Liptonorm: umarnin don amfani, analogues, farashi, sake dubawa

Lambar yin rijista: P A'a 016155/01

Sunan kasuwanci na miyagun ƙwayoyi: Liptonorm®

Sunan kasa da kasa mai zaman kanta: Atorvastatin

Form sashi: allunan mai kauri

Abun ciki

Kowane kwamfutar hannu mai rufi ya ƙunshi:
Abu mai aiki - alli na Atorvastatin, a cikin adadin wanda yake daidai da 10 mg da 20 mg na atorvastatin
Fitowa: carbonate carbonate, microcrystalline cellulose, lactose, tween 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium dioxide, polyethylene glycol.

Bayanin

Farar fata, zagaye, allunan da aka sanya fim din biconvex. A hutu, allunan fararen fata ne ko kuma fararen fata.

Rukunin Magunguna: wakili mai saurin rage farin jini - mai hanawa na HMG CoA reductase.

ATX CODE S10AA05

Kayan magunguna

Pharmacodynamics
HypolipPs wakili daga rukuni na statins. Babban aikin aiwatar da atorvastatin shine hana ayyukan 3-hydroxy-3-methylglutaryl coenzyme A - (HMG-CoA) reductase, enzyme wanda ke daukar nauyin juyawa na HMG-CoA zuwa mevalonic acid. Wannan canjin shine ɗayan matakan farko a cikin sarkar haɗin cholesterol a cikin jiki. Cutar da sinadarai na atorvastatin cholesterol yana haifar da karuwa da masu karɓar LDL (ƙananan ƙarancin lipoproteins) a cikin hanta, da kuma a cikin ƙwayoyin cuta na extrahepatic. Waɗannan masu karɓa suna ɗaukar barbashi na LDL kuma suna cire su daga jini, wanda ke haifar da ƙananan ƙwayoyin LDL a cikin jini.
Tasirin antisclerotic na atorvastatin sakamako ne sakamakon tasirin magani a jikin bangon jijiyoyin jini da abubuwan jini. Magungunan yana hana kwayar halitta mai suna isoprenoids, waɗanda sune abubuwan haɓaka abubuwan haɓaka ƙwayoyin sel na ciki na jijiyoyin jini. A ƙarƙashin tasirin atorvastatin, haɓaka haɓakar endothelium na tasoshin jini yana inganta. Atorvastatin lowers cholesterol, low lipoproteins mai yawa, apolipoprotein B, triglycerides. Sanadin karuwa a cikin HDL cholesterol (babban yawa dipoproteins) da apolipoprotein A.
Ayyukan miyagun ƙwayoyi, a matsayin mai mulkin, yana haɓaka bayan makonni 2 na gudanarwa, kuma ana samun mafi girman sakamako bayan makonni huɗu.

Pharmacokinetics
Nuna rashin hankali yana da girma. Lokacin da ya isa zuwa mafi yawan maida hankali shine 1-2 sa'o'i, matsakaicin maida hankali a cikin mata shine 20% mafi girma, AUC (yanki a ƙarƙashin juji) yana 10% ƙananan, matsakaicin maida hankali a cikin marasa lafiya tare da guguwar giya shine sau 16, AUC ya ninka sau 11 fiye da na al'ada. Abincin dan kadan yana rage gudu da tsawon lokacin shan ƙwayoyi (ta 25% da 9%, bi da bi), amma raguwa a cikin LDL cholesterol yana kama da wannan tare da yin amfani da atorvastatin ba tare da abinci ba. Hankalin atorvastatin lokacin da aka shafa shi da maraice yana ƙasa da safiya (kusan 30%). An bayyana alaƙar layin tsakanin matakin ɗaukar kwayar cutar.
Bioavailability - 14%, tsari na bioavailability na hanawa aiki ta hanawa HMG-CoA rage- 30%. Systemarancin tsarin bioavailability yana faruwa ne ta dalilin tsarin ƙwaƙwalwar ƙwayar cuta a cikin ƙwayar mucous na ƙwayar jijiyoyin ciki da kuma yayin "hanyar farko" ta hanta.
Matsakaicin matsakaiciyar rarraba shine 381 l, haɗin tare da kariyar plasma jini shine 98%.
Yana da metabolized a cikin hanta a ƙarƙashin aikin cytochrome P450 CYP3A4, CYP3A5 da CYP3A7 tare da samuwar magunguna masu aiki da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta (ortho- da para-hydroxylated, samfuran beta-hada abubuwa).
Sakamakon inhibitory na miyagun ƙwayoyi a kan ragewar HMG-CoA shine kusan kashi 70% wanda aka ƙaddara ta hanyar ayyukan kewaya metabolites.
An cire shi cikin bile bayan hepatic da / ko metabolhe metabolism (baya fuskantar matsanancin yanayin maganin cutar ciki).
Rabin rayuwar shine awoyi 14. Ayyukan hana haɓakawa da hanawa HMG-CoA ragewa yai kusan tsawon awanni 20-30, saboda kasancewar metabolites mai aiki. Kasa da 2% na maganin baka an ƙaddara shi a cikin fitsari.
Ba a keɓance shi a lokacin hemodialysis ba.

Alamu don amfani

Babban hypercholesterolemia, hadewar hyperlipidemia, heterozygous da hyzycholesterolemia na hyzycholesterolemia (a matsayin ƙari ga abinci).

Hypersensitivity ga kowane daga cikin abubuwan da ke cikin miyagun ƙwayoyi, cutar hanta a cikin matakin aiki (ciki har da ƙwayar hepatitis mai aiki, ƙwaƙwalwar ƙwayar cuta ta jiki), ƙaruwar ƙwayoyin hepatic transaminases (fiye da sau 3 idan aka kwatanta da babba na al'ada) na asalin da ba a sani ba, gazawar hanta (tsananin tsananin A da B bisa ga tsarin yara-Pyug), cirrhosis na kowane etiology, ciki, lactation, shekaru har zuwa shekaru 18 (ba a kafa inganci da aminci ba).

Tare da kulawa: tarihin cutar hanta, matsanancin ƙwaƙwalwar ƙwayar cuta, rashin daidaituwa na endocrine da cuta na rayuwa, shan giya, cututtukan mahaifa, matsanancin ciwo na ciki (sepsis), tashin hankali, ba da kulawa sosai, tiyata mai yawa, raunin da ya faru.

Sashi da gudanarwa

Kafin fara magani tare da Liptonorm, ya kamata a tura mai haƙuri zuwa abincin da ke tabbatar da raguwar lipids na jini, wanda dole ne a lura yayin lura tare da miyagun ƙwayoyi.
A ciki, ɗauka a kowane lokaci na rana (amma a lokaci guda), ba tare da la'akari da cin abinci ba.
Maganin farawa shine 10 MG sau ɗaya a rana. Na gaba, an zaɓi kashi ɗaya daban-daban dangane da kwayar cholesterol - LDL. Ya kamata a canza kashi tare da wani tazara na akalla makonni 4. Matsakaicin kullun shine 80 MG a cikin 1 kashi.

Primary (heterozygous gado da polygenic) hypercholesterolemia (nau'in IIa) da cakuda hyperlipidemia (nau'in IIb)
Jiyya yana farawa da shawarar farko da aka ba da shawarar, wanda aka ƙaruwa bayan makonni 4 na maganin, dangane da amsar mai haƙuri. Matsakaicin adadin yau da kullun shine 80 MG.

Homozygous maganin gadoji
Matsakaicin adadin iri ɗaya ne da na sauran nau'in hyperlipidemia. An zaɓi kashi na farko akayi daban-daban dangane da tsananin cutar. A cikin mafi yawan marasa lafiya tare da hyzycholesterolemia na homozygous, ana lura da ingantaccen sakamako lokacin amfani da miyagun ƙwayoyi a cikin adadin yau da kullun na 80 MG (sau ɗaya).

A cikin marasa lafiya da gazawar renal kuma a cikin marasa lafiya tsofaffi, ba a buƙatar daidaita sashi na Liptonorm.
A cikin marasa lafiya da ke fama da rauni na hanta, ya kamata a yi taka tsantsan dangane da jinkirin kawar da miyagun ƙwayoyi daga jiki. Ya kamata a kula da sigogin asibiti da dakin gwaje-gwaje a hankali, kuma idan an gano manyan canje-canje na cututtukan cuta, ya kamata a rage kashi ko magani ya kamata a daina.

Daga tsarin juyayi na tsakiya: a cikin fiye da 2% na lokuta - rashin bacci, farin ciki, a cikin ƙasa da 2% na lokuta - ciwon kai, cututtukan asthenic, malaise, nutsuwa, mafarki mai ban tsoro, matsananciyar damuwa, ciwon mara, rashin damuwa, ciwon zuciya, rashin damuwa, ataxia, jijiyoyin jijiyoyin jiki, ciwon zuciya, rashin damuwa, damuwa hyperesthesia, asarar sani.
Daga hankula: amblyopia, ringing a cikin kunnuwa, bushewar conjunctiva, tashin hankali na masauki, zubar jini a idanun, kunnuwa, glaucoma, parosmia, asarar dandano, rudewar dandano.
Daga tsarin zuciya: a cikin fiye da 2% na lokuta - ciwon kirji, a cikin ƙasa da 2% - palpitations, vasodilation, migraines, hypotension, hauhawar jini, phlebitis, arrhythmia, angina pectoris.
Daga tsarin hawan jini: anaemia, lymphadenopathy, thrombocytopenia.
Daga tsarin numfashi: a cikin fiye da 2% na lokuta - mashako, rhinitis, a cikin ƙasa da 2% na lokuta - ciwon huhu, dyspnea, mashako, ƙwanƙwasa hanci.
Daga tsarin narkewa: a cikin fiye da 2% na lokuta - tashin zuciya, ƙwannafi, maƙarƙashiya ko zawo, flatulence, gastralgia, ciki na ciki, anorexia ko ƙara yawan ci, bushe baki, belching, dysphagia, vomiting, stomatitis, esophagitis, glossitis, erosive da ulcerative raunuka na mucous membrane daga cikin kogin bakin, gastroenteritis, hepatitis, hepatic colic, cheilitis, ulcer duodenal, pancreatitis, cholestatic jaundice, aikin hanta mai rauni, zub da jini na hanji, melena, zub da jini, gogewar jiki.
Daga tsarin musculoskeletal: a cikin fiye da 2% na lokuta - amosanin gabbai, a cikin ƙasa da 2% na lokuta - ƙwanƙwashin ƙwaƙwalwar ƙafa, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, hauhawar tsoka, haɗin gwiwa.
Daga tsarin kulawa: a cikin fiye da 2% na lokuta - cututtukan urogenital, farji na ciki, a cikin ƙasa da 2% na lokuta - dysuria (ciki har da pollakiuria, nocturia, urinary incontinence ko urinary riƙewa, m urination), nephritis, hematuria, fitsarin farji, nephrourolithiasis, metrorrhagia, epididymitis, rage libido, rashin ƙarfi, ciwan ciki.
A bangare na fata: kasa da 2% na lokuta - alopecia, xeroderma, karuwar gumi, eczema, seborrhea, ecchymosis, petechiae.
Allergic halayen: a cikin ƙasa da 2% na lokuta - itching, fatar fata, tuntuɓar dermatitis, da wuya - urticaria, angioedema, facial edema, photosensitivity, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, mai guba da epidermal necrolysis (cutar Lyell ta).
Manunin dakin gwaje-gwaje: kasa da 2% na lokuta sune hyperglycemia, hypoglycemia, karuwa a cikin ƙwayar ƙwayar ƙwayar ƙwaƙwalwa na ƙwayoyin cuta, alkaline phosphatase, albuminuria, karuwa a alanine aminotransferase (ALT) ko aspartic aminotransferase.
Sauran: kasa da 2% na lokuta - yawan nauyi, gynecomastia, mastodynia, ƙari na gout.

Yawan abin sama da ya kamata

Jiyya: babu takamaiman maganin rigakafi. Ana gudanar da aikin tiyata. Suna ɗaukar matakai don kiyaye mahimman ayyukan jiki da kuma matakan hana ƙarin shan ƙwayoyi: ƙwayar ciki, cinikin gawayi. Hemodialysis ba shi da tasiri.
Idan akwai alamu da kasancewar abubuwanda ke tattare da haɗari don haɓaka ƙarancin ƙarancin ƙwayar cuta saboda rhabdomyolysis (mara wuya amma mummunan sakamako masu illa), yakamata a dakatar da maganin nan da nan.
Tunda atorvastatin yana da alaƙa da sunadaran plasma, hemodialysis hanya ce mara amfani don cire wannan abu daga jiki.

Yin hulɗa tare da wasu kwayoyi

Tare da gudanarwa na lokaci daya na cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, antifungal kwayoyi (da suka shafi azoles) da nicotinamide, haɗuwa da atorvastatin a cikin jini na jini (da kuma haɗarin myopathy) yana ƙaruwa. Antacids yana rage taro da kashi 35% (sakamakon tasirin LDL cholesterol baya canzawa).
Amfani da atorvastatin tare da hanawar kariya wanda aka sani da CYP3A4 cytochrome P450 inhibitors yana haɗuwa tare da karuwa a cikin ƙwayoyin plasma na atorvastatin.
Lokacin amfani da digoxin a hade tare da atorvastatin a kashi 80 na MG / rana, yawan ƙwayoyin digoxin yana ƙaruwa da kusan 20%.
Rationara yawan hankali da kashi 20% (lokacin da aka ƙera shi da atorvastatin a kashi 80 na MG / rana) na maganin hana haihuwa wanda ke ɗauke da northindrone da etinyl estradiol.
Sakamakon rage ƙwayar lipid na haɗuwa tare da colestipol ya fi waccan ga kowane ƙwayoyi daban-daban.
Tare da gudanarwa na lokaci daya tare da warfarin, lokacin prothrombin yana raguwa a cikin kwanakin farko, duk da haka, bayan kwanaki 15, wannan alamar ta daidaita. A wannan batun, marasa lafiya waɗanda ke shan atorvastatin tare da warfarin ya kamata su fi dacewa fiye da yadda aka saba don sarrafa lokacin prothrombin.
Yin amfani da ruwan 'ya'yan innabi a lokacin jiyya tare da atorvastatin na iya haifar da karuwa a cikin ƙwayar ƙwayar cuta a cikin jini na jini. A wannan batun, marasa lafiya da ke shan maganin ya kamata su guji shan wannan ruwan 'ya'yan itace.

Umarni na musamman

Rashin aikin hanta
Yin amfani da Hhib-CoA reductase inhibitors don rage yawan lipids na jini zai iya haifar da canji a cikin sigogin ƙirar ƙwayoyin halitta wanda ke nuna aikin hanta.
Ya kamata a kula da aikin hanta kafin magani, makonni 6, makonni 12 bayan fara Liptonorm kuma bayan kowane kashi yana ƙaruwa, kuma lokaci-lokaci, alal misali, kowane watanni 6. Ana samun sauyi a cikin ayyukan hanta enzymes a cikin farkon watanni ukun farko bayan fara shan Liptonorm. Ya kamata a kula da marasa lafiya da haɓaka matakan transaminase har sai matakan enzyme sun koma al'ada. A cikin abin da ya faru da dabi'u na alanine aminotransferase (ALT) ko aspartic aminotransferase (AST) sun fi sau 3 girman matakin da aka yarda da na sama, ana bada shawara don rage yawan maganin Liptonorm ko dakatar da magani.

Saƙar fata
Marasa lafiya tare da rarrabuwar myalgia, sahihanci ko rauni na tsoka da / ko gagarumin karuwa a cikin KFK suna wakiltar rukuni mai haɗari don haɓakar cutar sankarar mahaifa (wanda aka bayyana shi azaman tsoka tare da karuwa a cikin KFK fiye da sau 10 idan aka kwatanta da babba na al'ada).
Lokacin da ake rubuta maganin haɗin gwiwa na Liptonorm tare da cyclosporine, abubuwan da ake amfani da su na fibric acid, erythromycin, clarithromycin, immunosuppressants, da magungunan antifungal na tsarin azole, kazalika da allurai na niacin waɗanda ke haifar da raguwa a cikin matakan ƙwayar ƙwayar cuta, yana da mahimmanci don kwatanta mahimman fa'idodi da ƙimar haɗari tare da wannan jiyya da kuma haƙuri wanda alamunsu ko alamomin raunin ƙwayar tsoka, ɓacin rai ko rauni sun bayyana, musamman a farkon watanni na jiyya kuma tare da haɓaka kashi na kowane Reparata.

Jiyya tare da Liptonorm ya kamata a dakatar da shi na ɗan lokaci ko dakatar da shi idan mummunan yanayi ya taso wanda zai iya haifar da ta hanyar myopathy, haka kuma idan akwai abubuwan haɗari don haɓakar rashin lafiyar koda sakamakon rhabdomyolysis (alal misali matsanancin kamuwa da cuta, matsanancin jijiya, ƙwararrun tiyata, rauni, matsanancin rauni, rauni, matsananciyar rauni cuta na ciki da na endocrine, da rashin daidaituwar lantarki).
A cikin mata masu haihuwa da basa amfani da rigakafin samun abin dogaro, ba a shawarar amfani da Liptonorm. Idan mara lafiyar yana shirin yin juna biyu, to ya kamata ta daina shan Liptonorm aƙalla wata guda kafin ɗaukar ciki.
Mai haƙuri yakamata ya nemi likita nan da nan idan ciwo mara bayyana ko rauni na tsoka ya faru, musamman idan suna tare da zazzaɓi da zazzaɓi.

Tasiri kan iya tuƙin mota da aiki tare da kayan aiki

Ba a ruwaito sakamako masu illa na Liptonorm kan iya tuƙi mota da aiki tare da kayan aikin da ke buƙatar ƙara yawan kulawa ba.

Fom ɗin saki

Allunan mai rufi na 10 da 20 MG.
A kan allunan 7, 10 ko 14 a cikin alluran Al / PVC.
1, 2, 3, 4 blister a cikin kwalin kwali tare da umarnin don amfani.

Yanayin ajiya

Jerin B. A cikin bushe, wuri mai duhu a zazzabi ƙasa da 25 ° C.
Ayi nesa da isar yara.

Ranar karewa

Shekaru 2 Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Sharuɗɗan hutu na kantin

Mai masana'anta:
"M.J. Biopharm", India
113 Jolly Maker Chambers-II, Nariman Point, Mumbai 400021, India
Tele: 91-22-202-0644 Faksi: 91-22-204-8030 / 31

Wakilai a Tarayyar Rasha
119334 Rasha, Moscow, ul. Kosygina, 15 (GC Orlyonok), ofis 830-832

Kunshi:
Pharmstandard - Leksredstva OJSC
305022, Russia, Kursk, ul. Kashi Na Biyu, 1a / 18.
Tel / Faksi: (07122) 6-14-65

Abun ciki, sakin saki

Ingancin sinadarin Liptonorm shine atorvastatin. An haɗu da shi tare da abubuwa masu taimako: carbonate carbonate, cellulose, sukari madara, cellulose hydroxypropyl, croscarmellose, magnesium stearate, titanium dioxide, polyethylene glycol.

Liptonorm wani farin farin tebur ne, mai zagaye. Akwai bambance-bambance guda biyu na miyagun ƙwayoyi tare da abun aiki mai aiki na 10 ko 20 MG.

Aikin magunguna

Atorvastatin shine mai hana mutum HMG-CoA reductase inhibitor. Wannan enzyme ya zama dole ga jikin mutum ya samar da cholesterol. Kwayoyin Liptonorm suna kama da juna. Kwayoyin hanta suna ɗaukar shi don enzyme, sun haɗa da amsawar samuwar cholesterol - yana tsayawa. Bayan duk wannan, kadarorin atorvastatin ba su da alaƙa da Htr-CoA reductase.

Matakan cholesterol suna faduwa. Don ramawa game da rashi, jikin ya fara rushe kwayoyin da ke ɗauke da LDL, wanda ke haifar da raguwa a cikin ƙwaƙwalwar su. Sourcearin tushen tasirin cholesterol shine sashin jiki. Don kawo jigilar jigilar jigilar kwayoyi, ana buƙatar “lipoproteins” mai ƙarfi mai yawa. Dangane da wannan, adadinsu yana ƙaruwa.

Ragewa a cikin jimlar cholesterol, LDL, triglycerides yana rage jinkirin ci gaban atherosclerosis. Tun da wuce haddi kayayyakin mai mai yana da ikon tarawa a saman jijiyoyin jini. Lokacin da adibin ya zama mahimmanci, yana jujjuya shi ko gaba ɗaya yana rufe daɓen jirgin ruwa. Atherosclerosis na tasoshin zuciya yana haifar da bugun zuciya, bugun kwakwalwa, wata gabar jiki - samuwar cututtukan cututtukan trophic, necrosis ƙafa.

Inganci na atorvastatin an rage shi zuwa sifili idan mutum bai bi abincin da ake shirin rage cholesterol ba. Jiki ba ya kashe abin da yake amfani da shi wajen rufe karancin abubuwan hawa, saboda abinci ne.

Kwayoyin cholesterol sun fara zama al'ada bayan makonni 2 daga fara shan kwayoyin. Ana samun sakamako mafi girma bayan makonni 4.

Atorvastatin metabolites yana da kyau a cikin bile, wanda hanta ke samar dashi. Tare da gazawar ƙwayar cuta, wannan tsari ya zama mafi wahala. Sabili da haka, tare da cututtukan hanta, an tsara maganin a hankali.

Liptonorm: alamomi don amfani

Dangane da umarnin don amfani da Liptonorm, an wajabta magunguna azaman kari don maganin abinci don:

• na farko hypercholesterolemia,
• Cakuda maganin cuta,
• heterozygous da homozygous familial hypercholesterolemia a matsayin ƙari ga ilimin abinci,

Amfani da atorvastatin yana taimaka wajan rage hadarin bugun zuciya, bugun zuciya a cikin marassa lafiya da cututtukan zuciya. Bugu da kari, marassa lafiya da ke shan Liptonorm sau da yawa suna bukatar rufewa, tsintuwa, asibiti tare da matsalolin zuciya.

Hanyar aikace-aikacen, sashi

Kafin fara magani tare da Liptonorm, haka kuma a duk tsawon lokacin, mai haƙuri dole ne ya bi abincin.

Allunan ana ɗauka sau ɗaya / rana, ba tare da ambaton abinci ba, amma koyaushe a lokaci guda. Ana shawarar farawa shine 10 MG. Bugu da ƙari, an zaɓi sashi daban-daban, la'akari da sauye-sauye na canje-canje a cikin cholesterol, LDL. Ana aiwatar da gyaran sashi ba fiye da 1 lokaci / 4 makonni ba. Matsakaicin adadin izini shine 80 MG. Tare da raunin rauni na jiki don ɗaukar atorvastatin, an wajabta mai haƙuri mafi kyawun statin ko ƙarin tare da wasu kwayoyi waɗanda ke rage ƙwayar cholesterol (jerin abubuwan bile acid, masu hana ƙwayoyin cholesterol).

Tare da gazawar hanta, nadin Liptonorm ya kamata ya kasance tare da saka idanu akan aikin jikin. Idan sun fi karfin al'ada, an soke magunguna ko kuma an rage musu ajiyar magani.

Contraindications, sakamako masu illa

Liptonorm yana cikin contraindicated a cikin mutanen da suke kula da atorvastatin, lactose, kowane bangaren na miyagun ƙwayoyi ko analog. Allunan suna contraindicated a cikin:

• m hanta cututtuka
• karuwa a cikin AlT, GGT, AST fiye da sau 3,
• mummunan cututtuka
• cirrhosis
• yara ‘yan kasa da shekara 18.

Ba a sanya maganin liptonorm ga mata masu juna biyu, da masu shayarwa ba. Idan an shirya juna biyu, za a dakatar da maganin a kalla wata guda kafin wannan ranar. Tare da cikin da ba a tsara ba, dole ne a daina shan miyagun ƙwayoyi, sannan kuma tuntuɓi likita nan da nan. Zai yi magana game da haɗarin yiwuwar tayin, kuma ya ba da shawarar zaɓuɓɓuka don aiwatarwa.

Yawancin marasa lafiya a sauƙaƙe suna jure wa magani. Sakamakon sakamako, idan akwai, mai laushi, yana ɓacewa bayan ɗan gajeren lokaci. Amma wataƙila ƙasa da tsammanin ci gaban abubuwan da ke faruwa.

Koyarwar Liptonorm yayi kashedin game da tasirin sakamako masu zuwa:

• Tsarin mara lafiyar: yawanci rashin bacci, tsananin farin ciki, da wuya ciwon kai, zazzabin cizon sauro, bacci, bacci, rashin lafiya, raguwa / karuwar jijiyoyin jiki, jijiyoyin jiki, tashin hankali, rashin daidaituwa, yanayin gyara jijiyoyin jijiya, raunin hankali.
• Gabobin jijiyoyi: hangen nesa biyu, ringin kunne, idanun bushe, kurma, glaucoma, rudewar jijiya.
• Tsarin zuciya: sau da yawa - ciwon kirji, da wuya migraine, palpitations, hypotension or hauhawar jini, arrhythmia, angina pectoris, phlebitis.
• Tsarin numfashi: sau da yawa - mashako, rhinitis, da wuya - ciwon huhu, asma, ciwan hanci.
• Tsarin narkewa: tashin zuciya, ƙwannafi, maƙarƙashiya ko zawo, ciwon ciki, gas, anorexia ko ƙarancin abinci, bushewar bushe, ƙwanƙwasawa, haɗiyewa, amai, kumburi, kumburi, harshe, gastroenteritis, hepatitis, hepatic colic, duodenal ulcer , cututtukan farji, farji, farji, aikin hanta mai rauni, zubar jini na hanji, amai.
• Tsarin Musculoskeletal: sau da yawa - amosanin gabbai, da wuya - ƙuƙwalwar ƙwayar ƙafa, bursitis, ciwon haɗin gwiwa, myositis, myopathy, myalgia, rhabdomyolysis, ƙarar sautin tsoka.
• Tsarin ƙwayar cuta: sau da yawa - cututtukan ƙwayar cuta, cututtukan mahaifa, da wuya - dysuria, kumburi da kodan, zubar farji, kumburi daga cikin ɗakunan gwaje-gwajen, raguwar libido, rashin ƙarfi, rashin ciwan ciki.
• Fatar: alopecia, haɓaka mai ɗaci, eczema, dandruff, basur.
• Allergic halayen: itching, kurji, lamba dermatitis, urticaria, tashin zuciya, tashin hankali, daukar hoto, anaphylaxis.
• Manuniyar dakin gwaje-gwaje: sukari mai yawa / ƙarami, ƙara yawan CPK, alkaline phosphatase, ALT, AST, GGT, anemia, thrombocytopenia.
• Sauran: riba mai nauyi, gynecomastia, ƙari na gout.

Mafi sau da yawa, masu shan sigari, masu shan giya, marasa lafiya da ciwon sukari, rashin isasshen thyroid, cututtukan hanta, hypotension suna fama da sakamako masu illa.

Dakatar da Liptonorm, kuma tuntuɓi likitanku idan:

• matsanancin rauni da ba a bayyana ba ko rauni,
• yawan zafin jiki
• katsewa.

Haɗa kai

Kwayoyi na iya amsawa tare da waɗannan kwayoyi:

• antacids (omeprazole, almagel),
• digoxin
• amadamarke, clarithromycin,
• masu hana masu kariya
• wasu hana haihuwa
• zaren wuta
• warfarin
• itraconazole, ketoconazole.

Ba a sayar da miyagun ƙwayoyi ba ta hanyar magunguna a Rasha. Ya ƙare da takardar rajista. Farashin Liptonorm a lokacin ɓacewa daga siyarwar shine 284 rubles a kowane 10 mg, 459 rubles a 20 MG.

Rashin magunguna na Liptonorm ba matsala. Akwai magungunan analogues da yawa na miyagun ƙwayoyi tare da abu guda mai aiki. Kuna iya tambaya a cikin kantin magunguna:

• Atoris
• Anvistat
• Atomax
• Ator
• Tulip
• Atorvastitin-OBL,
• Atorvastatin-Teva,
• Atorvastatin MS,
• Atorvastatin Avexima,
• Atorvox
• Vazator
• Lipoford
• Liprimar
• Novostat,
• Torvas
• Torvalip
• Thorvacard
• Torvazin.

Baya ga magungunan da ke sama, zaku iya ɗaukar kayan maye na Liptonorm ta hanyar aikin:

• simvastatin - 144-346 rubles.,
• lovastatin - 233-475 rubles.,.
• rosuvastatin - 324-913 rub.,
• fluvastatin - 2100-3221 rub.

Duk statins suna da tsarin aikin abu ɗaya, amma kowannensu yana da abubuwan amfani. Sabili da haka, koyaushe tuntuɓi likita kafin canza magani.

Abubuwan da marubutan aikin suka shirya
bisa ga tsarin edita na shafin.

Formaddamar da tsari da abun da ke ciki

Ana samun Liptonorm a cikin nau'ikan allunan: mai rufi da farin harsashi, zagaye, biconvex, a hutu - fari ko kusan fararen (pc. 14. A cikin blisters, blisters 2 a cikin kwali na kwali).

Abubuwan da ke aiki da miyagun ƙwayoyi shine atorvastatin (a cikin nau'in gishiri na alli). A cikin kwamfutar hannu 1 ya ƙunshi 10 ko 20 MG.

Wadanda suka kware: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, tween 80, lactose, hydroxypropyl methyl cellulose, microcrystalline cellulose, titanium dioxide, kalisiomu karafa, polyethylene glycol.

Abun ciki da sashi tsari

Babban abu mai narkewa na Liptonorm shine Atorvastatin alli wanda aka samar dashi a cikin sinadarin gishiri. Daga cikin kayan tallafin nasa sun hada da:

• carbonate carbonate
• Twin 80,
• MCC
• ƙarin kayan abinci E463 da E572,
• croscarmellose sodium
• lactose
• tsarkakakken ruwa.

Ana samar da Liptonorm a cikin kwamfutar hannu. Allunan da aka rufe na 10 MG ko MG 20 suna samuwa a cikin adadin 7, 10, 14, 20, 28 ko 30 inji mai kwakwalwa.

Alamu don amfani

An wajabta maganin don kara yawan ƙwayoyin cuta. Ayyukanta na da nufin hana sinadarin lipid cikin jini. Ya kamata a yi amfani da Liptonorm a satin da likita ya umarta.

Magungunan Liptonorm yana da rawar gani iri-iri. Magungunan yana da rage rage ƙarfin lipid da anti-atherosclerotic sakamako. Sakamakon rage ƙwayar lipid na ƙwayar Liptonorm shine cewa abu mai aiki yana ba da gudummawa ga hana cholesterol da kuma cire ƙwayoyin LDL daga jini na jini.

Tasirin anti-atherosclerotic yana dogara ne akan gaskiyar cewa maganin yana da ikon murƙushe haɓakar sel a cikin tasoshin jini da rage abubuwan da ke cikin abubuwan haɗin jini. Sakamakon yawaitar aikin, ya kamata a tsara maganin don cututtukan da ke gaba:

• Halittar kwayoyin halittar jiki don wuce kima mai yawa,
• dyslipidemia,
• hetero - ko nau'in homozygous na nau'in familial hypercholesterolemia.

Kada ya kamata a rikitar da Liptonorm tare da miyagun ƙwayoyi don asarar nauyi Liponorm. Baya ga gaskiyar cewa ƙarshen shine karin kayan abinci, ana siyar da shi kawai a cikin capsules.

Side effects

Idan mara lafiya ya yi watsi da contraindications ko ya wuce adadin magungunan da aka kayyade masa, to za a iya shafar hadarin sakamakonsa. Rashin bin ka'idodi na rashin lafiya na iya haifar da shan kashi mai zuwa tsarin da gabobin:

1. CNS Babban abubuwanda ke haifar da mummunan aiki na tsarin juyayi shine tsananin wahala da tashin hankali na bacci. A cikin maganganun da ke cikin rashi, marassa lafiya suna fuskantar alamu irin su mafarki mai ban tsoro, asthenia, ataxia, paresis da hyperesthesia, wanda ke haifar da tsawan rai.
2. Gabobin ciki. Alamar cin zarafin ayyukansu shine zubar jini a cikin ƙwallon ido, rashi na rashin ruwa yayin aiki, asarar ikon gano kamshi.
3. Tsarin ƙwayar cuta. Cutar cututtukan mahaifa da na farji, matsalolin urination, haɓakar ƙarancin rashin haihuwa a lokacin jiyya, tenanƙantar da ƙarfi sune halayen da suka fi dacewa yayin jiyya tare da Liptonorm.
4. Tsarin Lymphatic. Hanyar likita na iya haifar da ci gaba da cututtukan jini - lymphadenopathy, anemia ko thrombocytopenia.
5. Maganin narkewa. Rashin bin ka'idodin sashi na allunan bisa ga umarnin yana haifar da ci gaban cututtukan cututtukan hanji da hanta, waɗanda ke nunawa ta hanyar ɓarna, jita-jita, matsananciyar farfadowa, hanta colic, har ma da hepatitis.
6. Tsarin zuciya. Marasa lafiya na iya fuskantar hauhawar jijiyoyin jini, angina pectoris, matsawa kirji.
7. Tsarin haɗin kai Matsalar cututtukan fata ko rashin lafiyan sun hada da rashes, itching, seborrhea, eczema, da wuya urticaria ko anaphylactic shock.

Umarnin don amfani

Liptonorm wakili ne na rukunin magungunan da ake amfani da su wajen magance matakan wuce kima na ma'aunin lipid. Atorvastatin - kayan aiki na yau da kullun, yana da tasiri mai saurin rage kiba, wato, yana taimakawa rage abun cikin lipid a cikin jini. Abun da ke cikin sa yana tashi sama da awa 1 bayan aikace-aikacen. Da safe, wannan adadi ya kusan kashi 30% sama da maraice.

Sakamakon amfani da statins an lura da shi bayan kwanaki 14. Ana samun sakamako mafi girman kawai bayan watanni 1 na amfani.

Shan maganin ba ya dogara da shigar abinci abinci a jiki. Halin kawai wanda ke ba da gudummawa ga tasiri na amfani da miyagun ƙwayoyi shine yawan shan allunan a lokaci guda. Kada haƙuri ya wuce madaidaiciya - 10 MG kowace rana. Wuce sashi na yau da kullun na iya haifar da babbar illa ga lafiya kuma yana haifar da halayen da ba a so.

Kafin farawa likita, likitoci ya kamata su kula da aikin hanta. Masana sun ba da shawarar yin taka tsantsan da kuma ziyartar likita a kai a kai don lura da aikin hanta na watanni 3 na farko bayan farawar magani. Ana iya aiwatar da gyaran fuska ta makonni da yawa bayan fara magani, amma ba sau da yawa fiye da 1 lokaci na wata daya. A lokacin shigarwar, likitoci ya kamata kowane watanni 6. sarrafa canje-canje a ma'auni na enzyme.

Dangane da yanayin amfani, dole ne a adana allunan a cikin wuri mai sanyi. Manunin zazzabi a cikin wannan ɗakin +25 digiri.

Yi amfani yayin daukar ciki

An haramta amfani da sinadaran magani ga marasa lafiya yayin daukar ciki da lokacin shayarwa (shayarwa) saboda yiwuwar mummunan tasirin akan jikin jariri. Idan mara lafiya yana shirin daukar ciki, zai fi kyau ka watsar da shi tsawon watanni. Mata a lokacin jiyya tare da Liptonorm kada su manta da hana haihuwa.

Sauran magungunan sun hada da yara da kuma lokacin balaga. Ba a samun bayani game da kula da yara tare da magani har zuwa yanzu.

Farashin magani

Farashin maganin Liptonorm an ƙaddara shi da sharuɗɗa da yawa - yawan adadin blisters a cikin kunshin, sashi, da dai sauransu. A matsakaici, za'a iya sayan allunan 10 MG a kantin magani don 200-250 rubles. Kudin fakitin fakiti 28. Mita 20 kowane ɗaya shine 400-500 rubles.

A cikin Ukraine, farashin magani a cikin sashi na 20 MG shine 250-400 UAH.

Analogs Liptonorm

Duk da cewa Liptonorm magani ne mai matuƙar tasiri, bai dace da duk masu haƙuri ba. Rashin hankalin mutum zuwa ga ɓangaren kwayoyi da shaye-shaye sune manyan dalilai biyu na maye gurbinsa da isharar mai rahusa.

Wadannan magunguna masu zuwa suna daga analog na Liptonorm:

Yin Amfani da Bita

Binciken da aka yi amfani da shi ya nuna cewa likitoci sukan ba da magani ga mai haƙuri ba tare da cikakkun bayanai game da abubuwan da ke tattare da gudanarwarsa ba.

Tamara, Moscow: "A cikin kwanakin farko bayan na sha kwayoyin, na fara jin ciwo a ciki na, sai na fashe da kuka a ciki, 'yan kwanaki kadan - tashin zuciya da amai. Ban taɓa haɗa waɗannan bayyanar da shan Liptonorm ba. Tun da na kasance ina fama da rikice-rikice na ƙwayar gastrointestinal tun daga ƙuruciya tare da ƙaramin canji a cikin abincincina, nan da nan na juya zuwa masanin ilimin gastroenterologist. Godiya ga likita, na gano abin da ya haifar da rashin jin daɗi a cikin ciki, amma har yanzu ina kula da tambayar. Me ya sa mai hana ni abinci na gargadin game da sakamakon na iya faruwa? "

Katarina, Novosibirsk: “Yawan nauyin da nake da shi ya kasance tare da ni tun ina matashi, amma sai da na cika shekara 30 da yanke hukuncin kula da kaina tare da gano dalilin matsalata. Karatun dakin gwaje-gwaje ya nuna cewa sanadin cutar kwayar cutar kwayar cuta ce kuma mai gina jiki ya ba ni Liptonorm.A ranar farko, hawan jini na ya hau zuwa 150. Kashegari da safe matsin lamba ya zama al'ada, amma bayan abincin rana ya sake tsalle zuwa 160. Bayan haka na yanke shawarar sake karanta umarnin kuma a ƙarshe na fahimci abin da ke faruwa. Hawan jini na shine tasirin magani. Matsin lamba ya daina tsawan kwanaki 5 bayan fara maganin. ”

Takaita dukkanin bayanan da aka ambata a sama game da amfani da allunan Liptonorm, ya kamata a kammala da cewa lallai ne a nemi likita kafin amfani da su. Da fari dai, wannan ya faru ne saboda gaskiyar cewa maganin yana cikin rukunin gumakan da zasu iya magance karuwar ƙwayoyin cholesterol. Kamar yadda kuka sani, alƙawarin ko soke duk wani wakili na hormonal zai iya gudana ne ta kwararru.

Abu na biyu, ƙwayar tana da nau'ikan contraindications da sakamako masu illa daga jijiyoyi, tsarin jijiyoyi na tsakiya, cututtukan zuciya da sauran mahimman tsarin. Kwararren likita yakamata ya bayar da magani, ya bayyana dukkan siffofin aikace-aikacen, sannan kuma ya sanar da mara lafiya game da rikitattun matsalolin.

Sashi da gudanarwa

Kafin rubuta Liptonorm da kuma tsawon lokacin amfani da shi, mai haƙuri yakamata ya bi abincin da ke samar da raguwar yawan lipids na jini.

Ana shan maganin a baki sau 1 a rana, ba tare da cin abinci ba, a lokaci guda.

Maganin farko na yau da kullun yawanci shine 10 mg. Bayan haka, ana daidaita sashi daban-daban, gwargwadon abubuwan da ke cikin cholesterol na ƙarancin lipoproteins mai yawa. Tazara tsakanin canje-canjen kashi bai kamata ya zama ƙasa da makonni 4 ba. Matsakaicin izini na yau da kullun shine 80 MG.

Side effects

Sakamakon sakamako masu illa na miyagun ƙwayoyi (sau da yawa - fiye da 2%, da wuya - ƙasa da 2%):

• Tsarin juyayi na tsakiya: sau da yawa - tsananin farin ciki, rashin bacci, da wuya - malaise, asthenic syndrome, amai, ciwon kai, mafarki mai ban tsoro, ciwon zuciya, ciwon zuciya, ciwon kai, ciwon mara, fuska, ciwon zuciya, ciwon ciki, rashin bacci, rashin hankali
• Tsarin zuciya: yawanci ciwon kirji, da wuya postpot hypotension, arrhythmia, vasodilation, hawan jini, angina pectoris, hawan jini, phlebitis,
• Kwayoyin jijiyoyin jiki: bushe conjunctiva, glaucoma, zubar jini, amblyopia, tashin hankali na masauki, parosmia, ringing a cikin kunnuwa, kurma, gurguwar dandano, asarar dandano,
• Tsarin numfashi: sau da yawa - rhinitis, mashako, da wuya - hanci, ciwan huhu, asma, dyspnea,
• Tsarin narkewa: sau da yawa - cheilitis, gumis na zub da jini, kazantawa da raunuka na bakin mucosa, stomatitis, glossitis, bushewar bakin, yatsun kafa, maƙarƙashiya ko zawo, ƙwannafi, ƙonewa, tashin zuciya, tashin zuciya, gastralgia, belching, pain pain, vomiting, dysphagia , esophagitis, anorexia ko karin yawan ci, ciwan duodenal, hepatic colic, gastroenteritis, hepatitis, aikin hanta mai rauni, cholestatic jaundice, pancreatitis, melena, fitsari na hanji,
• Tsarin ƙwayar cuta: sau da yawa - yanki na gefe, cututtukan urogenital, da wuya - hematuria, nephritis, nephrourolithiasis, dysuria (ciki har da urinary incontinence ko urinary riƙewa, nocturia, pollakiuria, urination m), metrorrhagia, fitsarin farji, epididymitis, kawowa, raguwar libido, rashin ƙarfi,
• Tsarin Musculoskeletal: sau da yawa - arthritis, da wuya - tendosynovitis, bursitis, myositis, myalgia, arthralgia, torticollis, cramps kafa, kwancen haɗin gwiwa, hauhawar tsoka, myopathy, rhabdomyolysis,
• Tsarin hematopoietic: lymphadenopathy, anemia, thrombocytopenia,
• Cututtukan fata da rashin lafiyan halayen jiki: da wuya - ƙara yawan yin zagi, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, itching, fatar fata, likitan fata, da wuya - facial edema, angioedema, urticaria, photosensitivity, multiform exudative erythema, erythema erythema Stevens-Johnson ciwo, anaphylaxis,
• Manuniya na dakin gwaje-gwaje: da wuya - albuminuria, hypoglycemia, hyperglycemia, karuwar ayyukan alkaline phosphatase, ƙwayar halittar phoinhokinase phosphokinase da hepatic transaminases,
• Sauran: da wuya - mastodynia, gynecomastia, yawan nauyi, karuwar gout.

Umarni na musamman

A duk tsawon lokacin magani, bin diddigin alamun likitanci da dakin gwaje-gwaje na alamun jikin mutum ya zama dole. Idan an gano manyan canje-canje na cututtukan kwayoyin halitta, ya kamata a rage yawan kashi na Liptonorm ko kuma dakatar da shan maganin gaba daya.

Kafin tsara magungunan, to, 6 da 12 makonni bayan farawa na farfaɗo, bayan kowane ƙaruwa yana ƙaruwa, haka kuma lokaci-lokaci a duk lokacin magani (alal misali, kowane watanni 6), yakamata a kula da aikin hanta. Sauyi akan aikin enzyme ana yawanci ana ganin sa cikin farkon watanni 3 na shan Liptonorm. Game da batun ƙara yawan ƙwayoyin hepatic transaminases, ya kamata marasa lafiya su kasance a ƙarƙashin kulawa ta fuskar lafiya har sai an dawo da alamun. Idan darajar alanine aminotransferase (ALT) ko aspartate aminotransferase (AST) sun fi sau 3 girma da darajar guda ɗaya don maganin hyrenplasia, ana bada shawara don rage kashi ko dakatar da magani.

Wajibi ne a kwatanta fa'idodin da ake tsammanin da kuma matsayin haɗari idan ya zama dole don rubanya Liptonorm ga mai haƙuri da ke karɓar cyclosporine, erythromycin, clarithromycin, immunosuppressants, abubuwan fibroic acid, acid nicotinic (a allurai waɗanda ke da tasirin rage kiɗa), wakilai na antifungal sune Idan akwai alamun raunin ƙwayar tsoka, rauni, ko sanyin hankali, musamman a farkon watanni na farko na jiyya ko tare da karuwa a cikin kowane kwayoyi, ya kamata a kula da yanayin mai haƙuri a hankali.

Idan akwai abubuwan haɗari don haɓakar rashin ƙarfi na ƙirar ƙarancin asali sakamakon rhabdomyolysis (alal misali, hypotension hypotension, matsanancin metabolism da rikicewar endocrine, mummunan kamuwa da cuta, rauni, babban tiyata, rashin daidaituwa na lantarki), kazalika da yanayin mummunan yanayin wanda zai iya nunawa haɓakar cutar kansa, Liptonorm dole ne a ɗan lokaci ko kuma a soke shi gaba ɗaya.

Yakamata a gargadi mara lafiya game da buƙatar tuntuɓar likita kai tsaye idan kun sami rauni ko raunin da ba a bayyana shi ba, kuma musamman idan suna tare da zazzaɓi da / ko zazzabi.

Babu wani rahoto game da mummunan tasirin Liptonorm kan iya tuki motoci da yin aikin da ke buƙatar kulawa.

Hulɗa da ƙwayoyi

Immunosuppressants, jami'in antifungal wanda aka samo daga azole, fibrates, cyclosporine, erythromycin, clarithromycin, nicotinamide suna kara yawan atorvastatin a cikin jini na jini da haɗarin haɓakar myopathy.

Hakanan ana amfani da sinadarin Liptonorm din ta hanyar masu hana aiki na CYP3A4.

Antacids yana rage yawan atorvastatin da kashi 35%, amma kada kuyi tasirin cholesterol ɗin na rashin wadataccen abinci mai yawa.

Lokacin shan Liptonorm a kashi na 80 na MG guda a lokaci guda tare da digoxin, maida hankali na ƙarshen a cikin jini yana ƙaruwa kusan 20%.

Liptonorm, wanda aka ɗauka a cikin kashi 80 na yau da kullun na 80 MG, yana ƙara yawan maganin hana haifuwa na baka wanda ya ƙunshi ethinyl estradiol ko norethidrone da 20%.

Sakamakon cututtukan cututtukan jini na haɗuwa da atorvastatin tare da colestipol ya wuce tasirin abubuwan da ke cikin kowane magani gaba ɗaya.

Game da amfani da lokaci daya na warfarin a cikin kwanakin farko na jiyya, lokacin prothrombin yana raguwa, amma bayan kwanaki 15 wannan alamar, a matsayin mai mulkin, al'ada. Saboda wannan, marasa lafiya da suke karɓar haɗuwa iri ɗaya ya kamata su sarrafa lokacin prothrombin fiye da yadda aka saba.

A lokacin jiyya, ba a ba da shawarar cinye ruwan 'ya'yan inabin ba, tunda yana iya taimakawa wajen kara yawan atorvastatin a cikin jini.