0-24) da Cmax na rosuvastatin, bi da bi. Sabili da haka, ba a ba da shawarar gudanar da aikin rosuvastatin da masu hana kwayar cutar ta kariya ba (duba sassan "Sashi da Gudanarwa", "Umarnin na Musamman", tebur 3).
Gemfibrozil da sauran magunguna masu rage kiba: haɗewar amfani da rosuvastatin da gemfibrozil yana haifar da ƙaruwa sau biyu a cikin mafi girman maida hankali na rosuvastatin a cikin jini na jini da AUC na rosuvastatin (duba sashin "Umarni na Musamman"). Dangane da bayanai kan takamaiman ma'amala, ba a sa ran ma'amala tsakanin gwamnatoci da fenofibrate, hulɗar magunguna zai yiwu.
Gemfibrozil, fenofibrate, sauran fibrates, da kuma rage rage kiba na nicotinic acid sun kara haɗarin cutar myopathy lokacin da aka yi amfani da su tare da masu hana haɓaka HMG-CoA, mai yiwuwa saboda gaskiyar cewa zasu iya haifar da myopathy lokacin amfani dasu a cikin maganin monotherapy (duba sashe na "Umarnin na Musamman") . Yayin shan magungunan tare da gemfibrozil, fibrates, acid nicotinic acid a cikin rage ƙwayar lipid (fiye da 1 g / rana), ana ba da shawarar marasa lafiya wani kashi na farko na 5 MG, wani kashi na 40 mg yana contraindicated a cikin haɗin gwiwa tare da fibrates (duba sassan "Contraindications", " Sashi da gudanarwa "," Umarnin na musamman ").
Ezetimibe: amfani da miyagun ƙwayoyi na lokaci guda Krestor ® a cikin kashi 10 na mg da ezetimibe a kashi na 10 mg yana haɗuwa tare da karuwa a cikin AUC na rosuvastatin a cikin marasa lafiya tare da hypercholesterolemia (duba tebur 3). Ba shi yiwuwa a fitar da haɗarin haɗarin sakamako masu illa sakamakon hulɗa da magunguna tsakanin Krestor drug da ezetimibe.
Antacids: amfani da rosuvastatin na lokaci daya da dakatarwar antacids wadanda ke dauke da sinadarin magnesium da hydroxide na aluminium, yana haifar da raguwa a cikin rosavastatin plasma da kimanin 50%. Ba a faɗi wannan tasirin idan an yi amfani da antacids awanni 2 bayan shan rosuvastatin. Ba a yi nazarin mahimmancin asibiti na wannan hulɗa ba.
Kashiram: amfani da rosuvastatin da erythromycin lokaci guda yana haifar da raguwa a cikin AUC na rosuvastatin da 20% da Cmax na rosuvastatin da 30%. Irin wannan hulɗar na iya faruwa sakamakon karuwar motsin hanji wanda ya haifar da yawan haɗarin erythromycin.
Cytochrome P450 Isofermeitis: Sakamakon bincike na vivo da in vitro sun nuna cewa rosuvastatin ba mai hanawa bane kuma mai samar da injiniya ne na cytochrome P450. Bugu da kari, rosuvastatin gurbataccen gurbi ne na wadannan isoenzymes. Saboda haka, hulɗa na rosuvastatin tare da wasu kwayoyi a matakin na rayuwa wanda ya shafi cytochrome P450 isoenzymes ba a tsammanin.
Babu wata babbar hulɗar asibiti a cikin rosuvastatin tare da fluconazole (mai hana isoenzymes CYP2C9 da CYP3A4) da ketoconazole (mai hana inginenymym CYP2A6 da CYP3A4).
Fusidic acid: ba a gudanar da bincike don nazarin hulɗar rosuvastatin da fusidic acid ba. Kamar yadda yake tare da sauran mutum-mutumi, an karɓi rahoton tallace-tallace na rhabdomyolysis tare da haɗin gwiwar gudanar da rosuvastatin da fusidic acid. Wajibi ne a kula da marasa lafiya a hankali. Idan ya cancanta, dakatar da rosuvastatin na ɗan lokaci zai yiwu.
Yin hulɗa tare da kwayoyi waɗanda ke buƙatar daidaita kashi na rosuvastatin (duba tebur 3)
Ya kamata a daidaita magungunan Krestor ® idan ya cancanta, yin amfani da shi tare da kwayoyi waɗanda ke kara haɗarin cutar rosuvastatin. Ya kamata ku karanta umarnin don amfani da waɗannan magungunan kafin alƙawarirsu a hade tare da maganin Krestor ®. Idan ana tsammanin karuwa game da bayyanar sau 2 ko sama da haka, kashi na farko na shirye-shiryen Crestor ® ya zama 5 MG sau ɗaya a rana. Matsakaicin adadin Krestor ® na yau da kullun ya kamata kuma a daidaita shi don ɗaukar tsammanin fallasa zuwa rosuvastatin bai wuce wancan na kashi 40 na MG da aka ɗauka ba tare da kulawa na lokaci guda na magungunan da ke hulɗa da rosuvastatin. Misali, matsakaicin maganin yau da kullun na Crestor ® tare da amfani da lokaci daya tare da gemfibrozil shine 20 MG (haɓakawa ta hanyar sau 1.9), tare da ritonavir / atazanavir - 10 MG (karuwar bayyanuwa shine sau 3.1).
Tebur 3 . Sakamakon aikin kwantar da hankali a kan bayyanar rosuvastatin (AUC, ana nuna bayanan cikin tsari na raguwa) - sakamakon gwaje gwaje na asibiti da aka buga.
| Yanayi mai alaƙa hanyoyin kwantar da hankali | Yanayin saukarwa rosuvastatin | Canji AUC rosuvastatin |
| Cycloporin 75-200 mg Sau 2 a rana., Watanni 6. | 10 MG sau ɗaya a rana., 10 days | Karuwa 7.1x |
| Atazanavir 300 MG / ritonavir 100 MG 1 lokaci kowace rana., 8 days | 10 MG kashi daya | 3.1x karuwa |
| Simeprevir 152 MG 1 lokaci kowace rana., 7 kwana | 10 MG kashi daya | 2.8x karuwa |
| Lopinavir 400 MG / ritonavir 100 MG Sau 2 a rana., Kwana 17 | 20 MG sau 1 a rana., Kwana 7 | Sau 2.1 yana ƙaruwa |
| Clopidogrel 300 MG (ana amfani da kashi) sannan 75 MG bayan awa 24 | 20 MG guda daya kashi | 2x karuwa |
| Gemfibrozil 600 MG Sau 2 a rana., Kwana 7 | 80 MG guda daya kashi | Karuwa 1.9x |
| Eltrombopag 75 MG Lokaci 1 a rana. 10 days | 10 MG kashi daya | 1.6x karuwa |
| Darunavir 600 MG / ritonavir 100 MG Sau 2 a rana., Kwana 7 | 10 MG sau 1 a rana., Kwana 7 | Sau 1.5 yana ƙaruwa |
| Tipranavir 500 MG / ritonavir 200 MG Sau 2 a rana., Kwana 11 | 10 MG kashi daya | Sau 1.4 yana ƙaruwa |
| Dronedarop 400 MG Sau 2 a rana. | Babu bayanai | Sau 1.4 yana ƙaruwa |
| Itraconazole 200 MG 1 lokaci kowace rana., 5 days | 10 MG ko 80 MG sau ɗaya | Sau 1.4 yana ƙaruwa |
| Ezetimibe 10 MG 1 lokaci a rana., Kwanaki 14 | 10 MG sau ɗaya a rana, kwanaki 14 | Sau 1.2 yana ƙaruwa |
| Fosamprenavir 700 MG / ritonavir 100 MG Sau 2 a rana., Kwanaki 8 | 10 MG kashi daya | Babu canzawa |
| Aleglitazar 0.3 MG. Kwana 7 | 40 MG, kwana 7 | Babu canzawa |
| Silymarin 140 MG Sau 3 a rana. 5 days | 10 MG kashi daya | Babu canzawa |
| Fenofibrate 67 MG Sau 3 a rana., Kwana 7 | 10 MG, kwana 7 | Babu canzawa |
| Rifampin 450 MG Sau ɗaya a rana. Kwana 7 | 20 MG guda daya kashi | Babu canzawa |
| Ketoconazole 200 MG Sau 2 a rana., Kwana 7 | 80 MG guda daya kashi | Babu canzawa |
| Fluconazole 200 MG 1 lokaci kowace rana., Kwana 11 | 80 MG guda daya kashi | Babu canzawa |
| Erythromycin 500 MG Sau 4 a rana., Kwana 7 | 80 MG guda daya kashi | 28% raguwa |
| Baikalin 50 MG Sau 3 a rana., Kwanaki 14 | 20 MG guda daya kashi | 47% raguwa |
Tasirin rosuvastatin akan sauran kwayoyi
Antioxists na Vitamin K: ƙaddamar da aikin rosuvastatin far ko karuwa a cikin kashi a cikin marasa lafiya da ke karɓar maganin antagonists na Vitamin guda (misali, warfarin) na iya haifar da karuwa a cikin Harkokin Normalized International (MHO). Daukewar rosuvastatin ko ragewa a cikin maganin zai iya haifar da raguwa a cikin MHO. A irin waɗannan halayen, ana ba da shawarar sarrafa MHO.
Na maganin hana haihuwa / maganin maye gurbin maganin: yin amfani da rosuvastatin da na hana haihuwa na zamani yana kara AUC na ethinyl estradiol da AUC na norgestrel da 26% da 34%, bi da bi. Irin wannan karuwa a cikin ƙwayar plasma ya kamata a la'akari yayin zaɓin sashi na maganin hana haihuwa.
Bayanain magunguna na Pharmacokinetic akan amfani da maganin Krestor ® na lokaci daya da maganin maye gurbin maye, saboda haka, ba za a iya cire irin wannan sakamako tare da amfani da wannan haɗin ba. Koyaya, wannan haɗin an yi amfani dashi sosai yayin gwaji na asibiti kuma haƙuri yana da haƙuri sosai.
Sauran magunguna: Babu wata muhimmiyar hulɗa ta rosuvastatin tare da digoxin ana tsammanin.
Umarni na musamman
Tasirin sakamako
A cikin marasa lafiyar da suka karɓi kaso na Krestor ® (galibi 40 MG), an lura da tubular proteinuria, wanda a mafi yawancin lokuta na lokaci ne. Irin wannan furotin ba a nuna cutar koda ko ciwan koda ba. A cikin marasa lafiya da ke shan maganin a gwargwadon kashi 40 MG, ana bada shawara don saka idanu akan alamun alamun aiki a lokacin jiyya.
Daga tsarin musculoskeletal
Lokacin amfani da miyagun ƙwayoyi Krestor ® a cikin dukkan sashi, kuma musamman lokacin shan allurai na ƙwayoyi fiye da 20 MG, an ba da rahoton abubuwan da suka biyo baya a kan tsarin musculoskeletal: myalgia, myopathy, a cikin mafi yawan lokuta, rhabdomyolysis.
Tabbatar da ƙirar halittar phosphokinase
Ba a aiwatar da ƙudurin CPK bayan matsanancin ƙoƙari na jiki ko kuma idan akwai wasu dalilai masu yiwuwar karuwar CPK, wanda zai haifar da fassarar da ba daidai ba game da sakamakon. Idan matakin farko na CPK yana ƙaruwa sosai (sau 5 sama da iyakar ƙimar ƙa'idar aiki), ya kamata a aiwatar da maimaita ma'auni bayan kwanaki 5-7. Bai kamata a fara amfani da magani ba idan gwajin maimaitawa ya tabbatar da matakin farko na CK (fiye da sau 5 sama da iyakar babba na al'ada).
Kafin farawan magani
Lokacin rubuta Krestor ®, har ma lokacin da ake tsara sauran masu hana HMG-CoA reductase, ya kamata a yi taka tsantsan a cikin marasa lafiya tare da halayen haɗari na halin yanzu don myopathy / rhabdomyolysis (duba sashin "Gargaɗi"), ya zama dole a yi la’akari da haɗarin haɗari da kuma yiwuwar illolin cutar da asibiti kallo.
A lokacin jiyya
Sanar da mara lafiya game da bukatar sanar da likita kai tsaye game da shari'o'in fara jin rauni na tsoka, rauni na tsoka ko gauraya, musamman a hade da zazzabin cizon sauro. A cikin irin waɗannan marasa lafiya, ya kamata a ƙaddara matakin CPK. Yakamata a dakatar da aikin idan matakin CPK ya ƙaru sosai (fiye da sau 5 idan aka kwatanta da iyakar ƙimar al'ada) ko kuma idan an bayyanar da alamun tsokoki kuma yana haifar da rashin kwanciyar hankali yau da kullun (koda kuwa matakin CPK ya ninka sau 5 ƙasa da babba. iyaka na al'ada). Idan bayyanar cututtuka ta ɓace kuma matakin CPK ya koma al'ada, ya kamata a ba da kulawa don sake sake sarrafa magungunan Krestor ® ko sauran hanawar rage girman HMG-CoA a cikin ƙananan matakan tare da saka idanu na mai haƙuri.
Kulawa da CPK na yau da kullun yayin rashin bayyanar cututtuka ba shi da amfani.
Yawancin lokuta masu wuya na rigakafi da tsaka-tsakin necrotizing myopathy tare da alamun bayyanar cututtuka a cikin nau'i na rauni mai ƙarfi na tsokoki mai haɓaka da haɓaka matakin CPK a cikin jijiyoyin jini yayin jiyya ko lokacin ɗaukar mutum-mutumi, gami da rosuvastatin. Ana iya buƙatar ƙarin nazarin ƙwayar tsoka da ƙwayar jijiya, nazarin serological, kazalika da maganin hana daukar ciki.
Babu alamun alamun kara yawan jijiyoyin jiki yayin daukar Krestor ® da maganin kwantar da hankali. Koyaya, karuwa a cikin abin da ya faru na myositis da myopathy a cikin marasa lafiya suna shan sauran inhibitors, HMG-CoA reductase a hade tare da abubuwan fibric acid, wanda ya hada da gemfibrozil, cyclosporin, nicotinic acid, antizozal antifungal, kariya ta hanawa da kuma maganin rigakafin macrolide. Gemfibrozil yana kara haɗarin kamuwa da cutar sankarar mahaifa yayin da aka haɗa shi da wasu hanawar hanaɗa HMG-CoA. Saboda haka, ba a bada shawarar gudanar da aikin na lokaci ɗaya na miyagun ƙwayoyi Krestor ® da gemfibrozil ba. Yankin hadarin don amfanin da yakamata yakamata a yi amfani dashi akai yayin amfani da shirye-shiryen Crestor together tare da fibrates ko ƙarancin rage yawan sinadarin nicotinic acid. Yin amfani da miyagun ƙwayoyi Krestor ® a cikin kashi 40 MG tare da fibrates an contraindicated. (duba sassan "hulɗa tare da wasu kwayoyi da sauran nau'ikan hulɗa na miyagun ƙwayoyi", "Contraindications").
Makonni 2-4 bayan fara magani da / ko tare da karuwa a cikin kashi na shiri na Krestor ®, saka idanu na metabolism na lipid ya zama dole (gyara kashi ya zama dole idan ya cancanta).
A hanta
An bada shawara don ƙididdigar alamun alamun hanta kafin farawa da kuma watanni 3 bayan farawa. Shan magungunan Krestor ® ya kamata a dakatar dashi ko kuma a rage yawan maganin idan kwazon aikin transaminase a cikin jini ya ninka har sau 3 sama da yadda aka saba.
A cikin marasa lafiya da hypercholesterolemia saboda hypothyroidism ko ciwo nephrotic, ya kamata a gudanar da lura da cututtukan cututtukan cututtuka kafin a yi amfani da maganin Crestor ®.
Al'umma na Musamman. Kabilun kabilu
Yayin gudanar da karatun kantin magani na likitancin kasar Sin da Jafananci, an lura da karuwar tsarin rosuvastatin idan aka kwatanta da alamu da aka samu a tsakanin marasa lafiyar Turai (duba sassan "Sashi da Gudanarwa" da "Pharmacokinetics").
Kare masu hana
Ba a bada shawarar haɗakar amfani da miyagun ƙwayoyi tare da masu hana kariya ba (duba sashe "hulɗa tare da wasu kwayoyi da sauran nau'ikan hulɗa").
Lactose
Bai kamata a yi amfani da maganin ba a cikin marasa lafiya da rashi lactase, rashin haƙuri na galactose da glucose-galactose malabsorption.
Cutar kuturta
Lokacin amfani da wasu mutum-mutumi, musamman na dogon lokaci, an samu rahoton yaɗuwar cutar cututtukan huhun da ke tsakanin su. Bayyananniyar cutar na iya haɗawa da gajeruwar numfashi, tari, mara amfani, da walwala gaba ɗaya (rauni, nauyi, da zazzabi). Idan ana zargin cutar cututtukan huhu da juna, ya kamata a daina maganin dattin.
Type 2 ciwon sukari
A cikin marasa lafiya tare da taro na glucose na 5.6 zuwa 6.9 mmol / L, ana amfani da maganin Crestor ® tare da haɓakar haɗarin kamuwa da nau'in 2.
Tasiri kan iya tuƙin mota da sauran hanyoyin
Babu wani binciken da aka gudanar don nazarin sakamakon shiri na Krestor ® akan iya tuƙin abin hawa da amfani da hanyoyin. Koyaya, dangane da kayan aikin magunguna, Krestor ® bai kamata ya sami wannan tasiri ba. Yakamata a yi taka tsantsan yayin tuki mota ko aiki da ke da alaƙa da ƙara jawo hankali da amsawar psychomotor (ƙaiƙayi na iya faruwa a yayin warkarwa).
Saboda yawan ƙwayoyin cuta, likitana ya ba da umarnin Krestor da farko 5
Sakamakon ƙwayar ƙwayar cuta, likitana ya ba da umarnin Krestor da farko 5 MG, sannan ya ƙara kashi zuwa 10 MG. Wasan kwaikwayon ya zama mafi kyau. Shekaru 3, gwajin aikin hanta na yau da kullun ya nuna cewa komai yana cikin tsari. Sannan wani mummunan yanayi ya tashi, alamar zazzabi, ciwon tsoka, ciwon kai, fitsari mai duhu, tashin hankalin barcin ciki, raguwar ci. Likita ya aika don cikakken bincike - gwaje-gwaje na jini, x-ray, ultrasounds da lissafin tomography. Ya bayyana a fili cewa sanadin ba shi da alaƙa da mura ko mura. Kuma matsaloli da hanta an gano. Na daina shan Crestor nan da nan.
Gicciye ya rage cholesterol dina da triglycerides. Amma na lura da karuwa
Gicciye ya rage cholesterol dina da triglycerides. Amma na lura da karuwa a jiki, gajiya, rage karfin jiki. An ji kirji, jin zafi a hannaye, jin zafi a kashin. Likitan zuciya ya yi wani gwaji kuma bai tantance dalilin wannan alamun ba. Na dakatar da shan Krestor, kuma a cikin makonni 2 zuwa 3 nauyi na da lafiya na dawo al'ada. Na kara cin abincin mai na kifi, na fara mai da hankali sosai wajen cin abinci. Ina fatan cewa ba lallai ne ku koma ga daukar hotunan mutum ba.
Ina shan Krestor 10 MG fiye da shekaru 10. Yayi kyakkyawan aiki,
Ina shan Krestor 10 MG fiye da shekaru 10. Ya yi kyakkyawan aiki, ya rage cholesterol na al'ada. Amma, tsawon shekaru na sha wahala daga ciwon haɗin gwiwa, kuma likitoci ba su iya yin bayani ba. Koyaya aboki na labarin cewa haɗin gwiwa na na iya zama sakamakon aikin Krestor. Don bincika zaton sa, na daina shan maganin. Kuma tabbas, kawai bayan 'yan watanni ne zafin haɗin gwiwa ya tsaya. Don haka yanzu ban yarda da Krestor ba.
Ina shan 2.5 MG na Crestor kowace rana (wannan shine rabin 5,5 kwamfutar hannu). Yana da gaske saukar da
Ina shan Crestor 2.5 MG kowace rana (wannan shine rabin 5,5 kwamfutar hannu). Wannan ya rage mini cholesterol daga 248 zuwa 193. Ba abun ban mamaki bane, amma kyakkyawan isasshen magani. Na fara shan tare da 10 MG a kowace rana, amma samun ƙwayar tsoka da haɓaka enzymes hanta.Likita ya ce da ni in gwada sauran sifofi, amma dukkansu suna da sakamako iri daya. Don haka, mun saukar da maganin Crestor har sai an daina jin sakamako masu illa. Yana aiki daidai kuma babu alamun sakamako masu illa yanzu.
Toari ga kasancewa mai ciwon sukari, Ina da babban cholesterol (an bincikar lafiya
Toari ga kasancewa mai ciwon sukari, Na kuma sami babban cholesterol (wanda aka kamu da shi shekaru 12 da suka gabata). Ina kan karancin abinci, kuma har yanzu ba sa cin ƙwai da nama. Amma har yanzu, cholesterol na yayi yawa. Ban so in dauki wani mutum-mutumi ba, saboda na sha wahala daga mummunan tashin hankali lokacin da na dauki lipitor. Amma a bazarar da ta gabata, alamu sun yi muni sosai har Krestor ya sha. Koyaya, na fara da 5 MG sau da yawa a mako. Yanzu, watanni 8 bayan haka, cholesterol dina ya kasance al'ada kuma duk sauran alamu suna cikin kyakkyawan yanayi. My endocrinologist ya yi farin ciki sosai kuma ya ce babu wani dalilin da zai kara kashi zuwa 10 MG. Gaskiya ne, wani lokacin Ina fama da wasu jin zafi a cikin gidajen abinci a cikin wuyan hannu da gwiwoyi, amma wannan ya iya jurewa.
Abun ciki da nau'i na saki
Abubuwan da ke aiki da Krestor shine rosuvastatin. Abun da ya hada magungunan ya hada da abubuwanda zasu taimaka masu: lactose, cellulose, magnesium stearate, phosphate alli. Akwai Crestor a cikin nau'in allunan ruwan hoda, wani zagaye mai zagaye da aka shirya don gudanar da maganin baka. Dangane da bayanin radar, girke-girken Latin yayi kama da wannan: Rp.: Rosuvastatini 0.01 D.t.d.N.10 a tab.obd. S. 1.
Ana amfani da miyagun ƙwayoyi a yawancin sadda:
- Crestor 5 MG
- Crestor 10 MG
- Crestor 20 MG
- Crestor 40 MG.
Ya danganta da sashi, akwai wani zane a gefe ɗaya na kwamfutar hannu. Misali, a wani magani na 10 MG, ya ce "ZD4522 10" akan sa. Allunan an sanya su a cikin bola mai ɗaukar hoto na 7. A cikin kunshin kwali ɗaya za'a iya samun blister 1, 4, 14.
Mafi sau da yawa, ana siyar da kashi 10 na mg - Allunan 98, wato, akwai blister 14 a cikin kunshin. Ganin gaskiyar cewa an ƙera gumakan don amfani na dogon lokaci, da yawa suna ganin yana da fa'ida saya manyan fakitoci lokaci guda.
Ka'idojin aiki
Gicciye wakili ne na rage kiba, wato, rage kiba. Babban tasirinsa yana da niyyar rage yawan ƙwayoyin lipoproteins na ɗimbin yawa a jiki. Penetrating hanta - jikin da ke da alhakin samar da cholesterol, rosuvastatin, abu mai aiki na miyagun ƙwayoyi, yana da tasiri mai tasiri akan samar da tsoffin enzymes.
Koyaya, cholesterol ya shiga cikin jini ba kawai hanta ta samar ba. Angare na wannan abun yana shiga cikin jiki tare da abinci, musamman mai, abinci mai haɗari. Ayyukan maganin yana taimakawa tsaftace tasoshin jini na rashin wadataccen lipoproteins da yawa waɗanda suka riga aka tara. Ana kiran wannan yanayin farkon matakin atherosclerosis.
Idan atherosclerosis ya riga ya fara haɓaka, tasoshin jini da jijiyoyin jini suna tashe tasoshin cholesterol ko plaques, Krestor yana da tasiri a gare su. Tana shiga cikin jiragen ruwa, yana tsabtace masu adon abubuwa. A sakamakon wannan, lumen a cikin tasoshin jijiyoyin jini da jijiyoyin jini suna ƙaruwa, kwararar jini a cikin yankunan da abin ya shafa ya zama al'ada.
Ofaya daga cikin rikicewar ƙwayoyin atherosclerotic shine thrombosis, wanda ke barazanar katse jirgin ruwa ko jijiya. Statins suna hana wannan ta hanyar ƙara yarda a cikinsu ta rage girman filayen.
Krestor ya kasance na mutum-mutumi na ƙarni na huɗu, ana ɗaukar wannan ƙungiyar mafi inganci. Bayan gaskiyar cewa shirye-shiryenta suna taimakawa rage yawan cholesterol a “marasa kyau” a cikin jini, suna kuma haɓaka samar da “mai kyau”. Cholesterol mai kyau "abu ne mai mahimmanci don daidaitaccen aiki na gabobin ciki da yawa, samar da kwayoyin halittu, da karfafa sel membranes da sauran matakai.
Umarnin don amfani
Umarnin don yin amfani da miyagun ƙwayoyi suna kunshe ne a cikin kowane kunshin, yana da mahimmanci ga marassa lafiya suyi hankali da kansu kafin shan kwayoyin. Ana ba da umarnin sashi da tsarin gudanarwa ta hanyar halartar mahaɗan daban daban. Yawancin lokaci ana tsara lokacin kyauta, babban abu shine ɗaukar miyagun ƙwayoyi yau da kullun a lokaci guda.
A cewar masana da yawa, lokacin maraice shine ya fi dacewa da ɗaukar mutum-mutumi, tunda har zuwa ƙarshen ranar adadin ƙwayar cholesterol a cikin jini ya fi na safiya.
An tsara samfurin ne don gudanar da maganin baka, an wanke shi da ruwa kaɗan. Ba kwa buƙatar tauna kwamfutar hannu ba. Kafin kayyade sashi, an wajabta mai haƙuri cikakken bayyani don tantance yanayin tasoshin, ƙididdigar jini, da gabobin tsarin zuciya.
Yawancin lokaci farawa shine 10 MG. Wata daya bayan fara magani, mai haƙuri dole ne ya ɗauki gwajin jini, kuma idan miyagun ƙwayoyi suna da tasiri, babu sakamako masu illa, za a iya ƙara yawan zuwa 20-40 MG kowace rana. Bayan haka, a duk lokacin jiyya, ya zama dole a riƙa yin nazari akai-akai don kimanta sakamakon kuma a daidaita sashi.
Idan an wajabta magunguna don rigakafin cututtuka na tsarin zuciya da jijiyoyin jini, sashi na farko yawanci 5 MG ne. A tsawon lokaci, kamar yadda likitan halartar ya tsara, Hakanan za'a iya karuwa.
Yawanci, an tsara statins don rayuwa, idan ba haka ba, to, tsawon lokacin cin abincin su shine akalla watanni 3-4. Ba za ku iya dakatar da shan kwayoyin ba da sauri, likitocin da ke halartar sun tsara makirci wanda za a rage yawan magunguna na yau da kullun, sannan kawai ana iya dakatar da jiyya.
Contraindications
Duk wani magani a cikin ƙungiyar statin yana da contraindications da yawa don amfani, tunda an dauke su da iko. Ba za a iya amfani da giciye don irin waɗannan alamun ba:
- shekaru zuwa shekaru 18
- ciki da shayarwa,
- mutum rashin jituwa ga rosuvastatin ko duk wani abin da aka haɗa a cikin kayan,
- cututtukan hanta na hanta a lokacin wuce gona da iri,
- ciwon kai.
Ga marasa lafiya da ke cikin haɗarin kamuwa da cutar sankarar mahaifa, sashi na 40 MG kowace rana yana ɗaukar hoto. Yawancin lokaci ana sanya su Crestor 20 MG ko 10 MG farko.
Kuma har da miyagun ƙwayoyi ne contraindicated a cikin marasa lafiya shan wuce kima yawa na giya. Tunda aikin statins an yi shi ne da farko a hanta, idan yana fama da gubobi na giya, ba zai iya tsayar da irin wannan matsa lamba ba. Idan mai haƙuri da ke shan wahala daga shan giya ya daina shan giya, ya yi fama da farfadowa da murmurewa, ana iya ba da magani, amma ya kamata a fara da kaɗan kaɗan.
Side effects
Daga cikin marasa lafiya da ke shan Krestor, tasirin sakamako yawanci yakan faru ne a cikin waɗanda ba su bi shawarar likita ba, fiye da sashi ko ƙin bin ka'idodin contraindications. Matsaloli masu yuwuwar sun hada da:
- matsalar dyspeptik, ciwon ciki,
- ciwon kai, tsananin farin ciki,
- daidaituwa mai daidaituwa
- fata rashes, itching,
- myalgia
- asthenia
- bayyanar puffness.
Abinda yafi Krestor ko Rosuvastatin
Matsakaicin farashin rosuvastatin 20 MG 28 inji mai kwakwalwa. kusan 550 rubles ne, yayin da farashin Crestor ya kusan sau shida. Saboda wannan, yawancin marasa lafiya sun fi son zaɓar zaɓi mai rahusa. Menene bambanci tsakanin kwayoyi, sai dai don irin wannan bambanci a farashin?
Krestor ya kasance na mutum-mutumi na ƙarni na huɗu na ƙarshe, kuma wannan shine babban amfani da miyagun ƙwayoyi. Hanya ce mai kyau, amintacciyar hanya. A cewar likitoci da yawa, idan ka fara ɗaukar mutum-mutumi, kuma zai dauki lokaci mai tsawo, wataƙila don rayuwa, to wannan ya zama asali na asali mai inganci. Wannan magani ne Krestor.
Fa'idodin Crestor, wanda, sabanin abubuwan almararsa da ire-irensa an tabbatar da hukuma, sun haɗa da:
- sakamako mai sauri
- takardar sayen magani mafi qarancin magunguna,
- rage hadarin sakamako masu illa.
Don yanke shawarar abin da ya fi dacewa don ɗauka tare da babban cholesterol, likitan halartar zai taimaka, ganin hoto na gaba ɗaya na yanayin mai haƙuri.
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Na gida Rum bukukuwa
Sinadaran 20 inji mai kwakwalwa. man shanu - 90 g sugar-50 g kwai-manyan manyan koko-3 tbsp. l gari-40 gr vanilla tsantsa-1 h l (ko fakitin vanillin) kimanin 80 ml. ... -
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