Magungunan Astrozone: umarnin don amfani

Ana samun magungunan a cikin nau'ikan allunan. Babban abu mai aiki shine pioglitazone a sashi na 30 MG. Substancesarin abubuwan da ke cikin: lactose, magnesium stearate, hyprolose, ssumum croscarmellose.

Allunan an sanya su cikin firijirin faranti na guda 10.

A cikin fakitin 1 na kwali na iya zama 3 ko 6 na waɗannan fakitin. Hakanan, ana iya samun maganin a cikin gwangwani na polymer (Allunan 30 kowane) da kwalabe iri ɗaya (guda 30).

Aikin magunguna

Clinical microbiology ya rarraba wannan magungunan azaman asalin abubuwan thiazolidinedione. A miyagun ƙwayoyi ne mai zabe agonist na takamaiman gamma masu karɓa na mutum isoenzymes.

A cikin ciwon sukari na mellitus na nau'in na biyu, magani yana rage juriya na insulin na sel hanta.

Ana iya samun su a cikin hanta, tsoka da tsoka nama. Sakamakon kunnawa masu karɓar, fassarar ƙwayoyin halitta wanda aka ƙaddara ƙwarewar insulin an daidaita shi da sauri. Hakanan suna da hannu a cikin daidaita matakan glucose na jini.

Hanyoyin haɓaka aikin metabolism kuma suna dawowa al'ada.

Matsayin juriya na kasusuwa na jiki yana raguwa, wanda ke ba da gudummawa ga saurin amfani da glucose wanda ke dogara da insulin. A wannan yanayin, matakan haemoglobin a cikin jijiyoyin jini al'ada ne.

A cikin ciwon sukari na mellitus na nau'in na biyu, jinkirin insulin na sel hanta yana raguwa sosai. Wannan yana haifar da raguwa a cikin tattarawar glucose a cikin jini, matakin insulin a cikin plasma shima yana raguwa.

Pharmacokinetics

Bayan shan kwaya akan komai a ciki, ana lura da mafi girman yawan pioglitazone a cikin jini jini bayan rabin sa'a. Idan kun sha kwayoyin bayan cin abinci, to ana samun sakamako a cikin 'yan awanni biyu. Halittuwar halitta da kuma alakanta garkuwar jini suna da yawa.

Metabolism na Pioglitazone yana faruwa a cikin hanta. Rabin rayuwar kusan 7 hours ne. Abubuwa masu aiki suna taɓarɓare ta hanyar kamfani na rayuwa tare da fitsari, bile da feces.

Abubuwan abubuwa masu aiki na Astrozone suna keɓe a cikin hanyar metabolites na asali tare da fitsari.

Contraindications

Cikakken contraindications wa yin amfani da miyagun ƙwayoyi sune:

rashin ƙarfi ga abubuwan da aka gyara,
nau'in ciwon sukari guda 1
mai ciwon sukari ketoacidosis,
rikicewar hanta da hanta,
ciki da lactation,
yara 'yan ƙasa da shekara 18,

Tare da kulawa

Ana buƙatar taka tsantsan lokacin rubuta magani ga mutanen da ke da tarihin:

kumburi
anemia
rushewa daga tsoka zuciya.

Tare da ciwon sukari

Idan kun yi amfani da magani tare da sauran wakilai na hypoglycemic ko metformin, magani ya kamata ya fara da ƙaramin sashi, i.e. sha sama da 30 MG kowace rana.

Haɗin gwiwa tare da insulin ya ƙunshi yin amfani da kashi ɗaya na Astrozone a cikin 15-30 MG a rana, kuma kashi na insulin ya kasance iri ɗaya ko sannu a hankali yana raguwa, musamman ma a yanayin hypoglycemia.

Sakamakon sakamako na Astrozone

Sanadin halayen da yawa masu illa, wanda zai iya faruwa tare da cin abinci mara kyau ko cin zarafi.

Astrozone na iya haifar da bugun zuciya.

A kusan dukkanin lokuta, marasa lafiya suna da kumburi daga sassan. Rashin gani da ido na iya haɗuwa da canji a cikin matakan glucose na jini, musamman a farkon farfaɗo. A cikin halayen da ba a san su ba, haɓakar bugun zuciya yana yiwuwa.

Tasiri kan ikon sarrafa abubuwan inji

Domin sakamakon amfanin wannan magani, haɓakar haɓakawar jini zai yuwu, tare da tsananin zafin rai da haushi, yakamata ku ƙi fitar da mota da sarrafa sauran hanyoyin da ake fama da su. Wannan yanayin na iya shafar yawan maida hankali da maida hankali.

Ya kamata ku ƙi fitar da mota yayin jiyya tare da Astrozone.

Umarni na musamman

Tare da taka tsantsan, an wajabta magunguna ga marasa lafiya da haɗarin cutar edema, da kuma a cikin tiyata (kafin tiyata mai zuwa). Cutar sankarar mahaifa na iya haɓaka (raguwa a hankali na haemoglobin mafi yawanci ana danganta shi da hauhawar haɓakar ƙwayar jini a cikin jiragen.)

Kulawa da matakin hypoglycemia ya zama dole lokacin amfani da magani a hade tare da ketoconazole.

Yi amfani da lokacin daukar ciki da lactation

Shan kwalaben kwalaji ne yayin daukar ciki da yayin shayarwa. Kodayake an tabbatar da cewa abu mai aiki ba shi da wani tasirin teratogenic akan haihuwa, yana da kyau mu watsar da irin wannan jiyya yayin shirin daukar ciki.

Shan allunan 'Astrozone' an hana daukar ciki yayin shayarwa.

Yawan adadin kumburin Astrozone

Babu wasu maganganu na yawan yawan zubar da jini ta Astrozone da aka tantance a baya. Idan kun bazata kuna shan babban magani, ƙwayar cuta babba wacce ake bayyana ta rashin lafiyar dyspeptic da haɓakar haɓakawa na iya haɗuwa.

Game da bayyanar cututtuka na halayyar ƙwayar cuta, ya zama dole a yi maganin tiyata har sai an kawar da duk abubuwan da ba a sani ba.

Idan hypoglycemia ya fara haɓaka, ana iya buƙatar maganin detoxification da hemodialysis.

Idan hypoglycemia ya fara da wuce haddi na Astrozone, ana iya buƙatar hemodialysis.

Yin hulɗa tare da wasu kwayoyi

Lokacin amfani dashi a hade tare da maganin hana haihuwa, ana lura da raguwa mai ƙarfi a cikin metabolites na abu mai aiki. Sabili da haka, an rage tasirin amfani da magungunan hana haihuwa.

Tsarin aikin pioglitazone metabolism a cikin hanta kusan an katange gaba ɗaya lokacin da ake amfani dashi tare da ketoconazole.

Amfani da barasa

Ba za ku iya aiwatar da aikin likita tare da magani ku sha barasa ba. Wannan na iya haifar da karuwar sakamako akan tsarin mai juyayi. Hadarin da ke tattare da haifar da faruwar cutar dyspeptik na ƙaruwa. Kwayar cutar maye

Akwai da yawa analogues na Astrozone wadanda suke kama da su dangane da sinadaran aiki da warkewar cutar:

Diab Norm
Diaglitazone,
Amalvia
Pioglar
Pioglite
Piouno

Ranar karewa

Ba'a wuce shekaru 2 ba daga ranar da aka ƙera da aka nuna akan kunshin. Kada kayi amfani da ranar karewa.

Ana amfani da analog na Astrozone - ba za a iya amfani da miyagun ƙwayoyi na Piuno a ƙarshen ranar karewa ba.

1 ml abun da ke ciki

Meloxicam - 6.00 mg

Mahalarta: meglumine - 3.75 mg, poloxamer 188 - 50.00 mg, tetrahydrofurfuril macrogol (glycofurol) - 100,00 mg, glycine - 5.00 mg, sodium chloride - 3.00 mg, 1 M sodium hydroxide bayani - zuwa pH na 8.2-8.9, ruwa don yin allura - har zuwa 1 ml.

Poaya daga cikin ampoule (2.5 ml) ya ƙunshi 15 mg na meloxicam.

bayyananne ruwa mai ruwan kore-rawaya.

Nazarin Astrozone

Oleg, ɗan shekara 42, Penza

Na daɗe ina fama da ciwon sukari na 2. An tsara magunguna da yawa, amma sakamakon su bai wuce muddin muna so ba. Kuma ba zai yiwu a gare ni in yi allura ba koyaushe. Sannan likita ya shawarce ni in sha kwayoyin Astrozone. Na ji sakamakon su da sauri isa. Yanayin gaba daya ya inganta nan da nan. Matakan jini na jini ya koma kamar yadda yake a dai dai 'yan makwanni biyu. A wannan yanayin, 1 kwamfutar hannu 1 isa ga dukan rana. Na gamsu da sakamakon jiyya.

Andrey, shekara 50, Saratov

Likita ya ba da allunan Astrozone a 15 MG kowace rana saboda gaskiyar cewa a farkon magani akwai gwajin hanta mara kyau. Amma irin wannan maganin bai taimaka ba. Likita ya ba da shawarar kara yawan zuwa kashi 30 a kowace rana, wanda ya ba da sakamako nan da nan. Dangane da bincike, manunin glucose ya ragu. Sakamakon ya dauki tsawon lokaci har sai an soke maganin. Lokacin da gwaje-gwajen suka fara tabarbarewa, likita ya ba da izinin suturar kiyayewa na 15 a kowace rana. Kusan sukari na riƙe kusan matakin guda ɗaya yanzu kusan yanzu, saboda haka ba zan iya faɗi mummunan abu ba game da miyagun ƙwayoyi.

Peter, dan shekara 47, Rostov-on-Don

Magungunan bai dace ba. Ban ji wani sakamako ba daga farkon matakin 15 mg. Dangane da sakamakon binciken, babu kuma wasu canje-canje na musamman. Da zaran an kara kashi 30 zuwa 30, sai yanayin ya tsananta nan take. Cigaba da rashin ƙarfi na haɓaka, cututtukan da suke ƙasƙantar da ni kawai. Dole ne in maye gurbin miyagun ƙwayoyi.

Nau'i na saki, abun da ke ciki

Ana samun magungunan a cikin hanyar samar da mafita don gudanarwar intramuscular. Maganin shine meloxicam azaman aiki mai aiki. 1 ml na mafita ya ƙunshi 6 mg na meloxicam.

Kamar yadda abubuwa masu taimako sune glycine, sodium hydroxide, glycofurol, chloride sodium, ruwa don yin allura.

Sakamakon sakamako na zaɓaɓɓen ƙwayar cuta, abu mai aiki na ƙwayar ya ba da gudummawa ga haɓakar cututtukan erosive na ciki da duodenum.

Hanyar aikace-aikacen, sashi

An yarda da maganin ta hanyar jijiya a cikin 'yan kwanakin farko na magani. A nan gaba, ana bada shawarar canzawa zuwa maganin baka na maganin (Allunan).

Shawarar da aka bada shawarar yau da kullun shine daga 7.5 zuwa 15 MG. Matsakaicin ƙwaƙwalwa da tsawon maganin yana likita ne ƙaddara, la'akari da alamun bayyanar cutar da halayen mutum na jikin mai haƙuri.

Marasa lafiya waɗanda ke kan cututtukan hemodialysis kuma suna da tarihin mummunan rauni na aikin koda bai kamata ya wuce matsakaicin yawan maganin yau da kullun na 7.5 mg ba.

Ba a da shawarar Arthrosan a haɗu a cikin sirinji guda tare da kwayoyi na sauran ƙungiyoyi. Ba a yarda da gudanar da magungunan ƙwayar cuta ba.

Yin hulɗa tare da wasu rukuni na kwayoyi

Dole ne a yi amfani da wannan miyagun ƙwayoyi tare da taka tsantsan lokacin amfani da su a lokaci guda tare da kwayoyi daga rukuni na anticoagulants (Warfarin), jami'in antiplatelet (Plavix, Clopidogrel), barasa, corticosteroids (Prednisolone), Fluoxetine, Paroxetine.

Bai kamata a yi amfani da Arthrosan ba tare da haɗin gwiwa tare da wasu kwayoyi daga ƙungiyar magungunan anti-mai kumburi.

Tare da amfani da lokaci daya tare da diuretics, haɗarin haɓaka gazawar haɓaka ƙima yana ƙaruwa.

Tare da amfani lokaci guda tare da kwayoyi daga cutar hawan jini, tasirin su na iya raguwa.

Idan aka haɗu da bitamin K, heparin, serotonin reuptake inhibitors, da fibrinolytics, haɗarin zubar jini yana ƙaruwa.

Guidancearin jagora

Tare da haɓaka halayen jiki wanda ke nuna ƙetarewar aiki na ƙodan na al'ada (itching da yellowness na fata, amai, fitsari duhu, jin zafi a cikin ciki), ya kamata a dakatar da amfani da miyagun ƙwayoyi nan da nan kuma a nemi likita.

Arthrosan na iya rufe alamun bayyanar cututtuka.

Ba za a iya amfani da wannan magani azaman prophylaxis na thrombosis ba, duk da ikonta na rage haɗuwar platelet.

Analogs na injections Arthrosan

Magunguna masu zuwa sune analogues na shirye-shiryen Arthrosan: Melox, Amelotex, Mirlox, Mesipol, Movasin, Movalis. Idan kuna buƙatar maye gurbin maganin, ya kamata ku fara tuntuɓarku da likitan ku.

Ya kamata a aiwatar da adana allura Arthrosan a wuri mai duhu, kariya daga hasken rana kai tsaye, nesa da yara. Zafin ajiya - ba fiye da digiri 25 ba.

Magunguna da magunguna

Abu mai aiki meloxicam- mai samo asali oksikama. Yana da tasirin anti-mai kumburi, yana toshe hanyoyinkaruwai da enzyme chicooxygenase-2wanda ke shiga cikin sake zagayowar arachidonic acid.

A ƙarƙashin rinjayar meloxicam, aiki masu shiga tsakani da kuma permeability jijiyoyin bugun jiniraguwa sosai, braking yana faruwa halayen tare da free radicals. Anesthesia yana faruwa ne saboda raguwa a cikin ayyukan haɗin gwiwar prostaglantins da jijiya karshen.

An sami cikakkiyar daidaitaccen maida hankali tsakanin kwana uku zuwa biyar. Yana ɗaure da kyau ga ƙwayoyin plasma (99% da sama). Mezazzabia cikin hanta, samarda metabolites 4. Ba su taka rawa a cikin hanyoyin harhada magunguna. Ana amfani da kwayoyin daskarewa cikin feces da fitsari a cikin awanni 15 zuwa 20.

Alamu don amfani

A cikin maganin monotherapy a cikin marasa lafiya (musamman ma wadanda suke da kiba) wadanda basa samun karfin glycemic ta hanyar biye da tsarin abinci da kuma motsa jiki da kuma wanda aka sarrafa tsarin metformin,

a hade tare da metformin a cikin marasa lafiya (musamman kiba) waɗanda ba su cin nasarar sarrafa glycemic a bango daga matsakaiciyar ƙimar maganin metformin,

a hade tare da abubuwan da ake amfani dasu na sulfonylurea a cikin marassa lafiya wadanda basu cimma karfin glycemic iko a bango na matsakaiciyar jinkirin magungunan maganin sulfonylurea wanda kuma shine tsarin metformin wanda yake tazara,

a hade tare da abubuwan da ake amfani da su na metformin da abubuwan sulfonylurea a cikin marasa lafiya (musamman ma wadanda suka yi kiba) wadanda ba su cimma nasarar glycemic a yayin hada magunguna tare da abubuwan da ake amfani da su na metformin da kuma abubuwan da suka samo asali na sulfonylurea,

a hade tare da insulin a cikin marasa lafiya waɗanda ba su cimma nasarar glycemic iko ba yayin amfani da insulin kuma ga waɗanda aka sarrafa tsarin metformin.

Umarnin don amfani da Arthrosan (Hanyar da sashi)

Ana ɗaukar allunan sau ɗaya a rana, tare da abinci, ana wanka da ruwa. Thewarin da aka bada shawarar yau da kullun sun kasance daga 7.5 MG zuwa 15 MG, ya danganta da tsananin ciwo mai raunin ciwo da kuma cutar.

Idan ba za a sha maganin ba bakana iya nada allurar ciki.

Inje na Arthrosan, umarnin don amfani

An wajabta allurar arthrosan don tsananin raɗaɗi a cikin kwanakin farko na rashin lafiya. Magungunan ƙwayoyi ta haifar intramuscularlyzurfi a cikin masana'anta. Adadin yau da kullun yana daga 7.5 zuwa 15 MG, kuma ana fara amfani da magani tare da ƙananan allurai kuma yana ƙaruwa har sai an sami sakamako mai so.

Karka wuce shawarar da aka bayar da shawarar, watakila ka iya haɗarin haɗarin sakamako masu illa.

Kayan magunguna

Pharmacodynamics

Meloxicam magani ne mai hana steroidal anti-inflammatory (NSAID), yana nufin asalin tushen enolic acid kuma yana da anti-inflammatory, analgesic and antipyretic sakamako. An kafa tasirin anti-mai kumburi da tasirin zartarwa a duk matakan kirki na kumburi. Hanyar aiki na meloxicam shine ikonta na hana rikitarwar ayyukan prostaglandins, matsakanci masu sanannen matsakaici. A cikin vivo meloxicam yana hana kwayar cutar prostaglandin a wurin da kumburi har zuwa mafi girma fiye da na mucosa na ciki ko kodan.

Wadannan bambance-bambance suna da alaƙa da ƙarin zaɓi mai hana cyclooxygenase-2 (COX-2) idan aka kwatanta da cyclooxygenase-1 (COX-1). An yi imani cewa hanawa na COX-2 yana ba da tasirin warkewar cutar NSAIDs, yayin da hanawa na kullun COX-1 isoenzyme na iya kasancewa da alhakin sakamako masu illa daga ciki da kodan. An tabbatar da zaɓi na meloxicam dangane da COX-2 a cikin tsarin gwaji daban-daban, duka biyu a cikin vitro da vivo. Selectarfin zaɓin mai amfani da ƙwayar cuta mai guba ta hana COX-2 nuna lokacin amfani da in vitro dukkanin jini a matsayin tsarin gwaji.

An gano cewa meloxicam (a allurai na 7.5 da 15 mg) mafi karfi da aka hana COX-2, yana yin tasiri mai girma na hana ci gaba a cikin aikin prostaglandin E2 wanda ke motsa shi ta lipopolysaccharide (amsawar da aka sarrafa ta COX-2) fiye da samar da thromboxane, wanda ke shiga cikin coagulation jini (dauki da aka sarrafa ta hanyar COX-1).Wadannan illolin sunada dogaro. Nazarin Ex vivo ya nuna cewa meloxicam (a allurai na 7.5 MG da 15 MG) ba shi da wani tasiri akan tarawar platelet da lokacin zubar jini.

A cikin nazarin asibiti, sakamako masu illa daga jijiyar gastrointestinal (GIT) gabaɗaya sun faɗi ƙasa yayin shan meloxicam 7.5 da 15 MG fiye da lokacin ɗaukar sauran NSAIDs wanda aka kwatanta. Wannan bambance-bambance a cikin yawan tasirin sakamako daga cututtukan gastrointestinal shine galibi saboda gaskiyar cewa lokacin shan meloxicam, yawanci ba a lura da abubuwan mamaki kamar dyspepsia, vomiting, tashin zuciya, ciwon ciki. Mitar sauye-sauye a cikin jijiyoyin ciki na sama, da ƙaiƙayi da zub da jini, waɗanda ke alaƙa da amfani da meloxicam, ya yi ƙasa kaɗan kuma ya dogara da yawan ƙwayoyi.

Pharmacokinetics

Meloxicam yana kasancewa cikakke bayan aikin intramuscular. Dangane da bioavailability idan aka kwatanta da na bioavailability na baka kusan 100%. Saboda haka, lokacin da ake sauya sheka daga allurar zuwa na zabi na zabi na kashi ba lallai bane. Bayan gudanar da 15 MG na miyagun ƙwayoyi intramuscularly, mafi girman ƙwayar plasma maida hankali (kimanin 1.6 - 1.8 μg / ml) an kai shi cikin kimanin minti 60 - 96.

Meloxicam yana ɗaure sosai ga furotin plasma, akasarinsu tare da albumin (99%). Penetrates cikin ruwa mai narkewa, maida hankali ne a cikin ruwa shine kusan kashi 50% na yawan ƙwayar plasma. Volumearancin rarraba ƙasa yayi ƙasa, kusan lita 11. Bambancin daidaikun mutane shine 7-20%.

Meloxicam ya kusan kusan metabolized a cikin hanta tare da ƙirƙirar 4 magunguna waɗanda ba su da magani. Babban metabolite, 5-carboxy-meloxicam (60% na kashi), an samo shi ne ta hanyar hadawan abu da iskar shaka a cikin metabolite na tsakiya, 5-hydroxymethylmeloxicam, wanda shima an cire shi, amma har zuwa mafi ƙarancin (9% na kashi). Nazarin cikin vitro ya nuna cewa CYP2C9 isoenzyme yana taka muhimmiyar rawa a cikin wannan canji na rayuwa, kuma CenP3A4 isoenzyme yana taka rawa sosai. A cikin samuwar wasu metabolites guda biyu (hada, bi da bi, 16% da 4% na kashi na miyagun ƙwayoyi), peroxidase ya ƙunshi, ayyukan da tabbas da bambanta daban-daban. Kiwo

An cire shi daidai ta hanjin ciki da kodan, galibi ta hanyar metabolites. A cikin hanyar da ba ta canzawa, kasa da 5% na adadin yau da kullun an keɓe shi da feces, a cikin fitsari a cikin hanyar da ba ta canzawa, ana samun miyagun ƙwayoyi ne kawai cikin adadin gano. Matsakaicin rabin rabin meloilyam ya bambanta daga awanni 13 zuwa 25. Saddamar da aikin plasma aƙalla 7-12 ml / min bayan amfani guda. Meloxicam yana nuna magunguna masu layi a cikin allurai na 7.5-15 mg tare da gudanarwar intramuscular.

Rashin hanta da / ko aikin koda

Rashin aikin hanta, har da gazawar ƙarancin koda, baya tasiri sosai kan magunguna na meloxicam. Yawan kawar da meloxicam daga jiki yana da matukar girma a cikin marasa lafiya tare da gazawar matsakaiciyar matsakaici. Meloxicam yana da ƙarancin ɗaure wa furotin plasma a cikin marasa lafiya da ƙarshen ƙarancin renal matakin. A cikin gazawar tashar ƙarancin tasirin, haɓakawa da yawa na rarraba zai iya haifar da mafi girman yawan ƙwayoyin cuta mai kyauta, don haka a cikin waɗannan marasa lafiya kashi ɗaya na yau da kullun kada ya wuce 7.5 MG.

Tsofaffi marasa lafiya idan aka kwatanta da matasa marasa lafiya suna da irin wannan tsarin samar da magunguna. A cikin marasa lafiya tsofaffi, matsakaicin yardawar plasma yayin yanayin daidaitawar magungunan ƙwaƙwalwar ƙwaƙwalwa ya ɗan ragu fiye da na marasa lafiya matasa. Mace tsofaffi suna da darajar darajar AUC mafi girma (yanki a ƙarƙashin tsarin lokacin maida hankali) da tsawon rayuwar rabin kawar, idan aka kwatanta da matasa marasa lafiya na duka biyun.

Sashi da gudanarwa

Osteoarthritis tare da ciwo: 7.5 MG kowace rana. Idan ya cancanta, ana iya ƙara wannan kashi zuwa 15 MG kowace rana.

Rheumatoid amosanin gabbai: 15 MG kowace rana. Dangane da tasirin warkewa, ana iya rage wannan kashi zuwa 7.5 MG kowace rana.

Spinalylitis na rashin damuwa: 15 MG kowace rana. Dangane da tasirin warkewa, ana iya rage wannan kashi zuwa 7.5 MG kowace rana.

A cikin marasa lafiya da haɓakar haɗarin halayen masu illa (tarihin cututtukan ƙwayar jijiyoyin ƙwayar cuta, kasancewar abubuwan haɗari don cutar cututtukan zuciya), an ba da shawarar fara magani tare da kashi 7.5 MG kowace rana (duba sashe "Umarnin na Musamman"). A cikin marasa lafiya tare da gazawar lalataccen ƙwayar cuta wanda ke fuskantar hemodialysis, kashi bai kamata ya wuce 7.5 MG kowace rana ba.

Janar shawarwari

Tunda yiwuwar haɗarin halayen cutarwa ya dogara da kashi da tsawon lokacin magani, mafi ƙarancin yiwuwar amfani da lokacin amfani yakamata ayi amfani dashi. Matsakaicin da aka bayar da shawarar kullun shine 15 MG.

Amfani mai hade

Bai kamata ku yi amfani da miyagun ƙwayoyi lokaci guda tare da sauran NSAIDs ba. Jimlar maganin yau da kullun na Arthrosan® da ake amfani da shi ta fannoni daban-daban bai kamata ya wuce 15 MG ba.

An nuna aikin kulawa da magungunan ƙwayar cuta a cikin daysan kwanakin farko na far. Ana ci gaba da magani tare da yin amfani da nau'ikan sashi na maganin. Adadin da aka ba da shawarar shi ne 7.5 MG ko 15 MG 1 sau ɗaya kowace rana, ya danganta da tsananin zafin da tsananin zafin kumburin.

Ana gudanar da maganin ta hanyar allura mai zurfin ciki.

Ba za a iya gudanar da maganin ba a cikin zuciya.

Ganin ba zai yiwu da rashin daidaituwa ba na Arthrosan, mafita don gudanar da intramuscular kada a haɗu a cikin sirinji guda tare da sauran kwayoyi.

Side sakamako

Abubuwan da ke haifar da sakamako an bayyana su a ƙasa, dangantakar da ke tattare da amfani da meloxicam an dauke ta yiwu.

Abubuwan da ke tattare da gefen da aka yi rikodin su yayin amfani da bayan-cinyewa, ana yin alaƙar dangantakar da tare da amfani da maganin sautsi kamar yadda zai yiwu, alama da *.

Ana amfani da waɗannan nau'ikan rukuni cikin azuzuwan kayan aikin gwargwadon yawan tasirin sakamako:

sau da yawa (> 1/10),
sau da yawa (> 1/100. 1 / 1,000. 1 / 10,000. Barkewar damuwa daga jini da tsarin lymphatic:

Da wuya - leukopenia, thrombocytopenia, canje-canje a cikin adadin ƙwayoyin jini, gami da canje-canje a cikin tsarin leukocyte.

Rashin rigakafin tsarin cuta:

A lokaci-lokaci, wasu nau'in tashin hankali na kai tsaye *, Ba a samo shi ba - alamar anaphylactic shock *, halayen anaphylactoid. Rashin hankalin kwakwalwa: Da wuya - canje-canje yanayi

Ba a kafa ba - rikicewa *, disorientation *. Rashin hankali daga tsarin juyayi: Sau da yawa - ciwon kai, A lokaci-lokaci - tsananin farin ciki, bacci.

Take hakkin gabobi na gani, ji da cutawar labyrinth: A lokaci-lokaci - vertigo,

Da wuya - conjunctivitis *, raunin gani, gami da hangen nesa mai haske *, tinnitus. Take hakkin zuciya da jijiyoyin jini:

A lokaci-lokaci - karuwa a cikin karfin jini, jin "hawan jini" a fuska, Da wuya - bugun zuciya.

Take hakkin tsarin na numfashi:

Da wuya - fuka-fuka-fuka-fuka a cikin marasa lafiya rashin lafiyar acetylsalicylic acid da sauran NSAIDs.

Laifin cutar e / gastrointestinal fili: Sau da yawa - zafin ciki, dyspepsia, zawo, tashin zuciya, amai,

Akai-akai - latent ko kuma na fili jijiyoyin jini, gastritis *, stomatitis, maƙarƙashiya, bloating, belching, Da wuya - gastroduodenal ulcers, colitis, esophagitis, Da wuya - perforation na gastrointestinal fili. Take hakkin hanta da kuma hanjin biliary:

Lokaci-akai - canje-canje na lokaci-lokaci a cikin ayyukan aikin hanta (alal misali, ƙara yawan aiki na transaminases ko bilirubin), Da wuya - hepatitis *.

Rashin daidaituwa daga fata da kasusuwa na katako: Infarancin lokaci - angiotek *, itching, fatar fata,

Da alama mai guba mai guba *, Stevens-Johnson ciwo *, urticaria,

Da wuya sosai - ƙarancin cuta mai narkewa *, erythema multiforme *, Ba a samo shi ba - hotoensitivity.

Take hakkin yara da hanjin urinary:

A lokaci-lokaci - canje-canje a cikin alamomi na aikin koda (karuwa a cikin creatinine da / ko urea a cikin jini), rikicewar urination, gami da matsanancin urinary riƙewa *,

Da wuya sosai - ƙarancin na koda!

Take hakkin gabobi da mammary gland:

Akai-akai - marigayi ovulation *,

Ba a kafa ba - rashin haihuwa a cikin mata *.

Janar cuta da rikice-rikice a wurin yin allura:

Sau da yawa - zafi da kumburi a wurin allurar,

Yin amfani da haɗin gwiwa tare da kwayoyi waɗanda ke hana haɓakar ƙashi (misali, methotrexate) na iya haifar da cytopenia.

Zazzabin ciwan ciki, ulcer, ko karkatarwa na iya zama mai mutuwa.

Amma ga sauran NSAIDs, ba su ware yiwuwar bayyanar cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, glomerulonephritis, renal medullary necrosis, nephrotic syndrome.

Yin hulɗa tare da wasu kwayoyi

Sauran masu hana prostaglandin kira, ciki har da glucocorticoids da salicylates, yin amfani da concoitant tare da meloxicam yana kara haɗarin rauni a cikin jijiyoyin ciki da zub da jini na ciki (saboda yanayin aiki). Yin amfani da ma'amala tare da sauran NSAIDs ba da shawarar ba. Anticoagulants don maganin baka, heparin don amfani da tsari, wakilai na thrombolytic - gudanarwa na lokaci daya tare da meloxicam yana ƙara haɗarin zubar jini. Idan aka yi amfani da shi a lokaci daya, saka idanu sosai kan tsarin coagulation na jini ya zama dole.

Magungunan rigakafin ƙwayar cuta, magungunan antirolet, serotonin reuptake inhibitors, yin amfani da concoitant tare da meloxicam yana ƙara haɗarin zub da jini saboda hana aikin platelet. Idan aka yi amfani da shi a lokaci daya, saka idanu sosai kan tsarin coagulation na jini ya zama dole.

Shirye-shiryen Lithium - NSAIDs sun haɓaka matakin ƙwayar lithium a cikin plasma ta rage rage farincinta da kodan. Yin amfani da karin ruwa tare da shirye-shiryen lithium lokaci guda. Idan ya cancanta, yin amfani da lokaci guda na shawarar da aka sanya a hankali a kula da maida hankali kan yawan lithium a cikin plasma a duk lokacin shirye-shiryen lithium.

Methotrexate - NSAIDs suna rage ɓarin ƙwayar methotrexate ta kodan, don haka yana ƙaruwa da yawa a cikin ƙwayar plasma. Ba a ba da shawarar yin amfani da meloxicam da methotrexate (a yawancin kashi 15 na mako ɗaya). Game da amfani da lokaci daya, saka idanu a hankali kan aikin koda da ƙididdigar jini wajibi ne. Meloxicam na iya haɓaka guba na ƙwaƙwalwar ƙwayar cuta na methotrexate, musamman a cikin marasa lafiya da ke fama da rauni na aikin koda.

Maganin hana daukar ciki - akwai wata shaida da ke nuna cewa NSAIDs na iya rage tasirin na'urorin intrauterine, amma ba a tabbatar da wannan ba.

Diuretics - yin amfani da NSAIDs dangane da zubar da ruwa na marasa lafiya yana haɗuwa tare da haɗarin lalacewa mai ƙoshin koda.

Jami'an antihypertensive (beta-blockers, angiotensin-canza enzyme inhibitors, vasodilators, diuretics). NSAIDs suna rage tasirin magungunan antihypertensive, saboda hanawa na prostaglandins tare da kaddarorin vasodilating.

Angiotensin II antagonists, da angiotensin-canza enzyme inhibitors lokacin da aka yi amfani dasu tare da NSAIDs, suna ƙaruwa da raguwa a cikin ɗaukar hoto, wanda zai iya haifar da haɓaka gazawar ƙirar ƙarancin ƙasa, musamman a cikin marasa lafiya da ke fama da rauni na aikin haya.

Colestyramine, yana ɗaure wa meloxicam a cikin jijiyar ciki, yana kaiwa ga saurin ta a hankali.

Pemetrexed - tare da amfani da na yau da kullun tare da amfani da gurɗa tare da pemetrexed a cikin marasa lafiya tare da sharewa daga 45 zuwa 79 ml / min, ya kamata a dakatar da meloxicam kwanaki biyar kafin farkon pemetrexed kuma ana iya sake komawa kwanaki 2 bayan ƙarshen maganin. Idan akwai buƙatar yin amfani da haɗakar maganin salamamai da pemetrexed, to irin waɗannan marasa lafiya ya kamata a sa ido sosai, musamman game da myelosuppression da faruwar sakamako masu illa daga ƙwayar gastrointestinal. A cikin marasa lafiya tare da keɓantaccen keɓancewar kasa da milimita 45 / min, ba a bada shawarar yin amfani da karin fata tare da pemetrexed.

NSAIDs, yin aiki akan prostaglandins na renal, na iya haɓaka nephrotoxicity na cyclosporin.

Lokacin amfani dashi cikin haɗuwa tare da magungunan meloxicam waɗanda ke da sananniyar ikon hana CYP 2C9 da / ko CYP ZA4 (ko kuma waɗannan enzymes suna metabolized), irin su sulfonylureas ko probenecid, yiwuwar hulɗa da pharmacokinetic ya kamata a la'akari dashi. Lokacin da aka haɗu da wakilai na maganin antidiabetic don maganin bakin magana (alal misali, abubuwan da suka samo asali na sulfonylurea, nateglinide), hulɗar da ke shiga ta hanyar CYP 2C9 mai yiwuwa ne, wanda zai haifar da haɓakar haɗuwa da waɗannan magungunan da meloxicam a cikin jini. Marasa lafiya da ke shan meloxicam tare da maganin sulfonylurea ko shirye-shiryen kwayar halitta ya kamata su lura da sukarin jininsu a hankali saboda yuwuwar cutar sikila.

Ta hanyar amfani da antacids, cimetidine, digoxin da furosemide, ba a gano mahimmancin ma'amala da magunguna.

Sashi da gudanarwa

Ana amfani da allurar tare da Arthrosan ne kawai a cikin kwanakin farko na jiyya sau ɗaya a rana, a 7.5 ko 15 ml, bayan wannan ana ci gaba da magani tare da allunan. Sakamakon haɗarin sakamako masu illa, an bada shawarar yin amfani da miyagun ƙwayoyi a cikin mafi ƙarancin magunguna. Ya kamata a gudanar da allurar tare da Arthrosan kawai intramuscularly kuma ba a ba da shawarar haɗa magungunan a cikin sirinji ɗaya tare da wasu kwayoyi.

Ana ɗaukar allunan Arthrosan sau ɗaya a rana, zai fi dacewa da abinci. Matsakaicin adadin yau da kullun shine 15 MG. Sashi ya dogara da cutar:

Tare da osteoarthrosis, ɗauki kwamfutar hannu guda ɗaya na Artrozan 7.5 MG, a cikin rashin sakamako, ana iya ninka kashi biyu,
Yankin da aka ba da shawarar yau da kullun don maganin arthritis shine 15 MG, bayan ingantawa, ana iya rage kashi zuwa 7.5 MG kowace rana,
Tare da ankylosing spondylitis, ɗauki kwamfutar hannu guda ɗaya na Arthrosan 15 MG kowace rana.

Dangane da umarnin ga Arthrosan, idan akwai yawan wuce haddi, zafin jijiyoyin jiki, tabarbarewar tunani, tashin zuciya, kamawar numfashi, amai, m na koda da kuma rashin lafiyar hepatic, asystole na iya faruwa.

Yakamata a yi taka tsantsan yayin amfani da Arthrosan tare da magungunan antihypertensive, methotrexate, diuretics, cyclosporine, shirye-shiryen lithium da wasu magunguna. Hadarin zub da jini daga cikin gastrointestinal fili yana ƙaruwa tare da amfani da Arthrosan lokaci guda tare da sauran magungunan anti-steroidal anti-inflammatory, gami da acetylsalicylic acid.

Ana amfani da Arthrosan tare da taka tsantsan yayin lalacewa da jijiyoyin raunuka na hanji a cikin anamnesis da kuma a cikin tsufa.

Ra'ayoyi game da Arthrosan

Nazarin game da injections na Arthrosan suna da kyau. A miyagun ƙwayoyi ne in mun gwada da sauki da kuma sosai tasiri. Mutane da yawa sun taimaka wajen jimre da ciwo tare da cututtukan haɗin gwiwa daban-daban. Shan kwayoyin suna da sakamako iri iri kamar inje. Daga cikin minuses, ana lura da sakamako masu illa a cikin nau'in ciwon kai, raɗaɗin ciki da tsananin ciki, amma wannan yakan faru sau da yawa.