Yaya za a yi amfani da miyagun ƙwayoyi Neyrolipon?

Parenteral, a cikin 300 da 600 MG: masu ciwon sukari da polyneuropathy na giya.

A cikin 12 da 25 MG: hanta mai ƙiba, cirrhosis, hepatitis na kullum, hepatitis A, maye (haɗe da salts na baƙin ƙarfe mai nauyi), guba tare da toadstool mai ratsa jiki, hyperlipidemia (ciki har da haɓakar hanji na atherosclerosis - magani da rigakafin )

Side effects

Daga narkewa: yayin da aka sha shi a baki - tashin zuciya, amai, ciwon ciki, zawo.

Allergic halayen: fatar fata, itching, urticaria, anaphylactic shock.

Sauran: ciwon kai, gurguntar glucose metabolism (hypoglycemia), tare da saurin gudanarwa na iv - jinkiri na gajeren lokaci ko wahalar numfashi, karuwar matsin lamba na intracranial, tashin zuciya, diplopia, ganuwar basur a cikin fata da mucous membranes da halin zub da jini (saboda raunin aikin platelet. )

Kawasaki Neurolipon (Neurolipon)

Umarnin don amfanin likita

• Alamu don amfani
• Fom ɗin saki
• Pharmacodynamics na miyagun ƙwayoyi
• Pharmacokinetics na miyagun ƙwayoyi
• Yi amfani yayin daukar ciki
• Contraindications
• Side effects
• Sashi da gudanarwa
• Yawan abin sama da ya kamata
• Haɗi tare da wasu kwayoyi
• Kariya don amfani
• Yanayin ajiya
• Ranar karewa

Tsarin ilimin rayuwa (ICD-10)

Sashi da gudanarwa

Cikin / in. Manya a kashi na 600 MG / rana. Shigar da hankali - ba fiye da 50 mg / min na thioctic acid (1.7 ml na bayani don jiko).

Ya kamata a gudanar da miyagun ƙwayoyi ta hanyar jiko tare da 0.9% sodium chloride bayani sau ɗaya a rana (600% na miyagun ƙwayoyi an haɗu da 50-250 ml na 0.9% sodium chloride bayani). A cikin lokuta masu tsauri, har zuwa 1200 MG ana iya gudanar da shi. Ya kamata a kare hanyoyin jiko daga haske ta rufe su da garkuwar wuta.

Aikin ne daga sati 2 zuwa hudu. Bayan haka, suna canzawa zuwa jiyya na kulawa tare da siffofin sashi na maganin thioctic don gudanar da maganin baka a cikin kashi 300-600 mg / rana don watanni 1-3. Don inganta tasirin magani, ana bada shawarar yin aikin jiyya tare da ƙwayar Neyrolipon sau 2 a shekara.

Ba a tabbatar da inganci da amincin magani a cikin yara ba.

Fom ɗin saki

Sanya hankali don bayani don jiko, 30 MG / ml. A cikin gilashin ampoules mai launin ruwan kasa, tare da zoben hutu ko aya mai fashewa, 10 ko 20 ml.

5 ko 10 am. tare tare da jakar baƙar fata fim na PE ko ba tare da shi ba a cikin kwali na kwali mai layin wuta.

5 amp. a cikin silar fitar da fim ɗin PVC. 1 ko 2 bl. tare da ampoules tare da jakar baƙar fata fim na PE ko ba tare da shi ba a cikin fakitin kwali.

Mai masana'anta

PJSC "Farmak". 04080, Ukraine, Kiev, st. Frunze, 63.

Tel./fax: (8-10-38-044) 417-10-55, 417-60-49.

Kungiyar ta yarda da da'awar daga masu amfani: ofishin wakilin Farmak JSC na jama'a a Rasha: 121357, Moscow, ul. Kutuzovsky Prospect, 65.

Waya: (495) 440-07-58, (495) 440-34-45.

Contraindications

Hypersensitivity ga abubuwan da ke cikin miyagun ƙwayoyi.

Ciki, lokacin shayarwa (gogewa tare da maganin bai isa ba).

Yaran da ke ƙasa da shekara 18 (ba a kafa ingantaccen aiki da amincin amfani ba).

Additionalarin ƙarin contraindication don amfani da Neurolipon a cikin nau'i na capsules shine rashin haƙuri na galactose, ƙarancin lactase ko glucose-galactose malabsorption.

Pharmacodynamics

Abubuwan da ke aiki da Neyrolipon - thioctic acid - an haɗu da shi kai tsaye a cikin jiki kuma yana aiki a matsayin coenzyme a cikin tsarin narkewar ƙwayoyin cuta na α-ketonic acid. An taka muhimmiyar rawa ta thioctic acid a cikin metabolism na makamashi na sel. A cikin nau'in lipoamide, acid yana aiki a matsayin mahimmancin haɗin abubuwan hadaddun enzyme masu yawa, waɗanda sune abubuwan da ke haifar da ragewar α-keto acid na zagayen Krebs.

Neyrolipon yana da antitoxic da antioxidant Properties, a Bugu da kari, thioctic acid na iya sake dawo da sauran maganin antioxidants, alal misali, a cikin ciwon sukari na mellitus, rage juriya na insulin da rage jinkirin ci gaban neuropathy na yanki.

Acid na Thioctic yana taimaka wajen rage glucose din plasma da kuma tara glycogen a cikin hanta. Yana shafar metabolism na cholesterol, yana shiga cikin tsarin metabolism na fats da carbohydrates, yana inganta aikin hanta saboda maganin hepatoprotective, antioxidant da ingancin detoxification.

Pharmacokinetics

Halayen Pharmacokinetic dangane da hanyar aikace-aikacen:

• gudanarwar baka: sha yana faruwa a cikin gastrointestinal fili (gastrointestinal fili) cikin sauri da kuma gaba daya, yayin da ciwan Neurolipon tare da abinci, sha yake ragewa. Bioavailability ya kasance daga 30 zuwa 60%, kayan yana cikin metabolized kafin ya shiga cikin tsarin jini yayin wucewa ta bango na hanji da hanta (sakamako na farko-farko). Lokaci don isa wurin maida hankali (T_max) daidai yake da μg / ml kimanin mintuna 30 ne. Tsarin metabolism a cikin hanta yana faruwa ta hanyar hadawan abu da iskar shaka da kuma sarkewar hanji. Acrectic acid an keɓe shi a cikin fitsari ta hanyar kodan: a cikin hanyar metabolites - 80-90%, ba canzawa - ƙaramin adadin. T_1/2 (rabin rai) minti 25 ne,
• tsarin mulkin parenteral: bioavailability ne

30%, metabolism na faruwa a cikin hanta ta hanyar hadawan abu da iskar shaka da kuma sarkewar hanji. T_1/2 - Minti 20-50, jimlar tsagaitawa ce

694 ml / min, ƙarar rarraba shine lita 12,7. Bayan allura guda daya na maganin thioctic acid, cikin ta, tofincinta daga kodan a cikin awanni 3-6 na farko ya kai kashi 93 zuwa 9 cikin dari bisa dari na wani abun da ba'a canza shi ba ko kuma abubuwan da aka samo asali.

Umarnin don amfani da Neyrolipon: hanya da sashi

Ana ɗaukar neuroleipone mai siffar Capsule a baki a kan komai a ciki (rabin sa'a kafin cin abinci), ba tare da taunawa da shan ruwa da ruwa kaɗan ko wani ruwan tsaka tsaki.

Shawarar da aka ba da shawarar: 300-600 MG sau ɗaya a rana. Don lura da cututtukan cututtukan cututtukan ƙwayar cuta a farkon, gudanarwar parenteral na maganin thioctic acid yana da kyawawa.

Likita ya kayyade tsawon lokacin aikin jiyya daban-daban.

Sakamako don bayani don jiko

Maganin da aka shirya daga mai da hankali mai ƙarfi na Neyrolipon ana gudanar dashi ta hanyar jinkirin shigar cikin hanzari (≤ 50 mg thioctic acid a minti daya).

Sanarwa da aka ba da shawarar: MG 600 sau ɗaya a rana, a cikin mawuyacin hali, har zuwa 1200 mg an yarda.

Don shirya jiko bayani, ana amfani da maganin NaCl na 0.9% a cikin adadin 50-250 ml da 600 mg na thioctic acid.

Tsawon lokacin karatun shine makonni 2-4, bayan haka sun canza zuwa kulawa da maganin thioctic acid a cikin shirye-shiryen maganin (kashi 300 na 600 a kowace rana) na watanni 1-3.

Don haɓaka tasirin Neyrolipona, ana ba da shawarar gudanar da maimaita karatun tare da maimaita 2 sau a shekara.

Yawan abin sama da ya kamata

Bayyanar cututtukan overdose na thioctic acid lokacin da aka sha shi a baki na iya zama ciwon kai, tashin zuciya, amai, yawan jin jiki, rikicewar jiki a cikin ma'aunin acid-acid tare da lactic acidosis, ƙwanƙwasa jini, ƙarancin coagulation jini har zuwa mutuwa.

Don kula da yanayin, yakamata a daina shan magani, a wanke ciki, sannan a ɗauki gawayi a ciki kuma a ci gaba da kulawa.

Ba a san alamun bayyanar cututtukan overioctic acid tare da gudanarwar parenteral ba.

Idan kuna zargin yawan wucewa ko abin da ya haifar da mummunan tasirin, dole ne ku katse jiko, to, ba tare da cire allurar allura ba, a hankali gabatar da 0.9% isotonic NaCl mafita ta hanyar tsarin. Magungunan ba shi da takamaiman maganin rigakafi; magani yana bada shawarar.

Umarni na musamman

Hannun jiko na dauke da acid na thioctic yakamata a kiyaye shi daga haske ta hanyar rufe kwantena tare da garkuwoyin haske.

A cikin lura da marasa lafiya da ciwon sukari, ana buƙatar saka idanu akai-akai game da matakan glucose na jini, a wasu yanayi, idan ya cancanta, daidaitawar sashi na wakilai na hypoglycemic don hana haɓakar haɓakar cutar hanta.

Yayin yin jiyya tare da Neurolipone, yakamata mutum ya guji shan giya da ke ɗauke da giya, tunda ethanol yana hana aikin warkarwa.

Hulɗa da ƙwayoyi

• glucocorticosteroids: acid na thioctic yana haɓaka tasirin rigakafin tasirinsu,
• cisplatin: an lura da raguwa sakamakon warkewarta,
• kwayoyi dauke da karafa (baƙin ƙarfe, magnesium, shirye-shiryen alli): thioctic acid yana ɗaukar karafa, sabili da haka, ya kamata a guji gudanar da mulkin su na lokaci ɗaya, ya zama dole don kula da tazara tsakanin allurai na aƙalla 2 hours,
• insulin ko na baka hypoglycemic jamiái: thioctic acid na iya yin tasirin tasirin su,
• ethanol da metabolites: hana aikin thioctic acid.

Maganin jiko na siffofin Neyrolipon da wuya ake narke hadaddun mahaɗan tare da sugars, saboda haka ya dace da hanyoyin maganin Ringer, glucose, da fructose. Hakanan bai dace da hanyoyin maganin mahadi waɗanda ke amsa tare da rukunin SH-ko lalata gadoji da shirye-shiryen da ke tattare da Ethanol ba.

Ra'ayoyi game da neuroleepone

Reviews game da neuroleepone ne mai rikitarwa. Ga wasu marasa lafiya, maganin bai dace ba, ana kiran shi azaman magani wanda ba shi da ƙarfi wanda zai rage alamun cutar da kuma haifar da mummunan sakamako.

A cikin wasu masu sake dubawa, an lura da neurolypone a matsayin magani na zaɓin saboda rashin halayen halayen da kuma ingantaccen aiki.

Farashin Neyrolipon a cikin magunguna

Kimantawa farashin NeroLipone:

• mai da hankali don shirye-shiryen samar da mafita don jiko (ampoules 5 a cikin kwali na kwali): a cikin ampoules na 10 ml - 170 rubles, a cikin ampoules na 20 ml - 360 rubles,
• capsules (pcs 10. a cikin blisters, 3 blisters a cikin fakitin kwali) - 250 rubles.

Ilimi: Na farko Jami'ar Likita ta Jihar Moscow da aka sanya wa lakabi da I.M. Sechenov, ƙwararren "General Medicine".

Bayanai game da miyagun ƙwayoyi an samar da su, an bayar da su ne don dalilai na bayanai kuma baya maye gurbin umarnin hukuma. Kai magani yana da haɗari ga lafiya!

Yadda ake amfani: sashi da hanya na jiyya

Maganin maganin jiko ana gudanar dashi ne ta hanyar kai tsaye ga manya a kashi 600 na mg a rana. Ana gudanar da shi a hankali - ba fiye da 50 mg na thioctic acid (1.7 ml na bayani don jiko) a minti daya.

Ya kamata a gudanar da maganin ta hanyar jiko tare da 0.9% sodium chloride bayani 1 lokaci ɗaya kowace rana (600 mg na miyagun ƙwayoyi an haɗu da 50-250 ml na 0.9% sodium chloride bayani). A cikin lokuta masu tsauri, har zuwa 1200 MG ana iya gudanar da shi. Ya kamata a kare hanyoyin jiko daga haske ta rufe su da garkuwar wuta.

Aikin jiyya yana daga makonni biyu zuwa hudu. Bayan wannan, suna canzawa zuwa aikin kulawa tare da Neyrolipon don gudanar da maganin baka (capsules) a kashi 300-600 MG kowace rana don watanni 1-3. Ana ɗaukar capsules a baki ba tare da tauna ba, a wanke da ruwa kaɗan, minti 30 kafin cin abinci (a kan komai a ciki). Don inganta tasirin magani, ana ba da shawarar hanya sau biyu a shekara.

Tsawon likitan yana ƙaddara tsawon lokacin jiyya.

Ba a tabbatar da inganci da amincin magani a cikin yara ba.

Aikin magunguna

Sinadarin Thioctic acid, wanda yake bangare ne na Neuroleipon, yana aiki ne a cikin jiki kuma yana aiki azaman coenzyme a cikin narkeboxylation na oxidative decarboxylation na alpha keto acid, kuma yana taka muhimmiyar rawa a cikin karfin metabolism na kwayar. A cikin amide (lipoamide) tsari ne mai mahimmanci wanda ya samar da hadaddun enzyme masu rikitarwa wanda ke rikitar da acid din Krebs alpha-keto acid. Acid na Thioctic yana da maganin antioxidant da sakamako na antioxidant, yana kuma iya dawo da sauran magungunan antioxidants, kamar su ciwon suga. A cikin marasa lafiya da masu ciwon sukari, acid na thioctic yana rage juriya insulin kuma yana hana ci gaban neuropathy na yanki.

Yana taimakawa rage yawan glucose a cikin plasma da kuma yawan glycogen a cikin hanta. Acid na Thioctic acid yana shafar metabolism na cholesterol, yana ɗaukar nauyi a cikin tsari na lipid da carbohydrate metabolism, inganta aikin hanta (saboda maganin hepatoprotective, antioxidant, effects detoxification).

Haɗa kai

Yana haɓaka tasirin rigakafin cututtukan glucocorticosteroid.

Tare da gudanarwa na lokaci daya na thioctic acid da cisplatin, an lura da raguwa a cikin tasirin cisplatin.

Acid na Thioctic acid yana ɗaukar karafa, sabili da haka, bai kamata a tsara shi a lokaci ɗaya tare da kwayoyi masu ɗauke da karafa ba (misali baƙin ƙarfe, magnesium, alli) - tazara tsakanin allurai ya kamata ya zama aƙalla 2 hours.

Tare da yin amfani da lokaci guda na thioctic acid da insulin ko magungunan hypoglycemic na baki, ana iya inganta tasirin su.

Barasa da metabolitessa suna raunana sakamakon neuroleipone.