Gliclazide Canon: umarnin don amfani da allunan

Gliclazide Canon: umarnin don amfani da bita

Sunan Latin: Gliclazide Canon

Lambar ATX: A10BB09

Sinadaran mai aiki: Gliclazide (Gliclazide)

Mai gabatarwa: Kanonfarma samarwa, CJSC (Russia)

Sabuntawa da hoto: 07/05/2019

Farashin kuɗi a cikin kantin magani: daga 105 rubles.

Glyclazide Canon magani ne na baki wanda ya shafi ƙungiyar sulfonylurea rukuni na biyu.

Formaddamar da tsari da abun da ke ciki

Siffar sashi - allunan saki mai ɗorewa: kusan fararen fari ko fari, ƙaramar maɓalli na farfajiya, zagaye na biconvex, 60 MG kowane tare da layi mai rarrabawa (Gliclazide Canon 30 mg: 10 inji mai kwakwalwa. , 30 inji mai kwakwalwa a cikin fakiti, a cikin fakitin fakiti na 1 ko 2, Canon Glyclazide 60 MG: 10 inji a cikin fakitin bokaye, a cikin kwali na kwali na 3 ko fakitoci 6, cikin guda 15 a cikin fakitoci, kwali fakitin 2 ko 4, cikin Kowace fakitin ya ƙunshi umarni don amfanin Glyclazide Canon).

Abun ciki 1 kwamfutar hannu:

• abu mai aiki: gliclazide - 30 ko 60 mg,
• abubuwan taimako (30/60 mg): magnesium stearate - 1.8 / 3.6 mg, microcrystalline cellulose - 81.1 / 102.2 mg, hydrogenated oil oil - 3.6 / 7.2 mg, hypromellose - 50 / 100 MG, colloidal silicon dioxide - 3.5 / 7 mg, mannitol - 10/80 mg.

Pharmacodynamics

Glyclazide - abu mai aiki na Glyclazide Canon, mai samo asali ne mai mahimmanci wanda wakili ne na jini don gudanar da maganin baka. Ya bambanta da irin waɗannan kwayoyi a gaban ƙarar heterocyclic ringi na N-tare da haɗin endocyclic.

Gliclazide yana taimakawa rage yawan glucose na jini, wanda aka bayar ta hanyar ƙarfafa ɓoye insulin ta sel beta na tsibirin Langerhans. Tsawan lokacin sakamako na haɓaka abubuwan da ke cikin insprandial insulin da C-peptide yana ci gaba bayan shekaru 2 na maganin. Abun, ban da shafar metabolism na metabolism, yana da jijiyoyin jijiyoyin jini da kaddarorin antioxidant.

Lokacin amfani da Glyclazide Canon don lura da ciwon sukari na 2 na ciwon sukari, ana mayar da ganiyaye farkon insulin ɓoyewar a cikin martani ga yawan glucose da karuwa a kashi na biyu na ɓoye insulin. Sakamakon motsa jiki, wanda ya kasance sakamakon ƙaddamar da glucose ko ci abinci, ana samun karuwa sosai a cikin ɓoye insulin.

Ayyukan gliclazide an yi niyya don rage haɗarin ƙananan ƙwayoyin jini na jini, wanda ke faruwa sakamakon tasirin tasirin hanyoyin da za a iya danganta su da ci gaba da rikitarwa a cikin ciwon sukari mellitus. Waɗannan sun haɗa da: hanawa ga mamayar platelet da tarawa, raguwa a cikin abubuwan abubuwan kunna faranti (thromboxane B₂beta-thromboglobulin). Bugu da ƙari, Gliclazide Canon yana shafar maido da ayyukan fibrinolytic na endothelium na jijiyoyin jiki da haɓaka da ƙaruwa mai kunnawa plasminogen nama.

Idan aka kwatanta da daidaitaccen tsarin sarrafa glycemic (dangane da sakamakon binciken ADVANCE), saboda haɓaka glycemic sarrafawa dangane da tsawan-fitarwa glycazide far, ƙimar manufa ta HbAlc (glycosylated haemoglobin)

Alamu don amfani

Magungunan an yi niyya don maganin rashin lafiyar insulin-non-insulin-based diabetes mellitus (nau'in 2), idan gyaran abinci, nauyi da aikin jiki ba su kawo sakamako ba. Bugu da kari, miyagun ƙwayoyi ya dace don rigakafin rikice-rikice na ciwon sukari na 2 (micro- da macro-vascular pathologies), don lura da latent na cutar (latent, wanda babu alamun bayyanar cututtukan cututtukan ciwon sukari), tare da kiba na asalin tsarin mulki.

Abun ciki da nau'i na saki

An haɗa abubuwan da ke gaba a cikin magani:

• Mai aiki: gliclazide 30 ko 60 mg.
• Taimako: hydroxypropyl methylcellulose, silloon silikon dioxide, mannitol, E572 (magnesium stearate), man kayan lambu na hydrogenated, microcrystalline cellulose.

Gliclazide canon an yi shi ne don gudanar da maganin baka. Sigar ta hanyar: Allunan sakin allunan. Mai ƙera yana ba da bambance-bambancen magunguna: 30 da 60 MG. Allunan suna zagaye, convex daga bangarorin 2, fararen fata (launi mara launi iri daban-daban, ba a yarda ba), wari.

Hanyoyin warkarwa

Hanyar aiki tana da nasaba da tasirin abubuwan sulfonylurea waɗanda ke karɓar ragi a cikin cells-sel. Sakamakon abin da ya faru a matakin salula, an rufe tashoshin KATF + kuma membranes β-cell yana kwance. Sakamakon rushewar membranes sel, ana buɗe tashoshin Ca +, ion alli suna shiga cikin sel. An fitar da insulin kuma an sake shi zuwa cikin jini.

A lokaci guda, maganin sannu a hankali yana lalata sel na hanji, yana haifar da rashin lafiyan, rikicewar gastrointestinal, yana kara yiwuwar rashin lafiyar jiki, da dai sauransu. Yana aiki har sai ajiyar aikin insulin-roba mai narkewa ya yanke. Abin da ya sa tare da tsawanta yin amfani da miyagun ƙwayoyi, sakamakonsa na motsa jiki na farko kan rage ƙwayar insulin ya ragu. Bayan haka, bayan hutu cikin shigowa, ana mayar da halayen β-sel.

Gliclazide canon yana cikin sauri kuma yana ɗauka daga cikin narkewar abinci. Bayan cin abinci, matakin glucose ya tashi, don haka babban ɓangaren ɓoyewar ƙwayar insulin yana faruwa a wannan lokacin. Haɗewar yin amfani da miyagun ƙwayoyi da abinci na iya rage yawan sha. Babban mawuyacin halin rashin ƙarfi na iya rage jinkirin narkewa kuma wannan saboda gaskiyar cewa ilimin halayyar cuta yana haɗuwa da raguwa a cikin aikin motsa jiki na jijiyoyin jini.

Tasirin magani yana farawa tsakanin sa'o'i 2-3 bayan gudanarwa. Ana lura da mafi yawan abubuwan aiki a cikin jini bayan awa 7-10. Yawan aiki - kwana 1. Ya kasance a cikin fitsari, haka nan ta hanyar narkewa.

Hanyar aikace-aikace

Matsakaicin farashin maganin shine 60 MG - 150 rubles., 30 MG - 110 rubles.

Magungunan sun dace da manya kawai. Sashi a kowace rana - 30-120 mg. Yakamata yakamata a tsara ainihin likitan da ke halartar la'akari da matakin cutar, alamomin ta, sukari mai azumi da kuma awanni 2 bayan cin abinci, shekarun mai haƙuri da kuma matsayin mutum game da magani. A matsayinka na mai mulki, farkon farawa don lura da ciwon sukari ba ya wuce 80 MG, kuma don rigakafin ko azaman maganin kulawa - 30-60 mg.

Idan aka bayyana cewa sashi ba shi da tasiri sosai, to sannu a hankali yana kara haɓaka. Bugu da kari, kowane canji a tsarin kulawa ya kamata a fara aiwatar da shi tun farkon makonni biyu daga farkon jiyya. Idan aka rasa allurai 1 ko fiye, ba zai yuwu a kara sashi na gaba ba.

An bada shawara don shan kwayar rana sau 1 ta haɗiye kwamfutar hannu gaba ɗaya. Don hana haɗuwa da kayan magani da abinci, ya fi kyau amfani da miyagun ƙwayoyi rabin sa'a kafin cin abinci.

A lokacin daukar ciki da shayarwa

Tasirin magungunan a lokacin daukar ciki da tayin ba a fahimta sosai. Saboda haka, umarnin yin amfani da shi ya hana amfani da miyagun ƙwayoyi yayin lokacin haihuwar yaro da HB.

Contraindications da Kariya

Shigar da ke cikin contraindicated a gaban wadannan yanayi:

• insulin-da ke fama da ciwon sukari (nau'in 1),
• mai ciwon sukari ketoacidosis, coma,
• mai cutar hanta, cutar koda,
• tsawon lokacin haihuwa, GV,
• shekarun yara
• rashin hankali ga abubuwa a cikin abun da ke cikin miyagun ƙwayoyi.

Hypoglycemia yana tattare da raguwa a cikin taro, farin ciki, rashiwar jiki, da sauran alamu. Mai ciwon sukari ya kamata ya lura da yanayin yiwuwar wannan ilimin kuma ya mai da hankali lokacin da kake cikin ayyukan da ke buƙatar saurin psychomotor da sauri (alal misali, tuƙi mota).

Hulɗa da miyagun ƙwayoyi

Ana iya inganta tasirin magungunan ta hanyar wasu kwayoyi, wanda ke ƙara saurin haɓakar haɓakar haila. Canji na Glyclazide Canon yana haɗaka tare da Miconazole. Ba'a bada shawarar haɗarin ci tare da phenylbutazone, ethanol.

Haɗin magungunan tare da sauran wakilai na hypoglycemic (insulin, acarbose), beta-blockers, ACE inhibitors, shirye-shiryen alli, β-blockers yana buƙatar taka tsantsan, saboda haɓaka tasirin hypoglycemic.

Magunguna masu zuwa suna raunana sakamako na magani:

• Danazole - yana da tasirin ciwon sukari,
• Chlorpromazine - yana haɓaka sukari na jini, yana rage ɓoye insulin.

Side effects da yawan abin sama da ya kamata

Gliclazide canon yana haƙuri da haƙuri ta hanyar haƙuri. Magungunan yana da aiki fiye da maganin tsallewar ƙarni na farko. Wannan yana ba da damar yin amfani da ƙananan sigogi na kayan magani, wanda zai rage yiwuwar mummunan sakamako bayan amfani.

Amma tare da amfani da tsawan lokaci, sakamako masu illa na iya ci gaba. Ofayan mafi munin halayen haɗari shine haɓakar haɓakawar jini, musamman a cikin mutanen da suka girmi shekaru 50, tare da abubuwan da ke haifar da tsinkaye:

• Lokaci guda na gudanar da magunguna da yawa.
• Rage nauyi.
• Ba a cin abinci sosai.
• Shan giya.
• Take hakkin kodan, hanta, da dai sauransu.

Hakanan, a kan asalin cin abinci na yau da kullun, marasa lafiya sau da yawa sun kara yawan ci, wanda ke haifar da saiti na karin fam. Don hana karuwar nauyi, ana bada shawara don bin abinci mai ɗauke da jini.

Sauran mummunan tasirin shansu sun hada da:

• Rashin lafiyar Gastrointestinal: tashin zuciya, zawo, rashin jin ciki / rauni, amai.
• Allergy (rashes, itching na fata).
• CNS: rashin damuwa, rashin bacci, rashin jin daɗi, numfashi mara ƙarfi, rashin iya maida hankali, rikicewa, jinkirin, damuwa, damuwa, tsoro.
• Lu'u-lu'u, zuciya: palpitations, hauhawar jini, tashin zuciya.
• Hanta, biliary fili: cholestatic jaundice, hepatitis.
• Rashin gani na gani, pallor na fata.

Wadannan sakamako masu illa suna da ɗanɗano, a cikin 1-2% na marasa lafiya. Idan akwai abubuwan da aka ambata a sama, ya kamata a dakatar da gudanar da mulki.

An bada shawara don kauce wa mahimmin sashi na wani magani, kamar yadda Hadarin cutar hauhawar jini ya karu, kuma yawan kuzarin β-Kwayoyin na rage su. Akwai yiwuwar haɓaka mummunan yanayin barazanar rayuwa na cututtukan jini, har zuwa ƙwaƙwalwar hanji, amai, amai. A wannan halin, ana buƙatar asibiti mai gaggawa da ƙwararrun taimakon ma'aikatan lafiya.

Ana amfani da magani fiye da kima ta hanyar shigar glucose ko kuma sanya allura a ciki / cikin (50%, 50 ml), tare da kumburi kwakwalwa - cikin / a cikin Mannitol. Bugu da kari, ana buƙatar saka idanu akan matakan sukari a cikin kwanaki 2 masu zuwa.

Mai masana'anta: Lab. Masana'antu na Faransa, Faransa.

Matsakaicin kudin: 310 rub

Babban abu: gliclazide. Tsarin fara aiki na Tablet.

Abvantbuwan amfãni: da wuya ya haifar da sakamako masu illa (a cikin kusan 1% na masu ciwon sukari), haɓaka haɓaka, sannu a hankali yana rage glucose, rage haɓakar jini, umarnin dacewa don amfani.

Misalai: babban farashi, sannu a hankali yana lalata cells-sel.

Mai kera: Ranbaxi Laboratories Ltd., India.

Matsakaicin kudin: 200 rub Babban abu: gliclazide. Tsarin fara aiki na Tablet.

Abvantbuwan amfãni: yadda yakamata ya zama alamu na kwantar da hankalin mutum a cikin jini, yaduwar kwayar halitta akan β-sel sabanin abubuwan farko na jini, yana rage yiwuwar fitar jini.

Misalai: da wuya a samu a cikin kantin magunguna; yin amfani da kullun yana haifar da ci gaba da ciwon sukari wanda ke dogaro da ciwon sukari mellitus

Tsarin saki, abun da aka shirya da marufi

Jagororin da ke gudana don yin amfani da Canon Glyclazide suna nuna kasancewarta ga rukuni na magungunan da ke rage sukarin jini, jagorancin baka da gaskiyar cewa yana kunshe ne a cikin nau'ikan ƙayyadaddun maganin sulfonylurea na ƙarni na biyu. Yana da siffar kwamfutar hannu zagaye, convex a garesu, fari. Dangane da sake duba Glyclazide Canon, ana nuna su ta hanyar iska mai sauƙi. Wani fasali na allunan shine ingantaccen saki, wanda ke nufin cewa suna da ragi da yawa na allurai, amma suna da tasiri mai daɗewa. Babban maɓallin shine gliclazide a cikin girman 30 MG da 60 MG. An gabatar da jerin ƙarin abubuwan ta hanyar mannitol, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.Gliclazide Canon farashin a cikin Moscow da sauran yankuna suna da araha ga underan ƙasa da ke fuskantar aikin warkarwa ta amfani da wannan magani.

Aikin magunguna

Babban aikin Canon Gliclazide shine haifar da samar da ƙwayoyin insulin beta a cikin ƙwayar ƙwayar cuta. Har ila yau, maganin yana taimakawa wajen haɓakar insulin a cikin yadudduka na gefe. Wato, yana da alhakin haɓakar kuzarin enzymes a cikin sel. Yana gajarta lokacin tazara tsakanin abinci da farkon sakin insulin. Yana shafar sake kasancewar farkon ƙaddamar da ƙaddamarwar insulin da raguwa a cikin ƙwayar postprandial na hauhawar hyperlycemia. Glyclazide Canon yana taimakawa rage yawan haɗin platelet da mannewa, yana rage jinkirin samuwar thrombi parietal, kuma yana inganta aikin jijiyoyin fibrinolytic. Mai alhakin daidaituwa na lalata jijiyoyin bugun jini. Hakanan yana da ƙirar anti-atherogenic, waɗanda ke nunawa a cikin raguwar cholesterol jini, haɓaka tarin jari na HDL-C, da raguwa a cikin adadin tsoffin tsarukan rashin kyauta. Yana hana atherosclerosis da microthrombosis, kasancewar su. Yana rage karfin jijiyoyin jiki zuwa adrenaline kuma yana da amfani mai amfani wajen inganta microcirculation. Amfani da Canon Glyclazide na tsawon lokaci yana rage furotin a cikin cututtukan dake fama da cutar sankara. Kasancewa da miyagun ƙwayoyi daga jijiyar gastrointestinal na faruwa da sauri fiye da na Canon Gliclazide analogues. Nishadi yakan faru ne ta hanyar kodan ta amfani da metabolites, kuma kusan 1% ta fitsari.

Gliclazide Canon an kirkiro shi ne ga marasa lafiya waɗanda suka sami kasancewar nau'in mellitus na nau'in 2, don daidaita nauyi, shima don ƙara ƙarfin jimami da ƙarfin motsa jiki, kuma a waɗannan lokutan waɗanda ƙarancin kalori ba ya kawo sakamako mai amfani. Ya dace azaman prophylaxis game da ɓarnawar cututtukan cututtukan ƙwayar cuta: don hana haɗarin fashewar cututtukan microvascular, da haɓakar macrovascular - bugun jini da bugun zuciya, ta hanyar haɓaka aikin glycemic.

Side effects

Sakamakon sakamako daga amfani da miyagun ƙwayoyi sune: - cutar cututtukan zuciya wanda ke haifar da rashin isasshen abinci da ƙarancin abinci, - ciwon kai, - gajiya, - haɓaka ɗumi, - saurin bugun zuciya, - rauni da nutsuwa, - hawan jini, - fitowar damuwa mai yawa, - matsaloli tare da bacci, - yanayin arrhythmia, - juyayi da fushi, - bayyanar matsaloli tare da kayan magana da ɓarkewar jijiyar gani, - jinkirin sassauƙa, - tashin hankali, - yanayin tashin hankali, - rawar jiki a ƙarshen styah - fadowa cikin wani coma, - rufe da mãgãgi, - girgizawarta, - da halin da ake ciki na gazawan - da rashin kamewa - fitowan bradycardia. Kwayoyin narkewa suna amsawa tare da bayyanar zawo, amai, ciwon ciki, matsaloli tare da matsi, wani lokacin akwai cutar hanta.Tare da cutar hepatitis da cholestatic jaundice, akwai buƙatar gaggawa don soke magani, ƙara yawan haɓakar transpaseases na hepatic, alkaline phosphatase. Gabobin da ke da alhakin hematopoiesis suna ba da sigina waɗanda ke nuna bacin ran kashi. Allergic mai saukin kamuwa yana bayyana ta hanyar faruwar itching da kurji a jiki, erythema da urticaria. Abubuwan da ke cikin Sulfonylurea sun amsa ta hanyar vasculitis, erythropenia, hemolytic anemia, pancytopenia, agranulocytosis, da aikin lalata hanta, wanda zai iya zama barazanar rayuwa.

Yawan abin sama da ya kamata

A cikin halin da ake ciki na wuce adadin halatta na Canon Glyclazide, akwai yiwuwar cutar hawan jini, yanayin fitsari da haɗarin fadawa cikin ƙwayar cutar hauhawar jini. Don lura da marasa lafiya waɗanda ke da hankali, wajibi ne a ɗauki sukari a ciki. Hakanan akwai haɗarin kamuwa da cuta, rikicewa daga ƙwaƙwalwar ƙwaƙwalwa, a sakamakon yanayin rashin lafiyar hypoglycemic. Wannan halin yana buƙatar amsawa ta gaggawa ta likitoci da kuma asibiti na gaggawa. Karkashin zato ko sanannen ƙwayar warin jini, ana buƙatar allurar 40% na glucose a cikin 50 ml a cikin gaggawa, to, don kula da isasshen matakin sukari, cakuda 5% dextrose ana shigar da shi cikin nutsuwa. A cikin 'yan awanni masu zuwa bayan wanda abin ya rutsa da kansa ya zo kansa, don hana sake dawowa da cutar cututtukan jini, yana buƙatar ciyar da shi abincin da ke da wadataccen ƙwayoyin carbohydrates a cikin sauƙin narkewa. Don ƙarin awoyi 48, riƙe mai haƙuri a ƙarƙashin kulawa da sanya idanu akan matakin glucose na mai haƙuri. Duk sauran abubuwan da likitoci suka duba ya dogara da yanayin lafiyarsa. A cikin irin wannan yanayi, dangane da ɗaure gliclazide zuwa ƙwayoyin plasma, tsarkakewar dialysis ba zai yi tasiri ba.

Hulɗa da ƙwayoyi

Haɗin Canon Glyclazide tare da maganin anticoagulants wani lamari ne mai mahimmanci, saboda miyagun ƙwayoyi suna inganta tasirin su, wanda ke buƙatar daidaita sashi. Miconazole ya tura don kara dagula yanayin rashin lafiyar. Kafin da bayan phenylbutazone, akwai buƙatar yin bita da bincika matakin glucose a cikin jini da yin gyare-gyare ga adadin glyclazide da aka ɗauka, saboda gaskiyar cewa yana ba da gudummawa ga kunnawar tasirin hypoglycemic. Magunguna, tare da kasancewar ethyl barasa a cikin samarwa, na iya haɓaka hypoglycemia, da haɓaka ƙwaƙwalwar ƙwayar cuta. Amfani da layi daya na Canon Glyclazide tare da magungunan ƙungiyar ta (insulin, acarbose), beta-blockers, fluconazole, monoamine oxidase inhibitors, H2-histamine receversor blockers, abubuwanda ba su da steroidal anti-mai kumburi abubuwa, sulfonamides sun lalata yanayin hypoglycemic da hypoglycemic illa. Diabetogenic sakamako yana da danazol. Rage samuwar insulin da kuma tarawarsa a cikin jini yana haifar da babban adadin chlorpromazine. Gudanar da terbutaline ta hanyar jijiyoyin, salbutamol da ritodrine suna ƙaruwa kuma suna tara glucose. Akwai buƙatar saka idanu akan matakin sa kuma ayi canje canje a hanyar da aka zaɓa don maganin insulin far.

Umarni na musamman

Tsarin jiyya tare da Glyclazide Canon yana haɗuwa tare da kiyayewar rage yawan kalori, abinci mai kyau na yau da kullun tare da tilasta karin kumallo da yawan adadin carbohydrates masu shigowa. Sakamakon gudanarwar abubuwan da ke haifar da abubuwan da suka samo asali na maganin sulfonylurea, hypoglycemia yana da ƙarfin haɓaka, wani lokacin ba wucewa ba tare da allurar glucose da sanya asibiti a asibiti ba. Haɗuwa da giya, ɗaukar adadin wakilai na hypoglycemic a layi daya, yawan motsa jiki na wuce haddi na iya haifar da hypoglycemia. Rashin hankali, tunanin sake duba abinci yana buƙatar daidaita sashi na magani. Raunin raunin jiki, kasancewar ƙonewa mai zafi, cututtukan da ke haifar da cututtuka daban-daban da kuma buƙatar yin aikin tiyata, a cikin abin da wa'adin insulin zai yiwu, sune abubuwan da ke buƙatar sokewa na shan Glyclazide Canon. Tsarin magani tare da miyagun ƙwayoyi na iya shafar maida hankali da amsawa da sauri, don haka a ɗan lokaci kuna buƙatar barin kasancewa a baya da dabaran da hanyoyin aiki waɗanda ke buƙatar mafi yawan taro. Tsarin magani ya kamata ya kasance tare da ƙayyadaddun matakan matakin glucose da gemocosylated haemoglobin a cikin jini, da kuma maida hankali a cikin fitsari.

Glyclazide Canon

Allunan kwantar da hankali Allunan fari ko kusan fararen fata, zagaye, biconvex, tare da haɗari, an yarda da ƙaramar marbling.

Mahalarta: hypromellose (hydroxypropyl methylcellulose) - 100 MG, colloidal silicon dioxide - 7 mg, mannitol - 80 mg, magnesium stearate - 3.6 mg, hydrogenated oil oil - 7.2 mg, microcrystalline cellulose - 102.2 mg.

10 inji mai kwakwalwa. - fakiti mai bakin ciki (3) - fakitoci na kwali. - fakitin bakin ciki (6) - fakitoci na kwali. - fakitin bakin (2) - fakitoci na kwali.

Guda 15. - fakiti mai bakin ciki (4) - fakitoci na kwali.

Pharmacokinetics

Bayan gudanar da baki, yana sha da sauri daga narkewa. Cmax a cikin jini an kai shi kimanin awa 4 bayan ɗaukar kashi ɗaya na 80 MG.

Shafaffen furotin na Plasma shine kashi 94,2%. Vd - kimanin 25 l (0.35 l / kg nauyin jiki).

An metabolized a cikin hanta tare da samuwar 8 metabolites. Babban metabolite ba shi da tasirin hypoglycemic, amma yana da tasiri akan microcirculation.

T1 / 2 - sa'o'i 12. Ana raba shi ta hanyar kodan ta hanyar metabolites, ƙasa da 1% an keɓe shi a cikin fitsari ba canzawa.

Nau'in nau'in ciwon sukari na 2 da ƙarancin ingantaccen aikin maganin abinci, aikin jiki da asarar nauyi.

Yin rigakafin rikitarwa na nau'in ciwon sukari na 2 na jini: rage hadarin microvascular (nephropathy, retinopathy) da rikitarwa na macrovascular (infarction na myocardial, rauni).

Glyclazide MV 30 MG da MV 60 MG: umarnin da sake dubawa ga masu ciwon sukari

Gliclazide MV shine ɗayan magungunan cututtukan sukari na nau'in 2 da aka fi amfani dasu. Ya kasance na ƙarni na biyu na shirye-shiryen sulfonylurea kuma ana iya amfani dashi duka a cikin monotherapy kuma tare da sauran allunan rage sukari da insulin.

Bugu da ƙari ga tasirin sukari na jini, gliclazide yana da tasiri mai kyau a cikin abubuwan da ke tattare da jini, yana rage damuwa oxidative, inganta microcirculation. Magungunan ba tare da lalacewarsa ba: yana ba da gudummawa ga samun nauyi, tare da tsawanta amfani, allunan sun rasa tasiri. Koda kadan yawan abin shafawa na gliclazide yana da kashi tare da hypoglycemia, haɗarin yana da girma musamman a cikin tsufa.

Babban bayani

Shafin rajista na Gliclazide MV ne kamfanin kamfanin Russia na Atoll LLC ya bayar. Magungunan a karkashin kwangilar ne kamfanin samarda magunguna na Samara Ozone ya samar. Yana samarwa da kuma tattara Allunan, kuma yana sarrafa ingancin su.

Gliclazide MV ba za a iya kiranta gabaɗaya magungunan cikin gida ba, tunda ana siyar da wani magani a kansa (guda glyclazide) a China. Duk da wannan, babu wani mummunan abu da za a iya faɗi game da ingancin ƙwayoyi.

A cewar masu ciwon sukari, ba mafi muni ba tare da Faransawa masu ciwon sukari tare da wannan abun da ke ciki.

Rashin raguwa na MV da sunan miyagun ƙwayoyi yana nuna cewa abu mai aiki a ciki an gyara shi, ko tsawaita shi, saki.

Glyclazide ya bar kwamfutar hannu a lokacin da ya dace kuma a inda ya dace, wanda ke tabbatar da cewa bai shiga cikin jini kai tsaye ba, amma a cikin kananan bangarori. Saboda wannan, ana rage haɗarin sakamako marasa amfani, ana iya ɗaukar miyagun ƙwayoyi ba sau da yawa.

Idan aka keta tsarin kwamfutar hannu, aikinta ya ɓace, saboda haka, umarnin don amfani baya bada shawara a datse shi.

An haɗa Glyclazide a cikin jerin mahimman magunguna, don haka endocrinologists suna da damar da za a iya tsara shi ga masu ciwon sukari kyauta. Mafi sau da yawa, bisa ga takardar sayan magani, MV Gliclazide ne na gida wanda yake analog na ainihin masu ciwon sukari.

Yaya maganin yake aiki?

Dukkanin gliclazide da aka toya a cikin narkewa shine yake shiga cikin jini to akwai ɗaukar nauyin jikinta. A yadda aka saba, glucose ya shiga cikin sel na beta kuma yana ƙarfafa masu karɓa na musamman waɗanda ke haifar da sakin insulin. Glyclazide yana aiki da wannan ka'ida, yana haifar da tsohuwar hanyar jigilar kwayoyin.

Sakamakon aikin insulin bai iyakance ga tasirin MV Glyclazide ba. Magungunan sun iya:

1. Rage juriya insulin. Mafi kyawun sakamako (ƙwarewar insulin da kashi 35%) ana lura dashi a cikin ƙwayar tsoka.
2. Rage hadarin glucose ta hanta, ta yadda zai dace da tsarin azumi.
3. Ta hana jini kwance.
4. Imarfafa aikin sinadarin nitric oxide, wanda ya shiga cikin daidaita matsi, rage kumburi, da inganta haɓaka jini zuwa gaɓar sel.
5. Yi aiki azaman antioxidant.

Fitar saki da sashi

A cikin kwamfutar hannu Gliclazide MV shine 30 ko 60 MG na kayan aiki.

Sinadaran kayan taimako sune: cellulose, wanda ake amfani dashi azaman bulking, silica da magnesium stearate a matsayin emulsifiers.

Allunan fararen launi ko launi mai tsami, an sanya su cikin blisters na 10-30. A cikin fakitin 2-3 na blisters (30 ko allunan 30 ko 60) da umarnin. Za'a iya raba Glyclazide MV 60 MG cikin rabi, don wannan akwai haɗari akan allunan.

Ya kamata a bugu da magani a lokacin karin kumallo. Gliclazide yana aiki ba tare da la'akari da kasancewar sukari a cikin jini ba. Don haka cewa hypoglycemia ba ya faruwa, babu abincin da ya kamata ya tsallake, kowannensu yakamata ya yi daidai adadin carbohydrates. A bu mai kyau ku ci har sau 6 a rana.

Dokokin zaɓi na sashi:

Cikakkun umarnin don amfani

Dangane da shawarwarin asibiti na Ma'aikatar Lafiya ta Tarayyar Rasha, ya kamata a rubanya gliclazide don tayar da insulin insulin. A ma'ana, yakamata a tabbatar da rashin lafiyar kwayar halitta ta hanyar binciken mai haƙuri. Dangane da sake dubawa, wannan ba koyaushe bane yake faruwa. Likitocin kwantar da hankali da endocrinologists suna rubanya maganin "ta ido".

Sakamakon haka, fiye da adadin insulin da ake buƙata yana ɓoye, mai haƙuri koyaushe yana son cin abinci, nauyinsa yana ƙaruwa a hankali, kuma biyan diyya don ciwon sukari bai isa ba. Bugu da ƙari, ƙwayoyin beta tare da wannan yanayin aiki suna lalata da sauri, wanda ke nufin cewa cutar ta tafi mataki na gaba.

Yadda za a guji irin waɗannan sakamako:

1. Fara tsananin bin abincin don masu ciwon sukari (tebur mai lamba 9, adadin da aka yarda da shi na yawan carbohydrates yana ƙaddara ta likita ko mai haƙuri da kansa bisa ga glycemia).
2. Introduaddamar da motsi mai aiki a cikin ayyukan yau da kullun.
3. Rasa nauyi zuwa al'ada. Yawan mai mai wuce gona da iri yana cutar da ciwon suga.
4. Sha glucophage ko misalinsa. Mafi kyawun kashi shine 2000 MG.

Kuma kawai idan waɗannan matakan basu isa sukari na al'ada ba, zaku iya tunani game da gliclazide. Kafin fara magani, yana da kyau a ɗauki gwaje-gwaje don C-peptide ko insulin don tabbatar da cewa ƙwayar hormone ba ta da kyau.

Lokacin da glycated haemoglobin ya fi 8.5%, MV Gliclazide za'a iya ba shi tare da abinci da metformin na ɗan lokaci, har sai an biya dila. Bayan wannan, batun cire magunguna an yanke hukunci daban-daban.

Yadda ake ɗauka yayin daukar ciki

Umarnin don amfani da shi ya hana magani tare da Gliclazide yayin daukar ciki da kuma lactation. Dangane da rarrabuwar FDA, maganin yana cikin aji na C. Wannan yana nufin yana iya yin illa ga ci gaban tayin, amma baya haifar da alamun haihuwa. Gliclazide mafi aminci shine maye gurbin tare da ilimin insulin kafin daukar ciki, a cikin matsanancin yanayi - a farkon sosai.

Ba a gwada yiwuwar shayarwa tare da gliclazide ba. Akwai tabbaci cewa shirye-shiryen sulfonylurea na iya wucewa cikin madara kuma suna haifar da ƙin jini a cikin jarirai, don haka an haramta yin amfani da su a wannan lokacin.

Ga wanda Glyclazide MV ya saba wa doka

Me za a iya maye gurbinsa

Gliclazide na Rasha ba shi da tsada, amma maimakon magani mai inganci, farashin kayan kwalliyar Gliclazide MV (30 MG, guda 60) ya kai 150 rubles. Sauya shi da analogues ne kawai idan ba a sayar da allunan da aka saba ba.

Magunguna na asali shine Diabeton MV, duk wasu magunguna masu daidaitaccen tsari, gami da Gliclazide MV sune kwayoyin, ko kwafe. Farashin Diabeton ya kusan sau 2-3 sau da yawa na kayanta.

Glyclazide MV analogues da maye gurbin rajista a cikin Federationungiyar Tarayyar Rasha (kawai an shirya shirye-shiryen sakin fasalin da aka nuna):

• Glyclazide-SZ ne ya samar ta Severnaya Zvezda CJSC,
• Golda MV, Farmasintez-Tyumen,
• Gliclazide Canon daga Canonpharm Production,
• Glyclazide MV, Mai Taimakawa-Tomskkhimfarm,
• Diabetalong, masana'antar MS-Vita,
• Gliklada, Krka,
• Glidiab MV daga Akrikhin,
• Diabefarm MV Pharmacor Production.

Farashin analogues shine 120-150 rubles a kowane kunshin. Gliklada da aka yi a Slovenia shine magani mafi tsada daga wannan jerin, farashin shirya kusan 250 rubles.

Nazarin masu ciwon sukari

Sergei, 51 years old ya bita. Ciwon sukari mellitus na kusan shekaru 10. Kwanan nan, sukari ya isa 9 da safe, don haka an sanya Glyclazide MV 60 MG 60. Kuna buƙatar sha shi a hade tare da wani magani, Metformin Canon.

Dukansu magunguna da abinci suna ba da sakamako mai kyau, haɗarin jini ya koma al'ada a cikin mako guda, bayan wata ɗaya ya daina daina ƙafafun ƙafa. Gaskiya ne, bayan kowane cin zarafin abincin, sukari ya tashi da sauri, sannan sannu a hankali yana raguwa a ranar. Babu sakamako masu illa, an yarda da komai da kyau.

Ana ba da magunguna kyauta a asibitin, amma koda kun saya da kanku, ba shi da tsada. Farashin Gliclazide shine 144, Metformin shine 150 rubles. Elizabeth, mai shekara 40, ta yi bita. Glyclazide MV ya fara shan ruwa wata daya da suka wuce, masaniyar endocrinologist an wajabta ban da Siofor, lokacin da bincike ya nuna kusan kashi 8% na gemoclobin glycated.

Ba zan iya faɗi mummunan abu ba game da sakamakon, ya rage sukari da sauri.Amma tasirin sakamako gaba ɗaya ya hana ni damar yin aiki. Aikina yana da alaƙa da tafiya koyaushe; Ba koyaushe nake sarrafa cin abinci akan lokaci ba. Siofor ya yafe mini kurakurai a cikin abinci mai gina jiki, amma tare da Gliclazide wannan lambar ba ta shiga ba, an ɗan jinkirta - hypoglycemia ya kasance a can.

Kuma kayan ciye-ciye nawa ba su isa ba. Ya isa ga ma'anar cewa a ƙafafun dole ku tauna ɗan itacen zaki.

Ivan, mai shekara 44 ya bita. Kwanan nan, maimakon Diabeton, sun fara ba da Gliclazide MV. Da farko ina so in sayi tsohuwar ƙwayar cuta, amma daga baya na karanta sake dubawa kuma na yanke shawarar gwada sabon. Ban ji bambanci ba, amma 600 rubles. sami ceto. Duk magunguna biyun suna rage sukari sosai da haɓaka rayuwata. Hypoglycemia ne sosai rare kuma koyaushe na laifi. A dare, sukari baya faɗuwa, musamman ana duba shi.

Saki siffofin da abun da ke ciki

Ana samun magungunan a cikin nau'ikan kwayoyin magani, wanda ake nuna shi da ingantaccen saki. Mai ƙera yana ba da allurai 2: 30 MG da 60 MG. Allunan suna da siffar biconvex zagaye da farin launi. Abun magungunan ya hada da:

• abu mai aiki (gliclazide),
• ƙarin sinadaran: colloidal silicon dioxide, microcrystals cellulose, magnesium stearate (E572), hydroxypropyl methyl cellulose, mannitol, man kayan lambu na hydrogenated.

Ana samun magungunan a cikin nau'ikan kwayoyin magani, wanda ake nuna shi da ingantaccen saki.

Tare da kulawa

Za'a iya amfani da magani don matsakaici zuwa ƙarancin rauni na koda da aikin hanta. An wajabta maganin tare da taka tsantsan a cikin abubuwan da ke biyo baya da yanayin:

• rashin daidaituwa ko rashin abinci mai gina jiki
• cututtukan endocrine
• mummunan cututtuka na CVS,
• rashin ƙarfi na glucose-6-phosphate,
• barasa
• tsofaffi marasa lafiya (shekaru 65 da haihuwa).

Jiyya da rigakafin cutar sankara

Kashi na farko na maganin a cikin maganin cututtukan da ba su da insulin-insulin da kuma amfani da sulfonylurea bai kamata ya wuce 75-80 g ba .. Don dalilai na hanawa, ana amfani da maganin a 30-60 mg / day.

A wannan yanayin, likita ya kamata a hankali lura da matakin sukari a cikin haƙuri 2 sa'o'i bayan cin abinci kuma a kan komai a ciki.

Idan an gano cewa maganin bai da inganci, to ya haɓaka fiye da kwanaki.

A miyagun ƙwayoyi yana da kyau mai saukin kamuwa ga jiki. Koyaya, tare da tsawaita amfani da miyagun ƙwayoyi, marasa lafiya na iya fuskantar halayen marasa illa.

Don dalilai na hanawa, ana amfani da maganin a 30-60 mg / day.

A wani ɓangaren hanta da ƙwayar biliary

• hepatitis
• Jazzice cholestatic.

• asarar tsinkaye tsinkaye,
• pressureara yawan matsa lamba na ciki.

Ana amfani da miyagun ƙwayoyi a hade tare da abinci mai ƙarancin carb.

Lokacin ɗaukar shi, mai haƙuri dole ne ya samar da iko na tattarawar glucose a cikin jini.

Lokacin ɗaukar ƙwayar, dole ne mai haƙuri ya ba da ikon kula da yawan haɗuwar glucose a cikin jini.

A cikin ciwon sukari na mellitus a cikin ɓarna ko bayan tiyata, yiwuwar yin amfani da shirye-shiryen insulin.

Adanar Glyclazide Canon ga Yara

An haramta amfani da miyagun ƙwayoyi don amfani da yara ƙanana.

An yarda wa tsofaffi marasa lafiya damar amfani da magani a cikin mafi ƙarancin magani kuma suna ƙarƙashin kulawa ta fuskar lafiya.

Haramun ne a yi amfani da wadannan kwayoyin magungunan tare da tasirin hypoglycemic tare da bayyanar cututtukan koda. An zabi kashi akayi daban-daban dangane da yanayin marasa lafiya da ke fama da rauni aiki.

Ba da shawarar haɗuwa ba

Ba a so a yi amfani da magungunan ethanol da ke kunshe da kwayoyi na tushen chlorpromazine a lokaci guda tare da maganin da ake tambaya.

Phenylbutazone, Danazole da barasa suna haɓaka tasirin cutar ƙwayar cuta. A wannan yanayin, yana da kyau a zaɓi wani magani na ƙonewa daban.

Haɗuwa yana buƙatar taka tsantsan

Haɗin maganin tare da Acarbose, beta-blockers, biguanides, Insulin, Enalapril, Captopril da wasu magungunan anti-inflammatory marasa steroidal magunguna da magungunan da ke dauke da chlorpromazine na buƙatar kulawa ta musamman, saboda a cikin wannan yanayin akwai haɗarin hypoglycemia.

Masu ciwon sukari

Arkady Smirnov, mai shekara 46, Voronezh.

Idan ba don wadannan kwayoyin ba, da hannaye na sun faɗi tuntuni. Na daɗe da rashin lafiya tare da nau'in ciwon sukari na 2 na dogon lokaci. Wannan magani yana daidaita sukari na jini da kyau. Daga cikin sakamako masu illa, na ci karo da tashin zuciya kawai, amma ta wuce kanta bayan wasu 'yan kwanaki.

Inga Klimova, 42 years old, Lipetsk.

Mahaifiyata tana da ciwon sukari-wanda ba shi da insulin. Likita ya rubuta mata magungunan. Yanzu ta zama mai farin ciki da rayuwa mai kyau.