Noliprel A: umarnin don amfani

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Noliprel. Yana ba da ra'ayi daga baƙi zuwa shafin - masu amfani da wannan magani, kazalika da ra'ayoyin likitocin kwararru kan amfani da Noliprel a cikin al'adar su. Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Analogs na Noliprel a gaban wadatattun analogues na tsarin ana amfani dasu. Amfani don lura da hauhawar jini da rage karfin jini a cikin manya, yara, harda lokacin daukar ciki da lactation.

Noliprel - haɗuwa mai haɗuwa wanda ya ƙunshi perindopril (mai hana ACE) da indapamide (mai kamuwa da thiazide). Tasirin magungunan magungunan yana faruwa ne sakamakon haɗuwa da kayan aikin kowane ɗayan abubuwan haɗin. Haɗin amfani da perindopril da indapamide yana samar da daidaituwa na sakamako na antihypertensive idan aka kwatanta da kowane ɗayan abubuwan daban.

Magungunan yana da tasiri mai amfani da kwayar cutar antihypertensive mai tasiri akan duka systolic da bugun jini na jini a cikin supine da matsayin tsaye. Tasirin miyagun ƙwayoyi ya ɗauki tsawon awanni 24. Rage sakamako na asibiti yana faruwa ƙasa da wata 1 bayan farawar magani kuma baya tare da tachycardia. Rashin magancewa baya tare da haɓaka ciwo na cirewa.

Noliprel yana rage matakin hauhawar jini a ventricular hagu, yana inganta jijiyoyin jijiya, yana rage OPSS, baya tasiri metabolism (jimlar jimlar, HDL-C, HDL-C, triglycerides).

Perindopril shine mai hana enzyme wanda ke canza angiotensin 1 zuwa angiotensin 2. Wani angiotensin mai juya enzyme (ACE), ko kinase, shine exopeptidase wanda ke aiwatar da juyawa na angiotensin 1 zuwa angiotensin 2, wanda ke da tasirin vasoconstrictor, da lalata lalata jiragen ruwa da ba shi da tasiri a jini . Sakamakon haka, perindopril yana rage ɓoyewar aldosterone, bisa ga ka'idodin amsawar mara kyau, yana ƙaruwa da aiki na renin a cikin jini, tare da tsawaita shi yana rage OPSS, wanda galibi saboda tasirin tasirin jijiyoyin jini a cikin tsokoki da kodan. Wadannan tasirin ba su da jinkiri a cikin salts da ruwa ko haɓakar reflex tachycardia tare da tsawaita amfani.

Perindopril yana da tasiri na antihypertensive a cikin marasa lafiya tare da ƙananan low da al'ada aiki renin aiki.

Tare da yin amfani da perindopril, akwai raguwa a duka systolic da tashin jini na jini a cikin supine da matsayin tsaye. Rashin maganin ba ya kara karfin jini.

Perindopril yana da tasirin vasodilating, yana taimakawa wajen dawo da haɓaka manyan jijiyoyin jini da kuma tsarin bangon jijiyoyin kananan jijiyoyi, sannan kuma yana rage haɓakar ventricular hagu.

Perindopril yana daidaita aikin zuciya, rage haɓakawa da saukarwa.

Haɗewar amfani da thiazide diuretics yana haɓaka sakamako na antihypertensive. Bugu da ƙari, haɗuwa da inhibitor na ACE da turezide diuretic suma suna rage haɗarin hypokalemia tare da diuretics.

A cikin marasa lafiya da rauni na zuciya, perindopril yana haifar da raguwa a cike matsin lamba a cikin dama da hagu ventricle, raguwa a cikin zuciya, haɓaka fitowar zuciya da haɓakawa a cikin jigon bugun zuciya, da kuma karuwa a cikin jini na yanki a cikin tsokoki.

Indapamide asalinsa ne na sulfanilamide, mai kama da shi a cikin kayan magungunan magungunan zuwa maganin thiazide diuretics. Yana hana sake farfado da sinadarin sodium ion a cikin cortical bangare na Henle madauki, wanda ke haifar da karuwar urinary excretion na sodium, chlorine kuma, a cikin mafi ƙarancin adadin, potassium da ion magnesium, don haka yana ƙaruwa diuresis. An bayyana tasirin antihypertensive a allurai wanda galibi basa haifar da sakamako na diuretic.

Indapamide yana rage yawan jijiyoyin bugun jini dangane da adrenaline.

Indapamide ba ya shafar lipids na plasma (triglycerides, cholesterol, LDL da HDL), metabolism metabolism (ciki har da marasa lafiya tare da mellitus na sukari concomitant).

Indapamide yana taimakawa rage ragewar hauhawar jini.

Abun ciki

Perindopril arginine + Indapamide + magabata.

Pharmacokinetics

Abubuwan da aka kera na pharmacokinetic na perindopril da indapamide a hade ba su canzawa idan aka kwatanta da amfaninsu na daban.

Bayan sarrafawar bakin, perindopril yana cikin hanzari. Kusan 20% na jimlar adadin perindopril da aka zartar an canza su zuwa aiki na metabolindo na perindoprilat. Lokacin shan magani tare da abinci, jujjuyawar perindopril zuwa perindoprilat yana raguwa (wannan tasirin bashi da ƙimar asibiti). Perindoprilat an cire shi a cikin fitsari. T1 / 2 na perindoprilat shine sa'o'i 3-5. Ragewa da perindoprilat yana raguwa a cikin tsofaffi marasa lafiya, da kuma a cikin marasa lafiya da gazawar renal da rashin zuciya.

Indapamide yana hanzari kuma yana ɗauke shi gaba ɗaya daga narkewa. Maimaita tsarin magani ba ya haifar da tarawa a cikin jiki. An keɓe shi da fari tare da fitsari (70% na maganin da aka gudanar) kuma tare da feces (22%) a cikin nau'i na metabolites marasa aiki.

Alamu

• mahimmancin hauhawar jini.

Sakin Fom

Allunan 2.5 MG (Noliprel A).

Allunan kwayoyi 5 MG (Noliprel A Forte).

Allunan 10 MG (Noliprel A Bi-Forte).

Umarnin don amfani da sashi

Sanya cikin, zai fi dacewa da safe, kafin abinci, kwamfutar hannu 1 lokaci 1 kowace rana. Idan bayan wata 1 bayan fara maganin da ba'a san tasirin sakamako ba, to ana iya kara kashi zuwa kashi 5 MG (kamfanin da ke sana’ar karkashin sunan kasuwanci Noliprel A forte).

Ya kamata tsofaffi marasa lafiya su fara farawa tare da kwamfutar hannu 1 sau 1 a rana.

Bai kamata a rubuta Noliprel ga yara da matasa ba saboda karancin bayanai akan inganci da amincin marasa lafiya a wannan rukunin na wannan zamani.

Side sakamako

• bushe bakin
• tashin zuciya
• rage cin abinci
• ciwon ciki
• dandano cuta
• maƙarƙashiya
• bushe tari, dagewa na dogon lokaci yayin shan magunguna na wannan rukunin kuma ya ɓace bayan janyewar su,
• orthostatic hypotension,
• basur,
• fata rashes,
• wuce haddi na tsarin lupus erythematosus,
• angioedema (edema ce ta Quincke),
• halayenka
• paresthesia
• ciwon kai
• asthenia
• tashin hankali na bacci
• rashin karfin jiki
• tsananin farin ciki
• jijiyar wuya
• thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia,
• hypokalemia (musamman mahimmanci ga marasa lafiya a hadarin), hyponatremia, hypovolemia, wanda ke haifar da bushewa da hauhawar jini na orthostatic, hypercalcemia.

Contraindications

• tarihin cutar anjedeede (tare da sauran masu hana ACE),
• maganin gado / idiopathic angioedema,
• tsananin gazawar koda (CC

Aikin magunguna

NOLIPREL A haɗuwa ne da abubuwa guda biyu masu aiki, perindopril da indapamide. Wannan magani ne na kanjamau, ana amfani dashi don kula da hawan jini (hauhawar jini).

Perindopril yana cikin rukuni na kwayoyi da ake kira ACE inhibitors. Yana aiki ta hanyar himmatuwa da haɓaka tasirin jijiyoyin jini, wanda yake sauƙaƙe allurar jini. Indapamide mai diuretic ne. Diuretics yana kara yawan fitsari wanda kodan ke haifarwa. Koyaya, indapamide ya bambanta da sauran cututtukan diuretics, saboda kawai dan ƙara ƙarin yawan fitsari ne yake samarwa. Kowane ɗayan sinadaran masu aiki suna rage karfin jini kuma tare suke sarrafa hawan jini.

Contraindications

• idan a da, lokacin shan wasu masu hana ACE ko a wasu yanayi, kai ko ɗaya daga danginku kun nuna alamun cututtuka kamar hawaye, kumburi na fuska ko harshe, matsanancin zafi, ko fitsari na fata (angiotherapy),

• Idan kuna da cutar hanta mai nauyi ko hepatic encephalopathy (cututtukan kwakwalwa na narkewa),

• idan ka sami rauni sosai game da aiki na koda ko kuma kana fuskantar dialysis,

• Idan matakin potassium dinku ya yi ƙasa ko ya yi yawa,

If Idan kuna zargin rashin karfin zubar da ciki a cikin zuciya (tsayar da gishiri, tsananin numfashi),

• idan kana da ciki ko kana shirin daukar ciki,

• idan kana shayarwa.

Haihuwa da lactation

Kada ku ɗauki NOLIPRELA a farkon watanni uku na ciki kuma kar ku ɗauka daga farkon watan 4 na ciki (duba Contraindications). Idan an shirya juna biyu ko an tabbatar da gaskiyar daukar ciki, to ya kamata ku canza zuwa wani nau'in magani da wuri-wuri.

Kada ku dauki NOLIPREL A idan kunyi ciki.

Yi magana da likitanka nan da nan.

Sashi da gudanarwa

Idan kun ɗauki NOLIPREL A fiye da wanda aka ba ku shawarar:

Idan kun sha kwayoyi da yawa, tuntuɓar dakin gaggawa na gaggawa ko gaya wa likitanka nan da nan. Mafi tasirin sakamako idan aka samu yawan shan ruwa shine raguwar hauhawar jini. Idan hauhawar jininka ta sauka (alamomi kamar suma ko suma), kwanta da ɗaga kafafunku, wannan na iya saukaka yanayinku.

Idan kun manta ku ɗauki NOLIPRELA

Yana da mahimmanci a sha maganin a kowace rana, tunda tsari na yau da kullun yana sa magani ya zama mafi inganci. Koyaya, idan kun manta shan kwafin NOLIPREL A, ɗauki kashi na gaba a lokacin da aka saba. Kar a ninka sau biyu mai zuwa.

Idan ka daina shan NOLIPRELAA

Tunda maganin rigakafin ƙwayar cuta yana ɗaukar tsawon rayuwa, ya kamata ka nemi likitanka kafin ka dakatar da maganin.

Idan kuna da ƙarin tambayoyi game da shan maganin, tuntuɓi likitan ku ko likitan magunguna.

Side sakamako

Wadannan sun hada da:

• na kowa (ƙasa da 1 cikin 10, amma fiye da 1 cikin 100), raunin narkewa (jin zafi a ciki ko ciki, asarar ci, tashin zuciya, maƙarƙashiya, canjin ɗanɗano), bushe baki, bushe tari.

• ba na kowa ba (kasa da 1 cikin 100, amma sama da 1 a cikin 1000): jin gajiya, tsananin damuwa, ciwon kai, sauyawa yanayi, tashin hankalin bacci, damuna, abubuwan shakatawa, rashin lafiyan jiki kamar fatar fata, purpura (jan baki a jikin fata), hypotension (saukar karfin jini), orthostatic (jin haushi a kan tashi) ko a'a. Idan kun sha wahala daga tsarin lupus erythematosus (wani nau'in cutar kumburi-kumburin ƙwayar cuta), to lalacewa mai yiwuwa ne

• da wuya sosai (ƙasa da 1 cikin 10,000): cutuka (alamomi kamar hawaye, kumburi na fuska ko harshe, matsanancin zafi ko fatar fata), ƙarin haɗarin rashin ruwa a cikin tsofaffi da kuma marasa lafiya da gazawar zuciya. Game da gazawar hanta (cutar hanta), farawar encephalopathy na hanta (cututtukan ƙwaƙwalwa mai narkewa) mai yiwuwa ne. Rashin lalacewa a cikin jini, kodan, hanta, pancreas, ko canje-canje a cikin ma'aunin dakin gwaje-gwaje (gwaje-gwajen jini) na iya faruwa. Likitanka na iya yin gwajin gwajin jini don duba lafiyar ka.

Dakatar da shan wannan magani nan da nan kuma tuntuɓi likitan ku idan kuna da ɗayan waɗannan yanayi: fuskarku, leɓunku, bakinku, harshe ko makogwaro sun kumbura, kuna da wahalar numfashi, kuna jin ƙaiƙayi ko kuka rasa hankali, ku bugun bugun zuciya mara nauyi ko maras tabbas.

Idan tasirin sakamako ya zama mai mahimmanci ko kuma idan kun lura da tasirin da ba'a so ba wanda aka jera shi a cikin wannan takarda, gaya wa likitan ku ko mai harhaɗa magunguna.

Yin hulɗa tare da wasu kwayoyi

Guji yin amfani da NOLIPREL A tare da magungunan masu zuwa:

• Lithium (wanda aka yi amfani da shi don magance bacin rai),

• diuretics na potassium-sparing (spironolactone, triamteren), salts na potassium.

Jiyya tare da NOLIPRELOM A na iya shafar amfani da wasu magunguna.

Tabbatar sanar da likitanka idan kuna shan magungunan masu zuwa, saboda ya kamata ku mai da hankali musamman lokacin shan su:

• magungunan da ake amfani da su wajen maganin hauhawar jini,

• procainamide (don lura da cututtukan zuciya marasa daidaituwa),

• allopurinol (don maganin gout),

• terfenadine ko astemizole (antihistamines don magance zazzabin hay ko rashin lafiyan),

• corticosteroids, waɗanda ake amfani da su don magance yanayi daban-daban, gami da asma mai zafi da amosanin gabbai,

• rigakafi na rigakafi waɗanda aka yi amfani da su don magance cututtukan autoimmune ko bayan tiyata don hana ƙi (misali, cyclosporin),

• magunguna da aka wajabta don maganin cutar kansa,

• erythromycin a cikin ƙwayar cuta (ƙwayoyin cuta),

• halofantrine (ana amfani da shi don magance wasu nau'in malaria),

• pentamidine (wanda aka yi amfani da shi don magance cututtukan huhu),

• vincamine (an yi amfani da shi don maganin cututtukan ƙwaƙwalwar ƙwaƙwalwa a cikin tsofaffi marasa lafiya),

• bepridil (wanda aka yi amfani da shi don magance angina pectoris),

• sultopride (magani mai hana haihuwa),

• magungunan da aka tsara a cikin lura da rikicewar bugun zuciya (alal misali, quinidine, hydroquinidine, melopyramide, amiodarone, sotalol),

• digoxin (don maganin cututtukan zuciya),

• baclofen (don lura da taurin tsoka, wanda ke faruwa a wasu cututtuka, alal misali, tare da cututtukan fata),

• magunguna masu ciwon sukari, irin su insulin ko metformin,

• abubuwan motsa jiki masu karfafa jiki (misali, senna),

• magungunan anti-mai kumburi marasa guba (alal misali, ibuprofen) ko magungunan salicylates masu yawa (alal misali asfirin),

• amphotericin B a cikin jijiya (don lura da mummunan cututtukan fungal),

• magunguna don maganin cututtukan kwakwalwa, kamar baƙin ciki, damuwa, schizophrenia, da dai sauransu (alal misali, cututtukan cututtukan cututtukan cyclic guda uku, maganin ƙwayoyin cuta),

• tetracosactide (don magance cutar ta Crohn).

Siffofin aikace-aikace

Shan NOLIPREL A da abinci da abin sha

Zai fi kyau a ɗauki NOLIPREL A kafin abinci.

Motar motoci da injin sarrafa abubuwa: NOLIPREL A ba ya shafar bacci, amma a wasu marassa lafiya, saboda karancin jini, maganganu iri-iri na iya bayyana, alal misali, farin ciki ko rauni. Sakamakon haka, ikon iya tuƙa mota ko wasu injuna na iya zama da matsala.

Bayani mai mahimmanci akan wasu kayan masarufi a cikin NOLIPREL A

NOLIPREL A ya ƙunshi lactose, idan likita ya gaya muku cewa ba ku haƙuri da wasu nau'o'in sukari, to sai ku nemi likitanku kafin fara wannan magani.

Kariya da aminci

• Idan kun sha wahala daga jijiyoyin jijiyoyi (tokace babban tasirin jini da ke fitowa daga zuciya), cututtukan zuciya da jijiyoyin jini (cututtukan zuciya da jijiyoyin jiki) ko kuma hanjin jini na koda

• idan kun sha wahala daga wata cuta ko cutar koda,

• idan kun sha wahala daga aikin hanta mai rauni,

• Idan kun sha wahala daga cututtukan jijiyoyin bugun jini kamar na lupus erythematosus ko scleroderma,

• Idan kun sha wahala daga atherosclerosis (hardenden bango na arteries),

• Idan kun sha wahala daga cututtukan hawan jini (cututtukan cututtukan ƙwayar cuta na parathyroid gland),

Idan ka sha wahala daga gout,

• idan kana da ciwon sukari,

• idan kun kasance akan abinci mai gishiri kaɗan ko kun ɗauki madadin gishiri da ke kunshe da potassium,

• Idan kuna shan lithium ko potassium-spure diuretics (spironolactone, triamteren), saboda bai kamata ku sha su ba lokaci guda tare da NOLIPREL A (duba. Shan wasu kwayoyi).

Lokacin da kake shan NOLIPREL A, ya kamata kuma sanar da mai kula da lafiya ko ma'aikatan lafiya game da waɗannan masu zuwa:

• idan kuna da maganin kashe zafin jiki ko babban tiyata,

• idan kun jima da cutar gudawa ko amai,

• Idan kun sha wahala na LDL (cire kayan aiki na cholesterol daga jini),

• Idan kun sha wahala na rashin damuwa, wanda zai rage rashin lafiyan halayen kudan zuma ko gandun dajin danshi,

• idan ana gudanar da gwajin lafiya, wanda ke buƙatar gabatarwar wani abu mai kunshe-kundi na aidin (abu ne wanda ya bada damar bincika gabobin ciki, kamar kodan ko ciki, ta yin amfani da x-ray).

'Yan wasan motsa jiki ya kamata su san cewa NOLIPREL A ya ƙunshi abu mai aiki (indapamide), wanda zai iya ba da kyakkyawar amsawa yayin gudanar da sarrafa doping.

NOLIPREL A bai kamata a rubuta wa yara ba.

Formaddamar da tsari da abun da ke ciki

Ana samar da miyagun ƙwayoyi a cikin nau'ikan allunan da aka rufe fim: oblong, fararen fata, tare da haɗari a garesu (14 ko 30 kowane a cikin kwalban polypropylene sanye take da mai jigilar kayan wuta da marubuci dauke da gel mai ɗumi, a cikin kwali na kwali tare da sarrafawa na farko na buɗe 1 kwalban a kowace Pcs 14,, kwalabe 1 ko 3 na guda 30,, Ga asibitoci - a cikin kwali na kwali na kwalabe 30, a cikin kwali mai kwali tare da iko na farko na 1 pallet da umarnin don amfani da Noliprel A).

Kwamfutar hannu 1 ya ƙunshi:

• kayan aikin aiki: perindopril arginine - 2.5 MG (ya dace da abun da ke cikin perindopril a cikin adadin 1.6975 mg), indapamide - 0.625 mg,
• ƙarin abubuwa: lactose monohydrate, silicon dioxide na anhydrous, silsilar dioxide, sodium carboxymethyl sitaci (nau'in A), maltodextrin, magnesium stearate,
• shafi fim: premix don rufin SEPIFILM 37781 RBC glycerol, macrogol 6000, hypromellose, titanium dioxide (E171), magnesium stearate, macrogol 6000.

Pharmacodynamics

Noliprel A wani shiri ne wanda aka haɗe wanda kayan aikinsu sune sifofin angiotensin wanda ke canza enzyme (ACE) mai hanawa da kuma diuretic, wanda shine ɓangare na ƙungiyar sulfonamide. Noliprel A yana da kaddarorin magunguna saboda ingancin magunguna na kowane ɗayan kayan aikinsa, daidai gwargwado.

Perindopril shine mai hana ACE (kinase II). Wannan enzyme yana nufin exopeptidases wanda ke canza angiotensin I cikin abu mai vasoconstrictor, angiotensin II, da lalata lalata pepide bradykinin wanda ke rikitar da jijiyoyin jini zuwa aikin heptapeptide mai aiki.

Sakamakon perindopril shine:

• rage narkewar aldosterone,
• increasedara yawan aikin renin plasma bisa ga ka'idar mummunan ra'ayi,
• raguwa a cikin duka jijiyoyin bugun jini na jijiyoyin jiki (OPSS), tare da tsawan amfani, yana hade da aiki tare da matakan jini a cikin tsokoki da kodan.

Wadannan tasirin ba sa haifar da gishiri da riƙewar ruwa ko haɓakar reflex tachycardia. Perindopril yana nuna sakamako mai rauni duka a ƙarami da al'ada aiki renin plasma. Hakanan yana bayar da gudummawa ga daidaituwar ƙwayar zuciya, rage haɓakawa da bayan saiti. A cikin marasa lafiya da rauni na zuciya (CHF), yana ba da gudummawa ga raguwa a cikin OPSS, raguwa a cike matsin lamba a cikin hagu da dama ventricles na zuciya, karuwa a cikin aikin zuciya, da kuma karuwa a cikin jijiyoyin jini na jini.

Indapamide - diuretic na rukunin sulfonamides, yana da kaddarorin magunguna masu kama da na magungunan thiazide. Sakamakon dakatar da sake dawo da sinadarin sodium ion a cikin cortical bangare na Henle madauki, kayan yana taimakawa wajen kara fitar da sinadarin chlorine, sinadarin sodium, da kuma karancin sinadarin magnesium da potassium ta hanyar kodan, hakan yana haifar da karuwar fitowar fitsari da kuma raguwar hauhawar jini (BP).

Noliprel A ana nuna shi ta hanyar bayyanar da tasirin da ya dace da ƙarfin jiki na tsawon awanni 24 akan karfin jini da na systolic a cikin matsayin tsaye da matsayin supine. An samu daidaitaccen raguwar hauhawar jini a cikin ƙasa da wata daya bayan fara magani kuma baya tare da bayyanar tachycardia. Rashin shan maganin ba ya haifar da cututtukan cirewa.

Noliprel A yana samar da raguwa a cikin digiri na hauhawar jini ventricular hagu (GTL), haɓakawa a cikin ƙwayar jijiya, raguwa a cikin OPSS, ba shi da tasiri a kan ƙwayar tsoka na triglycerides, jimlar cholesterol, ƙarancin lipoprotein mai yawa (LDL) da kuma babban (HDL) cholesterol mai yawa.

Sakamakon amfani da haɓakar perindopril da indapamide akan GTL an kafa su idan aka kwatanta da enalapril. A cikin marasa lafiya da GTL da hauhawar jijiya, shan 2 mg perindopril erbumin (daidai yake da perindopril arginine a wani kashi na 2.5 mg) / indapamide 0.625 mg ko enalapril 10 MG 1 a rana, tare da karuwa a cikin kashi na perindopril erbumin zuwa 8 MG (daidai yake da perindopril arginine har zuwa 10 MG) / indapamide har zuwa 2.5 MG ko enalapril har zuwa 40 MG sau ɗaya a rana; a cikin rukuni na perindopril / indapamide, an ƙara raguwa da yawa a cikin ƙasan ventricular mass index (LVMI) idan aka kwatanta da ƙungiyar enalapril. An lura da mafi mahimmancin tasiri akan LVMI yayin kulawa tare da perindopril tare da erbumin 8 mg / indapamide 2.5 mg.

An kuma lura da ƙarin tasirin antihypertensive a cikin haɗin haɗin gwiwa tare da perindopril da indapamide idan aka kwatanta da enalapril.

A cikin marasa lafiya da nau'in ciwon sukari na 2 na mellitus, alamu na matsakaici: hawan jini - 145/81 mm RT. Art., Ƙididdigar jiki (BMI) - 28 kg / m he, glycosylated haemoglobin (HbA1c) - 7.5%, shekaru - shekaru 66 sunyi nazarin tasirin akan babban micro- da rikitarwa na macrovascular yayin farwa tare da tsayayyen haɗuwa na perindopril / indapamide azaman adjunct zuwa daidaitaccen tsarin kulawa na glycemic, da kuma dabarun sarrafa glycemic m (IHC) (manufa HbA1c

Pharmacokinetics da kuma kantin magunguna

Magungunan magungunan perindopril da indapamide lokacin da aka yi amfani dasu a hade daidai suke da lokacin da aka yi amfani da su daban. Bayan maganin baka, perindopril yana talla da sauri. Matsayin bioavailability shine 65-70%. Kimanin 20% na jimlar perindopril daga baya an canza zuwa perindoprilat (metabolite mai aiki). Ana lura da mafi girman yawan abubuwan haɗuwa a cikin plasma bayan sa'o'i 3-4. Kasa da kashi 30% yana ɗaukar garkuwar jini, gwargwadon maida hankali ne ga jini. Rabin rayuwar shine awoyi 25. Ta hanyar shinge na jini, abu ya shiga. Perindoprilat an cire shi daga jiki ta cikin kodan. Rabin rayuwar shi 3-5 awanni. Akwai jinkirin gudanar da aikin perindoprilat a cikin tsofaffi, haka kuma a cikin marasa lafiya da raunin zuciya da gazawar koda.

Indapamide gaba daya kuma in mun gwada da sauri daga narkewa. Matsakaicin yawan abu a cikin plasma ana lura dashi sa'a daya bayan gudanarwar baka.

Tare da kariyar plasma, abu yana ɗaukar nauyin 79%. Cire rabin rayuwar shine awanni 19. Abubuwan da aka keɓe sun kasance a cikin nau'ikan metabolites marasa aiki ta hanyar kodan (kusan 70%) da hanji (kusan 22%). A cikin mutane tare da gazawar koda, ba a lura da canje-canje a cikin kantin magunguna na kayan ba.

Alamu don amfani da Noliprel

An lura da alamun amfani da miyagun ƙwayoyi:

• da muhimmancihauhawar jini,
• buƙatar rage haɗarin rikicewar microvascular a cikin mutane tare da koda, na jijiyoyin bugun gini, da cututtukan zuciya waɗanda ke famahauhawar jinikazalika ciwon sukari na biyu.

Side effects

• A cikin ayyukan tsarin zuciya: tashin hankali mai zurfi, rushewar orthostatic, a cikin mafi yawan lokuta: arrhythmia, bugun jini, infarction na zuciya.
• A cikin ayyukan tsarin tsinkaye: lalacewar aikin na koda, proteinuria a cikin mutane tare da glomerular nephropathy, a cikin mafi yawan lokuta, m renal gazawar. Za'a iya rage karfin aiki.
• A cikin ayyuka na tsakiya da na gefe NS: gajiya, tsananin farin ciki, ciwon kai, asthenia, yanayin rashin kwanciyar hankali, karancin ji, hangen nesa, raguwar ci, damisa, a wasu yanayi - wawa.
• A cikin ayyukan tsarin numfashi: tari, wahala numfashi, bronchospasm, fitar hanci.
• A cikin ayyukan narkewar hanji: alamomin dyspeptik, ciwon ciki, maganin ciwon huhu, cholestasis, ƙara yawan aiki na transaminases, hyperbilirubinemia.
• A cikin ayyukan tsarin jini: a bango na hemodialysis ko bayan sakewar koda, marasa lafiya na iya haɓaka da ƙarancin rashin lafiya, a lokuta da dama, thrombocytopenia, pancytopenia, agranulocytosis, hemolytic anemia.
• Bayyanar bayyanar cututtuka: itch fata, fitsari, edema, urticaria.
• Marasa lafiya da rashin wadataccen hepatic na iya haɓaka encephalopathy hepatic. A cikin mutane da damuwa damuwa-ruwa electrolyte, hyponatremia, hypovolemia, hypokalemia, rashin ruwa na iya faruwa.

Umarnin don amfani da Noliprel (hanya da sashi)

Ana amfani da allunan Noliprel da safe. An wajabta magunguna ɗaya a kowace rana. Umarnin don Noliprel Forte yana ba da irin tsarin kula da jiyya. Noliprel A da Noliprel A Bi Forte an wajabta su ga marasa lafiya a kwamfutar hannu 1 a kowace rana. Idan a cikin marasa lafiya keɓantaccen ɗaukar hoto daidai yake da ko mafi girma daga 30 ml / min, to babu buƙatar rage kashi. Idan sharewar yayi daidai ko ya wuce miliyan 60 a kowace rana, to a lokacin magani ya zama dole a sanya ido sosai a kan sinadarin potassium da creatinine a cikin jini.

Idan ya cancanta, bayan watanni da yawa na magani, likita zai iya ƙara yawan ƙwayar ta hanyar rubuta Noliprel A Forte ko wani nau'in wannan magani maimakon Noliprel.

Yawan abin sama da ya kamata

Tare da yawan ƙwayar maganin ƙwayar cuta, akwai raguwa mai ƙarfi a cikin matsin lamba, tashin zuciya, amai,tsananin farin ciki, tashin hankali na yanayi, alamun rashin nasara na koda, rashin daidaituwa na lantarki. A wannan yanayin, ya zama dole don daidaita ma'aunin ruwa-electrolyte zuwa al'ada, kurkura ciki, ɗauka enterosorbents. Ana iya cire metabolites na Noliprel ta amfani da dialysis. Idan ya cancanta, ana sarrafa ruwan daskararre.

Zabi ne

A liyafar Noliprela Ana buƙatar wadataccen ɗaga jiki a jiki, tunda haɓakar ciwon sikari mai yiwuwa ne.
Ana gudanar da miyagun ƙwayoyi a ƙarƙashin kulawa da ƙwayoyin lantarki, creatinine da hawan jini.
Tare da rikicewar bugun zuciya za a iya haɗe shi da beta-blockers.
Shan nonon yana ba da sakamako mai kyau yayin gudanar da gwaje-gwaje na gwaje-gwaje don doping.
Yakamata a yi taka tsantsan lokacin tuki ko aiki da ingantattun hanyoyin, musamman a farkon makonnin shiga.

Umarni na musamman

Mutanen da aka wajabta musu magani tare da Noliprel suna buƙatar isasshen bushewar jiki don hana raguwa matsananciyar ƙarfi.

Ana iya kula da mutanen da ke da rauni na zuciya tare da beta-blockers a lokaci guda.

Lokacin yin jiyya tare da Noliprel, an lura da ingantaccen sakamako yayin gwajin doping.

A cikin makonni na farko na jiyya, yana da mahimmanci a tuƙa motoci a hankali ko kuma a yi aiki da ingantattun hanyoyin yayin jiyya tare da Noliprel.

Idan an lura da raguwa sosai a matsin lamba yayin jiyya, ana buƙatar gudanar da 0.9% sodium chloride a cikin jijiya.

Kulawa da marasa lafiya tare da gazawar jini a cikin kwakwalwa ko tare da cututtukan zuciya da jijiyoyin jini kuna buƙatar fara da ƙananan allurai na Noliprel.

A cikin mutanen da ke da babban uric acid a cikin jini, haɗarin haɓaka haɗarin haɓakar haɓakar Noliprel shine gout.

Analogs na Noliprel

Analogs na Noliprel, da kwayoyi Noliprel A Be Forte, Noliprel A Forte wasu magunguna ne waɗanda ake amfani da su don rage karfin jini da kuma dauke da abubuwa masu aiki iri ɗaya, watau, perindopril da indapamide. Wadannan kwayoyi magunguna ne Co-prenesa, Prestarium Farashi na analogues na iya zama ƙasa da farashin Noliprel da ire-iren sa.

Ba a wajabta magunguna don kula da yara masu shekaru 18 ba, tunda babu takamaiman bayanai game da inganci da amincin irin wannan magani.

Yayin ciki da lactation

Mata masu juna biyu da uwaye yayin ciyarwa Yin amfani da Noliprel a cikin madara mai nono ne. Tsarin kulawa da wadannan magunguna na iya haifar da ci gaban cuta da cututtuka a cikin tayin, haka kuma yana haifar da mutuwar tayi. Idan mace ta gano game da juna biyu a lokacin jiyya, babu buƙatar katse ciki, amma mai haƙuri ya kamata sane da yiwuwar sakamakon. Yayin taron haɓakar hawan jini, an wajabta wani magani na rigakafi. Idan mace ta dauki wannan magani a cikin watanni na biyu da na uku, to ya kamata a yi duban dan tayi don tantance yanayin kwanyarsa da koda.

Jariri wanda iyayensu suka sha magungunan na iya wahala daga bayyanar cututtukan jijiyoyin jini, don haka suna bukatar tabbatar da kulawa ta kwararru.

A lokacin da shayar da nono, da miyagun ƙwayoyi ne contraindicated, sabili da haka, lactation a lokacin far ya kamata a tsaya ko wani magani ya kamata a zabi.

Ra'ayoyi game da Noliprel

Yin bita a kan tattaunawar game da Noliprel, har ma game da magunguna Noliprel A, Noliprel A Fort, Noliprel A Bi Forte suna nuna cewa wannan magani yana rage karfin jini. Magungunan suna kula da karfin jini na yau da kullun, yana rage yiwuwar haɓaka bugun jini da rarrabuwa na zuciya.

Binciken akan Noliprel Forte kuma sau da yawa yana dauke da bayanin cewa wannan maganin da sauran nau'ikanta suna ba da sakamako mai kyau a lokuta idan wasu magunguna basu da tasiri. Wani lokaci marasa lafiya suna lura da ci gaban wasu sakamako masu illa, musamman, bushe tari, ciwon kai, amma ba su da ƙarfi sosai.

Hakanan likitocin suna lura da tasirin magungunan, amma koyaushe lura cewa yakamata a sha maganin sosai bisa ga umarnin kuma yin la'akari da shawarar kwararrun. Musamman, ya kamata a sha miyagun ƙwayoyi a kai a kai, kuma ba kawai lokacin tsananin tsalle-tsalle a cikin karfin jini ba.

Farashin Noliprel, inda zaka siya

Farashin Noliprel shine matsakaici na 500 rubles a kowane fakiti guda 30. Farashin a Moscow don Noliprel A yana daga 500 zuwa 550 rubles. Farashin Noliprel Forte daga 550 rubles kowace kunshin. Ana iya siyan Noliprel A Forte 5 MG akan farashin 650 rubles. Kudin Noliprel A Bi Forte daga 700 rubles ne. a kowace fakiti guda 30.